CN104530489B - A kind of starch film-forming composition for being instantly dissolved in water - Google Patents
A kind of starch film-forming composition for being instantly dissolved in water Download PDFInfo
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- CN104530489B CN104530489B CN201510059416.5A CN201510059416A CN104530489B CN 104530489 B CN104530489 B CN 104530489B CN 201510059416 A CN201510059416 A CN 201510059416A CN 104530489 B CN104530489 B CN 104530489B
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- 229920002472 Starch Polymers 0.000 title claims abstract description 61
- 239000008107 starch Substances 0.000 title claims abstract description 61
- 235000019698 starch Nutrition 0.000 title claims abstract description 61
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 7
- 235000013305 food Nutrition 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 238000012856 packing Methods 0.000 claims abstract description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 238000001125 extrusion Methods 0.000 claims description 7
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 7
- 238000005453 pelletization Methods 0.000 claims description 6
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 4
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 abstract description 9
- 238000004090 dissolution Methods 0.000 abstract description 8
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 11
- 229920000881 Modified starch Polymers 0.000 description 9
- 235000019426 modified starch Nutrition 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 239000004368 Modified starch Substances 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 239000012467 final product Substances 0.000 description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 230000008676 import Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 125000005113 hydroxyalkoxy group Chemical group 0.000 description 2
- 235000021539 instant coffee Nutrition 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 229920000945 Amylopectin Polymers 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Chemical class 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 125000005111 carboxyalkoxy group Chemical group 0.000 description 1
- -1 carboxyethyl Chemical group 0.000 description 1
- 229920002678 cellulose Chemical class 0.000 description 1
- 239000001913 cellulose Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 125000003071 maltose group Chemical group 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Chemical class 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
The invention discloses a kind of starch film-forming composition for being instantly dissolved in water, comprising water soluble starch and water soluble adjuvant, the auxiliary material can be used for the inner packing of the film, the capsule of encasing food or medicine and directly contact food or medicine that prepare load-bearing functionality material, fast, the controllable advantage of concentration after dissolving with dissolution velocity.
Description
Technical field
The present invention relates to a kind of starch film-forming composition for being instantly dissolved in water, starch derivatives field is related particularly to
And application.
Background technology
Starch is that glucose molecule is polymerized, and it is the most common storage form of carbohydrate in cell, hydrolysis
It is maltose to the disaccharides stage, glucose is obtained after complete hydrolysis.
Starch has amylose and the class of amylopectin two.The former is branchiess helical structure；The latter is with 24 ~ 30 grapes
Saccharide residue is joined end to end and is formed with α-Isosorbide-5-Nitrae-glycosidic bond, is α -1,6- glycosidic bonds at side chain.Starch is storage in plant
Nutrient, is stored in seed and stem tuber, and the content of starch in all kinds of plants is all higher.
Native starch is not dissolved in cold water, is gelatinized in the hot water, and form sticky liquid.This process often takes
It is more long.Starch through it is certain it is modified after, the active force between internal each molecule chain can be weakened, while increasing the parent to water
With ability improving its solubility in cold water.
At present, most common water soluble starch has hydroxypropul starch and sodium carboxymethyl starch on the market：
Hydroxypropul starch is under strongly alkaline conditions, to be obtained with propylene oxide reaction by starch, with good water solubility,
Its aqueous solution clear, colorless, good stability；
Carboxyrnethyl starch sodium is a kind of anion starch ether, is the electrolyte that can be dissolved in cold water, it is tasteless, nontoxic, be difficult to go mouldy,
It is soluble in water and form colloidal solution when substitution value is more than more than 0.2, to light, thermally-stabilised.Insoluble in ethanol, ether, chlorine
It is imitative to wait organic solvent.The product aqueous solution is relatively stablized in alkali, poor in acid, generates water insoluble free acid, viscosity reduction.
Although the two belongs to water miscible starch, dissolution velocity is undesirable, generally requires more than 10 minutes ability
It is completely dissolved.
Instant material refers to the class material that diffusion can be rapidly disintegrated, dissolved in cold water, is widely used in food and medicine
Product are manufactured, such as instant, instant coffee, quick-release capsules, dissolving tablet.Common, instant material is by water soluble polymer
Material is made, such as cyclodextrin, polyvinyl alcohol, cellulose derivative, instant for what is be made using starch or starch derivatives
Material report is less.
The A of Chinese patent CN 1784218 are disclosed and a kind of are suitable in the warm-blooded animal oral cavity including people adhesion and molten
The consumable film of solution, including modified starch, pharmaceutically active agents and optionally at least one water-soluble polymer.The patent reality
On there is provided a kind of oral administration mode, will pharmaceutically active agents and starch and auxiliary material be made a kind of consumable film, institute
Stating film can rapidly dissolve in warm-blooded animal oral cavity, and stick on mucous membrane of mouth, while by drug delivery to mucous membrane.But should
Patent does not disclose the dissolution time of the film, and the film has larger viscosity upon dissolution, although be conducive to attachment
Oral administration, but this feature limits the film other field application.
The content of the invention
The invention provides a kind of starch film-forming composition for being instantly dissolved in water, with the fater disintegration in water, dissolving, and
The characteristics of resulting solution viscosity is controllable.
First, the invention provides a kind of starch film-forming composition for being instantly dissolved in water, its component comprising water soluble starch and
Water soluble adjuvant, it is characterised in that the water soluble starch is water-soluble modified starch, and the weight of the water soluble adjuvant is water
The 0.001%-1% of soluble starch, preferably 0.01%-0.05%.
Further, the water-soluble modified starch is the starch derivatives in structure with free hydroxyl or carboxyl,
Described water soluble adjuvant is with free hydroxyl or carboxyl macromolecular compound.
Further, the water soluble starch is selected from hydroxy alkoxy base starch, the alternative one of Carboxyalkoxy starch, institute
State water soluble adjuvant and be selected from polyethylene glycol, sodium carboxymethylcellulose.
Further, the hydroxy alkoxy base starch is selected from the one kind in hydroxypropul starch, HES, the carboxyl
Alkoxy starch is selected from the one kind in CMS, carboxyethyl starch.
The described starch film-forming composition for being instantly dissolved in water, is made up of, hydroxypropul starch the component of following weight
50-150 weight portions, sodium carboxymethylcellulose 0.1-2 weight portions, PEG400 and the 0.01-2 weight of 0.01-2 weight portions
Measure the Macrogol 4000 of part.
Combinations of the above thing has the ability of the rapid dissolving in 15-40 DEG C of water.By the species to wherein each component and
The screening of consumption, this dissolution time can be controlled between 10s ~ 90s.The species or specification for changing water soluble starch can be adjusted
Dissolution time of the section material in water, regulation supplementary product consumption can control the viscosity of solution, can also aid in change dissolution time.
Water soluble starch can typically use low degradable starch or water-soluble modified starch.Low degradable starch is the part of starch
Degraded hydrolysate, is obtained by Controlled-enzymatic Hydrolysis or controlling fermentation.Because molecular weight is smaller than native starch, chain is short, the degree of branching
It is low, therefore water-soluble is better than native starch, it is adaptable to the less demanding material of filming performance.
In a class preferred scheme, water-soluble modified starch is from the starch derivatives in structure with free hydroxyl or carboxyl
Biology, water soluble adjuvant is from free hydroxyl or carboxyl macromolecular compound.This is due to the water-soluble modified shallow lake
The hydroxyl or carboxyl of powder have strong hydrophilicity ability, and water energy enough destroys its molecular structure quickly, promote expansion, the disintegration, institute of material
Stating auxiliary material can increase degree of scatter of the starch in water, while the internal resistance of starch solution is reduced, so as to reach reduction solution
The purpose of viscosity.
Composition of the present invention can be used for the manufacture of film class product, for example：The film of load medicine, patch in oral cavity, with
The packaging of food or medicine directly contact（Such as the film of confection exterior）, instant food or quick-release pharmaceutical packing bag（It is such as instant
Coffee flour bag or instant milk tea flour bag, quick-release capsules）Deng.
The manufacture of the film refers to any one film forming process in the prior art to be carried out, such as blow moulding, pressing, coating
Method etc., only need on demand feed intake the film-forming composition that the present invention is provided, then coordinate corresponding manufacturing process.
The present invention is better understood from for convenience of technical staff, in one embodiment that the application is recorded, there is provided a kind of
The manufacture method of feasible film.
On the other hand, composition of the present invention, its existence form can be powder, particle or small pieces, with composition
Manufacture method it is relevant.
It is common, the raw material dry powder is pressed into prescription input high-speed mixer, can be obtained through fully mixing.And
If necessary, water soluble adjuvant wiring solution-forming can by several times be added.
Other, water soluble starch and water soluble adjuvant being made into weak solution, can be also obtained using spray technique.
To obtain the film-forming composition of more high-quality, present invention also offers a kind of preferably fabricated side of the composition
Method.Manufactured using extruder, including step：Premix, feed intake, extruding, pelletizing, drying.Wherein, extruder is with 6 heating
The double screw extruder of sliding block, screw slenderness ratio is 15-35：1, each sliding block temperature is controlled respectively, in 60-150 degrees Celsius, screw rod
Rotating speed is 100-300 rpm.In the 2nd sliding block to water delivery in extruder, the 3rd sliding block input water soluble adjuvant, the exhaust of the 5th sliding block.
Using the film-forming composition transparency described in extruder acquisition preferably, good appearance after film forming and encystation, is adapted to expensive goods
Manufacture.
The present invention is advantageous in that：
1. a kind of new instant material is provided, current production species is enriched, for the manufacture of downstream product is provided newly
Selection.
2. said material has the advantage that dissolution velocity is controllable, viscosity is controllable, expands the scope of application, material is applied
In various different fields.
Specific embodiment
Following embodiment is only better understood from the present invention as help technical staff, not as any type of to this
The further restriction of invention.Those skilled in the art carry out limited improvement on the basis of embodiment should be also considered as in this hair
In bright protection domain.
Embodiment 1
Low degradable starch 100kg
Macrogol 4000 1g
1g Macrogol 4000s are made into the aqueous solution of 1L.Low degradable starch puts into high-speed mixer, under agitation will be poly-
The aqueous solution of ethylene glycol 4000 is added by several times, is at least stirred 3 hours, is obtained final product.
Embodiment 2
Low degradable starch 100kg
Polyacrylic acid 10g
By low degradable starch and polyacrylic acid difference wiring solution-forming, wherein sinking solution starch solution mass concentration is 10%, is gathered
Acrylic acid solution is 0.1%, is mixed the two using sprayer, is drying to obtain.
Embodiment 3
Hydroxypropul starch 100kg/h（Charging rate）
Macrogol 4000 50g/h（Charging rate）
Step
Extruder parameter is：Screw slenderness ratio 15：1, rotating speed 200rpm, import and export and each sliding block temperature is respectively：
Charging aperture：Room temperature,
Sliding block 1：60℃
Sliding block 2：90℃
Sliding block 3：140℃
Sliding block 4：150℃
Sliding block 5：145℃
Sliding block 6：130℃
Outlet：80℃.
Hydroxypropul starch is loaded into extruder hopper, extruder is started, material enters machine barrel under the drive of screw rod, the
2 sliding blocks access Macrogol 4000 feeder to defeated pure water in extruder, the 3rd sliding block, and the 5th sliding block connects vacuum to be vented.Material
Strip is extruded into through mouth mold, pelletizing is obtained final product.
Embodiment 4
CMS 50kg/h（Charging rate）
Sodium carboxymethylcellulose 50g/h（Charging rate）
Step
Extruder parameter is：Screw slenderness ratio 23：1, rotating speed 100rpm, import and export and each sliding block temperature is respectively：
Charging aperture：Room temperature,
Sliding block 1：75℃
Sliding block 2：110℃
Sliding block 3：145℃
Sliding block 4：150℃
Sliding block 5：150℃
Sliding block 6：125℃
Outlet：90℃.
CMS is loaded into extruder hopper, extruder is started, material enters machine barrel under the drive of screw rod, the
2 sliding blocks access sodium carboxymethylcellulose feeder to defeated pure water in extruder, the 3rd sliding block, and the 5th sliding block connects vacuum to be vented.Thing
Material is extruded into strip through mouth mold, and pelletizing is obtained final product.
Embodiment 5
Hydroxypropul starch 100kg/h（Charging rate）
Sodium carboxymethylcellulose 250g/h（Charging rate）
Step
Extruder parameter is：Screw slenderness ratio 23：1, rotating speed 300rpm, import and export and each sliding block temperature is respectively：
Charging aperture：Room temperature,
Sliding block 1：75℃
Sliding block 2：110℃
Sliding block 3：145℃
Sliding block 4：150℃
Sliding block 5：150℃
Sliding block 6：125℃
Outlet：90℃.
CMS is loaded into extruder hopper, extruder is started, material enters machine barrel under the drive of screw rod, the
2 sliding blocks access sodium carboxymethylcellulose feeder to defeated pure water in extruder, the 3rd sliding block, and the 5th sliding block connects vacuum to be vented.Thing
Material is extruded into strip through mouth mold, and pelletizing is obtained final product.
Embodiment 6
Hydroxypropul starch 100kg/h（Charging rate）
PEG400 250g/h（Charging rate）
Macrogol 4000 250g/h（Charging rate）
Step
Extruder parameter is：Screw slenderness ratio 35：1, rotating speed 300rpm, import and export and each sliding block temperature is respectively：
Charging aperture：Room temperature,
Sliding block 1：70℃
Sliding block 2：100℃
Sliding block 3：135℃
Sliding block 4：135℃
Sliding block 5：110℃
Sliding block 6：101℃
Outlet：80℃.
Hydroxypropul starch is loaded into extruder hopper, extruder is started, material enters machine barrel under the drive of screw rod, the
2 sliding blocks access the feeder of polyethylene glycol to defeated pure water in extruder, the 3rd sliding block, and the 5th sliding block connects vacuum to be vented.Material is passed through
Die extrusion strip, pelletizing is obtained final product.
Embodiment 7
Hydroxypropul starch 100kg/h（Charging rate）
PEG400 250g/h（Charging rate）
Macrogol 4000 250g/h（Charging rate）
Sodium carboxymethylcellulose 250g/h（Charging rate）
Preparation method is identical with embodiment 6.
The preparation of the starch film of embodiment 8
The composition that embodiment 1-7 is obtained is respectively fed to single screw extrusion machine, from the die extrusion film forming of 0.25mm.
Viscosity test after the solubility property of embodiment 9 and dissolving
1. the test of solubility property is carried out by the following method：
Film obtained in Example 8, cuts into the diaphragm of the 2cm × 2cm of same thickness.Three 250ml beakers are taken, is added
150ml pure water, first is placed in 20 DEG C of water-baths, and second is placed in 37 DEG C of water-baths, and the 3rd is placed in 37 DEG C of water-baths, while plus
Enter amylase.10 diaphragms are taken again, and two beakers are put into respectively.Start to use manual time-keeping when water did not had diaphragm, to film
It is completely dissolved stopping timing.
2. viscosity test is carried out by the following method after dissolving：
Product and each 15g of commercially available soluble starch that Example 1-6 is obtained, are made into 2% aqueous solution, the traditional Chinese medicines in
It is as a result as follows in the dynamic viscosity at 20 DEG C with determination of ubbelohde viscometer solution in allusion quotation version two in 2010.
Claims (3)
1. a kind of starch film-forming composition for being instantly dissolved in water, it is characterised in that the described starch film-forming composition for being instantly dissolved in water,
It is made up of the component of following weight：Hydroxypropul starch 50-150 weight portions, sodium carboxymethylcellulose 0.1-2 weight portions,
The PEG400 of 0.01-2 weight portions and the Macrogol 4000 of 0.01-2 weight portions；
Its preparation method is comprised the following steps：Dispensing, extrusion, pelletizing, drying, it is characterised in that extrusion operation uses twin-screw
Extruder is carried out.
2. composition according to claim 1, it is characterised in that the extrusion temperature of the extrusion operation is taken the photograph for 60-150
Family name's degree, screw speed is 100-300rpm, and screw slenderness ratio is 15-35：1.
3. the composition described in claim 1-2 any one is preparing the film of load-bearing functionality material, encasing food or medicine
Purposes in the capsule of product and the inner packing of directly contact food or medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510059416.5A CN104530489B (en) | 2015-02-05 | 2015-02-05 | A kind of starch film-forming composition for being instantly dissolved in water |
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| CN201510059416.5A CN104530489B (en) | 2015-02-05 | 2015-02-05 | A kind of starch film-forming composition for being instantly dissolved in water |
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| CN104530489B true CN104530489B (en) | 2017-07-07 |
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| CN108084987A (en) * | 2017-12-25 | 2018-05-29 | 中国石油集团川庆钻探工程有限公司长庆井下技术作业公司 | A kind of natural gas well turnaround fracture microvesicle temporarily blocks up liquid filler and its application |
| CN111533958A (en) * | 2020-05-28 | 2020-08-14 | 佛山市爱地球环保新材料科技有限公司 | A kind of agricultural mulch film with controllable dissolution time and preparation method |
| CN115368617A (en) * | 2022-08-30 | 2022-11-22 | 陕西理工大学 | A special inner packaging material instant film for solid beverage and preparation method thereof |
Citations (1)
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|---|---|---|---|---|
| CN100434462C (en) * | 2001-11-16 | 2008-11-19 | 国家淀粉及化学投资控股公司 | Thin film contg. starch |
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| US6509040B1 (en) * | 2001-06-22 | 2003-01-21 | R.P. Scherer Corporation | Fast dispersing dosage forms essentially free of mammalian gelatin |
| BRPI0409463A (en) * | 2003-05-02 | 2006-05-02 | Warner Lambert Co | fast dissolving orally consumable films containing a modified starch to improve heat and moisture resistance |
| CA2813146C (en) * | 2010-10-08 | 2018-12-18 | R.P. Scherer Technologies, Llc | Oral vaccine fast-dissolving dosage form using starch |
| CN103224652A (en) * | 2013-03-14 | 2013-07-31 | 浙江大学 | Edible instant noodle vegetable bag packaging film and preparation method thereof |
| CN103893771B (en) * | 2014-04-21 | 2015-08-26 | 湖南尔康制药股份有限公司 | A kind of film-forming composition for the production of starch material soft capsule and preparation method thereof |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100434462C (en) * | 2001-11-16 | 2008-11-19 | 国家淀粉及化学投资控股公司 | Thin film contg. starch |
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