CN104743879A - Anti-corrosive bioglass and preparation method thereof - Google Patents
Anti-corrosive bioglass and preparation method thereof Download PDFInfo
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- CN104743879A CN104743879A CN201510145158.2A CN201510145158A CN104743879A CN 104743879 A CN104743879 A CN 104743879A CN 201510145158 A CN201510145158 A CN 201510145158A CN 104743879 A CN104743879 A CN 104743879A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000005312 bioglass Substances 0.000 title abstract 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 230000007797 corrosion Effects 0.000 claims abstract description 23
- 238000005260 corrosion Methods 0.000 claims abstract description 23
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims abstract description 21
- 229910001634 calcium fluoride Inorganic materials 0.000 claims abstract description 21
- 239000003999 initiator Substances 0.000 claims abstract description 20
- CHWRSCGUEQEHOH-UHFFFAOYSA-N potassium oxide Chemical compound [O-2].[K+].[K+] CHWRSCGUEQEHOH-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229910001950 potassium oxide Inorganic materials 0.000 claims abstract description 15
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000292 calcium oxide Substances 0.000 claims abstract description 14
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims abstract description 14
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 14
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 14
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910001948 sodium oxide Inorganic materials 0.000 claims abstract description 14
- 239000011521 glass Substances 0.000 claims abstract description 7
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 7
- 238000010791 quenching Methods 0.000 claims abstract description 7
- 230000000171 quenching effect Effects 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- -1 fluorine ions Chemical class 0.000 claims abstract description 6
- GNTDGMZSJNCJKK-UHFFFAOYSA-N divanadium pentaoxide Chemical compound O=[V](=O)O[V](=O)=O GNTDGMZSJNCJKK-UHFFFAOYSA-N 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 18
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 12
- 229960001866 silicon dioxide Drugs 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 10
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 6
- 238000000465 moulding Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 238000009702 powder compression Methods 0.000 claims description 6
- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 claims description 6
- 238000012216 screening Methods 0.000 claims description 6
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims description 5
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 5
- 239000004160 Ammonium persulphate Substances 0.000 claims description 5
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 5
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 5
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 5
- 235000019395 ammonium persulphate Nutrition 0.000 claims description 5
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 5
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 5
- 239000000194 fatty acid Substances 0.000 claims description 5
- 229930195729 fatty acid Natural products 0.000 claims description 5
- 229960005078 sorbitan sesquioleate Drugs 0.000 claims description 5
- 229960004063 propylene glycol Drugs 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 abstract description 8
- 229910052731 fluorine Inorganic materials 0.000 abstract description 8
- 229910001414 potassium ion Inorganic materials 0.000 abstract description 3
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 4
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 239000000919 ceramic Substances 0.000 abstract 1
- 238000000748 compression moulding Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 7
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 3
- PMUNIMVZCACZBB-UHFFFAOYSA-N 2-hydroxyethylazanium;chloride Chemical compound Cl.NCCO PMUNIMVZCACZBB-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000011797 cavity material Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses an anti-corrosive bioglass and a preparation method thereof. The ceramic comprises the following raw materials in parts by weight: 80-90 parts of sodium oxide, 10-20 parts of calcium oxide, 4-6 parts of silicon dioxide, 7-12 parts of phosphorus pentoxide, 9-10 parts of potassium oxide, 10-20 parts of a surfactant, 10-20 parts of calcium fluoride and 20-30 parts of an initiator. The preparation method comprises the following steps: adding the sodium oxide, the calcium oxide, the silicon dioxide, the phosphorus pentoxide, the potassium oxide, the surfactant, the calcium fluoride and the initiator in a platinum crucible, insulating for 1-2h at 1200-1500 DEG C, quenching and then crushing, and sieving; carrying out compression moulding on glass powder. According to the anti-corrosive bioglass and the preparation method thereof disclosed by the invention, a certain amount of fluorine ions and potassium ions is added in the components, so that the bioactivity of the bioglass can be improved, the degradability thereof can be weakened, and the corrosion resistance can be improved.
Description
Technical field
The present invention relates to biological technical field, particularly relate to a kind of corrosion-resistant bio-vitric and preparation method thereof.
Background technology
Fluorine is one of essential trace element of human life activity, and the fluorine content 2.6g in normal human, is only second to silicon and iron.The fluorine of 90% is distributed in the sclerous tissues such as human skeleton and tooth, is mainly deposited in loose sclerotin with the form of inorganic fluorine.Fluorine has vital role to growing and maintaining bone physiological structure function of whole body bone.After hydroxyl in fluorion substituted hydroxy phosphatic rock, due to the difference of ionic radius between fluorine and hydroxyl and character, thus the lattice of hydroxyapatite is distorted, change its crystallinity and structural stability.In addition, when applying as oral cavity material, the dense surface structure that F-HA (phosphatic rock of fluorion substituted hydroxy) has can reduce surface free energy, reduces the adhesion of bacterium, utilizes F
-bacteriostatic action prevent and treat carious tooth.
The biomaterial corrosion resistance nature that prior art fluorine replaces is not strong, is easily corroded.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, provide a kind of corrosion-resistant bio-vitric and preparation method thereof, degradation property is low, and erosion resistance is strong.
The present invention is by the following technical solutions:
Corrosion-resistant bio-vitric, comprises the raw material of following parts by weight: sodium oxide 80 ~ 90 parts, 10 ~ 20 parts, calcium oxide, silicon-dioxide 4 ~ 6 parts, Vanadium Pentoxide in FLAKES 7 ~ 12 parts, potassium oxide 9 ~ 10 parts, 10 ~ 20 parts, tensio-active agent, 10 ~ 20 parts, Calcium Fluoride (Fluorspan), initiator 20 ~ 30 parts.
As preferably, tensio-active agent is one or more in glyceryl monostearate, sorbitan sesquioleate, propylene glycol fatty acid ester or dioctyl sodium sulfosuccinate.
As preferably, the particle diameter of Calcium Fluoride (Fluorspan) is 100-300nm.
As preferably, initiator is one or more in Diisopropyl azodicarboxylate, ammonium persulphate or benzoyl peroxide.
The preparation method of above-mentioned corrosion-resistant bio-vitric, comprise the following steps: sodium oxide, calcium oxide, silicon-dioxide, Vanadium Pentoxide in FLAKES, potassium oxide, tensio-active agent, Calcium Fluoride (Fluorspan), initiator are added in platinum crucible, in 1200 ~ 1500 DEG C of insulation 1 ~ 2h, pulverize after quenching, screening; By glass powder compression moulding.
As preferably, sieve size is 300 ~ 800 orders.
The present invention adds a certain amount of fluorion and potassium ion in moiety, can improve the biological activity of bio-vitric, weakens its degradation property, improves corrosion resistance nature.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described in detail.
embodiment 1
Corrosion-resistant bio-vitric, comprises the raw material of following parts by weight: sodium oxide 80 parts, 20 parts, calcium oxide, silicon-dioxide 6 parts, Vanadium Pentoxide in FLAKES 12 parts, potassium oxide 10 parts, 20 parts, tensio-active agent, 20 parts, Calcium Fluoride (Fluorspan), initiator 30 parts.
Tensio-active agent is glyceryl monostearate, the sorbitan sesquioleate of mass ratio 1:2.
The particle diameter of Calcium Fluoride (Fluorspan) is 100nm.
Diisopropyl azodicarboxylate, ammonium persulphate that initiator is mass ratio 1:2.
The preparation method of above-mentioned corrosion-resistant bio-vitric, comprise the following steps: sodium oxide, calcium oxide, silicon-dioxide, Vanadium Pentoxide in FLAKES, potassium oxide, tensio-active agent, Calcium Fluoride (Fluorspan), initiator are added in platinum crucible, in 1200 DEG C of insulation 1h, pulverize after quenching, screening; By glass powder compression moulding.
Sieve size is 300 orders.
embodiment 2
Corrosion-resistant bio-vitric, comprises the raw material of following parts by weight: sodium oxide 90 parts, 20 parts, calcium oxide, silicon-dioxide 6 parts, Vanadium Pentoxide in FLAKES 12 parts, potassium oxide 10 parts, 20 parts, tensio-active agent, 20 parts, Calcium Fluoride (Fluorspan), initiator 30 parts.
Tensio-active agent is glyceryl monostearate, sorbitan sesquioleate, propylene glycol fatty acid ester, the dioctyl sodium sulfosuccinate of mass ratio 1:2:1:7.
The particle diameter of Calcium Fluoride (Fluorspan) is 300nm.
Initiator is Diisopropyl azodicarboxylate, the benzoyl peroxide of mass ratio 1:4.
The preparation method of above-mentioned corrosion-resistant bio-vitric, comprise the following steps: sodium oxide, calcium oxide, silicon-dioxide, Vanadium Pentoxide in FLAKES, potassium oxide, tensio-active agent, Calcium Fluoride (Fluorspan), initiator are added in platinum crucible, in 1500 DEG C of insulation 2h, pulverize after quenching, screening; By glass powder compression moulding.
Sieve size is 800 orders.
embodiment 3
Corrosion-resistant bio-vitric, comprises the raw material of following parts by weight: sodium oxide 85 parts, 15 parts, calcium oxide, silicon-dioxide 4.6 parts, Vanadium Pentoxide in FLAKES 10 parts, potassium oxide 9.5 parts, 15 parts, tensio-active agent, 15 parts, Calcium Fluoride (Fluorspan), initiator 25 parts.
Tensio-active agent is glyceryl monostearate, propylene glycol fatty acid ester, the dioctyl sodium sulfosuccinate of mass ratio 3:1:1.
The particle diameter of Calcium Fluoride (Fluorspan) is 200nm.
Initiator is Diisopropyl azodicarboxylate, ammonium persulphate, the benzoyl peroxide of mass ratio 7:1:1.
The preparation method of above-mentioned corrosion-resistant bio-vitric, comprise the following steps: sodium oxide, calcium oxide, silicon-dioxide, Vanadium Pentoxide in FLAKES, potassium oxide, tensio-active agent, Calcium Fluoride (Fluorspan), initiator are added in platinum crucible, in 1300 DEG C of insulation 1.5h, pulverize after quenching, screening; By glass powder compression moulding.
Sieve size is 500 orders.
embodiment 4
Corrosion-resistant bio-vitric, comprises the raw material of following parts by weight: sodium oxide 88 parts, 18 parts, calcium oxide, silicon-dioxide 4.6 parts, Vanadium Pentoxide in FLAKES 11 parts, potassium oxide 10 parts, 11 parts, tensio-active agent, 17 parts, Calcium Fluoride (Fluorspan), initiator 26 parts.
Tensio-active agent is glyceryl monostearate, sorbitan sesquioleate, propylene glycol fatty acid ester, the dioctyl sodium sulfosuccinate of mass ratio 1:4:1:6.
The particle diameter of Calcium Fluoride (Fluorspan) is 220nm.
Initiator is Diisopropyl azodicarboxylate, ammonium persulphate, the benzoyl peroxide of mass ratio 1:3:1.
The preparation method of above-mentioned corrosion-resistant bio-vitric, comprise the following steps: sodium oxide, calcium oxide, silicon-dioxide, Vanadium Pentoxide in FLAKES, potassium oxide, tensio-active agent, Calcium Fluoride (Fluorspan), initiator are added in platinum crucible, in 1300 DEG C of insulation 1.2h, pulverize after quenching, screening; By glass powder compression moulding.
Sieve size is 600 orders.
comparative example 1
Identical with embodiment 1, difference is: do not add potassium oxide and Calcium Fluoride (Fluorspan) in moiety.
performance test: the corrosion-resistant bio-vitric of embodiment 1 ~ 4 and comparative example 1 to be placed on respectively in tri methylol amino methane-hydrochloric acid buffer solution 28 days, to measure the weight that they lose, compare its external degradation performance.
| Comparative example 1 | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| Weight (g) before measuring | 500 | 480 | 494 | 500 | 496 |
| Weight (g) after measuring | 460 | 478 | 493 | 499 | 495 |
| Lose weight (g) | 40 | 2 | 1 | 1 | 1 |
| Rate of weight loss % | 8 | 0.4 | 0.2 | 0.2 | 0.2 |
Invention introduces fluorion and potassium ion, can significantly improve the biological activity of bio-vitric, reduce its degradation property, place 28 days in tri methylol amino methane-hydrochloric acid buffer solution, changes in weight is minimum, and erosion resistance is strong.
Be only wherein several specific embodiments of the application above, but the application is not limited thereto, the changes that any person skilled in the art can think of, all should drops in the protection domain of the application.
Claims (6)
1. corrosion-resistant bio-vitric, it is characterized in that, comprise the raw material of following parts by weight: sodium oxide 80 ~ 90 parts, 10 ~ 20 parts, calcium oxide, silicon-dioxide 4 ~ 6 parts, Vanadium Pentoxide in FLAKES 7 ~ 12 parts, potassium oxide 9 ~ 10 parts, 10 ~ 20 parts, tensio-active agent, 10 ~ 20 parts, Calcium Fluoride (Fluorspan), initiator 20 ~ 30 parts.
2. corrosion-resistant bio-vitric according to claim 1, is characterized in that, tensio-active agent is one or more in glyceryl monostearate, sorbitan sesquioleate, propylene glycol fatty acid ester or dioctyl sodium sulfosuccinate.
3. corrosion-resistant bio-vitric according to claim 1, is characterized in that, the particle diameter of Calcium Fluoride (Fluorspan) is 100-300nm.
4. corrosion-resistant bio-vitric according to claim 1, is characterized in that, initiator is one or more in Diisopropyl azodicarboxylate, ammonium persulphate or benzoyl peroxide.
5. based on the preparation method of corrosion-resistant bio-vitric according to claim 1, it is characterized in that, comprise the following steps: sodium oxide, calcium oxide, silicon-dioxide, Vanadium Pentoxide in FLAKES, potassium oxide, tensio-active agent, Calcium Fluoride (Fluorspan), initiator are added in platinum crucible, in 1200 ~ 1500 DEG C of insulation 1 ~ 2h, pulverize after quenching, screening; By glass powder compression moulding.
6. the preparation method of corrosion-resistant bio-vitric according to claim 5, is characterized in that, sieve size is 300 ~ 800 orders.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510145158.2A CN104743879A (en) | 2015-03-31 | 2015-03-31 | Anti-corrosive bioglass and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510145158.2A CN104743879A (en) | 2015-03-31 | 2015-03-31 | Anti-corrosive bioglass and preparation method thereof |
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| CN104743879A true CN104743879A (en) | 2015-07-01 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1213355A (en) * | 1996-01-29 | 1999-04-07 | 巴尔的摩的马里兰大学 | Bioactive glass compositions and methods of treatment using bioactive glass |
| US6756060B1 (en) * | 1996-09-19 | 2004-06-29 | Usbiomaterials Corp. | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
| CN101407373A (en) * | 2008-11-18 | 2009-04-15 | 湖北顶盛科技发展有限公司 | Strontium-reinforced bioactivity glass, production method there and use in tooth-cleaning products |
-
2015
- 2015-03-31 CN CN201510145158.2A patent/CN104743879A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1213355A (en) * | 1996-01-29 | 1999-04-07 | 巴尔的摩的马里兰大学 | Bioactive glass compositions and methods of treatment using bioactive glass |
| US6756060B1 (en) * | 1996-09-19 | 2004-06-29 | Usbiomaterials Corp. | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
| CN101407373A (en) * | 2008-11-18 | 2009-04-15 | 湖北顶盛科技发展有限公司 | Strontium-reinforced bioactivity glass, production method there and use in tooth-cleaning products |
Non-Patent Citations (1)
| Title |
|---|
| 爱地传递LOVE: "生物玻璃", 《百度文库》 * |
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Application publication date: 20150701 |