CN104665922B - Marshall ligament absolute ethyl alcohol ablation system - Google Patents

Abstract

The invention relates to an anhydrous ethanol ablation system for Marshall ligament, comprising: an electrophysiological catheter for imaging mapping, a special guiding sheath, a guiding steel wire, and a chemical ablation balloon catheter. Marshall ligament anhydrous ethanol ablation system, the angiographic mapping electrophysiological catheter is inserted through the guide sheath into the coronary sinus through the femoral vein, the coronary venous potential is recorded, and retrograde angiography is performed to display the vein of Marshall, along the angiographic mapping electrophysiological The catheter pushes the guiding sheath to the opening of the coronary vein, withdraws the angiographic mapping electrophysiological catheter, sends a guide wire along the central lumen of the guiding sheath into the coronary vein, and guides the chemical ablation balloon into the vein of Marshall. The guide wire also has the function of recording Marshall potential, and records the potential change before and after ablation. The electrodes can be designed with a gap of 2 mm, and a total of 10 electrodes are designed. Then use the chemical ablation balloon catheter to inject absolute ethanol through its distal side cavity to implement chemical ablation.

Description

Marshall Ligament Ethanol Ablation System

technical field

The invention relates to the technical field of medical measurement, in particular to a Marshall ligament absolute ethanol ablation system.

Background technique

As we all know, atrial fibrillation (abbreviated as atrial fibrillation) is the most common clinical sustained arrhythmia. Existing studies have found that the ligament of Marshall (LOM) plays an important role in the occurrence and maintenance of atrial fibrillation.

The ligament of Marshall is a fibrous cord-like structure formed after the degeneration of the left superior vena cava during the embryonic period. It runs between the left atrial appendage and the left pulmonary vein, and contains small veins (Marshall veins), myocardial fibers (Marshall bundles) and nerve tissues. Marshall's vein is the left atrial oblique vein, which originates between the left upper and left lower pulmonary veins, runs obliquely downward, receives venous blood from the posterior wall of the left atrium, and flows into the coronary sinus at an acute angle. The cardiomyocytes in the bundle of Marshall are surrounded by fibrous connective tissue and directly connect with the muscle bundle of the coronary sinus and the adjacent atrial myocardium at the point where the vein of Marshall joins the coronary sinus. Studies have confirmed that electrical activity can be recorded in the ligament of Marshall, which plays an important role in the initiation and maintenance of atrial fibrillation. Radiofrequency ablation or ethanol perfusion can be used to damage the muscle bundles in the ligament of Marshall to achieve the purpose of treating atrial fibrillation. The key site of ablation is the junction of the Marshall ligament and the coronary sinus, and the end point of ablation is the complete disappearance of the potential of the Marshall ligament. In addition, Marshall's intravenous infusion of absolute ethanol can also significantly improve the rate of mitral valve isthmus block and improve the success rate of catheter ablation of persistent atrial fibrillation.

Contents of the invention

The technical problem to be solved by the present invention is to address the deficiencies of the prior art, and propose a Marshall ligament absolute ethanol ablation system, which can accurately and quickly locate the Marshall vein, and record the change of Marshall potential before and after ablation, so as to achieve good diagnosis and treatment purposes.

For this purpose, the present invention proposes an anhydrous ethanol ablation system for Marshall's ligament, including: an electrophysiological catheter for imaging mapping, a special guide sheath, a guide wire, and a chemical ablation balloon catheter;

The angiographic mapping electrophysiological catheter is used to insert the coronary sinus through the femoral vein, record the coronary venous potential, and perform retrograde angiography to display the vein of Marshall;

The special guide sheath is used for intubation to the coronary sinus through the femoral vein, and the chemical ablation balloon catheter is sent through the central lumen;

The guide wire is used to guide the chemical ablation balloon into the Marshall vein. The guide wire also has the function of recording the Marshall potential, and records the potential change before and after ablation. Among them, there are 2 mm gaps between multiple electrodes, and a total of 10 electrode pairs;

The chemical ablation balloon catheter is used to inject absolute ethanol through its proximal side cavity to perform chemical ablation, wherein the chemical ablation balloon catheter is set at 3.5F;

Wherein, the contrast mapping electrophysiological catheter includes a balloon, a mapping electrode tip, a balloon inflation connector, a contrast agent connector, a mapping electrode connector, and a catheter main tube;

The inflation joint of the balloon is connected to the air guide tube of the balloon, the air guide tube of the balloon is connected to the balloon, the joint of the contrast agent is connected with the contrast cavity of the catheter, and the connector of the mapping electrode passes through the electrode protection tube Reach the position of the electrode tip;

The special guide sheath is used to guide the chemical ablation balloon catheter into the coronary vein;

The balloon inflation joint on the chemical ablation balloon catheter is connected to the balloon air guide tube, the balloon air guide tube is connected to the balloon, the chemical ablation joint is connected to the ablation cavity of the catheter, and the ablation cavity has Two or more spray holes. The balloon 0102 is thicker than the inner diameter of the blood vessel at the diseased site, so as to block the blood flow. The ejection holes 0204 are multiple closely arranged structures so that the contrast agent can be injected into the blood vessel smoothly. The catheter tip has a soft tip 0203 to ensure that the catheter will not damage the blood vessel.

Specifically, the chemical ablation balloon catheter includes a guide wire and an ablation balloon catheter.

Specifically, the guide wire includes a tail connector, a guide wire body, and a head-end electrode. .

Specifically, the inner diameter of the balloon is larger than the inner diameter of the blood vessel at the diseased site, so as to block blood flow.

Specifically, the injection holes are a plurality of closely-packed structures for injecting the contrast agent into the inside of the blood vessel.

Specifically, the catheter tip of the chemical ablation balloon catheter is provided with a soft tip for protecting the catheter from damaging blood vessels.

Specifically, there are two or more injection holes on the contrast cavity.

Specifically, each pin of the mapping electrode connector corresponds to one electrode.

Specifically, the electrodes are connected to the corresponding pins on the connecting head of the mapping electrode through wires.

Specifically, the spacing between the electrodes is equal, wherein there are two or more electrodes.

The invention relates to an anhydrous ethanol ablation system for Marshall ligament, comprising: an electrophysiological catheter for imaging mapping, a special guide sheath, a guide wire, and a chemical ablation balloon catheter; The catheter is passed through the guide sheath, inserted into the coronary sinus via the femoral vein, the coronary venous potential is recorded, and retrograde angiography is performed to display the vein of Marshall, the guide sheath is pushed along the angiographic mapping electrophysiological catheter to the coronary vein opening, and the angiography is withdrawn The electrophysiological catheter was mapped, a guide wire was sent along the center lumen of the guide sheath into the coronary vein, and a chemical ablation balloon was guided into the vein of Marshall. The guide wire also has the function of recording Marshall potential, and records the potential change before and after ablation. The electrodes can be designed with a gap of 2 mm, and a total of 10 electrodes are designed. Then use the chemical ablation balloon catheter to inject absolute ethanol through its distal side cavity to implement chemical ablation.

The above description is only an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention, it can be implemented according to the contents of the description, and in order to make the above and other purposes, features and advantages of the present invention more obvious and understandable , the specific embodiments of the present invention are enumerated below.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

The features and advantages of the present invention will be more clearly understood by referring to the accompanying drawings, which are schematic and should not be construed as limiting the invention in any way. In the accompanying drawings:

Fig. 1 shows the schematic structural diagram of the coordination of the chemical ablation balloon catheter and the guide wire in the Marshall ligament absolute ethanol ablation system of the present invention;

Fig. 2 shows the structure diagram of the chemical ablation balloon catheter in the Marshall ligament absolute ethanol ablation system of the present invention;

Fig. 3 shows the structure diagram of the guide wire in the Marshall ligament absolute ethanol ablation system of the present invention;

Fig. 4 shows the structural representation of the guiding sheath in the absolute ethanol ablation system for Marshall's ligament of the present invention;

Fig. 5 shows a schematic structural diagram of the electrophysiological catheter for contrast mapping in the Marshall ligament absolute ethanol ablation system of the present invention;

Fig. 6 shows the structure diagram of the tail of the contrast mapping electrophysiological catheter in the Marshall ligament absolute ethanol ablation system of the present invention;

Fig. 7 shows a local structural diagram of the angiographic cavity of the electrophysiological catheter for contrast mapping in the absolute ethanol ablation system for Marshall's ligament of the present invention.

detailed description

Embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only used to illustrate the present invention, but can not be used to limit the scope of the present invention.

In order to better understand and apply the Marshall ligament absolute ethanol ablation system proposed by the present invention, it will be described in detail with the following figures as examples.

As shown in FIG. 1 , the present invention provides an anhydrous ethanol ablation system for Marshall ligament, including: an electrophysiological catheter for contrast-enhanced mapping, a special guide sheath, a guide wire, and a chemical ablation balloon catheter.

Specifically, the contrast mapping electrophysiological catheter includes a balloon (102), a mapping electrode tip (6), a balloon inflation connector (1), a contrast agent connector (2), a mapping electrode connector (3), a catheter Supervisor (4).

Further, as shown in Figures 2-5, the balloon inflation joint (1) is connected to the balloon airway (101), the balloon airway (101) is linked to the balloon (102), and the contrast medium joint (2) It is connected with the contrast cavity (202) of the catheter. There are two or more injection holes (204) on the contrast cavity (202), and the mapping electrode connector (3) passes through the electrode protection tube (301) Arrive at the position of the electrode tip (6), wherein each core pin of the mapping electrode connector (3) corresponds to an electrode (601), and the electrode (601) is connected to the corresponding mapping electrode connector ( 3) The core pins on the top are connected together, and the distance between the electrodes (601) is equal, and there can be two or more electrodes (601).

Furthermore, the balloon (102) should be thicker than the inner diameter of the blood vessel at the diseased site to achieve the purpose of blocking blood flow, and the injection holes (204) are multiple densely packed structures so that the contrast agent can be smoothly injected into the blood vessel internal.

Furthermore, the electrophysiological catheter for contrast-enhanced mapping also includes a catheter tip, and a smooth and soft tip (602) is provided to ensure that the catheter will not damage blood vessels.

The absolute ethanol ablation system for Marshall's ligament proposed by the present invention also includes: a special guide sheath used for guiding the chemical ablation balloon catheter into the coronary vein.

The Marshall ligament absolute ethanol ablation system proposed by the present invention also includes: a chemical ablation balloon catheter, specifically, the balloon inflation joint (01) on the chemical ablation balloon catheter is connected to the balloon air guide tube (0101), and the balloon guide The trachea (0101) is connected to the balloon (0102); the chemical ablation joint (2) is connected to the ablation cavity (0202) of the catheter, and there are two or more injection holes on the ablation cavity (0202) (0204).

Furthermore, the balloon (0102) should be thicker than the inner diameter of the blood vessel at the diseased site to achieve the purpose of blocking blood flow, and the injection holes (0204) are multiple densely packed structures so that the contrast agent can be injected smoothly Inside the blood vessel.

Furthermore, the catheter tip of the chemical ablation balloon catheter is provided with a soft tip (0203) to ensure that the catheter will not damage blood vessels.

Furthermore, the chemical ablation balloon catheter includes a guide wire and an ablation balloon catheter, wherein the guide wire includes a tail connector, a main body of the guide wire, and a tip electrode.

Furthermore, FIG. 6 is a structural diagram of the tail of the electrophysiological catheter for contrast-enhanced mapping. The main tube 4 of the catheter is divided into three chambers: the balloon inflation connector 1, the contrast agent connector 2, and the mapping electrode connector 3. As shown in FIG. Go to the inside of the blood vessel, and then use an X-ray machine to perform imaging to determine the internal structure of the blood vessel. Then, the angiographic mapping electrophysiological catheter is withdrawn from the blood vessel, passed into the guide sheath, and the guide wire is passed through the central lumen of the guide sheath into the coronary vein. Perform chemical ablation.

The invention relates to an anhydrous ethanol ablation system for Marshall ligament, comprising: an electrophysiological catheter for imaging mapping, a special guide sheath, a guide wire, and a chemical ablation balloon catheter; The catheter is passed through the guide sheath, inserted into the coronary sinus via the femoral vein, the coronary venous potential is recorded, and retrograde angiography is performed to display the vein of Marshall, the guide sheath is pushed along the angiographic mapping electrophysiological catheter to the coronary vein opening, and the angiography is withdrawn The electrophysiological catheter was mapped, a guide wire was sent along the center lumen of the guide sheath into the coronary vein, and a chemical ablation balloon was guided into the vein of Marshall. The guide wire also has the function of recording Marshall potential, and records the potential change before and after ablation. The electrodes can be designed with a gap of 2 mm, and a total of 10 electrodes are designed. Then use the chemical ablation balloon catheter to inject absolute ethanol through its distal side cavity to implement chemical ablation.

The various component embodiments of the present invention may be implemented in hardware, or in software modules running on one or more processors, or in a combination thereof. Those skilled in the art should understand that a microprocessor or a digital signal processor (DSP) may be used in practice to implement some or all functions of some or all components in the device according to the embodiment of the present invention. The present invention can also be implemented as an apparatus or system program (eg, computer program and computer program product) for performing a part or all of the methods described herein. Such a program for realizing the present invention may be stored on a computer-readable medium, or may be in the form of one or more signals. Such a signal may be downloaded from an Internet site, or provided on a carrier signal, or provided in any other form.

Reference herein to "one embodiment," "an embodiment," or "one or more embodiments" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Additionally, please note that examples of the word "in one embodiment" herein do not necessarily all refer to the same embodiment.

In the description provided herein, numerous specific details are set forth. However, it is understood that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure the understanding of this description.

It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The invention can be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In a unit claim enumerating several systems, several of these systems can be embodied by one and the same item of hardware. The use of the words first, second, and third, etc. does not indicate any order. These words can be interpreted as names.

In addition, it should be noted that the language used in the specification has been chosen primarily for the purpose of readability and instruction rather than to explain or delimit the inventive subject matter. Accordingly, many modifications and alterations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the appended claims. With respect to the scope of the present invention, the disclosure of the present invention is intended to be illustrative rather than restrictive, and the scope of the present invention is defined by the appended claims.

Although the embodiments of the present invention have been described in conjunction with the accompanying drawings, those skilled in the art can make various modifications and variations without departing from the spirit and scope of the present invention. within the bounds of the requirements.

Claims (5)

1. Marshall ligament anhydrous ethanol ablation system, characterized in that it includes: an electrophysiological catheter for imaging mapping, a special guiding sheath, a guiding wire, and a chemical ablation balloon catheter; The angiographic mapping electrophysiological catheter is used to insert the coronary sinus through the femoral vein, record the coronary venous potential, and perform retrograde angiography to display the vein of Marshall; The special guide sheath is used for intubation to the coronary sinus through the femoral vein, and the chemical ablation balloon catheter is sent through the central lumen; The guide wire is used to guide the chemical ablation balloon catheter into the vein of Marshall. The guide wire also has the function of recording Marshall potential, and records the potential change before and after ablation. Among them, there is a gap of 2 mm between multiple electrodes, and there are 10 electrodes in total. right; The chemical ablation balloon catheter is used to inject absolute ethanol through its proximal side cavity to perform chemical ablation, wherein the chemical ablation balloon catheter is set at 3.5F; Wherein, the contrast mapping electrophysiological catheter includes a balloon, a mapping electrode tip, a balloon inflation connector, a contrast agent connector, a mapping electrode connector, and a catheter main tube; The inflation joint of the balloon is connected to the air guide tube of the balloon, the air guide tube of the balloon is connected to the balloon, the joint of the contrast agent is connected with the contrast cavity of the catheter, and the connector of the mapping electrode passes through the electrode protection tube Reach the position of the tip of the mapping electrode; The special guide sheath is used to guide the chemical ablation balloon catheter into the coronary vein; The balloon inflation joint on the chemical ablation balloon catheter is connected to the balloon air guide tube, the balloon air guide tube is connected to the balloon, the chemical ablation joint is connected to the ablation cavity of the catheter, and the ablation cavity has Two or more injection holes; the balloon (0102) connected to the chemical ablation balloon catheter is thicker than the inner diameter of the blood vessel at the diseased site to achieve the purpose of blocking blood flow; the injection holes (0204) are A plurality of close-packed structures enable the chemical ablation reagent to be smoothly injected into the blood vessel; the tip of the chemical ablation balloon catheter has a soft tip (0203) to ensure that the catheter will not damage the blood vessel. 2. The absolute ethanol ablation system for Marshall's ligament according to claim 1, wherein the guide wire comprises a tail connector, a guide wire main body and a head-end electrode. 3. The absolute ethanol ablation system for Marshall's ligament according to claim 1, wherein each core pin of said mapping electrode connector corresponds to one electrode. 4 . The Marshall ligament absolute ethanol ablation system according to claim 1 , wherein the electrodes of the contrast-mapping electrophysiological catheter are connected to the core pins on the corresponding mapping electrode connectors through wires. 5. The absolute ethanol ablation system for Marshall's ligament according to claim 1, wherein the distance between the electrodes of the contrast mapping electrophysiological catheter is equal, wherein there are two or more electrodes.