CN104472501A - Synergism weeding composition - Google Patents

Abstract

The invention discloses a synergistic herbicidal pesticide composition, which contains 2-(6-fluoro-2-pyridyloxy)-N-(4-fluorophenyl)-N-(1-methylethyl)sulfur Acetamide (TAM-5) and atrazine are active ingredients, which are composed of acceptable auxiliary ingredients in pesticides, wherein the weight ratio of TAM-5 and atrazine is 50:1 to 1:100. The combination of the two active ingredients forms a synergistic effect, and can expand the herbicidal spectrum without antagonistic effect, thereby improving the safety of crops. The synergistic herbicidal pesticide composition can effectively control annual grass weeds and broad-leaved weeds, and can also inhibit some perennial weeds. It can be used for weeding in corn fields, sugarcane fields, rapeseed fields, tea gardens and other farmlands and non-cultivated lands. Improve the weeding effect and reduce the cost.

Description

synergistic herbicidal composition

technical field

The invention relates to a herbicidal pesticide composition, which is especially used for weeding in sugarcane fields, corn fields, rapeseed fields, tea gardens and other farmlands and non-cultivated lands.

Background technique

There are many weeds in sugarcane fields, corn fields, rapeseed fields, tea gardens and other farmlands and non-cultivated lands. Take common cornfield weeds as an example, including barnyardgrass, crabgrass, velvet hemp, amaranth, goosegrass, teff, green foxtail, golden foxtail and so on. Among the common weeds in cornfields, there are not only annual weeds but also perennial weeds, and these weeds have multiple grassing periods, so it is difficult to control. At present, glyphosate, glufosinate, acetochlor, and bikgrass, which are most commonly used in agricultural production, are prone to phytotoxicity. At the same time, most of the above-mentioned commonly used herbicides have high requirements on the age of the weeds when they are applied. If the age of the weeds exceeds a certain range, the weeding effect will be significantly reduced. Glyphosate and glufosinate-ammonium herbicides are mostly only suitable for weeding in non-cultivated land.

Chinese patent (application number CN2013100125604, application date January 15, 2013) reported that the patent applicant is Xihua University (the inventors are Yang Weiqing, Ma Menglin, etc.) and the general formula is TAM 2-pyridyloxy-N-disubstituted Thioacetamide compound and its synthesis method (Formula 1). Chinese patent (application number CN2013100201913, application date January 21, 2013) reported that the patent applicant is Xihua University (inventors are Yang Weiqing, Zhang Yuanyuan, etc.) to 2-pyridyloxy-N-disubstituted with the general formula TAM A new synthesis method of thioacetamide compounds is reported. This new method adopts the transesterification method for the synthesis of the target product and has achieved good results. Chinese patent (application number CN2013100201928, application date January 21, 2013) reported that the patent applicant is Xihua University (the inventors are Yang Weiqing, Zhang Yuanyuan, etc.) and the general formula is TAM 2-pyridyloxy-N-disubstituted The use of thioacetamide compounds as herbicides is mainly used for broadleaf weeds and gramineous weeds in farmland. Among the compounds with the general formula TAM , TAM-5 (Formula 2) has the best herbicidal activity and can effectively control annual gramineous weeds and broad-leaved weeds, but it can only exert a limited inhibitory effect on some perennial weeds. Herbicidal spectrum is not broad enough.

Atrazine belongs to the family of triazine herbicides and has become a more commonly used herbicide in the United States in the late 1990s. The chemical name of atrazine is 2-chloro-4-diethylamino-6-isopropylamino-1,3,5-triazine, and its structural formula is shown in formula 3. Other commonly used names for atrazine include: Atrazine, Aatrex, Primatola, etc. Atrazine is a systemic herbicide, mainly absorbed through the roots of plants and conducted upwards, inhibiting the photosynthesis of weeds (such as cocklebur, foxtail, ragweed and wild cucumber, etc.), making it dead. It can be used for pre-emergence weeding or post-emergence weeding. The absorption of atrazine was mainly in the roots, and the absorption in stems and leaves was very little. Widely used in corn fields, etc., because atrazine can be decomposed into non-toxic substances by corn ketolase in resistant crops such as corn, so it is safe for corn crops. Atrazine can control a variety of annual grasses and broadleaf weeds. Suitable for corn, sorghum, sugarcane, fruit trees, nurseries, woodland and other upland crops to control crabgrass, barnyardgrass, foxtail, sedge, alopecia, Polygonum, Chenopodium, cruciferous, leguminous weeds, especially for corn Good selectivity (due to the detoxifying corn ketone enzyme in corn), it also has a certain inhibitory effect on some perennial weeds. Drought has a greater impact on the efficacy of the drug during use, and it mainly acts on dicotyledonous plants, focusing on closure, and the effect on weeds with older weeds is not ideal.

Contents of the invention

In view of the above situation, the present invention will report a kind of efficient and safe herbicide pesticide that can effectively control annual gramineous weeds and broad-leaved weeds, and can suppress some perennial weeds, and can be used in cornfields, sugarcane fields, rape fields, etc. Fields, tea gardens and other farmland and non-cultivated land weeding.

The herbicidal composition of the present invention is 2-(6-fluoro-2-pyridyloxy)-N-(4-fluorophenyl)-N-(1-methylethyl)thioacetamide [English Name is (N-(4-fluorophenyl)-N-isopropylthiocarbamoyl)methyl 6-fluoro ropyridine-2-carboxylate; Structural formula is as shown in formula 2; Hereinafter referred to as TAM-5 in the present invention] compound and atrazine (formula 3 The structural formula shown) is the active ingredient, which is composed of acceptable auxiliary ingredients in the pesticide.

The allowable weight ratio of TAM-5 and atrazine in the herbicidal composition of the present invention is 50:1 to 1:100, the better ratio is 20:1 to 1:30, and the preferred ratio is 2:1 to 1:10.

Acceptable auxiliary components in said pesticides include various common solvents and/or inert fillers and/or surfactants and/or preservatives and/or antifreezes that have been used in pesticides and will not have adverse effects and / or anti-caking agent and / or antifoaming agent and / or co-solvent and / or stabilizer and / or thickener and other corresponding additive components, and can be selected or adjusted according to the preparation form produced.

Agrochemical formulations generally contain 0.1-99% by weight, in particular 2-90% by weight, of the herbicidal compositions according to the invention. The herbicidal composition concentration in wettable powders (WP) is, for example, 10-90% by weight, the remainder of 100% by weight consisting of customary formulation auxiliaries. The concentration of the herbicidal composition in the suspension concentrate (SC) is, for example, 1-90% by weight, preferably 5-75% by weight, the remainder of 100% by weight consisting of customary formulation auxiliaries. The concentration of the herbicidal composition in the suspoemulsion (SE) is, for example, 1-90% by weight, preferably 5-75% by weight, the remainder of 100% by weight consisting of customary formulation auxiliaries. The concentration of the herbicidal composition in the water dispersant (WDG) is, for example, 1-95% by weight, preferably 10-70% by weight, the remainder of 100% by weight consisting of customary formulation auxiliaries. Other formulations in powder form comprise 1-40% by weight of active compound, preferably 5-20% by weight of active compound, the remainder of 100% by weight consisting of customary formulation auxiliaries.

The herbicidal composition of the present invention is prepared by fully mixing the active ingredients of TAM-5 and atrazine and the corresponding auxiliary ingredients in the herbicidal composition according to different use needs or application environments/conditions through the current conventional pesticide production methods. Corresponding dosage forms are available in different forms. Possible dosage forms include: wettable powder, water dispersion, suspension, water emulsion, suspoemulsion, microcapsules and the like. For example, several typical commonly used preparations and preparations can be:

Water dispersant (WDG) is a granular preparation that can disintegrate quickly in water and can be uniformly dispersed in water to form a high-suspension dispersion system. During preparation, the composition of the present invention and auxiliary components can be pulverized or ultra-finely pulverized by airflow to make wettable powder, which is a dry method; the composition of the present invention, auxiliary agents, auxiliary agents, etc. Grind in a sand mill to make a suspension, and then dry and granulate, which is a wet method.

Wettable powder (WP), that is, a solid powder preparation that can be uniformly dispersed in water. During preparation, according to conventional methods, first add the composition of the present invention whose general formula is TAM , then add common diluents or inert substances such as diatomaceous earth, pottery clay, light calcium carbonate, white carbon black, and then add other commonly used auxiliary components , such as alkyl naphthalene sulfonate, alkylbenzene sulfonate, fatty alcohol sulfate, alkyl ammonium bromide, alkyl ammonium chloride, quaternary phosphonium salt, alkyl polyoxyethylene ether sulfate, lignin sulfonate salt, lignin, carboxymethyl cellulose, sodium carboxymethyl cellulose, azone, thione, or one or more of them, as well as auxiliary additives such as commonly used stabilizers, foam inhibitors, and anti-caking agents Element.

Suspoemulsion (SE) is a mixed dispersion of water-insoluble pesticides in water, in which one active ingredient is in a suspended state and the other active ingredients are in an emulsion state. During preparation, the composition of the present invention and corresponding emulsions, wetting and dispersing agents, thickeners, stabilizers, antifreeze agents, pH regulators, defoamers and other auxiliary components can be prepared according to conventional methods through wet ultramicro Made by crushing and mixing. Among them, the emulsifiers are alkylphenol polyoxyethylene ethers (Nongru 100#), alkylbenzene sulfonate (Nongru 500#), phenylethylphenol polyoxyethylene ethers (Nongru 600#), alkyl One or more of phenol or aralkylphenol polyoxyethylene ether formaldehyde condensate (Nongru 700#), etc. Among them, the wetting and dispersing agent is lignosulfonate, lignin, phosphate polyether, carboxymethylcellulose, sodium carboxymethylcellulose, crown ether, alkylnaphthalenesulfonate, alkylbenzenesulfonate, One or more of fatty alcohol sulfates, alkyl ammonium halides, quaternary phosphonium salts, alkyl polyoxyethylene ether sulfates, azone, and thioketone; thickeners and stabilizers are polyvinyl alcohol, condensed phosphoric acid One or more of salt, xanthan gum, aluminum magnesium silicate, etc.; antifreeze is one or more of sodium chloride, urea, ammonium sulfate, ethylene glycol, glycerin, etc.; pH regulator is One or more of potassium dihydrogen phosphate, dipotassium hydrogen phosphate, citric acid, sodium carbonate, potassium carbonate, etc. Silicones are commonly used as defoamers and foam suppressors.

Suspension concentrate (SC), namely pesticide suspension concentrate (SC), is a dispersion of water-insoluble solid pesticide or immiscible liquid pesticide in water or oil. During preparation, water or oil is used as a dispersion medium, and the composition of the present invention whose general formula is TAM and auxiliary components (such as thickener, stabilizer, wetting and dispersing agent, antifreeze agent, pH regulator, defoamer, etc.) Wet ultrafine grinding (grinding) in the system. Among them, the wetting and dispersing agents are phosphate polyethers, alkyl naphthalene sulfonates, alkyl benzene sulfonates, fatty alcohol sulfates, alkyl ammonium bromides, alkyl ammonium chlorides, crown ethers, quaternary phosphonium salts, alkanes One or more of base polyoxyethylene ether sulfate, lignosulfonate, lignin, carboxymethyl cellulose, sodium carboxymethyl cellulose, azone, thione; thickener and stabilizer It is one or more of polyvinyl alcohol, condensed phosphate, xanthan gum, aluminum magnesium silicate, etc.; the antifreeze is one or more of sodium chloride, urea, ammonium sulfate, ethylene glycol, glycerin, etc. Several kinds; the pH adjuster is one or more of potassium dihydrogen phosphate, dipotassium hydrogen phosphate, citric acid, sodium carbonate, potassium carbonate, etc. Silicones are commonly used as defoamers and foam suppressors.

It should be noted that the specific dosage forms mentioned above are representative dosage forms in which the composition of the present invention can be formulated, and the list is not limited to these dosage forms mentioned above.

The above-mentioned content of the present invention will be further described in detail below by means of specific examples. However, this should not be construed as limiting the scope of the above-mentioned subject matter of the present invention to the following examples. Without departing from the above-mentioned technical idea of the present invention, various replacements or changes made according to common technical knowledge and customary means in this field shall be included in the scope of the present invention. The composition ratios of each material in the examples are % by weight.

Detailed ways:

Example 1: 30% herbicidal composition TAM -5·atrazine suspension concentrate (SC)

Composition: TAM -5 20% (wt%, the same for the present invention below)

Atrazine 10%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Magnesium Aluminum Silicate 2%

Sodium dodecylbenzenesulfonate 2%

Ethylene Glycol 3%

                                            

Preparation: put each material into the reaction kettle in turn, use a high-speed shearing machine for initial dispersion, and then grind in a sand mill until the particle size of the active ingredient is 2-5 μm.

Example 2: 20% herbicidal composition TAM -5 Atrazine suspension concentrate (SC)

Composition: TAM -5 10%

Atrazine 10%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Magnesium Aluminum Silicate 2%

Sodium dodecylbenzenesulfonate 2%

Ethylene Glycol 3%

                                            

Preparation: put each material into the reaction kettle in turn, use a high-speed shearing machine for initial dispersion, and then grind in a sand mill until the particle size of the active ingredient is 2-5 μm.

Example 3: 40% herbicidal composition TAM -5 Atrazine suspension concentrate (SC)

Composition: TAM -5 30%

Atrazine 10%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Magnesium Aluminum Silicate 2%

Sodium dodecylbenzenesulfonate 2%

Ethylene Glycol 3%

                                            

Preparation: put each material into the reaction kettle in turn, use a high-speed shearing machine for initial dispersion, and then grind in a sand mill until the particle size of the active ingredient is 2-5 μm.

Example 4: 20% herbicidal composition TAM -5·atrazine suspension concentrate (SC)

Composition: TAM -5 15%

Atrazine 5%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Magnesium Aluminum Silicate 2%

Sodium dodecylbenzenesulfonate 2%

Ethylene Glycol 3%

                                            

Preparation: put each material into the reaction kettle in turn, use a high-speed shearing machine for initial dispersion, and then grind in a sand mill until the particle size of the active ingredient is 2-5 μm.

Example 5: 30% herbicidal composition TAM -5 Atrazine suspension concentrate (SC)

Composition: TAM -5 15%

Atrazine 15%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Magnesium Aluminum Silicate 2%

Sodium dodecylbenzenesulfonate 2%

Ethylene Glycol 3%

                                            

Preparation: put each material into the reaction kettle in turn, use a high-speed shearing machine for initial dispersion, and then grind in a sand mill until the particle size of the active ingredient is 2-5 μm.

Example 6: 10% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 5%

Atrazine 5%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 7: 15% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 10%

Atrazine 5%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 8: 20% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 15%

Atrazine 5%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 9: 20% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 10%

Atrazine 10%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 10: 25% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 15%

Atrazine 10%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 11: 25% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 20%

Atrazine 5%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 12: 30% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 20%

Atrazine 10%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 13: 30% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 10%

Atrazine 20%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 14: 30% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 15%

Atrazine 15%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 15: 40% herbicidal composition TAM -5·atrazine wettable powder (WP)

Composition: TAM -5 20%

Atrazine 20%

Lignosulfonate Calcium 3%

  Sodium Carboxymethyl Cellulose 3%

Sodium dodecylbenzenesulfonate 2%

Tetrabutylammonium bromide 2%

    Kaolin     Make up to 100%

Preparation: Add each material into the reaction kettle in turn, stir to make it fully mixed, and crush to 5-20 μm.

Example 16: 30% herbicidal composition TAM -5·atrazine water dispersible granules

Composition: TAM -5 20%

Atrazine 10%

Lignin 5%

Acrylic branch polymer 4%

Sodium Lauryl Sulfonate 3%

                                                       

                                                                                              

Preparation: put each material into the reaction kettle in turn, mix evenly, then grind in a sand mill, add appropriate amount of water, granulate, and dry to obtain dispersible granules.

Example 17: 40% herbicidal composition TAM -5·atrazine water dispersible granules

Composition: TAM -5 25%

Atrazine 15%

Lignin 5%

Acrylic branch polymer 4%

Sodium Lauryl Sulfonate 3%

                                                       

                                                                                              

Preparation: put each material into the reaction kettle in turn, mix evenly, then grind in a sand mill, add appropriate amount of water, granulate, and dry to obtain dispersible granules.

Example 18: 40% active compound ( TAM -5) wettable powder (WP)

Composition: TAM -5 40%

    Calcium Lignosulfonate 8%

  Sodium Carboxymethyl Cellulose 5%

Sodium dodecylbenzenesulfonate 6%

Tetrabutylammonium bromide 4%

Kaolin 37%

Example 19: 30% atrazine suspension concentrate (SC)

Composition: Atrazine 30%

Atrazine 10%

    Calcium Lignosulfonate 3%

  Sodium Carboxymethyl Cellulose 3%

Magnesium Aluminum Silicate 2%

Sodium dodecylbenzenesulfonate 2%

Ethylene Glycol 3%

                                            

Preparation: put each material into the reaction kettle one by one, use a high-speed shearing machine for initial dispersion, and then grind in a sand mill until the particle size of the active ingredient is 2-5 μm.

The following experiments can show that the compounding of the two active ingredients TAM -5 and atrazine in the herbicidal composition of the present invention can have obvious synergistic effect.

In herbicide studies, a synergistic effect is indicated when the herbicidal activity of a combination of active compounds exceeds the activity of each active compound applied alone.

The budgeted activity of a given combination of two herbicides can be calculated as follows (Reference: Authors Colby, S.R. et al., Journal Name Weed, Issue 1, 1967, P20-22)

When X=% In the case of p kg/ha application rate, herbicide A (active compound A) damage rate,

And Y=% When the application rate is q kg/ha, the herbicide B (active compound B) damage rate,

And E=% The expected damage rate of herbicides A and B when the application rate is p and q kg/ha, then:

E=X+Y-X*Y/100

If the actual damage exceeds the calculated value, the activity of the composition is superadditive, ie synergistic.

1. Pot experiment

40% active compound ( TAM -5) wettable powder (WP) (prepared according to Example 18 of the present invention), 30% atrazine suspension concentrate (SC) (prepared according to Example 19 of the present invention) and compounded Table 1 shows the results of indoor toxicity tests on gramineous weeds and broad-leaved weeds (Amaranth 2-4 leaf stage, Goosegrass 2-4 leaf stage).

Table 1 Herbicidal activity effect of pot experiment

The experimental results in Table 1 show that the combination of the active compound ( TAM -5) and atrazine has obvious synergistic effect.

2. Field efficacy experiment

At the 2-3 leaf stage of direct-seeding corn and the 2-4 leaf stage of weeds, use 40% active compound ( TAM -5) wettable powder (WP) (prepared according to Example 18 of the present invention), 30% atrazine Suspension concentrate (SC) (prepared according to Example 19 of the present invention) and 40% of the herbicidal composition TAM -5·atrazine wettable powder (WP) (prepared according to Example 15 of the present invention) are effective against weeds in cornfields effect experiment. The control effect of fresh weight and 5% significant level of investigation 30 days after the drug are shown in Table 2.

Table 2 Results of field trials on controlling weeds in cornfields

The experimental results in Table 2 show that the compounding of TAM -5 and atrazine in the composition of the present invention can form a synergistic effect, and can expand the herbicidal spectrum without antagonism, improves the safety of crops, and significantly improves the herbicidal effect. effect, reducing costs.

Claims (5)

1. Herbicidal combinations, with 2-(the fluoro-2-pyridine acyloxy of 6-)-N-(4-fluorophenyl)-N-(1-Methylethyl) thioacetamide (TAM-5) and atrazine for active ingredient, jointly form with acceptable auxiliary element in agricultural chemicals, wherein TAM-5 and atrazine part by weight are 50:1 to 1:100.

2. Herbicidal combinations as claimed in claim 1, is characterized in that described active ingredient 2-(the fluoro-2-pyridine acyloxy of 6-)-N-(4-fluorophenyl)-N-(1-Methylethyl) thioacetamide (TAM-5) and atrazine part by weight are 20:1 to 1:30.

3. Herbicidal combinations as claimed in claim 1, is characterized in that described active ingredient 2-(the fluoro-2-pyridine acyloxy of 6-)-N-(4-fluorophenyl)-N-(1-Methylethyl) thioacetamide (TAM-5) and atrazine part by weight are 2:1 to 1:10.

4. herbicidal composition as claimed in claim 1, by the current conventional pesticide mode of production, preparation becomes any one formulation in the multi-form preparation formulation such as operational wetting powder, water dispersant, suspending agent, aqueous emulsion, suspension emulsion, microcapsule formulations.

5. as claimed in claim 1 in herbicidal composition, 2-(the fluoro-2-pyridine acyloxy of 6-)-N-(4-fluorophenyl)-N-(1-Methylethyl) thioacetamide (TAM-5) can by compound 2-(6-Chloro-2-Pyridyle acyloxy)-N-(4-fluorophenyl)-N-(1-Methylethyl) thioacetamide with TAM-5 similar, 2-(6-bromo-2-pyridyl acyloxy)-N-(4-fluorophenyl)-N-(1-Methylethyl) thioacetamide, the replacements such as 2-(the fluoro-2-pyridine acyloxy of 6-)-N-(4-fluorophenyl)-N-n-pro-pyl thioacetamide.