CN104474573B - Biological mask and preparation method thereof - Google Patents
Biological mask and preparation method thereof Download PDFInfo
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- CN104474573B CN104474573B CN201410694548.0A CN201410694548A CN104474573B CN 104474573 B CN104474573 B CN 104474573B CN 201410694548 A CN201410694548 A CN 201410694548A CN 104474573 B CN104474573 B CN 104474573B
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- 238000002360 preparation method Methods 0.000 title claims description 27
- 239000000341 volatile oil Substances 0.000 claims abstract description 75
- 102000008186 Collagen Human genes 0.000 claims abstract description 62
- 108010035532 Collagen Proteins 0.000 claims abstract description 62
- 229920001436 collagen Polymers 0.000 claims abstract description 62
- 239000012528 membrane Substances 0.000 claims abstract description 41
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 230000000694 effects Effects 0.000 claims abstract description 20
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 20
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 19
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 19
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 19
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 19
- 229920001661 Chitosan Polymers 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 14
- 230000018044 dehydration Effects 0.000 claims abstract 2
- 238000006297 dehydration reaction Methods 0.000 claims abstract 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 42
- 229940033663 thimerosal Drugs 0.000 claims description 42
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- 238000001035 drying Methods 0.000 claims description 29
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- 239000007788 liquid Substances 0.000 claims description 23
- 230000008595 infiltration Effects 0.000 claims description 22
- 238000001764 infiltration Methods 0.000 claims description 22
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- 229940111202 pepsin Drugs 0.000 claims description 20
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 241000124008 Mammalia Species 0.000 claims description 10
- 238000005520 cutting process Methods 0.000 claims description 10
- 238000007598 dipping method Methods 0.000 claims description 10
- 239000004519 grease Substances 0.000 claims description 10
- 238000011068 loading method Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
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- 238000002156 mixing Methods 0.000 claims description 8
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 229910052700 potassium Inorganic materials 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- 235000010199 sorbic acid Nutrition 0.000 claims 3
- 229940075582 sorbic acid Drugs 0.000 claims 3
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- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 2
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- 238000011069 regeneration method Methods 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 61
- 239000000463 material Substances 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 16
- 206010052428 Wound Diseases 0.000 description 15
- 210000003491 skin Anatomy 0.000 description 11
- 230000008439 repair process Effects 0.000 description 10
- 239000002574 poison Substances 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 7
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- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
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- 239000003206 sterilizing agent Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
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- 235000015459 Lycium barbarum Nutrition 0.000 description 1
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- 229920004933 Terylene® Polymers 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
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- 239000003908 antipruritic agent Substances 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- 230000003834 intracellular effect Effects 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
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- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a biological mask. The biological mask is of a wet-type membrane and a dry-type membrane, wherein the wet-type membrane is prepared by infiltrating a chitosan non-woven membrane with a wet-type biological solution, and the wet-type biological solution is prepared from pure collagen concentrate, a plant essential oil disinfection solution, glycerol, chitosan powder and potassium sorbate; the dry-type membrane is prepared by infiltrating a chitosan non-woven membrane with a dry-type biological solution and carrying out dehydration, and the dry-type biological solution is prepared from pure collagen concentrate, the plant essential oil disinfection solution and the potassium sorbate; so that the biological mask does not have antigenicity, is good in flexibility, is capable of inducing regeneration of autologous skin, has the corresponding sterilization and disinfection effects and moisture retention function needed in the treatment process and is adapted to irregular wound surfaces.
Description
Technical field
The present invention relates to biological medicine and materials science field, more particularly, to a kind of biology applying film and preparation method.
Background technology
Skin damage is recurrent thing, if cannot fully treat, the lighter may leave spot after curing, sternly
Being likely to result in of weight causes bacterium infection to cause the serious diseases such as septicemia, or even threat to life.
The various applying films that the different material in market is made are treated to wound.If gelfoam is stopping of earliest use
Blood absorbent dressing, but its guiding cell growth performance is not so good as collagen.Other have promotion thin as polysaccharide, the class material such as hyaluronic acid
The function of intracellular growth, but increase with consumption, play the role of to suppress fibroblastic growth, polyurethane, terylene, nylon, silicon rubber
Glue etc. be bio-inert material, non-degradable it is impossible to carry out physiological metabolism, outer layer dressing can only be used as.The biological fall such as second lactide
Solution material, degradable, can metabolism, but if the little then insufficient strength of its molecular weight, molecular weight is insoluble in greatly water, during dissolving occur fall
Solution, the product after the mechanical strength of impact material, and its degraded makes to organize acidity to improve about, aseptic scorching
Disease.
The certain humidity of the growth needs of skin, clinical trauma care commonly uses the surface of a wound after sterile gauze covers incrustation, but
Gauze can not be degraded absorption, also absorb moisture it is impossible to induced skin regeneration and restoration and with surface of a wound bonding, give when removing gauze
Patient brings very big misery；Although existing market has the moist dressing of many, the risk producing is the richness in nutrition of liquid
Cause the growth of bacterium, due to the impact of environment and the sterilizing of dressing is insufficient or material does not have sterilizing function so that the surface of a wound is dirty
Contaminate and bacterial infection, affect treatment and even cause serious harm, and adopt the easy generation of chemosterilant certain to human body
Harm.
The dressing preparation process of various biomaterials is directed to the aseptic controlling problem of product, due to the eutrophy of material
Property and cycle of production generally require many days, even if making the breeding of also unavoidable bacterium in an aseptic environment, so that causing product
Product microbiological contamination or endotoxin exceeded although there being many sterilization methods, major part is all to adopt chemical method, although reached disappearing
The purpose of poison, but there is the potentially harm to human body in chemosterilant.
Content of the invention
It is an object of the invention to provide a kind of biology applying film and preparation method, have cell repair effect, no antigen,
Preferably human body skin surface of a wound suitability, and there are corresponding disinfection effect and the moisture-keeping functions required for therapeutic process,
It is suitable for various wound surface.
In order to achieve the above object, the technical scheme of present invention offer is：A kind of biology applying film, include wet type film and do
Dry type film, described wet type film is made up of wet type biological raw liquor infiltration shitosan non-woven membrane, described wet type biological solution
It is made up of collagen stoste, plants essential oil thimerosal, glycerine, chitosan powder, potassium sorbate；Described drying type film is by drying type
Be dehydrated and make after biological solution infiltration shitosan non-woven membrane, described drying type biological solution by wet type collagen stoste,
Plants essential oil thimerosal, potassium sorbate composition, the preparation of described wet type film comprises the following steps:
1）Plants essential oil is pressed 2 with ethanol:1-1:1 ratio mixes, and is subsequently adding weight than the chitosan powder for 1%-5%
Thick plants essential oil thimerosal is obtained after mixing；
2）The preparation of collagen：Take the tendon of mammal, remove grease, gone out with the sterilization of plants essential oil medicining liquid dipping
Bacterium, drains liquid after taking-up, make tendon possess certain plants essential oil thimerosal, then tendon being soaked in percent by volume is
In the acid solution of 1-5%, and add pepsin solution, make the pepsin in every milliliter of acid solution be 20-25 international activity
Unit, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen egg
White solution；
3）The glycerine that volume ratio is 10～25%, volume ratio is added to be less than 1% mountain in described collagen solution
Potassium sorbate and volume ratio are 0.1～10% plants essential oil thimerosal, mix and pour side's planar disk into after biological solution is obtained；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Seal after loading in lucifuge gas impermeable bag after shitosan non-woven membrane after infiltration is drained, protect after irradiation sterilization
Deposit.
A kind of biology applying film, including wet type film and drying type film, described wet type film is infiltrated by wet type biological raw liquor
Shitosan non-woven membrane is made, and described wet type biological solution is gathered by collagen stoste, plants essential oil thimerosal, glycerine, shell
Icing Sugar, potassium sorbate composition；Described drying type film is infiltrated to be dehydrated after shitosan non-woven membrane by drying type biological solution to be made, institute
State drying type biological solution to be made up of wet type collagen stoste, plants essential oil thimerosal, potassium sorbate, described drying type film
Preparation comprise the following steps：
1）Plants essential oil is pressed 2 with ethanol:1-1:1 ratio mixes, and is subsequently adding weight than the chitosan powder for 1%-5%
Thick plants essential oil thimerosal is obtained after mixing；
2）The preparation of collagen：Take the tendon of mammal, remove grease, gone out with the sterilization of plants essential oil medicining liquid dipping
Bacterium, drains liquid after taking-up, make tendon possess certain plants essential oil thimerosal, then tendon being soaked in percent by volume is
In the acid solution of 1-5%, and add pepsin solution, make the pepsin in every milliliter of acid solution be 20-25 international activity
Unit, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen egg
White solution；
3）In described collagen solution add volume ratio be less than 1% potassium sorbate and volume ratio be 0.1～
10% plants essential oil thimerosal, is obtained collagen stoste after mixing, collagen stoste is poured into side's planar disk；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Shitosan non-woven membrane after infiltration is drained and seals after being dehydrated again in loading lucifuge gas impermeable bag after being lyophilized again, spoke
Preserve according to after sterilizing.
The invention has the beneficial effects as follows：The present invention not only can play shitosan to impaired skin using shitosan non-woven membrane
The repair of skin, and a carrier can be provided for other liquid substances；Chitosan powder is added not only to play to skin
Repair, and thickening power can be played to solution, reach the certain sliminess of solution；Plant is added in manufacturing process
Thing essential oil disinfection agent, given full play to the disinfective action of plants essential oil so that the preparation process of product and use during permissible
Effectively prevent the growth of bacterium, it is to avoid product microbiological contamination and endotoxic severe overweight, relative chemical disinfectant, have preferably
Security and validity.Repair the initial stage in wound and repair initial stage offer nutriment and sterilization using wet type film for wound,
Drying type film is used to eliminate scar with more preferable wound of repairing in later stages of wound repair.
This product has needed for cell repair effect, no antigen, preferable human body skin surface of a wound suitability, therapeutic process
The corresponding disinfection effect wanted and moisture-keeping functions, are suitable for various wound surface.
Specific embodiment
Embodiment 1
A kind of biology applying film, including wet type film and drying type film, described wet type film is infiltrated by wet type biological solution
Shitosan non-woven membrane is made, and described wet type biological solution is by collagen stoste, plants essential oil thimerosal, glycerine, sorb
Sour potassium composition；Described drying type film is infiltrated to be dehydrated after shitosan non-woven membrane by drying type biological solution to be made, described drying type
Biological solution is made up of collagen stoste, plants essential oil thimerosal, potassium sorbate.
The preparation of described wet type film comprises the following steps:
1）Plants essential oil is pressed 1 with ethanol:1 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of described collagen：Take the tendon of mammal, remove grease, disappeared with plants essential oil medicining liquid dipping
Poison sterilizing, drains liquid, makes tendon possess certain plants essential oil thimerosal, then tendon is soaked in volume basis after taking-up
Ratio is in the acid solution for 1%, and adds pepsin solution, makes the pepsin in every milliliter of acid solution be 20 international activity lists
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）In described collagen solution add volume ratio be 10% glycerine, volume ratio be 0.5 potassium sorbate and
Volume ratio is 0.1% plants essential oil thimerosal, mixes and pours side's planar disk into after collagen stoste is obtained；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Seal after loading in lucifuge gas impermeable bag after shitosan non-woven membrane after infiltration is drained, protect after irradiation sterilization
Deposit.
The preparation of described drying type film comprises the following steps：
1）Plants essential oil is pressed 1 with ethanol:1 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of described collagen：Take the tendon of mammal, remove grease, disappeared with plants essential oil medicining liquid dipping
Poison sterilizing, drains liquid, makes tendon possess certain plants essential oil thimerosal, then tendon is soaked in volume basis after taking-up
Ratio is in the acid solution for 1%, and adds pepsin solution, makes the pepsin in every milliliter of acid solution be 20 international activity lists
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）The potassium sorbate of volume ratio 0.5% and volume ratio is added to be 0.1% plant essence in described collagen solution
Oily thimerosal, is obtained collagen stoste after mixing, collagen stoste is poured into side's planar disk；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Shitosan non-woven membrane after infiltration is drained and seals after being dehydrated again in loading lucifuge gas impermeable bag after being lyophilized again, spoke
Preserve according to after sterilizing.
Embodiment 2
A kind of biology applying film, including wet type film and drying type film, described wet type film is infiltrated by wet type biological solution
Shitosan non-woven membrane is made, and described wet type biological solution is by collagen stoste, plants essential oil thimerosal, glycerine, sorb
Sour potassium composition；Described drying type film is infiltrated to be dehydrated after shitosan non-woven membrane by drying type biological solution to be made, described drying type
Biological solution is made up of collagen stoste, plants essential oil thimerosal, potassium sorbate.
The preparation of described wet type film comprises the following steps:
1）Plants essential oil is pressed 2 with ethanol:1 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of described collagen：Take the tendon of mammal, remove grease, disappeared with plants essential oil medicining liquid dipping
Poison sterilizing, drains liquid, makes tendon possess certain plants essential oil thimerosal, then tendon is soaked in volume basis after taking-up
Ratio is in the acid solution for 5%, and adds pepsin solution, makes the pepsin in every milliliter of acid solution be 25 international activity lists
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）In described collagen solution add volume ratio be 25% glycerine, the potassium sorbate of volume ratio 0.1% and
Volume ratio is 10% plants essential oil thimerosal, mixes and pours side's planar disk into after collagen stoste is obtained；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Seal after loading in lucifuge gas impermeable bag after shitosan non-woven membrane after infiltration is drained, protect after irradiation sterilization
Deposit.
The preparation of described drying type film comprises the following steps：
1）Plants essential oil is pressed 2 with ethanol:1 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of described collagen：Take the tendon of mammal, remove grease, disappeared with plants essential oil medicining liquid dipping
Poison sterilizing, drains liquid, makes tendon possess certain plants essential oil thimerosal, then tendon is soaked in volume basis after taking-up
Ratio is in the acid solution for 5%, and adds pepsin solution, makes the pepsin in every milliliter of acid solution be 25 international activity lists
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）The potassium sorbate that volume ratio is 0.1% and volume ratio is added to be 10% plant essence in described collagen solution
Oily thimerosal, is obtained collagen stoste after mixing, collagen stoste is poured into side's planar disk；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Shitosan non-woven membrane after infiltration is drained and seals after being dehydrated again in loading lucifuge gas impermeable bag after being lyophilized again, spoke
Preserve according to after sterilizing.
Embodiment 3
A kind of biology applying film, including wet type film and drying type film, described wet type film is infiltrated by wet type biological solution
Shitosan non-woven membrane is made, and described wet type biological solution is by collagen stoste, plants essential oil thimerosal, glycerine, sorb
Sour potassium composition；Described drying type film is infiltrated to be dehydrated after shitosan non-woven membrane by drying type biological solution to be made, described drying type
Biological solution is made up of collagen stoste, plants essential oil thimerosal, potassium sorbate.
The preparation of described wet type film comprises the following steps:
1）Plants essential oil is pressed 3 with ethanol:2 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of described collagen：Take the tendon of mammal, remove grease, disappeared with plants essential oil medicining liquid dipping
Poison sterilizing, drains liquid, makes tendon possess certain plants essential oil thimerosal, then tendon is soaked in volume basis after taking-up
Ratio is in the acid solution for 3%, and adds pepsin solution, makes the pepsin in every milliliter of acid solution be 22 international activity lists
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）The potassium sorbate that the glycerine that volume ratio is 15%, volume ratio are 0.9% is added in described collagen solution
It is 0.6% plants essential oil thimerosal with volume ratio, mix and pour side's planar disk into after collagen stoste is obtained；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Seal after loading in lucifuge gas impermeable bag after shitosan non-woven membrane after infiltration is drained, after irradiation sterilization
Preserve.
The preparation of described drying type film comprises the following steps：
1）Plants essential oil is pressed 3 with ethanol:2 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of described collagen：Take the tendon of mammal, remove grease, disappeared with plants essential oil medicining liquid dipping
Poison sterilizing, drains liquid, makes tendon possess certain plants essential oil thimerosal, then tendon is soaked in volume basis after taking-up
Ratio is in the acid solution for 3%, and adds pepsin solution, makes the pepsin in every milliliter of acid solution be 22 international activity lists
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）The potassium sorbate of volume ratio 0.9% and volume ratio is added to be 0.6% plant essence in described collagen solution
Oily thimerosal, is obtained collagen stoste after mixing, collagen stoste is poured into side's planar disk；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Shitosan non-woven membrane after infiltration is drained and seals after being dehydrated again in loading lucifuge gas impermeable bag after being lyophilized again, spoke
Preserve according to after sterilizing.
One of material in present invention collagen stoste, can stimulate cell division, be conducive to cell to creep to wound
Position repair deficiency, and fibroblastic growth can be suppressed, the no formation of scar；Due to biological with human body cell interstitial identical
Composition, non-stimulated to human body, allergy and allergic reaction will not be produced；This material has biodegradability, and collagen can
It is degraded to polypeptide, can be absorbed by the body, the long period can be maintained in wound, be conducive to wound healing, save the nursing time, subtract
The light misery of patient and financial burden.Collagen degradable by amino acid thus being absorbed by human body.
The chitosan powder of two of the material in the present invention, this material has good activating cell effect, promotes newly old generation
Thank, repair the effect of old and feeble mutant；Non-stimulated to human body, allergy and allergic reaction will not be produced；This material has life
Thing degradation property, can be absorbed by the body, and can maintain the long period in wound, be conducive to wound healing；In addition in this product
Also have certain thickening power concurrently.
Three plants essential oil thimerosals of the material in the present invention, are made up of plants essential oil and a small amount of ethanol, plants essential oil
It is Chinese conventional Chinese medicine, the therapeutic action of tool skin, and have functions that antisepsis and sterilization and anti-inflammatory, using plants essential oil as sterilization
Agent can avoid the harm that human body may be produced due to other disinfectants, and has the suitable smell of human body and antalgesic-antipruritic,
Increase the comfort level of the process for the treatment of.The solution being formed after plants essential oil and ethanol mixing can make plants essential oil thimerosal mix
In biological solution, to prevent the microbiological contamination of biological solution.
The glycerine of four of the material in the present invention, in addition to having moisturizing, humectation function, also has high activity, anti-oxidant, rush
The special efficacies such as alcoholization.
The anti-corrosion function mainly to the various raw materials that product adopts for the potassium sorbate of the five of material in the present invention.
The shitosan non-woven membrane of six of the material in the present invention, this material has good activating cell effect, promotes
Metabolism, repairs the effect of old and feeble mutant, is not only to play shell using the maximum benefit of shitosan non-woven membrane
The repair to damaged skin for the glycan, and a carrier can be provided for solution mass.
The to sum up description to various material functions, its design advantage shows as, and cleverly make use of various materials from difference
Angle is treated to impaired skin wound, and make use of the physical aspect of various materials mutually to rely on, and is sticked with facilitating
Damaged skin surface is protected and is repaired, and promotes skin to increase, so that the surface of a wound is fully recovered.
The present invention can have plurality of specifications size as needed, suitably partes corporis humani can divide the injury in treating of epidermis；Also may be used
Nursing including skin surface.
The preparation of the present invention should be using aseptically carrying out, because manufacturing process takes pure method using material, can
The content of plants essential oil disinfectant can be affected, the resistance of material can be kept by the content being continuously replenished plants essential oil disinfectant
Bacterium, bacteriostasis.
Plants essential oil of the present invention includes Pogostemon cablin essential, tea tree ethereal oil, clove oil, eucalyptus quintessence oil, smokes clothing
Careless essential oil, Peppermint essential oil.
Material of the present invention is commercially available, for ensureing product quality, preferably as far as possible using the specification that purity is high.
Manufacture craft is collagen extraction process and common aseptic applying film manufacturing process.
Claims (2)
1. a kind of biology applying film it is characterised in that：Including wet type film, described wet type film infiltrates shell by wet type biological solution
Glycan non-woven membrane is made, and described wet type biological solution is by collagen stoste, plants essential oil thimerosal, glycerine, sorbic acid
Potassium forms, and the preparation of described wet type film comprises the following steps:
1）Plants essential oil is pressed 2 with ethanol:1-1:1 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of collagen：Take the tendon of mammal, remove grease, with plants essential oil medicining liquid dipping sterilization,
Drain liquid after taking-up, make tendon possess certain plants essential oil thimerosal, then tendon being soaked in percent by volume is 1-
In 5% acid solution, and add pepsin solution, make the pepsin in every milliliter of acid solution be 20-25 international activity list
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）The glycerine that volume ratio is 10～25%, volume ratio is added to be less than 1% sorbic acid in described collagen solution
Potassium and volume ratio are 0.1～10% plants essential oil thimerosal, mix and pour side's planar disk into after biological solution is obtained；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Seal after loading in lucifuge gas impermeable bag after shitosan non-woven membrane after infiltration is drained, preserve after irradiation sterilization.
2. a kind of biology applying film it is characterised in that：Including drying type film, described drying type film infiltrates shell by drying type biological solution
After glycan non-woven membrane, dehydration is made, and described drying type biological solution is by collagen stoste, plants essential oil thimerosal, sorbic acid
Potassium forms, and the preparation of described drying type film comprises the following steps：
1）Plants essential oil is pressed 2 with ethanol:1-1:1 ratio mixes, and is subsequently adding weight and mixes than the chitosan powder for 1%-5%
After obtain thick plants essential oil thimerosal；
2）The preparation of collagen：Take the tendon of mammal, remove grease, with plants essential oil medicining liquid dipping sterilization,
Drain liquid after taking-up, make tendon possess certain plants essential oil thimerosal, then tendon being soaked in percent by volume is 1-
In 5% acid solution, and add pepsin solution, make the pepsin in every milliliter of acid solution be 20-25 international activity list
Position, stirs and evenly mixs, and being dipped to solution viscosity at room temperature is 500-1000cp (centipoise), filters and purifies to obtain high concentration collagen
Solution；
3）Adding volume ratio to be less than 1% potassium sorbate and volume ratio in described collagen solution is 0.1～10% plant
Thing essential oil disinfection liquid, is obtained collagen stoste after mixing, collagen stoste is poured into side's planar disk；
4）By shitosan non-woven membrane by applying in disk infiltration after required size cutting；
5）Shitosan non-woven membrane after infiltration is drained and seals after being dehydrated again in loading lucifuge gas impermeable bag after being lyophilized again, irradiation goes out
Preserve after bacterium.
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| CN201410694548.0A CN104474573B (en) | 2014-11-27 | 2014-11-27 | Biological mask and preparation method thereof |
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| CN201410694548.0A CN104474573B (en) | 2014-11-27 | 2014-11-27 | Biological mask and preparation method thereof |
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| CN106511977A (en) * | 2016-11-04 | 2017-03-22 | 广州赛莱拉干细胞科技股份有限公司 | Collagen dressing |
| CN107184412A (en) * | 2017-04-14 | 2017-09-22 | 绍兴金石生物工程有限公司 | The preparation method that liquid is repaired in a kind of moisturizing |
| CN108404194A (en) * | 2018-04-20 | 2018-08-17 | 朱清 | A kind of preparation method of quick-acting haemostatic powder gauze |
| CN112263488A (en) * | 2020-11-05 | 2021-01-26 | 防城港盛农磷化有限公司 | Preparation method of collagen mask |
| CN113730641A (en) * | 2021-09-28 | 2021-12-03 | 珠海金标生物科技有限公司 | Slow-release antibacterial dressing and preparation method thereof |
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| CN101791425B (en) * | 2010-03-30 | 2013-04-10 | 赵雪林 | Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof |
| CN103749563A (en) * | 2011-12-30 | 2014-04-30 | 青岛艾华隆生物科技有限公司 | Plant essential oil composition disinfectant |
| CN102643554B (en) * | 2012-05-08 | 2013-12-04 | 福州大学 | Edible fishskin collagen antibiosis membrane and preparing method thereof |
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