CN104606724A - Lubricant used for medical catheter and preparation method thereof - Google Patents
Lubricant used for medical catheter and preparation method thereof Download PDFInfo
- Publication number
- CN104606724A CN104606724A CN201510024217.0A CN201510024217A CN104606724A CN 104606724 A CN104606724 A CN 104606724A CN 201510024217 A CN201510024217 A CN 201510024217A CN 104606724 A CN104606724 A CN 104606724A
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- CN
- China
- Prior art keywords
- component
- medical catheter
- weight proportion
- deionized water
- preparation
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- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000000314 lubricant Substances 0.000 title abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 25
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000008367 deionised water Substances 0.000 claims abstract description 22
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 22
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000004202 carbamide Substances 0.000 claims abstract description 11
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 11
- 239000001923 methylcellulose Substances 0.000 claims abstract description 11
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 11
- 239000000306 component Substances 0.000 claims description 40
- 239000002253 acid Substances 0.000 claims description 14
- 229920002401 polyacrylamide Polymers 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 12
- 235000013877 carbamide Nutrition 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 239000012467 final product Substances 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 4
- 239000012895 dilution Substances 0.000 claims description 3
- 238000010790 dilution Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000000576 coating method Methods 0.000 abstract description 12
- 239000011248 coating agent Substances 0.000 abstract description 10
- 239000007787 solid Substances 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 abstract 2
- 239000004925 Acrylic resin Substances 0.000 abstract 1
- 239000005662 Paraffin oil Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000004276 hyalin Anatomy 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000002987 primer (paints) Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The invention provides a preparation method of a lubricant used for a medical catheter. The lubricant used for the medical catheter comprises raw materials in weight proportion as follows: 45-60 parts of a component A, 20-30 parts of a component B, 5-10 parts of polyvinylpyrrolidone and 8-15 parts of acetone, wherein the component A is prepared from raw materials in weight proportion as follows: 20-30 parts of water-borne polyacrylic resin, 55-65 parts of deionized water, 8-10 parts of ethyl alcohol and 3-5 parts of urea; the component B comprises raw materials in weight proportion as follows: 15-20 parts of methylcellulose, 10-30 parts of ethyl alcohol and 50-80 parts of deionized water. The prepared lubricant is hydrophilic and transparent, and is attached to the surface of the medical catheter to form a solid transparent film with the thickness of 0.02-0.05mm. When the catheter is coated with a super-lubricant coating, neither pre-proessing of the surface of the catheter nor addition of a bottom layer on the surface of the catheter is needed, all that is needed is to coat the surface of the catheter when the medical catheter is produced, and accordingly, the lubricant is very convenient to use.
Description
Technical field
The present invention relates to a kind of lubricant, particularly a kind of medical catheter with lubricator, also relates to above-mentioned preparation method.
Background technology
The cleaning of current urethral catheterization treating dysfunction bladder, bladder training etc. are clinical common disease treatment means, and clinical conventional various sterilized catheter carries out intubate.Due to ordinary urethral catheter before use, generally apply one deck paraffin oil at catheter surface; This method application and extensively, but there is many problems, as needed field-applied saxol before (1) clinical manipulation, needing relevant supplementary material, being unfavorable for clinical manipulation; (2) paraffin oil is in catheter surface poor adhesive force, has lubricant effect during insertion, does not substantially have lubrication when extracting, and causes a lot of misery to patient; (3) paraffin oil is oily lubricant, and cleaning is also inconvenient.In addition, also have other kind hydrophilic lubricant in the market, some chance water is muddy, has irritant reaction to tissue adherence; Have apply with conduit time, complex process, in order to strengthen and catheter surface firmness, often need conduit pretreatment and adding the situations such as primer coating.
Summary of the invention
Technical problem to be solved by this invention is for the deficiencies in the prior art, and provide a kind of method simple, the medical catheter of high lubricating effect with lubricator.
Another technical problem to be solved by this invention there is provided the preparation method of above-mentioned lubricant.
Technical problem to be solved by this invention is realized by following technical scheme, the present invention be a kind of medical catheter with lubricator, be characterized in, it is made up of the raw material of following weight proportion:
Component A 45-60, B component 20-30, polyvinylpyrrolidone 5-10, acetone 8-15;
Described component A is made up of the raw material of following weight proportion: aqueous polyacrylamide acid resin 20-30, deionized water 55-65, ethanol 8-10, carbamide 3-5;
Described B component is made up of the raw material of following weight proportion: methylcellulose 15-20, ethanol 10-30, deionized water 50-80.
With lubricator, to medical catheter of the present invention it be made up of the raw material of following weight proportion: component A 52, B component 25, polyvinylpyrrolidone 8, acetone 12.
Medical catheter of the present invention with lubricator, be made up of the raw material of following weight proportion by described component A: aqueous polyacrylamide acid resin 25, deionized water 60, ethanol 9, carbamide 4;
Described B component is made up of the raw material of following weight proportion: methylcellulose 18, ethanol 20, deionized water 65.
The invention also discloses a kind of medical catheter as described in above scheme preparation method with lubricator, be characterized in, by weight taking component A, B component, polyvinylpyrrolidone and acetone respectively, mixing and stirring, then, after airtight standing 20-30 hour, product is obtained.
In medical catheter of the present invention preparation method with lubricator, the preparation method of described component A is, its step is as follows: by deionized water, ethanol and carbamide mix homogeneously, after join in agitator, slowly add aqueous polyacrylamide acid resin while stirring, at 50-70 DEG C of temperature stir until aqueous polyacrylamide acid resin all dissolves, after be cooled to room temperature, to obtain final product.
In medical catheter of the present invention preparation method with lubricator, the preparation method of described B component is that its step is as follows: methylcellulose and ethanol mix and blend are formed turbid solution, after add deionized water and carry out dilution stirring until solution is limpid, to obtain final product.
Aqueous polyacrylamide acid resin of the present invention is that any one commercially available in prior art is applicable to produce lubricant.Such as: Hua Jinsi company limited of the U.S.; Address: Chinese Shanghai Jing'an District China. Room 1503, No. 1, Lane 1135, Wuding County road, Jing'an District, Shanghai; Phone: 86-021-62329851, the Hua Jinsi Hd2535 of production.
Compared with prior art, the lubricant that the present invention obtains is hydrophilic lubricant, transparent shape, can form the solid transparent film of 2-5 silk in medical catheter surface attachment.Surface with this coating medical catheter before use, flood 5-10 second in water after, catheter surface still keeps transparence; But its surface is extremely lubricated, its coefficient of friction will be reduced to 80-100 doubly, greatly reduce the misery of patient, without allergy when this lubricant contacts with tissue, have good biocompatibility.During this superslide coating coating conduit, do not need catheter surface pretreatment, do not need to add bottom at catheter surface yet, only need in its surface-coated when producing medical catheter, therefore very easy to use.
Detailed description of the invention
Below further describe concrete technical scheme of the present invention, so that those skilled in the art understands the present invention further, and do not form the restriction to its right.
Embodiment 1, a kind of medical catheter preparation method with lubricator, its step is as follows: it is made up of the raw material of following weight proportion:
Component A 45, B component 20, polyvinylpyrrolidone 5, acetone 8;
Described component A is made up of the raw material of following weight proportion: aqueous polyacrylamide acid resin 20, deionized water 55, ethanol 8, carbamide 3;
Described B component is made up of the raw material of following weight proportion: methylcellulose 15, ethanol 10, deionized water 50.
Embodiment 2, a kind of medical catheter preparation method with lubricator, its step is as follows: it is made up of the raw material of following weight proportion:
Component A 60, B component 30, polyvinylpyrrolidone 10, acetone 15;
Described component A is made up of the raw material of following weight proportion: aqueous polyacrylamide acid resin 30, deionized water 65, ethanol 10, carbamide 5;
Described B component is made up of the raw material of following weight proportion: methylcellulose 20, ethanol 30, deionized water 80.
Embodiment 3, a kind of medical catheter preparation method with lubricator, its step is as follows: it is made up of the raw material of following weight proportion:
Component A 52, B component 25, polyvinylpyrrolidone 8, acetone 12;
Described component A is made up of the raw material of following weight proportion: aqueous polyacrylamide acid resin 25, deionized water 60, ethanol 9, carbamide 4;
Described B component is made up of the raw material of following weight proportion: methylcellulose 18, ethanol 20, deionized water 65.
Embodiment 4, a kind of medical catheter as described in any one of embodiment 1-3 preparation method with lubricator, by weight taking component A, B component, polyvinylpyrrolidone and acetone respectively, mixing and stirring, then airtight standing after 25 hours, obtain product.
Embodiment 5, medical catheter according to embodiment 4 preparation method with lubricator, the preparation method of described component A is, its step is as follows: by deionized water, ethanol and carbamide mix homogeneously, after join in agitator, slowly add aqueous polyacrylamide acid resin while stirring, at 60 DEG C of temperature stir until aqueous polyacrylamide acid resin all dissolves, after be cooled to room temperature, to obtain final product.
Embodiment 6, medical catheter according to embodiment 4 preparation method with lubricator, the preparation method of described B component is that its step is as follows: methylcellulose and ethanol mix and blend are formed turbid solution, after add deionized water carry out dilution stir until solution is limpid, to obtain final product.
During this superslide coating coating conduit, do not need can reach desirable firmness to catheter surface pretreatment.When producing medical catheter, during with this superslide coating coating conduit, do not need to add bottom at catheter surface, only need apply one deck as superslide layer, both improve productivity effect, greatly improve product quality simultaneously yet.
This superslide coating is hydrophilic lubricant, all presents pellucidity with before and after water retting, catheter surface coefficient of friction can be made to reduce 80-100 doubly, greatly reduce the misery of patient after meeting water.This superslide coatings applications, on the medical catheter surface of making for raw material with PVC, latex and silica gel, all can form the firm hyaline membrane of one deck 2-5 silk.During the conduit of Clinical practice with this coating, extremely convenient, do not need other auxiliary equipment, before using, only conduit need be soaked water, conduit soft durometer can be regulated according to water temperature simultaneously.Many convenience are brought to clinical.This superslide coatings applications, at catheter surface, after testing, without allergy when contacting with tissue, has good biocompatibility.
Claims (6)
1. a medical catheter with lubricator, is characterized in that, it is made up of the raw material of following weight proportion:
Component A 45-60, B component 20-30, polyvinylpyrrolidone 5-10, acetone 8-15;
Described component A is made up of the raw material of following weight proportion: aqueous polyacrylamide acid resin 20-30, deionized water 55-65, ethanol 8-10, carbamide 3-5;
Described B component is made up of the raw material of following weight proportion: methylcellulose 15-20, ethanol 10-30, deionized water 50-80.
2. medical catheter according to claim 1 with lubricator, is characterized in that, it is made up of the raw material of following weight proportion: component A 52, B component 25, polyvinylpyrrolidone 8, acetone 12.
3. medical catheter according to claim 1 with lubricator, is characterized in that, described component A is made up of the raw material of following weight proportion: aqueous polyacrylamide acid resin 25, deionized water 60, ethanol 9, carbamide 4;
Described B component is made up of the raw material of following weight proportion: methylcellulose 18, ethanol 20, deionized water 65.
4. the medical catheter preparation method with lubricator as described in claim 1 or 2 or 3, it is characterized in that, by weight taking component A, B component, polyvinylpyrrolidone and acetone respectively, mixing and stirring, then, after airtight standing 20-30 hour, product is obtained.
5. medical catheter according to claim 4 preparation method with lubricator, it is characterized in that, the preparation method of described component A is, its step is as follows: by deionized water, ethanol and carbamide mix homogeneously, after join in agitator, slowly add aqueous polyacrylamide acid resin while stirring, at 50-70 DEG C of temperature stir until aqueous polyacrylamide acid resin all dissolves, after be cooled to room temperature, to obtain final product.
6. medical catheter according to claim 4 preparation method with lubricator, it is characterized in that, the preparation method of described B component is that its step is as follows: methylcellulose and ethanol mix and blend are formed turbid solution, after add deionized water carry out dilution stir until solution is limpid, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510024217.0A CN104606724A (en) | 2015-01-19 | 2015-01-19 | Lubricant used for medical catheter and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510024217.0A CN104606724A (en) | 2015-01-19 | 2015-01-19 | Lubricant used for medical catheter and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104606724A true CN104606724A (en) | 2015-05-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510024217.0A Pending CN104606724A (en) | 2015-01-19 | 2015-01-19 | Lubricant used for medical catheter and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104606724A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010051669A1 (en) * | 1998-10-07 | 2001-12-13 | Mcghee Diane | Lubricious coating |
| CN101035573A (en) * | 2004-10-07 | 2007-09-12 | 科洛普拉斯特公司 | A medical device having a wetted hydrophilic coating |
| WO2008151074A1 (en) * | 2007-05-30 | 2008-12-11 | Applied Medical Resources Corporation | Lubricant for medical devices |
| CN101619191A (en) * | 2009-08-07 | 2010-01-06 | 西安大天科技股份有限公司 | Water-soluble transfer aluminium-plating coating and preparation method thereof |
| CN101730528A (en) * | 2007-06-26 | 2010-06-09 | 药品配送方案有限公司 | A bioerodible patch |
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN102973987A (en) * | 2012-12-10 | 2013-03-20 | 宁波保税区安杰脉德医疗器械有限公司 | Medical hydrophilic lubrication coating of water system and preparation method thereof |
-
2015
- 2015-01-19 CN CN201510024217.0A patent/CN104606724A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010051669A1 (en) * | 1998-10-07 | 2001-12-13 | Mcghee Diane | Lubricious coating |
| CN101035573A (en) * | 2004-10-07 | 2007-09-12 | 科洛普拉斯特公司 | A medical device having a wetted hydrophilic coating |
| WO2008151074A1 (en) * | 2007-05-30 | 2008-12-11 | Applied Medical Resources Corporation | Lubricant for medical devices |
| CN101730528A (en) * | 2007-06-26 | 2010-06-09 | 药品配送方案有限公司 | A bioerodible patch |
| CN101619191A (en) * | 2009-08-07 | 2010-01-06 | 西安大天科技股份有限公司 | Water-soluble transfer aluminium-plating coating and preparation method thereof |
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN102973987A (en) * | 2012-12-10 | 2013-03-20 | 宁波保税区安杰脉德医疗器械有限公司 | Medical hydrophilic lubrication coating of water system and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150513 |