CN104546476A - Dry granulating method of veterinary Chinese herbal granules - Google Patents
Dry granulating method of veterinary Chinese herbal granules Download PDFInfo
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- CN104546476A CN104546476A CN201510040675.3A CN201510040675A CN104546476A CN 104546476 A CN104546476 A CN 104546476A CN 201510040675 A CN201510040675 A CN 201510040675A CN 104546476 A CN104546476 A CN 104546476A
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- 239000008187 granular material Substances 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 28
- 239000003814 drug Substances 0.000 claims abstract description 57
- 229940079593 drug Drugs 0.000 claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 23
- 238000001035 drying Methods 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 9
- 239000007921 spray Substances 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 241001465754 Metazoa Species 0.000 claims description 18
- 238000007908 dry granulation Methods 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 13
- 238000005507 spraying Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000000047 product Substances 0.000 abstract description 12
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 235000008216 herbs Nutrition 0.000 abstract 1
- 239000010231 banlangen Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 239000011230 binding agent Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 235000019640 taste Nutrition 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000009636 Huang Qi Substances 0.000 description 4
- 238000005550 wet granulation Methods 0.000 description 4
- 239000004375 Dextrin Substances 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 235000019425 dextrin Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000007779 soft material Substances 0.000 description 2
- 241001061264 Astragalus Species 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- -1 mixing Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a dry granulating method of veterinary Chinese herbal granules. The method includes the steps of S10, decocting veterinary Chinese herbs in a pot to obtain extract; S20, settling the extract, filtering the extract to obtain filtrate, concentrating the filtrate with a concentrator pot to concentrated solution with relative density 1.1 to 1.3; S30, drying the concentrated solution with a spray dryer, and crushing a dried product with a crusher to obtain fine powder; S40, granulating the fine powder with a dry granulator to obtain the veterinary Chinese herbal granules. The method has the advantages that the process is simple, a production cycle is short and the veterinary Chinese herbal granules have high content of raw drugs.
Description
Technical field
The present invention relates to veterinary drug preparation technology, particularly relate to a kind of Chinese medicinal granule for animals dry granulation method.
Background technology
Veterinary Chinese medicine of the prior art all adopts wet granulation technology to prepare, its preparation method comprises the following steps: concentrated after being decocted by Chinese medicine crude drug, then binding agent (sucrose, dextrin etc.) is added, after mix homogeneously, soft material processed, wet granular processed, then wet grain drying and the several process of granulate.There is following shortcoming in this preparation technology: 1, binder dosage is large, makes the finished product Central Plains medicine content that obtains low, in addition, because binder dosage greatly not only causes material waste, also add production cost; 2, preparation technology is loaded down with trivial details, and process cycle is long, and cost is high.
Summary of the invention
The present invention seeks to the technical problem for existing in above-mentioned prior art, providing a kind of Chinese medicinal granule for animals dry granulation method, the Chinese medicine granules prepared by the method former medicine content is high, and the method has technique simply, the advantage that the cycle is short.
Chinese medicinal granule for animals dry granulation method of the present invention, comprises the following steps:
S10, each crude drug Chinese medicine extracting tank of veterinary Chinese medicine decocted and extracts to obtain extracting solution;
S20, extracting solution precipitated and after filtering filtrate, by filtrate with concentration tank be concentrated into relative density 1.1 ~ 1.3 concentrated solution;
S30, concentrated solution spray dryer is carried out drying after, pulverize to obtain fine powder with pulverizer;
S40, gained fine powder dry granulating machine is carried out Chinese medicinal granule for animals of granulating to obtain.
Preferably, in order to fully can extract the composition in medical material, step S10 is specially: each crude drug Chinese medicine extracting tank of veterinary Chinese medicine is decocted three times, add the water of crude drug 7 ~ 9 times amount for the first time, boil rear constant temperature 1.5 ~ 2.5 hours, second time adds the water of crude drug 5 ~ 7 times amount, boils rear constant temperature 1.5 ~ 2.5 hours, the water that third time adds crude drug 2 ~ 4 times amount, boils rear constant temperature 0.8 ~ 1.5 hour.
Preferably, in order to fully can extract the composition in medical material, in step S10, when each crude drug Chinese medicine extracting tank of veterinary Chinese medicine extracts, low whipping speed 30r/min condition is carried out.
Preferably, in order to faster and better concentrates, in step S20, filtrate is concentrated into relative density 1.1 ~ 1.3 with concentration tank in pressure 1 ~ 2Mpa, temperature with concentration tank under 85 ~ 95 DEG C of conditions and obtains concentrated solution.
Preferably, in order to shorten drying time, and obtain good drying effect, in step S30, when concentrated solution spray dryer is carried out drying, concentrated solution preheat temperature 40 ~ 60 DEG C, inlet temperature 170 ~ 190 DEG C, material feeding flow at 80 ~ 90kg/ hour, leaving air temp 80 ~ 90 DEG C, wind carries out spraying dry under sending temperature 45 ~ 55 DEG C of conditions and obtains dried fine powder, biodiversity content less than 4% in fine powder.
Preferably, in order to more easily granulate, in step S30, pulverize to obtain fine powder with 120 order pulverizers.
Preferably; in step S40; in order to granulate more smoothly; when being granulated by gained fine powder dry granulating machine, the pinch roller pressure of dry granulating machine is 2 ~ 5Mpa; feeding speed 30 ~ 60 revs/min; pinch roller rotating speed 10 ~ 25 revs/min, broken speed 150 ~ 350 revs/min, granular size is set to 16 ~ 20 orders.
Preferably; in step S40; after being granulated with dry granulating machine by gained fine powder, sieve gets 16 ~ 20 object granules, and all the other granules return dry granulating machine and again granulate; after again granulating; sieve gets 16 ~ 20 object granules again, and all the other granules return dry granulating machine and again granulate, repeatable operation 3 ~ 4 times; with obtained granularity at 16 ~ 20 object granules, do not waste material.
The application dry process Chinese medicinal granule for animals of Chinese medicinal granule for animals dry granulation method initiative of the present invention, preparation method has the following advantages:
1, not easily dry after solving wet granulation, granulation supplementary product consumption is large, finished product contains the low shortcoming of former dose, Chinese medicinal granule for animals dry granulation method of the present invention is by the control of each process parameter, make not need to add the adjuvants such as binding agent in pelletization, therefore dry granulation can improve the former medicine content in granule greatly, and when giving domestic animal medication, overall spice and medicine feed workload reduce.
2, eliminate the processes such as mixing soft material processed, wet granular processed, wet grain drying, granulate, shorten process route and production cycle, in addition due to without adjuvants such as binding agents, avoid the waste of material, also further save cost.
Detailed description of the invention
Describe the present invention below in conjunction with specific embodiment, it should be noted that, these embodiments only should not be construed as limitation of the present invention for illustration of the present invention.
Embodiment 1
The preparation of the blue or green granule of plate
Prescription: Radix Isatidis 60kg Folium Isatidis 90kg.
Wet granulation comparative example: above two taste medicines decoct with water twice, each one hour, collecting decoction, filter, filtrate is concentrated into paste, adds binding agent (sucrose, dextrin) appropriate, and mixing, makes granule, dry, makes 150kg, to obtain final product.After measured, 1g finished product is equivalent to Radix Isatidis crude drug in whole 0.4g, Folium Isatidis crude drug in whole 0.6g.
Prescription: Radix Isatidis 60kg Folium Isatidis 90kg.
Shop floor control humidity is between 35% ~ 55%, and temperature is at 18 ~ 26 DEG C.
Dry granulation: Chinese herbal medicine Radix Isatidis 60kg Folium Isatidis 90kg is mixed the above medicinal 3 cubic metres of Chinese medicine extracting tanks of 2 tastes and boil 3 times, first adds crude drug 8 times amount (by weight respectively to third time, lower same), 6 times amount, the water of 3 times amount, first rises rear constant temperature 2 hours to boiling respectively for the third time, 2 hours, 1 hour, then the concentration tank being added to 3 cubic metres after three well-done medicinal liquid sedimentation and filtrations, at pressure 1Mpa, temperature is carried out being concentrated into relative density 1.1 and is obtained concentrated solution under 85 DEG C of conditions, then the spraying holding vessel of 1 cubic metre is added, spraying dry is carried out with the spray dryer of LPG50 type, time dry, concentrated solution preheat temperature 40 DEG C, inlet temperature 170 DEG C, material feeding flow is at 80kg/ hour, leaving air temp 80 DEG C, wind carries out spraying dry and obtains dried fine powder 30kg under sending temperature 45 C condition, biodiversity content 4% in fine powder.Then after pulverizing with 120 object disintegrating machines, the dry granulating machine enabling GL-100 is again granulated, the pinch roller pressure of dry granulating machine is 2Mpa, feeding speed 30 revs/min, pinch roller rotating speed 10 revs/min, broken speed 150 revs/min, granular size 16 ~ 20 order, sieve gets 16 ~ 20 object granules, and rest materials continues to granulate; Sieve gets 16 ~ 20 object granules again, and rest materials continues to granulate; Repeatable operation three to four times, qualified rear subpackage gets product.After measured, 1g finished product is equivalent to Radix Isatidis crude drug in whole 2g, Folium Isatidis crude drug in whole 3g, has the advantage that former medicine content is high.
Embodiment 2
The preparation of the blue or green granule of plate
Prescription: Radix Isatidis 60kg Folium Isatidis 90kg.
Shop floor control humidity is between 35% ~ 55%, and temperature is at 18 ~ 26 DEG C.
Dry granulation: Chinese herbal medicine Radix Isatidis 60kg Folium Isatidis 90kg is mixed the above medicinal 3 cubic metres of Chinese medicine extracting tanks of 2 tastes and boil 3 times, first adds crude drug 7 times amount respectively to third time, 5 times amount, the water of 2 times amount, first rises rear constant temperature 1.5 hours to boiling respectively for the third time, 1.5 hour, 0.8 hour, then the concentration tank being added to 3 cubic metres after three well-done medicinal liquid sedimentation and filtrations, at pressure 2Mpa, temperature is carried out being concentrated into relative density 1.3 and is obtained concentrated solution under 95 DEG C of conditions, then the spraying holding vessel of 1 cubic metre is added, spraying dry is carried out with the spray dryer of LPG50 type, time dry, concentrated solution preheat temperature 60 DEG C, inlet temperature 190 DEG C, material feeding flow is at 90kg/ hour, leaving air temp 90 DEG C, wind carries out spraying dry under sending temperature 55 DEG C of conditions and obtains dried fine powder 29.5kg, biodiversity content 3% in fine powder.Then after pulverizing with 120 object disintegrating machines, the dry granulating machine enabling GL-100 is again granulated, the pinch roller pressure of dry granulating machine is 5Mpa, feeding speed 60 revs/min, pinch roller rotating speed 25 revs/min, broken speed 350 revs/min, granular size 16 ~ 20 order, sieve gets 16 ~ 20 object granules, and rest materials continues to granulate; Sieve gets 16 ~ 20 object granules again, and rest materials continues to granulate; Repeatable operation three to four times, qualified rear subpackage gets product.After measured, 1g finished product is equivalent to Radix Isatidis crude drug in whole 2g, Folium Isatidis crude drug in whole 3g, has the advantage that former medicine content is high.
Embodiment 3
Stilbene chastity increases exempts from granule
Prescription: Radix Astragali 180kg Herba Epimedii 90kg Fructus Ligustri Lucidi 90kg.
Wet granulation comparative example: above 3 tastes, decoct with water three times, collecting decoction, filter, filtrate is concentrated about to 360ml, adds 3 times amount ethanol, 4 DEG C leave standstill 24 hours, filter, filtrate recycling ethanol, be concentrated into the clear paste that relative density is 1.30 ~ 1.35 (80 DEG C), by clear paste amount with sucrose 3 parts, 1 part, dextrin, mixing, granulates, cold drying, make 300kg granule, to obtain final product.After measured, 1g finished product is equivalent to Radix Astragali crude drug in whole 0.6g, Herba Epimedii crude drug in whole 0.3g, Fructus Ligustri Lucidi crude drug in whole 0.3g.
Prescription: Radix Astragali 180kg Herba Epimedii 90kg Fructus Ligustri Lucidi 90kg.
Shop floor control humidity is between 35% ~ 55%, and temperature is at 18 ~ 26 DEG C.
Dry granulation: by Chinese herb astragalus 180kg, Herba Epimedii 90kg, the medicinal 3 cubic metres of Chinese medicine extracting tanks of more than Fructus Ligustri Lucidi 90kg 3 taste boil 3 times, first adds crude drug 9 times amount respectively to third time, 7 times amount, the water of 4 times amount, first rises rear constant temperature 2.5 hours to boiling respectively for the third time, 2.5 hour, 1.5 hour, then the concentration tank being added to 3 cubic metres after three well-done medicinal liquid sedimentation and filtrations, at pressure 2Mpa, temperature is carried out being concentrated into relative density 1.2 and is obtained concentrated solution under 90 DEG C of conditions, again concentrated solution is added the spraying holding vessel of 1 cubic metre, spraying dry is carried out with the spraying dry machine of LPG50 type, time dry, concentrated solution preheat temperature 50 DEG C, inlet temperature 180 DEG C, material feeding flow is at 85kg/ hour, leaving air temp 85 DEG C, wind carries out spraying dry and obtains dried fine powder 72kg under sending temperature 50 C condition, biodiversity content 4% in fine powder.Fine powder 120 object disintegrating machines are pulverized, then the dry granulating machine enabling GL-100 is granulated, the pinch roller pressure of dry granulating machine is 4Mpa, feeding speed 50 revs/min, pinch roller rotating speed 20 revs/min, broken speed 300 revs/min, granular size 16 ~ 20 order, sieve gets 16 ~ 20 object granules, and rest materials continues to granulate; Sieve gets 16 ~ 20 object granules again, and rest materials continues to granulate; Repeatable operation three to four times, qualified rear subpackage gets product.After measured, 1g finished product is equivalent to Radix Astragali crude drug in whole 2.5g, Herba Epimedii crude drug in whole 1.25g, Fructus Ligustri Lucidi crude drug in whole 1.25g, has the advantage that former medicine content is high.
Chinese medicine extracting tank used in above embodiment, concentration tank, spray dryer, pulverizer and dry granulating machine are existing equipment.
The sequencing of above embodiment, only for ease of describing, does not represent the quality of embodiment.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (8)
1. a Chinese medicinal granule for animals dry granulation method, is characterized in that, comprises the following steps:
S10, each crude drug Chinese medicine extracting tank of veterinary Chinese medicine decocted and extracts to obtain extracting solution;
S20, extracting solution precipitated and after filtering filtrate, by filtrate with concentration tank be concentrated into relative density 1.1 ~ 1.3 concentrated solution;
S30, concentrated solution spray dryer is carried out drying after, pulverize to obtain fine powder with pulverizer;
S40, gained fine powder dry granulating machine is carried out Chinese medicinal granule for animals of granulating to obtain.
2. Chinese medicinal granule for animals dry granulation method according to claim 1, is characterized in that,
Step S10 is specially: each crude drug Chinese medicine extracting tank of veterinary Chinese medicine is decocted three times, add the water of crude drug 7 ~ 9 times amount for the first time, boil rear constant temperature 1.5 ~ 2.5 hours, second time adds the water of crude drug 5 ~ 7 times amount, boil rear constant temperature 1.5 ~ 2.5 hours, the water that third time adds crude drug 2 ~ 4 times amount, boils rear constant temperature 0.8 ~ 1.5 hour.
3. Chinese medicinal granule for animals dry granulation method according to claim 1, is characterized in that, in step S10, when each crude drug Chinese medicine extracting tank of veterinary Chinese medicine extracts, low whipping speed 30r/min condition is carried out.
4. Chinese medicinal granule for animals dry granulation method according to claim 1, is characterized in that, in step S20, filtrate is concentrated into relative density 1.1 ~ 1.3 with concentration tank in pressure 1 ~ 2Mpa, temperature with concentration tank under 85 ~ 95 DEG C of conditions and obtains concentrated solution.
5. Chinese medicinal granule for animals dry granulation method according to claim 1, it is characterized in that, in step S30, when concentrated solution spray dryer is carried out drying, concentrated solution preheat temperature 40 ~ 60 DEG C, inlet temperature 170 ~ 190 DEG C, material feeding flow is at 80 ~ 90kg/ hour, leaving air temp 80 ~ 90 DEG C, wind carries out spraying dry under sending temperature 45 ~ 55 DEG C of conditions and obtains dried fine powder, biodiversity content less than 4% in fine powder.
6. Chinese medicinal granule for animals dry granulation method according to claim 1, is characterized in that, in step S30, pulverizes to obtain fine powder with 120 order pulverizers.
7. Chinese medicinal granule for animals dry granulation method according to claim 1; it is characterized in that; in step S40; when gained fine powder dry granulating machine is granulated; the pinch roller pressure of dry granulating machine is 2 ~ 5Mpa, feeding speed 30 ~ 60 revs/min, pinch roller rotating speed 10 ~ 25 revs/min; broken speed 150 ~ 350 revs/min, granular size is set to 16 ~ 20 orders.
8. Chinese medicinal granule for animals dry granulation method according to claim 1; it is characterized in that; in step S40; after being granulated with dry granulating machine by gained fine powder, sieve gets 16 ~ 20 object granules, and all the other granules return dry granulating machine and again granulate; after again granulating; sieve gets 16 ~ 20 object granules again, and all the other granules return dry granulating machine and again granulate, repeatable operation 3 ~ 4 times.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800293A (en) * | 2015-05-14 | 2015-07-29 | 胡少平 | Veterinary codonopsis pilosula and astragalus immunity improving Chinese medicine preparation |
| CN107041902A (en) * | 2016-10-31 | 2017-08-15 | 四川美嘉龙生物科技有限公司 | A kind of stilbene chastity, which increases, exempts from particle and preparation technology |
| CN107961330A (en) * | 2018-01-17 | 2018-04-27 | 保定冀中药业有限公司 | A kind of preparation method of the five tastes for animals particle green for a long time |
| CN110882304A (en) * | 2019-12-02 | 2020-03-17 | 广东容大生物股份有限公司 | Method for preparing astragalus root and glossy privet fruit medicine for livestock and poultry |
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Application publication date: 20150429 |
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| RJ01 | Rejection of invention patent application after publication |