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CN104644172A - Method and system for controlling black blood in time-reversal steady state free precession quick imaging sequence - Google Patents

Method and system for controlling black blood in time-reversal steady state free precession quick imaging sequence Download PDF

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CN104644172A
CN104644172A CN201310603946.2A CN201310603946A CN104644172A CN 104644172 A CN104644172 A CN 104644172A CN 201310603946 A CN201310603946 A CN 201310603946A CN 104644172 A CN104644172 A CN 104644172A
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邹超
钟耀祖
刘新
郑海荣
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Shenzhen Institute of Advanced Technology of CAS
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Abstract

本发明涉及一种时间反转稳态进动快速成像序列中黑血的控制方法和系统。所述方法包括:通过时间反转稳态进动快速成像序列扫描成像;扫描中在层选、相位编码和频率编码中至少一个方向上施加预设大小的散相梯度。上述时间反转稳态进动快速成像序列中黑血的控制方法和系统,通过扫描时在层选、相位编码、频率编码中至少一个方向上施加散相梯度,使得在血流速度较慢的区域,提高了血液信号的抑制效果,进而提高了成像图像的质量。

The invention relates to a method and system for controlling black blood in a time-reversal steady-state precession fast imaging sequence. The method includes: scanning and imaging through a time-reversal steady-state precession fast imaging sequence; and applying a dephasing gradient with a preset size in at least one direction of layer selection, phase encoding and frequency encoding during scanning. The method and system for controlling black blood in the above time-reversal steady-state precession fast imaging sequence, by applying a phase gradient in at least one direction of layer selection, phase encoding, and frequency encoding during scanning, makes the The area improves the suppression effect of the blood signal, thereby improving the quality of the imaging image.

Description

时间反转稳态进动快速成像序列中黑血的控制方法和系统Black blood control method and system in time-reversed steady-state precession fast imaging sequence

技术领域technical field

本发明涉及磁共振成像领域,特别是涉及一种时间反转稳态进动快速成像序列中黑血的控制方法和系统。The invention relates to the field of magnetic resonance imaging, in particular to a method and system for controlling black blood in a time-reversal steady-state precession fast imaging sequence.

背景技术Background technique

时间反转稳态进动快速成像序列(Time-reversed Fast Imaging withSteady-state Precession or Contrast Enhanced Fourier Acquired Steady-state,CE-FAST)是一种T2加权(T2WI,T2-weighted imaging,横向弛豫时间加权成像)的梯度回波序列。采用时间反转稳态进动快速成像序列扫描成像时,当血管流速较慢时,血液信号抑制效果较差,即黑血效果较差,导致成像的图像质量较差。Time-reversed Fast Imaging with Steady-state Precession or Contrast Enhanced Fourier Acquired Steady-state (CE-FAST) is a T2-weighted (T2WI, T2-weighted imaging, transverse relaxation time weighted imaging) gradient echo sequence. When the time-reversal steady-state precession fast imaging sequence is used for scanning imaging, when the blood vessel flow rate is slow, the blood signal suppression effect is poor, that is, the black blood effect is poor, resulting in poor image quality.

发明内容Contents of the invention

基于此,有必要针对血管流速较慢时成像的图像质量较差的问题,提供一种能提高成像的图像质量的时间反转稳态进动快速成像序列中黑血的控制方法。Based on this, it is necessary to provide a black blood control method in a time-reversal steady-state precession fast imaging sequence that can improve the imaging image quality for the problem of poor imaging image quality when the blood vessel flow rate is slow.

此外,还有必要提供一种能提高成像的图像质量的时间反转稳态进动快速成像序列中黑血的控制系统。In addition, it is also necessary to provide a control system for black blood in a time-reversal steady-state precession fast imaging sequence that can improve the image quality of the imaging.

一种时间反转稳态进动快速成像序列中黑血的控制方法,包括:A method for the control of black blood in a time-reversal steady-state precession fast imaging sequence comprising:

通过时间反转稳态进动快速成像序列扫描成像;Scanning imaging by time-reversal steady-state precession fast imaging sequence;

扫描中在层选、相位编码和频率编码中至少一个方向上施加预设强度的散相梯度。During scanning, a dephasing gradient with preset intensity is applied in at least one direction of layer selection, phase encoding and frequency encoding.

在其中一个实施例中,所述方法还包括:In one embodiment, the method also includes:

增大所述散相梯度的强度。Increases the strength of the dephasing gradient.

在其中一个实施例中,所述增大所述散相梯度的强度的步骤包括:In one of the embodiments, the step of increasing the intensity of the dephasing gradient comprises:

增大所述散相梯度的幅度或延长所述散相梯度的持续时间。Increasing the magnitude of the dephasing gradient or extending the duration of the dephasing gradient.

在其中一个实施例中,当所述散相梯度施加在层选方向上时,所述散相梯度的预设强度与所述层选的梯度强度成预设比例。In one of the embodiments, when the dephasing gradient is applied in the stratification direction, the preset strength of the dephasing gradient is in a preset ratio to the gradient strength of the stratification.

在其中一个实施例中,所述预设比例为0.2至0.5。In one embodiment, the preset ratio is 0.2 to 0.5.

一种时间反转稳态进动快速成像序列中黑血的控制系统,包括:A control system for black blood in a time-reversed steady-state precession fast imaging sequence comprising:

扫描模块,用于通过时间反转稳态进动快速成像序列扫描成像;Scanning module for scanning imaging by time-reversal steady-state precession fast imaging sequence;

添加模块,用于扫描中在层选、相位编码和频率编码中至少一个方向上施加预设强度的散相梯度。The addition module is used for applying a dephasing gradient with a preset intensity in at least one direction of layer selection, phase encoding and frequency encoding during scanning.

在其中一个实施例中,所述系统还包括:In one of the embodiments, the system also includes:

调控模块,用于增大所述散相梯度的强度。An adjustment module, configured to increase the intensity of the phase gradient.

在其中一个实施例中,所述调控模块还用于增大所述散相梯度的幅度或延长所述散相梯度的持续时间。In one of the embodiments, the regulating module is further configured to increase the magnitude of the dephasing gradient or prolong the duration of the dephasing gradient.

在其中一个实施例中,当所述散相梯度施加在层选方向上时,所述散相梯度的预设强度与所述层选的梯度强度成预设比例。In one of the embodiments, when the dephasing gradient is applied in the stratification direction, the preset strength of the dephasing gradient is in a preset ratio to the gradient strength of the stratification.

在其中一个实施例中,所述预设比例为0.2至0.5。In one embodiment, the preset ratio is 0.2 to 0.5.

上述时间反转稳态进动快速成像序列中黑血的控制方法和系统,通过扫描时在层选、相位编码、频率编码中至少一个方向上施加散相梯度,使得磁共振信号对于流动更加敏感,同时不影响静止器官或对象的信号,提高了血液信号的抑制效果,进而提高了成像图像的质量。The method and system for controlling black blood in the time-reversal steady-state precession fast imaging sequence above apply phase gradients in at least one direction of layer selection, phase encoding, and frequency encoding during scanning, so that the magnetic resonance signal is more sensitive to flow , while not affecting the signals of stationary organs or objects, the suppression effect of blood signals is improved, thereby improving the quality of imaging images.

另外,增大散相梯度的强度可进一步提高控制血流抑制的效果。In addition, increasing the intensity of the dephasing gradient can further improve the effect of controlling blood flow inhibition.

附图说明Description of drawings

图1为一个实施例中一种时间反转稳态进动快速成像序列中黑血的控制方法的流程图;Fig. 1 is a flowchart of a method for controlling black blood in a time-reversal steady-state precession fast imaging sequence in an embodiment;

图2为时间反转稳态进动快速成像序列扫描的时序图;Figure 2 is a timing diagram of time-reversal steady-state precession fast imaging sequence scan;

图3a为不加散相梯度扫描腹部成像图;Figure 3a is the imaging image of abdomen without phase gradient scan;

图3b为加散相梯度扫描腹部成像图;Figure 3b is the image of abdomen with gradient scan with diffuse phase;

图4为一个实施例中时间反转稳态进动快速成像序列中黑血的控制系统的结构框图;Fig. 4 is a structural block diagram of a black blood control system in a time-reversal steady-state precession fast imaging sequence in an embodiment;

图5为另一个实施例中时间反转稳态进动快速成像序列中黑血的控制系统的结构框图;Fig. 5 is a structural block diagram of a black blood control system in a time-reversal steady-state precession fast imaging sequence in another embodiment;

图6为时间反转稳态进动快速成像的装置架构图。Fig. 6 is a device architecture diagram for time-reversal steady-state precession fast imaging.

具体实施方式Detailed ways

为了使本发明的目的、技术方案及优点更加清楚明白,以下结合附图及实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

如图1所示,为一个实施例中一种时间反转稳态进动快速成像序列中黑血的控制方法的流程图。该时间反转稳态进动快速成像序列中黑血的控制方法,包括:As shown in FIG. 1 , it is a flow chart of a method for controlling black blood in a time-reversal steady-state precession fast imaging sequence in an embodiment. The control method of black blood in the time-reversal steady-state precession fast imaging sequence, including:

步骤102,通过时间反转稳态进动快速成像序列扫描成像。Step 102, scanning and imaging through time-reversed steady-state precession fast imaging sequence.

具体的,回波时间是产生磁共振信号回波的时间点。Specifically, the echo time is the time point when the echo of the magnetic resonance signal is generated.

步骤104,扫描中在层选、相位编码和频率编码中至少一个方向上施加预设强度的散相梯度。Step 104, applying a dephasing gradient with a preset intensity in at least one direction of layer selection, phase encoding and frequency encoding during scanning.

如图2所示,为时间反转稳态进动快速成像序列扫描的时序图。采用时间反转稳态进动快速成像序列扫描人体的某区域,如腹部的成像区域,施加周期性的射频脉冲作用于成像区域,使成像区域的磁化矢量达到共振稳态。脉冲之间的重复时间的设置取决于成像区域强度、层厚、信号采集带宽和选择性吸收率等其它因素,为了提高图像的信噪比,应该尽可能取到最小值。层选的梯度用于选择性激发成像中的特定区域,使得射频脉冲仅激发指定位置的质子;相位编码用于对磁共振信号的空间相位进行编码;频率编码用于对磁共振信号的频率进行编码。相位编码和频率编码用于对磁共振信号进行空间编码,标识成像区域中不同位置处采集的磁共振信号,以产生磁共振图像。数据采集用于采集磁共振信号。相位回聚梯度用于抵消相位编码梯度;频率回聚梯度用于抵消频率编码梯度;层选回聚梯度用于抵消层选梯度。层选方向的回聚脉冲放在采集之后,使得自由衰减信号散相,在读出时采集不到该信号,同时自旋回波成分被保留,使得该自旋回波成分可在下一个激发周期内采集得到。As shown in Fig. 2, it is a time sequence diagram of time-reversal steady-state precession fast imaging sequence scanning. A time-reversal steady-state precession fast imaging sequence is used to scan a certain area of the human body, such as the imaging area of the abdomen, and periodic radio frequency pulses are applied to the imaging area to make the magnetization vector of the imaging area reach a resonance steady state. The setting of repetition time between pulses depends on other factors such as imaging area intensity, layer thickness, signal acquisition bandwidth and selective absorption rate. In order to improve the signal-to-noise ratio of the image, the minimum value should be taken as much as possible. The gradient of layer selection is used to selectively excite a specific region in the imaging, so that the radio frequency pulse only excites the protons at the specified position; the phase encoding is used to encode the spatial phase of the magnetic resonance signal; the frequency encoding is used to encode the frequency of the magnetic resonance signal coding. Phase encoding and frequency encoding are used to spatially encode the magnetic resonance signals to identify magnetic resonance signals acquired at different positions in the imaging region to generate magnetic resonance images. Data acquisition is used to acquire magnetic resonance signals. The phase refocusing gradient is used to offset the phase encoding gradient; the frequency refocusing gradient is used to offset the frequency encoding gradient; the layer selection refocusing gradient is used to offset the layer selection gradient. The refocusing pulse in the layer selection direction is placed after the acquisition, so that the free attenuation signal is out of phase, and the signal cannot be acquired during readout, and the spin echo component is retained, so that the spin echo component can be acquired in the next excitation cycle get.

当该散相梯度施加在层选方向上时,该散相梯度的预设强度与该层选的梯度强度成预设比例。该预设比例为0.2至0.5,但不限于此。When the dephasing gradient is applied in the layering direction, the preset strength of the dephasing gradient is in a preset ratio to the gradient strength of the layering. The preset ratio is 0.2 to 0.5, but not limited thereto.

上述时间反转稳态进动快速成像序列中黑血的控制方法,通过扫描时在层选、相位编码、频率编码中至少一个方向上施加散相梯度,使得在血流速度较慢的区域,提高了血液信号的抑制效果,进而提高了成像图像的质量。The method for controlling black blood in the time-reversal steady-state precession rapid imaging sequence above applies a phase gradient in at least one direction of layer selection, phase encoding, and frequency encoding during scanning, so that in areas with slower blood flow, The suppression effect of the blood signal is improved, thereby improving the quality of the imaging image.

图3a为不加散相梯度扫描腹部成像图;图3b为加大散相梯度扫描腹部成像图。图3a中箭头所指的肝脏内血管与腹动脉信号明显高于图3b。Figure 3a is an abdominal imaging image without gradient gradient scan; Figure 3b is an abdominal imaging image with enhanced gradient gradient scan. The signals of blood vessels in the liver and abdominal artery indicated by the arrows in Figure 3a are significantly higher than those in Figure 3b.

在一个实施例中,上述时间反转稳态进动快速成像序列中黑血的控制方法,还包括:增大该散相梯度的强度。增大散相梯度的强度可进一步提高控制血流抑制的效果。In one embodiment, the method for controlling black blood in the time-reversed steady-state precession rapid imaging sequence further includes: increasing the intensity of the dephase gradient. Increasing the intensity of the phase gradient can further improve the effect of controlling blood flow inhibition.

该增大该散相梯度的强度的步骤包括:增大该散相梯度的幅度或延长该散相梯度的持续时间。The step of increasing the intensity of the dephasing gradient includes: increasing the magnitude of the dephasing gradient or prolonging the duration of the dephasing gradient.

如图4所示,一种时间反转稳态进动快速成像序列中黑血的控制系统,包括扫描模块420和添加模块440。其中:As shown in FIG. 4 , a control system for black blood in a time-reversed steady-state precession rapid imaging sequence includes a scanning module 420 and an adding module 440 . in:

扫描模块420用于通过时间反转稳态进动快速成像序列扫描成像。The scanning module 420 is used for scanning imaging through time-reversed steady-state precession fast imaging sequence.

添加模块440,用于扫描中在层选、相位编码和频率编码中至少一个方向上施加预设强度的散相梯度。The adding module 440 is used for applying a dephasing gradient with a preset intensity in at least one direction of layer selection, phase encoding and frequency encoding during scanning.

当该散相梯度施加在层选方向上时,该散相梯度的预设强度与该层选的梯度强度成预设比例。该散相梯度的预设强度与该层选的梯度强度成预设比例。该预设比例为0.2至0.5,但不限于此,具体可根据需要设定。When the dephasing gradient is applied in the layering direction, the preset strength of the dephasing gradient is in a preset ratio to the gradient strength of the layering. The preset strength of the dephase gradient is in a preset ratio to the gradient strength of the slice. The preset ratio is 0.2 to 0.5, but not limited thereto, and can be specifically set as required.

上述时间反转稳态进动快速成像序列中黑血的控制系统,通过扫描时在层选、相位编码、频率编码中至少一个方向上施加散相梯度,使得在血流速度较慢的区域,提高了血液信号的抑制效果,进而提高了成像图像的质量。The black blood control system in the time-reversal steady-state precession fast imaging sequence above applies a phase gradient in at least one direction of layer selection, phase encoding, and frequency encoding during scanning, so that in the area where the blood flow velocity is relatively slow, The suppression effect of the blood signal is improved, thereby improving the quality of the imaging image.

如图5所示,为另一个实施例中时间反转稳态进动快速成像序列中黑血的控制系统的结构框图。该时间反转稳态进动快速成像序列中黑血的控制系统,除了包括扫描模块420和添加模块440,还包括调控模块460。As shown in FIG. 5 , it is a structural block diagram of a black blood control system in a time-reversal steady-state precession fast imaging sequence in another embodiment. The black blood control system in the time-reversal steady-state precession rapid imaging sequence includes a control module 460 in addition to the scanning module 420 and the adding module 440 .

调控模块460用于增大该散相梯度的强度。具体的,该调控模块460还用于增大该散相梯度的幅度或延长该散相梯度的持续时间。The adjustment module 460 is used to increase the intensity of the dephasing gradient. Specifically, the regulating module 460 is also used to increase the magnitude of the phase-out gradient or prolong the duration of the phase-out gradient.

增大散相梯度的强度可进一步提高控制血流抑制的效果。Increasing the intensity of the phase gradient can further improve the effect of controlling blood flow inhibition.

如图6所示,为时间反转稳态进动快速成像的装置架构图。图6中在磁共振防护罩600内设有磁体601、梯度线圈602和射频线圈603,该装置还包括位于磁共振防护罩600外的与梯度线圈604相连的梯度信号放大器605、梯度信号放大器605将检测的梯度信号进行放大得到梯度脉冲序列606,并输送给处理器607进行处理。该装置还包括与射频线圈603相连的射频信号检测器608、与射频信号检测器608相连的数字转换器609、与射频线圈603相连的射频信号放大器610,该数字转换器609与处理器607相连。射频信号放大器610将射频信号放大得到射频脉冲序列611,并将其输送给处理器607进行处理,处理器607对梯度脉冲序列606和射频脉冲序列611进行处理后,通过显示器612进行显示,也可通过打印设备613打印。该时间反转稳态进动快速成像的装置扫描成像时,将病人621平躺在病床620上,让病人621处于射频线圈磁场和梯度线圈磁场中,然后进行扫描。As shown in FIG. 6 , it is a device architecture diagram for fast imaging of time-reversal steady-state precession. In Fig. 6, a magnet 601, a gradient coil 602 and a radio frequency coil 603 are arranged in the magnetic resonance shield 600, and the device also includes a gradient signal amplifier 605 and a gradient signal amplifier 605 connected to the gradient coil 604 outside the magnetic resonance shield 600 The detected gradient signal is amplified to obtain a gradient pulse sequence 606, which is sent to the processor 607 for processing. The device also includes a radio frequency signal detector 608 connected to the radio frequency coil 603, a digital converter 609 connected to the radio frequency signal detector 608, a radio frequency signal amplifier 610 connected to the radio frequency coil 603, and the digital converter 609 is connected to the processor 607 . The radio frequency signal amplifier 610 amplifies the radio frequency signal to obtain a radio frequency pulse sequence 611, and sends it to the processor 607 for processing. After the processor 607 processes the gradient pulse sequence 606 and the radio frequency pulse sequence 611, it is displayed on the display 612. Print by the printing device 613 . When the time-reversed steady-state precession fast imaging device scans and images, the patient 621 is laid flat on the hospital bed 620, and the patient 621 is placed in the magnetic field of the radio frequency coil and the magnetic field of the gradient coil, and then scans.

以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。The above-mentioned embodiments only express several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but should not be construed as limiting the patent scope of the present invention. It should be pointed out that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

Claims (10)

1. the control method of black blood in stable state precession time reversal fast imaging sequences, comprising:
By stable state precession time reversal fast imaging sequences scanning imagery;
At least one direction applies the loose phase gradient of preset strength in scanning in layer choosing, phase code and frequency coding.
2. the control method of black blood in stable state precession time reversal fast imaging sequences according to claim 1, it is characterized in that, described method also comprises:
Increase the intensity of described loose phase gradient.
3. the control method of black blood in stable state precession time reversal fast imaging sequences according to claim 2, it is characterized in that, the step of the intensity of the described loose phase gradient of described increase comprises:
Increase the amplitude of described loose phase gradient or extend the persistent period of described loose phase gradient.
4. the control method of black blood in stable state precession time reversal fast imaging sequences according to claim 1, it is characterized in that, when described loose phase gradient be applied to layer select on direction time, the gradient intensity that preset strength and the described layer of described loose phase gradient select becomes preset ratio.
5. the control method of black blood in stable state precession time reversal fast imaging sequences according to claim 4, it is characterized in that, described preset ratio is 0.2 to 0.5.
6. the control system of black blood in stable state precession time reversal fast imaging sequences, is characterized in that, comprising:
Scan module, for passing through stable state precession time reversal fast imaging sequences scanning imagery;
Add module, in scanning, at least one direction applies the loose phase gradient of preset strength in layer choosing, phase code and frequency coding.
7. the control system of black blood in stable state precession time reversal fast imaging sequences according to claim 6, it is characterized in that, described system also comprises:
Regulation and control module, for increasing the intensity of described loose phase gradient.
8. the control system of black blood in stable state precession time reversal fast imaging sequences according to claim 7, it is characterized in that, described regulation and control module is also for increasing the amplitude of described loose phase gradient or extending the persistent period of described loose phase gradient.
9. the control system of black blood in stable state precession time reversal fast imaging sequences according to claim 6, it is characterized in that, when described loose phase gradient be applied to layer select on direction time, the gradient intensity that preset strength and the described layer of described loose phase gradient select becomes preset ratio.
10. the control system of black blood in stable state precession time reversal fast imaging sequences according to claim 9, it is characterized in that, described preset ratio is 0.2 to 0.5.
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