CN104575654A - Isotope label synthesizer capable of synchronously synthesizing plurality of radioactive tracers - Google Patents
Isotope label synthesizer capable of synchronously synthesizing plurality of radioactive tracers Download PDFInfo
- Publication number
- CN104575654A CN104575654A CN201410783358.6A CN201410783358A CN104575654A CN 104575654 A CN104575654 A CN 104575654A CN 201410783358 A CN201410783358 A CN 201410783358A CN 104575654 A CN104575654 A CN 104575654A
- Authority
- CN
- China
- Prior art keywords
- reaction bulb
- reaction bottle
- isotope label
- valve
- pipeline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000700 radioactive tracer Substances 0.000 title claims abstract description 22
- 230000002194 synthesizing effect Effects 0.000 title abstract description 4
- 238000006243 chemical reaction Methods 0.000 claims abstract description 30
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 10
- 238000001948 isotopic labelling Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention provides an isotope label synthesizer capable of synchronously synthesizing a plurality of radioactive tracers. The isotope label synthesizer comprises a nitrogen (1), pipelines (2), three-way valves (3), raw material bottles (4), a reaction bottle A (5), a reaction bottle B (6) and a reaction bottle C (7), and is characterized in that the nitrogen (1) is conveyed into the raw material bottles (4) through the pipelines (2); the raw material bottles (4) are connected with the three-way valves (3) through the pipelines (2); the three-way valves (3) are connected with the reaction bottle A (5), the reaction bottle B (6) and the reaction bottle C (7) through the pipelines (2). The isotope label synthesizer can synchronously synthesize three tracers, and has the advantages of saving time, economizing raw materials, and reducing cost..
Description
Technical field
The present invention relates to labelled with radioisotope synthesis field, especially design a kind of isotope labeling synthesizer that simultaneously can synthesize multiple radiotracer.
Background technology
Molecular imaging development in recent years is rapid, and PET-CT (Positron Emission Computed Tomography) uses positron emitting tracer, can early detection disease in the diagnosis of tumour, heart and nervous system various disease.The radioactive nuclides such as 18F, 11C, 13N are manufactured by cyclotron, then by chemistry synthesis module (also claiming compositor) by these radioisotope labelings on different chemical substrate, synthesize the final various radiopharmaceutical for Clinical practice.Because positron emitting tracer has the characteristic that radioactivity is high, the half life period is short, therefore all use trace reagent by chemistry synthesis module fully automated synthesis, due to positron medicine, its preparation process automaticity is very high.For PET-CT video picture, although have developed many new positron emitting tracers at present, 18F-FDG has remained the developer that Clinical practice is maximum, range of application is maximum.
Various synthesizers external at present are all merely able to synthesize a kind of radiotracer, even this synthesizer of FDG4 of the Explorer-FDG4 of Siemens and Beijing group spy also can only synthesize repeatedly FDG4, can not produce multiple radioactive label product simultaneously.
And in actual applications, in the performance history of especially Novel radioactive tracer agent, do not need a certain radiotracer that single sintering is a large amount of, but the tracer agent of multiple low dose, existing equipment just can not meet this condition, after can only synthesizing once, carries out equipment and clears out a gathering place, carry out the production that next plants tracer agent after waiting for 10 half life period of radioactivity decay, generally this process need was more than 24 hours.This just brings following problem:
1. time waste.Need can once test for 24 hours;
2. empirical model is different gives tracer agent relatively simultaneously, affects evaluation of result.Such as, once researchist wants to investigate different developers to the Detectable effects of a certain tumour, owing to can not synthesize various developer simultaneously, therefore the time that these developers act on this tumour generally can differ more than at least one sky, likely tumour itself changes, and is unfavorable for intuitively comparing;
3. waste starting material.In radiotracer building-up process, first can produce radioactive 18F by accelerator, even if demand little again, also must once bombard, utilization rate will be caused so low, cause the increase of cost.Disposablely synthesize multiple tracer agent simultaneously and then can effectively address this problem.
Summary of the invention
In order to solve traditional Problems existing, the invention provides following technical scheme is:
A kind of isotope labeling synthesizer that simultaneously can synthesize multiple radiotracer, comprise nitrogen, pipeline, T-valve, stock bottle, reaction bulb A, reaction bulb B, reaction bulb C, it is characterized in that, described nitrogen enters in stock bottle by Cemented filling, described stock bottle is connected with T-valve by pipeline, and described T-valve is connected with reaction bulb A, reaction bulb B, reaction bulb C by pipeline.
Further, described stock bottle has 5.
Further, described T-valve has 7.
The beneficial effect that the present invention brings is:
1. can synthesize three kinds of tracer agents simultaneously, save the time;
2. saved starting material, especially crucial 18F isotope, reduces cost;
3. can prepare multiple developer can test simultaneously simultaneously, obtain series data under similar conditions, obtain the experimental result of comparability.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Number in the figure is:
1-nitrogen 2-pipeline 3-T-valve 4-stock bottle
5-reaction bulb A 6-reaction bulb B 7-reaction bulb C
Embodiment
Below to being elaborated preferred embodiment of the present invention by reference to the accompanying drawings, can be easier to make advantages and features of the invention be readily appreciated by one skilled in the art, thus more explicit defining is made to protection scope of the present invention.
As shown in Figure 1, a kind of isotope labeling synthesizer that simultaneously can synthesize multiple radiotracer, comprise nitrogen 1, pipeline 2, T-valve 3, stock bottle 4, reaction bulb A5, reaction bulb B6, reaction bulb C7, described nitrogen 1 is conveyed in stock bottle 4 by pipeline 2, described stock bottle 4 is connected with T-valve 3 by pipeline 2, described T-valve 3 is connected with reaction bulb A5, reaction bulb B6, reaction bulb C7 by pipeline 2, and described stock bottle 4 has 5, and described T-valve 3 has 7.
When having use: according to the form of synthesizing three kinds of tracer agents simultaneously, utilize T-valve 3 as fluid control methods, the preset stock bottle 4 that likely uses and reaction bulb A5, reaction bulb B6, reaction bulb C7, adopt nitrogen 1 as expulsive force.
In sum, the present invention can synthesize three kinds of tracer agents simultaneously, has the advantage saving time, save material, reduce costs.
The above; be only one of the specific embodiment of the present invention; but protection scope of the present invention is not limited thereto; any those of ordinary skill in the art are in the technical scope disclosed by the present invention; the change can expected without creative work or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should limit with claims is as the criterion.
Claims (3)
1. one kind can be synthesized the isotope labeling synthesizer of multiple radiotracer simultaneously, comprise nitrogen (1), pipeline (2), T-valve (3), stock bottle (4), reaction bulb A (5), reaction bulb B (6), reaction bulb C (7), it is characterized in that, described nitrogen (1) is conveyed in stock bottle (4) by pipeline (2), described stock bottle (4) is connected with T-valve (3) by pipeline (2), described T-valve (3) is by pipeline (2) and reaction bulb A (5), reaction bulb B (6), reaction bulb C (7) connects.
2. a kind of isotope labeling synthesizer that simultaneously can synthesize multiple radiotracer according to claim 1, it is characterized in that, described stock bottle (4) has 5.
3. a kind of isotope labeling synthesizer that simultaneously can synthesize multiple radiotracer according to claim 1, it is characterized in that, described T-valve (3) has 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410783358.6A CN104575654A (en) | 2014-12-16 | 2014-12-16 | Isotope label synthesizer capable of synchronously synthesizing plurality of radioactive tracers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410783358.6A CN104575654A (en) | 2014-12-16 | 2014-12-16 | Isotope label synthesizer capable of synchronously synthesizing plurality of radioactive tracers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104575654A true CN104575654A (en) | 2015-04-29 |
Family
ID=53091520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410783358.6A Pending CN104575654A (en) | 2014-12-16 | 2014-12-16 | Isotope label synthesizer capable of synchronously synthesizing plurality of radioactive tracers |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104575654A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1407401A (en) * | 2001-08-16 | 2003-04-02 | 伊斯曼柯达公司 | Three portion concentrated color developer set and its use |
| CN1482922A (en) * | 2000-12-22 | 2004-03-17 | ������Ӧ�ùɷ�����˾ | Device for synthesis of radiopharmaceutical products |
| CN1911947A (en) * | 2006-09-01 | 2007-02-14 | 郭启勇 | Synthesis technology of 18F labelled positive electron radioactive tracer precusor |
| CN1966140A (en) * | 2006-03-22 | 2007-05-23 | 上海化工研究院 | Chemical synthesizer capable of preparing multiple fluoro-marking agent |
| CN101333138A (en) * | 2008-07-23 | 2008-12-31 | 北京师范大学 | Device and process capable of simultaneously preparing three different <18>F radiopharmaceuticals |
| CN204407025U (en) * | 2014-12-16 | 2015-06-17 | 江苏华益科技有限公司 | The isotope labeling synthesizer of multiple radiotracer can be synthesized simultaneously |
-
2014
- 2014-12-16 CN CN201410783358.6A patent/CN104575654A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1482922A (en) * | 2000-12-22 | 2004-03-17 | ������Ӧ�ùɷ�����˾ | Device for synthesis of radiopharmaceutical products |
| CN1407401A (en) * | 2001-08-16 | 2003-04-02 | 伊斯曼柯达公司 | Three portion concentrated color developer set and its use |
| CN1966140A (en) * | 2006-03-22 | 2007-05-23 | 上海化工研究院 | Chemical synthesizer capable of preparing multiple fluoro-marking agent |
| CN1911947A (en) * | 2006-09-01 | 2007-02-14 | 郭启勇 | Synthesis technology of 18F labelled positive electron radioactive tracer precusor |
| CN101333138A (en) * | 2008-07-23 | 2008-12-31 | 北京师范大学 | Device and process capable of simultaneously preparing three different <18>F radiopharmaceuticals |
| CN204407025U (en) * | 2014-12-16 | 2015-06-17 | 江苏华益科技有限公司 | The isotope labeling synthesizer of multiple radiotracer can be synthesized simultaneously |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150429 |
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| RJ01 | Rejection of invention patent application after publication |