CN104422779A - Automatic immune analyzer - Google Patents

Abstract

The invention discloses a fully automatic immunoassay analyzer, which includes a control component, a frame, an adsorption transmission component, a placement component for placing a reaction cup and a TIP head, a transmission component, a sample addition component, a reaction disk, a cleaning component and a light quantity detection device, wherein the transmission component is located between the placement component and the sample addition component, the sample addition component includes a sample component, a reagent component and a sample suction component, the sample suction component is located between the reaction disk, the sample component and the reagent component, the control component controls the adsorption transmission component to place the reaction cup in the reaction disk, the TIP head is installed on the sample suction component through the transmission component, the sample and reagent are added to the reaction cup of the reaction disk through the sample suction component, and then the sample and reagent are cleaned through the cleaning device, and then the light quantity detection device is controlled to detect. The whole process of the invention device from sample addition to result output is completely completed automatically by the instrument, and the operation is convenient and the degree of automation is high.

Description

Automatic immune analyzer

technical field

The invention relates to the field of medical equipment, in particular to a fully automatic immune analyzer.

Background technique

Biochemical Immunity Analyzer (HF) is an instrument used to detect and analyze life chemical substances, and provide information basis for clinical diagnosis, treatment and prevention of diseases and health status. Most of the existing domestic self-developed varieties are semi-automatic, with slow analysis speed and large reagent consumption. Compared with foreign products, there is still a considerable gap in automation degree, precision, process quality, reliability and stability. .

Contents of the invention

The purpose of the present invention is to provide a fully automatic analyzer with convenient operation.

To achieve the above object, the present invention adopts the following technical solutions:

A fully automatic immune analyzer for detecting and analyzing blood biochemical indicators, which includes a control component, a frame with a beam, an adsorption transmission component, a placement component for placing a reaction cup and a TIP head, a transmission component, and a sample addition Components, reaction discs, cleaning components and light detection devices, the control components, adsorption transfer components, placement components, transfer components, sample loading components, reaction discs, cleaning components and light detection devices are arranged on the frame, The transfer component is located between the placement component and the sample loading component, the sample loading component includes a sample component, a reagent component, and a sample suction component, and the sample suction component is located between the reaction tray, sample component and In the middle of the reagent assembly, the control assembly controls the adsorption transfer assembly to place the cuvette into the reaction tray, installs the TIP head on the sample suction assembly through the transfer assembly, and installs the TIP head on the suction assembly through the suction assembly. The sample component adds samples and reagents into the reaction cups of the reaction disk, and then cleans them through the cleaning device, and then controls the light quantity detection device to perform detection.

The adsorption conveying assembly includes a first sliding assembly located on the crossbeam, a second sliding assembly perpendicular to the crossbeam on the horizontal plane, a third sliding assembly perpendicular to the crossbeam on the vertical plane, several connecting blocks and adsorption heads, the described The connecting block is used to connect the sliding components, and the suction head is located at the lower end of the third sliding component.

The placement assembly includes a placement cabinet, a vertical movement control assembly, a horizontal movement control assembly, and several TIP placement frames and cuvette placement frames stored in the placement cabinet. The vertical movement control assembly is located on the side of the placement cabinet , the horizontal movement control assembly is located at the lower end of the placement cabinet.

The transmission assembly includes a base, a slide bar and a slide block, the base is fixed on the frame, the slide bar is fixed on the base, the slide block passes through the slide bar, and can be moved on the slide Move freely on the pole.

The transmission assembly also includes a hollow rod that is fixed on the base body and passes through the base body to the bottom of the frame. The slider is provided with a hollow groove. When the slider slides above the hollow rod, the The hollow groove described above corresponds to the position of the hollow rod.

The cleaning assembly includes a cleaning arm, a cleaning pipe and a cleaning disc set. The cleaning arm is freely movable on the beam guide rail, and the cleaning tube and the cleaning disc set are located under the cleaning arm.

Both the sample assembly and the reagent assembly include a rotating chassis, a sample adding block and a number of sample inserts, a chute and a sliding part are provided in the sample adding block, and the sample inserts are placed on the sample adding block, And it can move to the rotating chassis along the direction of the chute under the action of the sliding piece.

Preferably, the lower end of the sample suction component is provided with a one-way pressurized pump pneumatically connected to it, which is used to control the adsorption amount of the sample suction component.

Preferably, the reagent assembly further includes a cover, and the cover is placed on the periphery of the rotating chassis.

After adopting the above technical solution, the present invention has the following advantages compared with the existing background technology:

1. The whole process of the inventive device from sample addition to result output is completely automatically completed by the instrument. The operator only needs to put the sample on the sample block of the analyzer, select the program to start the instrument and wait for the inspection report. It is easy to operate and has a high degree of automation.

2. The sample suction component is located in the center of the reaction plate, sample component and reagent component. The sample suction component completes the operation of sampling and suction of reagents. The one-way pressurized pump controls the adsorption amount of the sample suction component. The layout is reasonable and the structure is simple.

3. The placement component includes a movement control component in two directions. Just arrange the TIP head placement frame and the reaction cup placement frame in the placement cabinet, and then adjust to the appropriate position through the movement control component, with high precision and improved detection. efficiency.

4. There is a hollow groove on the slider of the transmission component. When the slider slides to the top of the hollow rod, the hollow groove corresponds to the position of the hollow rod. The suction component drops the discarded TIP head from the hollow groove and directly falls into the hollow rod The interior leads to the trash can under the rack, ensuring the cleanliness of the environment.

5. Both the sample assembly and the reagent assembly include a rotating chassis, a sample adding block and a number of sample inserts. The sample inserts are placed on the sample adding block and can be moved to the rotating chassis along the direction of the chute under the action of the slider. Since the sample inserts are detachable, sample inserts of different specifications, that is, different numbers of through-holes, can be used to place blood samples or reagent samples.

6. The reagent assembly is equipped with a peripheral cover on the rotating chassis to prevent reagent contamination.

Description of drawings

Fig. 1 is the front view of the present invention;

Fig. 2 is the three-dimensional structure schematic diagram of the present invention;

Fig. 3 is a schematic structural diagram of the adsorption transport assembly of the present invention;

Fig. 4 is a structural schematic diagram of the placement assembly of the present invention;

Fig. 5 is a schematic structural diagram of a sample assembly of the present invention;

Fig. 6 is a schematic structural diagram of the conveying assembly of the present invention.

Explanation of main component symbols:

100: Rack, 110: Beam, 200: Light quantity detection device, 300: Adsorption transmission assembly, 310: First slide assembly, 311: First slide rail, 312: First belt transmission member, 320: Second slide assembly, 321: second sliding rail, 322: second belt transmission part, 330: third sliding assembly, 331: third sliding rail, 332: third belt transmission part, 341: first connecting block, 342: second connecting block , 350: suction head, 400: placement assembly, 410: placement cabinet, 420: vertical movement control assembly, 430: horizontal movement control assembly, 440: TIP head placement frame, 450: cuvette placement frame, 500: transfer assembly, 510: seat body, 520: slide rod, 530: slide block, 531: hollow groove, 540: hollow rod, 610: sample assembly, 611: rotating chassis, 612: sample insert block, 613: sample adding block, 614: slide Tank, 615: slide, 620: reagent component, 630: sample suction component, 640: one-way pressurized pump, 700: reaction plate, 800: cleaning component, 810: cleaning arm, 820: cleaning tube, 830: cleaning plate Group, 910: cuvette, 920: TIP head.

Detailed ways

In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

The biochemical immune analyzer is mainly used to measure various biochemical indicators in human body fluids, including routine biochemical indicators such as blood routine, myocardial enzyme spectrum, blood sugar and blood lipids, liver function, and immunoglobulin.

As shown in Figures 1 and 2, the fully automatic immune analyzer disclosed in this invention includes a control assembly, a frame 100 provided with a beam 110, and an adsorption transport assembly 300 located on the beam 110 for placing the cuvette 910 and the TIP head 920 includes the placement component 400 , the transport component 500 , the sample loading component, the reaction disk 700 , the cleaning component 800 , and the light quantity detection device 200 . The control unit, adsorption transport unit 300 , placement unit 400 , transport unit 500 , sample loading unit, reaction disk 700 , cleaning unit 800 and light detection device 200 are arranged on the frame 100 .

As shown in Figure 3: the adsorption transfer assembly 300 includes a first slide assembly 310 located on the beam 110, a second slide assembly 320 located on a horizontal plane, a third slide assembly 330 located on a vertical plane, a first connecting block 341, a second Connecting block 342 and suction head 350, the first slide assembly 310 comprises the first slide rail 311 and the first belt transmission part 312 fixed on its lower end, the first connection block 341 is fixed on the first belt transmission part 312 and with the second The slide assembly 320 is connected. The second sliding assembly 320 includes a second sliding rail 321 and a second belt transmission member 322 fixed on a side end thereof. The second connecting block 342 is fixed on the second belt transmission member 322 and connected to the third sliding assembly 330 . The third sliding assembly 330 includes a third sliding rail 331 and a third belt transmission member 332 fixed on the lower end of the second connecting block 342 . The suction head 350 is located at the lower end of the third slide rail 331 .

As shown in Figure 4: the placement assembly 400 includes a placement cabinet 410, a vertical movement control assembly 420, a horizontal movement control assembly 430, and several TIP head placement frames 440 and cuvette placement frames 450 stored in the placement cabinet 410, which move vertically The control assembly 420 is located at the side of the storage cabinet 410 , and the horizontal movement control assembly 430 is located at the lower end of the storage cabinet 410 .

The sample loading assembly includes a sample assembly 610 , a reagent assembly 620 , and a sample suction assembly 630 . The sample aspirating component 630 is located in the middle of the reaction disk 700 , the sample component 610 and the reagent component 620 . The reaction disk 700, the sample assembly 610 and the reagent assembly 620 are controlled by the control assembly to rotate axially, and the sample suction assembly 630 can rotate 360 degrees. As shown in FIG. 5 , both the sample assembly 610 and the reagent assembly 620 include a rotating chassis 611 , a sample adding block 613 and several sample insert blocks 612 . The sample adding block 613 is provided with a chute 614 and a slider 615 . The sample insert 612 is placed on the sample adding block 613 and can be moved to the rotating chassis 611 along the chute 614 under the action of the slider 615 .

As shown in FIG. 2 , the lower end of the sample suction assembly 630 is provided with a one-way pressurized pump 640 pneumatically connected thereto, which is used to control the adsorption amount of the sample suction assembly 630 . The reagent assembly 620 also includes a cover (not shown in the figure), which is placed on the periphery of the rotating chassis 611 to play an isolation role and prevent the reagents from being contaminated.

As shown in Figure 6, the transfer assembly 500 is located between the placement assembly 400 and the sample loading assembly, the transfer assembly 500 includes a base 510, a slide bar 520, and a slider 530, which are fixed on the base 510 and pass through the base 510 to the rack 100 Hollow rod 540 at the bottom. The sliding block 530 is provided with a hollow groove 531 , the base body 510 is fixed on the frame 100 , the sliding bar 520 is fixed on the base body 510 , the sliding block 530 passes through the sliding bar 520 , and can move freely on the sliding bar 520 .

The cleaning assembly 800 includes a cleaning arm 810 , a cleaning pipe 820 and a cleaning disc set 830 . The cleaning arm 810 is located on the beam 110 and can move freely. The cleaning tube 820 and the cleaning disc set 830 are located below the cleaning arm 810 .

After collecting the blood sample, turn on the instrument, select the test items and corresponding reagents; run the test, the analyzer will automatically perform steps such as adding samples, adding reagents, incubating reactions, photoelectric testing, and washing. The main workflow is as follows:

Step 1: Arrange the empty cuvettes 910 in the cuvette placement frame 450 , arrange the TIP heads 920 in the TIP head placement frame 440 , and arrange the two kinds of placement frames in the placement cabinet 410 vertically. The vertical movement control component 420 moves the placement frame down from the placement cabinet 410 to the horizontal movement control component 430 , and the horizontal movement control component 430 moves a set of TIP head placement frame 440 and cuvette placement frame 450 to below the beam 110 .

Step 2: insert the collected blood sample on the sample insert 612 of the sample assembly 610 , and place the reagent bottle on the sample insert 612 of the reagent assembly 620 . Place the sample insert 612 in the chute 614 of the sample adding block 613, the bottom of the sample insert 612 is matched with the slider 615, and the slider 615 moves in the chute 614 while driving the sample adding block 613 to enter and lock it On the rotating chassis 611. The rotating chassis 611 rotates at an angle, so that the blood sample and the reagent bottle are close to the sample suction assembly 630 .

Step 3: The suction head 350 moves along the beam 110 on the first sliding assembly 310, moves along the horizontal plane and the vertical plane through the second sliding assembly 320 and the third sliding assembly 330, and adjusts to the position of the cuvette under the action of the control assembly Above the frame 450 , the adsorption head 350 adsorbs the wall of the cuvette 910 , moves it and places it on the reaction disk 700 .

Step 4: The suction head 350 is adjusted to the top of the TIP head placement frame 440 to hold the TIP head 920 . Simultaneously, the slider 530 on the delivery assembly 500 moves along the slider 520 to the end of the base body 510 close to the suction delivery assembly 300 , and the suction head 350 places the TIP head 920 on the slider 530 .

Step 5: The slider 530 moves along the slide bar 520 to above the hollow rod 540 , and the hollow groove 531 corresponds to the position of the hollow rod 540 .

Step 6: The sample suction assembly 630 rotates onto the slider 530, grabs the TIP head 920 on it, and then rotates onto the sample insert 612 of the sample assembly 610, and uses the TIP head 920 to draw an appropriate amount of blood samples, and pressurizes in one direction The pump 640 can control the adsorption amount of the sample suction assembly 630 .

Step 7: The sample suction assembly 630 is rotated onto the reaction disk 700, and the blood sample sucked in the TIP head 920 is dropped into the cuvette 910, and then the sample suction assembly 630 is rotated above the hollow groove 531 of the slider 530, and the contaminated blood sample The TIP head 920 is loosened, so that the polluted TIP head 920 enters the hollow rod 540 through the hollow groove 531 and leads to the trash can at the bottom of the frame 100 .

Step 8: The suction head 350 is adjusted to the top of the TIP head placement frame 440 again, absorbs the new TIP head 920 , and places it on the slider 530 . The sample suction assembly 630 rotates above the slider 530 , absorbs the clean TIP head 920 and rotates onto the reagent assembly 620 , and uses the TIP head 920 to suck the reagent in the reagent bottle.

Step 9: The sample suction assembly 630 is rotated onto the reaction disk 700 and the reagent sucked by the TIP head 920 is dropped into the cuvette 910 to make the blood in the cuvette 910 react with the reagent. Then the sample suction assembly 630 is also rotated to the top of the hollow groove 531 of the slider 530, and the polluted TIP head 920 is released, so that the polluted TIP head 920 enters the hollow rod 540 from the hollow groove 531 and leads to the bottom of the frame 100. In the trash can.

Step 10: After the reaction is completed, the cleaning arm 810 grabs the cuvette 910 on the reaction disk 700 and puts it into the light detection device 200 for detection.

Step 11: After the detection is completed, the cleaning arm 810 grabs the cuvette 910 to the cleaning tray set 830 to clean the cuvette 910 .

The above completes a work cycle, and the time length of each work cycle is consistent. In each working cycle, each action component works in accordance with the prescribed action sequence, and completes the actions of adding blood samples, adding reagents, photoelectric data collection, and automatic cleaning of cuvettes. In this way, the work cycle is continuously executed repeatedly, so as to complete multiple projects continuously with high efficiency test.

The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of changes or modifications within the technical scope disclosed in the present invention. Replacement should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope of the claims.

Claims (9)

1. an automatic lmunoassays analyzer, for detecting the biochemical indicator of analyzing blood, is characterized in that: it comprises Control Component, be provided with the frame of crossbeam, absorption transfer assembly, for the placing modules of placing response cup and TIP head, transfer assembly, application of sample assembly, reaction tray, cleaning assembly and light quantity pick-up unit, described Control Component, absorption transfer assembly, placing modules, transfer assembly, application of sample assembly, reaction tray, cleaning assembly and light quantity pick-up unit are located in described frame, and described transfer assembly is between described placing modules and application of sample assembly, and described application of sample assembly comprises Sample assemblies, reagent assembly, inhale sample assembly, described suction sample assembly is positioned at described reaction tray, the centre of Sample assemblies and reagent assembly, reaction cup is placed in described reaction tray by the absorption transfer assembly described in described Control Component controls, by described transfer assembly, TIP head is arranged on suction sample assembly, by described suction sample assembly, sample and reagent are added in the reaction cup of described reaction tray, cleaned by described cleaning device again, then control described light quantity pick-up unit and detect.

2. automatic lmunoassays analyzer as claimed in claim 1, it is characterized in that: described absorption transfer assembly comprises the first slide assemblies be positioned on crossbeam, the second slide assemblies of surface level is positioned at perpendicular to crossbeam, the 3rd slide assemblies of vertical plane is positioned at perpendicular to crossbeam, some contiguous blocks and adsorption head, described contiguous block is for connecting each slide assemblies, and described adsorption head is positioned at the 3rd slide assemblies bottom.

3. automatic lmunoassays analyzer as claimed in claim 1 or 2, it is characterized in that: described placing modules comprises placement cabinet, vertical mobile Control Component, move horizontally Control Component and some TIP head placing frames of being accommodated in placement cabinet and reaction cup placing frame, described vertical mobile Control Component is positioned at placement cabinet side, and the described Control Component that moves horizontally is positioned at placement cabinet lower end.

4. automatic lmunoassays analyzer as claimed in claim 3, it is characterized in that: described transfer assembly comprises pedestal, slide bar and slide block, described pedestal is fixed in frame, and described slide bar is fixed on pedestal, described slide block through slide bar, and can move freely on slide bar.

5. automatic lmunoassays analyzer as claimed in claim 4, it is characterized in that: described transfer assembly also comprises and is fixed on pedestal, and lead to the hollow stem bottom frame through pedestal, described slide block is provided with groove, time above described skid to hollow stem, described groove is corresponding with hollow stem position.

6. automatic lmunoassays analyzer as claimed in claim 5, it is characterized in that: described cleaning assembly comprises cleaning arm, purge pipe and cleaning disc group, described cleaning arm is positioned on beam guideway and can move freely, and described purge pipe and cleaning disc group are positioned at below cleaning arm.

7. automatic lmunoassays analyzer as claimed in claim 6, it is characterized in that: described Sample assemblies and reagent assembly include swivel base, application of sample block and some sample inserted blocks, chute and sliding part is provided with in described application of sample block, described sample inserted block is placed on application of sample block, and can move on swivel base along chute direction under the effect of sliding part.

8. automatic lmunoassays analyzer as claimed in claim 7, is characterized in that: described suction sample assembly lower end is provided with the unidirectional force (forcing) pump that be connected pneumatic with it, and it is for controlling the adsorbance of inhaling sample assembly.

9. automatic lmunoassays analyzer as claimed in claim 8, it is characterized in that: described reagent assembly also comprises lid, described lid is placed in the periphery of swivel base.