CN104771637A - Cholagogic and lithagogue agent for treating gallstone and preparation method thereof - Google Patents
Cholagogic and lithagogue agent for treating gallstone and preparation method thereof Download PDFInfo
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- CN104771637A CN104771637A CN201510193343.9A CN201510193343A CN104771637A CN 104771637 A CN104771637 A CN 104771637A CN 201510193343 A CN201510193343 A CN 201510193343A CN 104771637 A CN104771637 A CN 104771637A
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- cholagogic
- lithagogue
- herba
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- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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Abstract
The invention discloses a cholagogic and lithagogue agent for treating a gallstone. The cholagogic and lithagogue agent is prepared from the following raw materials in parts by weight: 13-18 parts of cynanchum paniculatum, 11-16 parts of silybum marianum, 8-15 parts of cattail pollen, 6-9 parts of trogopterus dung, 10-16 parts of semen cuscutae, 12-17 parts of corn stigma, 9-16 parts of immature bitter orange, 11-16 parts of honeysuckle stem, 9-15 parts of amaranthus viridis, 12-18 parts of pericarpium citri reticulatae, 13-20 parts of glechoma longituba and 10-14 parts of szechwan Chinaberry fruit. The cholagogic and lithagogue agent has the excellent effects that the traditional medicine property is organically combined with the modern pharmacology of the traditional Chinese medicine; and by use of the synergistic effects of the medicinal materials, the cholagogic and lithagogue agent plays roles in clearing away heat and toxic materials, protecting the liver, benefiting the gallbladder, resisting inflammation and dissolving the stone, and has a significant curative effect on the gallstone. The cholagogic and lithagogue agent is capable of obviously improving the clinical symptoms of patients and relieving the pain, and has the efficacies of being short in treatment course, fast in action effect, and free of relapse of healed gallstone.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of cholagogic and lithagogue agent and preparation method for the treatment of cholelithiasis.
Background technology
Gallstone disease is a kind of common, multiple digestive system disease, is one of common acute abdomen.In China's gallstone disease prevalence in ascendant trend faster, some areas reach 10%, close to the Incidence level of World Developed Countries cholelithiasis 10%-15%.Its case fatality rate accounts for the first place of surgery inpatient, is the important death cause of acute abdomen, serious harm people's health.
Calculus is at present based on operative treatment, and especially laparoscopic surgery, but relapse rate is higher, operating difficulty and risk will increase again, therefore occur that surgical operation can not solve the viewpoint of cholelithiasis problem, and patient has the feared state of mind to operation.Western medicine calculus curative effect is not good enough, and side effect is large, and expensive, so adopt treatment by Chinese herbs calculus to be more and more necessary.Along with to bile chemistry, the biochemical further investigation of bile acid, disclose Bile acid and change internal relation in gall-stone formation, promoted the progress of dissolved stone medicine and litholytic therapy.Chinese medicine thinks that the etiology and pathogenesis of primary disease has disorder of emotion to cause QI depression of the liver and gallbladder, the liver failing to maintain the normal flow of QI, courage pent-up; Or wound, operation hindered, cause congestion internal resistance, stagnation of QI and blood, affect suffocating of liver and gall function, make nitrogen disorder in ascending and descending, bile catharsis is not normal, and with the passing of time pent-up, form sandstone; Experience damp and hot heresy, or delicious food of being addicted to drink, change raw damp and hot, or insufficiency of the spleen damp-stagnancy and heat-transformation, damp and hotly accumulate steaming, make the disorder in ascending and descending of gallbladder, cholestegnosis, form stone for a long time.
Application publication number CN 103301392 A(application number 201210067648.1) Chinese invention patent document disclose a kind of powder for the treatment of cholelithiasis, be made up of the raw material of following weight portion: Spora Lygodii 50-60 part, Endothelium Corneum Gigeriae Galli 50-60 part, Radix Curcumae 30-35 part, Herba Lysimachiae 100-200 part, Fructus Toosendan 30-40 part, Talcum 30-35 part, Semen Abutili 30-35 part.Application publication number CN 102670997 A(application number 201210114321.5) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of cholelithiasis, be made up of the raw material of following weight parts: Cornu Saigae Tataricae powder 0.5-0.7, Concha Haliotidis 28-32, Radix Achyranthis Bidentatae 13-17, Radix Scutellariae 13-17, Radix Paeoniae Rubra 10-14, Radix Paeoniae Alba 10-14, Fructus Atriplicis Sibiricae 13-17, Spica Prunellae 10-14, Rhizoma Alismatis 13-17, Radix Bupleuri (processed with vinegar) 13-17, Fructus Aurantii 10-14, Fructus Aurantii Immaturus 10-14, Flos Inulae 8-12, Rhizoma Gastrodiae 8-12, semen arecae 8-12, Pericarpium Arecae 8-12, Haematitum 18-22, Rhizoma Pinelliae Preparata 8-10, Radix Codonopsis 8-12, Fructus Toosendan 8-12, Rhizoma Corydalis 8-12, Oletum Trogopterori 5-7, Herba Lysimachiae 28-32.Application publication number CN 102641471 A(application number 201210120000.6) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of cholelithiasis, be made up of the component of the material medicine proportioning of following weight: Radix Astragali 30-50g, Rhizoma Sparganii 15-20g, Rhizoma Curcumae 15-20g, Radix Bupleuri 15-20g, Pericarpium Citri Reticulatae Viride 15-20g, Radix Curcumae 20-25g, Herba Lysimachiae 200-230g, Endothelium corneum 30-35g, Folium Pyrrosiae 30-35g, Asteriscus Pseudosciaenae 15-20g, Radix Et Rhizoma Rhei 6-10g, Herba Artemisiae Scopariae 30-35g, Carapax Trionycis (processed) 30-35g.
Current cholelithiasis along with the application of the technology such as ultrasonic, scope, intervention, radiation, makes the treatment of cholelithiasis have new way in treatment.Rubble, lithodialysis, calculus and operative treatment have had remarkable progress, but all there is self inevitable defect.Therefore, try to explore safely and effectively that Therapeutic Method is imperative.Shown by Clinical and experimental study, Chinese medicine cholelithiasis not only good effect, price is low, toxic and side effects is few, and to be easy to accept by extensive patients.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, safe and effective, effect and treat the cholagogic and lithagogue agent of cholelithiasis rapidly.Curative effect of medicine of the present invention is definite, cure rate is high, does not recur more.
Technical scheme of the present invention is:
The cholagogic and lithagogue agent for the treatment of cholelithiasis, is prepared from by following bulk drugs, is weight portion: Radix Cynanchi Paniculati 13-18; Herba Silybi mariani 11-16; Pollen Typhae 8-15; Oletum Trogopterori 6-9; Semen Cuscutae 10-16; Stigma Maydis 12-17; Fructus Aurantii Immaturus 9-16; Caulis Lonicerae 11-16; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 9-15; Pericarpium Citri Reticulatae 12-18; Herba Glechomae 13-20; Fructus Toosendan 10-14.
In preferred scheme, Radix Cynanchi Paniculati 14-17; Herba Silybi mariani 13-14; Pollen Typhae 10-13; Oletum Trogopterori 7-8; Semen Cuscutae 12-14; Stigma Maydis 13-16; Fructus Aurantii Immaturus 11-14; Caulis Lonicerae 13-14; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 11-13; Pericarpium Citri Reticulatae 14-16; Herba Glechomae 15-18; Fructus Toosendan 11-13.
Be more preferably, Radix Cynanchi Paniculati 15.5; Herba Silybi mariani 13.5; Pollen Typhae 11.5; Oletum Trogopterori 7.5; Semen Cuscutae 13; Stigma Maydis 14.5; Fructus Aurantii Immaturus 12.5; Caulis Lonicerae 13.5; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 12; Pericarpium Citri Reticulatae 15; Herba Glechomae 16.5; Fructus Toosendan 12.
The cholagogic and lithagogue agent for the treatment of cholelithiasis, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Pericarpium Citri Reticulatae is cleaned, spray tide, and put in food steamer and to steam after supreme gas 20 minutes, take out spreading for cooling, shave, dry, pulverize, for subsequent use; Fructus Toosendan adds Chinese liquor and mixes thoroughly, puts moderate heat in pot and steams 4-8 hour, is degree to the greatest extent, takes out, dry, pulverize for subsequent use to wine;
(2) Semen Cuscutae and Fructus Aurantii Immaturus are fully dry, wear into fine powder, for subsequent use; Oletum Trogopterori is cleaned, and is cut into small pieces, and puts in pot and fries to black sustainability degree of being with moderate heat, take out, cool, for subsequent use;
(3) by Radix Cynanchi Paniculati, Herba Silybi mariani, Stigma Maydis, Caulis Lonicerae, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi), Pollen Typhae and Herba Glechomae slow fire boiling three times, each clear water respectively adding 6-12 times amount, first time decocts 40-46 minute (preferably first time decocts 43 minutes), second time decocts 32-40 minute (preferably second time decocts 36 minutes), third time decocts 20-30 minute (preferably third time decocts 25 minutes), and merge three decocting liquids, cotton cloth filters, filtrate is concentrated into the extractum that density is about 1.25g/mL, for subsequent use;
(4) by above-mentioned extractum spraying dry, get dry extract powder, and the raw material medicated powder after processing with step (1) and step (2) mixes, and sieves, and with the general ball of honey, makes the pill of Semen Firmianae size, to obtain final product.
The preparation method of the cholagogic and lithagogue pill of above-mentioned treatment cholelithiasis, preferred scheme is, in step (1), moderate heat steams 5-7 hour (preferred moderate heat steams 6 hours).
The preparation method of the cholagogic and lithagogue pill of above-mentioned treatment cholelithiasis, preferred scheme is, respectively adds the clear water (preferably at every turn respectively adding the clear water of 9 times amount) of 8-10 times amount in step (3) at every turn.
The preparation method of the cholagogic and lithagogue pill of above-mentioned treatment cholelithiasis, preferred scheme is, the middle 50-90 mesh sieve excessively of step (4) (preferred 60-80 mesh sieve excessively, mistake 70 mesh sieve be more preferably).
The preparation method of described water preparation is:
(1) Pollen Typhae is cleaned, and puts in medicine pot, and intense fire is fried to sepia, and taking-up is dried, and smashs to pieces for subsequent use; Oletum Trogopterori is cleaned, and puts in pot, and the micro-stir-fry of slow fire for a moment, sprays yellow wine (Oletum Trogopterori: yellow wine=25:3), then fries to micro-dry, and taking-up is dried, and smashs to pieces for subsequent use;
(2) by surplus stock medicine in 70-80 DEG C of dry 10-18 minute (being preferable over 75 DEG C of dryings 14 minutes), then in 42-50 DEG C of dry 45-66 minute (being preferable over 46 DEG C of dryings 55 minutes), be ground into fine powder, for subsequent use;
(3) the raw material medicated powder after step (1) and step (2) process is added the pure water (preferably adding the pure water of 5 times amount) of 4-6 times amount, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 32-46 minute (preferably first time decocts 39 minutes), second time decocts 24-30 minute (preferably second time decocts 27 minutes), merge twice decocting liquid, filter, obtain filtrate;
(4) above-mentioned gained filtrate is concentrated into medicinal liquid than being 1:3, dry heat sterilization, encapsulation, to obtain final product.
The preparation method of described granule is:
(1) Pollen Typhae is cleaned, and puts in medicine pot, and intense fire is fried to sepia, and taking-up is dried, and smashs to pieces for subsequent use; Oletum Trogopterori is cleaned, and puts in pot, and the micro-stir-fry of slow fire for a moment, sprays yellow wine (Oletum Trogopterori: yellow wine=25:3), then fries to micro-dry, and taking-up is dried, and smashs to pieces for subsequent use;
(2) Stigma Maydis is cleaned, and puts in crucible, forges and be popular in smokeless stove fire, pour in vinegar basin shortcake of quenching (Stigma Maydis: vinegar=10:3) into, pull out, dry, smash to pieces, for subsequent use;
(3) surplus stock is placed in air drier, in 55-65 DEG C of hot air drying 20-30 minute (being preferable over 60 DEG C of hot air dryings 25 minutes), taking out, be placed in Chinese medicine grinder and be together ground into fine powder, for subsequent use;
(4) by the fine powder mixing after step (1)-step (3) process; cross 110 mesh sieves; add sucrose fine and sodium cellulosate (raw material medicated powder: sucrose fine: sodium cellulosate=6:1.2:1.1); be placed in granulator and make granule; be distributed into bag according to the metering (preferably according to the metering of 30g/ bag) of 25-35g/ bag, obtain final product.
The preparation method of described tablet is:
(1) various crude drug is taken by formula proportion, dry, wear into fine powder, cross 120 mesh sieves, obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.25-0.35g/ sheet (preferably according to 0.3g/ sheet), make tablet dosage form according to the preparation for processing of tablet.
Scientific formula of the present invention, preparation method is simple, effectively easy to use, safe.In addition, excellent results of the present invention also shows:
1,traditional property of medicine and Chinese medicine modern pharmacology organically combine by the present invention, utilize ingredients synergism, jointly play effect of heat-clearing and toxic substances removing, hepatic cholagogic, antiinflammatory lithodialysis, have cure curative effect significantly to cholelithiasis;
2,medicine of the present invention not only obviously improves the clinical symptoms of patient, alleviates misery, and have short treating period, action effect rapidly and more after effect of not recurring;
3,medicine source of the present invention is easy to get, and medical material is with low cost, has no side effect, and has higher promotional value.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Cynanchi Paniculati: base is former: be root and rhizome or the whole herb with root of asclepiadaceae plant Radix Cynanchi Paniculati.Chemical analysis: herb is containing paeonol about 1%.Finding out again to sarcostin, going acyl Corii Bovis seu Bubali to moor glycoside unit, the first material very similar with removing acyl periplogenin of fine hair milk rattan glycoside and acetic acid, cinnamic acid etc.Root is containing flavonoid glycoside, saccharide, aminoacid, paeonol.Pharmacological action: mouse peritoneal injection Radix Cynanchi Paniculati extracting solution, can show minimizing spontaneous activity, but not extend the length of one's sleep of barbiturates, also have analgesic activity.Nature and flavor: pungent, temperature.Function cures mainly: analgesia, cough-relieving, inducing diuresis to remove edema, promoting blood circulation and detoxication.Treat for stomachache, toothache, rheumatalgia, abdominal pain in menstruation, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria, venom.
Herba Silybi mariani: base is former: be herb and the achene of feverfew Herba Silybi mariani.Chemical analysis: herb contains flavonoid and Fumaric acid; Seed aqueous flies Ji guest, Isosilybin, dehydro-silibinin, silidianin, Silychristin, silibinin polymer and cinnamic acid, myristic acid, palmitic olefinic acid, arachidic acid etc.Nature and flavor: cold in nature, bitter in the mouth.Function cures mainly: herb is used for abscess and erysipelas; Fruit and extract are used for hepatopathy, spleen sick cholelithiasis, jaundice and chronic cough.
Pollen Typhae: base is former: for Typhaceae plant typha angustata, typha angustifolia, common cattail or its belong to the pollen of various plants together.Chemical analysis: the pollen of typha angustata contains the glycoside of isorhamnetin, pentacosane, volatile oil and fatty oil about 10%.Fatty oil is containing free Palmic acid and stearic acid about 30%, and sitosterol about 13%, in addition still containing glyceride, the α-typhasterol of Palmic acid, stearic acid and oleic acid.Pharmacological action: 1. Pollen Typhae decoct, tincture, ether immersion all shows excitation to uterus in vitro and in place; 2. Pollen Tyjphae extract can make isolated rabbit enterokinesia strengthen, but can block by atropine; 3. oral infusion or 5% ethanol immersion can make rabbit clotting time obviously shorten; Pollen Tyjphae extract makes the increase of Rabbit Blood Platelets number, prothrombin time shortens; The external of Pollen Typhae powder has anastalsis to dog arterial hemorrhage; 4. high concentration (1:100) Pollen Typhae decoct can suppress the growth of tulase in vitro, has some curative effect to guinea pig experimental tuberculosis.Nature and flavor: Gan Xin are cool.Gui Jing: enter liver, heart channel.Function cures mainly: cooling blood for hemostasis, activating blood circulation and dissipating blood stasis.Raw with controlling amenorrhea stomachache, postpartum stagnation is had a pain, and falls that to flutter blood vexed, furuncle toxic swelling; Fry black emesis blood, epistaxis, metrorrhagia, rushes down blood, hematuria, dysentery, leukorrhagia; External treatment congenital deformity of the tongue, aphtha, Ting discharging ear, hemorrhage in ear, uncontrolled urination is itched.
Oletum Trogopterori: base is former: be the dry feces of flying squirrel section animal trogopterus xanthipes and flying squirrel etc.Nature and flavor: bitter sweet, temperature.Gui Jing: enter liver, spleen channel.Function cures mainly: life promoting the circulation of blood pain relieving.Control all pains of trusted subordinate's vim and vigour, women's amenorrhea, postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite.Stir-fry is stopped blooding.Control metrorrhagia, menorrhagia, leucorrhea with bloody discharge is without cease.
Semen Cuscutae: source: this product is the dry mature seed of convolvulus cuscuta plant.Nature and flavor: sweet, temperature.Gui Jing: return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Stigma Maydis: base is former: be the zeistic style of grass.Chemical analysis: fatty oily 2.5%, volatile oil 0.12%, tree gelatinoid 3.8%, resin 2.7%, bitterness glucoside 1.15%, Saponin 3.18%, alkaloid are O.05%.Also containing cryptoxanthine, ascorbic acid, pantothenic acid, inositol, vitamin K, sitosterol, stigmasterol, malic acid, citric acid, tartaric acid, oxalic acid etc.Pharmacological action: 1. diuresis; 2. to the effect of blood circulation: anesthetized dog intravenous injection decoct has and shows hypotensive effect; 3. blood glucose effect is reduced; 4. function of gallbladder promoting, anastalsis: nature and flavor: sweet, flat.Gui Jing: kidney; Stomach; Liver; Gallbladder meridian.Function cures mainly: diuresis, expels the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting.Control oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, acute mastitis.
Fructus Aurantii Immaturus: base is former: be rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn. or fragrant round young fruit.Chemical analysis: the peel of Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) and Fructus Citri tangerinae platymiscium all containing volatile oil, and contains flavonoid glycoside etc. more.Pharmacological action: 1. to the effect in uterus: with Fructus Aurantii and the Fructus Aurantii Immaturus decocting liquid of three Different sources (Sichuan, Jiangxi, Hunan), to mice isolated uterine (pregnant and unpregnancy) all in inhibitory action; At body and isolated uterine (pregnant and unpregnancy), excitement is all to rabbit.Also prove to make uterine contraction to rabbit uterus fistula strong, tension force increases, and even occurs tetanic contraction.2. on the impact of intestinal tube: the Fructus Aurantii of three Different sources and Fructus Aurantii Immaturus, be all suppress to the intestine in vitro of mice and rabbit; 3. to the effect of the heart, blood vessel: be in a small amount excited to the in vitro heart of Bufo siccus, suppress in a large number.With Fructus Aurantii decocting liquid or alcohol extract to dog intravenous injection, remarkable boosting can be caused.The Fructus Aurantii of three Different sources and the real decocting liquid of maple, prove there is the effect of light contraction blood vessel with Bufo siccus system vascular irrigation method; To anesthetized dog, there is significantly and rapidly boosting.Nature and flavor: bitter, cold.Gui Jing: enter spleen, stomach warp.Function cures mainly: dispelling the stagnated QI, and loose painful abdominal mass, rushes down expectorant, removing food stagnancy.Control distension and fullness of the chest and abdomen, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.
Caulis Lonicerae: base is former: be the stem and leaf of caprifoliaceae plant Radix Ophiopogonis.Chemical analysis: leaf is containing the flavonoid such as lonicerin and luteolin-7-scillabiose, luteolin.Stem is containing tannin, alkaloid.Pharmacological action: luteolin has spasmolysis to smooth muscle (rabbit residence body small intestinal), but not as good as papaverine; And have mild diuretic (increasing the discharge of sodium chloride) effect.Nature and flavor: sweet, cold.Gui Jing: enter the heart, lung meridian.Function cures mainly: heat clearing away, removing toxic substances, dredging collateral.Control epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.
Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi): base is former: be root or the herb of amaranthaceous plant Amaranthusspinosus L..Chemical analysis: root is containing flavonoid glycoside, aminoacid, organic acid, saccharide.Nature and flavor: sweet, cold.Gui Jing: " east, Fujian book on Chinese herbal medicine ": " enter the heart, kidney two warp." function cures mainly: heat clearing away, dampness removing, removing toxic substances, detumescence.Control dysentery, have blood in stool, edema, leucorrhea, cholelithiasis, scrofula, hemorrhoid, furuncle, laryngalgia, venom.
Pericarpium Citri Reticulatae: base is former: this product is the dry mature skin of rutaceae orange and variety thereof.Character: Pericarpium Citri Reticulatae often shells into several lobe, and base portion is connected, what have is irregular lamellar.Orange red or the rufous of outer surface, has fine wrinkle and recessed point-like grease chamber; Inner surface ivory buff, coarse, attached yellow-white or yellowish-brown grain shape vascular bundle.Nature and flavor: bitter, pungent, temperature.Gui Jing: return lung, spleen channel.Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Cure mainly: for fullness in the epigastrium and chest. lack of appetite and vomiting, cough with copious phlegm.
Herba Glechomae: base is former: be the aerial parts of labiate HUOXUEDAN.Chemical analysis: stem, leaf are containing volatile oil, and main constituent is pinocamphone, menthone, isomenthone, pulegone etc., still containing ursolic acid, succinic acid.Nature and flavor: cold nature, acrid in the mouth, micro-hardship.Gui Jing: return liver, kidney, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, diuresis and expelling stone, dissipating blood stasis for subsidence of swelling.For lithangiuria, liver and bile stone, jaundice due to damp-heat, injury from falling down.
Fructus Toosendan: base is former: be the fruit of canella Fructus Toosendan.Chemical analysis: containing Toosendanin, alkaloid, kaempferol, resin, tannin.Nature and flavor: bitter, cold, poisonous.Gui Jing: enter liver, stomach, small intestine meridian.Function cures mainly: except damp and hot, clearing away liver-fire, pain relieving, parasite killing.Control epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the cholagogic and lithagogue agent for the treatment of cholelithiasis, is prepared from by following bulk drugs, is weight portion (100g/ part): Radix Cynanchi Paniculati 13 parts; Herba Silybi mariani 11 parts; Pollen Typhae 8 parts; Oletum Trogopterori 6 parts; Semen Cuscutae 10 parts; Stigma Maydis 12 parts; Fructus Aurantii Immaturus 9 parts; Caulis Lonicerae 11 parts; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 9 parts; Pericarpium Citri Reticulatae 12 parts; Herba Glechomae 13 parts; Fructus Toosendan 10 parts.
The preparation method of the cholagogic and lithagogue pill for the treatment of cholelithiasis is:
(1) Pericarpium Citri Reticulatae is cleaned, spray tide, and put in food steamer and to steam after supreme gas 20 minutes, take out spreading for cooling, shave, dry, pulverize, for subsequent use; Fructus Toosendan adds Chinese liquor and mixes thoroughly, puts moderate heat in pot and steams 4 hours, is degree to the greatest extent, takes out, dry, pulverize for subsequent use to wine;
(2) Semen Cuscutae and Fructus Aurantii Immaturus are fully dry, wear into fine powder, for subsequent use; Oletum Trogopterori is cleaned, and is cut into small pieces, and puts in pot and fries to black sustainability degree of being with moderate heat, take out, cool, for subsequent use;
(3) by Radix Cynanchi Paniculati, Herba Silybi mariani, Stigma Maydis, Caulis Lonicerae, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi), Pollen Typhae and Herba Glechomae slow fire boiling three times, each clear water respectively adding 6 times amount, first time decocts 40 minutes, second time decocts 32 minutes, third time decocts 20 minutes, merges three decocting liquids, and cotton cloth filters, filtrate is concentrated into the extractum that density is about 1.25g/mL, for subsequent use;
(4) by above-mentioned extractum spraying dry, get dry extract powder, and the raw material medicated powder after processing with step (1) and step (2) mixes, and crosses 50 mesh sieves, with the general ball of honey, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 10-14 ball, and warm water takes, 7 days courses for the treatment of.
embodiment 2the cholagogic and lithagogue agent for the treatment of cholelithiasis, is prepared from by following bulk drugs, is weight portion (60g/ part): Radix Cynanchi Paniculati 18 parts; Herba Silybi mariani 16 parts; Pollen Typhae 15 parts; Oletum Trogopterori 9 parts; Semen Cuscutae 16 parts; Stigma Maydis 17 parts; Fructus Aurantii Immaturus 16 parts; Caulis Lonicerae 16 parts; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 15 parts; Pericarpium Citri Reticulatae 18 parts; Herba Glechomae 20 parts; Fructus Toosendan 14 parts.
The preparation method of the cholagogic and lithagogue water preparation for the treatment of cholelithiasis is:
(1) Pollen Typhae is cleaned, and puts in medicine pot, and intense fire is fried to sepia, and taking-up is dried, and smashs to pieces for subsequent use; Oletum Trogopterori is cleaned, and puts in pot, and the micro-stir-fry of slow fire for a moment, sprays yellow wine (Oletum Trogopterori: yellow wine=25:3), then fries to micro-dry, and taking-up is dried, and smashs to pieces for subsequent use;
(2) by surplus stock medicine in 75 DEG C of dryings 14 minutes, then in 46 DEG C of dryings 55 minutes, be ground into fine powder, for subsequent use;
(3) the raw material medicated powder after step (1) and step (2) process is added the pure water of 5 times amount, intense fire is heated to boil, and turns slow fire boiling twice, and first time decocts 39 minutes, and second time decocts 27 minutes, merges twice decocting liquid, filters, obtains filtrate;
(4) above-mentioned gained filtrate is concentrated into medicinal liquid than being 1:3, dry heat sterilization, encapsulation, to obtain final product.
The instructions of taking of gained water preparation of the present invention is: twice daily, each 80-100mL, warmly takes, 7 days courses for the treatment of.
Model case: Song XX, man, 55 years old, on March 15th, 2010 was to our hospital.Patient's readme: suffer from cholelithiasis 2 years, start to feel have slight upper abdomen to ache, do not take notice of, but As time goes on, pain is more come also violent, in local hospital inspection, learn to suffer from cholelithiasis, row operation rubble, symptom past release, still have part rubble not take out in body, patient determines expectant treatment.Come my institute upon somebody's introduction and check treatment.Check: gastral cavilty is swollen, receive can, sleep poor, red tip of the tongue, thin fur, stringy and rolling pulse.B ultrasonic prompting gallbladder repeatedly rubble, diameter < 0.5cm.
Take the cholagogic and lithagogue water preparation of the present embodiment gained treatment cholelithiasis, instructions of taking: twice daily, each 80-100mL, warmly takes, 7 days courses for the treatment of.After taking two courses for the treatment of, B ultrasonic is observed display calculus and is obviously reduced; After continuing two courses for the treatment of of medication, calculus disappears, and all cards are removed, the recovery from illness of patient's self-induction.Within after drug withdrawal three months, pay a return visit, in order, nothing recurs patient body.
embodiment 3the cholagogic and lithagogue agent for the treatment of cholelithiasis, is prepared from by following bulk drugs, is weight portion (90g/ part): Radix Cynanchi Paniculati 14 parts; Herba Silybi mariani 13 parts; Pollen Typhae 10 parts; Oletum Trogopterori 7 parts; Semen Cuscutae 12 parts; Stigma Maydis 13 parts; Fructus Aurantii Immaturus 11 parts; Caulis Lonicerae 13 parts; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 11 parts; Pericarpium Citri Reticulatae 14 parts; Herba Glechomae 15 parts; Fructus Toosendan 11 parts.
The preparation method of the cholagogic and lithagogue granule for the treatment of cholelithiasis is:
(1) Pollen Typhae is cleaned, and puts in medicine pot, and intense fire is fried to sepia, and taking-up is dried, and smashs to pieces for subsequent use; Oletum Trogopterori is cleaned, and puts in pot, and the micro-stir-fry of slow fire for a moment, sprays yellow wine (Oletum Trogopterori: yellow wine=25:3), then fries to micro-dry, and taking-up is dried, and smashs to pieces for subsequent use;
(2) Stigma Maydis is cleaned, and puts in crucible, forges and be popular in smokeless stove fire, pour in vinegar basin shortcake of quenching (Stigma Maydis: vinegar=10:3) into, pull out, dry, smash to pieces, for subsequent use;
(3) surplus stock is placed in air drier, 60 DEG C of hot air dryings 25 minutes, takes out, be placed in Chinese medicine grinder and be together ground into fine powder, for subsequent use;
(4) by the fine powder mixing after step (1)-step (3) process; cross 110 mesh sieves, add sucrose fine and sodium cellulosate (raw material medicated powder: sucrose fine: sodium cellulosate=6:1.2:1.1), be placed in granulator and make granule; enter bag according to the metering, distributing, packaging of 30g/ bag, to obtain final product.
The instructions of taking of gained granule of the present invention is: every day three times, and each 1 bag, warm water is taken after mixing it with water, 7 days courses for the treatment of.
Model case: warm XX, female, 55 years old, patient came here on the 11st in JIUYUE in 2011 and goes to a doctor.Occur that right rib dull pain is vexed swollen without obvious inducement before patient's readme 1 year half, pain and right back.Find choledocholithiasis at local hospital through ultrasound diagnosis, give medicine and carry out lithagogue treatment, remission after treatment; Before two weeks, symptom recurs, and comes my institute after being introduced and checks treatment.Check: the obvious tenderness of upper abdomen on the right side of patient, without Nausea and vomiting symptom.B ultrasonic prompting has diameter to be the calculus of 0.5-1cm.
Take the cholagogic and lithagogue granule of the present embodiment gained treatment cholelithiasis, instructions of taking is: every day three times, and each 1 bag, warm water is taken after mixing it with water, 7 days courses for the treatment of.After treating a course for the treatment of, patient pain obviously alleviates, and B ultrasonic prompting calculus obviously diminishes; Continue two courses for the treatment of of medication, calculus disappears, and other symptoms all disappear, and patient's self-induction is fully recovered.Pay a return visit after three months, without recurrence.
embodiment 4the cholagogic and lithagogue agent for the treatment of cholelithiasis, is prepared from by following bulk drugs, is weight portion (70g/ part): Radix Cynanchi Paniculati 17 parts; Herba Silybi mariani 14 parts; Pollen Typhae 13 parts; Oletum Trogopterori 8 parts; Semen Cuscutae 14 parts; Stigma Maydis 16 parts; Fructus Aurantii Immaturus 14 parts; Caulis Lonicerae 14 parts; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 13 parts; Pericarpium Citri Reticulatae 16 parts; Herba Glechomae 18 parts; Fructus Toosendan 13 parts.
The preparation method of the cholagogic and lithagogue tablet for the treatment of cholelithiasis is:
(1) various crude drug is taken by formula proportion, dry, wear into fine powder, cross 120 mesh sieves, obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.3g/ sheet, make tablet dosage form according to the preparation for processing of tablet.
The instructions of taking of gained tablet of the present invention is: every day three times, each 4-6 sheet, and warm water takes, 7 days courses for the treatment of.
embodiment 5the cholagogic and lithagogue agent for the treatment of cholelithiasis, is prepared from by following bulk drugs, is weight portion (80g/ part): Radix Cynanchi Paniculati 15.5 parts; Herba Silybi mariani 13.5 parts; Pollen Typhae 11.5 parts; Oletum Trogopterori 7.5 parts; Semen Cuscutae 13 parts; Stigma Maydis 14.5 parts; Fructus Aurantii Immaturus 12.5 parts; Caulis Lonicerae 13.5 parts; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 12 parts; Pericarpium Citri Reticulatae 15 parts; Herba Glechomae 16.5 parts; Fructus Toosendan 12 parts.
The preparation method of the cholagogic and lithagogue pill for the treatment of cholelithiasis is:
(1) Pericarpium Citri Reticulatae is cleaned, spray tide, and put in food steamer and to steam after supreme gas 20 minutes, take out spreading for cooling, shave, dry, pulverize, for subsequent use; Fructus Toosendan adds Chinese liquor and mixes thoroughly, puts moderate heat in pot and steams 6 hours, is degree to the greatest extent, takes out, dry, pulverize for subsequent use to wine;
(2) Semen Cuscutae and Fructus Aurantii Immaturus are fully dry, wear into fine powder, for subsequent use; Oletum Trogopterori is cleaned, and is cut into small pieces, and puts in pot and fries to black sustainability degree of being with moderate heat, take out, cool, for subsequent use;
(3) by Radix Cynanchi Paniculati, Herba Silybi mariani, Stigma Maydis, Caulis Lonicerae, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi), Pollen Typhae and Herba Glechomae slow fire boiling three times, each clear water respectively adding 9 times amount, first time decocts 43 minutes, second time decocts 36 minutes, third time decocts 25 minutes, merges three decocting liquids, and cotton cloth filters, filtrate is concentrated into the extractum that density is about 1.25g/mL, for subsequent use;
(4) by above-mentioned extractum spraying dry, get dry extract powder, and the raw material medicated powder after processing with step (1) and step (2) mixes, and crosses 70 mesh sieves, with the general ball of honey, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 10-14 ball, and warm water takes, 7 days courses for the treatment of.
test example 1the clinical practice of the cholagogic and lithagogue agent (embodiment 5) of gained treatment cholelithiasis of the present invention:
1 data and method
1.1 physical data
Choosing the 320 routine Patients with Cholelithiasis that in May, 2010, in JIUYUE ,-2013 carried out the treatment of my institute is object of study.Wherein male 145 example, women 175 example; Age, 48.5 ± 1.5 years old mean age, all test patient all belonged to voluntary participation in 30-71 year.Patient all meets clinical cholelithiasis diagnostic criteria.
1.2 diagnostic criteria
(1) cholelithiasis causes right upper quadrant of the abdomen pain uncomfortable, shoulder back radiating pain, or has nausea and vomiting; (2) display upper right of having a medical check-up abdominal pressure pain murphy sign is positive; (3) B ultrasonic prompting thickening of capsule wall of gallbladder, cholelithiasis.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random, and two groups of patients, in age, the state of an illness, the course of disease etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein experimental group uses gained of the present invention to treat the cholagogic and lithagogue agent of cholelithiasis, and using method: every day three times, each 10-14 ball, warm water takes, 7 days courses for the treatment of.Matched group uses other drug (as medicines such as liver heat removing choleretic granules, DANNING PIAN and compound recipe money grass particles).Observe three courses for the treatment of of treatment altogether.
1.4 curative effect determinate standard
" the new Chinese medicine guideline of clinical investigations " issued with reference to Ministry of Public Health is evaluated.Cure: epigastric discomfort transference cure, without calculus in B ultrasonic prompting gallbladder.Effective: symptom and sign obviously alleviate, B ultrasonic prompting calculus obviously reduces generally, or calculus diminishes more than 50%; Effective: symptom and sign are alleviated to some extent, B ultrasonic prompting calculus reduces before comparatively treating or diminishes; Invalid: after treatment, sings and symptoms is unchanged, and B ultrasonic prompting calculus is without change.(total effective rate=cure rate+obvious effective rate+effective percentage)
1.5 therapeutic outcome
Result is as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group
Therapeutic effect: experimental group total effective rate is 98.5%, and matched group total effective rate is 76.7%.It can thus be appreciated that experimental group successful is better than matched group.
The present invention by Radix Cynanchi Paniculati, Herba Silybi mariani, Pollen Typhae, Oletum Trogopterori, Semen Cuscutae, Stigma Maydis, Fructus Aurantii Immaturus, Caulis Lonicerae, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi), Pericarpium Citri Reticulatae, Herba Glechomae and Fructus Toosendan totally 12 taste primary raw material medicines be prepared from.Fang Zhong, Radix Cynanchi Paniculati can inducing diuresis to remove edema, promoting blood circulation and detoxication; Herba Silybi mariani extract is used for hepatopathy, spleen sick cholelithiasis, jaundice and chronic cough etc.; Pollen Typhae activating blood circulation and dissipating blood stasis; Semen Cuscutae nourishing the liver and kidney; Stigma Maydis has function of gallbladder promoting, anastalsis; Fructus Aurantii Immaturus is regulated the flow of vital energy, and loose painful abdominal mass, rushes down expectorant, removing food stagnancy; Fructus Toosendan can easing the affected liver to relieve pain; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) heat clearing away, dampness removing, removing toxic substances, detumescence.All medicine compatibilities, bring out the best in each other, and play the merit of heat-clearing and toxic substances removing, calculus dissolving and excreting, depressed liver-energy dispersing and QI regulating altogether.After treating three courses for the treatment of, experimental group total effective rate is 98.5%, evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the cholagogic and lithagogue agent of cholelithiasis, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Cynanchi Paniculati 13-18; Herba Silybi mariani 11-16; Pollen Typhae 8-15; Oletum Trogopterori 6-9; Semen Cuscutae 10-16; Stigma Maydis 12-17; Fructus Aurantii Immaturus 9-16; Caulis Lonicerae 11-16; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 9-15; Pericarpium Citri Reticulatae 12-18; Herba Glechomae 13-20; Fructus Toosendan 10-14.
2. the cholagogic and lithagogue agent for the treatment of cholelithiasis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Cynanchi Paniculati 14-17; Herba Silybi mariani 13-14; Pollen Typhae 10-13; Oletum Trogopterori 7-8; Semen Cuscutae 12-14; Stigma Maydis 13-16; Fructus Aurantii Immaturus 11-14; Caulis Lonicerae 13-14; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 11-13; Pericarpium Citri Reticulatae 14-16; Herba Glechomae 15-18; Fructus Toosendan 11-13.
3. the cholagogic and lithagogue agent for the treatment of cholelithiasis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Cynanchi Paniculati 15.5; Herba Silybi mariani 13.5; Pollen Typhae 11.5; Oletum Trogopterori 7.5; Semen Cuscutae 13; Stigma Maydis 14.5; Fructus Aurantii Immaturus 12.5; Caulis Lonicerae 13.5; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 12; Pericarpium Citri Reticulatae 15; Herba Glechomae 16.5; Fructus Toosendan 12.
4. the cholagogic and lithagogue agent of the treatment cholelithiasis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Pericarpium Citri Reticulatae is cleaned, spray tide, and put in food steamer and to steam after supreme gas 20 minutes, take out spreading for cooling, shave, dry, pulverize, for subsequent use; Fructus Toosendan adds Chinese liquor and mixes thoroughly, puts moderate heat in pot and steams 4-8 hour, is degree to the greatest extent, takes out, dry, pulverize for subsequent use to wine;
(2) Semen Cuscutae and Fructus Aurantii Immaturus are fully dry, wear into fine powder, for subsequent use; Oletum Trogopterori is cleaned, and is cut into small pieces, and puts in pot and fries to black sustainability degree of being with moderate heat, take out, cool, for subsequent use;
(3) by Radix Cynanchi Paniculati, Herba Silybi mariani, Stigma Maydis, Caulis Lonicerae, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi), Pollen Typhae and Herba Glechomae slow fire boiling three times, each clear water respectively adding 6-12 times amount, first time decocts 40-46 minute (preferably first time decocts 43 minutes), second time decocts 32-40 minute (preferably second time decocts 36 minutes), third time decocts 20-30 minute (preferably third time decocts 25 minutes), and merge three decocting liquids, cotton cloth filters, filtrate is concentrated into the extractum that density is about 1.25g/mL, for subsequent use;
(4) by above-mentioned extractum spraying dry, get dry extract powder, and the raw material medicated powder after processing with step (1) and step (2) mixes, and sieves, and with the general ball of honey, makes the pill of Semen Firmianae size, to obtain final product.
5. the preparation method of the cholagogic and lithagogue pill for the treatment of cholelithiasis according to claim 4, is characterized in that, in step (1), moderate heat steams 5-7 hour (preferred moderate heat steams 6 hours).
6. the preparation method of the cholagogic and lithagogue pill for the treatment of cholelithiasis according to claim 4, is characterized in that, respectively adds the clear water (preferably at every turn respectively adding the clear water of 9 times amount) of 8-10 times amount in step (3) at every turn.
7. the preparation method of the cholagogic and lithagogue pill for the treatment of cholelithiasis according to claim 4, is characterized in that, the middle 50-90 mesh sieve excessively of step (4) (preferred 60-80 mesh sieve excessively, mistake 70 mesh sieve be more preferably).
8. the cholagogic and lithagogue agent of the treatment cholelithiasis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable water preparation, preparation method is as follows:
(1) Pollen Typhae is cleaned, and puts in medicine pot, and intense fire is fried to sepia, and taking-up is dried, and smashs to pieces for subsequent use; Oletum Trogopterori is cleaned, and puts in pot, and the micro-stir-fry of slow fire for a moment, sprays yellow wine (Oletum Trogopterori: yellow wine=25:3), then fries to micro-dry, and taking-up is dried, and smashs to pieces for subsequent use;
(2) by surplus stock medicine in 70-80 DEG C of dry 10-18 minute (being preferable over 75 DEG C of dryings 14 minutes), then in 42-50 DEG C of dry 45-66 minute (being preferable over 46 DEG C of dryings 55 minutes), be ground into fine powder, for subsequent use;
(3) the raw material medicated powder after step (1) and step (2) process is added the pure water (preferably adding the pure water of 5 times amount) of 4-6 times amount, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 32-46 minute (preferably first time decocts 39 minutes), second time decocts 24-30 minute (preferably second time decocts 27 minutes), merge twice decocting liquid, filter, obtain filtrate;
(4) above-mentioned gained filtrate is concentrated into medicinal liquid than being 1:3, dry heat sterilization, encapsulation, to obtain final product.
9. the cholagogic and lithagogue agent of the treatment cholelithiasis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable granule, preparation method is as follows:
(1) Pollen Typhae is cleaned, and puts in medicine pot, and intense fire is fried to sepia, and taking-up is dried, and smashs to pieces for subsequent use; Oletum Trogopterori is cleaned, and puts in pot, and the micro-stir-fry of slow fire for a moment, sprays yellow wine (Oletum Trogopterori: yellow wine=25:3), then fries to micro-dry, and taking-up is dried, and smashs to pieces for subsequent use;
(2) Stigma Maydis is cleaned, and puts in crucible, forges and be popular in smokeless stove fire, pour in vinegar basin shortcake of quenching (Stigma Maydis: vinegar=10:3) into, pull out, dry, smash to pieces, for subsequent use;
(3) surplus stock is placed in air drier, in 55-65 DEG C of hot air drying 20-30 minute (being preferable over 60 DEG C of hot air dryings 25 minutes), taking out, be placed in Chinese medicine grinder and be together ground into fine powder, for subsequent use;
(4) by the fine powder mixing after step (1)-step (3) process; cross 110 mesh sieves; add sucrose fine and sodium cellulosate (raw material medicated powder: sucrose fine: sodium cellulosate=6:1.2:1.1); be placed in granulator and make granule; be distributed into bag according to the metering (preferably according to the metering of 30g/ bag) of 25-35g/ bag, obtain final product.
10. the cholagogic and lithagogue agent of the treatment cholelithiasis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) various crude drug is taken by formula proportion, dry, wear into fine powder, cross 120 mesh sieves, obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.25-0.35g/ sheet (preferably according to 0.3g/ sheet), make tablet dosage form according to the preparation for processing of tablet.
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