CN104663658A - Sterilizing agent and preparation method thereof - Google Patents
Sterilizing agent and preparation method thereof Download PDFInfo
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- CN104663658A CN104663658A CN201510056085.XA CN201510056085A CN104663658A CN 104663658 A CN104663658 A CN 104663658A CN 201510056085 A CN201510056085 A CN 201510056085A CN 104663658 A CN104663658 A CN 104663658A
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- weight portion
- bactericidal agent
- polylysine
- preparation
- parts
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000003206 sterilizing agent Substances 0.000 title abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- JKWMSGQKBLHBQQ-UHFFFAOYSA-N diboron trioxide Chemical compound O=BOB=O JKWMSGQKBLHBQQ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 108010039918 Polylysine Proteins 0.000 claims abstract description 19
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 10
- 229920002101 Chitin Polymers 0.000 claims abstract description 10
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 10
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 10
- 229920000656 polylysine Polymers 0.000 claims abstract description 10
- 239000003899 bactericide agent Substances 0.000 claims description 32
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 229920000123 polythiophene Polymers 0.000 claims description 8
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 4
- 238000010348 incorporation Methods 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 10
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 7
- 238000011056 performance test Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 210000004215 spore Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a sterilizing agent and a preparation method thereof. The sterilizing agent is prepared from the following components in parts by weight: 8-12 parts of hyaluronic acid, 1-2 parts of boron trioxide, 0.5-2 parts of polylysine, 0.5-1.8 parts of tertiary hexadecarbonic mercaptan, 0.5-1.5 parts of chitin, 5-8 parts of ethyl alcohol and 65-70 parts of water. The invention also provides a preparation method of the sterilizing agent. The sterilizing agent disclosed by the invention has good sterilizing performance, is simple to prepare and can be widely applied to sterilization of various articles.
Description
Technical field
The invention belongs to sterile material field, particularly a kind of bactericidal agent and preparation method thereof.
Background technology
Bactericidal agent is that a kind of requirement for sterilizing kills compared with high energy the chemical high effect disinfectants of various microorganisms comprising bacterial spore, fungal spore.
Bactericidal agent self with active chemical group to contact with microorganism after there is chemical reaction and cause microbial function structural failure, make its loss of life activity, thus reach killing microorganisms object.
Bactericidal agent can be used for clean area space disinfection, desinfection chamber air sterillization, sterile product production equipment surface sterilizing
Along with the continuous progress of people's living standard, increasing people pays close attention to health, also more pays close attention to the quality of living environment.Various bacterium or fungi abrim in our living environment, can be propagated by contact, in order to reduce the probability that people contact with bacterium, reduce ill risk, increasing people pays close attention to disinfection sanitizer.
The disinfection way that past is commonly used is often high temperature or steam sterilization, uniform temperature is reached by heating, thus harmful bacteria is killed, but the mode of steam and heating can be used to carry out disinfection due to not every article, therefore these sterilization methods enjoy restriction.
Chinese patent CN 102657843 A discloses antibacterial peptide composition and method of making the same, this application adopts the method for physically encapsulation, antibacterial peptide containing polylysine is wrapped in degradable high polymer material, thus prepare nanometer to micron-sized microballoon, along with the degraded of material, antibacterial peptide is released gradually.This is because epsilon-polylysine can be used as fungicide active ingredient, all has deactivation to gram-positive bacteria, negative bacterium, mould, yeast, virus.
Summary of the invention
For above-mentioned demand, invention especially provides a kind of bactericidal agent and preparation method thereof.
Bactericidal agent of the present invention not only has good bactericidal property, and the preparation method of bactericidal agent of the present invention is simple simultaneously, can be widely used in the sterilization of all kinds of article.
Object of the present invention can be achieved through the following technical solutions:
A kind of bactericidal agent, be made up of the component comprising following weight portion:
Hyaluronic acid 8-12 part,
Boron trioxide 1-2 part,
Polylysine 0.5-2 part,
Uncle 16 carbon mercaptan 0.5-1.8 part,
Chitin 0.5-1.5 part,
Ethanol 5-8 part,
Water 65-70 part.
Described component also comprises polythiophene 0-0.08 weight portion.
Described polylysine is epsilon-polylysine.
A preparation method for bactericidal agent, the method comprises the following steps:
(1) polylysine 0.5-2 weight portion, uncle 16 carbon mercaptan 0.5-1.8 weight portion, chitin 0.5-1.5 weight portion and polythiophene 0-0.08 weight portion is taken;
(2) said components is added in homogenizer mix, add hyaluronic acid 8-12 weight portion, ethanol 5-8 weight portion and water 65-70 weight portion successively, in dry nitrogen atmosphere, add diboron trioxide 1-2 weight portion, stir in the closed environment of 85-90 DEG C, obtain bactericidal agent.
Mixing rate in described homogenizer is 1300-1600 rev/min.
Incorporation time in described homogenizer is 2-3 minute.
compared with prior art, its beneficial effect is in the present invention:
(1) bactericidal agent that obtains of the present invention is owing to adding polylysine and uncle 16 carbon mercaptan, the combination of both makes the bactericidal effect of polylysine strengthen, make bactericidal agent of the present invention have good sterilization and fungistatic effect, good sterilization effect can be reached in the short time.
(2) bactericidal agent that obtains of the present invention, its preparation method is simple, is easy to suitability for industrialized production.
Embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1
(1) epsilon-polylysine 0.5kg, uncle 16 carbon mercaptan 0.5kg, chitin 0.5kg and polythiophene 0.08kg is taken;
(2) said components is added in homogenizer mix, add hyaluronic acid 8kg, ethanol 5kg and water 65kg successively, in dry nitrogen atmosphere, add diboron trioxide 1kg, stir in the closed environment of 85 DEG C, obtain bactericidal agent.
The performance test results of obtained bactericidal agent is as shown in table 1.
Embodiment 2
(1) epsilon-polylysine 0.5kg, uncle 16 carbon mercaptan 0.5kg, chitin 0.5kg and polythiophene 0.08kg is taken;
(2) said components is added in homogenizer mix, add hyaluronic acid 8kg, ethanol 5kg and water 65kg successively;
(3) in dry nitrogen atmosphere, add diboron trioxide 1kg, stir in the closed environment of 85 DEG C, obtain bactericidal agent.
The performance test results of obtained bactericidal agent is as shown in table 1.
Embodiment 3
(1) epsilon-polylysine 2kg, uncle 16 carbon mercaptan 0.5kg and chitin 0.5kg is taken;
(2) said components is added in homogenizer mix, add hyaluronic acid 12kg, ethanol 8kg and water 70kg successively;
(3) in dry nitrogen atmosphere, add diboron trioxide 1kg, stir in the closed environment of 90 DEG C, obtain bactericidal agent.
The performance test results of obtained bactericidal agent is as shown in table 1.
Embodiment 4
(1) epsilon-polylysine 0.5kg, uncle 16 carbon mercaptan 1.8kg, chitin 1.5kg and polythiophene 0.08kg is taken;
(2) said components is added in homogenizer mix, add hyaluronic acid 12kg, ethanol 8kg and water 70kg successively;
(3) in dry nitrogen atmosphere, add diboron trioxide 2kg, stir in the closed environment of 90 DEG C, obtain bactericidal agent.
The performance test results of obtained bactericidal agent is as shown in table 1.
Embodiment 5
(1) epsilon-polylysine 1kg, uncle 16 carbon mercaptan 1kg, chitin 1kg and polythiophene 0.04kg is taken;
(2) said components is added in homogenizer mix, add hyaluronic acid 10kg, ethanol 6kg and water 68kg successively;
(3) in dry nitrogen atmosphere, add diboron trioxide 2kg, stir in the closed environment of 88 DEG C, obtain bactericidal agent.
The performance test results of obtained bactericidal agent is as shown in table 1.
Comparative example
Epsilon-polylysine 1kg, ethanol 6kg, titania powder 0.6kg and water 68kg, add high-speed mixer and mixing evenly, obtain bactericidal agent.
Table 1
| Test event | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Comparative example |
| Sterilizing rate | 99.99％ | 99.99％ | 99.99％ | 99.99％ | 99.99％ | 89.31% |
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. a bactericidal agent, is characterized in that, is made up of the component comprising following weight portion:
Hyaluronic acid 8-12 part,
Boron trioxide 1-2 part,
Polylysine 0.5-2 part,
Uncle 16 carbon mercaptan 0.5-1.8 part,
Chitin 0.5-1.5 part,
Ethanol 5-8 part,
Water 65-70 part.
2. bactericidal agent according to claim 1, it is characterized in that, described component also comprises polythiophene 0-0.08 weight portion.
3. bactericidal agent according to claim 1, it is characterized in that, described polylysine is epsilon-polylysine.
4. a preparation method for bactericidal agent, is characterized in that, the method comprises the following steps:
(1) polylysine 0.5-2 weight portion, uncle 16 carbon mercaptan 0.5-1.8 weight portion, chitin 0.5-1.5 weight portion and polythiophene 0-0.08 weight portion is taken;
(2) said components is added in homogenizer mix, add hyaluronic acid 8-12 weight portion, ethanol 5-8 weight portion and water 65-70 weight portion successively, in dry nitrogen atmosphere, add diboron trioxide 1-2 weight portion, stir in the closed environment of 85-90 DEG C, obtain bactericidal agent.
5. the preparation method of bactericidal agent according to claim 4, it is characterized in that, the mixing rate in described homogenizer is 1300-1600 rev/min.
6. the preparation method of bactericidal agent according to claim 4, it is characterized in that, the incorporation time in described homogenizer is 2-3 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510056085.XA CN104663658A (en) | 2015-02-04 | 2015-02-04 | Sterilizing agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510056085.XA CN104663658A (en) | 2015-02-04 | 2015-02-04 | Sterilizing agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104663658A true CN104663658A (en) | 2015-06-03 |
Family
ID=53299667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510056085.XA Pending CN104663658A (en) | 2015-02-04 | 2015-02-04 | Sterilizing agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104663658A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108887287A (en) * | 2018-07-05 | 2018-11-27 | 安徽羽洁家纺有限公司 | A kind of textile Powerful purification bactericidal agent |
| CN111302462A (en) * | 2020-04-16 | 2020-06-19 | 清有生态科技(上海)有限公司 | Tank-making process wastewater pretreating agent and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554181A (en) * | 2008-04-07 | 2009-10-14 | 凯特森生物科技(北京)有限公司 | Chitin thimerosal |
| CN101745139A (en) * | 2010-01-09 | 2010-06-23 | 褚加冕 | Biological antibacterial dressing with sodium hyaluronate |
| CN101822736A (en) * | 2010-03-08 | 2010-09-08 | 深圳市倍安蒂科技有限公司 | Novel biological bactericide and preparation method thereof |
| CN103933064A (en) * | 2014-04-27 | 2014-07-23 | 岳素芝 | Fungus remover |
-
2015
- 2015-02-04 CN CN201510056085.XA patent/CN104663658A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554181A (en) * | 2008-04-07 | 2009-10-14 | 凯特森生物科技(北京)有限公司 | Chitin thimerosal |
| CN101745139A (en) * | 2010-01-09 | 2010-06-23 | 褚加冕 | Biological antibacterial dressing with sodium hyaluronate |
| CN101822736A (en) * | 2010-03-08 | 2010-09-08 | 深圳市倍安蒂科技有限公司 | Novel biological bactericide and preparation method thereof |
| CN103933064A (en) * | 2014-04-27 | 2014-07-23 | 岳素芝 | Fungus remover |
Non-Patent Citations (2)
| Title |
|---|
| 李诚等: "ε－聚赖氨酸抑菌性能研究", 《食品与发酵工业》 * |
| 秦芸桦等: "聚赖氨酸抑菌特性研究", 《安徽农业科学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108887287A (en) * | 2018-07-05 | 2018-11-27 | 安徽羽洁家纺有限公司 | A kind of textile Powerful purification bactericidal agent |
| CN111302462A (en) * | 2020-04-16 | 2020-06-19 | 清有生态科技(上海)有限公司 | Tank-making process wastewater pretreating agent and preparation method thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150603 |
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| RJ01 | Rejection of invention patent application after publication |