CN104780902A - Composition for external use - Google Patents

Abstract

A composition for external use which comprises (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea and which is practically sufficiently inhibited from suffering a decrease in viscosity with the lapse of time and a decrease in use feeling or humectant performance which accompanies the viscosity decrease.

Description

Topical composition

Technical field

The present invention relates to the compositions containing acid mucopolysaccharides, it is that the characteristic of acid mucopolysaccharides keeps stable topical composition.

Background technology

Because being exposed to, ultraviolet, temperature or humidity change such extrinsic factor to skin, the age increases the various factors such as such intrinsic factor and cause water tariff collection function or skin barrier function to reduce, and cause the various worries such as drying, pruritus, macule, ulcer, miliaria thus.In order to improve these symptoms, primary is to eliminate reason, but by coating containing the pharmaceuticals of moisturizing ingredient, cosmetics and make water tariff collection function or skin barrier function normalization be effective.

As the compound with moisture-keeping function, be used as the hyaluronic acid of mucopolysaccharide, chondroitin sulfate, heparin, dermatan sulfate, Heparan sulfate and keratan sulfate etc.When hyaluronic acid is as representative examples described; hyaluronic acid is the mucopolysaccharide comprising glucuronic acid and N-acetyl glucosamine; its be in vivo to be filled in iuntercellular, the mode of interfibrous mating substance to be present in a large number in corium and in epidermis, also to confirm the material of existence, has high water-retaining property and viscoelasticity.Based on such character, in the medical field as corneal epithelium treating dysfunction with putting drops in one's eyes, the composition of morphotropism gonarthrosis treatment injection drug etc. uses, and uses as wetting agent in cosmetic field.

Like this, mucopolysaccharide is the polysaccharide thickening agent of the wetting agent being typically used as external preparation.Knownly in external preparation, in most cases add surfactant from viewpoints such as preparation aspect or use senses, but mucopolysaccharide because of with surfactant and with and viscosity is reduced.This viscosity be reduced in compositions be exposed to light, heat when remarkable especially.Because the viscosity of mucopolysaccharide reduces, exist and reduce such problem as the moisture feeling of the use sense of the compositions containing mucopolysaccharide, sense of compacting.In addition, also there is the impaired such problem of moisture-keeping functions of the compositions containing mucopolysaccharide.

On the other hand, propose multiple suppression mucopolysaccharide through time viscosity reduce method.

Such as, patent documentation 1 teaches: the skin preparations for extenal use containing high molecular weight hyaluronic acid, low-molecular-weight hyaluronic acid, polyhydric alcohol and edetate through time viscosity reduce be inhibited, moisture retaining quality is excellent.

In addition, patent documentation 2 teaches: by coordinating specific vegetable oil containing hyaluronic acid or being applied in the compositions of mucosa of its salt, even if when containing surfactant, and the viscosity reduction of compositions is also inhibited.

In addition, patent documentation 3 teaches: by coordinating fatsoluble vitamin containing hyalomitome acids and being applied in the fluid composition of mucosa of surfactant, and the viscosity reduction of compositions is inhibited.

But, for the compositions recorded in these documents, mucopolysaccharide through time viscosity reduce and accompany therewith use sense, performance of keeping humidity deterioration suppression in practical and insufficient.In addition, the liposoluble substance that the compositions of patent documentation 2 and 3 has coordinated vegetable oil, fatsoluble vitamin such, therefore, be difficult to the transparency maintaining compositions, the topical composition be difficult to as cosmetics etc. uses.

Prior art document

Patent documentation

Patent documentation 1: No. 1-190614, Japanese Unexamined Patent Publication

Patent documentation 2: No. 2006-117656, Japanese Unexamined Patent Publication

Patent documentation 3: No. 2004-359629, Japanese Unexamined Patent Publication

Summary of the invention

Invent problem to be solved

Problem of the present invention is to provide the topical composition containing acid mucopolysaccharides, its through time viscosity reduce and accompany therewith use sense, performance of keeping humidity through time reduce be fully suppressed in practical.

For the method for dealing with problems

The present inventor is studied repeatedly in order to solve the problem, find when the cooperation of acid mucopolysaccharide apoplexy due to endogenous wind has the compound of polyoxy alkylidene, the viscosity of compositions easily through time reduce, but by coordinating hydroxyalkylurea further, compositions through time viscosity reduce and significantly suppressed.

The present invention completes based on above-mentioned opinion, and it provides following topical composition.

Item 1. 1 kinds of topical compositions, it contains (a) acid mucopolysaccharides, (b) has the compound of polyoxy alkylidene and (c) hydroxyalkylurea.

The topical composition of item 2. as described in item 1, wherein, hydroxyalkylurea is N-(2-ethoxy) urea.

3. topical compositions as described in item 1 or 2, wherein, acid mucopolysaccharides is selected from the group be made up of hyaluronic acid and chondroitin sulfate and their salt.

The topical composition of item 4. according to any one of item 1 ~ 3, wherein, the compound with polyoxy alkylidene is polyoxy butylidene polyoxyethylene polyoxypropylene glycerol.

The topical composition of item 5. according to any one of item 1 ~ 4, wherein, relative to compound 1 weight portion with polyoxy alkylidene, the hydroxyalkylurea containing 0.0001 ~ 2000 weight portion.

The topical composition of item 6. according to any one of item 1 ~ 5, wherein, relative to acid mucopolysaccharides 1 weight portion, the hydroxyalkylurea containing 0.01 ~ 10000 weight portion.

The topical composition of item 7. according to any one of item 1 ~ 6, wherein, relative to the total amount of compositions, containing the acid mucopolysaccharides of 0.000001 ~ 1 % by weight.

The topical composition of item 8. according to any one of item 1 ~ 7, wherein, relative to the total amount of compositions, containing the hydroxyalkylurea of 0.001 ~ 30 % by weight.

The topical composition of item 9. according to any one of item 1 ~ 8, wherein, relative to the total amount of compositions, containing the compound with polyoxy alkylidene of 0.01 ~ 20 % by weight.

The topical composition of item 10. according to any one of item 1 ~ 9, it is for moisturizing.

The topical composition of item 11. according to any one of item 1 ~ 9, it is for giving to skin sense of compacting.

12. 1 kinds of methods, its by containing (a) acid mucopolysaccharides to the dermal application of people, (b) have the compound of polyoxy alkylidene and the topical composition of (c) hydroxyalkylurea and carry out moisturizing to skin or to skin imparting moisture feeling, swelling sense or sense of compacting.

The method of item 13. as described in item 12, it is non-therapeutic method.

14. (a) acid mucopolysaccharides, (b) have the compound of polyoxy alkylidene and the combination of (c) hydroxyalkylurea as skin moisturizer or give moisture feeling, swelling sense to skin or the non-therapeutic application of the imparting agent of sense of compacting.

Item 15. (a) acid mucopolysaccharides, (b) have the compound of polyoxy alkylidene and the application being combined in manufacture skin moisturizer or skin is given to moisture feeling, swelling sense or compacted in the imparting agent of sense of (c) hydroxyalkylurea.

Invention effect

Acid mucopolysaccharides is for giving viscosity, performance of keeping humidity and the general composition added in topical composition.On the other hand, the compound with polyoxy alkylidene such as plays a role as nonionic surfactant, therefore general in the composition of topical composition.But add in containing the compositions of acid mucopolysaccharides when having the compound of polyoxy alkylidene, the viscosity that acid mucopolysaccharides has is impaired, and the viscosity being particularly exposed to compositions when heat, light can reduce significantly.

Topical composition of the present invention acid mucopolysaccharides and have polyoxy alkylidene compound basis on further containing hydroxyalkylurea, thus, even if when being exposed to heat, light, the viscosity of compositions reduces and have also been obtained remarkable suppression.Consequently, performance of keeping humidity can be maintained for a long time, moisture feeling, swelling sense, sense of compacting can be given to skin for a long time.Particularly can give sense of compacting.

Accompanying drawing explanation

Fig. 1 is the figure be described the viscosity measurement in embodiment.

Fig. 2 is the figure representing the effect that the viscosity of the composite inhibiting that ethoxy urea brings reduces.The longitudinal axis represents relative viscosity (%).

Fig. 3 is the figure representing the effect that the viscosity of the composite inhibiting that ethoxy urea brings reduces.The longitudinal axis represents relative viscosity (%).

Fig. 4 is the figure representing the effect that the viscosity of the composite inhibiting that ethoxy urea brings reduces.The longitudinal axis represents relative viscosity (%).

Fig. 5 is the figure representing the effect that the viscosity of the composite inhibiting that ethoxy urea brings reduces.The longitudinal axis represents relative viscosity (%).

Fig. 6 is the figure representing the effect that the viscosity of the composite inhibiting that ethoxy urea brings reduces.The longitudinal axis represents relative viscosity (%).

Fig. 7 is the figure representing the effect that the viscosity of the composite inhibiting that ethoxy urea brings reduces.The longitudinal axis represents relative viscosity (%).

Detailed description of the invention

Below the present invention is described in detail.

Topical composition of the present invention has the compound of polyoxy alkylidene and the compositions of (c) hydroxyalkylurea containing (a) acid mucopolysaccharides, (b).

(a) acid mucopolysaccharides

Acid mucopolysaccharides is the polysaccharide containing amino sugar and alduronic acid in its basic framework.As the concrete example of acid mucopolysaccharides, hyaluronic acid, chondroitin sulfate, heparin, Hirudoid, dermatan sulfate, Heparan sulfate and keratan sulfate I and II etc. can be enumerated.

Acid mucopolysaccharides, except natural product, can also be by acid or alkali, enzyme, ultrasound wave or shears such physical property method and decomposed natural product and the derivant of the material that obtains or natural product.

Such as, hyaluronic acid can be by natural polymer hyaluronic acid enzyme such as hydrolysis or use hyaluronidase under the acid that such as hydrochloric acid is such exists is carried out the decomposition hyaluronic acid processing or utilize ultrasound wave or shearing to carry out physical property cut-out and prepare.Decompose hyaluronic acid and can also buy the commercially available products such as ヒ ア ロ オ リ go (Q. P. Corp.).

In addition, as the derivant of natural product, acetylation hyaluronic acid, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid etc. can be enumerated.

Acid mucopolysaccharides can be analyte, their each salt of derivant of natural product, natural product.This salt can be the salt pharmaceutically or biologically allowed, and can enumerate such as: the alkali metal salt that sodium, potassium are such; The alkali salt that magnesium, calcium are such; Zinc salt; Ammonium salt; The alkanolamine etc. that monoethanolamine is such.Wherein, preferred as alkali salt, more preferably sodium salt.

As the preferred concrete example of the salt of acid mucopolysaccharides, hyaluronate sodium can be enumerated, potassium hyaluronate, calcium hyauronate, hyaluronic acid magnesium, Curiosin, hyaluronic acid ammonium, hyaluronic acid monoethanolamine, acetylation hyaluronate sodium, acetylation potassium hyaluronate, acetylation calcium hyauronate, acetylation hyaluronic acid magnesium, acetylation Curiosin, acetylation hyaluronic acid ammonium, acetylation hyaluronic acid monoethanolamine, sodium chondroitin sulfate, chondroitin sulfate potassium, dermatan sulfate sodium, dermatan sulfate potassium, chitosan ascorbic acid, chitosan glycolic, chitosan lactic acid, hydroxypropyltrimethyl ammonium chloride chitosan, Heparan sulfate sodium, Heparan sulfate potassium etc.

Acid mucopolysaccharide apoplexy due to endogenous wind; the acid of preferably clear matter, hyaluronate sodium, chondroitin sulfate, sodium chondroitin sulfate, acetylation hyaluronate sodium, acetylation potassium hyaluronate, acetylation calcium hyauronate, acetylation hyaluronic acid magnesium, acetylation Curiosin; more preferably hyaluronic acid, hyaluronate sodium, chondroitin sulfate, sodium chondroitin sulfate, acetylation hyaluronate sodium, acetylation potassium hyaluronate, acetylation Curiosin, further more preferably hyaluronic acid, hyaluronate sodium.

Acid mucopolysaccharides can be used alone one or combinationally uses two or more.

The source of acid mucopolysaccharides is not particularly limited, and can be spendable acid mucopolysaccharides in the field of pharmaceuticals, medicine part outer article or cosmetics.

The mean molecule quantity of acid mucopolysaccharides is not particularly limited, such as, be about 1000 ~ 4,000,000, be preferably about 1000 ~ 3,000,000, be more preferably 5000 ~ 3,000,000, be particularly preferably about 5000 ~ 2,000,000.

The content of the acid mucopolysaccharides in topical composition is preferably more than 0.000001 % by weight relative to the total amount of compositions, is more preferably more than 0.001 % by weight, is more preferably more than 0.01 % by weight further.When being in this scope, sufficient viscosity and performance of keeping humidity can be given to topical composition.In addition, the content of the acid mucopolysaccharides in topical composition is preferably less than 1 % by weight relative to the total amount of compositions, is more preferably less than 0.5 % by weight, is more preferably less than 0.25 % by weight further.When being in this scope, can suppressing to be clamminess, good use sense can be given.

b () has the compound of polyoxy alkylidene

Polyoxy alkylidene is the functional group represented by following general formula (1).

(O(CH ₂)m)n- (1)

In the functional group represented by above-mentioned formula (1) having in the compound of polyoxy alkylidene used in the present invention, m is such as 1 ~ 4, is preferably 2 ~ 4.Specifically, polyoxymethylene, polyoxyethylene, polyoxypropylene, polyoxy butylidene etc. can be enumerated.

In addition, in above-mentioned formula (1), n is such as 2 ~ 150, is preferably 5 ~ 100, is more preferably 10 ~ 30.

As the compound with polyoxy alkylidene, 1 ~ 3 upper ether linking that can be set forth in typically in three carbon of glycerol has the polyoxy alkylidene glycerin ether of polyoxy alkylidene.Also on the carbon of non-bonding polyoxy alkylidene, fatty acid can be had by ester linkage.

Specifically, polyoxymethylene glycerin ether can be enumerated, polyoxyethylene glycerin ether, polyoxypropylene glycerin ether, polyoxy butylidene glycerin ether, polyoxymethylene polyoxyethylene glycerin ether, polyoxymethylene polyoxypropylene glycerin ether, polyoxymethylene polyoxy butylidene glycerin ether, polyoxyethylene polyoxypropylene glycerin ether, polyoxyethylene polyoxy butylidene glycerin ether, polyoxypropylene polyoxy butylidene glycerin ether, polyoxymethylene polyoxyethylene polyoxypropylene glycerin ether, polyoxymethylene polyoxyethylene polyoxy butylidene glycerin ether, polyoxypropylene polyoxyethylene polyoxy butylidene glycerin ether, polyoxypropylene polyoxymethylene polyoxy butylidene glycerin ether etc.

Wherein, preferably there is the glycerin ether of polyoxy butylidene, more preferably polyoxymethylene polyoxyethylene polyoxy butylidene glycerin ether, polyoxy butylidene polyoxyethylene polyoxypropylene glycerin ether, polyoxypropylene polyoxymethylene polyoxy butylidene glycerin ether, further more preferably polyoxy butylidene polyoxyethylene polyoxypropylene glycerin ether.

As the commercially available product of polyoxy butylidene polyoxyethylene polyoxypropylene glycerin ether, such as ウ ィ Le Block ラ イ De S-753 (You Inc. can be used; Polyoxy butylidene polyoxyethylene polyoxypropylene glycerin ether (3B.O) (8E.O) (5P.O)) etc.

In addition, as the polyoxy alkylidene glycerin ether containing fatty acid residue, distearyl acid polyoxyethylene glyceride, three stearic acid polyoxyethylene glyceride, isostearic acid polyoxyethylene glyceride, three isostearic acid polyoxyethylene glyceride, isostearic acid polyoxyethylene glyceride, two isostearic acid polyoxyethylene glyceride, three isostearic acid polyoxyethylene glyceride, three oleic acid polyoxyethylene glyceride, polyoxyethylene list coconut oil fat acid glyceride etc. can be enumerated.

The compound with polyoxy alkylidene can be used alone one or combinationally uses two or more.

The content with the compound of polyoxy alkylidene in topical composition is preferably more than 0.01 % by weight relative to the total amount of compositions, is more preferably more than 0.05 % by weight, is more preferably more than 0.1 % by weight further.When being in this scope, usually can obtain the effect of the compound with polyoxy alkylidene fully.In addition, the content with the compound of polyoxy alkylidene in topical composition is preferably less than 20 % by weight relative to the total amount of compositions, is more preferably less than 15 % by weight, is more preferably less than 10 % by weight further.When being in this scope, good use sense can be given.

(c) hydroxyalkylurea

Hydroxyalkylurea refer in the hydrogen atom that urea has at least one replaced by hydroxyalkyl after compound.That is, the hydroxyalkylurea described in the present invention is the compound represented by following general formula (2).

R ¹R ²N-CO-NR ³R ⁴(2)

(in formula, R ¹, R ², R ³and R ⁴represent the alkyl of hydrogen atom, carbon number 1 ~ 4 or the hydroxyalkyl of carbon number 2 ~ 6 independently of one another, and R ¹, R ², R ³and R ⁴in at least one be the hydroxyalkyl of carbon number 2 ~ 6)

As hydroxyalkyl, specifically, ethoxy, hydroxypropyl, hydroxyl butyl, dihydroxy butyl, hydroxyl amyl group, hydroxyl hexyl etc. can be enumerated.Wherein, preferred ethoxy.

More specifically, as hydroxyalkylurea, N-(2-ethoxy) urea can be exemplified, N-(2-hydroxypropyl) urea, N-(3-hydroxypropyl) urea, N-(2,3-dihydroxypropyl) urea, N-(2-hydroxyl butyl) urea, N-(3-hydroxyl butyl) urea, N-(4-hydroxyl butyl) urea, N-(2,3-dihydroxy butyl) urea, N-(2,4-dihydroxy butyl) urea, N-(3,4-dihydroxy butyl) urea, N-ethyl-N '-(2-ethoxy) urea, two (2-ethoxy) urea of N, N-, N, N '-bis-(2-ethoxy) urea, two (2-hydroxypropyl) urea of N, N-, N, N '-bis-(2-hydroxypropyl) urea, two (2-ethoxy)-the N '-propyl group urea of N, N-, N, N '-bis-(2-hydroxypropyl)-N '-(2-ethoxy) urea, the N-tert-butyl group-N '-(2-ethoxy)-N '-(2-hydroxypropyl) urea, two (2-the ethoxy)-N ' of N, N-, N '-dimethyl urea, N, N, N ', N '-four (2-ethoxy) urea and two (2-ethoxy)-N ', N '-bis-(2-hydroxypropyl) ureas of N, N-etc.

The number of the hydroxyalkyl of hydroxyalkylurea is preferably 1 ~ 3, is more preferably 1 ~ 2, is more preferably 1 (monohydroxyalkyl group urea) further.Wherein, preferred ethoxy urea.

Hydroxyalkylurea can be used alone one or combinationally uses two or more.

The content of the hydroxyalkylurea in topical composition is preferably more than 0.001 % by weight relative to the total amount of compositions, is more preferably more than 0.01 % by weight, is more preferably more than 0.1 % by weight further.When being in this scope, effect of the present invention (the imparting performance of the viscosity of composite inhibiting, performance of keeping humidity, moisture feeling and sense of compacting through time reduce) can be obtained fully.In addition, the content of the hydroxyalkylurea in topical composition is preferably less than 30 % by weight relative to the total amount of compositions, is more preferably less than 20 % by weight, is more preferably less than 10 % by weight further.When being in this scope, the effect of above-mentioned the present application can be obtained fully.

In addition, the content of hydroxyalkylurea is preferably more than 0.0001 weight portion, is more preferably more than 0.01 weight portion, is more preferably more than 0.1 weight portion further relative to compound 1 weight portion with polyoxy alkylidene relative to the ratio of content of the compound with polyoxy alkylidene.When being in this scope, effect of the present invention (the imparting performance of the viscosity of composite inhibiting, performance of keeping humidity, moisture feeling and sense of compacting through time reduce) can be obtained fully.In addition, the content of hydroxyalkylurea is preferably below 500 weight portions, is more preferably below 200 weight portions, is more preferably below 100 weight portions further relative to compound 1 weight portion with polyoxy alkylidene relative to the ratio of content of the compound with polyoxy alkylidene.When being in this scope, the effect of above-mentioned the present application can be obtained fully.

In addition, the content of hydroxyalkylurea is preferably more than 0.01 weight portion, is more preferably more than 1 weight portion, is more preferably more than 10 weight portions further relative to acid mucopolysaccharides 1 weight portion relative to the ratio of the content of acid mucopolysaccharides.When being in this scope, effect of the present invention (the imparting performance of the viscosity of composite inhibiting, performance of keeping humidity, moisture feeling and sense of compacting through time reduce) can be obtained fully.In addition, the content of hydroxyalkylurea is preferably below 10000 weight portions, is more preferably below 500 weight portions, is more preferably below 100 weight portions further relative to acid mucopolysaccharides 1 weight portion relative to the ratio of the content of acid mucopolysaccharides.When being in this scope, the effect of above-mentioned the present application can be obtained fully.

preparation

For topical composition of the present invention, base operable in the composition of (a) ~ (c) of above-mentioned explanation and cosmetics or carrier and additive as required, other effective ingredient can be mixed together and making case as topical composition used for cosmetic.

The character of compositions is not particularly limited, liquid, flowing shape or the preparation of semisolid shape can be made, can making case as preparations such as liquor, suspension, Emulsion, ointment, ointment, gel, liniment, lotion, aerosol agent, the membrane that makes medicinal liquid be immersed in non-woven fabrics obtains.Wherein, preferred Emulsion, ointment, emulsion, ointment, gel, lotion, particularly preferably ointment, emulsion, ointment, gel.

The concrete purposes of cosmetics is not particularly limited, and can enumerate the basic cosmetics that astringent, emulsion, gel, cream, beautifying liquid, Sun block cosmetics, Pack (pack), facial film (mask), hand cream, skin cream, emollient cream are such; The such washing of clean product, cleansing product, bath foam, shampoo, hair conditioner, maintenance product applies some make up; The makeup cosmetic etc. such as end adornment, various powder enamel.

base or carrier

As base or carrier, can enumerate: the hydrocarbon that paraffin, liquid paraffin, squalane, white beeswax, Ultralube W 389 (プ ラ ス チ ベ ー ス etc.), ceresine, ceresin, vaseline, tristearin, microwax, alpha-olefin low polymers, liquid paraffin,light are such, the fatty acid that lauric acid, myristic acid, Palmic acid, stearic acid, behenic acid, isostearic acid are such, the triglyceride that three 2 ethyl hexanoic acid glyceride (tricaprylin), three (caprylic/capric) glyceride are such, the higher alcohol that spermol, stearyl alcohol, behenyl alcohol are such, methyl polysiloxane, high polymeric MAO polysiloxanes, dimethylsiloxane methyl (polyoxyethylene) siloxanes methyl (polyoxypropylene) silicone copolymers, dimethylsiloxane methyl (polyoxyethylene) silicone copolymers, dimethylsiloxane methyl (polyoxypropylene) silicone copolymers, polyoxyethylene methyl polysiloxane copolymer, poly-(oxygen ethylidene oxygen propylidene) methyl polysiloxane copolymer, dimethylsiloxane methyl cetyl oxygen radical siloxane copolymer, dimethylsiloxane methyl stearic oxygen radical siloxane copolymer, alkyl acrylate copolymer methyl polysiloxane ester, cross-linking type methyl polysiloxane, cross-linking type methyl phenyl silicone, crosslinked polyether modified silicone, cross-linking type alkyl, polyether modified silicone, the alkyl-modified silicone of cross-linking type, decamethylcyclopentasiloxane, ethyl trisiloxanes, methyl gathers trimethicone, methylsiloxane network polymers, polyoxyethylene methyl polysiloxane copolymer, polymethyl hydrogen siloxane, triethoxysilylethyl polydimethylsiloxanes ethylhexyl polydimethylsiloxane, the silicone oil that dimethyl polysiloxane is such, the ethyl glycol acetate that ethylene glycol acetate, ethylene acetate, triethylene glycol diacetate esters, hexanediol diacetate esters and 2-methyl-2-propylene-1,1-glycol diacetate are such, the diol ester that triethylene glycol divalerate, 2,2,4-trimethyl-1,3-pentanediol mono isobutyrates, 2,2,4-trimethyl-1,3-pentanediol diisobutyrates are such, glycol diacrylate, diethylene glycol diacrylate, propanediol monoacrylate, 2,2-dimethyl-trimethylene diacrylate and the such butanediol acrylate of 1,3 butylene glycol diacrylate, the glycol dinitrate that dinitroglycol, diethylent glycol dinitrate, triethylene glycol dinitrate and Propylene Glycol Dinitrate are such, 2,2 '-[Isosorbide-5-Nitrae-phenylene dioxy base] diethanol, the cellulose derivative that ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose are such, polyvinylpyrrolidone, carrageenan, polyvinyl butyral resin, Polyethylene Glycol, dioxane, butanediol adipate polyester, the esters that isopropyl myristate, myristic acid octyldodecyl, isopropyl palmitate, cetin, isononyl isononanoate, four 2 ethyl hexanoic acid pentaerythritol esters are such, the polysaccharide that dextrin, maltodextrin are such, the lower alcohol that ethanol, isopropyl alcohol are such, the glycol ethers that glycol monoethyl ether, ethylene glycol monoethyl ether, ethylene glycol ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, Diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, dihydroxypropane single-ether, propylene glycol monopropyl ether, DPE, dipropylene glycol monopropyl ether are such, the water system bases etc. such as water.

Wherein, preferred hydrocarbons (particularly alpha-olefin low polymers, squalane, liquid paraffin,light, liquid paraffin), triglyceride (particularly three 2 ethyl hexanoic acid glyceride, three (caprylic/capric) glyceride), higher alcohol (particularly spermol, stearyl alcohol, behenyl alcohol), silicone oil (particularly methyl polysiloxane, alkyl acrylate copolymer methyl polysiloxane ester, cross-linking type methyl polysiloxane, decamethylcyclopentasiloxane, ethyl trisiloxanes, methyl gathers trimethicone, methylsiloxane network polymers, polyoxyethylene methyl polysiloxane copolymer, polymethyl hydrogen siloxane, triethoxysilylethyl polydimethylsiloxanes ethylhexyl polydimethylsiloxane, dimethyl polysiloxane), esters (particularly isononyl isononanoate, four 2 ethyl hexanoic acid pentaerythritol esters), polysaccharide (particularly dextrin, maltodextrin), glycol ethers (particularly diethylene glycol monoethyl ether), water.

Base or carrier can be used alone one or combinationally use two or more.

additive

In topical composition of the present invention, can be added in the scope not damaging effect of the present invention add in cosmetics known additive, such as antioxidant, surfactant, thickening agent, preservative agent, pH adjusting agent, stabilization agent, stimulation palliative, antiseptic, coloring agent, spice and pearly-lustre imparting agent etc.

As antioxidant, dibenzylatiooluene, butylated hydroxyanisole (BHA), sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivates, tocopherol, Tocopheryl derivatives, arabo-ascorbic acid, L-cysteine hydrochloride etc. can be enumerated.

As surfactant, can enumerate such as: the sorbitan fatty acid ester class that sorbitan list isostearate, Span-20, sorbitan monopalmitate, sorbitan monostearate, five-2 ethyl hexanoic acid two glycerol sorbitan ester, four-2 ethyl hexanoic acid two glycerol sorbitan ester are such; The fatty acid propylene glycol ester class that propylene glycolmonostearate is such; Glycerol alkyl ether; Alkyl androstanediol; The amine that stearylamine, oleyl amine are such; The organosilicone surfactants etc. that polyoxyethylene methyl polysiloxane copolymer, lauryl KF-6028, KF-6028 are such.

As thickening agent, such as guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, CVP Carbopol ETD2050, acrylic arid methacrylic acid alkyl ester copolymer, Polyethylene Glycol, bentonite, alginic acid, Polyethylene Glycol (Macrogol) and cellulose thickener (methylcellulose, ethyl cellulose, hydroxyethyl-cellulose, hydroxy methocel, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, carboxymethyl cellulose and carboxyethyl cellulose etc.) and their salt etc. can be enumerated.

As antiseptic, preservative agent, benzoic acid, sodium benzoate, dehydroactic acid, dehydro sodium acetate, p-Hydroxybenzoic acid isobutyl ester, p-Hydroxybenzoic acid isopropyl ester, butyl p-hydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, methyl parahydroxybenzoate, phenyl phenol, benzyl alcohol, methaform, sorbic acid and salt thereof, chlorhexidine gluconate, alkanediol and fatty glyceride etc. can be enumerated.

As pH adjusting agent, mineral acid (hydrochloric acid, sulphuric acid etc.), organic acid (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate etc.), inorganic base (potassium hydroxide, sodium hydroxide etc.), organic base (triethanolamine, diisopropanolamine (DIPA), triisopropanolamine etc.) etc. can be enumerated.

As stabilization agent, sodium polyacrylate, dibenzylatiooluene, butylated hydroxyanisole (BHA), edetate etc. can be enumerated.

As stimulation palliative, Radix Glycyrrhizae extract, sodium alginate etc. can be enumerated.

Additive can be used alone one or combinationally uses two or more.

other effective ingredient

Topical composition of the present invention can contain other effective ingredient in the scope not damaging effect of the present invention.As the concrete example of effective ingredient, such as moisturizing ingredient, anti-inflammatory component, antimicrobial component, vitamins, peptide or derivatives thereof, cell activation composition, aging resistance composition, blood circulation can be enumerated and promote composition, keratolytic ingredient, whitening composition, converge and grade.

As moisturizing ingredient, can enumerate: the macromolecular compound that collagen protein, elastin laminin, keratin, chitin, chitosan are such; The nature moisturizing factor that sodium lactate, carbamide, pyrrolidone sodium carboxylate are such; The lipid that ceramide, cholesterol, phospholipid are such; The plant extract etc. that Flos Matricariae chamomillae extract, hamamelis extract, tea extract, Folium perillae extract are such.

As anti-inflammatory component, the composition, allantoin, glycyrrhizic acid or derivatives thereof, zinc oxide, pyridoxine hydrochloride, tocopherol acetas, salicylic acid or derivatives thereof, episilon amino caproic acid etc. that derive from plant (such as Bellis perennis) can be enumerated.

As antibacterial or sterilization component, can enumerate ethanol, chlorhexidine, salicylic acid, benzalkonium chloride, ethacridine, sulfur, resorcinol, benzethonium chloride, adapalene, benzoyl peroxide, clindamycin, cresol, gluconic acid and derivant thereof, povidone iodine, potassium iodide, iodine, isopropyl methyl phenol, triclocarban, triclosan, photosensitive plain No. 101, photosensitive plain No. 201, p-Hydroxybenzoate, phenyl phenol, 1,2-pentanediol, salt dialkylaminobenzoic acid diaminourea glycine, chlorhexidine gluconate, p-phenolsulfonic acid's zinc etc.

As vitamins, can enumerate: the retinoids such as the retinol derivatives such as retinol, retinyl acetate, retinyl palmitate, retinal, tretinoin, tretinoin methyl ester, tretinoin ethyl ester, tretinoin retinol ester, d-Delta-Tocopherol retinoic acid ester, alpha-tocopherol retinoic acid ester, betatocopherol retinoic acid ester; The vitamin E classes such as dl-alpha-tocopherol, dL-alpha-tocopherol acetate, dl-alpha-tocofecol succinic acid ester, dl-alpha-tocofecol succinic acid calcium; The vitamin B2 classes such as riboflavin, flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), Riboflavine Tertrabutyrate, Riboflavin Tetrabutyrate, riboflavin 5 '-sodium phosphate, riboflavin four nicotinate; The nicotinic acid classes such as DL-Tocopheryl Nicotinate, benzyl nicotinate, methyl nicotinate, nicotinic acid Beta-Butoxy ethyl ester, nicotinic acid 1-(4-aminomethyl phenyl) ethyl ester; The vitamin c class such as ascorbigen-A, ascorbyl stearate, ascorbyl palmitate, two Palmic acid L-AA esters; The vitamin D classes such as hesperidin methyl, ergocalciferol and cholecalciferol; The vitamin K such as phylloquinone, farnoquinone class, gamma oryzanol, dibenzoylthiamine element, dibenzoyl thiamine; The vitamin B1 classes such as thiamine salt hydrochlorate, thiamine cetyl hydrochlorate, thiamine rhodanate, thiamine lauryl hydrochlorate, thiamine nitrate, thiamine monophosphate, thiamine lysinate, thiamine triphosphate, thiamine phosplate phosphate, thiamine phosplate, thiamine bisphosphate, thiamine bisphosphate hydrochlorate, thiamine triguaiacyl phosphate, thiamine triguaiacyl phosphate monophosphate; The vitamin B6 classes such as pyridoxine hydrochloride, acetic acid pyridoxol, pyridoxal hydrochloride, P5P, hydrochloric acid pyridoxamine; The vitamin B12 classes such as cobalamin, hydroxocobalamin, deoxyadenosine cobalt amine; The folic acid such as folic acid, pteroylglutamic acid class; The nicotinic acid such as nicotinic acid, nicotiamide class; The pantothenic acid class such as pantothenic acid, calcium pantothenate, pantothenylol (panthenol), D-pantetheine (D-パ Application テ サ イ Application), D-pantethine, coenzyme A, pantothenyl ethyl ether; The biotin classes such as biotin, biotin complex of yeast. (PVC オ チ シ Application); Ascorbic acid, sodium ascorbate, hydroascorbic acid, NAP, magnesium L-ascorbyl-2-phosphate etc. are as the vitamin c class of ascorbic acid derivates; The vitaminoid action factors etc. such as carnitine, ferulic acid, alpha-lipoic acid, orotic acid.

As peptide or derivatives thereof, keratin can be enumerated and decompose peptide, hydrolysis of keratin, collagen protein, derive from the collagen protein of fish, remove atelocollagen albumen, gelatin, elastin laminin, elastin laminin decomposes peptide, collagen protein decomposes peptide, hydrolytic collagen, hydroxypropyl ammonium chloride hydrolytic collagen, elastin laminin decomposes peptide, conchiolin decomposes peptide, hydrolysis conchiolin, fibroin decomposes peptide, hydrolyzed silkworm silk, lauroyl hydrolyzed silkworm silk sodium, soybean protein decomposes peptide, hydrolyzed soybean protein, wheat protein, wheat protein decomposes peptide, hydrolyzed wheat protein, caseinolytic peptide, acylated peptide (palmityl oligopeptide, Matrixyl, Palmitoyl Tetrapeptide etc.) etc.

As cell activation composition, can enumerate: the vitaminss such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid class; The Alpha-hydroxy such as glycolic, lactic acid acids; Tannic acid, flavonoid, saponin, allantoin, photosensitive plain No. 301 etc.

As aging resistance composition, pangamic acid, kinetins, ursolic acid, Radix Curcumae extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone etc. can be enumerated.

As blood circulation facilitation composition, can enumerate: derive from plant (such as Radix Ginseng, angelica keiskei koidzumi, Arnica montana, Semen Ginkgo, Fructus Foeniculi, Herba Rabdosiae glaucocalycis, Holland Oak Tree, Flos Matricariae chamomillae, Rome Flos Matricariae chamomillae, Radix Dauci Sativae, Radix Gentianae, Fructus Arctii, rice, Fructus Crataegi, Lentinus Edodes, Mespilus germinica Linn, the West Juniperus rigida Sieb.et Zucc., Rhizoma Chuanxiong, work as medicine, Herba thymi vulgaris, Flos Caryophylli, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Semen Persicae, Pericarpium Citri junoris, Radix Ginseng, Bulbus Allii, butchers broom, Fructus Vitis viniferae, Paeonia suffruticosa, Aesculus chinensis Bunge, Herba leucadis ciliatae, Fructus Citri grandis, Semen Coicis, Herba Rosmarini Officinalis, Rosehips, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Pericarpium Citri junoris, Fructus Persicae, Fructus Pruni, Semen Juglandis, Semen Maydis) composition, glucityl Hesperidin etc.

As keratolytic ingredient, salicylic acid, glycolic, fruit acid, phytic acid, sulfur etc. can be enumerated.

As whitening composition, ascorbic acid and its derivant, arbutin, tocopherol etc. can be enumerated.

As astringent component, p-phenolsulfonic acid's zinc, zinc oxide, menthol, ethanol etc. can be enumerated.

Other effective ingredient can be used alone one or combinationally use two or more.

using method

The using method of topical composition of the present invention is different according to the skin condition, age, Do etc. of use object, can adopt such as following methods.That is, one day for several times (such as, about 1 ~ 5 time, be preferably 1 ~ 3 time) will appropriate (such as, about 0.05g ~ about 5g) application (be coated with, spray, attach) on skin.In addition, to make one day use amount of acid mucopolysaccharides such as the mode set of applications compound of about 0.00005g ~ about 0.025g.

Topical composition of the present invention also can be applied to any skin of face, cervical region, hands, foot, finger, trunk, scalp etc.

purposes

Topical composition of the present invention can making case as moisturizing or for skin give moisture feeling, swelling sense or compact sense topical composition.

Sense of compacting refers to following state: launch the preparation coated on skin so that after rubbing skin lightly with finger or palm, the preparation remaining coating residues in the sensation pointed between skin, and has the absorption sense that the skin being coated with preparation when the finger launched by preparation or palm leave from skin is adsorbed in this finger or palm.

The present invention comprises by topical composition application (be coated with, spray, attach) of the present invention containing (a) acid mucopolysaccharides, (b) with the compound of polyoxy alkylidene and the above-mentioned explanation of (c) hydroxyalkylurea is carried out the method for moisturizing to skin in the skin of the face, cervical region, hands, foot, finger, body, scalp etc. of people and given moisture feeling, swelling sense or the method for sense of compacting to skin.These methods can be non-therapeutic method.

The using method of the topical composition of the present invention in these methods is as illustrated by topical composition of the present invention.

In addition, the present invention comprises (a) acid mucopolysaccharides, (b) have the compound of polyoxy alkylidene and the combination of (c) hydroxyalkylurea as skin moisturizer with give moisture feeling, swelling sense to skin or the non-therapeutic application of the imparting agent of sense of compacting.

In addition, the present invention comprises (a) acid mucopolysaccharides, (b) has the compound of polyoxy alkylidene and (c) hydroxyalkylurea is combined in the application manufacturing skin moisturizer and skin is given to moisture feeling, swelling sense or compacted in the imparting agent of sense.

The using method of the composition of these preparations, dosage form and preparation is as illustrated by topical composition of the present invention.

Embodiment

Below, enumerate embodiment and the present invention is described in more detail, but the present invention is not limited to these embodiments.

test example 1 (heat stabilization test)

(1) preparation of compositions

The composition of each embodiment and comparative example is shown in following table 1 and table 2.It should be noted that, the numerical value in table 1 and table 2 all represents % by weight.

[table 1]

[table 2]

(2) test method

(viscosimetric analysis)

Preparation has the embodiment of composition shown in table 1 and table 2 and each compositions of comparative example.

For both sample after the firm preparation of each compositions and article in custody (at the sample of 60 DEG C of keepings after one week), leave standstill after 12 hours under the condition of 25 DEG C ± 1 DEG C, carry out viscosimetric analysis.Reduce about viscosity, the viscosity after just preparing is set to 100%, represents the viscosity of article in custody (60 DEG C of keepings one week) by relative viscosity.That is, the relative viscosity of each compositions is calculated by following formula.

Relative viscosity (%)

=(viscosity after the viscosity/just preparation of article in custody (60 DEG C, a week)) × 100

Viscosimetric analysis condition is as described below.

According to the test method(s) of " (2) circular cone-dull and stereotyped rotating cylinder viscometer (the cone plate type viscometer) " recorded in the 16th edition Japanese Pharmacopoeia ordinary test method viscosimetry the 2nd method rotating cylinder viscometer method, RE85 (eastern machine industry) is used to measure viscosity.That is, measuring temperature is under the condition of 25 DEG C ± 1 DEG C, in mensuration, till measuring the viscosity to 3 minute of each minute, uses the meansigma methods of three times.

Substantially as shown in Figure 1, sample is put into the gap of the angle [alpha] between circular cone 1 and flat plectane 2, circular cone 1 or flat plectane 2 are rotated with constant angular velocity omega or torque T, measure torque or angular velocity that flat plectane 2 when reaching stable state or circular cone 1 be subject to, calculated the viscosities il of sample by following formula.

η＝100×(3α/2πR3)·(T/ω)

η: viscosity (mPas) (Pas=103mPas) of sample

α: flat plectane 2 and circular cone 1 angulation (rad)

π: pi

R: the radius (cm) of circular cone

T: the torque (10-7Nm) acting on flat plectane 2 or 1, circular cone

ω: angular velocity (rad/s)

(use sense test)

The embodiment used in viscosity test for test 1 and the compositions of comparative example, three syndics drip each compositions of 0.5ml inside front wrist, sprawl into the scope of 2cm × 2cm, after 5 minutes, according to the evaluation criterion evaluation " sense of compacting " of following use sense index.

5: quite have " sense of compacting ".

4: have " sense of compacting ".

3: generally speaking have " sense of compacting ".

2: less have " sense of compacting ".

1: do not have " sense of compacting ".

(3) result of the test

(viscosimetric analysis)

The measurement result of viscosity is shown in Fig. 2 ~ 5.

Can be clear and definite by Fig. 2 ~ 5, containing hyaluronate sodium and polyoxy butylidene polyoxyethylene polyoxypropylene glycerin ether (3B.O) (8E.O) (5P.O), not containing the comparative example 1 ~ 4 of ethoxy urea compositions through time viscosity reduce significantly, but for be combined with wherein ethoxy urea embodiment 1 ~ 6 compositions for, through time viscosity reduce all obtain remarkable suppression.

(use sense test)

Show the result in following table 3.Compare the change of " sense of compacting " of just preparing rear and article in custody (60 DEG C of keepings one week), result, in either event, the use sense index of embodiment is all higher than the use sense index of comparative example.Confirm " sense of compacting " that the suppression that brings produces because of heat ageing by coordinating ethoxy urea and reduce such effect.

[table 3]

test example 2 (photo-stability testing)

(1) preparation of compositions

The composition of each embodiment and comparative example is shown in following table 4.It should be noted that, the numerical value in table 4 all represents % by weight.

[table 4]

(2) test method

(viscosimetric analysis)

Preparation has the embodiment of composition shown in table 4 and each compositions of comparative example.

The capacity that each compositions is filled into respectively is in the glass container of 30mL, and the viscosity at measuring 25 DEG C, as initial viscosity.Then, SUNTEST XLS+ (Toyo Seiki makes institute) is utilized to carry out being equivalent to 10000kJ/m ²illumination penetrate, then measure the viscosity at 25 DEG C immediately.

Do not irradiate sample and irradiate sample viscosimetric analysis separately and implement under 25 DEG C ± 1 DEG C condition.Viscosimetric analysis condition is identical with test example 1.Reduce about viscosity, the viscosity of not irradiating sample is set to 100%, represents postradiation viscosity by relative viscosity.That is, the relative viscosity of each compositions is calculated by following formula.

Relative viscosity (%)=(irradiating the viscosity of viscosity/the do not irradiate sample of sample) × 100

(use sense test)

For the embodiment used in the viscosity test of test 2 and comparative example, three syndic three people drip each compositions of 0.5ml inside front wrist, sprawl into the scope of 2cm × 2cm, after 5 minutes, according to the evaluation criterion evaluation " sense of compacting " of following use sense index.The method of use sense test is identical with test example 1.

(3) result of the test

(viscosimetric analysis)

The result of viscosimetric analysis is shown in Fig. 6 and Fig. 7.Can be clear and definite by Fig. 6 and Fig. 7, containing hyaluronate sodium and polyoxy butylidene polyoxyethylene polyoxypropylene glycerin ether (3B.O) (8E.O) (5P.O), not containing the comparative example 2 and 5 of ethoxy urea compositions through time viscosity reduce significantly, but for be combined with wherein ethoxy urea embodiment 7 and 8 compositions for, through time viscosity reduce all obtain remarkable suppression.

(use sense test)

Show the result in following table 5.Compare ultraviolet radiation sample, the change of " sense of compacting " of not irradiating sample, result, in either event, the use sense index of embodiment is all higher than the use sense index of comparative example.Confirm " sense of compacting " that the suppression that brings produces because of heat ageing by coordinating ethoxy urea and reduce such effect.

[table 5]

formulation Example

Below, the concrete Formulation Example of topical composition of the present invention is exemplified.The unit of the content of the composition of Formulation Example is " % by weight ".

formulation Example 1 skin lotion

formulation Example 2 emulsion

formulation Example 3 gel emulsifiable paste

formulation Example 4 emulsion

Microcapsule containing organic fluorescence agent is the microcapsule that the method recorded in the embodiment 1 by WO2012/102397 makes.

formulation Example 5 gel astringent

Microcapsule containing organic fluorescence agent is the microcapsule that the method recorded in the embodiment 1 by WO2012/102397 makes.

formulation Example 6 cosmetic gel liquid

Microcapsule containing organic fluorescence agent is the microcapsule that the method recorded in the embodiment 2 by WO2012/102397 makes.

formulation Example 7 emulsion

Microcapsule containing organic fluorescence agent is the microcapsule that the method recorded in the embodiment 2 by WO2012/102397 makes.

formulation Example 8 emulsifiable paste

Microcapsule containing organic fluorescence agent is the microcapsule that the method recorded in the embodiment 3 by WO2012/102397 makes.

formulation Example 9 emulsifiable paste

Microcapsule containing organic fluorescence agent is the microcapsule that the method recorded in the embodiment 4 by WO2012/102397 makes.

Utilizability in industry

Topical composition of the present invention inhibit acid mucopolysaccharides through time viscosity reduce, the sticking good use sense of tool can be maintained chronically.In addition, accompany therewith, performance of keeping humidity and the reduction to skin imparting moisture feeling or the performance felt of compacting have also been obtained suppression.Like this, for topical composition of the present invention, the characteristic of acid mucopolysaccharides can not be deteriorated because circulating, preserving, and is therefore the product that commodity value is high.

Claims (15)

1. a topical composition, it contains (a) acid mucopolysaccharides, (b) has the compound of polyoxy alkylidene and (c) hydroxyalkylurea.

2. topical composition as claimed in claim 1, wherein, hydroxyalkylurea is N-(2-ethoxy) urea.

3. topical composition as claimed in claim 1 or 2, wherein, acid mucopolysaccharides is selected from the group be made up of hyaluronic acid and chondroitin sulfate and their salt.

4. the topical composition according to any one of claims 1 to 3, wherein, the compound with polyoxy alkylidene is polyoxy butylidene polyoxyethylene polyoxypropylene glycerol.

5. the topical composition according to any one of Claims 1 to 4, wherein, relative to compound 1 weight portion with polyoxy alkylidene, the hydroxyalkylurea containing 0.0001 ~ 2000 weight portion.

6. the topical composition according to any one of Claims 1 to 5, wherein, relative to acid mucopolysaccharides 1 weight portion, the hydroxyalkylurea containing 0.01 ~ 10000 weight portion.

7. the topical composition according to any one of claim 1 ~ 6, wherein, relative to the total amount of compositions, containing the acid mucopolysaccharides of 0.000001 ~ 1 % by weight.

8. the topical composition according to any one of claim 1 ~ 7, wherein, relative to the total amount of compositions, containing the hydroxyalkylurea of 0.001 ~ 30 % by weight.

9. the topical composition according to any one of claim 1 ~ 8, wherein, relative to the total amount of compositions, containing the compound with polyoxy alkylidene of 0.01 ~ 20 % by weight.

10. the topical composition according to any one of claim 1 ~ 9, it is for moisturizing.

11. topical compositions according to any one of claim 1 ~ 9, it is for giving to skin sense of compacting.

12. 1 kinds of methods, its by containing (a) acid mucopolysaccharides to the dermal application of people, (b) have the compound of polyoxy alkylidene and the topical composition of (c) hydroxyalkylurea and carry out moisturizing to skin or give moisture feeling, swelling sense or sense of compacting to skin.

13. methods as claimed in claim 12, it is non-therapeutic method.

14. (a) acid mucopolysaccharides, (b) have the compound of polyoxy alkylidene and the combination of (c) hydroxyalkylurea as skin moisturizer or give moisture feeling, swelling sense to skin or the non-therapeutic application of the imparting agent of sense of compacting.

15. (a) acid mucopolysaccharides, (b) have the compound of polyoxy alkylidene and the application being combined in manufacture skin moisturizer or skin is given to moisture feeling, swelling sense or compacted in the imparting agent of sense of (c) hydroxyalkylurea.