CN104473822A - Mouthwash tablet containing plant extract and preparation method thereof - Google Patents
Mouthwash tablet containing plant extract and preparation method thereof Download PDFInfo
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- CN104473822A CN104473822A CN201410716890.6A CN201410716890A CN104473822A CN 104473822 A CN104473822 A CN 104473822A CN 201410716890 A CN201410716890 A CN 201410716890A CN 104473822 A CN104473822 A CN 104473822A
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- 239000000419 plant extract Substances 0.000 title claims abstract description 52
- 239000002324 mouth wash Substances 0.000 title claims description 53
- 229940051866 mouthwash Drugs 0.000 title claims description 53
- 238000002360 preparation method Methods 0.000 title claims description 18
- 238000002156 mixing Methods 0.000 claims abstract description 68
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 43
- 238000003756 stirring Methods 0.000 claims abstract description 36
- 238000005187 foaming Methods 0.000 claims abstract description 28
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 23
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 22
- 239000003765 sweetening agent Substances 0.000 claims abstract description 22
- 239000002562 thickening agent Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 8
- 239000003599 detergent Substances 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims description 41
- 239000000796 flavoring agent Substances 0.000 claims description 28
- 235000019634 flavors Nutrition 0.000 claims description 28
- 241000218378 Magnolia Species 0.000 claims description 18
- 229940041616 menthol Drugs 0.000 claims description 17
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 16
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 16
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 15
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 15
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 15
- 239000003242 anti bacterial agent Substances 0.000 claims description 15
- 239000011425 bamboo Substances 0.000 claims description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 14
- 229920000858 Cyclodextrin Polymers 0.000 claims description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 235000013305 food Nutrition 0.000 claims description 14
- 239000003292 glue Substances 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 14
- 229920001661 Chitosan Polymers 0.000 claims description 11
- 239000004373 Pullulan Substances 0.000 claims description 11
- 229920001218 Pullulan Polymers 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 235000019423 pullulan Nutrition 0.000 claims description 11
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
- -1 sodium lauryl triethanolamine sulfate Chemical compound 0.000 claims description 10
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 10
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 9
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 9
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- 239000000843 powder Substances 0.000 claims description 9
- JWZSXZWCWMCYPE-RSAXXLAASA-M sodium;(4s)-4-amino-5-dodecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O JWZSXZWCWMCYPE-RSAXXLAASA-M 0.000 claims description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- 244000247812 Amorphophallus rivieri Species 0.000 claims description 8
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- 229920002907 Guar gum Polymers 0.000 claims description 8
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- 239000004368 Modified starch Substances 0.000 claims description 8
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- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 8
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 8
- 239000000665 guar gum Substances 0.000 claims description 8
- 235000010417 guar gum Nutrition 0.000 claims description 8
- 229960002154 guar gum Drugs 0.000 claims description 8
- 239000000252 konjac Substances 0.000 claims description 8
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 8
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- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 8
- 235000019408 sucralose Nutrition 0.000 claims description 8
- 239000000811 xylitol Substances 0.000 claims description 8
- 235000010447 xylitol Nutrition 0.000 claims description 8
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 8
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 7
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 7
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- 239000005913 Maltodextrin Substances 0.000 claims description 7
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- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 7
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 7
- 229960004853 betadex Drugs 0.000 claims description 7
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 7
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 7
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 7
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 7
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 239000000686 essence Substances 0.000 claims description 7
- 229940075529 glyceryl stearate Drugs 0.000 claims description 7
- 229940035034 maltodextrin Drugs 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 229960000502 poloxamer Drugs 0.000 claims description 7
- 229920001983 poloxamer Polymers 0.000 claims description 7
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 7
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000377 silicon dioxide Substances 0.000 claims description 7
- 235000012239 silicon dioxide Nutrition 0.000 claims description 7
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 4
- 108010077895 Sarcosine Proteins 0.000 claims description 4
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 claims description 4
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 claims description 4
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Natural products C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 3
- 229940054190 hydroxypropyl chitosan Drugs 0.000 claims description 3
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims description 3
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 3
- 229960000282 metronidazole Drugs 0.000 claims description 3
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 2
- 244000082204 Phyllostachys viridis Species 0.000 claims 2
- 235000013312 flour Nutrition 0.000 claims 2
- MKJBXLAMJXIIAF-RSAXXLAASA-N (2s)-2-(dodecylamino)pentanedioic acid;sodium Chemical compound [Na].CCCCCCCCCCCCN[C@H](C(O)=O)CCC(O)=O MKJBXLAMJXIIAF-RSAXXLAASA-N 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 14
- 210000000214 mouth Anatomy 0.000 abstract description 9
- 241000894006 Bacteria Species 0.000 abstract description 6
- 206010006326 Breath odour Diseases 0.000 abstract description 5
- 230000002147 killing effect Effects 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 4
- 238000002791 soaking Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 208000032139 Halitosis Diseases 0.000 abstract 1
- 229920000715 Mucilage Polymers 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 32
- 241001330002 Bambuseae Species 0.000 description 13
- 244000132059 Carica parviflora Species 0.000 description 9
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- 229960000988 nystatin Drugs 0.000 description 6
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 6
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 5
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Description
技术领域 technical field
本发明涉及口腔护理用品领域,具体涉及一种含有植物提取物漱口片及其制作方法。 The invention relates to the field of oral care products, in particular to a mouthwash tablet containing plant extracts and a preparation method thereof.
背景技术 Background technique
一口美丽亮白的牙齿能够为个人形象增色不少,然而牙齿疾病也困扰着许多人,特别是龋齿严重影响了人的形象、社交以及身体健康。 A beautiful and bright white teeth can add a lot to personal image, but dental disease also plagues many people, especially dental caries seriously affects people's image, social interaction and physical health.
市面上现在有多种帮助用户进行口腔保健的产品,常见的有牙膏、口香糖、漱口水、口气清新剂等产品,能够通过清洁牙齿,消除口气、杀灭细菌等方式,对口腔保健起到积极的治疗与保健作用。 There are many products on the market to help users maintain oral health. Common products include toothpaste, chewing gum, mouthwash, and breath fresheners, which can play a positive role in oral health by cleaning teeth, eliminating bad breath, and killing bacteria. therapeutic and health effects.
然而以上的产品也存在有一定缺陷,牙膏是一种运用最广泛,清洁效率最好的牙齿清洁产品,但其存在体积过大,携带不便的问题;口香糖能清洁牙齿消除口气清洁牙齿,但其对牙齿细菌的无杀灭效果;口气清新剂有杀菌型和非杀菌型,能清洁口气,但无法对牙齿进行有效的清洁;漱口水携带方便,能够清洁牙齿、消除口气、杀灭细菌,运用广泛,但液态的漱口水一旦泄漏可能浸湿其他重要物品,造成不可弥补的损失。 However, the above products also have certain defects. Toothpaste is the most widely used tooth cleaning product with the best cleaning efficiency, but it has the problems of large size and inconvenient portability; chewing gum can clean teeth and eliminate bad breath. It has no killing effect on tooth bacteria; breath fresheners have bactericidal and non-bacterial types, which can clean breath, but cannot effectively clean teeth; mouthwash is easy to carry, can clean teeth, eliminate breath, and kill bacteria. Widespread, but a leak of liquid mouthwash may soak other important items, causing irreparable damage.
有鉴于此,市面上有厂家开始研发并制造出漱口片,其清洁牙齿,消除口气、杀灭细具备的功能,且方便携带,固体状避免了泄漏浸湿其他物品的可能。 In view of this, some manufacturers on the market have begun to develop and manufacture mouthwash tablets, which have the functions of cleaning teeth, eliminating bad breath, and killing bacteria, and are easy to carry. The solid form avoids the possibility of leaking and soaking other items.
CN200710032657提供了一种漱口片及其制备方法,呈固体片状,是入口分散型口腔护理产品,其含有成膜剂、清新剂、乳化剂,起泡清洁剂和摩擦剂,该固体漱口片能同时提供抑菌、清洁口腔、去除口气,预防龋齿等作用,且携带方便,使用容易。但该入口型分散性的漱口片的使用方式是通过含入漱口片再含清水漱口,该漱口片含有较多的起泡清洁剂、成膜剂,它们会迅速吸收口腔中的水分,会短时间是口腔变得干燥,甚至破坏口腔的黏膜,另外过多的增塑剂也会致使人的肝肾、生殖功能造成损伤,具有致突变与致癌性。 CN200710032657 provides a mouthwash tablet and a preparation method thereof, which is in the form of a solid sheet and is an entrance-dispersed oral care product, which contains a film-forming agent, a refreshing agent, an emulsifier, a foaming cleanser and an abrasive, and the solid mouthwash The tablet can simultaneously provide antibacterial, oral cavity cleaning, breath removal, dental caries prevention and other functions, and is easy to carry and use. But the use mode of this entrance-type dispersible mouthwash tablet is to contain clear water mouthwash again by being included in the mouthwash tablet, and this mouthwash tablet contains more foaming cleansers, film-forming agents, and they can quickly absorb the oral cavity Moisture will dry the mouth in a short time, and even damage the oral mucosa. In addition, too much plasticizer will also cause damage to human liver, kidney, and reproductive functions, and is mutagenic and carcinogenic.
CN201010220670提供了一种含有制霉素漱口制剂,其可以制成漱口片、泡腾片、分散片、颗粒剂、口含片等形式的制剂,含有的制霉素成分用于预防与治疗口腔真菌感染。该制剂采用的制霉素是一种广谱抗真菌药,其制品功能是主要作为医药制品,针对口腔真菌感染而制作,日常长期使用会使口腔内菌群失衡,不可作为日常口腔清洁护理使用。 CN201010220670 provides a mouthwash preparation containing nystatin, which can be made into preparations in the form of mouthwash tablets, effervescent tablets, dispersible tablets, granules, buccal tablets, etc., and the nystatin ingredients contained are used for prevention and treatment Oral fungal infection. The nystatin used in this preparation is a broad-spectrum antifungal drug. Its product function is mainly used as a pharmaceutical product, which is made for oral fungal infection. Daily long-term use will cause the imbalance of oral flora, so it cannot be used as daily oral cleaning care .
CN200810103364提供一种具有协同作用的制霉素薄荷醇组合物,其制作剂型的最优选方式为漱口片,含有的制霉素成分用于预防与治疗口腔真菌感染,与薄荷醇的按比例配置能够获得良好的协同治疗效果。但同样的,该制剂的主要功能是作为医药制品,广谱抗真菌药制霉素使得该品不适用于日常口腔清洁护理。 CN200810103364 provides a synergistic nystatin-menthol composition, the most preferred way of making dosage form is mouthwash tablet, the nystatin component contained is used to prevent and treat oral fungal infection, and the proportion of nystatin and menthol is configured A good synergistic therapeutic effect can be obtained. But equally, the main function of this preparation is as a pharmaceutical product, and the broad-spectrum antifungal drug nystatin makes this product unsuitable for daily oral cleaning care.
CN200580048793提供了一种使用木兰提取物减少口腔组织炎症的方法,利用木兰的天然抗炎活性成分减少一种或多种验证介导物而减少口腔组织中的炎症。木兰提取物的天然抗炎活性成分安全、有效、且无刺激性。该组合物可以生产牙膏、凝胶、粉末、锭剂等形式,但未提供具体制成可携带清洁口腔产品的方法。 CN200580048793 provides a method of using magnolia extract to reduce oral tissue inflammation, using magnolia's natural anti-inflammatory active ingredients to reduce one or more verified mediators to reduce inflammation in oral tissue. The natural anti-inflammatory active ingredient of magnolia extract is safe, effective and non-irritating. The composition can be produced in the form of toothpaste, gel, powder, lozenge, etc., but does not provide a specific method for making a portable oral cleaning product.
CN95104632.2提供了一种草珊瑚漱口水,通过预制草珊瑚提取液,再将天然薄荷油、吐温-80、95%食用乙醇、药用甘油含重量比例混合后,加入草珊瑚提取液、附加剂以及蒸馏水搅拌制得漱口水。该产品同样是液态状态且不易携带。 CN95104632.2 provides a kind of coral coral mouthwash, by prefabricating the coral coral extract, then mixing natural peppermint oil, Tween-80, 95% edible ethanol, and medicinal glycerin in the weight ratio, adding the coral coral extract, Additives and distilled water were stirred to prepare mouthwash. This product is also in liquid state and not easy to carry.
发明内容 Contents of the invention
本发明提供一种含有植物提取物漱口片及其制作方法,通过泡入水中后迅速溶解,形成漱口液,然后直接用该漱口液进行漱口以获得口腔的清洁护理,达到清洁牙齿,消除口气、杀灭细菌的效果,同时该漱口片能够作为日常口腔清洁护理用品使用。 The invention provides a mouthwash tablet containing plant extracts and a preparation method thereof. After soaking in water, it dissolves quickly to form a mouthwash, and then directly uses the mouthwash to rinse the mouth to obtain oral cavity cleaning and care, so as to clean teeth , the effect of eliminating bad breath and killing bacteria, and at the same time, the mouthwash tablet can be used as a daily oral cleaning care product.
为实现上述目的,本发明采用以下技术手段,具体步骤如下: To achieve the above object, the present invention adopts the following technical means, and the concrete steps are as follows:
含有植物提取物漱口片,其形态为片状固体,是通过溶解于水中化为漱口液进行使用。按成品干重各组分的重量百分比如下: Mouthwash tablets containing plant extracts are flake-like solids that are dissolved in water and turned into mouthwash for use. The weight percent of each component by finished product dry weight is as follows:
天然植物提取物 8-15% Natural plant extracts 8-15%
成膜剂 20-40% Film former 20-40%
摩擦剂 10-25% Friction agent 10-25%
食用香精 4-16% Food flavor 4-16%
乳化剂 5-10% Emulsifier 5-10%
起泡清洁剂 2-10% Foaming Cleanser 2-10%
增稠剂 15-25% Thickener 15-25%
抑菌剂 1~3% Antibacterial agent 1~3%
甜味剂 1~3% Sweetener 1~3%
所述的天然植物提取物是粉末状的草珊瑚提取物以及粉末状的木兰提取物按5~10:3~5的比例混合而成; Described natural plant extract is formed by mixing powdery Coralia praecox extract and powdery Magnolia extract in a ratio of 5-10:3-5;
优选的,草珊瑚提取物中纯品含量为25~50%,木兰提取物中纯品含量为25~50%。 Preferably, the pure product content in the grass coral extract is 25-50%, and the pure product content in the magnolia extract is 25-50%.
所述的成膜剂可以是羧甲基纤维素、羟乙基纤维素、羟丙基纤维素中的一种或多种和壳聚糖、海藻酸钠、变性淀粉、普鲁兰、麦芽糊精、瓜尔胶、魔芋精粉中的一种或多种混合制成。 Described film-forming agent can be one or more in carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose and chitosan, sodium alginate, modified starch, pullulan, malt paste It is made by mixing one or more of fine powder, guar gum and konjac powder.
优选的,成膜剂选用羧甲基纤维素、羟乙基纤维素、羟丙基纤维素以重量比为1:2:3和壳聚糖、海藻酸钠、变性淀粉、普鲁兰、麦芽糊精、瓜尔胶、魔芋精粉中的一种或多种混合制成。 Preferably, the film-forming agent is selected carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose in a weight ratio of 1:2:3 and chitosan, sodium alginate, modified starch, pullulan, malt It is made by mixing one or more of dextrin, guar gum, and konjac powder.
更优选的,膜剂选用羧甲基纤维素、羟乙基纤维素、羟丙基纤维素以重量比为1:2:3和壳聚糖、普鲁兰、麦芽糊精以重量比为1:1:1的比例混合制得。 More preferably, film agent selects carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose with a weight ratio of 1:2:3 and chitosan, pullulan, maltodextrin with a weight ratio of 1 : Prepared by mixing in a ratio of 1:1.
所述的摩擦剂通过二氧化硅、碳酸氢钙和碳酸钙以重量比为1:5:4比例混合制得。 The friction agent is prepared by mixing silicon dioxide, calcium bicarbonate and calcium carbonate at a weight ratio of 1:5:4.
所述的食用香精为竹香精以及能薄荷醇,通过竹香精和薄荷醇以重量比为2:1的比例混合制得。 The food flavor is bamboo flavor and menthol, which is prepared by mixing bamboo flavor and menthol at a weight ratio of 2:1.
所述的乳化剂为交联羧甲甲淀粉钠、泊洛沙姆、硬脂酸甘油脂以重量比为1:2:2的比例混合制得。 The emulsifier is prepared by mixing croscarmellose sodium, poloxamer, and glyceryl stearate in a weight ratio of 1:2:2.
所述的起泡清洁剂可选用月桂基三乙醇胺硫酸钠、月桂酰肌氨酸钠、十二烷基硫酸钠、月桂基谷氨酸钠中的一种或多种混合制得。 The foaming cleanser can be prepared by mixing one or more of sodium lauryl triethanolamine sulfate, sodium lauryl sarcosinate, sodium lauryl sulfate and sodium lauryl glutamate.
优选的,所述的起泡清洁剂选择月桂基三乙醇胺硫酸钠、十二烷基硫酸钠、月桂基谷氨酸钠以重量比为1:3:2的比例混合制得。 Preferably, the foaming cleanser is prepared by mixing sodium lauryl triethanolamine sulfate, sodium lauryl sulfate, and sodium lauryl glutamate in a weight ratio of 1:3:2.
所述的增稠剂是环状糊精和倍他环糊精以重量比为1:3的形式混合制得。 The thickener is prepared by mixing cyclodextrin and beta-cyclodextrin in a weight ratio of 1:3.
所述的抑菌剂为醋酸洗必泰、苯扎溴铵、2,4,4’-三氯2’-羟基二苯醚、甲硝锉、氯化十六烷基吡啶中的一种或多种混合制成。 The bacteriostatic agent is one of chlorhexidine acetate, benzalkonium bromide, 2,4,4'-trichloro 2'-hydroxyl diphenyl ether, metronidazole, cetylpyridinium chloride or Various blends are made.
优选的,所述的抑菌剂的可选择醋酸洗必泰、2,4,4’-三氯2’-羟基二苯醚和氯化十六烷基吡啶以1:1:1的比例混合而成。 Preferably, the optional chlorhexidine acetate, 2,4,4'-trichloro 2'-hydroxydiphenyl ether and cetylpyridinium chloride of the bacteriostatic agent are mixed in a ratio of 1:1:1 made.
所述的甜味剂通过木糖醇和三氯蔗糖以3:1的比例混合制得。 The sweetener is prepared by mixing xylitol and sucralose in a ratio of 3:1.
本发明还提供了一种含有植物提取物漱口片及其制作方法,通过以下步骤制成: The present invention also provides a mouthwash tablet containing plant extracts and a preparation method thereof, which are made through the following steps:
步骤1:将成膜剂加入到去离子水中,两者的重量比为1:3,边加热边搅拌,并边加入上述摩擦剂、乳化剂、起泡清洁剂、增稠剂, 搅拌速度设置为500r/min,当以上混合物升温65℃时加入食用香精、抑菌剂、甜味剂,继续保持此加热温度,调节搅拌速度为800r/min搅拌0.5h,再降温至45℃后加入天然植物提取物,搅拌0.5小时后形成胶浆; Step 1: Add the film-forming agent to deionized water, the weight ratio of the two is 1:3, stir while heating, and add the above friction agent, emulsifier, foaming detergent, thickener, and set the stirring speed 500r/min, when the temperature of the above mixture rises to 65°C, add edible essence, antibacterial agent, and sweetener, continue to maintain the heating temperature, adjust the stirring speed to 800r/min and stir for 0.5h, then cool down to 45°C and add natural plants Extract, form glue after stirring for 0.5 hours;
步骤2:将步骤1中所得的胶浆制成薄膜,并保证其由一定的厚度; Step 2: Make the glue obtained in step 1 into a film, and ensure that it has a certain thickness;
步骤3:将步骤2中所得的薄膜蒸干成膜,保证其水分含量在15%~18%,冷却后切片获得所述的含有植物提取物漱口片。 Step 3: Evaporate the film obtained in step 2 to form a film, ensure that its water content is 15% to 18%, slice it after cooling, and obtain the mouthwash tablet containing plant extracts.
优选的,将冷却后的薄膜切割为50mm×40mm×0.2mm的切片。 Preferably, the cooled film is cut into slices of 50mm×40mm×0.2mm.
本发明的有益之处在于,将天然植物提取物添加到漱口片中,利用草珊瑚提取物具备的清热解毒、消肿止痛、抗菌消炎的功能以及木兰提取物中具备消炎镇痛、抑菌、洁白的功效,相对其他人工合成的抑菌剂、镇痛成分、美白剂,具有较高的安全性,同时采用天然植物提取物能够减少对口腔的刺激。 The benefit of the present invention is that the natural plant extracts are added to mouthwash tablets, and the functions of heat-clearing and detoxification, swelling and pain relief, antibacterial and anti-inflammation possessed by the grass coral extract and the functions of anti-inflammatory, analgesic and antibacterial properties in the magnolia extract are beneficial. , Whitening effect, compared with other synthetic antibacterial agents, analgesic ingredients, whitening agents, it has higher safety, and the use of natural plant extracts can reduce the irritation to the oral cavity.
同时选择不掩盖天然植物提取物气味的竹香精以及能够提供提供清爽口感的薄荷醇,并加入提高本产品的适口性的木糖醇和三氯蔗糖,使产品提供自然、清爽的口感。 At the same time, choose bamboo essence that does not cover the smell of natural plant extracts and menthol that can provide a refreshing taste, and add xylitol and sucralose to improve the palatability of this product, so that the product provides a natural and refreshing taste.
加入所述的起泡清洁剂能够在漱口是能形成丰富的泡沫,可乳化和去除口腔中的污渍,加强本产品的清洁能力。 Adding the foaming cleanser can form rich foam when gargling, can emulsify and remove stains in the oral cavity, and strengthen the cleaning ability of the product.
具体实施方式 Detailed ways
本发明公开了一种含有植物提取物漱口片及其制作方法,本领域的技术人员可以借鉴本文内容,适当改造工艺参数实现本品的制作。特别需要指出的是,所有类似的替换和改动对本领域技术人员来说是显而易见的,他们都被视为包括在本发明。本发明所述的含有植物提取物漱口片及其制作方法已经经过了较佳的实施例进行了描述,相关人员明显能在不脱离本发明内容、精神和范围内对本文所述的方法和应用进行改动或适当变更与组合,来实现和应用本发明技术。 The invention discloses a mouthwash tablet containing plant extracts and a preparation method thereof. Those skilled in the art can refer to the contents of this article and appropriately modify process parameters to realize the preparation of the product. In particular, it should be pointed out that all similar replacements and modifications that are obvious to those skilled in the art are deemed to be included in the present invention. The plant extract-containing mouthwash tablet of the present invention and its preparation method have been described through preferred embodiments, and relevant personnel can clearly understand the methods and methods described herein without departing from the content, spirit and scope of the present invention. The technology of the present invention can be realized and applied by making changes or appropriate changes and combinations.
如无特别说明,在具体实施方式中涉及的试验材料均可从市场自由购得。 Unless otherwise specified, the test materials involved in the specific embodiments can be purchased freely from the market.
实施例1 Example 1
含有植物提取物漱口片,按成品干重各组分的重量百分比如下: Mouthwash tablets containing plant extracts, the weight percentage of each component according to the dry weight of the finished product is as follows:
天然植物提取物 12% Natural plant extracts 12%
成膜剂 40% Film former 40%
摩擦剂 10% Friction agent 10%
食用香精 8% Food flavor 8%
乳化剂 5% Emulsifier 5%
起泡清洁剂 2% Foaming Cleanser 2%
增稠剂 20% Thickener 20%
抑菌剂 1% Antibacterial agent 1%
甜味剂 2% Sweetener 2%
所述的天然植物提取物是粉末状的草珊瑚提取物以及粉末状的木兰提取物按5:3的比例混合而成,其中草珊瑚提取物的纯品含量为38%,木兰提取物的纯品含量为38%。 Described natural plant extract is that powdery Coralia praecox extract and powdery Magnolia extract are mixed in the ratio of 5:3, and wherein the pure product content of Coralia pratense extract is 38%, the pure product of Magnolia extract The product content is 38%.
所述的成膜剂为羧甲基纤维素中和壳聚糖、海藻酸钠、变性淀粉、普鲁兰、麦芽糊精、瓜尔胶、魔芋精粉中的一种或多种混合制成。 The film-forming agent is prepared by mixing carboxymethyl cellulose with one or more of chitosan, sodium alginate, modified starch, pullulan, maltodextrin, guar gum, and konjac powder .
所述的摩擦剂通过二氧化硅、碳酸氢钙和碳酸钙以重量比为1:5:4比例混合制得。 The friction agent is prepared by mixing silicon dioxide, calcium bicarbonate and calcium carbonate at a weight ratio of 1:5:4.
所述的食用香精为竹香精以及能薄荷醇,通过竹香精和薄荷醇以重量比为2:1的比例混合制得。 The food flavor is bamboo flavor and menthol, which is prepared by mixing bamboo flavor and menthol at a weight ratio of 2:1.
所述的乳化剂为交联羧甲甲淀粉钠、泊洛沙姆、硬脂酸甘油脂以重量比为1:2:2的比例混合制得。 The emulsifier is prepared by mixing croscarmellose sodium, poloxamer, and glyceryl stearate in a weight ratio of 1:2:2.
所述的起泡清洁剂可选用月桂基三乙醇胺硫酸钠、月桂酰肌氨酸钠、十二烷基硫酸钠、月桂基谷氨酸钠中的一种或多种混合制得。 The foaming cleanser can be prepared by mixing one or more of sodium lauryl triethanolamine sulfate, sodium lauryl sarcosinate, sodium lauryl sulfate and sodium lauryl glutamate.
所述的增稠剂是环状糊精和倍他环糊精以重量比为1:3的形式混合制得。 The thickener is prepared by mixing cyclodextrin and beta-cyclodextrin in a weight ratio of 1:3.
所述的抑菌剂为2,4,4’-三氯2’-羟基二苯醚、甲硝锉、氯化十六烷基吡啶混合制成。 The bacteriostatic agent is prepared by mixing 2,4,4'-trichloro 2'-hydroxydiphenyl ether, metronidazole and cetylpyridinium chloride.
所述的甜味剂通过木糖醇和三氯蔗糖以3:1的比例混合制得。 The sweetener is prepared by mixing xylitol and sucralose in a ratio of 3:1.
本发明还提供了一种含有植物提取物漱口片及其制作方法,通过以下步骤制成: The present invention also provides a mouthwash tablet containing plant extracts and a preparation method thereof, which are made through the following steps:
步骤1:将成膜剂加入到去离子水中,两者的重量比为1:3,边加热边搅拌,并边加入上述摩擦剂、乳化剂、起泡清洁剂、增稠剂, 搅拌速度设置为500r/min,当以上混合物升温65℃时加入食用香精、抑菌剂、甜味剂,继续保持此加热温度,调节搅拌速度为800r/min搅拌0.5h,再降温至45℃后加入天然植物提取物,搅拌0.5小时后形成胶浆; Step 1: Add the film-forming agent to deionized water, the weight ratio of the two is 1:3, stir while heating, and add the above friction agent, emulsifier, foaming detergent, thickener, and set the stirring speed 500r/min, when the temperature of the above mixture rises to 65°C, add edible essence, antibacterial agent, and sweetener, continue to maintain the heating temperature, adjust the stirring speed to 800r/min and stir for 0.5h, then cool down to 45°C and add natural plants Extract, form glue after stirring for 0.5 hours;
步骤2:将步骤1中所得的胶浆制成薄膜,并保证其由一定的厚度; Step 2: Make the glue obtained in step 1 into a film, and ensure that it has a certain thickness;
步骤3:将步骤2中所得的薄膜蒸干成膜,保证其水分含量在15%,冷却后切片获得所述的含有植物提取物漱口片。 Step 3: Evaporate the film obtained in step 2 to form a film, keep the water content at 15%, slice it after cooling, and obtain the mouthwash tablet containing plant extracts.
实施例2 Example 2
含有植物提取物漱口片,按成品干重各组分的重量百分比如下: Mouthwash tablets containing plant extracts, the weight percentage of each component according to the dry weight of the finished product is as follows:
天然植物提取物 8% Natural plant extracts 8%
成膜剂 30% Film former 30%
摩擦剂 13% Friction agent 13%
食用香精 4% Food flavor 4%
乳化剂 6% Emulsifier 6%
起泡清洁剂 10% Foaming Cleanser 10%
增稠剂 25% Thickener 25%
抑菌剂 3% Antibacterial agent 3%
甜味剂 1% Sweetener 1%
所述的天然植物提取物是粉末状的草珊瑚提取物以及粉末状的木兰提取物按8:4的比例混合而成; Described natural plant extract is formed by mixing powdery Coralia praecox extract and powdery Magnolia extract in a ratio of 8:4;
优选的,草珊瑚提取物中纯品含量为25%,木兰提取物中纯品含量为25%。 Preferably, the pure product content in the grass coral extract is 25%, and the pure product content in the magnolia extract is 25%.
所述的成膜剂为羟乙基纤维素中和壳聚糖、海藻酸钠、变性淀粉、普鲁兰、麦芽糊精、瓜尔胶、魔芋精粉中的一种或多种混合制成。 The film-forming agent is prepared by mixing one or more of hydroxyethyl cellulose and chitosan, sodium alginate, modified starch, pullulan, maltodextrin, guar gum, and konjac powder .
所述的摩擦剂通过二氧化硅、碳酸氢钙和碳酸钙以重量比为1:5:4比例混合制得。 The friction agent is prepared by mixing silicon dioxide, calcium bicarbonate and calcium carbonate at a weight ratio of 1:5:4.
所述的食用香精为竹香精以及能薄荷醇,通过竹香精和薄荷醇以重量比为2:1的比例混合制得。 The food flavor is bamboo flavor and menthol, which is prepared by mixing bamboo flavor and menthol at a weight ratio of 2:1.
所述的乳化剂为交联羧甲甲淀粉钠、泊洛沙姆、硬脂酸甘油脂以重量比为1:2:2的比例混合制得。 The emulsifier is prepared by mixing croscarmellose sodium, poloxamer, and glyceryl stearate in a weight ratio of 1:2:2.
所述的起泡清洁剂可选用月桂基三乙醇胺硫酸钠、月桂酰肌氨酸钠、十二烷基硫酸钠、月桂基谷氨酸钠中的一种或多种混合制得。 The foaming cleanser can be prepared by mixing one or more of sodium lauryl triethanolamine sulfate, sodium lauryl sarcosinate, sodium lauryl sulfate and sodium lauryl glutamate.
所述的增稠剂是环状糊精和倍他环糊精以重量比为1:3的形式混合制得。 The thickener is prepared by mixing cyclodextrin and beta-cyclodextrin in a weight ratio of 1:3.
所述的起泡清洁剂选择月桂基三乙醇胺硫酸钠、十二烷基硫酸钠、月桂基谷氨酸钠以重量比为1:3:2的比例混合制得。 The foaming cleaner is prepared by mixing sodium lauryl triethanolamine sulfate, sodium lauryl sulfate and sodium lauryl glutamate in a weight ratio of 1:3:2.
所述的甜味剂通过木糖醇和三氯蔗糖以3:1的比例混合制得。 The sweetener is prepared by mixing xylitol and sucralose in a ratio of 3:1.
本发明还提供了一种含有植物提取物漱口片及其制作方法,通过以下步骤制成: The present invention also provides a mouthwash tablet containing plant extracts and a preparation method thereof, which are made through the following steps:
步骤1:将成膜剂加入到去离子水中,两者的重量比为1:3,边加热边搅拌,并边加入上述摩擦剂、乳化剂、起泡清洁剂、增稠剂, 搅拌速度设置为500r/min,当以上混合物升温65℃时加入食用香精、抑菌剂、甜味剂,继续保持此加热温度,调节搅拌速度为800r/min搅拌0.5h,再降温至45℃后加入天然植物提取物,搅拌0.5小时后形成胶浆; Step 1: Add the film-forming agent to deionized water, the weight ratio of the two is 1:3, stir while heating, and add the above friction agent, emulsifier, foaming detergent, thickener, and set the stirring speed 500r/min, when the temperature of the above mixture rises to 65°C, add edible essence, antibacterial agent, and sweetener, continue to maintain the heating temperature, adjust the stirring speed to 800r/min and stir for 0.5h, then cool down to 45°C and add natural plants Extract, form glue after stirring for 0.5 hours;
步骤2:将步骤1中所得的胶浆制成薄膜,并保证其由一定的厚度; Step 2: Make the glue obtained in step 1 into a film, and ensure that it has a certain thickness;
步骤3:将步骤2中所得的薄膜蒸干成膜,保证其水分含量在15%,冷却后切片获得所述的含有植物提取物漱口片。 Step 3: Evaporate the film obtained in step 2 to form a film, keep the water content at 15%, slice it after cooling, and obtain the mouthwash tablet containing plant extracts.
实施例3 Example 3
含有植物提取物漱口片,按成品干重各组分的重量百分比如下: Mouthwash tablets containing plant extracts, the weight percentage of each component according to the dry weight of the finished product is as follows:
天然植物提取物 15% Natural plant extracts 15%
成膜剂 20% Film former 20%
摩擦剂 15% Friction agent 15%
食用香精 14% Food flavor 14%
乳化剂 10% Emulsifier 10%
起泡清洁剂 6% Foaming Cleanser 6%
增稠剂 15% Thickener 15%
抑菌剂 2% Antibacterial agent 2%
甜味剂 3% Sweetener 3%
所述的天然植物提取物是粉末状的草珊瑚提取物以及粉末状的木兰提取物按10:5的比例混合而成; Described natural plant extract is formed by mixing powdery Coralia praecox extract and powdery Magnolia extract in a ratio of 10:5;
优选的,草珊瑚提取物中纯品含量为40%,木兰提取物中纯品含量为40%。 Preferably, the pure product content in the grass coral extract is 40%, and the pure product content in the magnolia extract is 40%.
所述的成膜剂使用羟丙基纤维素与壳聚糖、海藻酸钠、变性淀粉、普鲁兰、麦芽糊精、瓜尔胶、魔芋精粉中的一种或多种混合制成。 The film-forming agent is prepared by mixing one or more of hydroxypropyl cellulose and chitosan, sodium alginate, modified starch, pullulan, maltodextrin, guar gum, and konjac powder.
所述的摩擦剂通过二氧化硅、碳酸氢钙和碳酸钙以重量比为1:5:4比例混合制得。 The friction agent is prepared by mixing silicon dioxide, calcium bicarbonate and calcium carbonate at a weight ratio of 1:5:4.
所述的食用香精为竹香精以及能薄荷醇,通过竹香精和薄荷醇以重量比为2:1的比例混合制得。 The food flavor is bamboo flavor and menthol, which is prepared by mixing bamboo flavor and menthol at a weight ratio of 2:1.
所述的乳化剂为交联羧甲甲淀粉钠、泊洛沙姆、硬脂酸甘油脂以重量比为1:2:2的比例混合制得。 The emulsifier is prepared by mixing croscarmellose sodium, poloxamer, and glyceryl stearate in a weight ratio of 1:2:2.
所述的起泡清洁剂选择月桂基三乙醇胺硫酸钠、十二烷基硫酸钠、月桂基谷氨酸钠以重量比为1:3:2的比例混合制得。 The foaming cleaner is prepared by mixing sodium lauryl triethanolamine sulfate, sodium lauryl sulfate and sodium lauryl glutamate in a weight ratio of 1:3:2.
所述的增稠剂是环状糊精和倍他环糊精以重量比为1:3的形式混合制得。 The thickener is prepared by mixing cyclodextrin and beta-cyclodextrin in a weight ratio of 1:3.
所述的抑菌剂为醋酸洗必泰、2,4,4’-三氯2’-羟基二苯醚、氯化十六烷基吡啶混合制成。 The bacteriostatic agent is prepared by mixing chlorhexidine acetate, 2,4,4'-trichloro 2'-hydroxydiphenyl ether and cetylpyridinium chloride.
所述的甜味剂通过木糖醇和三氯蔗糖以3:1的比例混合制得。 The sweetener is prepared by mixing xylitol and sucralose in a ratio of 3:1.
本发明还提供了一种含有植物提取物漱口片及其制作方法,通过以下步骤制成: The present invention also provides a mouthwash tablet containing plant extracts and a preparation method thereof, which are made through the following steps:
步骤1:将成膜剂加入到去离子水中,两者的重量比为1:3,边加热边搅拌,并边加入上述摩擦剂、乳化剂、起泡清洁剂、增稠剂, 搅拌速度设置为500r/min,当以上混合物升温65℃时加入食用香精、抑菌剂、甜味剂,继续保持此加热温度,调节搅拌速度为800r/min搅拌0.5h,再降温至45℃后加入天然植物提取物,搅拌0.5小时后形成胶浆; Step 1: Add the film-forming agent to deionized water, the weight ratio of the two is 1:3, stir while heating, and add the above friction agent, emulsifier, foaming detergent, thickener, and set the stirring speed 500r/min, when the temperature of the above mixture rises to 65°C, add edible essence, antibacterial agent, and sweetener, continue to maintain the heating temperature, adjust the stirring speed to 800r/min and stir for 0.5h, then cool down to 45°C and add natural plants Extract, form glue after stirring for 0.5 hours;
步骤2:将步骤1中所得的胶浆制成薄膜,并保证其由一定的厚度; Step 2: Make the glue obtained in step 1 into a film, and ensure that it has a certain thickness;
步骤3:将步骤2中所得的薄膜蒸干成膜,保证其水分含量在18%,冷却后切片获得所述的含有植物提取物漱口片。 Step 3: Evaporate the film obtained in step 2 to form a film to ensure that its moisture content is 18%, slice it after cooling to obtain the mouthwash tablet containing plant extracts.
优选的,将冷却后的薄膜切割为50mm×40mm×0.2mm的切片。 Preferably, the cooled film is cut into slices of 50mm×40mm×0.2mm.
实施例4 Example 4
含有植物提取物漱口片,按成品干重各组分的重量百分比如下: Mouthwash tablets containing plant extracts, the weight percentage of each component according to the dry weight of the finished product is as follows:
天然植物提取物 9% Natural plant extracts 9%
成膜剂 20% Film former 20%
摩擦剂 25% Friction agent 25%
食用香精 16% Food flavor 16%
乳化剂 7% Emulsifier 7%
起泡清洁剂 5% Foaming Cleanser 5%
增稠剂 15% Thickener 15%
抑菌剂 1% Antibacterial agent 1%
甜味剂 2% Sweetener 2%
所述的天然植物提取物是粉末状的草珊瑚提取物以及粉末状的木兰提取物按10:5的比例混合而成; Described natural plant extract is formed by mixing powdery Coralia praecox extract and powdery Magnolia extract in a ratio of 10:5;
优选的,草珊瑚提取物中纯品含量为50%,木兰提取物中纯品含量为50%。 Preferably, the pure product content in the grass coral extract is 50%, and the pure product content in the magnolia extract is 50%.
所述的成膜剂选用羧甲基纤维素、羟乙基纤维素、羟丙基纤维素以重量比为1:2:3和壳聚糖、海藻酸钠、变性淀粉、普鲁兰、麦芽糊精、瓜尔胶、魔芋精粉中的一种或多种混合制成。 Described film-forming agent selects carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose with weight ratio as 1:2:3 and chitosan, sodium alginate, modified starch, pullulan, malt It is made by mixing one or more of dextrin, guar gum, and konjac powder.
所述的摩擦剂通过二氧化硅、碳酸氢钙和碳酸钙以重量比为1:5:4比例混合制得。 The friction agent is prepared by mixing silicon dioxide, calcium bicarbonate and calcium carbonate at a weight ratio of 1:5:4.
所述的食用香精为竹香精以及能薄荷醇,通过竹香精和薄荷醇以重量比为2:1的比例混合制得。 The food flavor is bamboo flavor and menthol, which is prepared by mixing bamboo flavor and menthol at a weight ratio of 2:1.
所述的乳化剂为交联羧甲甲淀粉钠、泊洛沙姆、硬脂酸甘油脂以重量比为1:2:2的比例混合制得。 The emulsifier is prepared by mixing croscarmellose sodium, poloxamer, and glyceryl stearate in a weight ratio of 1:2:2.
所述的起泡清洁剂选择月桂基三乙醇胺硫酸钠、十二烷基硫酸钠、月桂基谷氨酸钠以重量比为1:3:2的比例混合制得。 The foaming cleaner is prepared by mixing sodium lauryl triethanolamine sulfate, sodium lauryl sulfate, and sodium lauryl glutamate in a weight ratio of 1:3:2.
所述的增稠剂是环状糊精和倍他环糊精以重量比为1:3的形式混合制得。 The thickener is prepared by mixing cyclodextrin and beta-cyclodextrin in a weight ratio of 1:3.
所述的抑菌剂为醋酸洗必泰、2,4,4’-三氯2’-羟基二苯醚、氯化十六烷基吡啶按重量比例为1:1:14混合制成。 The bacteriostatic agent is prepared by mixing chlorhexidine acetate, 2,4,4'-trichloro 2'-hydroxydiphenyl ether, and cetylpyridinium chloride in a weight ratio of 1:1:14.
所述的甜味剂通过木糖醇和三氯蔗糖以3:1的比例混合制得。 The sweetener is prepared by mixing xylitol and sucralose in a ratio of 3:1.
本发明还提供了一种含有植物提取物漱口片及其制作方法,通过以下步骤制成: The present invention also provides a mouthwash tablet containing plant extracts and a preparation method thereof, which are made through the following steps:
步骤1:将成膜剂加入到去离子水中,两者的重量比为1:3,边加热边搅拌,并边加入上述摩擦剂、乳化剂、起泡清洁剂、增稠剂, 搅拌速度设置为500r/min,当以上混合物升温65℃时加入食用香精、抑菌剂、甜味剂,继续保持此加热温度,调节搅拌速度为800r/min搅拌0.5h,再降温至45℃后加入天然植物提取物,搅拌0.5小时后形成胶浆; Step 1: Add the film-forming agent to deionized water, the weight ratio of the two is 1:3, stir while heating, and add the above friction agent, emulsifier, foaming detergent, thickener, and set the stirring speed 500r/min, when the temperature of the above mixture rises to 65°C, add edible essence, antibacterial agent, and sweetener, continue to maintain the heating temperature, adjust the stirring speed to 800r/min and stir for 0.5h, then cool down to 45°C and add natural plants Extract, form glue after stirring for 0.5 hours;
步骤2:将步骤1中所得的胶浆制成薄膜,并保证其由一定的厚度; Step 2: Make the glue obtained in step 1 into a film, and ensure that it has a certain thickness;
步骤3:将步骤2中所得的薄膜蒸干成膜,保证其水分含量在18%,冷却后切片获得所述的含有植物提取物漱口片。 Step 3: Evaporate the film obtained in step 2 to form a film to ensure that its water content is 18%, slice it after cooling to obtain the mouthwash tablet containing plant extracts.
优选的,将冷却后的薄膜切割为50mm×40mm×0.2mm的切片。 Preferably, the cooled film is cut into slices of 50mm×40mm×0.2mm.
实施例5 Example 5
含有植物提取物漱口片,按成品干重各组分的重量百分比如下: Mouthwash tablets containing plant extracts, the weight percentage of each component according to the dry weight of the finished product is as follows:
天然植物提取物 9% Natural plant extracts 9%
成膜剂 20% Film former 20%
摩擦剂 25% Friction agent 25%
食用香精 16% Food flavor 16%
乳化剂 7% Emulsifier 7%
起泡清洁剂 5% Foaming Cleanser 5%
增稠剂 15% Thickener 15%
抑菌剂 1% Antibacterial agent 1%
甜味剂 2% Sweetener 2%
所述的天然植物提取物是粉末状的草珊瑚提取物以及粉末状的木兰提取物按10:5的比例混合而成; Described natural plant extract is formed by mixing powdery Coralia praecox extract and powdery Magnolia extract in a ratio of 10:5;
优选的,草珊瑚提取物中纯品含量为50%,木兰提取物中纯品含量为50%。 Preferably, the pure product content in the grass coral extract is 50%, and the pure product content in the magnolia extract is 50%.
所述的成膜剂为羧甲基纤维素、羟乙基纤维素、羟丙基纤维素以重量比为1:2:3和壳聚糖、普鲁兰、麦芽糊精以重量比为1:1:1的比例混合制得。 Described film-forming agent is that carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose are 1:2:3 with weight ratio and chitosan, pullulan, maltodextrin are 1 with weight ratio : Prepared by mixing in a ratio of 1:1.
所述的摩擦剂通过二氧化硅、碳酸氢钙和碳酸钙以重量比为1:5:4比例混合制得。 The friction agent is prepared by mixing silicon dioxide, calcium bicarbonate and calcium carbonate at a weight ratio of 1:5:4.
所述的食用香精为竹香精以及能薄荷醇,通过竹香精和薄荷醇以重量比为2:1的比例混合制得。 The food flavor is bamboo flavor and menthol, which is prepared by mixing bamboo flavor and menthol at a weight ratio of 2:1.
所述的乳化剂为交联羧甲甲淀粉钠、泊洛沙姆、硬脂酸甘油脂以重量比为1:2:2的比例混合制得。 The emulsifier is prepared by mixing croscarmellose sodium, poloxamer, and glyceryl stearate in a weight ratio of 1:2:2.
所述的起泡清洁剂选择月桂基三乙醇胺硫酸钠、十二烷基硫酸钠、月桂基谷氨酸钠以重量比为1:3:2的比例混合制得。 The foaming cleaner is prepared by mixing sodium lauryl triethanolamine sulfate, sodium lauryl sulfate and sodium lauryl glutamate in a weight ratio of 1:3:2.
所述的增稠剂是环状糊精和倍他环糊精以重量比为1:3的形式混合制得。 The thickener is prepared by mixing cyclodextrin and beta-cyclodextrin in a weight ratio of 1:3.
所述的抑菌剂为醋酸洗必泰、2,4,4’-三氯2’-羟基二苯醚、氯化十六烷基吡啶按重量比例为1:1:1混合制成。 The bacteriostatic agent is prepared by mixing chlorhexidine acetate, 2,4,4'-trichloro 2'-hydroxydiphenyl ether, and cetylpyridinium chloride in a weight ratio of 1:1:1.
所述的甜味剂通过木糖醇和三氯蔗糖以3:1的比例混合制得。 The sweetener is prepared by mixing xylitol and sucralose in a ratio of 3:1.
本发明还提供了一种含有植物提取物漱口片及其制作方法,通过以下步骤制成: The present invention also provides a mouthwash tablet containing plant extracts and a preparation method thereof, which are made through the following steps:
步骤1:将成膜剂加入到去离子水中,两者的重量比为1:3,边加热边搅拌,并边加入上述摩擦剂、乳化剂、起泡清洁剂、增稠剂, 搅拌速度设置为500r/min,当以上混合物升温65℃时加入食用香精、抑菌剂、甜味剂,继续保持此加热温度,调节搅拌速度为800r/min搅拌0.5h,再降温至45℃后加入天然植物提取物,搅拌0.5小时后形成胶浆; Step 1: Add the film-forming agent to deionized water, the weight ratio of the two is 1:3, stir while heating, and add the above friction agent, emulsifier, foaming detergent, thickener, and set the stirring speed 500r/min, when the temperature of the above mixture rises to 65°C, add edible essence, antibacterial agent, and sweetener, continue to maintain the heating temperature, adjust the stirring speed to 800r/min and stir for 0.5h, then cool down to 45°C and add natural plants Extract, form glue after stirring for 0.5 hours;
步骤2:将步骤1中所得的胶浆制成薄膜,并保证其由一定的厚度; Step 2: Make the glue obtained in step 1 into a film, and ensure that it has a certain thickness;
步骤3:将步骤2中所得的薄膜蒸干成膜,保证其水分含量在18%,冷却后切片获得所述的含有植物提取物漱口片。 Step 3: Evaporate the film obtained in step 2 to form a film to ensure that its water content is 18%, slice it after cooling to obtain the mouthwash tablet containing plant extracts.
优选的,将冷却后的薄膜切割为50mm×40mm×0.2mm的切片。 Preferably, the cooled film is cut into slices of 50mm×40mm×0.2mm.
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105410913A (en) * | 2015-12-01 | 2016-03-23 | 辽宁三合酒业有限公司 | Preparation method of chitosan oligosaccharide mouth cleaning buccal tablets |
CN106344428A (en) * | 2016-07-27 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Marine polysaccharide-based dry mouth symptom relieving mouthwash and preparation method thereof |
US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
CN115282076A (en) * | 2022-07-28 | 2022-11-04 | 广州洁生日化有限公司 | Oral care cleaning tablet and preparation method and use method thereof |
US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
CN116942587A (en) * | 2023-07-13 | 2023-10-27 | 安徽聚塑高科实业有限公司 | Edible lipstick and preparation method thereof |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1119541A (en) * | 1995-04-25 | 1996-04-03 | 卢建中 | Gargle made of sarcandra glabra |
CN101132806A (en) * | 2004-12-29 | 2008-02-27 | 高露洁-棕榄公司 | Method of reducing oral tissue inflammation using magnolia extract |
CN101185613A (en) * | 2007-12-18 | 2008-05-28 | 美晨集团股份有限公司 | Gargle tablet and preparation method thereof |
CN101455620A (en) * | 2007-12-13 | 2009-06-17 | 王惠明 | Gargle tablet composition and preparation method thereof |
-
2014
- 2014-12-02 CN CN201410716890.6A patent/CN104473822A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1119541A (en) * | 1995-04-25 | 1996-04-03 | 卢建中 | Gargle made of sarcandra glabra |
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