CN104606204A - Febrifuge for children - Google Patents

Abstract

The invention belongs to the technical field of medicine, and in particular relates to an antipyretic for children, which consists of the following components by weight: 0.5-3 parts of dexamethasone, 8-25 parts of dipyridamole, 50-150 parts of Qutong Tablets, and 10,000 parts of normal saline -20,000 copies; dipyridamole of the present invention has the function of dilating blood vessels, blood vessels dilate, and blood flow speed increases, which is beneficial to heat dissipation; dexamethasone has anti-inflammatory, anti-viral, anti-shock, and anti-allergic effects; Qutong Tablets can be withdrawn heat and relieve mild and moderate pain, the three effective components of the present invention are used in combination to play a synergistic role, and overcome their respective defects. Those with persistent high fever can reduce their fever after using it once or twice, and can achieve sustained Antipyretic effect.

Description

antipyretics for children

technical field

The invention belongs to the technical field of medicine, and in particular relates to an antipyretic for children.

Background technique

High fever is a common disease in children, often difficult to control, and prone to recurrent high fever. Generally, antipyretics are used for control, and the dosage forms of antipyretics mainly include oral medicines, injections, and patches.

(1) Oral medicine: Children often have difficulty swallowing oral medicine.

(2) Injection: Children's blood vessels are small and difficult to puncture, and children are active, which may easily lead to puncture failure, cause congestion, and bring pain to children.

(3) Patch: The skin absorbs the patch slowly and cools down slowly, so it cannot be used for rapid cooling of high fever.

Antipyretics are medicines that can dilate blood vessels on the human body surface by regulating human body functions, and then increase heat dissipation through processes such as sweating, while suppressing chills and reducing body heat production. It can effectively control fever and lower body temperature, but it cannot fundamentally eliminate the cause of fever. Fever is one of the common symptoms of many diseases. It is not acceptable to use antipyretics to treat fever regardless of the etiology and condition. Antipyretics have toxic side effects.

Antipyretics are commonly used, but their toxic side effects are also common. Such as drug eruption, gastrointestinal tract reaction, blood system reaction and damage to liver and kidney function, etc., especially when such drugs are used for a long time or excessively, the toxic and side effects are more significant.

Common pediatric antipyretics currently on the market include the following:

1. Acetaminophen is a safe antipyretic drug. Its antipyretic effect is directly proportional to the dosage, but excessive dosage can cause damage to liver and kidney function. The dose is 10-15 mg per kg body weight, once every 4-6 hours. Representative drugs such as Tylenol, Xiaoerbaifuning drops and so on.

2. Bupleurum Injection: It is an injection extracted from the traditional Chinese medicine Bupleurum. The antipyretic effect of this medicine is slow and weak, and there are few side effects. However, it should be noted that children with allergies should use it with caution.

3. Ibuprofen: It is a non-steroidal anti-inflammatory drug, which has obvious antipyretic and analgesic effects, and has few side effects. This product can replace intramuscular injection of antipyretic drugs, and is suitable for children with high fever caused by infectious diseases. The dose is 5-10 mg per kg body weight, once every 6-8 hours. The representative medicines are Torn Oral Solution and Pediatric Merrill Syrup.

4. Antongding, also known as compound aminopyrine, is the most commonly used antipyretic drug in clinical practice. However, repeated injections of this product in a short period of time can easily cause acute agranulocytosis, which is fatal. For some For children, this drug has side effects such as inducing acute hemolytic anemia and skin rash. In addition, if the dose of this product is injected too much, the child will sweat excessively, and the body temperature will drop suddenly, which will easily cause collapse. Disabled, use with caution in older children.

5. Analgin: The main side effects are nephrotoxicity, gastrointestinal bleeding, and severe skin rash, and fatal agranulocytosis is the most serious side effect. At present, many countries prohibit or restrict the use of this product, but some local hospitals in China still use it, which deserves great attention.

6. Aspirin: This is an antipyretic with a long history. It has a strong antipyretic effect, but it has a lot of side effects. At present, it is tending to be eliminated in domestic pediatrics.

7. Antipyretic drugs of Chinese patent medicines.

Contents of the invention

The technical problem to be solved by the present invention is to provide an antipyretic medicine for children, which has fast antipyretic effect, less toxic and side effects, and can achieve continuous antipyretic effect.

In order to solve the problems of the technologies described above, content of the present invention is made up of following weight components:

Dexamethasone 0.5-3 parts,

Persantine 8-25 parts,

Qu Pain Tablets 50-150 copies,

10,000-20,000 parts of normal saline.

Preferably, the antipyretic for children consists of the following components by weight:

1-2 parts of dexamethasone,

Persantine 12.5-20 parts,

75-125 servings of Pain Relief Tablets,

10,000-15,000 copies of normal saline.

Most preferably, the antipyretic for children consists of the following components by weight:

1.5 parts of dexamethasone,

16 parts of dipyridamole,

100 copies of Pain Relief Tablets,

10,000 parts of normal saline.

The dexamethasone of the present invention, also known as Dexamethasone and Flumeprednisolone, are anti-inflammatory and anti-allergic drugs. It is mainly used as emergency medicine for critical illness and treatment of various inflammations. The pharmacological effects are mainly anti-inflammatory, anti-toxic, anti-allergic, anti-rheumatic, and are widely used clinically. When used to reduce fever, it can inhibit the release of pyrogens, reduce the sensitivity of the body temperature center, and is easily absorbed from the digestive tract. It has the following functions: anti-inflammatory and immunosuppressive effects.

Common side effects of dexamethasone include the following:

1. Long-term use can cause the following side effects: iatrogenic Cushing syndrome appearance and posture, weight gain, lower extremity edema, purple streaks, easy bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humerus or femoral head, bone osteoporosis and fractures, muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation, pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataract, benign intracranial hypertension syndrome, diabetes Impaired tolerance and exacerbation of diabetes.

2. Patients may present with psychiatric symptoms: euphoria, agitation, delirium, restlessness, disorientation, and depression. Mental symptoms are prone to occur with people suffering from chronic wasting diseases and those who have had mental disorders in the past.

3. Concurrent infection is the main adverse reaction of adrenocortical hormone.

4. Glucocorticoid withdrawal syndrome.

Dexamethasone is used to cool down high fever, but there are complications, such as reducing the body's immune function, hindering the formation of antibodies, causing some pathogenic bacteria to take advantage of the opportunity to grow and reproduce, causing secondary infections or certain inflammatory diseases, etc. The body temperature suddenly drops and a large number of Sweating can easily cause collapse.

Dipyridamole of the present invention, alias dipyridamole, dipyridamole (Dipyridamole), dipyridamole, is a non-nitrate coronary artery dilator, which has the functions of dilating coronary blood vessels, promoting the formation of collateral circulation and mild Anticoagulant effect. Dipyridamole has an antiviral effect, by inhibiting the entry of dioxypyrimidine nucleosides into FL cells through the cell membrane, and selectively inhibiting the synthesis of viral PNA, thereby completely inhibiting the virus-specific proliferation process. Its common side effects are fatigue, headache, dizziness, fainting, vomiting, diarrhea, flushing, rash, itching and gastrointestinal discomfort, etc. It is usually considered that this product cannot be mixed with other drugs for injection in clinical practice.

Dipyridamole is generally not used for reducing fever, and it can only reduce temperature when used for reducing fever, but it is accompanied by complications, such as fatigue, headache, dizziness, fainting, gastrointestinal discomfort, tonsillitis, bronchitis, bronchopneumonia, etc.

The Qutong tablet of the present invention is a compound preparation, and its components are as follows: each tablet is composed of 150 mg of aminopyrine, 150 mg of phenacetin, 50 mg of caffeine and 15 mg of phenobarbital. Qutong tablets need to be avoided in combination with other non-steroidal anti-inflammatory drugs, including selective COX-2 inhibitors, because gastrointestinal bleeding, Adverse effects of ulceration and perforation, the risk of which can be fatal.

Qutong tablets can be used to cool down high fever, and at the same time have a sedative effect, which is beneficial for children to rest. It is generally not used to reduce fever. When it is used to reduce fever, it will cause side effects of the digestive system, such as indigestion, nausea and vomiting, and skin reactions such as rash and itching.

The physiological saline in the present invention is a sodium chloride solution with a weight concentration of 0.85-0.9%.

The beneficial effects of the present invention are that dipyridamole of the present invention has the function of dilating blood vessels, blood vessels dilate, and blood flow speed increases, which is beneficial to heat dissipation; dexamethasone has anti-inflammatory, anti-viral, anti-shock, and anti-allergic effects; It can reduce fever and relieve mild and moderate pain, and has a sedative effect. The three effective components are used in combination to play a synergistic role, and overcome their respective defects. People with persistent high fever can reduce fever after using it once or twice, and can achieve the effect of continuous fever reduction.

Detailed ways

Example 1

The antipyretic medicine for children of the present invention is composed of 1.5 mg of dexamethasone, 16 mg of dipyridamole, 100 mg of Qutong tablets and 10 ml of normal saline. The preparation method is that the dexamethasone, dipyridamole and Qutong tablets are ground and pulverized, and dissolved in physiological saline.

Example 2

The antipyretic medicine for children of the present invention is composed of 1 mg of dexamethasone, 20 mg of dipyridamole, 75 mg of Qutong tablets and 15 ml of normal saline. The preparation method is the same as in Example 1.

Example 3

The antipyretic medicine for children of the present invention is composed of 2 mg of dexamethasone, 12.5 mg of dipyridamole, 125 mg of Qutong tablets and 10 ml of normal saline. The preparation method is the same as in Example 1.

Example 4

The antipyretic medicine for children of the present invention is composed of 0.5 mg of dexamethasone, 25 mg of dipyridamole, 50 mg of Qutong tablets and 10 ml of normal saline. The preparation method is the same as in Example 1.

Example 5

The antipyretic medicine for children of the present invention is composed of 3 mg of dexamethasone, 8 mg of dipyridamole, 150 mg of Qutong tablets and 20 ml of normal saline. The preparation method is the same as in Example 1.

Example 6

The method of use is as follows: use a syringe to introduce the antipyretic medicine for children obtained in any one of Examples 1-5 into the rectum through the anus of the child.

Example 7

The method of use is as follows: the children's antipyretic medicine obtained in any one of Examples 1-5 is introduced into the rectum through the children's anus by using a disposable anal canal.

Example 8

Effect description

For 78 cases of high fever patients, in January 2015, in the outpatient department of the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine, the antipyretic medicine for children prepared in Example 1 was used according to the method of Example 7, and it was found that 75 cases of high fever children returned to normal after use. The rate reached 96.15%. The main manifestations of high fever are: body temperature is between 39.1-40°C, high fever persists or high fever is repeated; the main symptoms of high fever children returning to normal are: body temperature is between 36.5-37.5°C, there will be no rebound of high fever, and once The duration of cooling after administration is about 18-24 hours. If the child's body temperature is between 36.5-37.5 ℃, it means that the fever has been successfully reduced. If the high fever rebounds after 18-24 hours, it means that the fever has failed. Fever due to other causes (such as mycoplasma infection, etc.) needs to be considered, and blood cultures should be used to determine the etiology.

Example 9

Comparative test analysis

Design comparative test, namely dexamethasone, dipyridamole, Qutong Tablets, Tylenol and ibuprofen oral suspension are used alone, and the medicine of Example 1 of the present invention is used to reduce fever in children, carry out comparative analysis, and observe its curative effect , to observe the fever-reducing time and duration of the children's fever after the first medication, and the fever-reducing results and adverse reactions of the entire treatment cycle. The specific results are shown in Table 1.

Table 1 The effect of different drugs on fever reduction in patients with high fever

The dosages of dexamethasone, dipyridamole, and Qutong tablets are used according to their usual dosages for reducing fever. Among them, the dosage of dexamethasone is 2mg dexamethasone dissolved in 10ml normal saline; the dosage of dipyridamole is 20mg dissolved in 10ml normal saline; Co., Ltd.), ibuprofen oral suspension (Tianda Pharmaceutical (Zhuhai) Co., Ltd.) according to its instructions.

Refer to the description of Example 8 for the characterization of successful and failed fever reduction.

The 2 cases of adverse reactions of dexamethasone were characterized by a sudden drop in body temperature and profuse sweating, causing collapse (rapid heartbeat, shortness of breath, shortness of breath, chest tightness, fainting). And nausea, vomiting, acid reflux, loss of appetite phenomenon.

The adverse reactions of dipyridamole in 3 cases were characterized by fatigue, headache, dizziness, fainting, and gastrointestinal discomfort, among which 1 case was accompanied by tonsillitis and 1 case was accompanied by bronchitis.

Two cases of adverse reactions of Qutong Tablets were characterized by indigestion, nausea and vomiting, and one case was accompanied by rash and itching.

Tylenol adverse reactions are characterized by rash.

Adverse reactions of ibuprofen oral suspension are characterized by dyspepsia and rash.

As can be seen from the data in Table 1, compared with the use of dexamethasone, dipyridamole and Qutong Tablets to reduce fever in children, after the medicine of Example 1 of the present invention is used to reduce fever in children, the fever reduction time is short, the duration is long, and the fever reduction is successful. The probability is higher, and the probability of adverse reactions is smaller. The chi-square value and p-value indicate that there is a significant difference in the probability of successful fever reduction of each drug, and there is also a significant difference in the probability of adverse reactions. Even compared with the use of Tylenol and ibuprofen oral suspension to reduce fever in children, the medicine of the present invention has a high success rate in reducing fever in children and has less adverse reactions.

Those of ordinary skill in the art should understand that: the above descriptions are only specific embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principles of the present invention etc., should be included within the protection scope of the present invention.

Claims (3)

1. child's febrifuge, is characterized in that, is made up of following components by weight percent:

Dexamethasone 0.5-3 part,

Persantin 8-25 part,

Somedon 50-150 part,

Normal saline 10,000-2 ten thousand parts.

2. child's febrifuge as claimed in claim 1, it is characterized in that, described child's febrifuge is made up of following components by weight percent:

Dexamethasone 1-2 part,

Persantin 12.5-20 part,

Somedon 75-125 part,

Normal saline 10,000-1.5 ten thousand parts.

3. child's febrifuge as claimed in claim 1 or 2, it is characterized in that, described child's febrifuge is made up of following components by weight percent:

Dexamethasone 1.5 parts,

Persantin 16 parts,

Somedon 100 parts,

Normal saline 10,000 parts.