CN104547585A - External traditional Chinese medicine composition and preparation for treating swelling and pain, cut wounds and skin ulcers - Google Patents

Abstract

The invention relates to an external Chinese medicine composition for treating swelling, pain, incision wound and skin ulcer. The Chinese medicine composition is processed from the raw materials of perilla, peppermint, asarum, rhubarb, nitrate, nepeta, bletilla striata, windproof, atractylodes and licorice The external preparation made from the traditional Chinese medicine composition and auxiliary agent includes powder, tincture, spray, patch, paste and ointment; the present invention also relates to the preparation method of the above traditional Chinese medicine composition and preparation. The traditional Chinese medicine composition of the invention is used for treating unknown swelling and pain, incision wound and skin ulcer, and has the advantages of quick effect, high cure rate, obvious analgesic effect, strong effect of dispelling blood stasis and reducing swelling, and short wound healing time.

Description

Externally applied traditional Chinese medicine composition and preparation for treating swelling and pain, incision wound and skin ulcer

technical field

The invention belongs to the field of pharmaceutical preparations, in particular to an external Chinese medicinal composition for treating swelling and pain, incision wounds and skin ulcers and preparations thereof.

Background technique

Trauma refers to external damage to the body or objects caused by blows, collisions, or erosion of chemical substances; specifically, it includes bullets, metal blades, bruises, serious injuries, burns, frostbite, and insect injuries. For all kinds of trauma, regardless of the size and depth of the wound, timely and correct treatment must be carried out. If the treatment is not done properly, the wound will cause bleeding, infection, suppuration, and in severe cases, tetanus, limb amputation, and even life-threatening. Correct wound treatment can make it heal quickly; on the contrary, it may be suppurative and infected, which will not heal for a long time, and even be life-threatening due to concurrent systemic infection, gas gangrene, and tetanus.

Existing topical medicines for treating trauma include alcohol, tincture of iodine, complex iodine, hydrogen peroxide, and chlorophyll, etc. for sterilization, and western medicine preparations for anti-inflammatory and muscle-promoting include sulfonamide powder, sulfonamide ointment, etc., which are used for dispersing silt Chinese medicine oils that stop bleeding and promote muscle growth include Wanhua oil, safflower oil, etc., and Chinese medicine powders include Yunnan Baiyao. These medicines have been proved through long-term clinical practice that they all have different degrees of curative effect, some of which vary from person to person, and some of which vary from injury to condition. Another example is that the application document with the patent application number CN201010191973.X discloses a kind of externally used medicine for treating trauma and its preparation method. Liquid as the main raw material, adding auxiliary raw materials to form an external emulsion drug with functions such as dispersing silt, reducing swelling, stopping bleeding, relieving pain, reducing inflammation, and promoting muscle growth. Patent application number CN201110032186.5 discloses a traditional Chinese medicine composition for treating knife wounds, burns and various wounds. Drainage, Panax notoginseng, Angelica dahurica, Eucommia ulmoides, peach kernel, angelica, cinnamon stick, frankincense, and akebia, which are made into medicinal powder and medicinal wine respectively, which can be used to treat various wounds such as knife wounds, burns, and scalds.

However, most of the above-mentioned medicines have problems such as poor curative effect, slow effect, insufficient analgesic effect, weak effect of dissipating blood stasis and detumescence, and long wound healing time; and the raw materials used in the external medicines prepared by traditional Chinese medicine have single drug effects, and the types of raw materials are relatively large. Many, some traditional Chinese medicine raw materials have no synergistic effect with other raw materials, which affects the overall curative effect of the traditional Chinese medicine composition. In addition, most of the existing traditional Chinese medicine compositions use the raw materials directly crushed into medicine, without extracting and separating the active ingredients in the raw materials, the non-effective ingredients are not removed, and there are many impurities, which makes the prescription of the traditional Chinese medicine composition too large, which is not conducive to Patient takes, further influences the curative effect of Chinese medicine composition.

Contents of the invention

In order to solve the above-mentioned technical problems, the present invention provides an external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers and its preparation with quick onset, short course of treatment and high cure rate.

Concrete technical scheme of the present invention is as follows:

The invention provides an external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers. The external Chinese medicine composition is mainly prepared by processing the following raw materials in parts by weight:

The external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers provided by the present invention has significant curative effects such as dispelling stasis, detumescence, pain relief, hemostasis, anti-inflammation, and muscle growth. As high as 97.7%, and the patient's wounded surface grows muscle quickly.

Preferably, the traditional Chinese medicine composition for external use is mainly processed and prepared from the following raw materials in parts by weight:

Further rationally optimize the formula of the present invention, the traditional Chinese medicine composition for external use is mainly prepared by processing the raw materials of the following parts by weight:

For the convenience of taking and carrying, the present invention provides preparations made of external Chinese medicine compositions and adjuvants for treating swelling, pain, incision wounds and skin ulcers, said preparations include powders, tinctures, sprays, plasters, pastes and ointments agent, the weight ratio of the composition and the auxiliary material is 1:0.1-12.

As a further improvement, the present invention makes a paste from the traditional Chinese medicine composition for external use and auxiliary materials, and the auxiliary materials are composed of the following components in parts by weight: 120 parts of white wine of 50-60 degrees or 120 parts of medical alcohol of 60-70 degrees, sodium benzoate 3 share. After injecting white wine or medical alcohol into the above-mentioned traditional Chinese medicine raw materials, place them at room temperature for 3 days, then sterilize and bottle them; wherein the use of sodium benzoate can increase the storage period of the pharmaceutical preparations.

As a further improvement, the present invention makes an ointment from the traditional Chinese medicine composition for external use and auxiliary materials, and the auxiliary materials are composed of the following components in weight fractions: 20 parts of stearic acid, 26 parts of beeswax, 15 parts of stearyl alcohol, 20 parts of glycerin, 1.5 parts of sucrose fatty acid ester, 2 parts of polyoxyethylene castor oil, 1 part of benzalkonium bromide, 2.4 parts of limonene and 80 parts of purified water.

The ointment prepared by this formula is an emulsion type ointment, in which stearic acid, beeswax and stearyl alcohol are selected as bases to improve the drug release and bioavailability of the active ingredients of the drug; the use of limonene further promotes the transdermal absorption of the drug; sucrose fat Ester plays the role of emulsification and adhesion, and sucrose fatty acid ester and polyoxyethylene castor oil form a uniform dispersion with the traditional Chinese medicine composition. The mixture of sucrose fatty acid ester and sorbitol in this ratio can significantly improve the stability of the ointment ; Benzalkonium bromide is used as a preservative. The above-mentioned substances and the traditional Chinese medicine composition are made into a paste, which can improve the content uniformity of the ointment, give full play to the therapeutic effect of the traditional Chinese medicine composition on various traumas, and significantly improve the curative effect.

Another aspect of the present invention also provides a preparation method of an external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers: the raw materials in parts by weight are respectively pulverized into coarse powder, and the coarse powder is dried in an oven at 60°C After 240 minutes, the coarse powder is crushed after mixing, passed through an 80-mesh sieve, and ground into a fine powder, which is a traditional Chinese medicine composition for external use.

For extracting the active ingredient of the traditional Chinese medicine composition more finely, the present invention provides a kind of preparation method of the external Chinese medicine composition for treating swelling and pain, incision wound and skin ulceration, comprising the following steps:

a) dissolving the nitrate in said weight portion with hot water, centrifuging, cooling to precipitate crystals, pulverizing through an 80-mesh sieve to obtain crystal powder;

b) Take the Herba Asarum, Rhubarb, Schizonepeta and Atractylodes Rhizoma Atractylodis in said weight parts and add ethanol to reflux for three times, add 10 times the amount of 90% ethanol for the first time, and reflux for 3 hours; add 7 times the amount of 90% ethanol for the second time , reflux extraction for 2 hours; add 4 times the amount of 90% ethanol for the third time, reflux extraction for 1 hour; combine the reflux liquid, filter, and combine to obtain solution 1;

c) decoct the perilla, mint, windproof, bletilla striata and licorice for 2 times, the first time decoct 15 times the amount of water for 4 hours, the second time 10 times the amount of water for 1.5 hours, and combine the filtrates , concentrated at a temperature of 55°C to a relative density of 1.00-1.15g/ml, cooled, added 60-70% ethanol, stood for 24 hours, filtered, and the filtrate was concentrated at a temperature of 55°C to a relative density of 1.00- 1.25g/ml thick paste, add water to 60% of the total amount, let it stand for 20 hours, take the supernatant, and obtain solution 2;

d) Mix solution 1 and solution 2 evenly, and vacuum-dry at a temperature of 50°C and a pressure of -0.05MPa to obtain a fine powder;

e) mixing the crystal powder in step a) and the fine powder in step d) evenly to obtain an external Chinese medicine composition for treating swelling, pain, incision wound and skin ulcer.

The preparation method of the traditional Chinese medicine composition provided by the present invention can extract the active ingredients in each traditional Chinese medicine raw material medicine, reduce the dosage of ingredients that do not play a role, further improve the curative effect of the traditional Chinese medicine composition, and realize cost saving while maintaining It has the advantages of high yield, good product quality, simple process and the like, and is suitable for industrialized production.

On the other hand, the present invention also provides the preparation method of ointment, and this method comprises the steps:

a) preparing a traditional Chinese medicine composition for external use, for subsequent use;

b) Take the stearic acid, beeswax and stearyl alcohol in the stated parts by weight, heat in a water bath at a temperature of 70-90° C., stir until fully melted, and form an oil phase;

c) Take the composition of step a), glycerin, sucrose fatty acid ester, polyoxyethylene castor oil, benzalkonium bromide, and limonene in a water bath, dissolve in purified water, and heat to 70-90°C to form an aqueous phase;

d) Slowly pour the oil phase in step b) into the oil phase in step c), and stir while adding, until it cools to 45°C, continue stirring, and fill to obtain an ointment.

Further, the application of the traditional Chinese medicine composition for external use in the preparation of medicines for treating lymph node inflammation, bee stings, bruises, incision wounds and skin ulcers.

The source of crude drug of the present invention is as follows:

Perilla: The young leaves with branches of Perilla frutescens (L.) Britt.

Mint: This product is the dry aerial part of Mentha haplocalyx Briq.

Asarum: This product is the dry whole of Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag., Asarum sieboldii Miq. var. seoulense Nakai or Asarum sieboldii Miq. Grass.

Rhubarb: This product is the dry root and rhizome of Rheum palmatum L., Rheum tanguticum Maxim.ex Balf. or medicinal Rheum officinale Baill. of Polygonaceae.

Glauber's salt: also known as Glauber's salt, is a common name for sodium sulfate containing crystal water; Glauber's salt is a crystal that is processed and refined from a widely distributed sulfate mineral.

Nepeta: This product is the dry aerial part of Schizonepeta tenuifolia Briq.

Bletilla striata: This product is the dry tuber of the orchid plant Bletilla striata (Thunburcz) Reichb.f.

Windproof: This product is the root of Saposhnikovia divaricate (Turcz.) Schischk. plant of Umbelliferae.

Atractylodes: This product is the dry rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. of Compositae.

Licorice: This product is the dry root of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the leguminous plant Glycyrrhiza uralensis Fisch.

The traditional Chinese medicine composition provided by the present invention is a kind of pure traditional Chinese medicine medicine for treating trauma developed by the applicant. The powder of the traditional Chinese medicine composition "Texiaosan" has been mass-produced and widely used in clinical treatment.

The traditional Chinese medicine composition of the present invention is mainly used for diseases such as nameless swollen toxins (for example: lymph node inflammation, bee stings, bruises, etc.), incision wounds, and skin ulcers; it is characterized by quick results, high cure rate, and obvious analgesic effect , Dispersing blood stasis and detumescence is strong and wound healing time is short.

Detailed ways

Embodiment 1 external use Chinese medicine composition

An external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers. The external Chinese medicine composition is prepared by processing the following raw materials in parts by weight:

Perilla 15g Mint 10g Asarum 8g Rhubarb 15g

Pu Nitrate 16g Nepeta 12g Baiji 15g Fangfeng 12g

Cangzhu 9g, licorice 9g.

Preparation:

a) dissolving the nitrate in said weight portion with hot water, centrifuging, cooling to precipitate crystals, pulverizing through an 80-mesh sieve to obtain crystal powder;

b) Take the Herba Asarum, Rhubarb, Schizonepeta and Atractylodes Rhizoma Atractylodis in said weight parts and add ethanol to reflux for three times, add 10 times the amount of 90% ethanol for the first time, and reflux for 3 hours; add 7 times the amount of 90% ethanol for the second time , reflux extraction for 2 hours; add 4 times the amount of 90% ethanol for the third time, reflux extraction for 1 hour; combine the reflux liquid, filter, and combine to obtain solution 1;

c) decoct the perilla, mint, windproof, bletilla striata and licorice for 2 times, the first time decoct 15 times the amount of water for 4 hours, the second time 10 times the amount of water for 1.5 hours, and combine the filtrates , concentrated at a temperature of 55°C to a relative density of 1.00-1.15g/ml, cooled, added 60-70% ethanol, stood for 24 hours, filtered, and the filtrate was concentrated at a temperature of 55°C to a relative density of 1.00- 1.25g/ml thick paste, add water to 60% of the total amount, let it stand for 20 hours, take the supernatant, and obtain solution 2;

d) Mix solution 1 and solution 2 evenly, and vacuum-dry at a temperature of 50°C and a pressure of -0.05MPa to obtain a fine powder;

e) mixing the crystal powder in step a) and the fine powder in step d) evenly to obtain an external Chinese medicine composition for treating swelling, pain, incision wound and skin ulcer.

Embodiment 2 external use Chinese medicine composition

An external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers. The external Chinese medicine composition is prepared by processing the following raw materials in parts by weight:

Basil 25g Mint 16g Asarum 2g Rhubarb 5g

Pu Nitrate 28g Nepeta 20g Bletilla striata 6g Fangfeng 5g

Cangzhu 16g, licorice 3g.

Preparation method: respectively pulverize the crude drug in said parts by weight into coarse powder, dry the coarse powder in an oven at 60°C for 240 minutes, pulverize the coarse powder after mixing, pass through an 80-mesh sieve, and grind into a fine powder for external use Chinese medicine composition.

Embodiment 3 external use Chinese medicine composition

An external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers. The external Chinese medicine composition is prepared by processing the following raw materials in parts by weight:

Preparation method: prepared according to the method described in Example 1.

Embodiment 4 external use Chinese medicine composition

An external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers. The external Chinese medicine composition is prepared by processing the following raw materials in parts by weight:

Preparation method: prepared according to the method described in Example 2.

Embodiment 5 external use Chinese medicine composition

An external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers. The external Chinese medicine composition is prepared by processing the following raw materials in parts by weight:

Preparation method: prepared according to the method described in Example 1.

Embodiment 6 external use Chinese medicine composition

An external Chinese medicine composition for treating swelling and pain, incision wounds and skin ulcers. The external Chinese medicine composition is prepared by processing the following raw materials in parts by weight:

Preparation method: prepared according to the method described in Example 1.

Example 7 Paste

Chinese medicine composition prepared by embodiment 1 100g

Accessories: 50-60% liquor 105g

Sodium Benzoate 2.5g

Preparation:

a) weighing the prepared external Chinese medicine composition, white wine and sodium benzoate according to the weight component ratio, and set aside;

b) adding said white wine in the composition by weight, stirring evenly, and standing at room temperature for 3 days, sterilizing and bottling to obtain the paste for external use.

Example 8 Paste

Chinese medicine composition prepared by embodiment 1 100g

Accessories: 50-60% liquor 105g

Sodium Benzoate 2.5g

Preparation:

a) weighing the prepared external Chinese medicine composition, white wine and sodium benzoate according to the weight component ratio, and set aside;

b) adding the white wine in said weight portion to the composition, and stirring evenly to obtain solution 1;

c) Add the sodium benzoate in said weight portion to the composition solution 1, stir evenly, and place at room temperature for 3 days, sterilize, bottle, and obtain the paste for external use.

Example 9 Paste

Chinese medicine composition prepared by embodiment 1 100g

Excipients: 60-70% medical alcohol 120g

Sodium Benzoate 3g

Preparation:

a) weighing the prepared traditional Chinese medicine composition for external use, medical alcohol and sodium benzoate according to the weight component ratio, and set aside;

b) adding the medical alcohol in the weight part to the composition, and stirring evenly to obtain solution 1;

c) Add the sodium benzoate in said weight portion to solution 1, stir evenly, and place at room temperature for 3 days, sterilize, bottle, and obtain the paste for external use.

Embodiment 10 ointment

Preparation:

a) preparing a traditional Chinese medicine composition for external use, for subsequent use;

b) Take the stearic acid, beeswax and stearyl alcohol in the stated parts by weight, heat in a water bath at a temperature of 70-90° C., stir until fully melted, and form an oil phase;

c) Take the composition of step a), glycerin, sucrose fatty acid ester, polyoxyethylene castor oil, benzalkonium bromide, and limonene in a water bath, dissolve in purified water, and heat to 70-90°C to form an aqueous phase;

d) Slowly pour the oil phase in step b) into the oil phase in step c), and stir while adding, until it cools to 45°C, continue stirring, and fill to obtain an ointment.

Embodiment 11 ointment

Preparation:

a) preparing a traditional Chinese medicine composition for external use, for subsequent use;

b) Take the stearic acid, beeswax and stearyl alcohol in the stated parts by weight, heat in a water bath at a temperature of 70-90° C., stir until fully melted, and form an oil phase;

c) Take the composition of step a), glycerin, benzalkonium bromide, and limonene in a water bath, dissolve in purified water, and heat to 70-90°C to form an aqueous phase;

d) Slowly pour the oil phase in step b) into the oil phase in step c), and stir while adding, until it cools to 45°C, continue stirring, and fill to obtain an ointment.

Embodiment 12 patch

Preparation:

a) preparing a traditional Chinese medicine composition for external use, for subsequent use;

b) After adding an appropriate amount of soluble starch, glycerin and paraben and an appropriate amount of purified water to make a paste, use a coating machine to evenly coat the paste drug on the non-woven fabric, heat and dry, and cover the release paper or a release film, and then pressed into tablets; finally cut, inspected and packaged to obtain a patch.

Example 13 Spray

The composition prepared in embodiment 5 100g

Preparation method: put the crushed and sieved composition into a spray bottle, 20ml per bottle, which is the spray.

Test Example 1 Stability Test

accelerated test

Get the ointment of embodiment 10 of the present invention and embodiment 11, divide into 3 batches respectively at random, number respectively as sample 1, sample 2, sample 3, sample 4, sample 5 and sample 6, above 6 batches of samples are all heated at 40 ℃ Store at ±2°C and relative humidity of 75%±5% for 6 months, take samples at the end of the test period at 1 month, 2 months, 3 months, and 6 months respectively, according to the regulations in the Chinese Pharmacopoeia, The properties, content (marked amount %), dissolution rate and related substances (%) of acteoside were detected.

As can be seen from the results, the ointment provided by the embodiment of the present invention 10 can be known through accelerated test results, after placing for 6 months, the properties of the ointment, the amount containing acteoside, dissolution rate and related substances did not occur. Obvious change; and after the ointment of embodiment 11 was placed 6 months, the color of the ointment deepened, and the content of acteoside declined, and the stripping was uneven, and the amount of related substances increased significantly; it was shown that the ointment of embodiment 10 and embodiment Compared with 11, the stability is higher, that is, the addition of sucrose fatty acid ester and polyoxyethylene castor oil improves the formability and stability of the ointment.

5.3 Long-term test

In addition, the 6 batches of samples in 5.2 were placed at a temperature of 25°C±2°C and a relative humidity of 60%±10% for 12 months, and samples were taken every 3 months, at 0 months and 1 month respectively. , 3 months, 6 months, 9 months, and 12 months, samples were taken to detect the properties of the ointment, the content of acteoside (marked amount %), dissolution rate and related substances (%).

From the results, it can be seen that the ointment provided by Example 10 of the present invention, through long-term test results, after being placed for 12 months, the properties of the ointment, the amount containing acteoside, dissolution rate and related substances did not occur. Obvious change; And the ointment color and luster of embodiment 11 is deepened, and the content of acteoside significantly descends, and dissolution is uneven, and the amount of related substance significantly increases; Show that sucrose fatty acid ester, polyoxyethylene castor oil composition have improved the ointment formability and stability.

Test Example 2 Clinical Trial

2.1 Diagnostic criteria

According to the records in "Diagnostics of Chinese and Western Medicine", nameless swelling and pain, incision wound and skin ulceration.

2.2 Test case

A total of 152 patients were admitted, all aged between 15 and 50 years old; all of them were confirmed by examination, 62 patients with unknown swelling and pain, 46 patients with incision wounds and 44 patients with skin ulcers; among them, patients with unknown swelling and pain specifically included lymph node inflammation, Symptoms of bee stings and bruises.

2.3 Grouping and administration

62 patients with nameless swelling and pain were randomly divided into a treatment group of 38 cases and a control group of 24 cases; 46 patients with incision wounds were randomly divided into a treatment group of 26 cases and a control group of 20 cases; 44 patients with skin ulcers were randomly divided into a treatment group of 24 cases. 20 cases in the control group.

The above unknown swelling and pain treatment group is given the traditional Chinese medicine composition made in Example 1 of the present invention. The usage is to directly sprinkle the powder of the composition on the wound. The recorded course of treatment is 15 days, and the usage is 2 times/day; incision wound and skin ulceration treatment All groups were given the paste made by Example 7 of the present invention, and the recorded course of treatment was 15 days, and the usage was 2 times/day; the control group was given safflower oil smear, twice a day, and the recorded course of treatment was 15 days.

2.4 Observation method

For each patient, the medical history, signs, diagnosis, location and nature of pain and related physical and physiological examinations were all recorded.

2.5 Evaluating Criteria for Efficacy

Cured: After treatment, all the symptoms disappeared and reached the clinical cure standard;

Significantly effective: After treatment, the symptoms and signs of the condition are obviously improved;

Effective: After treatment, the symptoms and signs of the disease have improved;

Ineffective: no change before and after treatment.

2.6 Treatment Analysis

After collation and analysis of the clinical data of the patients, the treatment group and the control group were compared in the four criteria of recovery, markedly effective, effective and ineffective, and the difference between the treatment group and the control group was verified by t test.

2.7 Results

Patients in the treatment group and the control group were administered for 15 days; the comparison of the therapeutic effects of the two groups of medicines on inexplicable swelling and pain, incision wounds and skin ulcers is shown in Table 1-3, respectively.

Table 1 Comparison of therapeutic effect on innominate swelling and pain between treatment group and control group

There was a significant difference between the treatment group and the control group (P ^a <0.01);

Table 2 Comparison of therapeutic effect on incision wound between treatment group and control group

There was a significant difference between the treatment group and the control group (P ^a <0.05);

Table 2 Comparison of therapeutic effects on skin ulcers between the treatment group and the control group

There was a difference between the treatment group and the control group (P ^a <0.05);

2.8 Clinical observation verification

The composition for treating swelling and pain, incision wound and skin ulcer and paste thereof provided by the present invention have significant curative effect on lymph node inflammation, bee sting, bruises, incision wound and skin ulcer, and about 61% of patients' wounds are cured after treatment. After disappearing, no scar remains; the total effective rate of treatment reaches 97.7%. During the verification of the curative effect of the composition of the present invention, no adverse reactions and side effects are found, and the analgesic effect is obvious, the effect of dispelling blood stasis and reducing swelling is strong, and the wound healing time is short.

Typical cases

Huang, female, 23 years old, had pain in the lymph node and felt discomfort for about 10 days; after inspection, it was lymph node inflammation, and the composition of the present invention was applied to the wound in paste form, 2 times a day, and the pain was relieved after 2 hours of use. After 3 days, the swelling disappeared.

Gao, male, 35 years old, was stung by swarms of bees. The injured parts were the head, face, neck, and upper limbs. Dizziness, headache, trance, irritability and other nervous system symptoms; after local wound treatment, use the paste of the composition of the present invention, 3 times a day, scab after 3 days of use, clinical symptoms disappear, liver and kidney function is normal; stop medication, After 12 days, the wound disappeared and healed.

Song, male, 29 years old, wrestled with a motorcycle and caused abrasions on his face and arms. The wound was red, swollen and bleeding. On the first day, he wiped it with alcohol a little, and then applied red lotion, but the liquid continued to flow out. On the third day, he began to suppurate, red and swell. Did not take a turn for the better, use powder of the present invention to sprinkle on affected part, every day 3 times, take a turn for the better day by day, stop medication after incrustation, cure after 15 days.

Dong, female, 43 years old, cut her hand with a knife, redness and swelling around the wound after hemostasis, no obvious effect after being coated with wanhua oil for 2 days, use the powder of the present invention, apply it to the affected part every day, 3 times a day, after 2 days of treatment, The redness and swelling disappeared, and the scab wound fell off after 15 days and was cured.

Wang, female, 38 years old, festered between the fingers, severe itching, and later developed ulceration, redness and swelling around the fingernails. After applying some ointments, the symptoms were not significantly relieved; using the composition of the present invention, the composition powder Sprinkle it on the festered part, smear the composition paste on the red and swollen part, 3 times a day, the itching disappears after 2 days, and the festered wound disappears after 10 days of use.

Claims (10)

1. an external Chinese medicine composition for the treatment of swelling and pain, incision wound and skin ulceration, characterized in that, said external Chinese medicine composition is prepared by processing the bulk drug of the following parts by weight: 2. the external Chinese medicine composition for the treatment of swelling and pain as claimed in claim 1, incision wound and skin ulceration, is characterized in that, described external Chinese medicine composition is prepared through processing by the crude drug of following weight part: 3. the external Chinese medicine composition for the treatment of swelling and pain as claimed in claim 2, incision wound and skin ulceration, is characterized in that, described external Chinese medicine composition is prepared through processing by the crude drug of following weight part: 4. the preparation prepared by the external Chinese medicine composition and auxiliary materials for the treatment of swelling and pain, incision wound and skin ulceration described in any one of claims 1-3, is characterized in that, described preparation comprises powder, tincture, spray, Patches, pastes and ointments, the weight ratio of the traditional Chinese medicine composition for external use and auxiliary materials is 1:0.1-12. 5. The preparation according to claim 4, wherein the preparation is a paste, and the auxiliary material is composed of the following parts by weight: 50-60 degrees of white wine or 60-70 degrees of medical alcohol 100- 120 parts, 2-3 parts of sodium benzoate. 6. The preparation according to claim 4, wherein the preparation is an ointment, and the adjuvant is composed of the following components by weight fraction: 20 parts of stearic acid, 26 parts of beeswax, 15 parts of stearyl alcohol, glycerin 20 parts, 1.5 parts of sucrose fatty acid ester, 2 parts of polyoxyethylene castor oil, 1 part of benzalkonium bromide, 2.4 parts of limonene and 80 parts of purified water. 7. a preparation method of the external Chinese medicine composition for the treatment of swelling and pain, incision wound and skin ulceration as described in any one of claims 1-3, said method is: the crude drug of described weight part is pulverized respectively into a coarse powder, dry the coarse powder in an oven at 60°C for 240 minutes, mix and crush the coarse powder, pass through an 80-mesh sieve, and grind into a fine powder, which is a traditional Chinese medicine composition for external use. 8. a preparation method of the external Chinese medicine composition for the treatment of swelling and pain, incision wound and skin ulceration as described in any one of claims 1-3, said method may further comprise the steps: a) dissolving the nitrate in said weight portion with hot water, centrifuging, cooling to precipitate crystals, pulverizing through an 80-mesh sieve to obtain crystal powder; b) Take the Herba Asarum, Rhubarb, Schizonepeta and Atractylodes Rhizoma Atractylodis in said weight parts and add ethanol to reflux for three times, add 10 times the amount of 90% ethanol for the first time, and reflux for 3 hours; add 7 times the amount of 90% ethanol for the second time , reflux extraction for 2 hours; add 4 times the amount of 90% ethanol for the third time, reflux extraction for 1 hour; combine the reflux liquid, filter, and combine to obtain solution 1; c) decoct the perilla, mint, windproof, bletilla striata and licorice for 2 times, the first time decoct 15 times the amount of water for 4 hours, the second time 10 times the amount of water for 1.5 hours, and combine the filtrates , concentrated at a temperature of 55°C to a relative density of 1.00-1.15g/ml, cooled, added 60-70% ethanol, stood for 24 hours, filtered, and the filtrate was concentrated at a temperature of 55°C to a relative density of 1.00- 1.25g/ml thick paste, add water to 60% of the total amount, let it stand for 20 hours, take the supernatant, and obtain solution 2; d) Mix solution 1 and solution 2 evenly, and vacuum-dry at a temperature of 50°C and a pressure of -0.05MPa to obtain a fine powder; e) mixing the crystal powder in step a) and the fine powder in step d) evenly to obtain an external Chinese medicine composition for treating swelling, pain, incision wound and skin ulcer. 9. a preparation method of the preparation as claimed in claim 6, is characterized in that, described method comprises the following steps: a) preparing a traditional Chinese medicine composition for external use, for subsequent use; b) Take the stearic acid, beeswax and stearyl alcohol in the stated parts by weight, heat in a water bath at a temperature of 70-90° C., stir until fully melted, and form an oil phase; c) Take the composition of step a), glycerin, sucrose fatty acid ester, polyoxyethylene castor oil, benzalkonium bromide, and limonene in a water bath, dissolve in purified water, and heat to 70-90°C to form an aqueous phase; d) Slowly pour the oil phase in step b) into the oil phase in step c), and stir while adding, until it cools to 45°C, continue stirring, and fill to obtain an ointment. 10. the external Chinese medicine composition for the treatment of swelling and pain, incision wound and skin ulceration as described in any one of claim 1-3, it is characterized in that, described external Chinese medicine composition is in preparation treatment lymph node inflammation, bee sting, Application in medicine for bruises, knife wounds and skin ulcers.