CN104434862A - Veterinary metamizole sodium effervescent tablets and preparation method thereof - Google Patents
Veterinary metamizole sodium effervescent tablets and preparation method thereof Download PDFInfo
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- CN104434862A CN104434862A CN201410623972.6A CN201410623972A CN104434862A CN 104434862 A CN104434862 A CN 104434862A CN 201410623972 A CN201410623972 A CN 201410623972A CN 104434862 A CN104434862 A CN 104434862A
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- dipyrone
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- effervescent tablet
- effervescent
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- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 title claims abstract description 110
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 229960000362 metamizole sodium Drugs 0.000 title abstract 6
- 239000003826 tablet Substances 0.000 claims abstract description 26
- 239000000314 lubricant Substances 0.000 claims abstract description 20
- 239000011248 coating agent Substances 0.000 claims abstract description 9
- 229940120889 dipyrone Drugs 0.000 claims description 90
- 239000000203 mixture Substances 0.000 claims description 74
- 241001465754 Metazoa Species 0.000 claims description 67
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 39
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 26
- 238000001035 drying Methods 0.000 claims description 24
- 239000002671 adjuvant Substances 0.000 claims description 20
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 20
- 239000004375 Dextrin Substances 0.000 claims description 16
- 229920001353 Dextrin Polymers 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 229930006000 Sucrose Natural products 0.000 claims description 16
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 16
- 235000019425 dextrin Nutrition 0.000 claims description 16
- 239000005720 sucrose Substances 0.000 claims description 16
- 238000005469 granulation Methods 0.000 claims description 14
- 230000003179 granulation Effects 0.000 claims description 14
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 13
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 13
- 239000007921 spray Substances 0.000 claims description 11
- 235000019359 magnesium stearate Nutrition 0.000 claims description 10
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 22
- 244000144972 livestock Species 0.000 abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 238000009395 breeding Methods 0.000 abstract description 4
- 230000001488 breeding effect Effects 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 239000000273 veterinary drug Substances 0.000 abstract description 2
- 239000008187 granular material Substances 0.000 description 37
- 241000287828 Gallus gallus Species 0.000 description 24
- 235000013330 chicken meat Nutrition 0.000 description 22
- 229940079593 drug Drugs 0.000 description 17
- 244000144977 poultry Species 0.000 description 17
- 235000013594 poultry meat Nutrition 0.000 description 17
- 238000002474 experimental method Methods 0.000 description 16
- 239000003651 drinking water Substances 0.000 description 13
- 235000020188 drinking water Nutrition 0.000 description 13
- 230000036760 body temperature Effects 0.000 description 11
- 235000013599 spices Nutrition 0.000 description 10
- 230000000857 drug effect Effects 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 238000005070 sampling Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 239000005030 aluminium foil Substances 0.000 description 6
- 230000001754 anti-pyretic effect Effects 0.000 description 6
- 239000002221 antipyretic Substances 0.000 description 6
- 229960004756 ethanol Drugs 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000007306 turnover Effects 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 208000002881 Colic Diseases 0.000 description 3
- 208000015220 Febrile disease Diseases 0.000 description 3
- 208000000112 Myalgia Diseases 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 208000013465 muscle pain Diseases 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 241000271566 Aves Species 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- JTSDBFGMPLKDCD-XVFHVFLVSA-N tilmicosin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C[C@H](C)C[C@H](C)C1)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O JTSDBFGMPLKDCD-XVFHVFLVSA-N 0.000 description 2
- 229960000223 tilmicosin Drugs 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010034107 Pasteurella infections Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229960000212 aminophenazone Drugs 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 201000005115 pasteurellosis Diseases 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention discloses veterinary metamizole sodium effervescent tablets and a preparation method thereof. The effervescent tablets comprise the following components in parts by weight: 25-50 parts of metamizole sodium tablets, 20-30 parts of effervescing agent, 5-10 parts of coating agent, 0.1-0.5 part of lubricant and 10-50 parts of accessories. The veterinary metamizole sodium effervescent tablets break the blank in the field of veterinary drugs, and break through the problem that existing veterinary metamizole sodium tablets are not dissolved into water; aiming at the characteristic of modern intensive breeding of livestock, the veterinary metamizole sodium effervescent tablets suitable for modern intensive livestock farms are developed; and the effervescent tablets can be sufficiently absorbed after being effervesced and dissolved, so that the cure rate of diseases is effectively improved and medicament waste is reduced.
Description
Technical field
The present invention relates to veterinary drug technical field, particularly relate to dipyrone effervescent tablet for animals and preparation method thereof.
Background technology
Dipyrone (Metamizole Sofium Tablets), belongs to antipyretic-antalgic and non_steroidal anti_inflammatory drug.Act on thermotaxic centre, make cutaneous vasodilation, blood flow accelerates, and perspires and increases, and heat radiation is accelerated and reduces body temperature.
Dipyrone is the compound that aminophenazone and sodium sulfite combine, and absorb rapidly in animal body, effect is very fast, and drug effect maintains 3 ~ 4 hours, and refrigeration function is comparatively remarkable, and analgesic activity is also comparatively strong, and has certain antiinflammatory and anti rheumatism action.Gastrointestinal motility is had no significant effect, for animal muscle pain, colic, rheumatism and febrile disease etc.
Dipyrone raw material water soluble, but raw material is forbidden directly using in the middle of livestock and poultry breeding industry, dipyrone tablet is due to water insoluble, use very inconvenient in the middle of intensive culture process, therefore the mode administration by spice is needed, but spice administration is very inconvenient in the actual breeding process of poultry, because livestock and poultry cultivation is all intensive now, the aquaculture model of scale, automatic waterline feedwater, automatic stockline material loading, if spice medication, can only be manually smash spice to pieces, not only time-consuming, and medicine mix uneven, cause chicken group medication uneven, absorption rate is very low, in addition, if the bad grasp of administration time is concentrated in spice medication, drug effect is slow.Therefore need to improve for analgin tablet.
Under present cultivation overall situation, when poultry are subject to antibacterial, virus or mycoplasma invasion and attack and fall ill, in most cases clinical symptoms is all with inflammatory symptoms such as heating, pain, have a strong impact on poultry to search for food normally, drink water and healthy growth, so be no matter the angle from animal welfare or Production of Livestock and Poultry, while use antibacterial and antiviral drug, antipyretic analgesic is used to be all necessary.In China, livestock and poultry cultivation value volume and range of product was numerous in recent years, the diseases such as mycoplasma, escherichia coli, Salmonella, pasteurellosis bacillus constantly occur, and the antiinflammatory antipyretic that veterinary clinic uses is less, and existing antipyretic analgesics effect is slow, action time is short, antipyretic response easily rebounds, and water insoluble use is inconvenient, can not meet clinical needs, therefore dipyrone effervescent tablet for animals of the present invention has been invented, to ensureing that livestock birds health, poultry intensive culture are significant.
Summary of the invention
The present invention is directed to the problem of dipyrone tablet for administration inconvenience in the middle of prior art, a kind of convenient drug administration is provided, and the dipyrone effervescent tablet for animals of instant effect.
Dipyrone effervescent tablet for animals of the present invention, comprises each component of following weight portion:
Dipyrone 25 ~ 50 parts,
Effervescent 20 ~ 30 parts,
Coating agent 5 ~ 10 parts,
Lubricant 0.1 ~ 0.5 part,
Adjuvant 10 ~ 50 parts.
Preferably, in order to make dipyrone effervescent tablet for animals have better dissolubility, described dipyrone effervescent tablet for animals comprises each component of following weight portion:
Dipyrone 35 ~ 45 parts,
Effervescent 22 ~ 26 parts,
Coating agent 6 ~ 8 parts,
Lubricant 0.1 ~ 0.3 part,
Adjuvant 20 ~ 40 parts.
Preferably, in order to make dipyrone effervescent tablet for animals have better dissolubility, described effervescent is by citric acid and sodium bicarbonate 2:(2.5 ~ 3 by weight) form.
Preferably, in order to better wrap up sodium bicarbonate, citric acid and sodium bicarbonate are kept apart by parcel oxidant layer, thus does not produce reaction, described coating agent is polyethylene glycol 6000.
Preferably, in order to make dipyrone effervescent tablet for animals, there is higher hardness, thus can not be broken in packaging and transportation, described lubricant is magnesium stearate, and be lubricant owing to have employed magnesium stearate, in tableting step prepared by dipyrone effervescent tablet, make the dipyrone effervescent tablet surface flatness after tabletting higher, reduce the adhesive attraction of dipyrone effervescent tablet to the pressure head of preforming device, thus easier tabletting.
Preferably, in order to make dipyrone effervescent tablet for animals have better dissolubility, described adjuvant is the mixture of dextrin and sucrose, and the weight ratio of wherein said dextrin and sucrose is 1:(1 ~ 3).
Present invention also offers a kind of preparation method for described dipyrone effervescent tablet for animals, comprise the following steps:
S10, the sodium bicarbonate of proportional quantity will be added after the coating agent melting of proportional quantity, stirs, cool, pulverizes, sieve and after drying mixture A;
S20, the dipyrone taking proportional quantity and citric acid, grinding and sieving, then obtain mixture B after mixing homogeneously with the adjuvant of proportional quantity;
S30, mixture A and mixture B mix homogeneously are obtained mixture C;
S40, in mixture C, spray into dehydrated alcohol;
S50, granulation, dry after and the mix lubricant of proportional quantity;
Pack after S60, tabletting.
Preferably, in step S10, described in sieve into cross 80 mesh sieves, described drying is for being dried to biodiversity percentage composition lower than 0.15%.
Preferably, in step S40, the amount of the dehydrated alcohol sprayed in mixture C by spray system is 10% of mixture C quality.
Preferably, in step S50, below 50 DEG C, carry out drying by automatic drying system; And/or in step S60, the tablet thickness that described tabletting obtains is 4.1mm ~ 5.5mm.
The usage of dipyrone effervescent tablet for animals of the present invention and the disease of consumption and treatment:
Dipyrone effervescent tablet for animals of the present invention can be water-soluble, convenient drug administration, and absorption for oral administration rapidly, effect is very fast, and drug effect maintains 3 ~ 4 hours, and refrigeration function is more obvious, analgesic activity is also comparatively strong, and has certain antiinflammatory and anti rheumatism action, has no significant effect gastrointestinal peristalsis.For animal muscle pain, colic, rheumatism and febrile disease.
Usage and dosage: 0.25 ~ 0.5g/ sheet, a secondary amounts, horse, cattle 4 ~ 12g; Sheep, pig 2 ~ 5g; Dog 0.5 ~ 1g; Fowl 20 becomes chicken/sheet.
The blank of field of veterinary dipyrone effervescent tablet broken by dipyrone effervescent tablet for animals provided by the invention, breach the water-fast difficult problem of existing tablet, for the feature of poultry modernization intensive culture, develop the effervescent tablet being applicable to modernization intensive livestock and poultry farms, fully absorb after its effervescent is dissolved, effectively improve the cure rate of disease, decrease drug waste.In Clinical practice, effectively ensure that dosage, improve the cure rate of livestock and poultry, and decrease drug waste.
The preparation method of dipyrone effervescent tablet for animals provided by the invention takes wet-mixed to granulate, lubricant (magnesium stearate) and effervescent (sodium bicarbonate and citric acid) is added in preparation process, be main active with dipyrone, be prepared into dipyrone effervescent tablet for animals.
Dipyrone effervescent tablet for animals provided by the invention, compared with dipyrone tablet for animals, has the following advantages:
1, rate of effervescence is fast, within 2 ~ 3 minutes, can dissolve by effervescent.
2, easy to use, drinking water administration, easily controls the drink medicine time, saving of work and time.
3, drug effect is fast, and about 60 minutes take effect, and drug effect maintains 3 ~ 4 hours, and drug effect is remarkable.
4, external effervescent dissolves completely, and without the need to effervescent course of dissolution in body, gastrointestinal reaction is little.
Detailed description of the invention
Market does not also have dipyrone effervescent tablet for animals so far, only have dipyrone tablet for animals and analgin injection for animals, analgin tablet is water-fast, and analgin injection clinical practice is more in large animal (pig, cattle and sheep).The dipyrone effervescent tablet for animals that the application provides solves the water-fast difficult problem of analgin tablet, solves the difficult problem with analgin tablet on livestock and poultry cultivation, is further elaborated below in conjunction with embodiment to technical scheme of the present invention.
Embodiment 1
The dipyrone effervescent tablet for animals of the present embodiment is composed as follows by weight:
Dipyrone: 50 parts, effervescent: 30 parts, polyethylene glycol 6000: 10 parts, lubricant: 0.5 part, adjuvant: 10 parts.
Wherein, 30 parts of effervescents are made up of by weight 2:3 citric acid and sodium bicarbonate;
Lubricant adopts magnesium stearate, and adjuvant adopts the mixture of dextrin and sucrose, and the weight ratio of wherein said dextrin and sucrose is 1:3.
Above-mentioned dipyrone effervescent tablet preparation method for animals is as follows:
1) mixture A1 is prepared: add 18 parts of sodium bicarbonate by after 10 parts of polyethylene glycol 6000 meltings, stir, cooling crush crosses 80 mesh sieves, drying (baking temperature is 50 DEG C) is carried out in granulation still, be dried to moisture lower than after 0.15% (mass percent), load in turnover barrel, obtain mixture A1, measure and seal feeding intermediate station assigned address afterwards for subsequent use;
2) mixture B1 is prepared: take the dipyrone of 50 parts, the citric acid of 12 parts pulverized 80 mesh sieves, (adjuvant is dextrin and sucrose mixture with the adjuvant of 10 parts again, wherein, in mixture, dextrin is 1:3 with the weight ratio of sucrose) mix, stir and load in turnover barrel, obtain mixture B1;
3) mix: granulation personnel press after production instruction order checks that material is complete, and mixture A1 and mixture B1 is put into granulation still, is uniformly mixed to obtain mixture C 1, setting stirring paddle speed is 30 ~ 80rpm, and the time of being uniformly mixed is 5 ~ 8 minutes;
4) hydrojet: connect spray system, ethanol solution is poured in hydrojet cylinder, continue to stir, stirring paddle speed is constant, then starts to spray ethanol solution in mixture C 1, and spouting liquid is 10% of mixture C 1 quality, and the hydrojet time is 4 ~ 6 minutes;
5) granulate: after hydrojet terminates, stir and granulate, stirring Granulation time is 10 ~ 15 minutes, makes it to form bulk, uniform granule, granulates and terminate;
6) dry: the granule after granulating is carried out drying, operate as follows: start heating system, setting heat source temperature 50 DEG C, product maximum temperature 50 DEG C, then start after automatic drying system (stir, overturn, tilt) starts drying and keep a record, once per hour, after two hours, loss on drying is surveyed in sampling, and record, moisture Control 1% (mass percent) below, begin to cool down, be cooled to 30 DEG C, and carry out dry record;
7) granulate, always mix
Dried granule Fast granulate machine is carried out granulate, and the granule crossed by granulate is placed in mixer, adds 0.5 part of magnesium stearate as lubricant, mix homogeneously, and incorporation time is 15 ~ 20 minutes, measures drug content;
8) tabletting: by granulate, total mixed after material carry out tabletting, be pressed into every sheet 1g (every sheet is containing dipyrone 0.5g).Operate as follows: setting tabletting speed 50,000 slices/hour, tab weight, hardness (4.0 ~ 10.0kgf), thickness (4.1 ~ 5.5mm), inspection aesthetic finish, after meeting the requirements, to install interlock work with Aluminium Foil Package;
Within in tableting processes every 15 minutes, survey sample average sheet weight, hardness, guarantee that tablet weight variation is within ± 5% allowed band, and record, check indoor temperature (controlling at 18 ~ 26 DEG C) relative humidity (controlling below 20%) and record;
9) pack: packaging of aluminium foil bag, heat-sealing temperature controls at 200 ~ 250 DEG C, and each start sampling in 1 hour send laboratory to do leak check, and leak check is done in sampling in every 2 hours afterwards.
Through experiment, be placed in water by the dipyrone effervescent tablet for animals in the present embodiment, 2 points and 30 seconds time, complete effervescent dissolves.
Embodiment 2
The dipyrone effervescent tablet for animals of the present embodiment, this dipyrone effervescent tablet for animals is composed as follows by weight:
Dipyrone: 25 parts, effervescent: 20 parts, polyethylene glycol 6000: 5 parts, lubricant: 0.1 part, adjuvant: 50 parts.
Wherein, be made up of by weight 2:2.5 citric acid and sodium bicarbonate in 20 parts of effervescents;
Lubricant adopts magnesium stearate, and adjuvant adopts the mixture of dextrin and sucrose, and the weight ratio of wherein said dextrin and sucrose is 1:1.
1) mixture A2 is prepared: add 11.1 parts of sodium bicarbonate by after 5 parts of polyethylene glycol 6000 meltings, stir, cooling crush crosses 80 mesh sieves, drying (baking temperature is 50 DEG C) is carried out in granulation still, be dried to moisture lower than after 0.15% (mass percent), load in turnover barrel, obtain mixture A2, measure and seal feeding intermediate station assigned address afterwards for subsequent use;
2) mixture B2 is prepared: take the dipyrone of 25 parts, the citric acid of 8.9 parts pulverized 80 mesh sieves, (adjuvant is dextrin and sucrose mixture with the adjuvant of 50 parts again, wherein, in mixture, dextrin is 1:1 with the weight ratio of sucrose) mix, stir and load in turnover barrel, obtain mixture B2;
3) mix: granulation personnel press after production instruction order checks that material is complete, and mixture A2 and mixture B2 is put into granulation still, is uniformly mixed to obtain mixture C 2, setting stirring paddle speed is 30 ~ 80rpm, and the time of being uniformly mixed is 5 ~ 8 minutes;
4) hydrojet: connect spray system, ethanol solution is poured in hydrojet cylinder, continue to stir, stirring paddle speed is constant, then starts to spray ethanol solution in mixture C 2, and spouting liquid is 10% of mixture C 2 quality, and the hydrojet time is 4 ~ 6 minutes;
5) granulate: after hydrojet terminates, stir and granulate, stirring Granulation time is 10 ~ 15 minutes, makes it to form bulk, uniform granule, granulates and terminate;
6) dry: the granule after granulating is carried out drying, operate as follows: start heating system, setting heat source temperature 50 DEG C, product maximum temperature 50 DEG C, then start after automatic drying system (stir, overturn, tilt) starts drying and keep a record, once per hour, after two hours, loss on drying is surveyed in sampling, and record, moisture Control 1% (mass percent) below, begin to cool down, be cooled to 30 DEG C, and carry out dry record;
7) granulate, always mix
Dried granule Fast granulate machine is carried out granulate, and the granule crossed by granulate is placed in mixer, adds 0.1 part of magnesium stearate as lubricant, mix homogeneously, and incorporation time is 15 ~ 20 minutes, measures drug content;
8) tabletting: by granulate, total mixed after material carry out tabletting, be pressed into every sheet 1g (every sheet is containing dipyrone 0.25g).Operate as follows: setting tabletting speed 50,000 slices/hour, tab weight, hardness (4.0 ~ 10.0kgf), thickness (4.1 ~ 5.5mm), inspection aesthetic finish, after meeting the requirements, to install interlock work with Aluminium Foil Package;
Within in tableting processes every 15 minutes, survey sample average sheet weight, hardness, guarantee that tablet weight variation is within ± 5% allowed band, and record, check indoor temperature (controlling at 18 ~ 26 DEG C) relative humidity (controlling below 20%) and record;
9) pack: packaging of aluminium foil bag, heat-sealing temperature controls at 200 ~ 250 DEG C, and each start sampling in 1 hour send laboratory to do leak check, and leak check is done in sampling in every 2 hours afterwards.
Through experiment, be placed in water by the dipyrone effervescent tablet for animals in the present embodiment, 2 points and 10 seconds time, complete effervescent dissolves.
Embodiment 3
The dipyrone effervescent tablet for animals of the present embodiment, this dipyrone effervescent tablet for animals is composed as follows by weight:
Dipyrone: 35 parts, effervescent: 28 parts, polyethylene glycol 6000: 8 parts, lubricant: 0.3 part, adjuvant: 29 parts.
Wherein, 28 parts of effervescents are made up of by weight 2:2.8 citric acid and sodium bicarbonate;
Lubricant adopts magnesium stearate, and adjuvant adopts the mixture of dextrin and sucrose, and the weight ratio of wherein said dextrin and sucrose is 1:2.
1) mixture A3 is prepared: add 16.3 parts of sodium bicarbonate by after 8 parts of polyethylene glycol 6000 meltings, stir, cooling crush crosses 80 mesh sieves, drying (baking temperature is 50 DEG C) is carried out in granulation still, be dried to moisture lower than after 0.15% (mass percent), load in turnover barrel, obtain mixture A3, measure and seal feeding intermediate station assigned address afterwards for subsequent use;
2) mixture B3 is prepared: take the dipyrone of 35 parts, the citric acid of 11.7 parts pulverized 80 mesh sieves, (adjuvant is dextrin and sucrose mixture with the adjuvant of 29 parts again, wherein, in mixture, dextrin is 1:2 with the weight ratio of sucrose) mix, stir and load in turnover barrel, obtain mixture B3;
3) mix: granulation personnel press after production instruction order checks that material is complete, and mixture A3 and mixture B3 is put into granulation still, is uniformly mixed to obtain mixture C 3, setting stirring paddle speed is 30 ~ 80rpm, and the time of being uniformly mixed is 5 ~ 8 minutes;
4) hydrojet: connect spray system, ethanol solution is poured in hydrojet cylinder, continue to stir, stirring paddle speed is constant, then starts to spray ethanol solution in mixture C 3, and spouting liquid is 10% of mixture C 3 quality, and the hydrojet time is 4 ~ 6 minutes;
5) granulate: after hydrojet terminates, stir and granulate, stirring Granulation time is 10 ~ 15 minutes, makes it to form bulk, uniform granule, granulates and terminate;
6) dry: the granule after granulating is carried out drying, operate as follows: start heating system, setting heat source temperature 50 DEG C, product maximum temperature 50 DEG C, then start after automatic drying system (stir, overturn, tilt) starts drying and keep a record, once per hour, after two hours, loss on drying is surveyed in sampling, and record, moisture Control 1% (mass percent) below, begin to cool down, be cooled to 30 DEG C, and carry out dry record;
7) granulate, always mix
Dried granule Fast granulate machine is carried out granulate, and the granule crossed by granulate is placed in mixer, adds 0.3 part of magnesium stearate as lubricant, mix homogeneously, and incorporation time is 15 ~ 20 minutes, measures drug content;
8) tabletting: by granulate, total mixed after material carry out tabletting, be pressed into every sheet 1g (every sheet is containing dipyrone 0.35g).Operate as follows: setting tabletting speed 50,000 slices/hour, tab weight, hardness (4.0 ~ 10.0kgf), thickness (4.1 ~ 5.5mm), inspection aesthetic finish, after meeting the requirements, to install interlock work with Aluminium Foil Package;
Within in tableting processes every 15 minutes, survey sample average sheet weight, hardness, guarantee that tablet weight variation is within ± 5% allowed band, and record, check indoor temperature (controlling at 18 ~ 26 DEG C) relative humidity (controlling below 20%) and record;
9) pack: packaging of aluminium foil bag, heat-sealing temperature controls at 200 ~ 250 DEG C, and each start sampling in 1 hour send laboratory to do leak check, and leak check is done in sampling in every 2 hours afterwards.
Through experiment, be placed in water by the dipyrone effervescent tablet for animals in the present embodiment, 2 points and 20 seconds time, complete effervescent dissolves.
Each embodiment various raw material used is commercially available above.
Wherein dipyrone is the dipyrone raw material that Shandong Xinhua Pharmaceutical Factory is produced, and citric acid is that Shandong Lemon Biochemical Co., Ltd. produces.Sodium bicarbonate is that Hebei Huachen Pharmaceutical Co., Ltd. produces.
Spray system in embodiment 1 ~ 3 and automatic drying system are existing equipment.
The dipyrone effervescent tablet for animals that embodiment 1 ~ 3 provides is mainly used in animal muscle pain, colic, rheumatism and febrile disease.
Usage and dosage: 0.25 ~ 0.5g dipyrone/sheet, a secondary amounts, horse, cattle: 4 ~ 12g; Sheep, pig: 2 ~ 5g; Dog: 0.5 ~ 1g; Fowl: 20 become chicken/sheet.
Zoopery
Laboratory animal: choose 2000, broiler breeding field, Suburb of Shijiazhuang white meat-type chickens, 25 ages in days, carry out the experiment of manual time's cost.
Trial drug: the dipyrone effervescent tablet for animals of embodiment 1, control drug is that the analgin tablet agent content specification that Sichuan Kang'erhao Animal Pharmaceutical Co., Ltd. produces is every sheet containing dipyrone 0.5g.
Experiment content: 2000 white meat-type chickens are divided into two groups, experimental group 1000 and matched group 1000, the dipyrone effervescent tablet of experimental group in embodiment 1, matched group analgin tablet, detailed directions is: 1000 white meat-type chickens 25 age in days daily ingestion amounts are 250 jin, daily drink amount is 500 jin, drinking water administration after experimental group dissolves with the dipyrone effervescent tablet in embodiment 1 50, the time of dissolving 50 dipyrone effervescent tablets is 2 ~ 3 minutes, again 2 minutes used times add automatic waterline after chicken to troop middle drinking-water 120 jin, namely chicken group is allowed to be 4 ~ 5 minutes the medicine-feeding time, drinking water administration is convenient, concentrate medication, drug effect is fast, absorb fast.
Matched group analgin tablet 50, manually smash to pieces and mix thoroughly 120 jin of material (broiler be generally with particulate material in the majority, there is spice uneven, cause chicken group medication uneven) time be 20 ~ 30 minutes, and added about 10 ~ 30 minutes material used times by craft or mechanical system to chicken group, the time namely allowing chicken group add medicine to is 30 ~ 60 minutes, and spice administration is time-consuming, medication is uneven, and onset is slow.
Can find that dipyrone effervescent tablet for animals of the present invention has drinking water administration by this experiment, drug effect is fast, and time and labour saving, uses advantage very easily.
The dipyrone effervescent tablet for animals zoopery that the embodiment of the present invention 1 ~ 3 provides and result:
Experiment 1: the antipyretic experiment of dipyrone effervescent tablet for animals
Medicine: dipyrone effervescent tablet for animals (1 20 chicken), analgin tablet (1 20 chicken)
Newcastle IV is (La Sota strain), is purchased from YEBIO Bioengineering Co., Ltd of Qingdao
Laboratory animal: laying hen (normal body temperature 40.5 DEG C ~ 41.5 DEG C), mean body temperature is the healthy laying hen 100 of 40.9 DEG C for three days on end, is divided into A1, A2, A3, B, C five groups at random, often organizes 20.
Experimentation: each group poultry 5 times amount immune newcastle IV of drinking water is (La Sota strain), then at immunity latter 12 hours, 18 hours, 24 hours, 25 hours, 26 hours, 27 hours, 28 hours take temperatures, record average data, the results are shown in Table 1:
Table 1 laboratory animal takes the temperature data record after vaccine
As can be seen from upper table data, 5 times amount drink water immune newcastle IV be (La Sota strain) after 12 hours each group laying hen body temperature start to raise, peak after 24 hours, now, to the dipyrone effervescent tablet for animals (1 20 chicken) in A1 group drinking-water embodiment 1, to the dipyrone effervescent tablet for animals (1 20 chicken) in A2 group drinking-water embodiment 2, to the dipyrone effervescent tablet for animals (1 20 chicken) in A3 group drinking-water embodiment 3, to B group spice analgin tablet (1 20 chicken), C group need not any medicine.Then at 25 hours, 26 hours, 27 hours, 28 hours take temperatures of having drunk vaccine, and average data is recorded.
Result: as can be seen from Table 1,5 times amount immune newcastle IV of drinking water is after (La Sota strain), each group of laying hen body temperature obviously rises, after 24 hours, body temperature reaches peak, with dipyrone effervescent tablet for animals drinking-water A1, A2, A3 tri-groups of body temperature 1 hour basic controlling laying hen, and by the B group of analgin tablet spice at 2 hours basic controlling laying hen body temperature.Experiment can be found out thus, (effervescent dissolves dipyrone effervescent tablet for animals of the present invention in vitro, drinking-water uses, gastrointestinal reaction is little, drug effect is not by the impact of gastrointestinal tract pH value) bring down a fever soon, and antipyretic successful of bringing down a fever is better than analgin tablet (spice absorbs slow, and effect of bringing down a fever is slow).
Experiment 2: the experiment of Synergistic treatment poultry respiratory infection
Choose Hebei chicken house, it is (spiritual depressed that veterinary clinic is judged to be that chicken respiratory infects, body temperature is elevated to 44 degree, drinking-water of searching for food reduces, there is serious respiratory symptom, comprise cough, shed tears, swollen head swells face, heating, neurological disorders) sick chicken, be divided into A1, A2, A3, B, C five groups at random, all adopt the tilmicosin solution of same dose to throw something and feed treatment.The dipyrone effervescent tablet for animals of the embodiment of the present invention 1 is closed in A1 assembly simultaneously, the dipyrone effervescent tablet for animals of embodiment 2 is closed in A2 assembly, and the dipyrone effervescent tablet for animals of embodiment 3 is closed in A3 assembly, 1/20 chickens, analgin tablet for animals 1/20 chickens are closed in B assembly, and C group only uses tilmicosin solution.
Result: observe treatment case in one week, pay a return visit the record state of an illness, criterion (1) is cured: medication 3 future trouble patient and his family fowl symptoms disappear completely, and spirit, body temperature, appetite recover normal.(2) effective: medication three future trouble patient and his family fowl symptoms disappear substantially, and spirit, body temperature, appetite make moderate progress.(3) invalid: medication three future trouble patient and his family fowl symptoms do not disappear, sb.'s illness took a turn for the worse or death.Each experimental group treatment situation is as shown in table 2:
Table 2 each experimental group treatment situation
Can significantly find out in table 2, it is evident in efficacy that antibiotic therapy poultry respiratory bacteriological infection worked in coordination with by this dipyrone effervescent tablet.Effective percentage in experiment A1 group one week up to 98.5%, cure rate reaches 97.8%; Effective percentage in experiment A2 group one week is up to 97.1%, and cure rate reaches 95.7%; Effective percentage in experiment A3 group one week is up to 97.7%, and cure rate reaches 96.8%; Use the interior effective percentage of the experiment B group one week of analgin tablet to be 92.8%, cure rate 90.5%; Any antipyretic analgesics is not used only to be only 85.8% with the experiment C group effective percentage of antibiotic therapy, to cure 80.6%.Draw the intensive livestock and poultry cultivation process of modernization from above-mentioned two contrast test data, use dipyrone effervescent tablet for animals can greatly improve disease cured rate and effective percentage, the invention of dipyrone effervescent tablet is significant for guarantee livestock birds health, the intensive livestock and poultry cultivation of modernization.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (10)
1. a dipyrone effervescent tablet for animals, is characterized in that, comprises each component of following weight portion:
Dipyrone 25 ~ 50 parts,
Effervescent 20 ~ 30 parts,
Coating agent 5 ~ 10 parts,
Lubricant 0.1 ~ 0.5 part,
Adjuvant 10 ~ 50 parts.
2. dipyrone effervescent tablet for animals according to claim 1, is characterized in that, comprises each component of following weight portion:
Dipyrone 35 ~ 45 parts,
Effervescent 22 ~ 26 parts,
Coating agent 6 ~ 8 parts,
Lubricant 0.1 ~ 0.3 part,
Adjuvant 20 ~ 40 parts.
3. dipyrone effervescent tablet for animals according to claim 1 and 2, is characterized in that, described effervescent is by citric acid and sodium bicarbonate 2:(2.5 ~ 3 by weight) form.
4. dipyrone effervescent tablet for animals according to claim 1 and 2, is characterized in that, described coating agent is polyethylene glycol 6000.
5. dipyrone effervescent tablet for animals according to claim 1 and 2, is characterized in that, described lubricant is magnesium stearate.
6. dipyrone effervescent tablet for animals according to claim 1 and 2, is characterized in that, described adjuvant is the mixture of dextrin and sucrose, and the weight ratio of wherein said dextrin and sucrose is 1:(1 ~ 3).
7. the preparation method of the dipyrone effervescent tablet for animals described in any one of claim 1 ~ 6, is characterized in that, comprise the following steps:
S10, the sodium bicarbonate of proportional quantity will be added after the coating agent melting of proportional quantity, stirs, cool, pulverizes, sieve and after drying mixture A;
S20, the dipyrone taking proportional quantity and citric acid, grinding and sieving, then obtain mixture B after mixing homogeneously with the adjuvant of proportional quantity;
S30, mixture A and mixture B mix homogeneously are obtained mixture C;
S40, in mixture C, spray into dehydrated alcohol;
S50, granulation, dry after and the mix lubricant of proportional quantity;
Pack after S60, tabletting.
8. the preparation method of dipyrone effervescent tablet for animals according to claim 7, is characterized in that,
In step S10, described in sieve into cross 80 mesh sieves, described drying is for being dried to biodiversity percentage composition lower than 0.15%.
9. the preparation method of dipyrone effervescent tablet for animals according to claim 7, is characterized in that, in step S40, the amount of the dehydrated alcohol sprayed in mixture C by spray system is 10% of mixture C quality.
10. the preparation method of dipyrone effervescent tablet for animals according to claim 7, is characterized in that, in step S50, carries out drying by automatic drying system below 50 DEG C; And/or in step S60, the tablet thickness that described tabletting obtains is 4.1mm ~ 5.5mm.
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| CN106236727A (en) * | 2016-08-30 | 2016-12-21 | 林州中农颖泰生物肽有限公司 | A kind of dipyrone effervescent tablet and preparation method thereof |
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