CN104721276A

CN104721276A - Traditional Chinese medicine vinegar for treating hyperlipidemia

Info

Publication number: CN104721276A
Application number: CN201310749795.1A
Authority: CN
Inventors: 曾祥霖; 曾正
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-24
Filing date: 2013-12-24
Publication date: 2015-06-24

Abstract

The invention discloses traditional Chinese medicine vinegar for treating hyperlipidemia. The traditional Chinese medicine vinegar for treating hyperlipidemia is prepared through the steps of taking 5 parts of ginseng, 10 parts of polygonum multiflorum, 5 parts of rhizoma drynariae, 5 parts of cortex acanthopanacis, 5 parts of silybum marianum, 10 parts of honey and 60 parts of table vinegar; selecting, cleaning and draining the five medicinal materials including the ginseng, the polygonum multiflorum, the rhizoma drynariae, the cortex acanthopanacis and the silybum marianum, placing the five medicinal materials into an alcohol leaching tank, adding 70% ethanol to soak in a way that the liquid level is higher than the surfaces of the medicinal materials, stirring for 15 minutes every two days, filtering an alcohol leaching solution after soaking for 7 days, transferring decoction dregs into a multifunctional extracting tank, adding 10 times of 70% ethanol to carry out reflux extraction for 120 minutes, filtering an ethanol solution, mixing the ethanol solution and the alcohol leaching solution, uniformly standing for a night, filtering supernatant liquid, recovering ethanol, and concentrating liquid medicine without alcohol smell for later use; adding 10 times of water into the decoction dregs in the multifunctional extracting tank, boiling at normal pressure for 120 minutes, and filtering the liquid medicine; then, adding 8 times of water to boil for 90 minutes, filtering the liquid medicine, removing dregs, mixing an alcohol extracting solution and water extracting solutions obtained in twice, uniformly mixing, standing for a night, filtering supernatant liquid, and concentrating to form clear paste; and adding the table vinegar to heat, adding the honey to mix uniformly, boiling for 30 minutes, cooling to be lower than 50 DEG C, finely filtering, carrying out split charging and sterilizing.

Description

A kind of Chinese medicine acetum for the treatment of hyperlipemia

1 art

The present invention relates to a kind of Chinese medicine acetum for the treatment of hyperlipemia, be especially suitable for the course of disease and drink in right amount without the hyperlipidemia patient longer-term of other severe disease slowly, there is therapeutical effect.This formula is suitable for preparing acetum, is also suitable for preparing the Chinese medicine preparation such as tablet, capsule, granule, pill simultaneously.Belong to field of traditional Chinese.

2 background technologies

2.1 modern medicines are to the discussion of hyperlipemia

Lipidemia (Lipaemia): namely there is abnormal significant quantities of fat in blood, as cholesterol lipoprotein (Lipoprotein): be namely present in the histone matter in blood plasma and lymph, it combines with fat or other lipids (as cholesterol), plays an important role in the lipid running of blood and lymph.Lipid is not soluted in water, and serum free fatty acid is combined with serum albumin, triacylglycerol, free cholesterol, cholesterol ester and phospholipid then from different apolipoprotein (apolipoprotein; Apo) (hydrophilic) lipoprotein is combined into.Lipoprotein is divided into four kinds: high density lipoprotein (HDL), low density lipoprotein, LDL (LDL), very low density lipoprotein (VLDL) (VLDL) and Chylomicron (CM).Containing certain density above-mentioned various albumen in Healthy Human Serum, under some physiology and pathologic condition, its content, composition and character can change, and abnormal lipoprotein can be had during some disease to occur.As lipid or lipoprotein content too high, or lipoprotein molecule 26S Proteasome Structure and Function change, containing occurring that atherogenicity (AS) acts on, finally cause multiple cardiovascular, blood pressure, blood lipid disorders.

Hyperlipoproteinemia is divided into constitutional (or heritability) and the large class of Secondary cases two, primary hyperlipoproteinemia reason it be unclear that, and secondary hyperlipoproteinaemia is then closely related with Kou cardiopathia (CHD), atherosclerosis (AS).Namely US and European to be grown up hyperlipemia diagnosis and treatment project respectively within 1988, delivering ATP II (NCEP) and EAS.China formulated in 1997 and announces first " dyslipidemia " remedial proposal.

The control of hyperlipoproteinemia: (1) reduces too high serum TC and LDL.C level, to prevent the formation of AS, especially must strictly control suffering from CHD person.(2) adjustment of diet, to various types of hyperlipoproteinemia, first answers adjustment of diet, keeps on a diet, take exercises.(3) Drug therapy: Carboxymethylcellulose salt derivative (fibric acid) or clofibrate derivant; Fenofibrate (Feaofibrate), gemfibrozil (Gemfibrozil.Lopid), tea Zha Beite (Bezafibrate) etc.But these Drug therapys and resultant effect wait to evaluate.

Clearly statement all without " hyperlipemia " in Chinese medical book, modern Chinese medicine research worker relies on modern science and technology progress, the chemical composition of foundation Chinese crude drug is in conjunction with modern pharmacology pharmacodynamics and clinical verification experience, the Chinese medicine that screening has " blood fat reducing " to act on carries out reducing too high serum TC and LDL level to hyperlipemia, to prevent the formation of AS, and reach the object of control.

2.2 list of references

(1) Chen Haozhu chief editor " practical internal medicine ", ISBN7-117-04313X, People's Health Publisher publishes, April in 2002 the 11st edition.

(2) Zhou Wenguan etc. compile " newly organized tcm clinical practice handbook " ISBN7-80022-555-0 Golden Shield publishing house JIUYUE in 1993 the 1st edition.

(3) Lu Zhaolin etc. put school Shennong's Herbal towering Wu Jin etc. and state, clearly. and Sun Xing spreads out volume ISBN7-5381-2560-4 Liaoning medical courses in general technology publishing house August in 1997 the 1st edition.

(4) Niu Zhanbing writes classical Chinese medicine and orders to arrest Huangdi's Internal Classics ISBN7-5375-1518-8/R-297 Hebei Science Press March in 1994 the 1st edition.

(5) clear-Wu Qian etc. compile Golden Mirror of Medicine ISBN7-117-00728-1/R.729 People's Health Publisher April nineteen ninety-five the 2nd edition

(6) She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press January in 1998 the 1st edition.

(7) Xie Zongwan edits " national Chinese herbal medicine compilation " ISBN7-117-02380-5/8.285, People's Health Publisher October in 1996 the 2nd edition.

(8) Ding Zhaomeng chief editor's " herbal medicine efficacy and clinical " ISBN7-5067-1925-8/R.285, China Medical Science Press February in 1999 the 1st edition.

(9) Liu Guojie edits " pharmaceutics " standard book number: 14048-4693, People's Health Publisher.February in 1985 the 2nd edition;

(10) Fan Biting edits " pharmacy of Chinese materia medica " ISBN7-5323-4439-8/R-1178, January in 1997 the 1st edition.

3 summary of the invention

The present invention relates to a kind of Chinese medicine acetum for the treatment of hyperlipemia, the Chinese medicine with blood fat reducing function has screened in system, be dosage form in conjunction with screening and optimizing Traditional Chinese herbal vinegar, for hyperlipemic patients provides it to need longer-term medication blood fat reducing symptom management to be in progress and avoid causing other complicated Chinese medicine acetum as diseases such as diabetes (being called for short " the clear vinegar drink of blood fat "), utilize Chinese medicine be suitable for take good care of health clothing is used and side effect is lighter advantage and the Chinese medicine acetum as " beverage " dosage form taking convenience for a long time.

3.1 reagent combination

Radix Ginseng 5 parts, Radix Polygoni Multiflori 10 parts, Rhizoma Drynariae 5 parts, Cortex Acanthopancis 5 parts, Herba Silybi mariani 5 parts, Mel 10 parts, vinegar 60 parts.Note: the every kind specifically amount of taking should in the 95%-105% of scalar, and if Radix Polygoni Multiflori 10 parts of batch are 100kg, then the actual amount of taking should between 95kg-105kg.

3.2 technical process

Get Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Drynariae, Cortex Acanthopancis, Herba Silybi mariani gomi herbs pick up pick, clean, drench does, put in alcohol leaching tank and add 70% soak with ethanol, make liquid cross object plane, within every 2 days, stir 15min, flood leaching alcohol immersion after 7 days, medicinal residues dislocation multi-function extractor, adds 10 times amount 70% alcohol reflux 120min, leaching alcohol liquid, merge with alcohol immersion, mixing hold over night, leaching supernatant reclaims ethanol, and remaining several medicinal liquid without alcohol taste is for subsequent use; Medicinal residues in multi-function extractor add 10 times of water gaging normal pressures and boil 120min, leaching medicinal liquid; Add 8 times amount water boil 90min again, leaching medicinal liquid, waste, merge alcohol extract liquid and twice aqueous extract, mixing, hold over night, leaching supernatant, is condensed into clear paste; Add vinegar heating, add purified water 2 times amount, add Mel mixing, boil 30min, let cool to less than 50 DEG C, fine straining, subpackage, namely sterilizing obtains the Chinese medicine acetum " the clear vinegar drink of blood fat " for the treatment of hyperlipemia.

3.3 functions cure mainly and usage and dosage

(1) function cures mainly: invigorating QI to consolidate the body surface resistance, grows spleen nourishing the liver, diuresis toxin expelling.For the lipid-lowering therapy of hyperlipemia.

(2) usage and dosage: oral, each serving 100ml, day takes 2-3 time, takes more than 30 days continuously.

3.4 drug efficacy assays

(1) Radix Ginseng: this product is the dry root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey.

Nature and flavor: sweet, micro-hardship are flat.

Function with cure mainly: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat disappears and drinks, prolonged illness weakness with emaciation, and palpitation with fear insomnia, sexual impotence is sombre, heart failure, cardiogenic shock.

Main containing chemical composition: soaping agents: more than the 30 kind of ginsenosides such as Chikusetsusaponin V (ginsenoside Ro), volatile ingredient: Panaxynol (Panaxynol), β-panacene (β-panascnsene), octanal (octanal), capryl alcohol (Octanol), sad (Octanoic acid) etc., organic acid and ester: citric acid (Citric acid), Rhizoma Corydalis (Fumaric acid), oleic acid (Oleic acid), panax acid (panax acid), triglyceride (Tciglycanride) etc., sterol and glycoside thereof: cupreol (β-sitosterol), stigmasterol (Stigmasterol), daucosterol (daucostcrol) etc., polypeptide, protein and enzyme, nitrogen-containing compound, vitamin, lignin, flavonoid, monosaccharide and polysaccharide, maltol, Cu, Zn, more than the ten kind of inorganic elements such as Fe.

Pharmacological action: (1) can be strengthened corticocerebral process of excitation and process of inhibition to central nervous system and be balanced, makes anxiety cause disorderly nervous process to be recovered, hypermnesis, antifatigue effect.(2) Endocrine system can increase the defence capability of body to destructive stimulus, strengthen organism adaptation, activate hypophysis and interrenal system effect, promote gonadal hormone secretion, male spermatozoa in testis number is increased, make female uterus and ovary accelerated development and ovulation, promote that rutting period extends, illustrate that Radix Ginseng all has gonadal hormone and the effect of promoting sexual gland hormone sample to male, female.(3) to immunologic function energy enhancing human body immunity function, prevent and treat leukopenia, improve the content of Healthy Individuals conversion ratio and gamma globulin, thus improve body's immunity.(4) can heart body be regulated to cardiovascular, blood vessel dilating, reduce high blood low, regulate hypotension shock, effect that prevention of arterial is atherosis.(5) can hyperglycemia be reduced to substance metabolism, reduce lipoprotein (blood fat reducing) in blood, promote protein and RNA synthesis, promote the division of medullary cell, make red, leukocyte rising, growth promoting effects.(6) antitumor action, anti-aging effects, antiinflammatory action, antivirus action, radiation resistance etc.

China's Chinese medicine classics Shennong's Herbal: " Radix Ginseng, sweet in the mouth are slightly cold.Vertical tonifying five ZANG-organs, peace spirit, determine soul, spasmolytic is throbbed with fear, except pathogen, improving eyesight, happily, Fructus Alpiniae Oxyphyllae.Clothes of a specified duration are made light of one's life by commiting suicide, and prolong life.One famous person's rank, a Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.).Go out mountain valley.Wei Wu general day: Radix Ginseng, a Rhizoma Panacis Japonici, a SHENCAO, a Sphallerocarpus gracilis, a Herba Wedeliae Wallichii, a famous person is micro-, a beautiful essence." it serves to show that ancients are farsighted already to Radix Ginseng function.

Clinical practice: opinion rescues shock, treatment arrhythmia, treatment coronary heart disease, treatment hypercholesterolemia, treatment anticoagulant, regulates blood pressure, treatment pulmonary heart disease, treatment leukopenia, treatment acute hepatopathy, treatment dyspepsia, treatment renal anemia, treatment tumor, treatment diabetes, therapeutic malfunction etc., more at most for health care.

Note: (1) Chinese Pharmacopoeia version in 2010 first 8 pages.(2) She Jing etc. compile the 1st edition 19-172 page in " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press January in 1998.(3) Xie Zongwan edits " national Chinese herbal medicine compilation " ISBN7-117-02380-5/8.285, People's Health Publisher October in 1996 the 2nd edition.(4) the new medical college in Jiangsu compiles " Chinese medicine voluminous dictionary " ISBN7-5323-0842-1/R-230, Science and Technology of Shanghai publishing house May in 1986 the 1st edition, the 15th printing May in 2003,29-38 page.(5) Ding Zhaomeng chief editor's " herbal medicine efficacy and clinical " ISBN7-5067-1925-8/R.285, China Medical Science Press February in 1999 the 1st edition.(6) clear Sun Xing spreads out a volume Shennong's Herbal ISBN-7-5381-2560-4, Liaoning Science Press, August in 1997 the 1st edition.

(2) Radix Polygoni Multiflori: this product is the dry root of polygonum multiflorum thunb Polygonum multiflorum Thunb., ministry of Health of China is classified as " can be used for the article of health food ".

Nature and flavor with return footpath: bitter, sweet, puckery, temperature; Return liver, the heart, kidney footpath.

Function with cure mainly: detoxify, eliminating carbuncle, loosening bowel to relieve constipation.For the sick carbuncle sore of scrofula, rubella pruritus, dryness of the intestine constipation; Hyperlipemia is demonstrate,proved.

Chemical composition: the various trace elements such as emodin (emodin), chrysophanol (chrysophanol), chrysophanic acid (rhein), chrysophanic acid anthrone (chrysophanol anthrone), tricin (tricin), Quercetin, Fructus Aristolochiae amide, glucose glycoside, stilbene glycoside, cupreol, carotene, gallic acid, Zn, Cu, Si, ovum phosphoric acid, crude fat, nitrogen, starch, tannin, mineral etc., existing clear and definite composition stilbene glycoside is main blood fat reducing composition.

Pharmacological action: energy decreased heart rate, increases coronary flow, cardiotonic; Reduce plasma cholesterol, triglyceride and beta Lipoprotein, improve lipid metabolism, prevents blood fat from increasing and arteriosclerosis; Delaying senility function, delays involution of thymus and atrophy, enhancing immunity.Facilitation is had, the kidney invigorating to epinephrine and adrenocortical hormone; Functions of loosening bowel relieving constipation; There is growth promoting function to grain system CFU-GM, enrich blood; Antitumor action; Improving growth effect, etc.

Clinical practice: treatment hyperlipemia, treatment neurasthenia, treatment psychotic disorder etc.Be the first-selected Chinese medicine for the treatment of hyperlipemia at present.

Note: She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press January in 1998 the 1st edition 2310 pages.

(3) Rhizoma Drynariae: this product is the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynariafortunei (Kze.) J.Sm. or drynaria baronii Diels D.baronii (Christ) Diels.Ministry of Health of China is classified as " can be used for the article of health food ".

Nature and flavor with return footpath: bitter, warm; Return kidney, liver footpath.

Function with cure mainly: the kidney invigorating bone strengthening, continuous hinder pain relieving.For lumbago due to renal deficiency, ear toot deafness, odontoseisis, falls in flutterring and frustrates, injured bone; External treatment class is bald, vitiligo.

Chemical composition: 22(29)-Hopene (diploptene), A Pa-21-alkene (hop-21-cne), (+)-Hopan-22-ol (diplopterol), fernene, bracken alkene; Naringin, flavanone glycoside, D-Glucose, L-rhamnose, starch etc.

Pharmacological action: promote that bone is to the absorption of calcium, control hormone causes osteoporosis, cardiotonic, blood fat reducing and liver protection effect etc.

The active component flavanone glycoside of Rhizoma Drynariae can reduce serum levels of triglyceride and cholesterol; Rhizoma Drynariae polysaccharide hydrochlorate can protect liver and adrenal organelle; the damage of hypercholesterolemia in anti-cell; thus enhancing cell function; anti-hyperlipidemia blood vessel damage short of money; catch into liver, adrenal gland's inner cholesterol metabolic process, thus make to decline without cholesterol in atherosis district aorta wall, liver, adrenal gland, guarantee hyperlipidemia blood fat reducing.

Clinical practice: treatment hyperlipemia, treatment ankylosing spondylitis etc.

Note: She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press January in 1998 the 1st edition 3333 pages.

(4) Cortex Acanthopancis: this product is the dry root bark of Araliaceae acanthopanax gracilistylus Acanthopanax gracilistylus W.W.Smith.Ministry of Health of China is classified as " can be used for the article of health food ".

Nature and flavor: acrid, bitter, warm.

Effect: wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.

Cortex Acanthopancis is mainly containing Radix Et Caulis Acanthopanacis Senticosi glucoside (eleurthexoside B.), ligustrin (syringin), cupreol (β-sitosterol), daucosterol (daucostcrol), tannin, vitamin (A, B), Palmic acid, linolenic acid etc.There is antiinflammatory action, strengthen immunity function, hypotensive activity, hypoglycemic activity, etc.Note: She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press January in 1998 the 1st edition 997 pages.

(5) Herba Silybi mariani: this product is the dry herb of feverfew Herba Silybi mariani Silybam marianum (L.) Caentn..

Nature and flavor: bitter, cool.

Function with cure mainly: heat-clearing and toxic substances removing, protects the liver, function of gallbladder promoting, anti-X-ray.For acute, chronic hepatitis, hepatitis interstitialis chronica, metabolism toxic liver injury, sand Stranguria.

Chemical composition: silymarin (Silrbin), silidianin (Silydianin), Silychristin (Silychristin), silybonol (isosilychristin), dihydroxyflavone alcohol etc.

Pharmacological action: hepatoprotective effect, regulating blood lipid action, alleviates cerebral edema effect, radiation resistance, anti-erythrocyte haemolysis, suppresses diabetes development effect, control Atherosclerosis, enterohepatic circulation effect.Special hepatoprotective successful.

Clinical practice: treatment acute icterohepatitis type hepatitis, chronic hepatitis, treatment hyperlipemia, antituberculotics liver toxicity, treatment hepatitis B, treatment alcoholic hepatitis, treatment liver portal vein anastomosis etc.

Note: She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press January in 1998 the 1st edition 5559 pages.

(6) Mel: this product is Apidae insecticide apis cerana Apis ceyana fabricius, or the honey that apis mellifera Linnaeus Apis mellifera Linnaeus. makes.Ministry of Health of China is classified as " being food and the article of medicine ", food hygienic standard: GB14963-2003.Nature and flavor with return footpath: sweet, flat; Return lung, spleen, large intestine footpath.Function with cure mainly: invigorating middle warmer is moisturized, pain relieving, removing toxic substances.For the empty pain of gastral cavity abdomen, dryness of the lung dry cough, dryness of the intestine constipation; External treatment skin infection is not held back, burn due to hot liquid or fire.Chemical composition: saccharide: glucose (Glucose) 35%, fructose (fructose) 36%, sucrose (Sucrose) 2.6%, maltose (maltose), dextrin etc.; Organic acid: citric acid (citric acid), malic acid (malic acid), succinic acid, formic acid, acetic acid etc.; Enzyme: amylase (dcastase), invertase (transferase), oxidoreductase, peroxidase etc.; Vitamins: vitamin A, B, B2, B6, C, D, K, nicotinic acid, pantothenic acid, biotin, folic acid, acetylcholine etc.; Amino acids: aspartic acid (ASP), glutamic acid (GLU), leucine (LEU), threonine (THR), serine (SER), glycine (GLY), alanine (ALA), valine (VAL), isoleucine (ILE), lysine (LYS) etc.; Still containing protein, natural gum, pigment, waxiness, natural perfume material, the elements such as K, Fe, Ca, Na, Cu, Mn, P.

Pharmacological action: antibacterial action, antifungic action, antivirus action, protozoacide effect, antitumor action, effect for reducing blood fat, negativity cardiac muscle blood vessel dilating hypotensive effect, promotes gastric secretion effect etc.

Clinical practice: treatment hypertension, hyperlipidemia, treatment intestinal obstruction, treatment burn and scald, treatment ulcerate disease skin infection, treatment constipation, treatment Venenum apis and neuro intoxication, anemia, prostate hyperplasia, beauty treatment etc.Note: She Jing etc. edit " Chinese medicine modern study and application " ISBN7-5077-1318-0, and Xueyuan Press January in 1998 the 1st edition the 5120th page waits document.

(7) vinegar: standard GB/T 2719-2003.For the liquid containing acetic acid led to rice, wheat, highgrain or wine, ethanol etc.Another name: Bitters, pure jealous woman, rice vinegar.Main containing higher alcohols, hydroxy butanone, dipropyl acetone, butyl alcohol, acetaldehyde etc., acetic acid content 3-5%; Nature and flavor: bitter, temperature.Return liver, stomach warp.Function: dissipating blood stasis, hemostasis, removing toxic substances, parasite killing.Full nitrogen containing 0.005%-0.2% in vinegar, is equivalent to the protein of 1%, and in full nitrogen, aminoacid is containing 40%-50%, comprises the free amino acid of more than 18 kinds." book on Chinese herbal medicine is looked for the truth ": " rice vinegar, acid is main holds back, therefore book many sections of dissipating blood stasis removing toxic substances, the therapeutic method to keep the adverse QI flowing downwards helps digestion.To vinegar both acid (receipts), cloud can fall apart the swollen person of pain again, loose then to disappear, routed then to fall apart outward, and receipts place falls apart to locate event ear ".TAO Hong-Jing: " jealous woman wine is use, without not entering.Better.With meat and fish dishes bitterness, for exhaling Bitters ".Supplement to the Herbal: vinegar " removing blood stasis dirty ， Chu wei block heavily fortified point is long-pending, helps digestion; kill vicious, broken stagnation of QI, in the heart sour water phlegm retention ", essentials of Matea Medica: " therapeutic method to keep the adverse QI flowing downwards helps digestion for dissipating blood stasis, removing toxic substances; appetizing gas ", and " occupying diet with breath general " " sky stomach, nourishing the liver; strong muscle, warm bone, relieving alcoholic intoxication; help digestion, the therapeutic method to keep the adverse QI flowing downwards exorcises evil spirits, and separates all poison of fish Eriocheir sinensis aquatic animals ".Note: the new medical college in Jiangsu compiles " Chinese medicine voluminous dictionary " ISBN7-5323-0843-X/R231, Science and Technology of Shanghai publishing house, 2600 pages (volume two).

In a word, Radix Ginseng strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, and spermatogenesis is calmed the nerves; Radix Polygoni Multiflori removing toxicity for eliminating carbuncles, loosening bowel to relieve constipation; Rhizoma Drynariae the kidney invigorating bone strengthening, continues and hinders pain relieving; Cortex Acanthopancis wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening; Herba Silybi mariani hepatic cholagogic; Dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm; Mel invigorating middle warmer is moisturized, analgesic antidotal; Under vinegar, vapour helps digestion; Be combined with invigorating QI to consolidate the body surface resistance, grow spleen nourishing the liver, the strong muscle of the kidney invigorating, effect of dampness removing toxin expelling.The pharmaceutical research of 6 taste Chinese medicines all has effect for reducing blood fat, and clinical being all respectively used to treats hyperlipemia, and curative effect certainly.Particularly the active ingredient stilbene glycoside of Radix Polygoni Multiflori is confirmed to have cholesterol, triglyceride and beta Lipoprotein in definite reduction blood plasma by pharmaceutical research, and blood fat reducing function is definite.

3.5 guardian technique

(1) dosage form selection

For the clinical fact that hyperlipidemia patient is mutually close with AS and CHD disease, that is patient can take the medicine for AS and CHD simultaneously, is the mental burden making patient " take medicine too many, once a lot of ", and select the Chinese medicine acetum of beverage formula, long-term prescription, bioavailability is high, and there is no incompatibility (known at present) with other chemicalses, the toxic and side effects of Chinese medicine is low, as acetum beverage, conveniently drink at any time, therefore select acetum to be suitable for the most.

(2) prescription is concise

According to the dialectical treatmert principle of modern Chinese medicine to hyperlipemia, with the medicine strongly invigorating primordial QI of the large benefit of Radix Ginseng in side, vital base and primordial QI consolidating, the first-selected Chinese medicine of Radix Polygoni Multiflori blood fat reducing is monarch drug altogether; Rhizoma Drynariae, Cortex Acanthopancis invigorating the liver and kidney, bone and muscle strengthening are ministerial drug altogether; Herba Silybi mariani hepatic cholagogic is adjuvant drug; Mel invigorating middle warmer is moisturized, analgesic antidotal, and under vinegar, vapour helps digestion for making medicine; Mel is sweet, and flat, invigorating middle warmer is moisturized, analgesic antidotal, the medicine of the above-mentioned bitter cold of scalable, and square property of traditional Chinese is sweet, pungent, bitter, and cold, Wen Liangjun has coordination, harmony.Vinegar is the medicine of " therapeutic method to keep the adverse QI flowing downwards helps digestion ", and mostly fat for hyperlipidemia patient, digestive function is weak, take vinegar as guiding drug, has and to navigate the effect of adding fuel to the flames by means of water, and therefore prescription is undoubtedly best choice and selects.

(3) medical material extracts active ingredients purification techniques

In side of the present invention, as ginsenoside is soluble in ethanol, its cupreol is insoluble in water, in Radix Polygoni Multiflori, emodin is soluble in ethanol and is insoluble in water, silymarin is water-soluble is hardly soluble in ethanol, Rhizoma Drynariae is containing cupreol, 22(29)-Hopene is insoluble in water and is soluble in ethanol, Cortex Acanthopancis glucoside-containing, the materials such as cupreol Yu Shui hard to tolerate, are all soluble in organic solvent and are comparatively insoluble in water.So the extraction of the present invention to Effective Component of Chinese Medicine have employed room temperature alcohol leaching and circumfluence distillation, then produce active ingredient, the impurity such as peaceful filtering silt, phlegmatic temperament by the mode that water boil extracts for 2 times, concentrated refining, with vinegar dilution, add Mel seasoning, last damp and hot autoclaving.As can longer-term storage acetum beverage not with chemical preservative, guarantee safe for drinking.

3.6 beneficial effects of the present invention

(1) find when being health check-up substantially for hyperlipidemia patient, simultaneously can be closely adjoint mutually with complicated serious symptoms such as AS and CHD, need the feature of long-run adjustment diet, Long-term taking medicine, select acetum, in vinegar solution, add the Effective Component of Chinese Medicine that energy blood fat reducing improves symptom, beverage formula dosage form is made by Modern preparations Technology, patient takes as beverage, and bioavailability is high, overcomes again to take medicine the difficult problem of complicated procedures for a long time, taking convenience, effective.

(2) Chinese medicines such as Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Drynariae, Cortex Acanthopancis, Herba Silybi mariani, Mel are selected all to meet the regulation of ministry of Health of China " notice about further specification healthy food material management " dayfile February 28 in 2002 and list among " being food and the article of medicine ", " can be used for the article of health food ", so the present invention is as a kind of Chinese medicinal health-care drink, legitimately to prevent and cure diseases again.

(3) vinegar itself is the health food flavoring agent of a kind of " therapeutic method to keep the adverse QI flowing downwards helps digestion ", again that “ Chu wei block heavily fortified point is long-pending " medicine; " hyperlipemia " how because of be addicted to drink and obesity with AS and CHD disease, with the thing of " therapeutic method to keep the adverse QI flowing downwards helps digestion " be carrier with fat-reducing effect medicine, disease is improved.

In prescription of the present invention, vinegar is standard GB/T 2719-2003 tablet vinegar, and all raw material is national standard, has food safety guarantee.

4 detailed description of the invention

4.1 prescription compositions: Radix Ginseng 5 parts, Radix Polygoni Multiflori 10 parts, Rhizoma Drynariae 5 parts, Cortex Acanthopancis 5 parts, Herba Silybi mariani 5 parts, Mel 10 parts, vinegar 60 parts.

4.2 functions cure mainly: invigorating QI to consolidate the body surface resistance, grow spleen nourishing the liver, diuresis toxin expelling.For the lipid-lowering therapy of hyperlipemia.

4.3 usage and dosages: oral, each serving 100ml, day takes 2-3 time, takes more than 30 days continuously.

4.4 raw material quality standards

(1) Radix Ginseng: Chinese Pharmacopoeia version in 2010 first 8 pages, Ministry of Public Health can be used for the article of health product.

(2) Radix Polygoni Multiflori: Chinese Pharmacopoeia version in 2010 first 164 pages, Ministry of Public Health can be used for the article of health product.

(3) Rhizoma Drynariae: Chinese Pharmacopoeia version in 2010 first 174 pages, Ministry of Public Health can be used for the article of health product.

(4) Cortex Acanthopancis: Chinese Pharmacopoeia version in 2010 first 61 pages, Ministry of Public Health can be used for the article of health product.

(5) Herba Silybi mariani: Chinese Pharmacopoeia version in 2010 first 76 pages, Ministry of Public Health can be used for the article of health product.

(6) Mel: Chinese Pharmacopoeia version in 2010 first 337 pages, Ministry of Public Health is food and the article of medicine.。

(7) vinegar: GB2719-2003 national standard.

4.5 technological procedure

(1) Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Drynariae, Cortex Acanthopancis, Herba Silybi mariani are carried out picking up picking, abandon impurity, rinse with water, drench is done, section;

(2) put in alcohol leaching cylinder by above-mentioned decoction pieces, add 70% soak with ethanol, liquid crosses object plane, covers tightly, and soaks 1 week, within every two days, stirs 1 time, covers tightly;

(3) leaching alcohol leaching liquid, medicinal residues dislocation multi-function extractor, adds 10 times amount 70% ethanol, makes liquid cross object plane, and reduced-pressure backflow extracts 120min, and let cool, leaching ethanol medicinal liquid, merges with alcohol leaching liquid;

(4) by ethanol medicinal liquid hold over night, leaching supernatant, imports in efficient concentration device, concentrating under reduced pressure, collects ethanol (next time applies mechanically), be condensed into clear paste for subsequent use.

(5) multi-function extractor Chinese medicine slag is added 10 times of water gagings again, normal pressure boils carries 120min, leaching medicinal liquid; 2nd 8 times amount that add water, normal pressure boils carries 90min, leaching medicinal liquid, merges secondary filtrate, hold over night, medicinal residues reject;

(6) the above-mentioned medicinal liquid supernatant of leaching, import in efficient concentration device, concentrating under reduced pressure becomes clear paste, for subsequent use;

(7) by ethanol extraction clear paste, the mixing of water extract clear paste, add vinegar, Mel, stir, add 2 times amount purified water, heated and boiled 15min, do not stop to stir, let cool to room temperature, accurate filtration, subpackage;

(8) with moist heat sterilizer 0.1pma115 DEG C of 25min sterilizing, labeling, vanning, to obtain final product.

4.6 specifically implement example

Radix Ginseng 5kg, Radix Polygoni Multiflori 10kg, Rhizoma Drynariae 5kg, Cortex Acanthopancis 5kg, Herba Silybi mariani 5kg, Mel 10kg, vinegar 60kg, implement according under declaration material description of the present invention " 4.5 technological procedure " item, must treat the Chinese medicine acetum of hyperlipemia.

Function cures mainly: invigorating QI to consolidate the body surface resistance, grows spleen nourishing the liver, diuresis toxin expelling.For the lipid-lowering therapy of hyperlipemia.

Usage and dosage: oral, each serving 100ml, day takes 2-3 time, takes more than 30 days continuously.

Claims

1. treat a Chinese medicine acetum for hyperlipemia, it is characterized in that: get Radix Ginseng 5 parts, Radix Polygoni Multiflori 10 parts, Rhizoma Drynariae 5 parts, Cortex Acanthopancis 5 parts, Herba Silybi mariani 5 parts, Mel 10 parts, vinegar 60 parts; Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Drynariae, Cortex Acanthopancis, Herba Silybi mariani gomi herbs are picked up pick, clean, drench does, put in alcohol leaching tank and add 70% soak with ethanol, make liquid cross object plane, within every 2 days, stir 15min, flood leaching alcohol immersion after 7 days, medicinal residues dislocation multi-function extractor, adds 10 times amount 70% alcohol reflux 120min, leaching alcohol liquid, merge with alcohol immersion, mixing hold over night, leaching supernatant reclaims ethanol, and remaining several medicinal liquid without alcohol taste is for subsequent use; Medicinal residues in multi-function extractor add 10 times of water gaging normal pressures and boil 120min, leaching medicinal liquid; Add 8 times amount water boil 90min again, leaching medicinal liquid, waste, merge alcohol extract liquid and twice aqueous extract, mixing, hold over night, leaching supernatant, is condensed into clear paste; Add vinegar heating, add Mel mixing, boil 30min, let cool to less than 50 DEG C, fine straining, subpackage, sterilizing, the Chinese medicine acetum (the clear vinegar drink of blood fat) of hyperlipemia must be treated; Drink 100ml, every day 2-3 time, 30 days was 1 course for the treatment of at every turn.