CN104510729A - Animal immune resistance-activating composition of fatty acid and derivatives thereof - Google Patents
Animal immune resistance-activating composition of fatty acid and derivatives thereof Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims 12
- 235000014113 dietary fatty acids Nutrition 0.000 title claims 7
- 239000000194 fatty acid Substances 0.000 title claims 7
- 229930195729 fatty acid Natural products 0.000 title claims 7
- 241001465754 Metazoa Species 0.000 title claims 6
- 125000005313 fatty acid group Chemical group 0.000 title 1
- 150000004676 glycans Chemical class 0.000 claims 8
- 229920001282 polysaccharide Polymers 0.000 claims 8
- 239000005017 polysaccharide Substances 0.000 claims 8
- 150000004665 fatty acids Chemical class 0.000 claims 6
- 235000002639 sodium chloride Nutrition 0.000 claims 5
- -1 2-hydroxypropyl Chemical group 0.000 claims 4
- 241001597008 Nomeidae Species 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 150000002484 inorganic compounds Chemical class 0.000 claims 3
- 150000002894 organic compounds Chemical class 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 229920001503 Glucan Polymers 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- 239000000686 essence Substances 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- FGKJLKRYENPLQH-UHFFFAOYSA-N isocaproic acid Chemical compound CC(C)CCC(O)=O FGKJLKRYENPLQH-UHFFFAOYSA-N 0.000 claims 2
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 241000208340 Araliaceae Species 0.000 claims 1
- 241001061264 Astragalus Species 0.000 claims 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- 241000190633 Cordyceps Species 0.000 claims 1
- 241001313734 Dictyophora Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 229920002488 Hemicellulose Polymers 0.000 claims 1
- 239000005639 Lauric acid Substances 0.000 claims 1
- 229920001491 Lentinan Polymers 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 241000180649 Panax notoginseng Species 0.000 claims 1
- 235000003143 Panax notoginseng Nutrition 0.000 claims 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 229920000392 Zymosan Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims 1
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000005466 alkylenyl group Chemical group 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 230000002180 anti-stress Effects 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 229940114079 arachidonic acid Drugs 0.000 claims 1
- 235000021342 arachidonic acid Nutrition 0.000 claims 1
- 235000006533 astragalus Nutrition 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 229910001628 calcium chloride Inorganic materials 0.000 claims 1
- 235000011148 calcium chloride Nutrition 0.000 claims 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims 1
- 239000000292 calcium oxide Substances 0.000 claims 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 1
- 235000012255 calcium oxide Nutrition 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011132 calcium sulphate Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910000365 copper sulfate Inorganic materials 0.000 claims 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 1
- 235000008434 ginseng Nutrition 0.000 claims 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 229940115286 lentinan Drugs 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 235000019691 monocalcium phosphate Nutrition 0.000 claims 1
- 235000019796 monopotassium phosphate Nutrition 0.000 claims 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 claims 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 235000011181 potassium carbonates Nutrition 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 1
- 229910052939 potassium sulfate Inorganic materials 0.000 claims 1
- 235000011151 potassium sulphates Nutrition 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000019830 sodium polyphosphate Nutrition 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 235000011152 sodium sulphate Nutrition 0.000 claims 1
- 235000019832 sodium triphosphate Nutrition 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 210000004233 talus Anatomy 0.000 claims 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 1
- 230000005760 tumorsuppression Effects 0.000 claims 1
- 229940005605 valeric acid Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000004246 zinc acetate Substances 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
- 235000014692 zinc oxide Nutrition 0.000 claims 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 1
- 229910000368 zinc sulfate Inorganic materials 0.000 claims 1
- 229960001763 zinc sulfate Drugs 0.000 claims 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
Provided is a preparation formula prepared by combining fatty acid or fatty acid salts or derivatives thereof with chitosan and the like. The composition has significant effects on enhancing animal immunity resistance, inhibiting tumor growth, enhancing an animal anti-stress ability, increasing animal appetite and promoting animal growth, and has positive significance in reduction of livestock dependence on antibiotics, hormones and the like.
Description
Technical field
The invention belongs to biological technical field, relate to for detoxification or the immune resistance reinforcing agent drunk.
Background technology
The development of modern poultry and aquaculture industry plays a very important role for China's economic development and environment sustainable development.But along with the raising of cultivation intensive degree, the density of the animal cultivation such as poultry and fish shrimp crab is large, adds a large amount of uses of hormone or antibiotic etc., animal growth rate is fast, and the ability of animal anti-stress significantly weakens, and immune resistance is low, be very easy to cause the popular of disease, cause animal mortality.
Stress under environment, the irritability of animal body feeding center reduces, neuroendocrine disorders, and the hormone secretion such as thyroxine, epinephrine is disorderly, degradation under human body immune function.Such as, pig cultivation aspect be mainly manifested in following several respects: 1) feed intake reduces, and grower pigs weightening finish is slowly.2) pig breeding dysfunction is planted.Sow hypo ovaria, miscarriage, conception rate decline, the increase of stillborn fetus number, lactation amount decline, piglet survival ratio reduction etc.; Breeding boar hyposexuality, semen quality decline, sperm quantity minimizing, vigor reduction, abnormal rate rising etc.3) disease such as the dermatitis nephrotic syndrome, baby pig diarrhoea, unknown high fever, chronic ileitis increases.4) meat quality reduces.5) virosis is popular.Then there is the poor growths such as shrimp Eriocheir sinensis, shelling difficulty, disease popularity, mortality in aquatic products.
Traditional method is mainly through adding the anti-stress ability of anti-stress additive as enhancing animals such as fat, synthesizing amino acid, electrolyte, mineral, vitamin and organic acids, or the resistance against diseases by using antibiotic and vaccine to strengthen animal, can play a role.But due to a large amount of uses of these products, not only bring the food-safety problems such as the residue of veterinary drug further received publicity, result also in the day by day serious resistance of pathogenic microorganism and produce, serious challenge is constituted to the development of aquaculture.
In recent years, some experts and scholars start to pay close attention to polysaccharose substance as the effect of anti stress immunity enhancing agent in the Immunoresistance improving animal body both at home and abroad.Domestic and international research finds, polysaccharide such as chitosan can increase the anti-stress immunity of animal, is applied in the feed additive of animal, can strengthen anti-stress ability and the immune resistance of animal.But because the application of single component acts on instability in actual applications, the effect of polysaccharide is not given prominence to, animal occurs that stress or sick rear use then do not have effect.
The compositions that fatty acid and polysaccharide component etc. are made by the present invention, can greatly active cell immunologic function,
Thus raising immunity of organisms, there is treatment animal virus disease, the effect of fungal disease, and the effect with Tumor suppression.
Summary of the invention
Select the fatty acid of one or more following formulas containing 0.01-99.9999%, their ester, their salt or derivant or their mixture:
And/or
In formula, X is H, C
1-C
31alkyl or alkenyl, 2-hydroxyethyl, 2-hydroxypropyl;
Y is H, C
1-C
4alkyl or alkenyl, metal or nonmetalloid or group;
Z is H, OH, C
1-C
4alkyl or alkenyl, metal or nonmetalloid or group;
By above-mentioned fatty acid, their ester, their salt or derivant or their mixture and following any one or Multiple components combination in any before being administered to target site or when being administered to target site, a kind of anion sulfate or sulfosalt surfactant, one or more edible essences, one or more polysaccharide, one or more inorganic or organic compound and one or more high molecular polymers strengthen animal immune resistance by having of being mixed of 0.1-95%, Tumor suppression grows, strengthen animal anti-stress ability, increase animal appetite, promote the compositions of growth of animal, the pH value of described compositions is 2.0-3.9.
The polysaccharide polymer polymer selected is including, but not limited to trehalose, starch, soluble starch, aminopolysaccharide, amino-oligosacchride, chitosan, glycosaminoglycans, chitosan, cellulose, hemicellulose, methylcellulose, sodium carboxymethyl cellulose, Cordyceps polysaccharide, astragalus polysaccharides, ginseng polysaccharide, Radix Notoginseng polysaccharide, dictyophora fungus polysaccharide, ganoderan, lentinan, zymosan etc.
The fatty acid selected and fatty acid ester or derivant are the saturated or undersaturated fatty acids from C2 to C28, including, but not limited to acetic acid, and diacetic acid, butanoic acid, isopropylformic acid., valeric acid, isovaleric acid, caproic acid, isocaproic acid, certain herbaceous plants with big flowers acid, sad, Palmic acid, palmitic olefinic acid, stearic acid, linoleic acid, oleic acid, linolenic acid, lauric acid, myristic acid, n-nonanoic acid, arachidonic acid etc., and the salt that these fatty acids are made.
The organic or inorganic compound selected including, but not limited to calcium chloride, sodium chloride, potassium chloride, zinc oxide, calcium oxide, calcium superphosphate, Sodium triphosphate, sodium bicarbonate, sodium polyphosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, sodium sulfate, zinc sulfate, copper sulfate, zinc acetate, potassium sulfate, calcium carbonate, amino acid calcium, amino-acid zinc, glucosan calcium, glucosan zinc, sodium carbonate, calcium bicarbonate, potassium bicarbonate, calcium sulfate, lime nitrate, calisanin, potassium carbonate etc.
Fatty acid, their ester, their salt or derivant, polysaccharide high molecular polymer and surfactant etc. are added to the water, edible essence and inorganic or organic compound is added respectively, with inorganic or organic acid or alkali adjustment compositions pH value under constantly stirring.
The technical problem that the present invention solves is fatty acid or derivatives thereof and the polysaccharide high molecular polymer compositions made at pH2.0 to pH4.9, this compositions is for enhancing animal immune resistance, Tumor suppression grows, strengthen animal anti-stress ability, increase animal appetite, promote that growth of animal has remarkable result.
Specific embodiments
The present invention is further described according to following example, one skilled in the art will appreciate that following embodiment only plays the effect of explanation to the present invention.Without departing from the premise in the spirit of the present invention, any improvement the present invention done and substituting all in the scope of protection of the invention.
Embodiment one
Peracetic acid formulation is become 0.5% aqueous solution, getting chitosan 10g joins in 500ml 0.5% acetic acid aqueous solution, add dipotassium hydrogen phosphate 2g respectively, ammonium sulfate 5g, Sodium triphosphate 5g, glucosan calcium 8g, sodium alkyl sulfate 0.1g and stearic acid 2.5g, stir, regulate the pH value of solution to 2.9.Make compositions one.
Embodiment two
Butanoic acid is mixed with 0.5% aqueous solution, getting chitosan 10g joins in 500ml 0.5% butanoic acid aqueous solution, add potassium dihydrogen phosphate 3g, potassium sulfate 5g, Sodium triphosphate 10g, amino-acid zinc 3g, sodium alkyl sulfate 0.1g, geranyl acetate 0.5g and linolenic acid 4.6g, stirs, and regulates the pH value of solution to 3.9.Make compositions two.
Embodiment three
Choosing has the pig 30 of following symptom: gradually to become thin or growth retardation, anorexia, spirit are depressed, be slow in action, mane is fluffy and disorderly, dyspnea etc.Be divided into treatment group and matched group, two groups of affected pig ages, clinical manifestation and state of an illness weights are unanimous on the whole.Each 15 examples for the treatment of group matched group, treatment group joins in 500ml drinking water by 5ml compositions one, and every pig is pressed and supplies 500ml/ day.Matched group isolated rearing, Routine Management.The mental status, the body temperature of pig, situation of searching for food is observed every day after process.Sick pig medication clinical symptom disappearance after 5 days, the normal person of body temperature, appetite, the mental status is judged to healing; Sick pig medication is appetite, mental status improvement after 5 days, and the normal person of body temperature is judged to improvement; Taking a turn for the better and curing all is judged to effectively; Sick pig medication after 10 days still lassitude, anorexia or death be judged to invalid.Result is as table one.
The effect of table one drinking technique compositions treatment virosis pig
Compositions one joins the therapeutic effect of drinking water to sick pig and reaches 86.7%, and the sick pig of matched group has 8 death, does not still get well after 10 days for 7.Compositions one has the therapeutic effect of highly significant.
Embodiment four
Choosing has the pig 20 of virus symptoms.Be divided into treatment group and matched group, two groups of affected pig ages, clinical manifestation and state of an illness weights are unanimous on the whole.Each 10 examples for the treatment of group matched group, treatment group adds the ratio mix homogeneously of 10g compositions two in 500g feedstuff, and every day feeds.Matched group isolated rearing, conventional medicine manages.The mental status, the body temperature of pig and situation of searching for food is observed every day after process.Sick pig medication after 5 days body temperature, appetite, the normal person of the mental status be judged to healing; Appetite, the mental status take a turn for the better, the normal person of body temperature is judged to improvement; Take a turn for the better and cure and be all judged to effectively.Sick pig medication after 10 days still lassitude, anorexia or death be judged to invalid.After sick pig treats 5 days by compositions two, clinical symptoms starts to disappear, and begin to show therapeutic effect, continue the feedstuff of feeding containing compositions two, after 15 days, 8 sick pigs recover normal substantially, and effective percentage reaches 80%.
Table two feedstuff method compositions two treats the effect of virosis pig
The therapeutic effect being added compositions two by feedstuff reaches 80%, and appetite recovers normal.The sick pig of conventional medicine matched group has 5 death, does not still get well after 10 days for 3.Compositions two has the therapeutic effect of highly significant, and what promote pig takes food growth.
Embodiment five
Get Healthy female mice and be divided into 3 groups, 10/group, average every only heavy 20g.Get well-grown mouse bearing liver cancer H22 cell and be adjusted to 2 × 10 with normal saline
6the cell suspension of individual/ml concentration, is inoculated in right side of mice armpit by 0.2ml/ volume subcutaneous.Negative control group synchronously gives N.S. with tested group.Test component is high dose composition two (100mg/Kg) and low dose group compound two (50mg/Kg) two subgroups.By the administration volume gastric infusion successive administration 10 days of 0.3ml/10g, administration terminates rear next day gets tumor and weighs and calculate tumour inhibiting rate.
The impact that table three compositions two grows rat liver cancer H22
Note: gastric infusion; The each group of average tumor of mice is heavily measurement data.
The compositions gastric infusion of various dose has good inhibition to animal hepatocarcinoma.Relative to chemical anti-tumor drugs, the feature of this compositions does not affect animal appetite, and weight ratio negative control group increase about 10% when animal subject administration completes, shows that product of the present invention has good using value.
Embodiment six
Select 2, the Eriocheir sinensis pool, 5 mu, each Eriocheir sinensis pool, be divided into compositions one to process on 2 Eriocheir sinensis pools and contrast two groups with Routine Management.Juvenile crab 6000 is thrown on each Eriocheir sinensis pool.Treatment Design is spray by the every mu of Eriocheir sinensis pool water surface compositions one that 50 liters of concentration are 2%, within interval 10-15 days, sprays once.When high temperature is sultry every day observed and recorded Eriocheir sinensis death condition.When fishing for, each Eriocheir sinensis pool Weighing respectively, calculates the rate of recapture.
The effect of table four compositions one on steamed crab
| Group | Monomer heavy (gram) | Amount of fishing (jin) | Rate of recapture % |
| Contrast | 125 | 195 | 65 |
| Compositions one | 160 | 307 | 80 |
Compositions one significantly effectively reduce high temperature sultry time the water hypoxia steamed crab that causes dead, and significantly promote steamed crab growth.
Claims (5)
1. activate the fatty acid of animal immune resistance and the compositions of derivant thereof, it is characterized in that, said composition is obtained by the compound method preparation comprised the steps:
1) fatty acid of one or more following formulas containing 0.01-99.9999%, their ester, their salt or derivant or their mixture is selected:
And/or
In formula, X is H, C
1-C
31alkyl or alkenyl, 2-hydroxyethyl, 2-hydroxypropyl;
Y is H, C
1-C
4alkyl or alkenyl, metal or nonmetalloid or group;
Z is H, OH, C
1-C
4alkyl or alkenyl, metal or nonmetalloid or group;
2) by step 1) described fatty acid, their ester, their salt or derivant or their mixture and following any one or Multiple components combination in any before being administered to target site or when being administered to target site, a kind of anion sulfate or sulfosalt surfactant, one or more edible essences, one or more polysaccharide high molecular polymers, one or more inorganic or organic compound strengthen animal immune resistance by having of being mixed of 0.1-95%, Tumor suppression grows, strengthen animal anti-stress ability, increase animal appetite, promote the compositions of growth of animal, the pH value of described compositions is 2.0-4.9.
2. compositions according to right 1, is characterized in that, described fatty acid including, but not limited to acetic acid, diacetic acid, butanoic acid, isopropylformic acid., valeric acid, isovaleric acid, caproic acid, isocaproic acid, certain herbaceous plants with big flowers acid, sad, Palmic acid, palmitic olefinic acid, stearic acid, linoleic acid, oleic acid, linolenic acid, lauric acid, myristic acid, n-nonanoic acid, arachidonic acid etc., and the salt that these fatty acids are made.
3. compositions according to right 1, is characterized in that, described polysaccharide high molecular polymer is including, but not limited to trehalose, starch, soluble starch, aminopolysaccharide, amino-oligosacchride, chitosan, glycosaminoglycans, chitosan, cellulose, hemicellulose, methylcellulose, sodium carboxymethyl cellulose, Cordyceps polysaccharide, astragalus polysaccharides, ginseng polysaccharide, Radix Notoginseng polysaccharide, dictyophora fungus polysaccharide, ganoderan, lentinan, zymosan etc.
4. compositions according to right 1, is characterized in that, described inorganic or organic compound including, but not limited to calcium chloride, sodium chloride, potassium chloride, zinc oxide, calcium oxide, calcium superphosphate, Sodium triphosphate, sodium bicarbonate, sodium polyphosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, sodium sulfate, zinc sulfate, copper sulfate, zinc acetate, potassium sulfate, calcium carbonate, amino acid calcium, amino-acid zinc, glucosan calcium, glucosan zinc, sodium carbonate, calcium bicarbonate, potassium bicarbonate, calcium sulfate, lime nitrate, calisanin, potassium carbonate etc.
5. compositions according to right 1, it is characterized in that, fatty acid, their ester, their salt or derivant, polysaccharide high molecular polymer and surfactant etc. are added to the water, under constantly stirring, add edible essence and inorganic or organic compound respectively, regulate the pH value of compositions to 2.0-4.9 with inorganic or organic acid or alkali.
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