CN104667066A - Medicine for treating diarrhea of children - Google Patents
Medicine for treating diarrhea of children Download PDFInfo
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- CN104667066A CN104667066A CN201510147581.6A CN201510147581A CN104667066A CN 104667066 A CN104667066 A CN 104667066A CN 201510147581 A CN201510147581 A CN 201510147581A CN 104667066 A CN104667066 A CN 104667066A
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- 239000003814 drug Substances 0.000 title claims abstract description 19
- 206010012735 Diarrhoea Diseases 0.000 title abstract description 11
- 229940079593 drug Drugs 0.000 title description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 208000019637 Infantile Diarrhea Diseases 0.000 claims description 10
- 241000208340 Araliaceae Species 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 235000019057 Raphanus caudatus Nutrition 0.000 claims description 7
- 244000088415 Raphanus sativus Species 0.000 claims description 7
- 235000011380 Raphanus sativus Nutrition 0.000 claims description 7
- 210000000952 spleen Anatomy 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 208000004880 Polyuria Diseases 0.000 abstract description 3
- 230000035619 diuresis Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 240000002791 Brassica napus Species 0.000 abstract 1
- 235000011293 Brassica napus Nutrition 0.000 abstract 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 abstract 1
- 240000000425 Chaenomeles speciosa Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 241001522129 Pinellia Species 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000002671 adjuvant Substances 0.000 description 7
- 239000008187 granular material Substances 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- 208000019790 abdominal distention Diseases 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229910021647 smectite Inorganic materials 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000036649 Dysbacteriosis Diseases 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- 208000014540 Functional gastrointestinal disease Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 201000007637 bowel dysfunction Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000003866 digestant Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a medicine for treating diarrhea of children. The medicine is prepared from the following components in parts by weight: 2-10 parts of lobed kudzuvin roots, 5-10 parts of rhizoma dioscoreae, 2-5 parts of pinellia tubers, 2-10 parts of dried tangerine peels, 2-8 parts of common floweringquince peels, 1-2 parts of ginseng, 3-8 parts of black soybean seeds, 0.1-1 part of plantain herb, 1-5 parts of malt and 1-5 parts of liquorice roots. To improve the treatment effect of the medicine, 0.1-0.5 part of apple peels and 0.1-0.3 part of turnip peels can be added into the formula. The medicine provided by the invention has the efficacies of strengthening the spleen and the stomach, clearing damp, promoting diuresis, regulating the middle warmer and relieving diarrhea, is safe and efficient and is very suitable for being drunk by children.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of medicine for the treatment of infantile diarrhea.
Background technology
Infantile diarrhea is a kind of common digestant for baby tract disease, has a strong impact on the healthy of infant.Main feature is that times of defecation increases and character changes, can with the symptoms such as heating, vomiting, stomachache and water, electrolyte, acid base imbalance in various degree.Cause the reason of diarrhoea to be divided into non-infectious and infectious two large factors, wherein pulmonary infection is often by unhygienic diet or excessively caused by slow reason, causes the symptoms such as infant dysbacteriosis, intestinal mucosal injury, bowel dysfunction.Infectious factors is mainly parasite, fungus, antibacterial and virus etc.Diarrhoea belongs to " having loose bowels " category in the traditional Chinese medical science, caused by insufficiency of the spleen, insufficiency of the spleen with have loose bowels closely related, taste normally then can not cause diarrhoea.The morbidity season of infantile diarrhea mostly is autumn and winter season, infant the spleen tending to insufficiency usually, and easily by internal and external factor is disturbed, at multiple sense wind and cold, intemperance of taking food, taste are very easily injured, and paddy is anti-stagnant, and water is anti-wet, failure of the spleen to transport and transform, causes diarrhoea.Generally use dioctahedral smectite suppresses inflammatory reaction and the detoxifying function of pathogen initiation clinically, thus plays the effect for the treatment of diarrhoea, but the effect of the auxiliary reparation suffered for want of medical supplies and adjustment body fluid.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of medicine for the treatment of infantile diarrhea, and this medicine has invigorating the spleen and regulating the stomach, promoting diuresis to eliminate damp pathogen and middle antidiarrheal, safe and efficient, the advantage of wide adaptability.
Technical scheme provided by the invention is a kind of medicine for the treatment of infantile diarrhea, comprises the component of following weight portion: Radix Puerariae 2 ~ 10 parts, Rhizoma Dioscoreae 5 ~ 10 parts, the Rhizoma Pinelliae 2 ~ 5 parts, Pericarpium Citri Reticulatae 2 ~ 10 parts, Fructus Chaenomelis skin 2 ~ 8 parts, Radix Ginseng 1 ~ 2 part, 3 ~ 8 parts, Semen sojae atricolor, Herba Plantaginis 0.1 ~ 1 part, 1 ~ 5 part, Fructus Hordei Germinatus, 1 ~ 5 part, Radix Glycyrrhizae.
As preferably, also comprise the component of following weight portion: Pericarpium Mali pumilae 0.1 ~ 0.5 part.
Further preferably, the component of following weight portion is also comprised: peel of Raphanus sativus L. 0.1 ~ 0.3 part.
Apple flakes after Pericarpium Mali pumilae and peel of Raphanus sativus L. are and dry and peel of Raphanus sativus L., its effect is to provide zinc element, can help to improve therapeutic effect, improves infant immunologic function.
Preparation method of the present invention is: Radix Puerariae 2 ~ 10 parts, Rhizoma Dioscoreae 5 ~ 10 parts, the Rhizoma Pinelliae 2 ~ 5 parts, Pericarpium Citri Reticulatae 2 ~ 10 parts, Fructus Chaenomelis skin 2 ~ 8 parts, Radix Ginseng 1 ~ 2 part, 3 ~ 8 parts, Semen sojae atricolor, Herba Plantaginis 0.1 ~ 1 part, 1 ~ 5 part, Fructus Hordei Germinatus and 1 ~ 5 part, Radix Glycyrrhizae are decocted with water 1 ~ 3 time, each decoction 1 ~ 3h, merge decoction liquor, filter, at simmer down to 60 DEG C, relative density is the extractum of 1.1 ~ 1.30, then adds the granule that applicable child administration made by adjuvant.
The preparation method of another technical scheme of the present invention is: by Radix Puerariae 2 ~ 10 parts, Rhizoma Dioscoreae 5 ~ 10 parts, the Rhizoma Pinelliae 2 ~ 5 parts, Pericarpium Citri Reticulatae 2 ~ 10 parts, Fructus Chaenomelis skin 2 ~ 8 parts, Radix Ginseng 1 ~ 2 part, 3 ~ 8 parts, Semen sojae atricolor, Herba Plantaginis 0.1 ~ 1 part, 1 ~ 5 part, Fructus Hordei Germinatus and 1 ~ 5 part, Radix Glycyrrhizae decoct with water 1 ~ 3 time, each decoction 1 ~ 3h, merge decoction liquor, filter, at simmer down to 60 DEG C, relative density is the extractum of 1.1 ~ 1.30, then by the Pericarpium Mali pumilae 0.1 ~ 0.5 part dried and/or peel of Raphanus sativus L. 0.1 ~ 0.3 part pulverizing of drying, mix with above-mentioned extractum, then add adjuvant and make granule.
Medicine of the present invention has effect of invigorating the spleen and regulating the stomach, promoting diuresis to eliminate damp pathogen and middle antidiarrheal, safe and efficient, very applicable child administration.
Detailed description of the invention
The present invention is further elaborated for following specific embodiment, but not as a limitation of the invention.
Embodiment 1
Radix Puerariae 2 parts, Rhizoma Dioscoreae 5 parts, the Rhizoma Pinelliae 2 parts, Pericarpium Citri Reticulatae 2 parts, Fructus Chaenomelis skin 2 parts, Radix Ginseng 1 part, 3 parts, Semen sojae atricolor, Herba Plantaginis 0.1 part, 1 part, Fructus Hordei Germinatus and 1 part, Radix Glycyrrhizae are decocted with water 1 time, each decoction 1h, decoction liquor is filtered, at filtrate simmer down to 60 DEG C, relative density is the extractum of 1.1, then adds the granule that applicable child administration made by adjuvant.
Embodiment 2
Radix Puerariae 10 parts, Rhizoma Dioscoreae 10 parts, the Rhizoma Pinelliae 5 parts, Pericarpium Citri Reticulatae 10 parts, Fructus Chaenomelis skin 8 parts, Radix Ginseng 2 parts, 8 parts, Semen sojae atricolor, Herba Plantaginis 1 part, 5 parts, Fructus Hordei Germinatus and 5 parts, Radix Glycyrrhizae are decocted with water 3 times, each decoction 3h, merge decoction liquor, filter, at simmer down to 60 DEG C, relative density is the extractum of 1.30, then adds the granule that applicable child administration made by adjuvant.
Embodiment 3
Radix Puerariae 2 parts, Rhizoma Dioscoreae 10 parts, the Rhizoma Pinelliae 2 parts, Pericarpium Citri Reticulatae 10 parts, Fructus Chaenomelis skin 2 parts, Radix Ginseng 2 parts, 3 parts, Semen sojae atricolor, Herba Plantaginis 1 part, 1 part, Fructus Hordei Germinatus and 5 parts, Radix Glycyrrhizae are decocted with water 1 time, decoct 3h, decoction liquor is filtered, at simmer down to 60 DEG C, relative density is the extractum of 1.1 ~ 1.30, the Pericarpium Mali pumilae 0.1 part pulverizing of then will dry, mix with above-mentioned extractum, then add adjuvant and make granule.
Embodiment 4
Radix Puerariae 10 parts, Rhizoma Dioscoreae 5 parts, the Rhizoma Pinelliae 5 parts, Pericarpium Citri Reticulatae 2 parts, Fructus Chaenomelis skin 8 parts, Radix Ginseng 1 part, 8 parts, Semen sojae atricolor, Herba Plantaginis 0.1 part, 5 parts, Fructus Hordei Germinatus and 1 part, Radix Glycyrrhizae are decocted with water 3 times, each decoction 1h, merge decoction liquor, filter, at simmer down to 60 DEG C, relative density is the extractum of 1.30, the peel of Raphanus sativus L. 0.3 part pulverizing of then will dry, mixes with above-mentioned extractum, then adds adjuvant and make granule.
Embodiment 5
Radix Puerariae 8 parts, Rhizoma Dioscoreae 6 parts, the Rhizoma Pinelliae 3 parts, Pericarpium Citri Reticulatae 5 parts, Fructus Chaenomelis skin 5 parts, Radix Ginseng 1.5 parts, 5 parts, Semen sojae atricolor, Herba Plantaginis 0.5 part, 3 parts, Fructus Hordei Germinatus and 3 parts, Radix Glycyrrhizae are decocted with water 2 times, each decoction 2h, merge decoction liquor, filter, at simmer down to 60 DEG C, relative density is the extractum of 1.20, then by the Pericarpium Mali pumilae 0.3 part dried and the peel of Raphanus sativus L. 0.2 part pulverizing of drying, mix with above-mentioned extractum, then add adjuvant and make granule.
For verifying the clinical efficacy of medicine of the present invention, carry out following clinical trial.
1, clinical data
Select 200 routine infantile diarrhea patients, the age is 5 months to 5 years old, is diarrhoea, just secondaryly increases, and stool is in water sample or egg style.Wherein with heating, vomiting, abdominal distention person 61 example, without obviously heating, vomiting, abdominal distention person 39 example, stool microscopy is without leukocyte, and without erythrocyte, part has non-digest, and stool is cultivated negative.Blood routine examination leukocyte is normal or a little more than normal value, percentage of lymphocyte is all greater than 40%.Complete group of infant is divided into 5 groups by random sampling method, is respectively experimental group 1 ~ 4 and matched group, often organizes 40 examples.
2, Therapeutic Method
Matched group and experimental group all carry out conventional symptomatic treatment, as given to correct acidosis, fluid infusion and cooling measure.On the basis of conventional therapy, the oral dioctahedral smectite of matched group, oral half an hour ante cibum, every day 3 times, continuous oral three days, infant is greater than 3 years old, each 1 bag; Infant 1 ~ 3 years old, each 0.5 bag; Infant is less than 1 years old, each 1/3 bag.The medicine of experimental group oral embodiment 2 ~ 5 half an hour ante cibum, every day 3 times, take three days continuously, infant is greater than 3 years old, each serving with being equivalent to 0.1g crude drug; Infant 1 ~ 3 years old, each serving with being equivalent to 0.05g crude drug; Infant is less than 1 years old, at every turn with being equivalent to 0.03g crude drug.
3, efficacy determination
Effective: stool frequency is normal, stool indices recovers normal.
Effective: stool frequency is 3 ~ 5 times/d, stool indices takes a turn for the better to some extent.
Invalid: stool frequency and indices unchanged or increase the weight of.
4, result
| Group | Effective | Effectively | Invalid | Total effective rate (%) |
| Experimental group 1 | 28 | 7 | 5 | 87.5 |
| Experimental group 2 | 25 | 9 | 6 | 85 |
| Experimental group 3 | 30 | 7 | 3 | 92.5 |
| Experimental group 4 | 32 | 6 | 2 | 95 |
| Matched group | 21 | 10 | 9 | 77.5 |
Claims (3)
1. treat a medicine for infantile diarrhea, it is characterized in that: the component comprising following weight portion: Radix Puerariae 2 ~ 10 parts, Rhizoma Dioscoreae 5 ~ 10 parts, the Rhizoma Pinelliae 2 ~ 5 parts, Pericarpium Citri Reticulatae 2 ~ 10 parts, Fructus Chaenomelis skin 2 ~ 8 parts, Radix Ginseng 1 ~ 2 part, 3 ~ 8 parts, Semen sojae atricolor, Herba Plantaginis 0.1 ~ 1 part, 1 ~ 5 part, Fructus Hordei Germinatus, 1 ~ 5 part, Radix Glycyrrhizae.
2. the medicine for the treatment of infantile diarrhea according to claim 1, is characterized in that: the component also comprising following weight portion: Pericarpium Mali pumilae 0.1 ~ 0.5 part.
3. the medicine for the treatment of infantile diarrhea according to claim 1 and 2, is characterized in that: the component also comprising following weight portion: peel of Raphanus sativus L. 0.1 ~ 0.3 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510147581.6A CN104667066A (en) | 2015-03-31 | 2015-03-31 | Medicine for treating diarrhea of children |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510147581.6A CN104667066A (en) | 2015-03-31 | 2015-03-31 | Medicine for treating diarrhea of children |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104667066A true CN104667066A (en) | 2015-06-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510147581.6A Pending CN104667066A (en) | 2015-03-31 | 2015-03-31 | Medicine for treating diarrhea of children |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104667066A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824285A (en) * | 2005-12-26 | 2006-08-30 | 罗忠 | Compound Chinese medicinal extract possessing stomach fortifying food digesting action and its preparation |
| CN103638372A (en) * | 2013-11-14 | 2014-03-19 | 谭晓明 | Traditional Chinese medicine composition, preparation method and application thereof |
-
2015
- 2015-03-31 CN CN201510147581.6A patent/CN104667066A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824285A (en) * | 2005-12-26 | 2006-08-30 | 罗忠 | Compound Chinese medicinal extract possessing stomach fortifying food digesting action and its preparation |
| CN103638372A (en) * | 2013-11-14 | 2014-03-19 | 谭晓明 | Traditional Chinese medicine composition, preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 曹辅发: "小儿腹泻的药物治疗", 《新医学》 * |
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Application publication date: 20150603 |