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CN104398794A - Chinese herbal preparation for maintaining red blood cells - Google Patents

Chinese herbal preparation for maintaining red blood cells Download PDF

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Publication number
CN104398794A
CN104398794A CN201410595282.4A CN201410595282A CN104398794A CN 104398794 A CN104398794 A CN 104398794A CN 201410595282 A CN201410595282 A CN 201410595282A CN 104398794 A CN104398794 A CN 104398794A
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extract
parts
radix
ethanol
extractives
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张坤镛
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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Abstract

The invention discloses a Chinese herbal preparation for maintaining red blood cells, and belongs to the technical field of traditional Chinese medicine technologies. The Chinese herbal preparation comprises, by weight, 10-18 parts of cassia twig extractives, 10-20 parts of radix clematidis extractives, 15-25 parts of caulis spatholobi extractives, 20-30 parts of radix rehmanniae extractives, 10-18 parts of angelica sinensis extractives, 15-25 parts of rhizoma polygonati extractives, 10-18 parts of schisandra chinensis extractives, 10-18 parts of spina date seed extractives, 15-25 parts of hawthorn extractives, 12-20 parts of poria cocos extractives, 5-15 parts of red ginseng extractives, 25-35 parts of astragalus extractives, 12-25 parts of medicated leaven extractives, 20-30 parts of rhodiola rosea extractives and 10-20 parts of horny goat weed extractives. According to the Chinese herbal preparation for maintaining the red blood cells, effective constituents in the traditional Chinese medicines are applied to a composition for maintaining the red blood cells in a matched mode, and the aims of maintaining the red blood cells and recovering the health of the human body are achieved through reasonable proportion matching.

Description

The erythrocytic Chinese medicine preparation of a kind of maintenance
Technical field
The invention discloses a kind of Chinese medicine preparation, belong to technical field of Chinese medicines, specifically the erythrocytic Chinese medicine preparation of a kind of maintenance.
Background technology
Erythrocyte also claims erythrocyte, is a kind of hemocyte that in blood, quantity is maximum, and ripe mammalian erythropoietin does not have nucleus and mitochondrion, is rich in hemoglobin.Rely on glucose synthesis energy, average diameter is 9 microns.Erythrocytic Main Function is the topmost medium transporting oxygen in vertebrate.Erythrocyte to each position of person tissue, then transports out metabolite carbon dioxide from each position, so erythrocyte is indispensable in our human body " transport team " oxygen transportation.Containing hemoglobin in erythrocyte, blood is thus made to take on a red color.Hemoglobin can and air in oxygen combination, therefore the oxygen sucked in alveolar transports to tissue by hemoglobin by erythrocyte, and a part of carbon dioxide that in tissue, metabolism produces also is transported to pulmonary by alveolar by erythrocyte and carried out gas exchange with external oxygen, carbon dioxide is excreted.Except transports oxygen, erythrocyte also has other important function.
Such as phagocytosis: erythrocyte also has the function of phagocyte sample, has peroxidase at its surface of cell membrane, and this enzyme is typical lysosomal enzyme, and it can play the lethal effect of macrophage-like.
Immune adherence effect: after immune adherence refers to that antigen-antibody complex is combined with Complement C_3 b, in the erythrocyte that can adhere to Primates or non-Primates and platelet, this phenomenon is referred to as " blood cell immunity adhesive attraction ".Why erythrocyte has immune adherence effect, is because its surface has C3b receptor.This receptor is glycoprotein, and molecular weight is 205000D.C3b receptor on erythrocyte accounts for more than 95% of C3b receptor sum in blood circulation.Therefore, the antigen-antibody complex in blood circulation runs into erythrocyte than running into leukocytic chance many 500 ~ 1000 times.So it is less than leukocyte and lymphocyte that erythrocyte removes the characteristic of immune complex.
Defence is infected: after erythrocyte and the microorganism such as antibacterial, virus immune adherence, not only can produce direct lethal effect by peroxidase to them, but also can promote that phagocyte is to their phagocytosis.Therefore, erythrocytic immunologic function can be regarded as one of factor of body anti-infectious immunity.
Erythrocyte is essential to maintenance human normal health, erythrocytic quantity, feature is also the important indicator of human body physiological status, and many human body diseases are hereditary hematologic disease such as, anemia disease, toxic symptom etc. all has inseparable relation with erythrocyte, therefore maintaining the normal physiological activity of erythrocyte, is also the key of disease therapy.The erythrocytic Chinese medicine preparation of a kind of maintenance provided by the invention, but the cooperation of effective Chinese medicine ingredients of the Chinese medicine derived from integration of edible and medicinal herbs catalogue disclosed in health ministry is applied in the erythrocytic compositions of maintenance, coordinated by rational ratio, reach maintenance erythrocyte, make the restorative object of human body.
Summary of the invention
The present invention, according to the research of modern Chinese medicine effective ingredient and traditional tcm theory, provides a kind of maintenance erythrocytic Chinese medicine preparation, and the effective elements of the medicine preparation in directly using, therapeutic effect fast and significantly.The raw material Chinese medicine of concrete application is as follows:
Ramulus Cinnamomi: [nature and flavor] are pungent; Sweet; [return through] warm in nature bladder; The heart; Lung meridian [function cures mainly] expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.[chemical analysis] Ramulus Cinnamomi is containing volatile oil 0.69%, in oil, main component is cinnamic aldehyde (cinnamaldehyde) 64.75%, also has benzyl benzoate (benzylbenzoate), cinnamyl acetate (cinnamylacetate), β-cadinene (β-cadinene), Chang Pu alkene (calamenene), coumarin (coumarin) etc.[pharmacological action] 1. antibacterial action.2. antivirus action.3. diuresis.
Radix Clematidis: [nature and flavor] are pungent, salty, temperature.[return through] returns urinary bladder channel.[function cures mainly] expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx.The root of [chemical analysis] 1. Radix Clematidis is containing Anemonin, anemonol, sterol, saccharide, Saponin, lactone, phenols, aminoacid.Leaf is containing lactone, phenols, triterpene, aminoacid, organic acid.2. the leaf of mountain knotweed is containing flavonoid 0.23% and alkaloid, volatile oil, resins etc. such as Coumarins 0.82%, nimbecetins, not containing Saponin, tannin or Cardiac glycosides.3. the root of northeast clematis is containing triterpenoid saponin: clematitol A, clematitol A ', clematitol B, clematitol C.4. the root of Rhizoma Dioscoreae Bulbiferae and mutation thereof is containing Saponin, hederagenin.[pharmacological action] is 1. to the effect of blood circulation.2. on the impact of smooth muscle.3. antidiuretic activity.4. hypoglycemic activity.
Caulis Spatholobi [meridian distribution of property and flavor]: bitter, sweet, temperature.Return liver, kidney channel.[ function cures mainly] enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.[chemical composition] this product is containing formoononetin, ononin, prunusetin., A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol, 3,7-dihydroxy-6-melonia flavonol, epicatechin, protocatechuic acid, freidelin-3b-alcohol, b-sitosterol, daucosterol and 7-ketone group-b-sitosterol.[pharmacological action] 1. vasodilative effect: Caulis Spatholobi Aqueous extracts precipitate with ethanol preparation 20mg/kg directly injects femoral artery, injecting femoral artery blood flow in latter 10 minutes increases by 42.7%; During peak value, value added reaches 133%; Vascular resistance reduces 45.3%.2. antiplatelet aggregative activity: Caulis Spatholobi crude drug water decoction-alcohol sedimentation preparation is when 100mg/kg concentration, obvious inhibitory action .3. is had on the impact of experimental arthritis in vitro: Caulis Spatholobi tincture is to rat oral gavage, and PARA FORMALDEHYDE PRILLS(91,95) arthritis has significant curative effect on the rat platelet aggregation of two phosphorus adenosine inductions.
Radix Rehmanniae Preparata [nature and flavor] is sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.[chemical analysis] Radix Rehmanniae Preparata is containing the cyclenes ether circle constituents of small amount, send out from obtaining: Herba Leonuri glycoside (leonuride), aucubin (aucubin), catalpol (catalpol), rehmannioside (rehmannioside) A, B, C, D, U.S. profit appropriate pair of glycoside (melit-toside), rehmanin (tehmaglutin) A, D, the smelly formaldehyde glycoside (gluti-noside) of Radix Rehmanniae chlorination etc.Again containing monoterpene composition: burnt rehmanin (jioglutin) A, B, C, burnt Radix Rehmanniae lactone (jioglutolide), burnt jiofuran (jiolutin) A, B, C, burnt Radix Rehmanniae lactone (jioglutolide), burnt jiofuran (jiofuran), the bitter glycoside unit (rehmapicrogenin) of Radix Rehmanniae etc.Again containing aminoacid, its composition compares with Radix Rehmanniae, does not contain lysine (lysine) and all corresponding deceleration of content is few.Also containing saccharide, wherein the content of monosaccharide is than more than twices many in Radix Rehmanniae.Another containing trihydroxy-alpha, beta-lonone (TCMLIBihy-droxy-β-ionone), 5-hydroxyl aeginetic acid (5-c-hydroxyaegineticacid), succinic acid (suscinicacid), 5-pidolic acid (5-oxoproline), 5-HMFA (5-hydroxymethylfuroicacid), uracil), uracil (uracil), uridine (uridine) etc.Be separated from ligroin extraction again and obtain: industry oleic acid (linoleicacid), Palmic acid (palmiticacid), stearic acid (stearicacid), arachidic acid (arachidicacid) behenic acid (behenicacid), pentadecanoic acid (pentadecanoicacid), palmitoleic acid (palmitoleicacid), interior myristic acid (myristicacid), 19 carbonic acid (nonade-canoicacid), two hendecoic acids (heneicosanoicacid), two or seven carbonic acid (margaricacid) [6].The effect of [pharmacological action] 1. Radix Rehmanniae Preparata slow down aging.2. on the impact of the hyperthyroidism type deficiency of YIN.3. Radix Rehmanniae Preparata blood tonification effect.4. anastalsis after Radix Rehmanniae Preparata parch to black.
Radix Angelicae Sinensis [nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.[chemical analysis] root is containing volatile oil, and Minxian County, Gansu product person contains 0.7% containing 0.4%, Si Chuanwen county product person.Volatilization main body of oil has: butylidenephthalide, the positive pentanone of adjacent carboxyl benzene and Δ 2,4-dihydro acid phthalic anhydride.Volatile oil component is complicated, is singly that low boiling part just has kind more than 10, wherein has multiple hydro carbons, comprise 3 kinds of terpenes.Another containing volume sucrose (40%), vitamin B12 (0.25 ~ 40 microgram/100 gram), retinoid material (in vitamin A, being 0.0675% containing rate).Containing Palmic acid, stearic acid, myristic acid and unsaturated oleic acid, sub-kojic acid in the saponification part of root; Cupreol is had in not saponification composition.Herb has fragrance, and known each several part all contains volatile oil, and fruit content spy is many.The effect of [pharmacological action] 1. pair uterine smooth muscle.2. the effect of pair cardiovascular system.3. pair blood and cardiovascular system.4. promote cell function restitution.5 immunizations.6. antiinflammatory action.7 antitumaous effects.8. antibacterial action.9. except free radical.10. anti-ageing anti-old.
Rhizoma Polygonati [nature and flavor] is sweet, flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.The mucous matter of rhizome of [chemical analysis] Rhizoma Polygonati, starch and sugar.The rhizome of P. cyrtonema is containing azetidinecarboxylic acid, aspartic acid, homoserine, DAB, digitalis glucoside and multiple intelligent quinones.Leaf contains vitexin xyloside and 5, the glucoside of 4 '-dihydroxyflavone.[pharmacological action] 1. antibacterial action.2. antifungic action.3. hypotensive effect.
Fructus Schisandrae Chinensis [nature and flavor] is sour, sweet, temperature.[return through] returns lung, the heart, kidney channel.[function cures mainly] restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.[chemical analysis] 1. fruit of Fructus Schisandrae Chinensis contains multiple lignanoid: Ge meter Xin (gomisin) A, gomisin B and schisandra chinensis ester (schisantherin) B, gomisin C and schisandra chinensis ester (schisantherin) A, Gomisin F., G, schizandrin (schisandrin) i.e. wuweizi alcohol A (wuweizichunA, schisandrolA), Gomisin D., Gomisin H., Radix Angelicae Sinensis acyl Ge meter Xin (angeloylgomisin) H, crotonocyl Ge meter Xin (tigloylgomisin) H, benzoic acid Ge meter Xin (benzoylgomisin) H, GJ, front Ge meter Xin (pregomisin), meso-dihydroguaiaretic acid (mexo-dihydroguaiareticacid), Biao Ge meter Xin (epigomisin) O, dextrorotation-deoxyschisandrin (deoxy-schisandrin) i.e. wuweizisu A, GN, O, E, dimethyl Ge meter Xin (dimethylgomisin) J, Gomisin P., remove Radix Angelicae Sinensis acyl Ge meter Xin (deangeloylgomisin), left-handed-gomisin K 1, dextrorotation-gomisin K 2, K3, tigloylgomisin P, angelic acid Gomisin P., Radix Angelicae Sinensis acyl Ge meter Xin Q, right trip-gomisin M2, raceme-gomisin M 1, wuweizisu B and wuweizisu B, left trip-gomisin L 1, L2, Radix Angelicae Sinensis acyl Gomisin O., the different Ge meter Xin of angelic acid (angeloylisogomisin) O, the different Gomisin O. of benzoyl (benzoylisogomisin) O, Ge meter Xin R, schisandrin C, Ge meter Xin S, T [3], isoschizandrin (isoschisandrin) and nor-dihydroguaiaretic acid (nordihydroguaiareticacid) etc., also containing volatile oil, its composition has α-thujene (α-thujene), α-and nopinene (pinene), lauro lene (camphene), α-phellandrene (α-phellandrene), β-terpinene (β-terpinene), 4-terpinenol (terpinen-4-ol), α-terpinenol (α-terpineol), α-(king is ancient) (king's bar) alkene (α-copaene), beta-elemene (β-elemene), acoradiene (acoradiene), α-and β-cedrene (himachalene), nerolidol (nerolidol), furfural (furaldehyde), methyln nonyl ketone (2-undecanone and p-isopropyl acid (p-isopropylbenacid) etc. 32 kinds.Kernel contains wuweizisu A, B, C, wuweizi alcohol A and wuweizi alcohol B.The effect of [pharmacological action] 1. couple central nervous system.2. the protective effect of pair liver.3. the effect of pair digestive system.4. the effect of pair cardiovascular system.5. on the impact of respiratory system.6. the effect of pair function of immune system.7. the effect of slow down aging.8. anti-allergic effects.
Semen Ziziphi Spinosae [nature and flavor] is sweet, sour, flat.[return through] returns liver, gallbladder, heart channel.[function cures mainly] tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.[chemical analysis] containing volume fatty oil and protein, and has two kinds of sterols: a kind of is C26H42O2, and fusing point 288 ~ 290 DEG C, is soluble in alcohol; Alternative fusing point is 259 ~ 260 DEG C, is soluble in chloroform.Call again this product master containing two kinds of triterpenoids: betulin, betulic acid.Another containing jujuboside, glycoside unit is jujubogenin, is hydrolyzed the second step product that the Ebelin Lactone obtained is Saponin.Also containing volume vitamin C.[pharmacological action] be calm, syngignoscism 1..2. analgesia, convulsion, cooling effect.3. on the impact of cardiovascular system.4. on the impact of burn, Semen Ziziphi Spinosae is alone or share with Fructus Schisandrae Chinensis, all can improve the survival rate of scalding.5. excitation is had to uterus.
Fructus Crataegi [nature and flavor] is sour, sweet, tepor.[return through] returns spleen, stomach, Liver Channel.[function cures mainly] promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.[chemical analysis] is containing epicatechin [(-)-epicatechin], Quercetin (quercetin), hyperin (hyperin), chlorogenic acid (chlorogenicacid), Crataegolic acid (crataegolicacid), citric acid (citricacid), amygdalin (amygdalin) etc.[pharmacological action] 1. facilitating digestion effect.2. the effect (1) of pair cardiovascular system makes to strengthen at body, Isolated Toad contractile force to action of the heart crataegus pin natifida var. Major extract, and the persistent period is long.(2) hypotensive effect experiment proves, crataegus pin natifida var. Major has more lasting hypotensive effect.3. effect for reducing fat.4. antioxidation.5. protective effect on cancer risk.6. Fructus Crataegi has contraction uterus, promotes uterine involution, analgesic effect.7. sedation.
Poria [nature and flavor] is sweet, light, flat.[return through] GUIXIN, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.[chemical analysis] sclerotium accounts for dry weight 93% and triterpenoid compound Pachymic acid, pachymic acid, 3 beta-hydroxy Pilus Caprae seu Ovis steroid trienic acids containing β-pachyman.In addition, still gummy, chitin, protein, fat, sterol, lecithin, glucose, adenine, histidine, choline, β-pachyman catabolic enzyme, lipase, protease etc.[pharmacological action] 1. diuresis.2. antibacterial action.3. on the impact of digestive system.4. other effects.
Sweet, the micro-hardship of Radix Ginseng Rubra [nature and flavor], temperature.[function cures mainly] relaxing muscles and tendons to promote blood circulation, promoting tissue regeneration by removing blood stasis.Cure mainly traumatic injury, rheumatalgia, hemorrhage due to internal injury, sputum mixed with blood, amenorrhea, menoxenia, leukorrhagia, puerperal, arthralgia, had a sleepless night, and pulmonary tuberculosis is dizzy dizzy.[chemical analysis] root contains anthraquinone glycoside constituents: 2-methyl isophthalic acid, 3, 6-trihydroxy-9, 10-anthraquinone-3-O-(6 '-O-acetyl group)-α-L-rhamanopyranosyl (1 → 2)-β-D-Glucose glycoside [2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone-3-O-(6 '-O-acetyl)-α-L-rhamnosyl (1 → 2)-β-D-glucoside], 2-methyl isophthalic acid, 3, 6-trihydroxy-9, 10-anthraquinone-3-α-L-rhamanopyranosyl) (1 → 2)-β-D-Glucose glycoside [2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone-3-O-α-L-rhamnosyl (1 → 2)-β-D-glucoside], 2-methyl isophthalic acid, 6-dihydroxyanthraquinone-3-O-(6 '-O-acetyl group)-α-L-rhamnopyranosyl (1 → 2)-β-D-Glucopyranose. [2-methyl-1, 6-dihy-droxyanthraquinone-3-O-(6 '-O-acetyl)-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside], 2-methyl isophthalic acid, 6-dihydroxyanthraquinone-3-O-α-L-rhamnopyranosyl (1 → 2)-β-D-glucopyanoside [2-methyl-1, 6-dihydroxyan-thraquinone-3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosi-de], also containing rubia instinct (ruberythricacid), three arbor alkane type triterpenoid (arbo-ranetypetriterpenoid) compositions: Radix Rubiae arbor alcohol (rubiarbonol) A, G, Radix Rubiae arbor ketone (rubiarbonone) A.Another containing a called after ring peptide glycoside (glycocyclohexapeptide) RY-1 and glycoside unit RA-V thereof.
The Radix Astragali [nature and flavor] is sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.[chemical analysis] 1. Radix Astragali root contains 2 ', 4 ' dihydroxy-5, the folic acid of 6-dimethoxy isoflavone (2 ', 4 '-dihydroxy-5,6-dimethoxyisoflavone), choline (choline), betanin (betaine), aminoacid, sucrose, glucuronic acid and trace.2. astragalus mongholicus Bge root is containing cupreol, linoleic acid and linolenic acid.[pharmacological action] 1, normal rat are raised and after 1 week with the affairs containing Radix Astragali powder, are surveyed before its oxygen consumption ratio is taken medicine and increase gradually.2, normal heart can be strengthened shrink, have cardiotonic to the heart of exhaustion.3, this product can make tubular blood vessel and renal blood vessels expansion, and makes whole body peripheral vasodilation, and skin circulation is freely contained, and makes hyperpietic's blood pressure drops.4, experimenter has carried out diuretic test on one's body, proves that the Radix Astragali has medium diuresis.5, the Radix Astragali is clayed into power and is added feedstuff and feed 3 to rat, has the effect preventing Jishengshenqiwan.6, the Radix Astragali has sedation to white mice, can maintain a few hours.7, rabbit oral administration astragalus, can make blood glucose obviously decline.8, to rat isolated uterine, there is excitation-contraction effect.9, bacteriostatic test: this product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.
Massa Medicata Fermentata [nature and flavor] sweet, acrid, warm.[return through] enters spleen, stomach warp.[function cures mainly] invigorating the spleen and regulating the stomach, helps digestion in adjusting.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.1. " property of medicine opinion ": " digesting and absorbing the essence of foodstuff dyspepsia, crux stagnates, spleen invigorating warming the stomach." 2. Zhang Yuansu: " nourishing the stomach gas.Control also white chaste tree." 3. Materia Medica of Decoction: " treats pathogenic wind in internal organs, the therapeutic method to keep the adverse QI flowing downwards in tune, and whet the appetite the dyspepsia that disappears.Main cholera heart diaphragm gas, expectorant is inverse, relieving restlessness, and broken crux and tonify deficiency, remove cold air, fill in except in the intestines and stomach, not lower food.Can control children's's abdomen hard large as dish, fullness in the chest, frequent fetal movement, or lumbago robs the heart, hematochezia is more than." 4. " detailed outline ": " removing stagnancy of indigested food and making QI downward, expectorant lets out dysentery distension against cholera.Sprain lumbago person, forged wine decoction being taken warmly of quenching effective, and married woman's wish in puerperal galactopoiesis person, stir-fry is ground wine and taken two money, day two." 5. " book on Chinese herbal medicine is stated ": " cure the wound summer-heat, and being affected by fluid-retention is eaten, and hinders overstrain, and malaria flatulence due to stagnation of QI is demonstrate,proved, and edema distension gathers, cough due to fluid-retention, and vomiting regurgitation, cholera, blood-retention, pained, gastric abscess, hypochondriac pain, numbness flaccidity is dizzy, heavy sensation of the body, can not eat, jaundice." 6. " book on Chinese herbal medicine is new again ": " scrofula that disappears cellulitis tumor." its composition of [chemical analysis] Massa Medicata Fermentata has volatile oil, glycoside, fatty oil and vitamin B etc.
Radix Rhodiolae [nature and flavor] is sweet, puckery, cold.[function cures mainly] clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.[chemical analysis] 1. Rhodiola sachalinensis root and stem contains butyl alcohol (tyrosol) and salidroside (salidroside), also known as rhodioloside (rhodioloside).2. Radix Rhodiolae root isolates 13 kinds of compositions, through qualification, wherein nine kinds are: caffeic acid (caffeicacid), umbelliferone (umbelliferone), butyl alcohol (tyrosol), gallic acid (gallicacid), progallin A (gallicacidethylester), kaempferol (kaemoferol), cupreol (β-sitosterol), daucosterol (daucosterol) and rhodioloside (rhodioloside).
Herba Epimedii [nature and flavor] acrid, sweet, warm.[return through] returns liver, kidney channel.[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.[chemical analysis] Herba Epimedii stem, leaf are containing icariine, and leaf is still containing volatile oil, ceryl alcohol, 1 alkane, plant sterol, tannin, oils and fats.Fatty acid in fatty oil has Palmic acid, stearic acid, oleic acid, linoleic acid.[pharmacological action] is 1. on the impact of sexual function.2. to bacteriostasis.3. antitussive, eliminate the phlegm and antiasthmatic effect.4. other effects.Extraction ofHerba Epimedii has hypotensive effect to rabbit, in a small amount the secretion of urine is increased, then suppresses it on the contrary in a large number, have inhibitory action to isolated rabbit intestinal, and isolated uterine is first excited rear suppression then, and the oral hyperglycemic rat blood glucose that can make declines, containing vitamin E in Herba Epimedii.
Above Chinese medicine background knowledge comes from " Chinese medicine voluminous dictionary " corresponding chapters and sections, is as the criterion with " Chinese medicine voluminous dictionary " record if any few words mistake.
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 10-18 part, Radix Clematidis extract 10-20 part, Caulis Spatholobi extract 15-25 part, Radix Rehmanniae Preparata extract 20-30 part, Radix Angelicae Sinensis extract 10-18 part, Rhizoma Polygonati extract 15-25 part, Fructus Schisandrae Chinensis extrat 10-18 part, Semen Ziziphi Spinosae extract 10-18 part, Fructus Crataegi extract 15-25 part, Poria extract 12-20 part, Radix Ginseng Rubra extract 5-15 part, Radix Astragali extract 25-35 part, Massa Medicata Fermentata extract 12-25 part, Radix Rhodiolae extract 20-30 part, Herba Epimedii extract 10-20 part;
Wherein Ramulus Cinnamomi extract: the ethanol being 95% by the weight percent concentration adding Ramulus Cinnamomi weight 15 times in Ramulus Cinnamomi carries out ultrasonic assistant extraction, Extracting temperature is 50 DEG C, and extraction time is 2 ~ 3 hours, and supersonic frequency is 30 ~ 40 KHz; Filtering and concentrating, crosses 80 mesh sieves and get final product after concentrated solution vacuum drying;
Radix Clematidis extract: clematis chinensis medicinal materials adopts the alcoholic solution heating and refluxing extraction 60min of 85% concentration of 8 times of volumes; Extracting solution is concentrated, after removing ethanol, centrifuging and taking supernatant is diluted to 0.2kg/L; Adopt n-butanol extraction; After n-butanol portion is concentrated, be separated with DA-201 type macroporous resin; Ethanol gradient elution, collects eluent, concentrating under reduced pressure; Cross 80 mesh sieves after concentrated solution vacuum drying and get final product;
Caulis Spatholobi extract: by Caulis Spatholobi pulverizing medicinal materials, adds the ethanol of 50%, reflux, extract, 3 times, each 2 hours, and extracting solution is concentrated into without alcohol taste by merge extractive liquid; Extracting solution macroporous adsorptive resins is adsorbed; First time washes with water to sugar-free reaction, and the second time ethanol elution of 30% obviously shoals to color, and the ethanol elution of third time 70% obviously shoals to color; Collect ethanol elution, reclaim ethanol, vacuum concentration drying rear mistake 80 mesh sieve obtains Caulis Spatholobi extract;
Radix Rehmanniae Preparata extract: by the coarse crushing of Radix Rehmanniae Preparata dry product, with 95% ethanol of 7 times of volumes to coarse crushing thing reflux, extract, 4 hours, then extract 2.5 hours at 95 DEG C by 6 times of water yields, filter centrifugation, with ethanol precipitate with ethanol 4 hours sucking filtration of 95% after supernatant concentration, vacuum concentration drying rear mistake 80 mesh sieve and get final product;
Radix Angelicae Sinensis extract: by Radix Angelicae Sinensis coarse crushing, adds dehydrated alcohol at extraction temperature 40-45 DEG C, extracting pressure 28-32MPa, resolves pressure 9-12 MPa, CO 2carry out extraction 8 hours under the condition of flow 10-12L/h, reclaim ethanol, vacuum concentration drying rear mistake 80 mesh sieve and get final product;
Rhizoma Polygonati extract: by Rhizoma Polygonati coarse crushing, adopts water extraction to extract, adds activated carbon decolorizing, filter to obtain extracting solution, concentrated, uses 95% alcohol settling, spends the night, and centrifugal, reclaim ethanol, namely vacuum concentration drying rear mistake 80 mesh sieve obtains Rhizoma Polygonati extract;
Fructus Schisandrae Chinensis extrat: by the hot-water soak of Radix Schisandrae Bicoloris with 65 DEG C, removing peel, is ground into coarse powder after oven dry, and volatile oil is removed in distillation; Be temperature 50 C at extraction conditions in above-mentioned Fructus Schisandrae Chinensis, extract 4 times under passing into the butane of volumetric concentration 80%, it is 2 hours at every turn, merge extractive liquid, extracting solution, under 40 DEG C of conditions, leaves standstill layering after 18 hours, gets upper liquid and concentrates, the ethanol of volumetric concentration 80% is added, centrifuging and taking supernatant in concentrated solution; Adsorb supernatant by non-polar macroporous resin, with the organic solvent eluting 3 times of volumetric concentration 70%, reclaim organic solvent, cross 80 mesh sieves after vacuum drying is concentrated and namely obtain Fructus Schisandrae Chinensis extrat;
Semen Ziziphi Spinosae extract: Semen Ziziphi Spinosae is pulverized, fatty oil in squeezing Semen Ziziphi Spinosae, the Semen Ziziphi Spinosae medicinal residues squeezing fatty oil add the soak by water 3 times of 6 times amount, each 1.5 hours, merge each filtrate after filtering, filtrate added 95% ethanol after being condensed into thick paste, thick paste alcohol content is made to reach 60 ~ 80%, hold over night, concentrated after filtering, cross 80 mesh sieves after vacuum drying and namely obtain Semen Ziziphi Spinosae extract;
Fructus Crataegi extract: Fructus Crataegi is soaked 1-2h, decocts with water 3 times, decocts 2h at every turn, filters, obtains filtrate and filtering residue; By filtering residue with 85% alcohol heating reflux extract 2 times, merge extractive liquid, and above-mentioned filtrate are first extract; By first extract macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, namely mistake 80 mesh sieves obtain Fructus Crataegi extract;
Poria extract: Poria was pulverized 100 mesh sieves, the alcohol heating reflux with 85% extracts 3 times, merge extractive liquid, by macroporous resin adsorption and with 60% ethanol to low pole macroporous resin column eluting 3 times, reclaim ethanol, concentrated, cross 80 mesh sieves after vacuum drying and namely obtain Poria extract;
Radix Ginseng Rubra extract: add 8 times amount water soaking after being shredded by Radix Ginseng Rubra 2 hours, heating and refluxing extraction 2 hours, extracts 3 times, merge extractive liquid, filters, concentrated; Concentrated solution is used reverse phase silica gel column separating purification; Methanol-eluted fractions with 60% 3 times, each consumption 5L, collects eluent, concentrated, crosses 80 mesh sieves and obtain Radix Ginseng Rubra extract after vacuum drying;
Radix Astragali extract: the Radix Astragali is soaked 2h, decocts with water 2 times, decocts 2h at every turn, filters, obtains filtrate and filtering residue; By filtering residue with 85% alcohol heating reflux extract 2 times, merge extractive liquid, and above-mentioned filtrate are first extract; By first extract macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, namely mistake 80 mesh sieves obtain Radix Astragali extract;
Massa Medicata Fermentata extract: by Massa Medicata Fermentata coarse crushing, by the alcohol heating reflux lixiviate of 10 times of volumes 75%, temperature 90 DEG C, extract 2 times, time 3h, obtains crude extract; Crude extract is carried out rapid filtration under suction, crosses 80 mesh sieves after filter vacuum concentrate drying and obtain Massa Medicata Fermentata extract;
Radix Rhodiolae extract: by Radix Rhodiolae pulverizing medicinal materials, soaks 2 hours; Soaked Radix Rhodiolae is added water and uses ultrasonic assistant extraction method, extract 3 times, filter after merge extractive liquid, and obtain filtrate; By filtrate by D101 macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, mistake 80 mesh sieves obtain Radix Rhodiolae extract;
Herba Epimedii extract: pulverized by epimedium herb, the alcohol reflux with 75% 3 hours, extraction time is 3 times; Above-mentioned filtrate is merged sucking filtration, and concentrating under reduced pressure reclaims ethanol and obtains just extract, then with 95% ethanol, purified water flushing reuse; By the extraction of above-mentioned just extract, standing, sucking filtration, obtain crude extract; Above-mentioned crude extract macroporous resin column adsorbed, then use the ethanol of 50-60% to macroporous resin column eluting, eluted product reclaims eluent, and namely vacuum concentration drying rear mistake 80 mesh sieve obtains Herba Epimedii extract.
The described erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 11-17 part, Radix Clematidis extract 11-19 part, Caulis Spatholobi extract 16-24 part, Radix Rehmanniae Preparata extract 21-29 part, Radix Angelicae Sinensis extract 11-17 part, Rhizoma Polygonati extract 16-24 part, Fructus Schisandrae Chinensis extrat 11-17 part, Semen Ziziphi Spinosae extract 11-17 part, Fructus Crataegi extract 16-24 part, Poria extract 13-19 part, Radix Ginseng Rubra extract 6-14 part, Radix Astragali extract 26-34 part, Massa Medicata Fermentata extract 13-24 part, Radix Rhodiolae extract 21-29 part, Herba Epimedii extract 11-19 part.
The described erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 12-16 part, Radix Clematidis extract 12-18 part, Caulis Spatholobi extract 17-23 part, Radix Rehmanniae Preparata extract 22-28 part, Radix Angelicae Sinensis extract 12-16 part, Rhizoma Polygonati extract 17-23 part, Fructus Schisandrae Chinensis extrat 12-16 part, Semen Ziziphi Spinosae extract 12-16 part, Fructus Crataegi extract 17-23 part, Poria extract 14-18 part, Radix Ginseng Rubra extract 7-13 part, Radix Astragali extract 27-33 part, Massa Medicata Fermentata extract 14-23 part, Radix Rhodiolae extract 22-28 part, Herba Epimedii extract 13-17 part.
The described erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 14 parts, Radix Clematidis extract 16 parts, Caulis Spatholobi extract 19 parts, Radix Rehmanniae Preparata extract 25 parts, Radix Angelicae Sinensis extract 14 parts, Rhizoma Polygonati extract 20 parts, Fructus Schisandrae Chinensis extrat 15 parts, Semen Ziziphi Spinosae extract 13 parts, Fructus Crataegi extract 20 parts, Poria extract 17 parts, Radix Ginseng Rubra extract 10 parts, Radix Astragali extract 29 parts, Massa Medicata Fermentata extract 15 parts, Radix Rhodiolae extract 26 parts, Herba Epimedii extract 15 parts.
The described erythrocytic Chinese medicine preparation of a kind of maintenance, be using the extract of described crude drug proportionally fill enter capsule or directly as oral powder.
Usefulness of the present invention is: the present invention is different from the monarch prescription of the Chinese medicine of succession, required Effective Component of Chinese Medicine directly applies in Chinese medicine preparation, play better curative effect, clothes for patients is facilitated to absorb, remove the trouble preparing Chinese medicine from, wherein Radix Angelicae Sinensis, Caulis Spatholobi, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Schisandrae Chinensis in Chinese medicine preparation, the extract replenishing blood for nourishing heart of Radix Rhodiolae; The Radix Astragali, Radix Ginseng Rubra, Poria, Massa Medicata Fermentata extract air making-up and spleen enlivening to take the photograph blood, Radix Clematidis extract expelling wind and removing dampness, removing obstruction in the collateral to relieve pain; Ramulus Cinnamomi, Semen Ziziphi Spinosae, the extract yin nourishing YANG hyperactivity suppressing of Herba Epimedii is with sleeping; Fructus Crataegi extract stops blooding; Coordinated under the synergism of wherein terpene compound, flavone compound, polyphenol compound etc., reaches the effect to erythrocyte maintenance, thus plays positive facilitation to the treatment of disease.
Accompanying drawing explanation
Fig. 1 is erythrocyte photo under the Electronic Speculum before case 1 patient takes Chinese medicine preparation of the present invention;
Fig. 2 is erythrocyte photo under the Electronic Speculum before case 2 patient takes Chinese medicine preparation of the present invention;
Fig. 3 is erythrocyte photo under the Electronic Speculum before case 3 patient takes Chinese medicine preparation of the present invention;
Fig. 4 is erythrocyte photo under the Electronic Speculum before case 4 patient takes Chinese medicine preparation of the present invention;
Fig. 5 is erythrocyte photo under the Electronic Speculum before case 5 patient takes Chinese medicine preparation of the present invention;
Fig. 6 is erythrocyte photo under the Electronic Speculum before case 6 patient takes Chinese medicine preparation of the present invention;
Fig. 7 is erythrocyte photo under the Electronic Speculum before case 7 patient takes Chinese medicine preparation of the present invention;
Fig. 8 is photo under the erythrocytic Electronic Speculum of normal human.
Detailed description of the invention
Embodiment 1
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 10 parts, Radix Clematidis extract 10 parts, Caulis Spatholobi extract 15 parts, Radix Rehmanniae Preparata extract 20 parts, Radix Angelicae Sinensis extract 10 parts, Rhizoma Polygonati extract 15 parts, Fructus Schisandrae Chinensis extrat 10 parts, Semen Ziziphi Spinosae extract 10 parts, Fructus Crataegi extract 15 parts, Poria extract 12 parts, Radix Ginseng Rubra extract 5 parts, Radix Astragali extract 25 parts, Massa Medicata Fermentata extract 12 parts, Radix Rhodiolae extract 20 parts, Herba Epimedii extract 10 parts;
Wherein Ramulus Cinnamomi extract: the ethanol being 95% by the weight percent concentration adding Ramulus Cinnamomi weight 15 times in Ramulus Cinnamomi carries out ultrasonic assistant extraction, Extracting temperature is 50 DEG C, and extraction time is 2 ~ 3 hours, and supersonic frequency is 30 ~ 40 KHz; Filtering and concentrating, crosses 80 mesh sieves and get final product after concentrated solution vacuum drying;
Radix Clematidis extract: clematis chinensis medicinal materials adopts the alcoholic solution heating and refluxing extraction 60min of 85% concentration of 8 times of volumes; Extracting solution is concentrated, after removing ethanol, centrifuging and taking supernatant is diluted to 0.2kg/L; Adopt n-butanol extraction; After n-butanol portion is concentrated, be separated with DA-201 type macroporous resin; Ethanol gradient elution, collects eluent, concentrating under reduced pressure; Cross 80 mesh sieves after concentrated solution vacuum drying and get final product;
Caulis Spatholobi extract: by Caulis Spatholobi pulverizing medicinal materials, adds the ethanol of 50%, reflux, extract, 3 times, each 2 hours, and extracting solution is concentrated into without alcohol taste by merge extractive liquid; Extracting solution macroporous adsorptive resins is adsorbed; First time washes with water to sugar-free reaction, and the second time ethanol elution of 30% obviously shoals to color, and the ethanol elution of third time 70% obviously shoals to color; Collect ethanol elution, reclaim ethanol, vacuum concentration drying rear mistake 80 mesh sieve obtains Caulis Spatholobi extract;
Radix Rehmanniae Preparata extract: by the coarse crushing of Radix Rehmanniae Preparata dry product, with 95% ethanol of 7 times of volumes to coarse crushing thing reflux, extract, 4 hours, then extract 2.5 hours at 95 DEG C by 6 times of water yields, filter centrifugation, with ethanol precipitate with ethanol 4 hours sucking filtration of 95% after supernatant concentration, vacuum concentration drying rear mistake 80 mesh sieve and get final product;
Radix Angelicae Sinensis extract: by Radix Angelicae Sinensis coarse crushing, adds dehydrated alcohol at extraction temperature 40-45 DEG C, extracting pressure 28-32MPa, resolves pressure 9-12 MPa, CO 2carry out extraction 8 hours under the condition of flow 10-12L/h, reclaim ethanol, vacuum concentration drying rear mistake 80 mesh sieve and get final product;
Rhizoma Polygonati extract: by Rhizoma Polygonati coarse crushing, adopts water extraction to extract, adds activated carbon decolorizing, filter to obtain extracting solution, concentrated, uses 95% alcohol settling, spends the night, and centrifugal, reclaim ethanol, namely vacuum concentration drying rear mistake 80 mesh sieve obtains Rhizoma Polygonati extract;
Fructus Schisandrae Chinensis extrat: by the hot-water soak of Radix Schisandrae Bicoloris with 65 DEG C, removing peel, is ground into coarse powder after oven dry, and volatile oil is removed in distillation; Be temperature 50 C at extraction conditions in above-mentioned Fructus Schisandrae Chinensis, extract 4 times under passing into the butane of volumetric concentration 80%, it is 2 hours at every turn, merge extractive liquid, extracting solution, under 40 DEG C of conditions, leaves standstill layering after 18 hours, gets upper liquid and concentrates, the ethanol of volumetric concentration 80% is added, centrifuging and taking supernatant in concentrated solution; Adsorb supernatant by non-polar macroporous resin, with the organic solvent eluting 3 times of volumetric concentration 70%, reclaim organic solvent, cross 80 mesh sieves after vacuum drying is concentrated and namely obtain Fructus Schisandrae Chinensis extrat;
Semen Ziziphi Spinosae extract: Semen Ziziphi Spinosae is pulverized, fatty oil in squeezing Semen Ziziphi Spinosae, the Semen Ziziphi Spinosae medicinal residues squeezing fatty oil add the soak by water 3 times of 6 times amount, each 1.5 hours, merge each filtrate after filtering, filtrate added 95% ethanol after being condensed into thick paste, thick paste alcohol content is made to reach 60 ~ 80%, hold over night, concentrated after filtering, cross 80 mesh sieves after vacuum drying and namely obtain Semen Ziziphi Spinosae extract;
Fructus Crataegi extract: Fructus Crataegi is soaked 1-2h, decocts with water 3 times, decocts 2h at every turn, filters, obtains filtrate and filtering residue; By filtering residue with 85% alcohol heating reflux extract 2 times, merge extractive liquid, and above-mentioned filtrate are first extract; By first extract macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, namely mistake 80 mesh sieves obtain Fructus Crataegi extract;
Poria extract: Poria was pulverized 100 mesh sieves, the alcohol heating reflux with 85% extracts 3 times, merge extractive liquid, by macroporous resin adsorption and with 60% ethanol to low pole macroporous resin column eluting 3 times, reclaim ethanol, concentrated, cross 80 mesh sieves after vacuum drying and namely obtain Poria extract;
Radix Ginseng Rubra extract: add 8 times amount water soaking after being shredded by Radix Ginseng Rubra 2 hours, heating and refluxing extraction 2 hours, extracts 3 times, merge extractive liquid, filters, concentrated; Concentrated solution is used reverse phase silica gel column separating purification; Methanol-eluted fractions with 60% 3 times, each consumption 5L, collects eluent, concentrated, crosses 80 mesh sieves and obtain Radix Ginseng Rubra extract after vacuum drying;
Radix Astragali extract: the Radix Astragali is soaked 2h, decocts with water 2 times, decocts 2h at every turn, filters, obtains filtrate and filtering residue; By filtering residue with 85% alcohol heating reflux extract 2 times, merge extractive liquid, and above-mentioned filtrate are first extract; By first extract macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, namely mistake 80 mesh sieves obtain Radix Astragali extract;
Massa Medicata Fermentata extract: by Massa Medicata Fermentata coarse crushing, by the alcohol heating reflux lixiviate of 10 times of volumes 75%, temperature 90 DEG C, extract 2 times, time 3h, obtains crude extract; Crude extract is carried out rapid filtration under suction, crosses 80 mesh sieves after filter vacuum concentrate drying and obtain Massa Medicata Fermentata extract;
Radix Rhodiolae extract: by Radix Rhodiolae pulverizing medicinal materials, soaks 2 hours; Soaked Radix Rhodiolae is added water and uses ultrasonic assistant extraction method, extract 3 times, filter after merge extractive liquid, and obtain filtrate; By filtrate by D101 macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, mistake 80 mesh sieves obtain Radix Rhodiolae extract;
Herba Epimedii extract: pulverized by epimedium herb, the alcohol reflux with 75% 3 hours, extraction time is 3 times; Above-mentioned filtrate is merged sucking filtration, and concentrating under reduced pressure reclaims ethanol and obtains just extract, then with 95% ethanol, purified water flushing reuse; By the extraction of above-mentioned just extract, standing, sucking filtration, obtain crude extract; Above-mentioned crude extract macroporous resin column adsorbed, then use the ethanol of 50-60% to macroporous resin column eluting, eluted product reclaims eluent, and namely vacuum concentration drying rear mistake 80 mesh sieve obtains Herba Epimedii extract.
Using the extract of described crude drug proportionally fill enter capsule or directly as oral powder.
Embodiment 2
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 11 parts, Radix Clematidis extract 11 parts, Caulis Spatholobi extract 16 parts, Radix Rehmanniae Preparata extract 21 parts, Radix Angelicae Sinensis extract 11 parts, Rhizoma Polygonati extract 16 parts, Fructus Schisandrae Chinensis extrat 11 parts, Semen Ziziphi Spinosae extract 11 parts, Fructus Crataegi extract 16 parts, Poria extract 13 parts, Radix Ginseng Rubra extract 6 parts, Radix Astragali extract 26 parts, Massa Medicata Fermentata extract 13 parts, Radix Rhodiolae extract 21 parts, Herba Epimedii extract 11 parts.
Preparation method is with embodiment 1.
Embodiment 3
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 12 parts, Radix Clematidis extract 12 parts, Caulis Spatholobi extract 17 parts, Radix Rehmanniae Preparata extract 22 parts, Radix Angelicae Sinensis extract 12 parts, Rhizoma Polygonati extract 17 parts, Fructus Schisandrae Chinensis extrat 12 parts, Semen Ziziphi Spinosae extract 12 parts, Fructus Crataegi extract 17 parts, Poria extract 14 parts, Radix Ginseng Rubra extract 7 parts, Radix Astragali extract 27 parts, Massa Medicata Fermentata extract 14 parts, Radix Rhodiolae extract 22 parts, Herba Epimedii extract 13 parts.
Preparation method is with embodiment 1.
Embodiment 4
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 14 parts, Radix Clematidis extract 16 parts, Caulis Spatholobi extract 19 parts, Radix Rehmanniae Preparata extract 25 parts, Radix Angelicae Sinensis extract 14 parts, Rhizoma Polygonati extract 20 parts, Fructus Schisandrae Chinensis extrat 15 parts, Semen Ziziphi Spinosae extract 13 parts, Fructus Crataegi extract 20 parts, Poria extract 17 parts, Radix Ginseng Rubra extract 10 parts, Radix Astragali extract 29 parts, Massa Medicata Fermentata extract 15 parts, Radix Rhodiolae extract 26 parts, Herba Epimedii extract 15 parts.
Preparation method is with embodiment 1.
Embodiment 5
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 16 parts, Radix Clematidis extract 18 parts, Caulis Spatholobi extract 23 parts, Radix Rehmanniae Preparata extract 28 parts, Radix Angelicae Sinensis extract 16 parts, Rhizoma Polygonati extract 23 parts, Fructus Schisandrae Chinensis extrat 16 parts, Semen Ziziphi Spinosae extract 16 parts, Fructus Crataegi extract 23 parts, Poria extract 18 parts, Radix Ginseng Rubra extract 13 parts, Radix Astragali extract 33 parts, Massa Medicata Fermentata extract 23 parts, Radix Rhodiolae extract 28 parts, Herba Epimedii extract 17 parts.
Preparation method is with embodiment 1.
Embodiment 6
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extracts 17 parts, Radix Clematidis extracts 19 parts, Caulis Spatholobi extract 24 parts, Radix Rehmanniae Preparata extract 29 parts, Radix Angelicae Sinensis extract 17 parts, Rhizoma Polygonati extract 24 parts, Fructus Schisandrae Chinensis extrat 17 parts, Semen Ziziphi Spinosae extract 17 parts, Fructus Crataegi extract 24 parts, Poria extract 19 parts, Radix Ginseng Rubra extract 14 parts, Radix Astragali extract 34 parts, Massa Medicata Fermentata extracts 24 parts, Radix Rhodiolae extract 29 parts, Herba Epimedii extract 19 parts.
Preparation method is with embodiment 1.
Embodiment 7
The erythrocytic Chinese medicine preparation of a kind of maintenance, the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 18 parts, Radix Clematidis extract 20 parts, Caulis Spatholobi extract 25 parts, Radix Rehmanniae Preparata extract 30 parts, Radix Angelicae Sinensis extract 18 parts, Rhizoma Polygonati extract 25 parts, Fructus Schisandrae Chinensis extrat 18 parts, Semen Ziziphi Spinosae extract 18 parts, Fructus Crataegi extract 25 parts, Poria extract 20 parts, Radix Ginseng Rubra extract 15 parts, Radix Astragali extract 35 parts, Massa Medicata Fermentata extract 25 parts, Radix Rhodiolae extract 30 parts, Herba Epimedii extract 20 parts.
Preparation method is with embodiment 1.
Instructions of taking: disease initial stage: every day three times, is equivalent to two grams of crude drug weight at every turn; Disease mid-term: every day three times, be at every turn equivalent to five grams of crude drug weight; Terminal stage of a disease: every day three times, be equivalent to ten grams of crude drug weight at every turn; Disease is on the verge of the phase: every day three times, is equivalent to 20 grams of crude drug weight at every turn; Or honor doctor's advice is taken.
The curative effect of Chinese medicine preparation of the present invention is described with concrete case.
Case 1 Zhang, female, city's examination in hospital is diagnosed as early gastric caacer, takes the embodiment of the present invention 1 Chinese medicine preparation 3 months, evident in efficacy, shows erythrocyte and recover normal in erythrocyte electromicroscopic photograph.
Case 2 king so-and-so, female, it is early stage that city's examination in hospital is diagnosed as pulmonary carcinoma, takes the embodiment of the present invention 2 Chinese medicine preparation 4 months, evident in efficacy, shows erythrocyte and recover normal in erythrocyte electromicroscopic photograph.
Case 3 poplar, man, city's examination in hospital is diagnosed as leukemia, takes the embodiment of the present invention 3 Chinese medicine preparation 5 months, evident in efficacy, shows erythrocyte and recover normal in erythrocyte electromicroscopic photograph.
Case 4 Liu, female, city's examination in hospital is diagnosed as uremia, takes the embodiment of the present invention 4 Chinese medicine preparation 3 months, evident in efficacy, shows erythrocyte and recover normal in erythrocyte electromicroscopic photograph.
Case 5 Zhang, man, city's examination in hospital is diagnosed as senile dementia, takes the embodiment of the present invention 5 Chinese medicine preparation 3 months, evident in efficacy, shows erythrocyte and recover normal in erythrocyte electromicroscopic photograph.
Case 6 Zhao so-and-so, man, city's examination in hospital is diagnosed as later period of hepatocarcinoma, takes the embodiment of the present invention 6 Chinese medicine preparation 12 months, evident in efficacy, shows erythrocyte and recover normal in erythrocyte electromicroscopic photograph.
Case 7 Liu, female, city's examination in hospital is diagnosed as type ii diabetes, takes the embodiment of the present invention 7 Chinese medicine preparation 3 months, evident in efficacy, shows erythrocyte and recover normal in erythrocyte electromicroscopic photograph.
The patient that Fig. 1 to Fig. 7 shows case 1-7 takes erythrocyte photo under the Electronic Speculum before Chinese medicine preparation of the present invention, and Fig. 8 is for recovering photo under the erythrocytic Electronic Speculum of normal human after taking Chinese medicine preparation of the present invention.Find out in Fig. 1, erythrocyte fold is assembled.The erythrocyte aggregation of Fig. 2, cell wall rupture.Fig. 3 erythrocyte ringwise.Fig. 4 erythrocyte consecutive, cell wall rupture.Fig. 5 red blood cell deformation becomes similar ingot or lubricating cup state.Fig. 6 erythrocyte is broken state.Fig. 7 gauffer cell state.The normal erythrocyte of Fig. 8 is the round pie of two sides fovea centralis, and central authorities are thinner.
Below be only for explaining the detailed description of the invention that the present invention sets forth; other do not depart from the change that technical scheme of the present invention does and all fall into protection scope of the present invention on basis of the present invention; and except technology disclosed by the invention, all the other are the known prior art of those skilled in the art.

Claims (5)

1. the erythrocytic Chinese medicine preparation of maintenance, is characterized in that the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 10-18 part, Radix Clematidis extract 10-20 part, Caulis Spatholobi extract 15-25 part, Radix Rehmanniae Preparata extract 20-30 part, Radix Angelicae Sinensis extract 10-18 part, Rhizoma Polygonati extract 15-25 part, Fructus Schisandrae Chinensis extrat 10-18 part, Semen Ziziphi Spinosae extract 10-18 part, Fructus Crataegi extract 15-25 part, Poria extract 12-20 part, Radix Ginseng Rubra extract 5-15 part, Radix Astragali extract 25-35 part, Massa Medicata Fermentata extract 12-25 part, Radix Rhodiolae extract 20-30 part, Herba Epimedii extract 10-20 part;
Wherein Ramulus Cinnamomi extract: the ethanol being 95% by the weight percent concentration adding Ramulus Cinnamomi weight 15 times in Ramulus Cinnamomi carries out ultrasonic assistant extraction, Extracting temperature is 50 DEG C, and extraction time is 2 ~ 3 hours, and supersonic frequency is 30 ~ 40 KHz; Filtering and concentrating, crosses 80 mesh sieves and get final product after concentrated solution vacuum drying;
Radix Clematidis extract: clematis chinensis medicinal materials adopts the alcoholic solution heating and refluxing extraction 60min of 85% concentration of 8 times of volumes; Extracting solution is concentrated, after removing ethanol, centrifuging and taking supernatant is diluted to 0.2kg/L; Adopt n-butanol extraction; After n-butanol portion is concentrated, be separated with DA-201 type macroporous resin; Ethanol gradient elution, collects eluent, concentrating under reduced pressure; Cross 80 mesh sieves after concentrated solution vacuum drying and get final product;
Caulis Spatholobi extract: by Caulis Spatholobi pulverizing medicinal materials, adds the ethanol of 50%, reflux, extract, 3 times, each 2 hours, and extracting solution is concentrated into without alcohol taste by merge extractive liquid; Extracting solution macroporous adsorptive resins is adsorbed; First time washes with water to sugar-free reaction, and the second time ethanol elution of 30% obviously shoals to color, and the ethanol elution of third time 70% obviously shoals to color; Collect ethanol elution, reclaim ethanol, vacuum concentration drying rear mistake 80 mesh sieve obtains Caulis Spatholobi extract;
Radix Rehmanniae Preparata extract: by the coarse crushing of Radix Rehmanniae Preparata dry product, with 95% ethanol of 7 times of volumes to coarse crushing thing reflux, extract, 4 hours, then extract 2.5 hours at 95 DEG C by 6 times of water yields, filter centrifugation, with ethanol precipitate with ethanol 4 hours sucking filtration of 95% after supernatant concentration, vacuum concentration drying rear mistake 80 mesh sieve and get final product;
Radix Angelicae Sinensis extract: by Radix Angelicae Sinensis coarse crushing, adds dehydrated alcohol at extraction temperature 40-45 DEG C, extracting pressure 28-32MPa, resolves pressure 9-12 MPa, CO 2carry out extraction 8 hours under the condition of flow 10-12L/h, reclaim ethanol, vacuum concentration drying rear mistake 80 mesh sieve and get final product;
Rhizoma Polygonati extract: by Rhizoma Polygonati coarse crushing, adopts water extraction to extract, adds activated carbon decolorizing, filter to obtain extracting solution, concentrated, uses 95% alcohol settling, spends the night, and centrifugal, reclaim ethanol, namely vacuum concentration drying rear mistake 80 mesh sieve obtains Rhizoma Polygonati extract;
Fructus Schisandrae Chinensis extrat: by the hot-water soak of Radix Schisandrae Bicoloris with 65 DEG C, removing peel, is ground into coarse powder after oven dry, and volatile oil is removed in distillation; Be temperature 50 C at extraction conditions in above-mentioned Fructus Schisandrae Chinensis, extract 4 times under passing into the butane of volumetric concentration 80%, it is 2 hours at every turn, merge extractive liquid, extracting solution, under 40 DEG C of conditions, leaves standstill layering after 18 hours, gets upper liquid and concentrates, the ethanol of volumetric concentration 80% is added, centrifuging and taking supernatant in concentrated solution; Adsorb supernatant by non-polar macroporous resin, with the organic solvent eluting 3 times of volumetric concentration 70%, reclaim organic solvent, cross 80 mesh sieves after vacuum drying is concentrated and namely obtain Fructus Schisandrae Chinensis extrat;
Semen Ziziphi Spinosae extract: Semen Ziziphi Spinosae is pulverized, fatty oil in squeezing Semen Ziziphi Spinosae, the Semen Ziziphi Spinosae medicinal residues squeezing fatty oil add the soak by water 3 times of 6 times amount, each 1.5 hours, merge each filtrate after filtering, filtrate added 95% ethanol after being condensed into thick paste, thick paste alcohol content is made to reach 60 ~ 80%, hold over night, concentrated after filtering, cross 80 mesh sieves after vacuum drying and namely obtain Semen Ziziphi Spinosae extract;
Fructus Crataegi extract: Fructus Crataegi is soaked 1-2h, decocts with water 3 times, decocts 2h at every turn, filters, obtains filtrate and filtering residue; By filtering residue with 85% alcohol heating reflux extract 2 times, merge extractive liquid, and above-mentioned filtrate are first extract; By first extract macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, namely mistake 80 mesh sieves obtain Fructus Crataegi extract;
Poria extract: Poria was pulverized 100 mesh sieves, the alcohol heating reflux with 85% extracts 3 times, merge extractive liquid, by macroporous resin adsorption and with 60% ethanol to low pole macroporous resin column eluting 3 times, reclaim ethanol, concentrated, cross 80 mesh sieves after vacuum drying and namely obtain Poria extract;
Radix Ginseng Rubra extract: add 8 times amount water soaking after being shredded by Radix Ginseng Rubra 2 hours, heating and refluxing extraction 2 hours, extracts 3 times, merge extractive liquid, filters, concentrated; Concentrated solution is used reverse phase silica gel column separating purification; Methanol-eluted fractions with 60% 3 times, each consumption 5L, collects eluent, concentrated, crosses 80 mesh sieves and obtain Radix Ginseng Rubra extract after vacuum drying;
Radix Astragali extract: the Radix Astragali is soaked 2h, decocts with water 2 times, decocts 2h at every turn, filters, obtains filtrate and filtering residue; By filtering residue with 85% alcohol heating reflux extract 2 times, merge extractive liquid, and above-mentioned filtrate are first extract; By first extract macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, namely mistake 80 mesh sieves obtain Radix Astragali extract;
Massa Medicata Fermentata extract: by Massa Medicata Fermentata coarse crushing, by the alcohol heating reflux lixiviate of 10 times of volumes 75%, temperature 90 DEG C, extract 2 times, time 3h, obtains crude extract; Crude extract is carried out rapid filtration under suction, crosses 80 mesh sieves after filter vacuum concentrate drying and obtain Massa Medicata Fermentata extract;
Radix Rhodiolae extract: by Radix Rhodiolae pulverizing medicinal materials, soaks 2 hours; Soaked Radix Rhodiolae is added water and uses ultrasonic assistant extraction method, extract 3 times, filter after merge extractive liquid, and obtain filtrate; By filtrate by D101 macroporous resin adsorption and with 70% ethanol to macroporous resin column eluting 3 times, reclaim ethanol, concentrated, after vacuum drying, mistake 80 mesh sieves obtain Radix Rhodiolae extract;
Herba Epimedii extract: pulverized by epimedium herb, the alcohol reflux with 75% 3 hours, extraction time is 3 times; Above-mentioned filtrate is merged sucking filtration, and concentrating under reduced pressure reclaims ethanol and obtains just extract, then with 95% ethanol, purified water flushing reuse; By the extraction of above-mentioned just extract, standing, sucking filtration, obtain crude extract; Above-mentioned crude extract macroporous resin column adsorbed, then use the ethanol of 50-60% to macroporous resin column eluting, eluted product reclaims eluent, and namely vacuum concentration drying rear mistake 80 mesh sieve obtains Herba Epimedii extract.
2. the erythrocytic Chinese medicine preparation of a kind of maintenance according to claim 1, is characterized in that the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 11-17 part, Radix Clematidis extract 11-19 part, Caulis Spatholobi extract 16-24 part, Radix Rehmanniae Preparata extract 21-29 part, Radix Angelicae Sinensis extract 11-17 part, Rhizoma Polygonati extract 16-24 part, Fructus Schisandrae Chinensis extrat 11-17 part, Semen Ziziphi Spinosae extract 11-17 part, Fructus Crataegi extract 16-24 part, Poria extract 13-19 part, Radix Ginseng Rubra extract 6-14 part, Radix Astragali extract 26-34 part, Massa Medicata Fermentata extract 13-24 part, Radix Rhodiolae extract 21-29 part, Herba Epimedii extract 11-19 part.
3. the erythrocytic Chinese medicine preparation of a kind of maintenance according to claim 1, is characterized in that the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 12-16 part, Radix Clematidis extract 12-18 part, Caulis Spatholobi extract 17-23 part, Radix Rehmanniae Preparata extract 22-28 part, Radix Angelicae Sinensis extract 12-16 part, Rhizoma Polygonati extract 17-23 part, Fructus Schisandrae Chinensis extrat 12-16 part, Semen Ziziphi Spinosae extract 12-16 part, Fructus Crataegi extract 17-23 part, Poria extract 14-18 part, Radix Ginseng Rubra extract 7-13 part, Radix Astragali extract 27-33 part, Massa Medicata Fermentata extract 14-23 part, Radix Rhodiolae extract 22-28 part, Herba Epimedii extract 13-17 part.
4. the erythrocytic Chinese medicine preparation of a kind of maintenance according to claim 1, is characterized in that the crude drug comprising following weight proportion is made:
Ramulus Cinnamomi extract 14 parts, Radix Clematidis extract 16 parts, Caulis Spatholobi extract 19 parts, Radix Rehmanniae Preparata extract 25 parts, Radix Angelicae Sinensis extract 14 parts, Rhizoma Polygonati extract 20 parts, Fructus Schisandrae Chinensis extrat 15 parts, Semen Ziziphi Spinosae extract 13 parts, Fructus Crataegi extract 20 parts, Poria extract 17 parts, Radix Ginseng Rubra extract 10 parts, Radix Astragali extract 29 parts, Massa Medicata Fermentata extract 15 parts, Radix Rhodiolae extract 26 parts, Herba Epimedii extract 15 parts.
5. the erythrocytic Chinese medicine preparation of a kind of maintenance according to any one of claim 1-4, it is characterized in that described Chinese medicine preparation be using the extract of described crude drug proportionally fill enter capsule or directly as oral powder.
CN201410595282.4A 2014-10-30 2014-10-30 Chinese herbal preparation for maintaining red blood cells Pending CN104398794A (en)

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