CN104758827B - A kind of composition of medicine for being used to treat acute viral hepatitis - Google Patents

Abstract

The invention discloses a combined medicine for treating acute viral hepatitis, which comprises the following raw materials in parts by weight: 0.01-0.02 parts of adefovir, 15-20 parts of rhubarb, 15-20 parts of licorice, and 15-20 parts of forsythia 20 parts, 15‑20 parts of Atractylodes macrocephala, 15‑20 parts of Desmodium, 15‑20 parts of Banzhilian, 15‑20 parts of Curcuma, 15‑20 parts of raspberry, 15‑20 parts of corn silk. The preparation method of the combined medicine is as follows: firstly, the raw medicinal material is extracted with 10 times the weight of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and the ethanol is recovered under reduced pressure, and then further concentrated to a thick paste , vacuum or microwave drying to obtain a dry extract; then add 8 times the weight of water to the dregs to decoct and extract twice, each time for 1.5 to 2 hours, filter, combine the water extracts, concentrate under reduced pressure to a thick paste, vacuum or Microwave drying to obtain dry extracts; combine the obtained extracts, crush them, add adefovir, and then add starch or dextrin to mix evenly, make tablets, granules or capsules, and pack them separately.

Description

A combination drug for the treatment of acute viral hepatitis

technical field

The invention relates to a combined medicine, in particular to a combined medicine for treating acute viral hepatitis.

Background technique

Acute viral hepatitis refers to a wide range of liver inflammatory diseases caused by specific hepatotropic viruses. The incubation period is between 15 and 45 days, with an average of 25 days, and the total course of disease is 2 to 4 months. There are five types of hepatitis A, B, C, D, and E, and A and E are acute hepatitis with a short incubation period. The main symptoms of viral hepatitis are fatigue, loss of appetite, and abnormal liver function. Some patients may have fever and jaundice. Severe hepatitis is dangerous and has a high mortality rate. The main causes of death were hepatic coma, liver failure, electrolyte disturbance and secondary infection. There is no cross-immunity between various types of hepatitis, and they can be infected simultaneously or successively, mixed infection or overlapping infection, which aggravates the symptoms. Viral hepatitis A and viral hepatitis E are mainly transmitted by feces. Fever and jaundice are common, with an acute course and rare protracted chronicity.

The current conventional treatment for acute viral hepatitis is: antiviral treatment in the early stage, the main drugs are interferon and lamivudine, etc., and liver-protecting drugs are added in the later stage, combined with treatment. In actual treatment, antiviral drugs have strong side effects and drug resistance, and will also cause damage to the patient's renal function.

Contents of the invention

The object of the present invention is to provide a combination medicine for treating acute viral hepatitis.

According to the pathogenesis and pathogenesis characteristics of acute viral hepatitis, the invention provides a combined drug for the treatment of integrated traditional Chinese and western medicine: low-dose antiviral drug, combined with traditional Chinese medicine, for synergistic treatment.

Among them, adefovir plays a major antiviral role. It is phosphorylated by intracellular kinases to form active diphosphates, which competes to inhibit HBV DNA polymerase, thereby inhibiting virus replication.

Each component effect of Chinese medicine of the present invention is as follows:

Rhubarb: Bitter in taste, cold in nature, returns to the spleen, stomach, large intestine, liver, and pericardium meridian, relieves heat and unblocks the intestines, cools blood and detoxifies, expels blood stasis and stimulates menstrual flow. For excess heat constipation, stagnant abdominal pain, dysentery, jaundice due to damp heat. Modern pharmacological studies have shown that rhubarb alcohol extract can inhibit the replication of viruses and have a direct inactivation effect on HBsAg, and it is proposed that rhubarb has a direct virus-killing effect. Rhubarb anthraquinones can combine with DNA to inhibit the biosynthesis of DNA, RNA and protein, thereby inhibiting the replication of bacteria and viruses. Some researchers believe that rhubarb has the effect of enhancing cellular immunity and inhibiting humoral immunity, can inhibit the excessive activation of monocytes and macrophages, reduce the release of TNF, IL-6, IL-1 and other cytokines, and induce the production of interferon in vivo. Play the role of anti-HBV.

Licorice: sweet, flat. Meridian distribution: Guixin, lung, spleen, stomach meridians. Cure mainly invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and relieving pain, coordinating various medicines. Licorice contains active ingredients such as glycyrrhizic acid, which can prevent liver cell damage by inhibiting complement, thereby protecting the liver. In addition, it can also concentrate in the liver cells to inhibit hepatitis B virus. Licorice has corticosteroid-like anti-inflammatory effects. The anti-inflammatory components are glycyrrhizin and glycyrrhetinic acid, which can restore liver function, reduce ALT activity, and inhibit hepatitis B surface antigen and e antigen. Among them, 18α glycyrrhizic acid diamine salt contained in licorice has strong anti-inflammation, protection of liver cell membrane and rapid enzyme reduction, inhibition of liver cell necrosis, promotion of liver cell regeneration and improvement of liver function.

Forsythia: bitter, cool, enters the heart, liver, and gallbladder meridian, clears away heat, detoxifies, dissipates stagnation, and reduces swelling. Modern pharmacological studies have shown that forsythia can significantly reduce transaminases. Forsythia contains oleanolic acid and ursolic acid. Oleanolic acid has obvious protective effects on acute and chronic liver damage, and can make enlarged mitochondria and expanded The rough endoplasmic reticulum is restored; it can also significantly reduce the ballooning degeneration, necrosis and inflammatory response of hepatocytes in acute and chronic liver injury, and promote the regeneration of liver cells; ursolic acid has the effect of reducing transaminase.

Atractylodes macrocephala: bitter in the mouth, sweet, warm in nature. Return spleen, stomach meridian, invigorate the spleen and replenish qi, dry damp and promote diuresis. Atractylodes macrocephala has the effect of invigorating the spleen and drying dampness, so it can be used for weak spleen and stomach, lack of food, fatigue, spleen deficiency and dampness, abdominal distension and diarrhea. Protective effects.

Desmodium: sweet, slightly bitter, cool in nature. Return liver, gallbladder, kidney, urinary bladder channel. Inducing diuresis to relieve stranguria; heat-clearing and toxic substances removing; dispelling blood stasis and reducing swelling. Indications for liver and gallbladder and urinary calculus; damp-heat jaundice; clearing away heat and diuresis to treat stranguria, dehumidification and jaundice, detoxification; used for damp-heat jaundice. This product can clear heat and dampness again, promote jaundice and reduce jaundice, and is used for damp-heat jaundice.

Scutellaria barbata: spicy, bitter, cold in nature. Heat-clearing and toxic substances removing, removing blood stasis and inducing diuresis. For furuncle swelling, sore throat, tumbling pain, edema, jaundice.

Radix Curcumae: pungent, bitter, cold. Promoting blood circulation to relieve pain, promoting qi circulation and relieving depression, clearing away heart-fire and cooling blood, promoting gallbladder and reducing jaundice. It is used for chest and hypochondrium tingling pain, chest obstruction and heart pain, amenorrhea dysmenorrhea, breast distending pain, febrile coma, epilepsy and madness, blood heat vomiting, jaundice and red urine; modern pharmacological studies have shown that turmeric can improve microcirculation and promote damaged blood circulation. Liver cell regeneration and repair.

Raspberry: Nature and flavor: sweet, sour, warm in nature, returns to the liver, kidney, and bladder meridians, nourishes the kidney, strengthens essence and reduces urination, nourishes the liver and improves eyesight. Modern pharmacological research shows that raspberry has the function of enhancing human immune function.

Corn silk: sweet and neutral in taste, diuretic, swelling, lowering blood pressure, hemostasis, choleretic and other effects. This product is sweet, light and flat, and has the function of diuresis, dampness and swelling, and can make the liver and gallbladder damp-heat come out from urine, promote jaundice and reduce jaundice, and is used to treat damp-heat jaundice.

The purpose of the present invention is achieved through the following technical solutions:

A combination medicine for treating acute viral hepatitis of the present invention is characterized in that its components are composed of the following raw materials in parts by weight: 0.01-0.02 parts of adefovir, 15-20 parts of rhubarb, 15-20 parts of licorice 20 parts, 15-20 parts of forsythia, 15-20 parts of Atractylodes macrocephala, 15-20 parts of money grass, 15-20 parts of Scutellaria barbata, 15-20 parts of turmeric, 15-20 parts of raspberry, 15-20 parts of corn silk share.

The preparation method of medicine described in the present invention comprises the following steps

(1) In parts by weight, the raw Chinese medicinal materials are reflux extracted with 10 times the amount of 80% ethanol, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and after the ethanol is recovered under reduced pressure, it is further concentrated to a thick paste , vacuum or microwave drying to obtain dry extract;

(2) Add 8 times the amount of water to decoct the medicinal residues retained in (1) to extract twice, each time for 1.5 to 2 hours, filter, combine the water extracts, concentrate under reduced pressure to a thick paste, and dry in vacuum or microwave , to obtain dry extract;

(3) Combine the extracts obtained in steps (1) and (2), crush them, add adefovir, then add starch or dextrin and mix evenly, make tablets, granules or capsules, and pack them separately. .

The daily dosage of the combined drug for treating acute viral hepatitis is about 0.008 g and 80 g of the raw medicinal materials.

In the combined medicine of the present invention, in the process of treating acute viral hepatitis with low-dose chemical drug adefovir combined with traditional Chinese medicine, the dosage of adefovir is small, the drug resistance is small, and the damage to the patient's renal function is small. The traditional Chinese medicines rhubarb, forsythia, atractylodes macrocephala, desmodium, and barbatae combined play an antiviral effect, and licorice, turmeric, raspberry, and corn silk play a role in protecting the liver and enhancing immunity.

Detailed ways

The present invention will be further described below in conjunction with specific embodiment:

Example 1

Weigh the following Chinese medicinal materials by weight: 150 grams of rhubarb, 150 grams of licorice, 150 grams of forsythia, 150 grams of Atractylodes macrocephala, 150 grams of money grass, 150 grams of Scutellaria barbata, 150 grams of turmeric, 150 grams of raspberry, and 150 grams of corn silk .

Prepare as follows:

(1) The raw medicinal materials are extracted with 14L of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and after the ethanol is recovered under reduced pressure, it is further concentrated to a thick paste, vacuum or microwave dried, and dried extract;

(2) decocting and extracting the medicinal dregs retained in step (1) with 12 L of water twice, each time for 2 hours, filtering, combining the water extracts, concentrating under reduced pressure to a thick paste, and drying in vacuum to obtain a dry extract;

(3) Combine the extracts obtained in steps (1) and (2), crush them, add 0.1 g of adefovir, add starch to a total weight of 300 g, mix evenly, make granules, and pack them separately.

Example 2

Weigh the following Chinese medicinal materials by weight: 200 grams rhubarb, 200 grams licorice, 200 grams forsythia, 200 grams Atractylodes macrocephala, 200 grams desmodium, 200 grams barbata, 200 grams turmeric, 200 grams raspberry, 200 grams corn silk .

Prepare as follows:

(1) The raw medicinal materials are extracted with 18L of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and after the ethanol is recovered under reduced pressure, it is further concentrated to a thick paste, vacuum or microwave dried, and dried extract;

(2) decocting and extracting the medicinal dregs retained in step (1) with 15 L of water twice, each time for 2 hours, filtering, combining the water extracts, concentrating under reduced pressure to a thick paste, and drying in vacuum to obtain a dry extract;

(3) Combine the extracts obtained in steps (1) and (2), crush them, add 0.2 g of adefovir, add starch to a total weight of 300 g, mix evenly, make granules, and pack them separately.

Example 3

Weigh the following Chinese medicinal materials by weight: 180 grams of rhubarb, 180 grams of licorice, 180 grams of forsythia, 180 grams of Atractylodes macrocephala, 180 grams of money grass, 180 grams of Scutellaria barbata, 180 grams of turmeric, 180 grams of raspberry, 180 grams of corn silk .

Prepare as follows:

(1) The raw medicinal materials are extracted with 16L of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and after the ethanol is recovered under reduced pressure, it is further concentrated to a thick paste, vacuum or microwave dried, and dried extract;

(2) decocting and extracting the medicinal residues retained in step (1) with 13 L of water twice, each time for 2 hours, filtering, combining the water extracts, concentrating under reduced pressure to a thick paste, and vacuum drying to obtain a dry extract;

(3) Combine the extracts obtained in steps (1) and (2), crush them, add 0.16 g of adefovir, add starch to a total weight of 300 g, mix evenly, make granules, and pack them separately.

Claims (2)

1. It is 1. a kind of for treating the composition of medicine of acute viral hepatitis, which is characterized in that the component of the composition of medicine be with Lower raw material medicaments in part by weight composition：0.01-0.02 parts of adefovirdipivoxil, 15-20 parts of rheum officinale, 15-20 parts of Radix Glycyrrhizae, 15-20 parts of Fructus Forsythiae, 15-20 parts of Rhizoma Atractylodis Macrocephalae, 15-20 parts of desmodium, 15-20 parts of Sculellaria barbata, 15-20 parts of Radix Curcumae, 15-20 parts of raspberry, corn stigma 15-20 Part；

   Preparation method includes the following steps：

   (1) by weight, it by raw materials of traditional Chinese medicinal materials, is extracted, extracted 2 hours with 80% alcohol reflux of 10 times of amounts, filtering, the dregs of a decoction Retain, collect ethanol extract, after ethyl alcohol is recovered under reduced pressure, be further concentrated into thick paste, vacuum or microwave drying, obtain dry leaching Cream；

   (2) dregs of a decoction retained in (1) step are added to the water boiling and extraction 2 times of 8 times of amounts, 1.5~2 hours every time, filtering merged water Extract is concentrated under reduced pressure into thick paste, vacuum or microwave drying, obtains dry extract；

   (3) dry extract of gained in (1) and (2) step is merged, crushed, added in adefovirdipivoxil, add starch or dextrin mixes It closes uniformly, tablet, particle or capsule is made, dispenses to obtain the final product.
2. 2. the composition of medicine according to claim 1 for being used to treat acute viral hepatitis, which is characterized in that the combination The component of drug is formed for following raw material medicaments in part by weight：0.01 part of adefovirdipivoxil, 18 parts of rheum officinale, 18 parts of Radix Glycyrrhizae, 18 parts of Fructus Forsythiae, 18 parts of Rhizoma Atractylodis Macrocephalae, 18 parts of desmodium, 18 parts of Sculellaria barbata, 18 parts of Radix Curcumae, 18 parts of raspberry, 18 parts of corn stigma.