CN104586676A - Plant formula for preventing and treating black eye and edema around eyes caused by staying-up all night and its preparation method and use - Google Patents
Plant formula for preventing and treating black eye and edema around eyes caused by staying-up all night and its preparation method and use Download PDFInfo
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- CN104586676A CN104586676A CN201410453871.9A CN201410453871A CN104586676A CN 104586676 A CN104586676 A CN 104586676A CN 201410453871 A CN201410453871 A CN 201410453871A CN 104586676 A CN104586676 A CN 104586676A
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- 241000544230 Dioscorea communis Species 0.000 title claims abstract description 21
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- 208000035753 Periorbital contusion Diseases 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 230000000694 effects Effects 0.000 claims abstract description 22
- 235000008995 european elder Nutrition 0.000 claims abstract description 7
- 244000223141 Leucojum aestivum Species 0.000 claims abstract description 6
- 240000006028 Sambucus nigra Species 0.000 claims abstract description 6
- 235000003142 Sambucus nigra Nutrition 0.000 claims abstract description 6
- 230000002087 whitening effect Effects 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 244000230712 Narcissus tazetta Species 0.000 claims description 5
- 241000208181 Pelargonium Species 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000003480 eluent Substances 0.000 claims description 4
- 238000007654 immersion Methods 0.000 claims description 4
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- 229920005989 resin Polymers 0.000 claims description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 239000000419 plant extract Substances 0.000 claims description 3
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 229960004697 enzacamene Drugs 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 230000000474 nursing effect Effects 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- 238000009418 renovation Methods 0.000 claims description 2
- 235000010265 sodium sulphite Nutrition 0.000 claims description 2
- 230000000475 sunscreen effect Effects 0.000 claims description 2
- 239000000516 sunscreening agent Substances 0.000 claims description 2
- 230000004089 microcirculation Effects 0.000 abstract description 9
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 8
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
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- 241000234479 Narcissus Species 0.000 abstract 1
- 241000219925 Oenothera Species 0.000 abstract 1
- 235000004496 Oenothera biennis Nutrition 0.000 abstract 1
- 244000270673 Pelargonium graveolens Species 0.000 abstract 1
- 235000017927 Pelargonium graveolens Nutrition 0.000 abstract 1
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- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 2
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- KQROHCSYOGBQGJ-UHFFFAOYSA-N 5-Hydroxytryptophol Chemical compound C1=C(O)C=C2C(CCO)=CNC2=C1 KQROHCSYOGBQGJ-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a plant formula for preventing and treating black eye and edema around eyes caused by staying-up all night and its preparation method and use. The plant formula comprises, by weight, 1-20% of pelargonium graveolens, 10-30% of evening primrose, 10-40% of Leucojum aestivum bulb, 10-40% of narcissus bulb and 1-20% of Sambucus nigra Elder flower. The invention provides a use of the plant formula in products with effects of whitening and caring skin and eyes. Compared with the same type of the existing products, the plant formula has obvious dual functions of inhibiting melanin and promoting microcirculation and has good safety.
Description
Technical field
The present invention relates to eye cream field, particularly relate to and a kind ofly there is control to stay up late the eye cream of the black eye that cause and edema effect near the eyes.
Background technology
Because social competition is day by day fierce, live and work tempo increase, staying up late is the recurrent thing of modern, through often there is black eye and edema near the eyes after staying up late, all can bring unfavorable factor to the outward appearance of eye health and people.Prove through modern scientific research, the black eye occurred after staying up late and near the eyes edema are mainly due to result that microcirculation disturbance near the eyes causes the delay of partial water liquid and melanin deposition to be formed.And there is the indefinite problem with there is certain untoward reaction of effect in the eye cosmetic great majority adopted at present.
Along with growth in the living standard and human sciences's accumulation of knowledge, people have a very large change for the requirement of eye maintenance face cosmetics.
Eye maintenance product effect conventional is at present not ideal enough.So people be starved of there is definite effect, act on by way of various, safely, the control that has that has no adverse reaction stays up late the product of the black eye that cause and edema effect near the eyes.
Summary of the invention
One object of the present invention be to find one have multiple effect by way of, control can be had and to stay up late the plant prescription of the black eye that cause and edema effect near the eyes.
Described have control and to stay up late the plant prescription of the black eye that cause and edema effect near the eyes, comprises following composition by weight percentage: Pelargonium gravelens 1 ~ 20%, Radix Oenotherae erythrosepalae 10 ~ 30%, leucojum aestivum bulb 10 ~ 40%, Narcissus Tazetta L. Var 10 ~ 40%, flower of Sambucus nigra L. 1 ~ 20%.
Above-mentioned have control and to stay up late the preparation method of plant prescription of the black eye that cause and edema effect near the eyes, comprises the steps:
(1) by above-mentioned plant prescription with 20% ~ 80% alcohol-pickled, the ethanol consumption (weight) soaked is prescription plant weight 20 ~ 300 times, and soak time is 2 ~ 48 hours;
(2) solution after above-mentioned immersion is concentrated 10 ~ 50 times after filtering, then by macroporous resin on concentrated solution, with the ethanol eluting of 10% ~ 98%, collect eluent.
Filtration in described step 2 200 object strainer filterings.
Another object of the present invention is to provide the application of described plant prescription before whitening, skin nursing in eye maintenance product
There is control as claimed in claim 1 to stay up late the skin whitener of plant prescription of the black eye that cause and edema effect near the eyes, comprise following composition by weight percentage: A phase component: 4 methyl benzylidene camphor
1 ~ 5%, OctMet 2 ~ 7%, butyl methoxydibenzoylmethise 1 ~ 3%, 16,18 alcohol 2 ~ 4%, dimension E acetate 1 ~ 3%, fragrantly quickly relax 0.1 ~ 1%, cetearyl ether-201 ~ 2%, C12-15 benzoate 2 ~ 6%, renovation agent 1 ~ 4%, 1,2,6 ditertiary butyl p cresol 0.05 ~ 0.1%, propyl p-hydroxybenzoate 0.1 ~ 0.2%; B phase component: HANSHENGJIAO 0.2 ~ 0.3%, disodiumedetate 0.1 ~ 0.2%, methyl parahydroxybenzoate 0.2 ~ 0.3%, potassium cetyl phosphate 1 ~ 2%, sodium sulfite 0.05 ~ 0.2%, remaining ingredient are deionized water; C phase component: sunscreen 1 ~ 4%; D phase component: polyacrylamide 1 ~ 3%; E phase component: essence 0.01 ~ 0.3%; Plant extract formula 5-10%; Antiseptic 0.1 ~ 0.5%, citric acid 0.1 ~ 2%.
Above-mentioned have control and to stay up late the preparation method of skin whitener of plant prescription of the black eye that cause and edema effect near the eyes, comprises the steps:
(1) first HANSHENGJIAO is dispersed in water, and increases the temperature to 80 degree simultaneously, then add other components of B phase, stir;
(2) A phase is dissolved completely in 80 degree, stir;
(3) be added to by A in B phase and stir homogenizing (about 4 minutes), add C phase rapid stirring after homogenizing 1,2 minutes, froth breaking is cooled to 65 degree;
(4) then add D phase, add E phase to 40 degree after stirring, stir discharging, and pH value controls at 4.0-5.0.
The present invention has successful compared with existing like product, have check melanin and promote microcirculatory dual function and the good feature of safety.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below the present invention is described in further detail.
In the good technical scheme of the present invention, the proportioning of prescription E-dream5 is as follows: (weight ratio) Pelargonium gravelens 3 ~ 15%, Radix Oenotherae erythrosepalae 15 ~ 25%, leucojum aestivum bulb 15 ~ 30%, Narcissus Tazetta L. Var 15 ~ 30%, flower of Sambucus nigra L. 3 ~ 15%.
Plant society E-dream5 of the present invention can be used for preparing and has the stay up late external eye such as cream, emulsion, astringent, gel, facial film, inuncts, lotion of the black eye that cause and edema effect near the eyes of control and maintain product, be mix mutually with the substrate of known cosmetics and medicine or adjuvant, carrier, additive, be conventionally prepared.
Below by implementation column, elaboration detailed is further done to the present invention.
Embodiment 1
At room temperature, get Pelargonium gravelens 10 kilograms, Radix Oenotherae erythrosepalae 25 kilograms, 25 kilograms, leucojum aestivum bulb, Narcissus Tazetta L. Var 30 kilograms, flower of Sambucus nigra L. 10 kilograms, ethanol with 50% 1200 kilograms of soak times are 24 hours, residue soaks 24 hours with the ethanol 1200 kilograms of 50% again, then the solution after immersion is merged, after 200 object strainer filterings, concentrate 20 times, then go up macroporous resin, with 40% ethanol eluting, collect eluent.
Embodiment 2
At room temperature, get Pelargonium gravelens 5 kilograms, Radix Oenotherae erythrosepalae 25 kilograms, 30 kilograms, leucojum aestivum bulb, Narcissus Tazetta L. Var 25 kilograms, flower of Sambucus nigra L. 15 kilograms, ethanol with 80% 1500 kilograms of soak times are 40 hours, residue soaks 40 hours with the ethanol 1500 kilograms of 80% again, then the solution of the solution after immersion is merged, after 200 object strainer filterings, concentrate 30 times, then go up macroporous resin, with 70% ethanol eluting, collect eluent.
Embodiment 3, formula:
Liquid embodiment 2 obtained adopts concentrating under reduced pressure, is concentrated into 1/1 to five/2nd of original weight amount.
The formula of skin whitener is as follows:
Skin whitener
Production technology: first HANSHENGJIAO is dispersed in water, and increases the temperature to 80 degree simultaneously, then add other components of B phase, stir; A phase is dissolved completely in 80 degree, stirs; Be added to by A in B phase and stir homogenizing (about 4 minutes), add C phase rapid stirring after homogenizing 1,2 minutes, froth breaking is cooled to 65 degree; Then add D phase, add E phase to 40 degree after stirring, stir discharging.PH value controls at 4.0-5.0.
Remarks: in formula, plant extract formula is abbreviated as the excellent dormancy elite of E-dream5 skin.
There is control to stay up late the formula and prescription check melanin of the black eye that cause and edema effect near the eyes and the microcirculatory test report of promotion
Illustrate: 1. in following test, prescription used is and of the present inventionly has control and to stay up late the plant prescription of the black eye that cause and edema effect near the eyes;
2. Tyrosinase inhibition assays is for observing the inhibitory action of medicine to B16 cell in cell;
3. the test of melanocyte In vitro culture is for observing the inhibitory action of medicine to melanocyte vigor;
4. nail fold microcirculation measures for observing the improvement result of medicine to local skin edema.
One, Tyrosinase inhibition assays:
Method:
Reagent:
Reagent one: PBS (phosphate standard buffer solution), pH value 6.86
Reagent two: L-Dopa solution (with PBS preparation, concentration 0.15%)
Reagent three: tyrosinase solution (with PBS preparation, concentration 200 μ/ml)
Reagent four: sample solution (with PBS preparation, the several sample of configuration variable concentrations)
Application of sample:
475nm surveys absorbance
The computational methods of tyrosinase inhibition rate:
Tyrosinase inhibition rate %=[(A-B)-(C-D)]/(A-B) × 100
Result:
Two, melanocyte In vitro culture test:
Method: trophophase B16 cell routine of taking the logarithm digests, adjustment number of cells is 5 × 104/ml, and be seeded in 96 orifice plates, every hole 90 μ L, after hatching 24 hours, filters out medicine in CO2 incubator, sets up the blank group of culture medium and cell; Culture plate is placed in after incubator hatches 72 hours, abandon supernatant, PBS washes two times, then adds 1001%Triton-100, shakes after 5 minutes, after-20 DEG C of placement 1h, room temperature is melted makes the complete cracking of cell, and then every hole adds 100 μ L 0.1% levodopa solution (PBS joins), hatches 1 hour in incubator, to cultivate datum hole zeroing, under microplate reader, survey the absorbance of 460nm.
Result:
Three, nail fold microcirculation measures: microcirculation inspection: adopt MCA S-2010 type microcirculation instrument, the finger nail fold microcirculation of observation experimenter, the indexs such as all states of observing tube loop form, blood fluidised form and loop, and go out integrated value with the weighted and integral method of field Niu Shi by computer statistics.Integration is lower, shows that microcirculation improves more obvious.
Result:
Plant prescription is to experimental group (medication group) and matched group (not medication group) microcirculation integral contrast
Note: compare with before treatment, 1) P<0.01; Compare with after treatment of control group, 2) P<0.05,3) P<0.01.
Above disclosedly be only a kind of preferred embodiment of the present invention, certainly can not limit the interest field of the present invention with this, therefore according to the equivalent variations that the claims in the present invention are done, still belong to the scope that the present invention is contained.
Claims (6)
1. there is control to stay up late the plant prescription of the black eye that cause and edema effect near the eyes, it is characterized in that: comprise following composition by weight percentage: Pelargonium gravelens 1 ~ 20%, Radix Oenotherae erythrosepalae 10 ~ 30%, leucojum aestivum bulb 10 ~ 40%, Narcissus Tazetta L. Var 10 ~ 40%, flower of Sambucus nigra L. 1 ~ 20%.
2. the control that has as described in claim 1 is stayed up late the preparation method of plant prescription of the black eye that cause and edema effect near the eyes, it is characterized in that, comprises the steps:
(1) by above-mentioned plant prescription with 20% ~ 80% alcohol-pickled, the ethanol consumption (weight) soaked is prescription plant weight 20 ~ 300 times, and soak time is 2 ~ 48 hours;
(2) solution after above-mentioned immersion is concentrated 10 ~ 50 times after filtering, then by macroporous resin on concentrated solution, with the ethanol eluting of 10% ~ 98%, collect eluent.
3. the control that has as described in claim 2 is stayed up late the preparation method of plant prescription of the black eye that cause and edema effect near the eyes, it is characterized in that: the 200 object strainer filterings of the filtration in described step 2.
4. one kind has the stay up late whitening of plant prescription of the black eye that cause and edema effect near the eyes, skin nursing and eye of control maintain application in product containing according to claim 1.
5. the control that has as described in claim 1 is stayed up late the skin whitener of plant prescription of the black eye that cause and edema effect near the eyes, it is characterized in that, comprise following composition by weight percentage: A phase component: 4 methyl benzylidene camphor 1 ~ 5%, OctMet 2 ~ 7%, butyl methoxydibenzoylmethise 1 ~ 3%, 16, 18 alcohol 2 ~ 4%, dimension E acetate 1 ~ 3%, fragrant quick easypro 0.1 ~ 1%, cetearyl ether-20 1 ~ 2%, C12-15 benzoate 2 ~ 6%, renovation agent 1 ~ 4%, 1, 2, 6-ditertbutylparacresol 0.05 ~ 0.1%, propyl p-hydroxybenzoate 0.1 ~ 0.2%, B phase component: HANSHENGJIAO 0.2 ~ 0.3%, disodiumedetate 0.1 ~ 0.2%, methyl parahydroxybenzoate 0.2 ~ 0.3%, potassium cetyl phosphate 1 ~ 2%, sodium sulfite 0.05 ~ 0.2%, remaining ingredient are deionized water, C phase component: sunscreen 1 ~ 4%, D phase component: polyacrylamide 1 ~ 3%, E phase component: essence 0.01 ~ 0.3%, plant extract formula 5-10%, antiseptic 0.1 ~ 0.5%, citric acid 0.1 ~ 2%.
6. the control that has as described in claim 5 is stayed up late the preparation method of skin whitener of plant prescription of the black eye that cause and edema effect near the eyes, it is characterized in that, comprises the steps:
(1) first HANSHENGJIAO is dispersed in water, and increases the temperature to 80 degree simultaneously, then add other components of B phase, stir;
(2) A phase is dissolved completely in 80 degree, stir;
(3) be added to by A in B phase and stir homogenizing (about 4 minutes), add C phase rapid stirring after homogenizing 1,2 minutes, froth breaking is cooled to 65 degree;
(4) then add D phase, add E phase to 40 degree after stirring, stir discharging, and pH value controls at 4.0-5.0.
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| CN201410453871.9A CN104586676B (en) | 2014-09-05 | 2014-09-05 | There is control to stay up late the vegetative pole prescription of the black eye that cause and edema effect near the eyes, preparation method and application thereof |
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| CN201410453871.9A CN104586676B (en) | 2014-09-05 | 2014-09-05 | There is control to stay up late the vegetative pole prescription of the black eye that cause and edema effect near the eyes, preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021057391A1 (en) * | 2019-09-26 | 2021-04-01 | 湖南御家化妆品制造有限公司 | Composition and application thereof in preparation of skincare products for night owls |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107582505A (en) * | 2017-10-02 | 2018-01-16 | 海南京润珍珠生物技术股份有限公司 | Pearl amino acid is stayed up late shining bright facial mask and preparation method thereof |
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|---|---|---|---|---|
| WO2021057391A1 (en) * | 2019-09-26 | 2021-04-01 | 湖南御家化妆品制造有限公司 | Composition and application thereof in preparation of skincare products for night owls |
| JP2022550759A (en) * | 2019-09-26 | 2022-12-05 | 水羊化妝品製造有限公司 | Compositions and their use in the preparation of products for the care of the skin of night owls |
| JP7448642B2 (en) | 2019-09-26 | 2024-03-12 | 水羊化妝品製造有限公司 | Compositions and their use in the preparation of products for the care of the skin of night owls |
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| CN104586676B (en) | 2016-03-09 |
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