CN104458587B - The unmarked bio-sensing fibre system of multichannel - Google Patents
The unmarked bio-sensing fibre system of multichannel Download PDFInfo
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- CN104458587B CN104458587B CN201410766162.6A CN201410766162A CN104458587B CN 104458587 B CN104458587 B CN 104458587B CN 201410766162 A CN201410766162 A CN 201410766162A CN 104458587 B CN104458587 B CN 104458587B
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Abstract
The present invention provides a kind of unmarked bio-sensing fibre system of multichannel, including：The light source of coupled into optical fibres, the light wave that optical fiber is transmitted is coupled and/or oriented the optical fiber circuit of transmission, the photoswitch of optical fiber input and output, optical fiber and optical detection part with reflective unmarked optical sensor on many butts, wherein, the photoswitch of the optical fiber input and output has multiple-channel output and/or multichannel input, and the reflected light of the reflective unmarked optical sensor for the optical fiber end for making to specify in the multiple-channel output and/or multichannel input by switch is received by optical detection part, realizes that multichannel is sensed.The invention provides a kind of unmarked bio-sensing fibre system of multi-channel parallel detected to multiple biological samples, because having merged the means such as the optical fiber circuit in Fibre Optical Communication Technology, photoswitch, this system can be only comprising an optical detection part, greatly reduce system complexity and reduce system bulk, and with the good stability of a system.
Description
Technical field
The invention belongs to bio-sensing and Instrument Design field, more particularly to a kind of unmarked bio-sensing light of multichannel
Fine system.
Background technology
To the quantitative measurment of bio-molecular interaction in life science basic research, new medicament screen and exploitation and food
Industry is used widely.Traditional detection and analysis uses Enzyme-linked Immunosorbent Assay technology, and is not required to fluorescence labeling in recent years
Unmarked optical bio sensing technology is developed rapidly.The advantage of unmarked sensing technology is the natural spy for keeping sample
Levy, and be greatly saved the time and labor of operating personnel；Importantly, unmarked sensing technology is moved to interaction of molecules
Mechanical process is measured in real time, there is important value in terms of scientific research and drug screening.
In the unmarked optical bio sensor-based system based on free-space optical transmission, to realize to multiple samples or anti-
The parallel detection (multichannel sensing) of process is answered, multiple optical detection parts is often needed to use, increases system bulk and cost.With
Optical fiber as optical transport medium, the treatment technology of optical signal will be incorporated into biological sensing system in fiber optic communication can make be
System performance is significantly improved.But the unmarked bio-sensing fibre system having been reported lacks to the good of Fibre Optical Communication Technology
Compatibility, it is either free empty using the transmission detection framework for being difficult to operation or still partial dependency when realizing multichannel sensing
Between optical transport.
The content of the invention
The shortcoming of prior art, is passed it is an object of the invention to provide a kind of unmarked biology of multichannel in view of the above
Fibre system is felt, to realize a kind of unmarked sensing element of the optical fiber end using optical fiber circuit, reflective and photoswitch as core group
Into part, the system that biochemical samples are carried out with multi-channel parallel sensing.
In order to achieve the above objects and other related objects, the present invention provides a kind of unmarked bio-sensing optical fiber system of multichannel
System, including：The light source of coupled into optical fibres, the light wave to optical fiber transmission are coupled and/or oriented the optical fiber circuit of transmission, optical fiber
There is the optical fiber and optical detection part of reflective unmarked optical sensor on the photoswitch of input-output, many butts,
Wherein, the reflective unmarked optical sensor is incorporated on the end of optical fiber, rather than discrete with optical fiber, described reflective
The optical fiber guided wave being radiated at from light source and after optical fiber circuit thereon is reflected back where it by unmarked optical sensor
Same optical fiber, reflected light receives and measured by optical detection part after optical fiber circuit, the light of the optical fiber input-output
Switch is inputted with multiple-channel output and/or multichannel, and makes the optical fiber that the multiple-channel output and/or multichannel are specified in inputting by switch
The reflected light of the reflective unmarked optical sensor at end is received by optical detection part, realizes that multichannel is sensed.
Reflective unmarked optical sensor is immersed in testing sample during measurement, reflective unmarked optical sensing
The optical fiber guided wave being radiated at from light source and after optical fiber circuit thereon is reflected back into same optical fiber where it by element,
Reflected light is received and measured by optical detection part after optical fiber circuit, and measurement result reflects the information of detected sample.Wherein,
Operating the photoswitch of the optical fiber input-output can cause not in the same time from different reflective unmarked optical sensing members
The reflected light of part is received by optical detection part, realizes that multichannel is sensed.
It is used as a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the optical fiber circuit bag
Directional couple device is included, for the light wave that optical fiber is transmitted being coupled and being oriented transmission.
It is used as a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the directional couple dress
Put one kind or combination including directional coupler and optical circulator.
Further, the directional coupler is that splitting ratio is 50%：50% 2 × 2 directional couplers.
It is used as a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the directional couple dress
The first port put is connected to light source, the input with first port of the directional couple device directly connected in light path
Two-port netwerk is connected with the input port of optical fiber input-output photoswitch, and there is reflective unmarked optics to pass on many butts
The optical fiber of sensing unit is connected to each road output port of the optical fiber input-output photoswitch, the directional couple device with
The 3rd port that the input of second port is directly connected in light path is connected to optical detection part.
As a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the optical fiber circuit is also
Including beam splitter, for being split transmission to the light wave that optical fiber is transmitted.
Further, the input port of the beam splitter is connected to light source, each road beam splitting output port of the beam splitter
It is connected with the first port of the directional couple device, there is the light of reflective unmarked optical sensor on many butts
Fibre is connected to the second port that the input with first port of each directional couple device is directly connected in light path, and the optical fiber is defeated
Enter-export the multi-channel input mouth of photoswitch respectively with the input with second port of the directional couple device in light path it is straight
The 3rd logical port connection in succession, the output port of the optical fiber input-output photoswitch is connected with the optical detection part.
As a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the optical fiber circuit is also
Including bundling device, the light wave for being transmitted to multi-channel optical fibre carries out closing beam transmission.
Further, the input port of the optical fiber input-output photoswitch is connected with light source, the optical fiber input-defeated
Go out first port of the multiple-channel output port of photoswitch respectively with the directional couple device to be connected, have on many butts anti-
Penetrating the optical fiber of the unmarked optical sensor of formula, to be connected to the input with first port of each directional couple device straight in light path
The second port led in succession, the multi-channel input mouthful of the bundling device is connected to the defeated with second port of each directional couple device
Enter the 3rd port directly connected in light path, the output port of the bundling device is connected to the optical detection part.
It is including more than two as a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention
The photoswitch and/or more than two optical detection parts and/or two of light source and/or more than two optical fiber input-outputs
Directional couple device above, and/or more than two beam splitters and/or more than two bundling devices.
As a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the light source includes halogen
Plain lamp, light emitting diodes, super-radiance light emitting diode, super continuum source, the one of amplified spontaneous emission source and laser
Plant or combine.
It is used as a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the optical detection part
One kind or combination including spectrometer and optical power detector.
It is described reflective without mark as a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention
Note optical sensor is made in fiber end face and/or is bonded in fiber end face.
Further, the reflective unmarked optical sensor is is made in fiber end face and/or is bonded in optical fiber
The golden film with nanometer groove array of end face.
As a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the multichannel is without mark
Remember the optical fiber in bio-sensing fibre system to correspond to the single-mode fiber or polarization maintaining optical fibre or single-mode fiber that it transmits light wave
With the combination of polarization maintaining optical fibre.
As a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the multichannel is without mark
Optical fiber in note bio-sensing fibre system is correspondingly its multimode fibre or single-mode fiber for transmitting light wave and multimode fibre
Combination or combination or single-mode fiber, the combination of polarization maintaining optical fibre and multimode fibre of polarization maintaining optical fibre and multimode fibre.
Further, the diameter range of the guided wave fibre core of the multimode fibre is 1 μm of -10mm.
Further, the diameter range of the guided wave fibre core of the multimode fibre is 1 μm -200 μm.
Further, the diameter range of the guided wave fibre core of the multimode fibre is 1 μm -100 μm.
As a kind of preferred scheme of the unmarked bio-sensing fibre system of multichannel of the present invention, the multichannel is without mark
The detected sample for remembering bio-sensing fibre system is to include the energy of biomolecule and/or chemical molecular and/or metal ion
Cause light refractive index and/or the material of change in optical path length.
Further, detected sample be the solution containing testing molecule, when testing molecule be attached to it is reflective unmarked
When on optical sensor, the spectrum and/or intensity of reflected light change and are measured to.
As described above, the present invention provides a kind of unmarked bio-sensing fibre system of multichannel, including：Coupled into optical fibres
Light source, coupled and/or oriented the optical fiber circuit of transmission to the light wave that optical fiber is transmitted, it is the photoswitch of optical fiber input-output, many
There is the optical fiber and optical detection part of reflective unmarked optical sensor on butt, wherein, it is described reflective unmarked
Optical sensor is incorporated on the end of optical fiber, rather than discrete with optical fiber, and the reflective unmarked optical sensor will
The optical fiber guided wave being radiated at from light source and after optical fiber circuit thereon is reflected back same optical fiber where it, reflected light warp
Cross after optical fiber circuit and to be received and be measured by optical detection part, the photoswitch of the optical fiber input-output have multiple-channel output and/or
Multichannel is inputted, and the reflective unmarked optics for the optical fiber end for making to specify in the multiple-channel output and/or multichannel input by switch
The reflected light of sensing element is received by optical detection part, realizes that multichannel is sensed.The invention provides one kind to multiple biological samples
The unmarked bio-sensing fibre system for the multi-channel parallel that product are detected, because having merged the optical fiber in Fibre Optical Communication Technology
The means such as loop, photoswitch, this system can greatly reduce system complexity and reduce only comprising an optical detection part
System bulk, and with the good stability of a system.
Brief description of the drawings
Fig. 1 is shown as the structural representation of the unmarked bio-sensing fibre system of multichannel of the embodiment of the present invention 1.
Fig. 2 is shown as the structural representation of the unmarked bio-sensing fibre system of multichannel of the embodiment of the present invention 2.
Fig. 3 is shown as the structural representation of the unmarked bio-sensing fibre system of multichannel of the embodiment of the present invention 3.
Fig. 4 is shown as the structural representation of the unmarked bio-sensing fibre system of multichannel of the embodiment of the present invention 4.
Fig. 5 is shown as the reflective unmarked optical sensing in the unmarked bio-sensing fibre system of multichannel of the present invention
The structural representation of element.
Optical wavelength-reflectivity that Fig. 6 is shown as the unmarked bio-sensing fibre system of multichannel of the embodiment of the present invention 1 is real
Test curve synoptic diagram.
Component label instructions
10 light sources
11 directional couple devices
The photoswitch of 12 optical fiber input-outputs
There is the optical fiber of reflective unmarked optical sensor on 13 ends
131 reflective unmarked optical sensors
14 optical detection parts
15 beam splitters
16 bundling devices
17 testing samples
Embodiment
Illustrate embodiments of the present invention below by way of specific instantiation, those skilled in the art can be by this specification
Disclosed content understands other advantages and effect of the present invention easily.The present invention can also pass through specific realities different in addition
The mode of applying is embodied or practiced, the various details in this specification can also based on different viewpoints with application, without departing from
Various modifications or alterations are carried out under the spirit of the present invention.
Refer to Fig. 1~Fig. 6.It should be noted that the diagram provided in the present embodiment only illustrates this in a schematic way
The basic conception of invention, then in schema only display with relevant component in the present invention rather than according to package count during actual implement
Mesh, shape and size are drawn, and kenel, quantity and the ratio of each component can be a kind of random change during its actual implementation, and its
Assembly layout kenel may also be increasingly complex.
Embodiment 1
As shown in Figures 1 and 5, the present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, including：Coupling
Enter the light source 10 of optical fiber, the light wave that optical fiber is transmitted coupled and oriented the optical fiber circuit of transmission, the light of optical fiber input-output
There is the optical fiber 13 and optical detection part 14 of reflective unmarked optical sensor 131 on switch 12, many butts, wherein,
The reflective unmarked optical sensor 131 is incorporated on the end of optical fiber 13, rather than discrete with optical fiber, described reflective
The optical fiber guided wave being radiated at from light source 10 and after optical fiber circuit thereon is reflected back it by unmarked optical sensor 131
The same optical fiber at place, reflected light is received and measured by optical detection part 14 after optical fiber circuit, the optical fiber input-defeated
The photoswitch 12 gone out has multiple-channel output, and the reflective unmarked light for the optical fiber end for making to specify in the multiple-channel output by switch
The reflected light for learning sensing element 131 is received by optical detection part 14, realizes that multichannel is sensed.
Reflective unmarked optical sensor 131 is immersed in testing sample 17 during measurement, reflective unmarked light
Learn sensing element 131 the optical fiber guided wave being radiated at from light source 10 and after optical fiber circuit thereon is reflected back into where it
Same optical fiber, reflected light is received and measured by optical detection part 14 after optical fiber circuit, and measurement result reflects test sample to be checked
The information of product 17.Wherein, the photoswitch 12 of the optical fiber input-output is operated do not coming from different reflections in the same time
The reflected light of the unmarked optical sensor 131 of formula is received by optical detection part 14, realizes that multichannel is sensed.
In the present embodiment, the optical fiber in the unmarked bio-sensing fibre system of the multichannel is its transmission light of correspondence
The single-mode fiber of ripple.The compatibility of system and optical communication technique can be improved using single-mode fiber.
As shown in figure 1, the optical fiber circuit includes directional couple device 11, for being coupled to the light wave that optical fiber is transmitted
And orientation transmission, in the present embodiment, the directional couple device 11 is that splitting ratio is 50%：50% 2 × 2 directional couples
Device.The first port of 2 × 2 directional coupler is connected to the light source 10, and the input with first port is direct in light path
The second port of connection is connected with the input port of the optical fiber input-output photoswitch 12, has reflection on many butts
The optical fiber 13 of the unmarked optical sensor 131 of formula is connected to each road output port of the optical fiber input-output photoswitch 12.
The 3rd port directly connected in light path with second port input of 2 × 2 directional coupler is connected to the optical detection
Part 14.
As shown in figure 5, the reflective unmarked optical sensor 131 is bonded in fiber end face, the reflective nothing
Mark optical sensor is the golden film with nanometer groove array, and described golden film thickness 25nm, nanometer groove runs through whole golden film
Thickness, the nanometer groove cycle be 635nm, nanometer well width be 50nm.Certainly, the reflective unmarked optical sensor
131 both can be bonded in fiber end face as the present embodiment by way of bonding after completing, can also pass through electricity
The methods such as beamlet photoetching, focused-ion-beam lithography are directly produced on fiber end face, in addition, other manner realization is reflective without mark
Note optical sensor is applied equally to the present invention, however it is not limited to example recited herein.
As shown in figure 1, specifically, wide spectrum light source (such as Halogen lamp LED, light emitting diodes, super-radiance light emitting diode, super company
Continuous spectrum light source or amplified spontaneous emission source) single-mode fiber is coupled into, then light wave enters single-mode fiber input-output
The first port of 2 × 2 directional couplers, is divided into two-way.Wherein directional couple is output to the second end of directional coupler all the way
Mouthful, then be transferred into through optical fiber single-mode fiber input-output 1 × N photoswitches (such as 1 × 8 mechanical optical switch) it is defeated
Inbound port, that is, that end for having 1 optical fiber, then the output that light wave specifies from N number of output port is allowed by switching manipulation.So
Light wave enters on a butt optical fiber 13 with reflective unmarked optical sensor 131 after being transmitted by optical fiber, then instead
Penetrate the same optical fiber that this incident optical fiber guided wave is reflected back into where it by the unmarked optical sensor 131 of formula.It is reflective
Unmarked optical sensor 131 is immersed in testing sample 17, with the combination, dissociation, concentration of material to be detected in sample
Change etc. behavior, the spectrum and intensity respective change of reflected light.Reflected light is transmitted through optical fiber inversely enters 1 × N photoswitches
Same appointed output terminal mouthful simultaneously comes out from its input port.Then light wave inputs the second port of 2 × 2 directional couplers, then
It is divided into two-way, wherein directional couple is output to the 3rd port of directional coupler all the way.Last light wave is transmitted by light through optical fiber
Exploring block 14 is received and measured.In the present embodiment, the optical detection part 14 is spectrometer (such as grating spectrograph).Spectrum
Instrument is measured to reflectance spectrum, and the situation of testing sample 17 is inferred with this.In such a system, operating optical switches make it in difference
Time specify one of different N number of output ports, can cause from different reflective unmarked optical sensors 131
Reflected light received in the different time by optical detection part 14, to realize to the multi-channel parallel of N number of sample sensing.
Certainly, in such scheme, the light source can also use the laser of Single wavelength, and corresponding optical detection part 14 is surveyed
What is measured is the power of reflected light, such as optical detection part 14 is optical power detector, and it includes a photodiode.
In addition, it is necessary to explanation, first, testing sample 17 can be liquid, gas.Second, material to be detected can be with
It is that biomolecule, chemical molecular, metal ion etc. cause light refractive index, the material of change in optical path length.More specifically, test sample is treated
Product are the solution containing certain testing molecule.When this molecule is attached on reflective unmarked optical sensor, reflection
The spectrum or intensity of light change and are measured to.3rd, the position of testing sample can be in microfluid, porous plate or other
In Common containers.
Embodiment 2
As shown in Fig. 2 the present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, including：Couple entering light
The light source 10 of fibre, the light wave to optical fiber transmission are coupled and oriented the optical fiber circuit of transmission, the photoswitch of optical fiber input-output
12nd, there is the optical fiber 13 and optical detection part 14 of reflective unmarked optical sensor 131 on many butts, wherein, it is described
Reflective unmarked optical sensor 131 is incorporated on the end of optical fiber 13, rather than discrete with optical fiber, described reflective without mark
The optical fiber guided wave being radiated at from light source 10 and after optical fiber circuit thereon is reflected back where it by note optical sensor 131
Same optical fiber, reflected light receives and measured by optical detection part 14 after optical fiber circuit, the optical fiber input-output
Photoswitch 12 is inputted with multichannel, and the reflective unmarked optics for the optical fiber end for making to specify in multichannel input by switch is passed
The reflected light of sensing unit 131 is received by optical detection part 14, realizes that multichannel is sensed.
Reflective unmarked optical sensor 131 is immersed in testing sample 17 during measurement, reflective unmarked light
Learn sensing element 131 the optical fiber guided wave being radiated at from light source 10 and after optical fiber circuit thereon is reflected back into where it
Same optical fiber, reflected light is received and measured by optical detection part 14 after optical fiber circuit, and measurement result reflects test sample to be checked
The information of product 17.Wherein, the photoswitch 12 of the optical fiber input-output is operated do not coming from different reflections in the same time
The reflected light of the unmarked optical sensor 131 of formula is received by optical detection part 14, realizes that multichannel is sensed.
In the present embodiment, the optical fiber in the unmarked bio-sensing fibre system of the multichannel is its transmission light of correspondence
The single-mode fiber of ripple.The compatibility of system and optical communication technique can be improved using single-mode fiber.
As shown in Fig. 2 the optical fiber circuit includes directional couple device 11, for being coupled to the light wave that optical fiber is transmitted
And orientation transmission, in the present embodiment, the directional couple device 11 is that splitting ratio is 50%：50% 2 × 2 directional couples
Device.The optical fiber circuit also includes beam splitter 15, for being split transmission to the light wave that optical fiber is transmitted.The beam splitter it is defeated
Inbound port is connected to light source, and each road beam splitting output port is connected with the first port of 2 × 2 directional coupler, and described 2 × 2
The second port that the input with first port of directional coupler is directly connected in light path is with having reflection on many butts
The optical fiber 13 of the unmarked optical sensor 131 of formula is connected.The multi-channel input mouthful point of the optical fiber input-output photoswitch 12
Do not input the 3rd port directly connected in light path with 2 × 2 directional coupler and second port to be connected, the optical fiber
The output port of input-output photoswitch 12 is connected to optical detection part 14.
As shown in Fig. 2 being first N by 15 points of a beam splitter after the light wave coupled into optical fibres from light source specifically
Road.N roads light wave each respectively enters the first port of 2 × 2 directional couplers, is divided into two-way.Coupling is wherein oriented all the way
The second port for being output to directional coupler is closed, then entering through light transmission fiber ripple has reflective unmarked light on a butt
The optical fiber 13 of sensing element 131 is learned, then this incident optical fiber guided wave is reflected back by reflective unmarked optical sensor 131
Same optical fiber where to it.Then light wave inputs the second port of 2 × 2 directional couplers, then is divided into two-way, wherein one
Road directional couple is output to the 3rd port of directional coupler.Light wave is transferred into the input of the photoswitch of N × 1 through optical fiber again
Mouthful, that is, there is that end of N root optical fiber, then the light wave of one specified is allowed in N number of input port by switching manipulation from its output end
Mouth comes out.Last light wave is received and measured by optical detection part 14 through optical fiber transmission.In such a system, operating optical switches make its
The different time specifies one of different N number of input ports, can cause from different reflective unmarked optical sensing members
The reflected light of part 131 is received in the different time by optical detection part 14, to realize the multi-channel parallel sensing to N number of sample.
Embodiment 3
As shown in figure 3, the present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, including：Couple entering light
The light source 10 of fibre, the light wave to optical fiber transmission are coupled and oriented the optical fiber circuit of transmission, the photoswitch of optical fiber input-output
12nd, there is the optical fiber 13 and optical detection part 14 of reflective unmarked optical sensor 131 on many butts, wherein, it is described
Reflective unmarked optical sensor 131 is incorporated on the end of optical fiber 13, rather than discrete with optical fiber, described reflective without mark
The optical fiber guided wave being radiated at from light source 10 and after optical fiber circuit thereon is reflected back where it by note optical sensor 131
Same optical fiber, reflected light receives and measured by optical detection part 14 after optical fiber circuit, the optical fiber input-output
Photoswitch 12 has multiple-channel output, and the reflective unmarked optics for the optical fiber end for making to specify in the multiple-channel output by switch is passed
The reflected light of sensing unit 131 is received by optical detection part 14, realizes that multichannel is sensed.
Reflective unmarked optical sensor 131 is immersed in testing sample 17 during measurement, reflective unmarked light
Learn sensing element 131 the optical fiber guided wave being radiated at from light source 10 and after optical fiber circuit thereon is reflected back into where it
Same optical fiber, reflected light is received and measured by optical detection part 14 after optical fiber circuit, and measurement result reflects test sample to be checked
The information of product 17.Wherein, the photoswitch 12 of the optical fiber input-output is operated do not coming from different reflections in the same time
The reflected light of the unmarked optical sensor 131 of formula is received by optical detection part 14, realizes that multichannel is sensed.
In the present embodiment, the optical fiber in the unmarked bio-sensing fibre system of the multichannel is its transmission light of correspondence
The single-mode fiber of ripple.The compatibility of system and optical communication technique can be improved using single-mode fiber.
As shown in figure 3, the optical fiber circuit includes directional couple device 11, for being coupled to the light wave that optical fiber is transmitted
And orientation transmission, in the present embodiment, the directional couple device 11 is that splitting ratio is 50%：50% 2 × 2 directional couples
Device.The optical fiber circuit also includes bundling device 16, and the light wave for being transmitted to multi-channel optical fibre carries out closing beam transmission.The optical fiber is defeated
The input port for entering-exporting photoswitch 12 is connected with light source, its multiple-channel output port respectively with 2 × 2 directional coupler
First port is connected, the second port that the input with first port of 2 × 2 directional coupler is directly connected in light path with
The optical fiber 13 with reflective unmarked optical sensor 131 is connected on many butts.The multichannel input of the bundling device
Port inputs the 3rd port directly connected in light path with 2 × 2 directional coupler and second port respectively and is connected, institute
The output port for stating bundling device is connected to optical detection part 14.
As shown in figure 3, specifically, after the light wave coupled into optical fibres from light source, into 1 × N of optical fiber input-output
The input port of photoswitch, and by optical fiber input-output 1 × N photoswitches specify be output to one of N number of output port.Then
Light wave enters the first port of 2 × 2 directional couplers, is divided into two-way.Wherein directional couple is output to orientation coupling all the way
The second port of clutch, light wave, which enters, after then being transmitted through optical fiber has reflective unmarked optical sensor on a butt
131 optical fiber 13, then reflective unmarked optical sensor 131 this incident optical fiber guided wave is reflected back into where it
Same optical fiber.Then light wave enters the second port of 2 × 2 directional couplers, then is divided into two-way, wherein directional couple all the way
It is output to the 3rd port of directional coupler.Light wave is transferred into the multi-channel input mouthful of bundling device 16 through optical fiber again, that is, has many
That end of root optical fiber, and exported from the output port of bundling device 16.Last light wave is received through optical fiber transmission by optical detection part 14
And measure.In such a system, operating optical switches make it specify one of different N number of output ports in the different time, can make
It must be connect from the reflected light of different reflective unmarked optical sensors 131 in the different time by optical detection part 14
Receive, to realize the multi-channel parallel sensing to N number of sample.
Embodiment 4
The present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, its basic structure such as embodiment 1, implementation
Example 2 and/or embodiment 3, wherein, by combining the light source 10 of coupled into optical fibres, the light wave that optical fiber is transmitted being coupled and determined
There is reflective unmarked optical sensor on to the optical fiber circuit of transmission, the photoswitch 12 of optical fiber input-output, many butts
131 optical fiber 13 and optical detection part 14, realizes more complicated fibre system, for example, using more than two coupling entering lights
Fine light source 10 and/or two or more optical detection part 14 and/or more than two beam splitters 15 and/or more than two
Bundling device 16, can obtain more massive parallel sensor-based system, in another example, using the photoswitch of multiple optical fiber input-outputs
12, or input by directional couple device 11 and/or the photoswitch of optical fiber input-output 12 and/or output port number
Change, the parallel sensor-based system of different system framework can be obtained.
Specifically, as shown in figure 4, the present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, it includes
The light source 10 of two coupled into optical fibres, the photoswitch 12 of two optical fiber input-outputs, beam splitter 15, a multiple directional couples
There is the optical fiber 13 and two optical detection parts 14 of reflective unmarked optical sensor 131 on device 11, many butts, it is above-mentioned
The annexation of element can clearly be drawn according to embodiment 1 and embodiment 2 and Fig. 4 description, no longer be listed one by one herein.
Wherein, the photoswitch 12 of two described optical fiber input-outputs is respectively 1 × N photoswitches and one of an optical fiber input-output
The photoswitch of the M of individual optical fiber input-output × 2, wherein, two output ends of the photoswitch of the M of optical fiber input-output × 2 connect respectively
It is connected to an optical detection part.
Embodiment 5
The present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, its basic structure such as embodiment 1, implementation
Example 2, embodiment 3 and/or embodiment 4, wherein, 2 × 2 in embodiment 1, embodiment 2, embodiment 3 and/or embodiment 4 are determined
3 multi-port optical circulators are replaced with to coupler.In optical circulator, the light of first (two, three) port input is from second
(three, one) port is exported.The annexation of first, second and third port of optical circulator respectively correspond to embodiment 1, embodiment 2,
The annexation of first, second and third port of 2 × 2 directional couplers in embodiment 3 and embodiment 4.
Correspondence embodiment 1, first, second and third port of the 3 multi-port optical circulator corresponds to 2 × 2 directional couplers respectively
Connection light source 10 port, connect single-mode fiber input-output photoswitch 12 port and connection optical detection part 14
Port.
Correspondence embodiment 2, first, second and third port of the 3 multi-port optical circulator corresponds to 2 × 2 directional couplers respectively
The port of connection beam splitter 15, have on many butts of connection reflective unmarked optical sensor 131 optical fiber 13 end
The port of mouth and the photoswitch 12 of connection single-mode fiber input-output.
Correspondence embodiment 3, first, second and third port of the 3 multi-port optical circulator corresponds to 2 × 2 directional couplers respectively
Connection single-mode fiber input-output photoswitch 12 port, connect there is reflective unmarked optical sensing on many butts
The port of the optical fiber 13 of element 131 and the port of connection bundling device 16.
Embodiment 6
The present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, its basic structure such as embodiment 1, implementation
Example 2, embodiment 3, embodiment 4 and/or embodiment 5, wherein, the optical fiber in the unmarked bio-sensing fibre system of multichannel
Replace with polarization maintaining optical fibre or single-mode fiber and the combination of polarization maintaining optical fibre for corresponding to that it transmits light wave.
Embodiment 7
The present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, its basic structure such as embodiment 1, implementation
Example 2, embodiment 3, embodiment 4 and/or embodiment 5, wherein, the optical fiber in the unmarked bio-sensing fibre system of multichannel
Replace with multimode fibre or single-mode fiber and the combination of multimode fibre or polarization maintaining optical fibre and the multimode for corresponding to that it transmits light wave
Combination or single-mode fiber, the combination of polarization maintaining optical fibre and multimode fibre of optical fiber.Wherein, the guided wave fibre core of the multimode fibre
Diameter range is 1 μm of -10mm.In a specific implementation process, the diameter range of the guided wave fibre core of the multimode fibre is 1
μm-200μm.In a specific implementation process, the diameter range of the guided wave fibre core of the multimode fibre is 1 μm -100 μm.
Although being unfavorable for merging the optical communication technique based on single-mode fiber or polarization maintaining optical fibre, but still energy using multimode fibre
Access the beneficial effect such as small volume, simple to operate, multi-channel parallel sensing.
Embodiment 8
The present embodiment provides a kind of unmarked bio-sensing fibre system of multichannel, its basic structure such as embodiment 1, implementation
Example 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6 and/or embodiment 7, wherein, with the above-mentioned unmarked biology of multichannel
Based on sensor fibre system, other technologies and component are added, for example：1) reference channel is added, to correct light source, optical transport
And/or change of the reflective unmarked optical sensor under the influence of temperature, stress etc. factor over time.With reference to logical
Road is optical signal of the detection as reference, such as the reflective unmarked optical sensor in optical fiber end is placed in into air or slow
In the single medium such as fliud flushing, its reflected signal is measured as reference, can be specified and is incident in some moment light by photoswitch
The sensing element of reference channel and its reflected light be detected part and receive, and can not also be specified by photoswitch and reference channel
The reflected light of reflective unmarked optical sensor is directly detected part and received.The sensing of fiber end face in reference channel
Element can be that gold nano slot structure or one layer do not have structured golden film.Reference channel can not also include reflective
Unmarked optical sensor, such as be directly connected to optical detection part by the light of light source through optical fiber circuit.2) to optical fiber guided wave
Polarization apply control and/or change.3) wavelength-division multiplex and/or de-multiplexing technique are used to optical fiber guided wave.
Embodiment 9
As shown in fig. 6, the present embodiment is tested to the unmarked bio-sensing fibre system of multichannel of embodiment 1
(optical wavelength-reflectivity experiment).In the present embodiment, 1 × 8 photoswitch of single-mode fiber input-output is switched to every 50ms
Next output port, spectrometer records the reflectance spectrum of each passage with the 40ms time of integration.8 end faces have reflective without mark
The single-mode fiber 13 of note optical sensor 131 is respectively placed in the container for the salt solution for filling 8 kinds of various concentrations, and respectively 3%
Saline solution, 7% saline solution, 10% saline solution, 12% saline solution, 16% saline solution, 19% saline solution, 21%
Saline solution, 24% saline solution.Last our parallel various concentrations and light for obtaining 8 reflectance spectrums, reflecting 8 samples
Learn refractive index.As can be seen that the present invention the unmarked bio-sensing fibre system of multichannel both can with the multiple samples of parallel measurement,
There is preferable stability again.Wherein, in this experiment, light source, 50% are used as using wide range bromine tungsten halogen lamp：50% splitting ratio
2 × 2 directional couplers, 1 × 8 mechanical optical switch, microgratings spectrometer is used as optical detection part.Optical fiber is using correspondence
The single-mode fiber of 780nm wavelength, optical fiber interface is FC/APC forms.Reflective unmarked sensing element is the nanometer groove in golden film
Array, golden film thickness 25nm, nanometer groove runs through whole golden film, nanometer groove cycle 635nm, nanometer well width 50nm.
As described above, the present invention provides a kind of unmarked bio-sensing fibre system of multichannel, including：Coupled into optical fibres
Light source, coupled and/or oriented the optical fiber circuit of transmission to the light wave that optical fiber is transmitted, it is the photoswitch of optical fiber input-output, many
There is the optical fiber and optical detection part of reflective unmarked optical sensor on butt, wherein, it is described reflective unmarked
Optical sensor is incorporated on the end of optical fiber, rather than discrete with optical fiber, and the reflective unmarked optical sensor will
The optical fiber guided wave being radiated at from light source and after optical fiber circuit thereon is reflected back same optical fiber where it, reflected light warp
Cross after optical fiber circuit and to be received and be measured by optical detection part, the photoswitch of the optical fiber input-output have multiple-channel output and/or
Multichannel is inputted, and the reflective unmarked optics for the optical fiber end for making to specify in the multiple-channel output and/or multichannel input by switch
The reflected light of sensing element is received by optical detection part, realizes that multichannel is sensed.The invention provides one kind to multiple biological samples
The unmarked bio-sensing fibre system for the multi-channel parallel that product are detected, because having merged the optical fiber in Fibre Optical Communication Technology
The means such as loop, photoswitch, this system can greatly reduce system complexity and reduce only comprising an optical detection part
System bulk, and with the good stability of a system.So, the present invention effectively overcomes various shortcoming of the prior art and had
High industrial utilization.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (16)
1. a kind of unmarked bio-sensing fibre system of multichannel, it is characterised in that including：
The light source of coupled into optical fibres, to be coupled and/or oriented the optical fiber circuit of transmission, optical fiber defeated for the light wave transmitted to optical fiber
There is the optical fiber and optical detection part of reflective unmarked optical sensor on the photoswitch that enters-export, many butts,
Wherein, for correspondence, it transmits the single-mode optics of light wave to the optical fiber in the unmarked bio-sensing fibre system of the multichannel
Fibre, the reflective unmarked optical sensor is incorporated on the end of optical fiber, rather than discrete with optical fiber, the reflective nothing
The optical fiber guided wave being radiated at from light source and after optical fiber circuit thereon is reflected back where it by mark optical sensor
Same optical fiber, reflected light is received and measured by optical detection part after optical fiber circuit, and the light of the optical fiber input-output is opened
Close and inputted with multiple-channel output and/or multichannel, and the optical fiber end that the multiple-channel output and/or multichannel are specified in inputting is made by switch
The reflected light of reflective unmarked optical sensor received in different time by optical detection part, realize that multichannel is sensed.
2. the unmarked bio-sensing fibre system of multichannel according to claim 1, it is characterised in that：The optical fiber circuit
Including directional couple device, for the light wave that optical fiber is transmitted being coupled and being oriented transmission.
3. the unmarked bio-sensing fibre system of multichannel according to claim 2, it is characterised in that：The directional couple
Device includes one kind or the combination of directional coupler and optical circulator.
4. the unmarked bio-sensing fibre system of multichannel according to claim 3, it is characterised in that：The directional couple
Device is that splitting ratio is 50%：50% 2 × 2 directional couplers.
5. the unmarked bio-sensing fibre system of multichannel according to claim 2, it is characterised in that：The directional couple
The first port of device is connected to light source, what the input with first port of the directional couple device was directly connected in light path
Second port is connected with the input port of optical fiber input-output photoswitch, has reflective unmarked optics on many butts
The optical fiber of sensing element is connected to each road output port of the optical fiber input-output photoswitch, the directional couple device
Optical detection part is connected to the 3rd port that the input of second port is directly connected in light path.
6. the unmarked bio-sensing fibre system of multichannel according to claim 2, it is characterised in that：The optical fiber circuit
Also include beam splitter, for being split transmission to the light wave that optical fiber is transmitted.
7. the unmarked bio-sensing fibre system of multichannel according to claim 6, it is characterised in that：The beam splitter
Input port is connected to light source, and each road beam splitting output port of the beam splitter connects with the first port of the directional couple device
Connect, on many butts the optical fiber with reflective unmarked optical sensor be connected to each directional couple device with first
The second port that the input of port is directly connected in light path, the multi-channel input mouthful point of the optical fiber input-output photoswitch
The 3rd port not connected directly in light path with the input with second port of the directional couple device is connected, the optical fiber
The output port of input-output photoswitch is connected with the optical detection part.
8. the unmarked bio-sensing fibre system of multichannel according to claim 2, it is characterised in that：The optical fiber circuit
Also include bundling device, the light wave for being transmitted to multi-channel optical fibre carries out closing beam transmission.
9. the unmarked bio-sensing fibre system of multichannel according to claim 8, it is characterised in that：The optical fiber is defeated
The input port for entering-exporting photoswitch is connected with light source, the multiple-channel output port of the optical fiber input-output photoswitch respectively with
There is the optical fiber of reflective unmarked optical sensor on the first port connection of the directional couple device, many butts
The second port that the input with first port of each directional couple device is directly connected in light path is connected to, the bundling device
Multi-channel input mouthful is connected to the 3rd port that the input with second port of each directional couple device is directly connected in light path,
The output port of the bundling device is connected to the optical detection part.
10. the unmarked bio-sensing fibre system of multichannel according to claim 1, it is characterised in that：Including two with
On coupled into optical fibres light source and/or the photoswitch of more than two optical fiber input-outputs and/or more than two light visit
Survey part and/or more than two directional couple devices, and/or more than two beam splitters and/or more than two conjunction beams
Device.
11. the unmarked bio-sensing fibre system of multichannel according to claim 1~10 any one, its feature exists
In：The light source includes Halogen lamp LED, light emitting diodes, super-radiance light emitting diode, super continuum source, amplified spontaneous emission
One kind or combination of light source and laser.
12. the unmarked bio-sensing fibre system of multichannel according to claim 1~10 any one, its feature exists
In：The optical detection part includes one kind or the combination of spectrometer and optical power detector.
13. the unmarked bio-sensing fibre system of multichannel according to claim 1~10 any one, its feature exists
In：The reflective unmarked optical sensor is made in fiber end face and/or is bonded in fiber end face.
14. the unmarked bio-sensing fibre system of multichannel according to claim 13, it is characterised in that：It is described reflective
Unmarked optical sensor is the golden film with nanometer groove array for being made in fiber end face and/or being bonded in fiber end face.
15. the unmarked bio-sensing fibre system of multichannel according to claim 1~10 any one, its feature exists
In：The detected sample of the unmarked bio-sensing fibre system of multichannel be include biomolecule and/or chemical molecular,
And/or metal ion can cause light refractive index and/or the material of change in optical path length.
16. the unmarked bio-sensing fibre system of multichannel according to claim 15, it is characterised in that：Detected sample
For the solution containing testing molecule, when testing molecule is attached on reflective unmarked optical sensor, the light of reflected light
Spectrum and/or intensity change and are measured to.
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| CN107621274B (en) * | 2016-07-13 | 2020-01-07 | 上海交通大学 | A kind of optical fiber sensor and its acoustic wave detection application method |
| CN108169193A (en) * | 2017-12-11 | 2018-06-15 | 华侨大学 | A kind of portable Multi-example detection fiber biosensor |
| US20210341472A1 (en) * | 2018-05-09 | 2021-11-04 | Shanghai Jiao Tong University | Solid-phase surface and solution motion mode and motion device |
| CN112198124A (en) * | 2019-11-15 | 2021-01-08 | 北京微芯区块链与边缘计算研究院 | Optical probe of optical fiber type full spectrum water quality sensor |
| CN113029947A (en) * | 2019-12-25 | 2021-06-25 | 中国科学院长春光学精密机械与物理研究所 | Optical fiber sensing system for biomarkers |
| CN113155782A (en) * | 2021-04-27 | 2021-07-23 | 大连理工大学 | Multi-channel terminal reflection type optical fiber surface plasmon resonance sensing detection system |
| CN115406864A (en) * | 2021-05-26 | 2022-11-29 | 南京微纳科技研究院有限公司 | Optical detection system, method, apparatus and storage medium |
| CN113633261A (en) * | 2021-08-11 | 2021-11-12 | 南京航空航天大学 | Multichannel in-vivo pharmacokinetic analysis system based on fluorescence monitoring |
| CN115060692A (en) * | 2022-04-15 | 2022-09-16 | 深圳市儿童医院 | Optical multi-channel detection device |
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| CN2874478Y (en) * | 2005-12-12 | 2007-02-28 | 叶大林 | Multipath optical fiber in site online detecting instrument |
| US9417103B2 (en) * | 2011-09-20 | 2016-08-16 | Schlumberger Technology Corporation | Multiple spectrum channel, multiple sensor fiber optic monitoring system |
| CN103017804B (en) * | 2012-12-26 | 2015-07-29 | 中国科学院上海光学精密机械研究所 | High time synchronized multi-path optical fiber grating sensing system |
| CN103076295B (en) * | 2013-01-04 | 2015-02-04 | 武汉理工大学 | Optical fiber sensor network for multicomponent gases |
| CN104165841B (en) * | 2013-05-16 | 2016-12-28 | 上海交通大学 | The unmarked optical sensor of fiber end face and microfluid integrated morphology |
| CN203908938U (en) * | 2014-06-06 | 2014-10-29 | 长春理工大学 | Non-marked light reflection interference optical fiber biosensor |
| CN204255844U (en) * | 2014-12-11 | 2015-04-08 | 上海交通大学 | The unmarked bio-sensing fibre system of hyperchannel |
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