CN104706446A - Bionic bone trabecula cervical vertebral fusion cage and manufacturing method thereof - Google Patents
Bionic bone trabecula cervical vertebral fusion cage and manufacturing method thereof Download PDFInfo
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- CN104706446A CN104706446A CN201510129242.5A CN201510129242A CN104706446A CN 104706446 A CN104706446 A CN 104706446A CN 201510129242 A CN201510129242 A CN 201510129242A CN 104706446 A CN104706446 A CN 104706446A
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Abstract
The invention discloses a bionic bone trabecula cervical vertebral fusion cage. The bionic bone trabecula cervical vertebral fusion cage is characterized in that a body of the cervical vertebral fusion cage is in the shape of a hexagonal prism, the interior of the body is in the shape of a three-dimensional net, and square through holes (1) are formed in the middles of the upper end face, the lower end face, the front end face and the rear end face of the body respectively. A manufacturing method of the bionic bone trabecula cervical vertebral fusion cage comprises the following steps that 1, original parameters of the bone trabecula are calculated; 2, a target model is established; 3, specific hole unit bodies are stacked within the boundary range of the target model disorderly, the sizes of the hole unit bodies, the distance between hole units, the sizes of ribs in the hole unit bodies, the sizes of connecting ribs between the hole unit bodies and the precision and appearance precision of an integrated bone trabecula structure are set, and finally the original target model is deleted, and the bone trabecula structure obtained after filling is reserved. According to the bionic bone trabecula cervical vertebral fusion cage and the manufacturing method of the bionic bone trabecula cervical vertebral fusion cage, a cancellous bone structure of a human body is simulated in the microstructure aspect through a 3D printing product, and the technical problems that according to a traditional centrum fusion cage, only the mechanical supporting function is achieved, and a formed bone can not be induced to grow are solved.
Description
Technical field
The present invention relates to the apparatus of corpus vertebrae surgical operation, particularly relate to a kind of bionical bone trabecular cervical vertebral fusion cage and preparation method thereof.
Background technology
Tradition intervertebral fusion apparatus adopts macromolecular material or metal material machining to form, and can only play the effect of physical support in human body, but exists and can not grow into by induced osteogenesis, can not reach the technological deficiency improving spinal fusion rate.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of bionical bone trabecular cervical vertebral fusion cage and preparation method thereof, overcomes the shortcoming of prior art.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of bionical bone trabecular cervical vertebral fusion cage, this apparatus main body is six prism columns, and inside is solid netted, and middle part that is upper and lower and front/rear end all has square through hole.
Described apparatus main body its right end face is also provided with round screw thread hole.
Described device top and bottom and face, left and right is densely arranged manhole, top and bottom also have prismatic groove.
Described device front/rear end is densely arranged scallop hole.
Described apparatus main body material adopts Ti6A4V titanium alloy powder.
Present invention also offers described bionical bone trabecular cervical vertebral fusion cage manufacture method, comprise the following steps:
(1) raw bone girder parameter measurement:
Neck 2 to neck 7 vertebral body is carried out to the CT helical scanning of full vertebral body;
Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower;
The process that threshold value is 250HU pixel is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure; Further binary conversion treatment, makes image transform into bianry image;
Establish with the other target measurement district opening graphical analysis, vertebral body center, line length of going forward side by side is calibrated;
Adopt particle quantitative system, the input of image adopts shooting mode;
Grafting Cancellous Bone Bolt girder granule in described image is defined as granule;
By measuring, calculating the bone trabecular average pore size of cervical vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of cervical vertebra and voidage;
(2) object module is set up:
Use Three-dimensional Design Software UG, design the model of the bone trabecula fusion device done of drawing up; After microcomputer modelling, 3D prints, and then on 3D printing device, produces product;
(3) unordered accumulation specific hole cell cube in the bounds of object module; The size of dowel, overall trabecular bone structure precision and outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube;
Finally delete original object module, retain the trabecular bone structure after filling.
The CT helical scanning condition of described full vertebral body is 120KV, 210mA, 1 cycle per second;
Described establishment opens 10mm, the target measurement district of the graphical analysis of 400mm2 altogether so that vertebral body center is other, and length calibration;
Described employing particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, and the input of image adopts shooting mode, and resolution is 625 lines, 50/second; Adopt full-automatic function.
The index of described graphical analysis comprises: girder amounts of particles in (1) target measurement district; (2) girder particle diameter; (3) girder granule average major axis; (4) girder granule average minor axis; (5) the average flexibility of girder granule.
Need after described formation bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then need to redesign parameter, refill, remeasure after completing;
The original object module of described last deletion, retains the trabecular bone structure after filling, then adds compact texture, be final cartilage pad bone trabecula model.
Described photographic head model is the CCD-MTV-1881CB of Min Tron.
The present invention adopts technique scheme to have following technique effect:
Instant invention overcomes the effect that traditional intervertebral fusion apparatus can only play physical support in human body, but exist and can not grow into by induced osteogenesis, the technological deficiency improving spinal fusion rate can not be reached.Adopt 3D printing technique, bionical in microstructure, can grow into by induced osteogenesis, reach and improve the effect of spinal fusion rate.This device realizes the Bionic Design to bone trabecular internal mechanism by 3D printing technique, and the inter vertebral fusing device of unique reticulated structure can bear the larger extruding force effect of vertebra, has good medical recovery effects.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, the invention will be further described
Fig. 1 is overall structure schematic diagram of the present invention
Fig. 2 is vertical cross section figure of the present invention
Fig. 3 is top view of the present invention
Fig. 4 is scheme of installation of the present invention
Wherein, 1-square through hole, 2-threaded hole, 3-manhole, 4-prismatic groove, 5-scallop hole
Detailed description of the invention
The bionical bone trabecular cervical vertebral fusion cage of one as shown in Figure 1, Figure 2, Figure 3, Figure 4, this apparatus main body is six prism columns, and inside is solid netted, and middle part that is upper and lower and front/rear end all has square through hole 1.Described apparatus main body its right end face is also provided with round screw thread hole 2.Described device top and bottom and face, left and right is densely arranged manhole 3, top and bottom also have prismatic groove 4.Described device front/rear end is densely arranged scallop hole 5.Described apparatus main body material can adopt Ti6A4V titanium alloy powder.
Manufacture method, comprises the following steps:
(1) raw bone girder parameter measurement:
Neck 2 to neck 7 vertebral body is carried out to the CT helical scanning of full vertebral body, condition is 120KV, 210mA, 1 cycle per second; Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower; The process that threshold value is 250HU is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure, adopt the binary conversion treatment function of this machine further, make image transform into bianry image.
Establish and open 10mm, the target measurement district of the graphical analysis of 400mm2 altogether so that vertebral body center is other, and length calibration.Adopt TJTY-300V1.0 particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, the input of image adopts shooting mode, photographic head model is the CCD-MTV-1881CB of Min Tron, and its resolution is 625 lines, 50/second.Adopt its full-automatic function to reduce the interference of subjective factors.Grafting Cancellous Bone Bolt girder granule in image is defined as granule.The index of graphical analysis comprises: girder amounts of particles (Total Number of Objects, TNO) in (1) target measurement district; (2) girder particle diameter (Mean Diameter, MD); (3) girder granule average major axis (Mean Max-Axis, MMA); (4) girder granule average minor axis (Mean Min-Axis, MNA); (5) the average flexibility of girder granule (Thin-D).
By measuring, calculating the bone trabecular average pore size of cervical vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of cervical vertebra and voidage.
(2) object module is set up
Use Three-dimensional Design Software UG, design the model of the bone trabecula fusion device done of drawing up, as depicted in figs. 1 and 2.
(3) unordered accumulation specific hole cell cube in the bounds of object module, the size of dowel and overall trabecular bone structure precision, outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube, finally delete original object module, retain the trabecular bone structure after filling.
The performance indications of product of the present invention: (1) porosity is not less than 70%, pore diameter range 400-600 μm: the present invention with human body spongy bone for data model, between each parameter region of Accurate Measurement Grafting Cancellous Bone Bolt girder, by adjustment bone trabecula aperture, porosity, bone trabecula diameter technological parameter, realize control to bone fusion device pore structure, make porosity be not less than 70%, aperture 400-600 μm.
Effect after as shown in Figure 1 and Figure 2 hole cell cube being filled; After parameter setting completes as shown in Figure 3, namely form trabecular bone structure after deleting original filling objective body, need after forming bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then need to redesign parameter, refill, remeasure after completing; Add compact texture shown in Fig. 4, be final cartilage pad bone trabecula model.
Claims (10)
1. a bionical bone trabecular cervical vertebral fusion cage, is characterized in that: this apparatus main body is six prism columns, and inside is solid netted, and middle part that is upper and lower and front/rear end all has square through hole (1).
2. the bionical bone trabecular cervical vertebral fusion cage of one according to claim 1, is characterized in that: described apparatus main body its right end face is also provided with round screw thread hole (2).
3. the bionical bone trabecular cervical vertebral fusion cage of one according to claim 1, is characterized in that: described device top and bottom and face, left and right is densely arranged manhole (3), and top and bottom also have prismatic groove (4).
4. the bionical bone trabecular cervical vertebral fusion cage of one according to claim 1, is characterized in that: described device front/rear end is densely arranged scallop hole (5).
5. the bionical bone trabecular cervical vertebral fusion cage of one according to claim 1, is characterized in that: described apparatus main body material adopts Ti6A4V titanium alloy powder.
6. the bionical bone trabecular cervical vertebral fusion cage manufacture method of the one of claim 1-5, comprises the following steps:
(1) raw bone girder parameter measurement:
Neck 2 to neck 7 vertebral body is carried out to the CT helical scanning of full vertebral body;
Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower;
The process that threshold value is 250HU pixel is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure; Further binary conversion treatment, makes image transform into bianry image;
Establish with the other target measurement district opening graphical analysis, vertebral body center, line length of going forward side by side is calibrated;
Adopt particle quantitative system, the input of image adopts shooting mode;
Grafting Cancellous Bone Bolt girder granule in described image is defined as granule;
By measuring, calculating the bone trabecular average pore size of cervical vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of cervical vertebra and voidage;
(2) object module is set up:
Use Three-dimensional Design Software UG, design the model of the bone trabecula fusion device done of drawing up;
(3) unordered accumulation specific hole cell cube in the bounds of object module; The size of dowel, overall trabecular bone structure precision and outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube;
Finally delete original object module, retain the trabecular bone structure after filling.
7. the bionical bone trabecular cervical vertebral fusion cage manufacture method of one according to claim 6,
The CT helical scanning condition of described full vertebral body is 120KV, 210mA, 1 cycle per second;
Described establishment opens 10mm so that vertebral body center is other, 400mm altogether
2the target measurement district of graphical analysis, and length calibration;
Described employing particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, and the input of image adopts shooting mode, and resolution is 625 lines, 50/second; Adopt full-automatic function.
8. the bionical bone trabecular cervical vertebral fusion cage manufacture method of the one according to claim 6 or 7,
The index of described graphical analysis comprises: girder amounts of particles in (1) target measurement district; (2) girder particle diameter; (3) girder granule average major axis; (4) girder granule average minor axis; (5) the average flexibility of girder granule.
9. the bionical bone trabecular cervical vertebral fusion cage manufacture method of one according to claim 6, needs after described formation bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then needs to redesign parameter, refill, remeasures after completing.
10. the bionical bone trabecular cervical vertebral fusion cage manufacture method of one according to claim 6, the original object module of described last deletion, retains the trabecular bone structure after filling, then adds compact texture, be final cartilage pad bone trabecula model.
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| CN105581860A (en) * | 2016-01-11 | 2016-05-18 | 李鹏 | 3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof |
| CN105662660A (en) * | 2016-01-13 | 2016-06-15 | 李鹏 | 3D printing bionic bone trabecular structure lumbar vertebra fusion device, manufacturing method and application |
| CN106073952A (en) * | 2016-07-18 | 2016-11-09 | 中国人民解放军第二军医大学第二附属医院 | A kind of vertebral body booster treating compression fracture of vertabral body |
| CN106073951A (en) * | 2016-05-24 | 2016-11-09 | 北京市春立正达医疗器械股份有限公司 | A kind of 3D prints the low incisura fusion device of metal bone trabecula cervical vertebra |
| CN106618804A (en) * | 2016-12-28 | 2017-05-10 | 嘉思特华剑医疗器材(天津)有限公司 | Bone induction differentiated metal bone trabecula knee joint prosthesis and preparation method thereof |
| CN107280824A (en) * | 2017-05-12 | 2017-10-24 | 武汉理工大学 | A kind of bionical artificial spinal prosthesis with flange |
| CN107468382A (en) * | 2017-08-23 | 2017-12-15 | 北京爱康宜诚医疗器材有限公司 | Ankle joint fusion cage |
| CN107625564A (en) * | 2017-10-20 | 2018-01-26 | 常州华森医疗器械有限公司 | Lumbar intervertebral fusion device |
| CN107802383A (en) * | 2017-11-16 | 2018-03-16 | 天津正天医疗器械有限公司 | Lumbar vertebrae Invasive lumbar fusion device with Bone Ingrowth micropore |
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| CN109124833A (en) * | 2018-11-08 | 2019-01-04 | 北京爱康宜诚医疗器材有限公司 | Artificial dentata |
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| CN112402065A (en) * | 2019-08-23 | 2021-02-26 | 北京智塑健康科技有限公司 | Manufacturing method, system and device of fusion device and storage medium thereof |
| CN112402063A (en) * | 2019-08-23 | 2021-02-26 | 北京智塑健康科技有限公司 | A model construction method, system, device and readable storage medium of a bone structure prosthesis |
| CN112402063B (en) * | 2019-08-23 | 2024-12-20 | 智塑健康科技(嘉兴)有限公司 | A method, system, device and readable storage medium for building a model of a bone structure prosthesis |
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