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CN104399129B - 一种制备人工关节用材料及其制备方法 - Google Patents

一种制备人工关节用材料及其制备方法 Download PDF

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CN104399129B
CN104399129B CN201410626137.8A CN201410626137A CN104399129B CN 104399129 B CN104399129 B CN 104399129B CN 201410626137 A CN201410626137 A CN 201410626137A CN 104399129 B CN104399129 B CN 104399129B
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joint prosthesis
silicon rubber
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collagen
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CN104399129A (zh
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涂敏
梁军
周峰
王开秀
李玲玲
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Jingmen Second Peoples Hospital
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Priority to CN201610259463.9A priority patent/CN105802232B/zh
Priority to CN201610262347.2A priority patent/CN105854086B/zh
Priority to CN201610259318.0A priority patent/CN105749344B/zh
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Abstract

本发明提供一种制备人工关节用材料及其制备方法，该材料包括按照质量份数计的如下原料：硅橡胶40～60份，胶原蛋白10～20份，乙烯基硅油1.5～4份，气象法白炭黑20～32份，氢氧化钙0.8～3份。本发明提供的材料具有优异的生物活性、生物相容性和骨传导性，均优于医用钛及硅橡胶，并且其强度高、机械性能好。

Description

一种制备人工关节用材料及其制备方法
技术领域
本发明涉及医学用品领域，尤其涉及一种制备人工关节用材料及其制备方法。
背景技术
人工关节是人们为挽救已失去功能的关节而设计的一种人工器官，它在人工器官中属于疗效最好的一种。一般来说，其使用年限可达20年以上。随着科技进步，人工关节手术已经是一种十分成功和有把握的手术：它可以即刻消除关节疼痛、恢复关节的正常活动功能，使长期受关节病痛折磨的人们再次获得新生，手术后可以象正常人那样，行走、爬楼、外出旅行、外出工作、购物和体育锻炼等。
人工关节的金属部件曾采用不锈钢来制做，后来又发展了钴合金材料，钴合金的耐腐蚀性、耐磨性和机械性能都较好。近来又发展了钛及钛合金材料，含钛材料不但耐腐蚀，而且比重小，更易与人自体的骨长在一起，是理想的材料。人工关节金属部件之间一般都垫有高密度超高分子量聚乙烯塑料。
多年来人们就采用各种人工关节治疗关节强直、关节畸形和各种破坏性骨关节疾病，力图将这些有病的关节矫正，并恢复功能，使之成为稳定的、不疼的，并有一定的功能的关节。为此许多学者做出了巨大的努力。迄今已研制出膝、髋、肘、肩、指、趾关节假体，用于临床。
我国每年20万例的人工关节置换手术。近20年来，我国关节疾病的发病人数不断攀升，其中老年性骨关节炎是发病最多的一种关节疾病。目前我国60岁以上老人中，有55%的人患有骨关节炎，全国约有1.2亿人患有此病。关节置换数量每年以超过30%的速度增加。我国有骨性关节炎的人数占总人口的3%、类风湿患者占0.3%、强直患者约占0.3%，这几千万人虽然不一定都要做手术，但需要做手术的人数最少是实施手术人数的10倍以上。也就是需要做人工关节的人数在200万以上，按每例人工关节材料费4-6万计算，市场理想需求在800亿以上，但是目前需要做手术并且实施手术的比例大约占10%-20%。也就是目前市场规模大约是80亿到160亿，随着生活提高和医改深入，医疗条件改善，目前我国人工关节置换手术增速是30%。
目前市场上现有的制备人工关节用材料本身脆度高、抗折强度低，并且不具有良好的生物活性和生物相容性。
发明内容
解决的技术问题：针对现有的制备人工关节用材料存在的缺点，本发明提供一种制备人工关节用材料及其制备方法，该材料具有优异的生物活性、生物相容性和骨传导性，并且其强度高、机械性能好。
技术方案：一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶40～60份，胶原蛋白10～20份，乙烯基硅油1.5～4份，气相法白炭黑20～32份，氢氧化钙0.8～3份。
上述所述的一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶45～55份，胶原蛋白12～18份，乙烯基硅油2～3份，气相法白炭黑24～30份，氢氧化钙1.3～2.3份。
上述所述的一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶48份，胶原蛋白14份，乙烯基硅油2.2份，气相法白炭黑25份，氢氧化钙1.5份。
上述所述的一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶50份，胶原蛋白15份，乙烯基硅油2.5份，气相法白炭黑27份，氢氧化钙1.8份。
上述所述的一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10～20min，在温度为180～200℃下挤出，即得制备人工关节用材料。
上述所述的熔融共混15min，在温度为190℃下挤出。
有益效果：与现有技术相比，本发明提供的一种制备人工关节用材料及其制备方法，该材料具有优异的生物活性、生物相容性和骨传导性，均优于医用钛及硅橡胶，并且其强度高、机械性能好。
具体实施方式
实施例 1
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶40份，胶原蛋白10份，乙烯基硅油1.5份，气相法白炭黑20份，氢氧化钙0.8份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10min，在温度为180℃下挤出，即得制备人工关节用材料。
实施例 2
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶60份，胶原蛋白20份，乙烯基硅油4份，气相法白炭黑32份，氢氧化钙3份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混20min，在温度为200℃下挤出，即得制备人工关节用材料。
实施例 3
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶45份，胶原蛋白12份，乙烯基硅油2份，气相法白炭黑24份，氢氧化钙1.3份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10min，在温度为180℃下挤出，即得制备人工关节用材料。
实施例 4
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶55份，胶原蛋白18份，乙烯基硅油3份，气相法白炭黑30份，氢氧化钙2.3份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混20min，在温度为200℃下挤出，即得制备人工关节用材料。
实施例 5
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶52份，胶原蛋白17份，乙烯基硅油2.8份，气相法白炭黑28份，氢氧化钙2份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混20min，在温度为200℃下挤出，即得制备人工关节用材料。
实施例 6
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶48份，胶原蛋白14份，乙烯基硅油2.2份，气相法白炭黑25份，氢氧化钙1.5份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混15min，在温度为190℃下挤出，即得制备人工关节用材料。
实施例 7
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶50份，胶原蛋白15份，乙烯基硅油2.5份，气相法白炭黑27份，氢氧化钙1.8份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混15min，在温度为190℃下挤出，即得制备人工关节用材料。
性能测试
对本发明实施例1~7产品的性能进行测试，测试结果见表1。
表1产品性能测试数据
以上对本发明进行了详细介绍，对于本领域的一般技术人员，依据本发明实施例的思想，在具体实施方式及应用范围上均会有改变之处，综上所述，本说明书内容不应理解为对本发明的限制。

Claims (6)

1.一种制备人工关节用材料，其特征在于包括按照质量份数计的如下原料：硅橡胶40～60份，胶原蛋白10～20份，乙烯基硅油1.5～4份，气相法白炭黑20～32份，氢氧化钙0.8～3份。
2.根据权利要求1所述的一种制备人工关节用材料，其特征在于包括按照质量份数计的如下原料：硅橡胶45～55份，胶原蛋白12～18份，乙烯基硅油2～3份，气相法白炭黑24～30份，氢氧化钙1.3～2.3份。
3.根据权利要求1所述的一种制备人工关节用材料，其特征在于包括按照质量份数计的如下原料：硅橡胶48份，胶原蛋白14份，乙烯基硅油2.2份，气相法白炭黑25份，氢氧化钙1.5份。
4.根据权利要求1所述的一种制备人工关节用材料，其特征在于包括按照质量份数计的如下原料：硅橡胶50份，胶原蛋白15份，乙烯基硅油2.5份，气相法白炭黑27份，氢氧化钙1.8份。
5.如权利要求1所述的一种制备人工关节用材料的制备方法，其特征在于包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10～20min，在温度为180～200℃下挤出，即得制备人工关节用材料。
6.根据权利要求5所述的一种制备人工关节用材料的制备方法，其特征在于：所述熔融共混15min，在温度为190℃下挤出。
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798606A (en) * 1985-02-26 1989-01-17 Corvita Corporation Reinforcing structure for cardiovascular graft
CN102363050A (zh) * 2011-06-29 2012-02-29 大连林桥科技有限公司 一种医用生物材料及其制备方法
CN102580583A (zh) * 2012-03-30 2012-07-18 中蓝晨光化工研究设计院有限公司 一种硅橡胶超薄渗透膜的制备方法

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US7258700B2 (en) * 1999-08-18 2007-08-21 Intrinsic Therapeutics, Inc. Devices and method for nucleus pulposus augmentation and retention
CN2565426Y (zh) * 2002-09-05 2003-08-13 上海大学 一种人工关节
EP3146939B1 (en) * 2006-02-07 2018-09-05 Spinalcyte, LLC Composition for repair of cartilage using an in vivo bioreactor
CN101195045A (zh) * 2006-12-07 2008-06-11 曾维桥 生物陶瓷和硅橡胶复合的生物医用材料
ES2687765T3 (es) * 2011-10-21 2018-10-29 Nitta Casings Inc. Materiales de colágeno-polisacárido que imitan los vasos sanguíneos, los tejidos y los huesos
CN103815989B (zh) * 2012-11-19 2015-12-23 苏芳庆 拇指腕掌关节人工植体
CN103627175B (zh) * 2013-12-11 2016-03-02 武汉大学 一种亲水型室温硫化硅橡胶

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798606A (en) * 1985-02-26 1989-01-17 Corvita Corporation Reinforcing structure for cardiovascular graft
CN102363050A (zh) * 2011-06-29 2012-02-29 大连林桥科技有限公司 一种医用生物材料及其制备方法
CN102580583A (zh) * 2012-03-30 2012-07-18 中蓝晨光化工研究设计院有限公司 一种硅橡胶超薄渗透膜的制备方法

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