CN104739726B - A kind of Chinese medicine toothpaste and preparation method thereof - Google Patents
A kind of Chinese medicine toothpaste and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine toothpaste, contain hydroxypropyl beta cyclodextrin clathrate in the toothpaste, the hydroxypropyl beta cyclodextrin clathrate contains Chinese medical extract and hydroxypropyl beta cyclodextrin, and the mass ratio of the Chinese medical extract and hydroxypropyl beta cyclodextrin is 1:3~7；The Chinese medical extract is made up of the component of following weight/mass percentage composition：Coptis extract 15~35%, phellodendron extract 20~40%, Scutellaria baicalensis extract 15~35%, notoginseng extract 10~30%.Chinese medicine toothpaste of the present invention, containing sufficient concentrations of Chinese medical extract so as to clearing heat and removing internal heat, treat the effect of oral cavity gingivitis, bleeding gums and canker sore, and there is good smell and mouthfeel, stability is higher.
Description
Technical field
The present invention relates to a kind of toothpaste and preparation method thereof, especially a kind of Chinese medicine toothpaste containing Chinese medical extract
And preparation method thereof.
Background technology
The making of Chinese medicinal toothpaste is generally divided into two steps, and first is the extraction and post-production processing of traditional Chinese medicine ingredients；Second is
Active component is added in basicly stable formulation of tooth-paste.
Traditional Traditional Chinese medicine extraction method has infusion process, percolation, decocting method, reflux extraction and continuous circumfluence extraction method
Deng being summarized as follows respectively：
A) infusion process：Herbal powder or fragment are fitted into appropriate container during infusion process, add suitable solvent (such as
Ethanol, dilute alcohol or water), dipping medicinal material is in the method for dissolution wherein composition.This law is relatively simple, but leaching rate is poor, and
It is solvent such as with water, its extract solution is easy to moldy metamorphism, notably adds appropriate preservative.
B) percolation：Percolation is that herbal powder is mounted in percolator, constantly adds novel solvent, it is penetrated medicine
Material, from top to bottom from a kind of leaching method of percolator bottom outflow leachate.Add when solvent infilters medicinal powder dissolved element proportion
When moving down greatly, its position is just replaced in the solution on upper strata or dilute immersion liquid, causes good concentration difference, makes diffusion energy preferably
Carry out, therefore leaching effect is better than infusion process.But coutroi velocity is answered, supplements novel solvent from powder at any time in transient is oozed, is made
Untill active ingredient fully leaches in medicinal material, or it is extremely shallow or ooze 10 of volume equivalent to crude drug weight for gushing liquid when ooze dropping liquid color
Times when, can think substantially to have extracted completely.Often using dilute sepage of collection as another batch of new raw material in a large amount of productions
Solvent uses.
C) decocting method：Decocting method is traditional leaching method that China uses earliest, and container used is generally pottery, silo
Or copper, enamel ware, iron pan should not be used, in case decoction changes colour.Preferably often stirring during straight fire heating, so as not to local medicinal material by
Re Taigao, easily it is charred.
D) reflux extraction：Using organic solvent heating extraction, it need to use and be heated at reflux device, in order to avoid solvent volatilization damage
Lose.During a small amount of operations, reflux condenser can be connected on round-bottomed flask, the built-in medicinal material of bottle is about the 30~50% of capacity, solvent
Dipped medicinal material surface about 1~2cm.It is heated to reflux in a water bath, it is general to keep boiling about 1 hour.Filtering is let cool, then in the dregs of a decoction
Solubilizer, make second and third time and be heated to reflux respectively about half an hour, or untill most active ingredient is put forward substantially.This method extraction efficiency
It is high compared with cold-maceration, it is in a large amount of productions to use continuous extraction more.
E) continuous circumfluence extraction method：Using volatile organic solvent extract Chinese herbal medicine effective ingredientses, no matter small test or
Large-scale production, preferably continuous extraction, and need to be less with quantity of solvent, extract component is also more complete.Often use fat in laboratory
Fat extractor or apparatus,Soxhlet's.Continuous extraction, a few hours are typically needed to extract completely.Extract component heated time compared with
Long, the labile composition of case of thermal instability should not use this method.
After extract has been prepared, most of ways on the market are direct or through appropriate processing (as being spray-dried at present
Be processed into powder, be condensed into medicinal extract, dissolved using suitable solvent etc.) after extract added in formulation of tooth-paste used.
The development process of presently commercially available Chinese medicinal toothpaste is elaborated in terms of two above, it can be seen that active ingredient of Chinese herbs carries
Take and the addition manner of extract all has certain limitation and shortcoming, if desired for by being heated at high temperature extraction for a long time, receiving
Rate is relatively low, the extract stability of extraction is unstable and stability to influenceing target product etc..
Traditional Traditional Chinese medicine extraction method (infusion process, percolation, decocting method, reflux extraction and continuous circumfluence extraction method etc.)
Substantially the problems such as Extracting temperature is high, extraction efficiency is low, Extraction solvent residual and recovery rate is relatively low be present；Obtain corresponding extract
Most of smell of extract has the bad smell such as sour, bitter, puckery afterwards；And due to more containing active component, in formulation of tooth-paste
If the extract that desired addition plays therapeutically effective amount enough can in most cases cause lotion of toothpaste to be formulated unstability, so that cannot
As a effective product, in order to make product formula stability and reduce bad smell, generally, drop can only be passed through
The use of low extract is so as to meeting to be formulated basicly stable and lotion is not had bad mouthfeel substantially.
The content of the invention
There is provided a kind of containing a therapeutically effective amount enough it is an object of the invention to overcome above-mentioned the deficiencies in the prior art part
Chinese medical extract, have good stability, the Chinese medicine toothpaste without bad smell and mouthfeel.
To achieve the above object, the technical scheme taken of the present invention is：A kind of Chinese medicine toothpaste, contain in the toothpaste
Hydroxypropyl-beta-cyclodextrin inclusion, the hydroxypropyl-beta-cyclodextrin inclusion contain Chinese medical extract and hydroxy propyl-Beta-ring paste
Essence, and the Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:3~7；
The Chinese medical extract is made up of the component of following weight/mass percentage composition：Coptis extract 15~35%, golden cypress carry
Take thing 20~40%, Scutellaria baicalensis extract 15~35%, notoginseng extract 10~30%.
Chinese medicine toothpaste of the present invention, by the way that Chinese medical extract is included using hydroxypropyl-β-cyclodextrin, warp
Cross inclusion and obtain mixed extract inclusion compound, due to the good aqueous solubility of hydroxypropyl-β-cyclodextrin so that inclusion compound possesses well
Water solubility, increase solubility of the Chinese medical extract in formulation of tooth-paste so that Chinese medical extract can be with formulation of tooth-paste
Enough concentration is added so as to play corresponding efficient functional；Meanwhile have benefited from the inclusion of hydroxypropyl-β-cyclodextrin, can have
Effect covers the strong bad smell such as bitter, puckery, sweet of the coptis, golden cypress, scutellaria, pseudo-ginseng, substantially improves and contains higher Chinese medical extract
The mouthfeel and smell of toothpaste；Simultaneously as Chinese medical extract is included by hydroxypropyl-β-cyclodextrin, Chinese medicine has effectively been obstructed
Contact of the extract directly with other compositions in formulation of tooth-paste, add the stability of formulation of tooth-paste.
The applicant has found by numerous studies, in the hydroxypropyl-beta-cyclodextrin inclusion, Chinese medical extract and hydroxypropyl
The mass ratio of group-beta-cyclodextrin is 1：When 3~7, hydroxypropyl-β-cyclodextrin can preferably include Chinese medical extract, while quilt
The Chinese medical extract of inclusion dissolution can play corresponding efficient functional preferably in formulation of tooth-paste.Present inventor is based on
Basic Theories of Chinese Medicine, found by numerous studies, the Chinese medical extract is made up of the component of following weight/mass percentage composition：The coptis
When extract 15~35%, phellodendron extract 20~40%, Scutellaria baicalensis extract 15~35%, notoginseng extract 10~30%, and
The Chinese medical extract is added in toothpaste in the form of hydroxypropyl-β-cyclodextrin is included into inclusion compound, gained toothpaste energy
Enough there is the effect of good clearing heat and removing internal heat, treatment oral cavity gingivitis, bleeding gums, canker sore.Meanwhile the present application
People also found, when in the Chinese medical extract, the content of the coptis and phellodendron extract is bigger and the content of the two closer to when, institute
The therapeutic effect that toothpaste is stated to oral cavity gingivitis is better.
Chinese medicine toothpaste of the present invention, by coptis extract, phellodendron extract, Scutellaria baicalensis extract and notoginseng extract
Included with hydroxypropyl-β-cyclodextrin, then hydroxypropyl-beta-cyclodextrin inclusion is added in lotion of toothpaste matrix, rely on tooth
Cream is pharmaceutical carrier, and traditional Chinese medicine ingredients are scattered in the oral cavity, by oral mucosa and sublingual capillary absorbance, is directly entered body
In circulation, reach the purpose of prevention and treatment disease.Toothpaste containing the hydroxypropyl-beta-cyclodextrin inclusion, due to wherein
Containing coptis extract, phellodendron extract, Scutellaria baicalensis extract and notoginseng extract, there is clearing heat and removing internal heat, treatment oral cavity gingivitis
The effect of disease, bleeding gums and canker sore, the wherein coptis, golden cypress, the medicine of scutellaria three share, and play synergy, and enhancing is respective
Clearing heat and removing internal heat, bacteriostat degerming the effect of, so as to play treatment gingivitis, the disease such as canker sore, then be equipped with pseudo-ginseng, play
The effect of dissolving stasis and hemostasis, so as to treat the diseases such as bleeding gums.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the coptis extract uses following methods system
It is standby to obtain：The coptis be crushed into 60 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35~55 DEG C, extracting pressure 25
~35mPa, separator outlet blowing after through cycling extraction and keeping 0.5~2.5h of constant temperature and pressure, obtains coptis extract；
The phellodendron extract is prepared using following methods：Golden cypress be crushed into 40 mesh sieves, be placed in supercritical extract
In kettle, extraction temperature is 35~45 DEG C, and extracting pressure is 25~35mPa, through cycling extraction and keeps 0.5~2.5h of constant temperature and pressure
Separator outlet blowing afterwards, obtain phellodendron extract；
The Scutellaria baicalensis extract is prepared using following methods：Scutellaria be crushed into 40 mesh sieves, be placed in supercritical extract
In kettle, extraction temperature is 35~50 DEG C, and extracting pressure is 25~35mPa, through cycling extraction and keeps 1.5~3.5h of constant temperature and pressure
Separator outlet blowing afterwards, obtain Scutellaria baicalensis extract；
The notoginseng extract is prepared using following methods：Pseudo-ginseng be crushed into 40 mesh sieves, be placed in supercritical extract
In kettle, extraction temperature is 35~50 DEG C, and extracting pressure is 25~35mPa, and 95% ethanol makees entrainer, through cycling extraction and keeps
Separator outlet blowing, obtains notoginseng extract after 1.5~3.5h of constant temperature and pressure.
Present inventor extracts the coptis, golden cypress, scutellaria and pseudo-ginseng respectively using supercritical fluid extraction method, through excessive
Amount experiment respectively obtains respective preferable extracting factor, low temperature to normal temperature, it is shorter without dissolvent residual, extraction time
In the case of to more than four kinds of extracts complete extraction so that the coptis, golden cypress, the effective active thing of scutellaria and pseudo-ginseng are fully protected
Deposit, and the active constituent content of the more traditional extraction of the active ingredient contained in extract is higher.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the Chinese medical extract and hydroxy propyl-Beta-ring
The mass ratio of dextrin is 1:5.Present inventor has found, when the Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin
For 1:When 5, the requirement during inclusion to including temperature and time is relatively low, that is, is easier to realize inclusion.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the Chinese medical extract is by following quality percentage
The component composition of content：Coptis extract 25%, phellodendron extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%.This
Apply for that inventor has found, when the Chinese medical extract, which contains the specific ratio, to be combined, gained toothpaste is to dental
The combined therapy effect of gingival inflammation, canker sore and bleeding gums is best.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the hydroxypropyl-beta-cyclodextrin inclusion is adopted
It is prepared using the following method：
(1) hydroxypropyl-β-cyclodextrin is configured to saturated aqueous solution；
(2) coptis extract, phellodendron extract, Scutellaria baicalensis extract and notoginseng extract are mixed, obtains Chinese medical extract；
(3) Chinese medical extract that step (2) obtains is added in the saturated aqueous solution of step (1) and included, included
Temperature is 35~55 DEG C, is stirred 1~3 hour, is dried after filtering, produces hydroxypropyl-beta-cyclodextrin inclusion.
In step (1) described above, hydroxypropyl-β-cyclodextrin is configured to saturated aqueous solution, during operation, it is only necessary in water
Middle to add excessive hydroxypropyl-β-cyclodextrin, then filtering can obtain hydroxypropyl-β-cyclodextrin saturated aqueous solution.
To improve the recovery rate of hydroxypropyl-beta-cyclodextrin inclusion, it is preferable that in the step (3), after inclusion, first will
Inclusion solution is positioned over -8 DEG C to 4 DEG C refrigerations and places a night so that the inclusion compound of generation is almost entirely separated, Ran Houzai
Filtration drying, obtain hydroxypropyl-beta-cyclodextrin inclusion.
Present inventor is included simultaneously using hydroxypropyl-β-cyclodextrin to four kinds of Chinese medical extracts, and through excessive
Experimental study is measured, draws optimal clathrate process, it is possible to increase the yield of inclusion compound, and also four kinds of Chinese medical extracts are after inclusion
It is then added in formulation of tooth-paste, can be very good to play solubility of the increase Chinese medical extract in formulation of tooth-paste so that four kinds
Chinese medical extract has enough concentration, so as to play corresponding efficient functional, and has covered the bad smell of Chinese medical extract
And the mouthfeel and smell of high extract toothpaste are substantially improved, and add the stability of formulation of tooth-paste.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the inclusion temperature in the step (3) is 45
DEG C, mixing time is 2 hours.When the inclusion temperature is 45 DEG C, and mixing time is 2 hours, on this condition, in described
Medicament extract can be included preferably by hydroxypropyl-β-cyclodextrin.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the hydroxypropyl-beta-cyclodextrin inclusion exists
Weight content in toothpaste is 0.1~10%.The hydroxypropyl-β-cyclodextrin that weight content is 0.1~10% is added in toothpaste
Inclusion compound, on the premise of formulation of tooth-paste stability is ensured, the Chinese medical extract in the formulation of tooth-paste is enabled to contain foot
Enough concentration, so as to play the effect of corresponding, gained toothpaste has good clearing heat and removing internal heat, treatment oral cavity gingivitis, gum
The effect of bleeding, canker sore.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the toothpaste also containing NMF, adhesive,
Foaming agent, rubbing agent, saccharin sodium, essence and deionized water, the parts by weight of each component contained in every 100 parts of toothpaste
For：18~57 parts of NMF, 0.8~4 part of adhesive, 1.5~5.5 parts of foaming agent, 12~60 parts of rubbing agent, saccharin sodium 0.1~
0.3 part, 0.1~10 part of hydroxypropyl-beta-cyclodextrin inclusion, 0.8~2 part of essence, surplus be deionized water.
As the more preferably embodiment of Chinese medicine toothpaste of the present invention, contain in every 100 parts of toothpaste each
The parts by weight of component are：30~40 parts of NMF, 0.8~2 part of adhesive, 2~5 parts of foaming agent, 26~35 parts of rubbing agent, sugar
Smart 0.2 part of sodium, 0.8~5 part of hydroxypropyl-beta-cyclodextrin inclusion, 1~1.5 part of essence, surplus are deionized water.Work as the present invention
When the Chinese medicine toothpaste contains the composition of content as described above, the Chinese medicine toothpaste have preferable clearing heat and removing internal heat,
The effect for the treatment of oral cavity gingivitis, bleeding gums and canker sore.
As the most preferred embodiment of Chinese medicine toothpaste of the present invention, contain in every 100 parts of toothpaste each
The parts by weight of component are：38 parts of NMF, 1 part of adhesive, 2.5 parts of foaming agent, 28 parts of rubbing agent, 0.2 part of saccharin sodium, hydroxypropyl
1.2 parts of group-beta-cyclodextrin inclusion compound, 1.2 parts of essence, surplus are deionized water.When Chinese medicine toothpaste of the present invention contains
When the composition of content as described above combines, the Chinese medicine toothpaste has best clearing heat and removing internal heat, treatment oral cavity gum
The effect of inflammation, bleeding gums and canker sore.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the NMF be sorbierite, polyethylene glycol-
8th, at least one of glycerine；Described adhesive is at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is
At least one of lauryl sodium sulfate, sodium lauroyl sarcosine；The rubbing agent is calcium carbonate, in silica at least
It is a kind of；The essence is food-grade essence.
As the preferred embodiment of Chinese medicine toothpaste of the present invention, the toothpaste prepare with the following method and
Into：
(1) by NMF, adhesive, foaming agent, rubbing agent, saccharin sodium and deionized water mix, keep vacuum-
0.09Mpa~-0.096Mpa, stir；
(2) essence and hydroxypropyl-beta-cyclodextrin inclusion are added, keeps vacuum to stir in -0.09Mpa~-0.096Mpa
Mix uniformly, produce Chinese medicine toothpaste.
In the preparation process of toothpaste described above, the visual toothpaste specific formula of step (1) and select suitable mixing time,
Such as 20~50 minutes；The step (2) also can select suitable mixing time according to toothpaste specific formula, such as 10~50
Minute.Toothpaste of the present invention is prepared using a step cream method, and gained lotion has preferable stability.
Chinese medicine toothpaste of the present invention, Chinese medical extract use suitable hydroxypropyl-β-cyclodextrin inclusion technique, increase
The big solubility of coptis extract, phellodendron extract, Scutellaria baicalensis extract and notoginseng extract in formulation of tooth-paste so that four kinds
Chinese medical extract has enough concentration to play the effect of corresponding in toothpaste.And four kinds of Chinese medical extracts pass through hydroxypropyl
After the inclusion of group-beta-cyclodextrin, coptis extract, phellodendron extract, the bitterness of Scutellaria baicalensis extract and pseudo-ginseng are fully covered and have carried
Take the bad smells such as the bitter sweet of thing, substantially improve the mouthfeel of the toothpaste of high content Chinese medical extract, meanwhile, by hydroxypropyl-
After beta-cyclodextrin inclusion compound, enhance containing high content coptis extract, phellodendron extract, Scutellaria baicalensis extract and notoginseng extract
The stability of formulation of tooth-paste.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:3；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 20%, phellodendron extract 40%, Scutellaria baicalensis extract 20%, notoginseng extract 20%.
Described in the present embodiment in hydroxypropyl-beta-cyclodextrin inclusion, the coptis extract is prepared using following methods
Obtain：The coptis be crushed into 60 mesh sieves, be placed in supercritical extraction reactor, extraction temperature be 35~55 DEG C, extracting pressure be 25~
35mPa, separator outlet blowing after through cycling extraction and keeping 0.5~2.5h of constant temperature and pressure, obtains coptis extract；
The phellodendron extract is prepared using following methods：Golden cypress be crushed into 40 mesh sieves, be placed in supercritical extract
In kettle, extraction temperature is 35~45 DEG C, and extracting pressure is 25~35mPa, through cycling extraction and keeps 0.5~2.5h of constant temperature and pressure
Separator outlet blowing afterwards, obtain phellodendron extract；
The Scutellaria baicalensis extract is prepared using following methods：Scutellaria be crushed into 40 mesh sieves, be placed in supercritical extract
In kettle, extraction temperature is 35~50 DEG C, and extracting pressure is 25~35mPa, through cycling extraction and keeps 1.5~3.5h of constant temperature and pressure
Separator outlet blowing afterwards, obtain Scutellaria baicalensis extract；
The notoginseng extract is prepared using following methods：Pseudo-ginseng be crushed into 40 mesh sieves, be placed in supercritical extract
In kettle, extraction temperature is 35~50 DEG C, and extracting pressure is 25~35mPa, and 95% ethanol makees entrainer, through cycling extraction and keeps
Separator outlet blowing, obtains notoginseng extract after 1.5~3.5h of constant temperature and pressure.
Hydroxypropyl-beta-cyclodextrin inclusion is prepared using following methods described in the present embodiment：
(1) hydroxypropyl-β-cyclodextrin is configured to saturated aqueous solution：Excessive hydroxypropyl-β-cyclodextrin is added in water,
Then filtering can obtain hydroxypropyl-β-cyclodextrin saturated aqueous solution；
(2) coptis extract, phellodendron extract, Scutellaria baicalensis extract and notoginseng extract are mixed, obtains Chinese medical extract；
(3) Chinese medical extract that step (2) obtains is added in the saturated aqueous solution of step (1) and included, included
Temperature is 35~55 DEG C, is stirred 1~3 hour, and inclusion solution is positioned over into -8 DEG C to 4 DEG C refrigerations places a night so that generation
Inclusion compound is almost entirely separated, then filtration drying, produces hydroxypropyl-beta-cyclodextrin inclusion.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
Chinese medicine toothpaste is prepared using following methods described in the present embodiment：
(1) by NMF, adhesive, foaming agent, rubbing agent, saccharin sodium and deionized water mix, keep vacuum-
0.09Mpa~-0.096Mpa, stir 20~50 minutes；
(2) essence and hydroxypropyl-beta-cyclodextrin inclusion are added, keeps vacuum to stir in -0.09Mpa~-0.096Mpa
Mix 10~50 minutes, produce Chinese medicine toothpaste.
Embodiment 2
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:4；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 20%, phellodendron extract 30%, Scutellaria baicalensis extract 30%, notoginseng extract 20%.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
In the present embodiment, coptis extract, phellodendron extract in the hydroxypropyl-beta-cyclodextrin inclusion, scutellaria carry
Take the preparation method of thing and notoginseng extract, the preparation method of the hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment institute
The preparation method for stating Chinese medicine toothpaste is same as Example 1.
Embodiment 3
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:5；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 25%, phellodendron extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
In the present embodiment, coptis extract, phellodendron extract in the hydroxypropyl-beta-cyclodextrin inclusion, scutellaria carry
Take the preparation method of thing and notoginseng extract, the preparation method of the hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment institute
The preparation method for stating Chinese medicine toothpaste is same as Example 1.
Embodiment 4
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:6；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 30%, phellodendron extract 25%, Scutellaria baicalensis extract 20%, notoginseng extract 25%.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
In the present embodiment, coptis extract, phellodendron extract in the hydroxypropyl-beta-cyclodextrin inclusion, scutellaria carry
Take the preparation method of thing and notoginseng extract, the preparation method of the hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment institute
The preparation method for stating Chinese medicine toothpaste is same as Example 1.
Embodiment 5
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:5；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 25%, phellodendron extract 35%, Scutellaria baicalensis extract 30%, notoginseng extract 10%.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
In the present embodiment, coptis extract, phellodendron extract in the hydroxypropyl-beta-cyclodextrin inclusion, scutellaria carry
Take the preparation method of thing and notoginseng extract, the preparation method of the hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment institute
The preparation method for stating Chinese medicine toothpaste is same as Example 1.
Embodiment 6
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:7；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 35%, phellodendron extract 20%, Scutellaria baicalensis extract 25%, notoginseng extract 20%.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
In the present embodiment, coptis extract, phellodendron extract in the hydroxypropyl-beta-cyclodextrin inclusion, scutellaria carry
Take the preparation method of thing and notoginseng extract, the preparation method of the hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment institute
The preparation method for stating Chinese medicine toothpaste is same as Example 1.
Embodiment 7
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:3；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 15%, phellodendron extract 40%, Scutellaria baicalensis extract 15%, notoginseng extract 30%.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
In the present embodiment, coptis extract, phellodendron extract in the hydroxypropyl-beta-cyclodextrin inclusion, scutellaria carry
Take the preparation method of thing and notoginseng extract, the preparation method of the hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment institute
The preparation method for stating Chinese medicine toothpaste is same as Example 1.
Embodiment 8
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, described in every 100 parts
Contain the component of following parts by weight in toothpaste：
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:4；The Chinese medical extract is by following weight/mass percentage composition
Component composition：Coptis extract 35%, phellodendron extract 15%, Scutellaria baicalensis extract 35%, notoginseng extract 15%.
In the present embodiment, the NMF is at least one of sorbierite, PEG-8, glycerine；Described adhesive
For at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine
At least one of；The rubbing agent is at least one of calcium carbonate, silica；The essence is food-grade essence.
In the present embodiment, coptis extract, phellodendron extract in the hydroxypropyl-beta-cyclodextrin inclusion, scutellaria carry
Take the preparation method of thing and notoginseng extract, the preparation method of the hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment institute
The preparation method for stating Chinese medicine toothpaste is same as Example 1.
Embodiment 9
Chinese medicine toothpaste stability test of the present invention
The Chinese medicine toothpaste taste subjects being prepared using embodiment 1~8, embodiment 1~8 is prepared
Chinese medicine toothpaste is placed in 50 DEG C of baking oven, fuel-displaced water outlet phenomenon, outer whether occurs every the toothpaste of observation in 15 days
See whether consistent either with or without temperature under color change, toothpaste smell and normal temperature.Observation finds that embodiment 1~8 is prepared into for 3 months
Without there is fuel-displaced water outlet phenomenon, appearance color does not change the Chinese medicine toothpaste arrived substantially, toothpaste smell also with normal temperature
It is lower consistent.Illustrate that the Chinese medicine toothpaste that embodiment 1~8 is prepared is basically identical with properties under normal temperature at high temperature,
Totally it is respectively provided with good stability.
Embodiment 10
Chinese medical extract ratio contained by hydroxypropyl-beta-cyclodextrin inclusion is to oral cavity gum in Chinese medicine toothpaste of the present invention
The influence of the therapeutic effect of inflammation, bleeding gums and canker sore
Experiment is divided into control group and experimental group, and experimental group is set to 1~8 group, in the toothpaste that experimental group 1~8 uses, every 100
Contain the component of following parts by weight in part toothpaste：18~57 parts of NMF, 0.8~4 part of adhesive, foaming agent 1.5~5.5
Part, 12~60 parts of rubbing agent, 0.1~0.3 part of saccharin sodium, 0.1~10 part of hydroxypropyl-beta-cyclodextrin inclusion, essence 0.8~2
Part, surplus are deionized water；The hydroxypropyl-beta-cyclodextrin inclusion contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and
The Chinese medical extract and the mass ratio of hydroxypropyl-β-cyclodextrin are 1:3~7.
It is different that the Chinese medical extract contained in the hydroxypropyl-beta-cyclodextrin inclusion is removed in the toothpaste of experimental group 1~8
Outside, remaining component and the content all same of each component.Described in the toothpaste of experimental group 1~8 in hydroxypropyl-beta-cyclodextrin inclusion
The constituent content difference of the Chinese medical extract contained is as follows：
Chinese medical extract in experimental group 1 is made up of the component of following weight/mass percentage composition：Coptis extract 20%, golden cypress
Extract 40%, Scutellaria baicalensis extract 20%, notoginseng extract 20%；
Chinese medical extract in experimental group 2 is made up of the component of following weight/mass percentage composition：Coptis extract 20%, golden cypress
Extract 30%, Scutellaria baicalensis extract 30%, notoginseng extract 20%；
Chinese medical extract in experimental group 3 is made up of the component of following weight/mass percentage composition：Coptis extract 25%, golden cypress
Extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%；
Chinese medical extract in experimental group 4 is made up of the component of following weight/mass percentage composition：Coptis extract 30%, golden cypress
Extract 25%, Scutellaria baicalensis extract 20%, notoginseng extract 25%；
Chinese medical extract in experimental group 5 is made up of the component of following weight/mass percentage composition：Coptis extract 25%, golden cypress
Extract 35%, Scutellaria baicalensis extract 30%, notoginseng extract 10%；
Chinese medical extract in experimental group 6 is made up of the component of following weight/mass percentage composition：Coptis extract 35%, golden cypress
Extract 20%, Scutellaria baicalensis extract 25%, notoginseng extract 20%；
Chinese medical extract in experimental group 7 is made up of the component of following weight/mass percentage composition：Coptis extract 15%, golden cypress
Extract 40%, Scutellaria baicalensis extract 15%, notoginseng extract 30%；
Chinese medical extract in experimental group 8 is made up of the component of following weight/mass percentage composition：Coptis extract 35%, golden cypress
Extract 15%, Scutellaria baicalensis extract 35%, notoginseng extract 15%.
The toothpaste that control group uses is not in addition to the hydroxypropyl-beta-cyclodextrin inclusion in toothpaste of the present invention is contained, without hydroxyl
The amount water consumption of propyl-beta-cyclodextrin inclusion compound is supplied, and remaining composition and content are identical with the present invention.
1st, the therapeutic effect of oral cavity gingivitis is tested
540 patients for suffering from oral cavity gingivitis are randomly selected, are randomly divided into 9 groups, every group of 60 people, 9 groups of patients distinguish
Using experimental group 1~8 and the toothpaste of control group, once in the morning and once at night, adhere to 2 months, then count the situation of every group of patient,
Oral cavity gingivitis take a favorable turn phenomenon to be effective, what oral cavity gingivitis was substantially achieved treatment is effective, statistical result such as table
1：
Table 1
| Group | Number | Effective number | Efficiently individual quantity | Obvious effective rate | It is efficient | Total treatment rate |
| Control group | 60 | 0 | 0 | 0% | 0% | 0% |
| Experimental group 1 | 60 | 36 | 18 | 60.00% | 30.00% | 90.00% |
| Experimental group 2 | 60 | 31 | 19 | 51.67% | 31.67% | 83.33% |
| Experimental group 3 | 60 | 41 | 18 | 68.33% | 30.00% | 98.33% |
| Experimental group 4 | 60 | 34 | 21 | 56.67% | 35.00% | 91.67% |
| Experimental group 5 | 60 | 36 | 20 | 60.00% | 33.33% | 93.33% |
| Experimental group 6 | 60 | 35 | 19 | 58.33% | 31.67% | 90.00% |
| Experimental group 7 | 60 | 34 | 18 | 56.67% | 30.00% | 86.67% |
| Experimental group 8 | 60 | 33 | 17 | 55.00% | 28.33% | 83.33% |
As seen from Table 1, for experimental group compared with control group, experimental group generally has therapeutic effect to oral cavity gingivitis,
And in experimental group, the effect of 3~6 pairs of oral cavity gingivitis of experimental group 1 and experimental group is better than other experimental groups, especially experimental group
3 total treatment rate highest, has best therapeutic effect to oral cavity gingivitis.This also demonstrates the coptis and phellodendron extract
Content is bigger and the content of the two closer to when, the toothpaste is better to the therapeutic effect of oral cavity gingivitis.
2nd, the therapeutic effect of bleeding gums is tested
504 patients for suffering from bleeding gums are randomly selected, are randomly divided into 9 groups, every group of 56 people, 9 groups of patients use respectively
The toothpaste of experimental group 1~8 and control group, once in the morning and once at night, adhere to 2 months, then count the situation of every group of patient, gum
Bleeding take a favorable turn phenomenon to be effective, what bleeding gums were substantially achieved treatment is effective, statistical result such as table 2：
Table 2
| Group | Number | Effective number | Efficiently individual quantity | Obvious effective rate | It is efficient | Total treatment rate |
| Control group | 56 | 0 | 0 | 0% | 0% | 0% |
| Experimental group 1 | 56 | 37 | 11 | 66.07% | 19.64% | 85.71% |
| Experimental group 2 | 56 | 40 | 11 | 71.43% | 19.64% | 91.07% |
| Experimental group 3 | 56 | 40 | 15 | 71.43% | 26.79% | 98.21% |
| Experimental group 4 | 56 | 40 | 12 | 71.43% | 21.43% | 92.86% |
| Experimental group 5 | 56 | 35 | 13 | 62.50% | 23.21% | 85.71% |
| Experimental group 6 | 56 | 39 | 13 | 69.64% | 23.21% | 92.86% |
| Experimental group 7 | 56 | 41 | 10 | 73.21% | 17.86% | 91.07% |
| Experimental group 8 | 56 | 38 | 10 | 67.86% | 17.86% | 85.71% |
As seen from Table 2, for experimental group compared with control group, experimental group generally has therapeutic effect to bleeding gums, and real
Test in group, the effect of 6~7 pairs of bleeding gums of experimental group 2~4 and experimental group is better than other experimental groups, and especially experimental group 3 is total
Treatment rate highest, there is best therapeutic effect to bleeding gums.
3rd, the therapeutic effect of canker sore is tested
585 patients for suffering from canker sore are randomly selected, are randomly divided into 9 groups, every group of 65 people, 9 groups of patients use respectively
The toothpaste of experimental group 1~8 and control group, once in the morning and once at night, adhere to 2 months, then count the situation of every group of patient, oral cavity
Ulcer take a favorable turn phenomenon to be effective, what canker sore was substantially achieved treatment is effective, statistical result such as table 3：
Table 3
| Group | Number | Effective number | Efficiently individual quantity | Obvious effective rate | It is efficient | Total treatment rate |
| Control group | 65 | 0 | 0 | 0% | 0% | 0% |
| Experimental group 1 | 65 | 41 | 14 | 63.08% | 21.54% | 84.62% |
| Experimental group 2 | 65 | 43 | 17 | 66.15% | 26.15% | 92.31% |
| Experimental group 3 | 65 | 42 | 22 | 64.62% | 33.85% | 98.46% |
| Experimental group 4 | 65 | 40 | 16 | 61.54% | 24.62% | 86.15% |
| Experimental group 5 | 65 | 42 | 19 | 64.62% | 29.23% | 93.85% |
| Experimental group 6 | 65 | 40 | 19 | 61.54% | 29.23% | 90.77% |
| Experimental group 7 | 65 | 42 | 13 | 64.62% | 20.00% | 84.62% |
| Experimental group 8 | 65 | 41 | 19 | 63.08% | 29.23% | 92.31% |
As seen from Table 3, for experimental group compared with control group, experimental group generally has therapeutic effect to canker sore, and real
Test in group, experimental group 2~3, experimental group 5~6 and experimental group 8 are better than other experimental groups to the effect of canker sore, especially in fact
Total treatment rate highest of group 3 is tested, there is best therapeutic effect to canker sore.
From above-mentioned table 1~3, when the Chinese medical extract is made up of the component of following weight/mass percentage composition：The coptis carries
When taking thing 25%, phellodendron extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%, the toothpaste is to oral cavity gingivitis
The therapeutic effect of disease, bleeding gums and canker sore is best.
Embodiment 11
Influence experiment of the traditional Chinese medicine extraction species to toothpaste efficiency
This experiment is divided into 14 groups, and the traditional Chinese medicine extraction species in hydroxypropyl-beta-cyclodextrin inclusion are removed in every group of toothpaste
Difference, remaining composition and content all same, it is specially：The parts by weight of each component contained in every 100 parts of toothpaste are：Protect
23~57 parts of humectant, 1~4 part of adhesive, 1.5~5.5 parts of foaming agent, 12~60 parts of rubbing agent, 0.1~0.3 part of saccharin sodium, hydroxyl
0.1~10 part of propyl-beta-cyclodextrin inclusion compound, 0.8~2 part of essence, surplus are deionized water.The preparation method phase of every group of toothpaste
Together, using the preparation method of heretofore described toothpaste.
The traditional Chinese medicine extraction species contained in every group are as shown in table 4：
Table 4
| Group | Coptis extract | Phellodendron extract | Scutellaria baicalensis extract | Notoginseng extract |
| 1st group | It is | It is | It is | It is |
| 2nd group | It is | It is | It is | It is no |
| 3rd group | It is | It is | It is no | It is no |
| 4th group | It is | It is no | It is | It is no |
| 5th group | It is no | It is | It is | It is no |
| 6th group | It is | It is no | It is no | It is no |
| 7th group | It is no | It is | It is no | It is no |
| 8th group | It is no | It is no | It is | It is no |
| 9th group | It is | It is | It is no | It is |
| 10th group | It is | It is no | It is | It is |
| 11st group | It is no | It is | It is | It is |
| 12nd group | It is | It is no | It is no | It is |
| 13rd group | It is no | It is | It is no | It is |
| 14th group | It is no | It is no | It is | It is |
In table 4, "Yes" represents that, containing corresponding Chinese medical extract, "No" is represented without corresponding Chinese medical extract.
In 1st group of hydroxypropyl-beta-cyclodextrin inclusion, the mass ratio of Chinese medical extract and hydroxypropyl-β-cyclodextrin is
1:3~7, and Chinese medical extract is made up of the component of following weight/mass percentage composition：Coptis extract 15~35%, phellodendron extract
20~40%, Scutellaria baicalensis extract 15~35%, notoginseng extract 10~30%.The system of the hydroxypropyl-beta-cyclodextrin inclusion
Preparation Method uses heretofore described method.
It is identical with the 1st group of component content and preparation method in 2nd~14 group, when not containing a certain Chinese medical extract,
Substituted with the water of equivalent.
840 oral cavity gingivitis patients of selection, 840 canker sore patients and 840 are bleeding gums patient respectively, so
14 groups are randomly divided into afterwards, and every group is 60 people, there is 60 oral cavity gingivitis patients, 60 canker sore patients in the 1st group
With 60 bleeding gums patients, the 2nd~14 group of all same.1st~14 group of toothpaste for using the 1st~14 group in the present embodiment respectively
(in the 1st~14 group of toothpaste, except the species of Chinese medical extract in hydroxypropyl-beta-cyclodextrin inclusion is different, remaining all same),
It is daily to be used continuously 3 months sooner or later respectively with once, count the situation of every group of patient, take a favorable turn or what is fully recovered is effective, statistics knot
Fruit is as shown in table 5：
Table 5
| Group | Oral cavity gingivitis efficiently individual quantity | Canker sore efficiently individual quantity | Bleeding gums efficiently individual quantity |
| 1st group | 55 | 54 | 54 |
| 2nd group | 56 | 53 | 0 |
| 3rd group | 12 | 15 | 0 |
| 4th group | 14 | 11 | 0 |
| 5th group | 12 | 13 | 0 |
| 6th group | 9 | 8 | 0 |
| 7th group | 7 | 8 | 0 |
| 8th group | 8 | 9 | 0 |
| 9th group | 15 | 12 | 53 |
| 10th group | 14 | 14 | 55 |
| 11st group | 11 | 13 | 52 |
| 12nd group | 7 | 9 | 53 |
| 13rd group | 10 | 6 | 52 |
| 14th group | 8 | 7 | 54 |
As seen from Table 5, the 1st group containing coptis extract, phellodendron extract and Scutellaria baicalensis extract and the 2nd group simultaneously,
There is preferable therapeutic effect to oral cavity gingivitis and canker sore, and comprise only coptis extract, phellodendron extract and Huang
The 3rd~14 group of any one or two kinds in Cen extract, to the therapeutic effect of oral cavity gingivitis and canker sore significantly
Reduce, during so as to illustrate that the coptis, golden cypress and the medicine of scutellaria three share, synergy can be played, strengthen respective clearing heat and removing internal heat, suppression
The effect of bacterium is degerming, so as to have significant therapeutic effect to oral cavity gingivitis, canker sore.1st group, the 9th~14 group
In toothpaste, due to containing notoginseng extract, there is preferable therapeutic effect to bleeding gums, and in the 2nd~8 group of toothpaste, because
Not contain notoginseng extract, there is no therapeutic effect to bleeding gums, thus can be explained, Chinese medicine toothpaste of the present invention
In, the effect of pseudo-ginseng of addition can play dissolving stasis and hemostasis, so as to have good effect to treatment bleeding gums.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a kind of Chinese medicine toothpaste, it is characterised in that contain hydroxypropyl-beta-cyclodextrin inclusion, the hydroxyl in the toothpaste
Propyl-beta-cyclodextrin inclusion compound contains Chinese medical extract and hydroxypropyl-β-cyclodextrin, and the Chinese medical extract and hydroxypropyl-
The mass ratio of beta-schardinger dextrin is 1:3~7；
The Chinese medical extract is made up of the component of following weight/mass percentage composition：Coptis extract 25%, phellodendron extract 30%,
Scutellaria baicalensis extract 25%, notoginseng extract 20%.
2. Chinese medicine toothpaste as claimed in claim 1, it is characterised in that the coptis extract is prepared using following methods
Obtain：The coptis be crushed into 60 mesh sieves, be placed in supercritical extraction reactor, extraction temperature be 35~55 DEG C, extracting pressure be 25~
35mPa, separator outlet blowing after through cycling extraction and keeping 0.5~2.5h of constant temperature and pressure, obtains coptis extract；
The phellodendron extract is prepared using following methods：Golden cypress be crushed into 40 mesh sieves, be placed in supercritical extraction reactor,
Extraction temperature is 35~45 DEG C, and extracting pressure is 25~35mPa, is divided after through cycling extraction and keeping 0.5~2.5h of constant temperature and pressure
Blowing is exported from device, obtains phellodendron extract；
The Scutellaria baicalensis extract is prepared using following methods：Scutellaria be crushed into 40 mesh sieves, be placed in supercritical extraction reactor,
Extraction temperature is 35~50 DEG C, and extracting pressure is 25~35mPa, is divided after through cycling extraction and keeping 1.5~3.5h of constant temperature and pressure
Blowing is exported from device, obtains Scutellaria baicalensis extract；
The notoginseng extract is prepared using following methods：Pseudo-ginseng be crushed into 40 mesh sieves, be placed in supercritical extraction reactor,
Extraction temperature is 35~50 DEG C, and extracting pressure is 25~35mPa, and 95% ethanol makees entrainer, through cycling extraction and keeps constant temperature
Separator outlet blowing, obtains notoginseng extract after 1.5~3.5h of constant pressure.
3. Chinese medicine toothpaste as claimed in claim 1, it is characterised in that the Chinese medical extract and hydroxy propyl-Beta-ring paste
The mass ratio of essence is 1:5.
4. Chinese medicine toothpaste as claimed in claim 1 or 2, it is characterised in that the hydroxypropyl-beta-cyclodextrin inclusion is adopted
It is prepared using the following method：
(1) hydroxypropyl-β-cyclodextrin is configured to saturated aqueous solution；
(2) coptis extract, phellodendron extract, Scutellaria baicalensis extract and notoginseng extract are mixed, obtains Chinese medical extract；
(3) Chinese medical extract that step (2) obtains is added in the saturated aqueous solution of step (1) and included, include temperature
For 35~55 DEG C, stir 1~3 hour, dried after filtering, produce hydroxypropyl-beta-cyclodextrin inclusion.
5. Chinese medicine toothpaste as claimed in claim 4, it is characterised in that the inclusion temperature in the step (3) is 45 DEG C,
Mixing time is 2 hours.
6. Chinese medicine toothpaste as claimed in claim 1, it is characterised in that the hydroxypropyl-beta-cyclodextrin inclusion is in tooth
Weight content in cream is 0.1~10%.
7. Chinese medicine toothpaste as claimed in claim 6, it is characterised in that the toothpaste is also containing NMF, adhesive, hair
Infusion, rubbing agent, saccharin sodium, essence and deionized water, the parts by weight of each component contained in every 100 parts of toothpaste are：
18~57 parts of NMF, 0.8~4 part of adhesive, 1.5~5.5 parts of foaming agent, 12~60 parts of rubbing agent, saccharin sodium 0.1~0.3
Part, 0.1~10 part of hydroxypropyl-beta-cyclodextrin inclusion, 0.8~2 part of essence, surplus are deionized water.
8. Chinese medicine toothpaste as claimed in claim 7, it is characterised in that the NMF be sorbierite, PEG-8,
At least one of glycerine；Described adhesive is at least one of sodium carboxymethylcellulose, xanthan gum；The foaming agent is ten
At least one of sodium dialkyl sulfate, sodium lauroyl sarcosine；The rubbing agent is at least one in calcium carbonate, silica
Kind；The essence is food-grade essence.
9. Chinese medicine toothpaste as claimed in claim 7 or 8, it is characterised in that the toothpaste prepare with the following method and
Into：
(1) by NMF, adhesive, foaming agent, rubbing agent, saccharin sodium and deionized water mix, keep vacuum-
0.09Mpa~-0.096Mpa, stir；
(2) essence and hydroxypropyl-beta-cyclodextrin inclusion are added, keeps vacuum equal in -0.09Mpa~-0.096Mpa, stirring
It is even, produce Chinese medicine toothpaste.
10. Chinese medicine toothpaste as claimed in claim 7, it is characterised in that each component contained in every 100 parts of toothpaste
Parts by weight be：38 parts of NMF, 1 part of adhesive, 2.5 parts of foaming agent, 28 parts of rubbing agent, 0.2 part of saccharin sodium, hydroxypropyl-
1.2 parts of Benexate Hydrochloride, 1.2 parts of essence, surplus are deionized water.
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| WO2021106901A1 (en) * | 2019-11-29 | 2021-06-03 | ライオン株式会社 | Oral liquid composition |
| CN114469794A (en) * | 2020-10-28 | 2022-05-13 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method thereof |
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| CN1633969A (en) * | 2004-10-28 | 2005-07-06 | 美晨集团股份有限公司 | A kind of Chinese herbal medicine toothpaste |
| CN101278893A (en) * | 2008-05-30 | 2008-10-08 | 美晨集团股份有限公司 | Chinese herbal medicine toothpaste containing Chinese herbal medicine active combination against Helicobacter pylori and method for producing the same |
| CN102755455A (en) * | 2012-08-11 | 2012-10-31 | 杨献华 | Care solution for oral mucosa ulcer |
| CN103494748A (en) * | 2013-10-17 | 2014-01-08 | 林思哲 | Chinese herbal medicine toothpaste |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1633969A (en) * | 2004-10-28 | 2005-07-06 | 美晨集团股份有限公司 | A kind of Chinese herbal medicine toothpaste |
| CN101278893A (en) * | 2008-05-30 | 2008-10-08 | 美晨集团股份有限公司 | Chinese herbal medicine toothpaste containing Chinese herbal medicine active combination against Helicobacter pylori and method for producing the same |
| CN102755455A (en) * | 2012-08-11 | 2012-10-31 | 杨献华 | Care solution for oral mucosa ulcer |
| CN103494748A (en) * | 2013-10-17 | 2014-01-08 | 林思哲 | Chinese herbal medicine toothpaste |
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Inventor after: Xu Tiansheng Inventor after: Li Yiping Inventor after: Gao Yuyun Inventor before: Xu Tiansheng |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
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| TR01 | Transfer of patent right |
Effective date of registration: 20190823 Address after: 510655 First Floor B1 of Baishuitang 1-2, Huangpu Industrial Avenue, Tianhe District, Guangzhou City, Guangdong Province Patentee after: Dr. Kang Daihua Group Co., Ltd. Address before: 510130 48 Shamian South Street, Guangzhou, Guangdong Province Patentee before: Meichen Group Co., Ltd. |