CN104548381A - Soft-foundation conformal uniform light irradiation photodynamics therapy device - Google Patents

Abstract

The invention relates to a photodynamic therapy device for soft-base conformal uniform light irradiation. The treatment device obtains the size of the treated patient area through three-dimensional reconstruction of the lesion area on the body surface. The contact surface is composed of flexible silica gel and other highly transparent soft matrix materials. Introduced by optical fiber, the treatment light is evenly distributed through the dodging plate and transparent liquid. This kind of photodynamic therapy device can be precisely fitted to the lesion area, and at the same time, the number of optical fibers, therapeutic light power and therapeutic light wavelength can be changed according to the needs of treatment, so as to meet different requirements for body surface photodynamic therapy and improve the treatment effect.

Description

A photodynamic therapy device for conformal and uniform light irradiation on soft ground

technical field

The invention relates to a photodynamic therapy device for soft-base, conformal and uniform light irradiation, which is suitable for photodynamic therapy of contact irradiation of body surface skin diseases, such as port wine stains, acne and the like.

technical background

Photodynamic therapy (PDT) is the use of photosensitizers and specific wavelengths of light to generate photodynamic reactions, that is, a series of photochemical reactions. The reaction products (excited singlet oxygen molecules) have strong oxidative properties and can kill the surrounding Diseased cells are a new technology to achieve the purpose of treatment. Compared with traditional treatment schemes, PDT has the advantages of small side effects, low toxicity, good selection applicability, and minimal invasiveness.

There are three key influencing factors in photodynamic therapy: photosensitizer, light source and oxygen molecules in cells. At present, the light sources of various photodynamic therapy instruments are mostly fixed on the hard substrate, which cannot be adjusted according to the treatment requirements. As a result, different parts or different curvatures and different angles of the same part receive different optical power densities, such as the face and neck. The treatment light source cannot vertically and uniformly irradiate the skin of the lesion area with different curvature directions and different angles at the same time, and the skin in the lesion area receives a large difference in optical power density, which greatly affects the treatment effect. In addition, during the process of photodynamic therapy, due to the high energy of the therapeutic light band, it will heat the treatment site and make the patient feel a little uncomfortable. This device uses highly transparent liquid as the light transmission medium, which can not only improve the uniformity of the treatment light, but also Reduce the temperature of the lesion area and reduce the pain of patients during treatment.

Contents of the invention

The invention is a photodynamic therapy device for body surface skin diseases, through the combination of the devices, uniform irradiation of therapeutic light in various positions and directions of the lesion area can be realized.

The technical solution of the present invention is: use the three-dimensional reconstruction system to carry out three-dimensional reconstruction of the lesion area to determine the area and shape of the lesion area, obtain a plane of the corresponding size after three-dimensional unfolding, and combine highly transparent and flexible materials with a uniform light plate and reflective film on the inner surface The hard plate forms two closed cavities at the front and back, and the front cavity is filled with highly transparent liquid. The treatment light source is introduced through the optical fiber, and the end of the optical fiber is inserted into the treatment device. The chamber cover can be made into plates with different numbers of holes, so as to insert different numbers of optical fibers and introduce therapeutic light with different optical power densities for treatment.

Description of drawings

Fig. 1 is the treatment chart of this photodynamic therapy device

Figure 2 is a three-dimensional structure diagram of the device

The left side of Fig. 3 is the front view of the device, and the right side is the cross-sectional view of the front view along A----A.

In Figure 2, 1 is an optical fiber, 2-1 is a uniform plate, 2-2 is a highly transparent liquid, and 2-3 is a highly transparent flexible material

specific implementation plan

As shown in Figure 1, firstly, according to the 3D reconstruction model of the patient's lesion area by the 3D reconstruction system, the planar structural model of the lesion area is obtained, and a suitable (2-3) highly transparent and flexible material is selected, combined with (2-1) dodging plate and inner The baffle plate coated with reflective film on the surface is made into a closed cavity with the same contact surface as the lesion area. The front cavity is filled with (2-2) highly transparent liquid. In order to improve the treatment effect, it is required that the front cavity cannot be filled with liquid. If there are air bubbles, select the corresponding number of (1) optical fibers to guide the therapeutic light source of the corresponding wavelength according to the treatment needs, and insert them on the back cover at a suitable position from the end of the (1) optical fiber to the (2-1) uniform light plate. (2-3) The highly transparent flexible material just covers the lesion area on the body surface, so that the treatment light can be projected vertically and evenly on the lesion area, and the light density in the treatment area is evenly distributed. At the same time, (2-2) highly transparent liquid is used, It can not only make the distribution of optical power density uniform, but also cool down the temperature of the lesion area, making the treatment process more comfortable.

The foregoing descriptions are merely examples of the present invention, and do not impose any formal restrictions on the structure of the present invention. All simple modifications, equivalent changes and modifications made to the above embodiments according to the technical essence of the present invention still fall within the scope of the technical solutions of the present invention.

Claims (4)

1. A photodynamic therapy device with conformal and uniform light irradiation on a soft base, which is characterized in that it can be adjusted according to the size and severity of the lesion area on the body surface, the contact surface can completely fit the lesion area, and the treatment light can evenly irradiate the lesion area . 2. A soft-base conformal and uniform light-irradiated photodynamic therapy device according to claim 1, characterized in that the contact surface with the body surface is composed of highly transparent soft matrix materials such as flexible silica gel. 3. A photodynamic therapy device for conformal and uniform light irradiation on soft ground according to claim 1, characterized in that the treatment light source is introduced from the rear of the device through optical fibers, and the number of optical fibers and the wavelength of the light source can be determined by the severity of the disease. 4. A photodynamic therapy device for conformal uniform light irradiation on a soft base according to claim 1, characterized in that the treatment light source can only reach the treatment area after passing through a uniform light system composed of a uniform light plate and a highly transparent liquid.