CN104398522A

CN104398522A - Medicine for treating fungal dermatoses and eczema infection and preparation method thereof

Info

Publication number: CN104398522A
Application number: CN201410782336.8A
Authority: CN
Inventors: 吴书清
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-16
Filing date: 2014-12-16
Publication date: 2015-03-11

Abstract

The invention discloses medicine for treating fungal dermatoses and eczema infection and a preparation method thereof. Each 10 g of the medicine contains 200-300 mg of metronidazole, 100-110 mg of ketoconazole, 10-50 mg of borneol and 5-6 mg of clobetasol propionate. The externally applied agent of the medicine integrates the advantages and supplements the disadvantages of the components, contains metronidazole capable of broad-spectrum antibacterial and anti-parasitic, ketoconazole capable of highly antifungal, as well as glucocorticoid and borneol, is powerful in anti-inflammatory and antiallergic efficacies, has excellent effect on dermatoses including fungal infection, eczema infection, acne, acne rosacea, skin itch and the like, becomes effective as soon as being applied, rapidly relieves itching and is durable in curative effect.

Description

A kind ofly treat medicine of dermatomycosis and eczema infection and preparation method thereof

Technical field

The invention belongs to the technical field of dermatosis medication, be specifically related to a kind ofly treat medicine of dermatomycosis and eczema infection and preparation method thereof.

Background technology

Dermatomycosis refers to a large class infectious disease of human skin caused by pathogenic fungi and mucosa, hair and first-class skin appendages.

Eczema is a kind of common anaphylaxis dermatosis.The erythra of a series of lasting and supervention made a general reference usually in eczema one word, as rubescent, edema, pruritus and dry be sign, can with forming a scab, peel off, bubble, ftracture, hemorrhage or oozing of blood etc.It is clinical common a kind of dermatosis.

Said two devices a common patient fall ill simultaneously, and delay is difficult, recurrent exerbation.In current city, medicine for external use is numerous, as miconazole cream, the medicine for external use such as PIKANGWANG, the dermatosis effect caused fungal infection is fine, but to eczema and other skin infection effects bad, even invalid.Though and for example fluocinolone acetonide ointment, dermatitis equality medicine are to eczema effectively, invalid to fungal infection.The medicine for external use of the present invention's preparation, get each strength, mend its deficiency, existing broad-spectrum antiseptic, antiparasitic metronidazole, have again the ketoconazole of powerful antifungal, join glucocorticoid and Borneolum Syntheticum again, antiinflammatory, antiallergic effect are powerful, fine to dermatosis effects such as cutaneous fungal infection, eczema infection, acne, acne rosacea, skin pruritus, can a wiping take effect, Quick itch stopping, persistent.

Summary of the invention

The object of this invention is to provide a kind of can simultaneously medicine of effectively treating dermatomycosis and eczema infection and preparation method thereof.

Treat a medicine for dermatomycosis and eczema infection, every 10 grams include: metronidazole 200-300mg, ketoconazole 100-110mg, Borneolum Syntheticum 10-50mg, clobetasol propionate 5-6mg, and adjuvant is medicinal cream substrate.

The preparation method of described treatment dermatomycosis and the medicine of eczema infection, is deployed into emulsifiable paste shape by each component mixing.Novel medicinal emulsifiable paste matrix, advantage: mastic is pure white, glossy, fine and smooth, moisture retention is strong, oily but not greasy.The permeability of medicine can be strengthened, curative effect of medication is improved greatly.High temperature resistant, anti-low temperature, not breakdown of emulsion, the preparation of any material medicine can be held, be specially adapted to small-middle hospital dermatological preparations and dermatosis clinic, do not need any equipment, be adjustable various external breast (soft) cream at normal temperatures, dermatosis pharmaceutical raw material marketing center is on sale.

Be suitable for disease: be used for the treatment of the fungal infection such as various tinea corporis, tinea cruris, tinea versicolor, the tinea manuum, tinea pedis, eczema infection, neurodermatitis, folliculitis, papular urticaria, mosquito bite, skin pruritus, impetigo, acne, miliaria, scabies, acne rosacea etc.

Usage: be applied to affected part outward, 2 times on the one.

Untoward reaction:

1, accidental anaphylaxis is as erythra, pruritus or skin irritation burn feeling.

2, visible dermis atrophy during prolonged application, blood capillary anti-tensile, pigmentation and secondary infection.

Taboo:

1, to any composition allergy sufferers forbidding of this product.

2, the viral infection person such as born of the same parents' rash, chickenpox forbidding.

Points for attention:

1, anemia of pregnant woman and age of sucking patient forbidding.

2, contact eyes and mucosa (as mouth, nose etc.) is avoided.

3, agents area occurs that the situation such as burn feeling and redness should be stopped using, and topical remedy is cleaned, and inquires doctor if desired.

4, use is no more than 4 weeks continuously, and the thin thin places of skin such as face, oxter, groin, pudendum use continuously and are no more than 2 weeks, and symptom not alleviation person should inquire doctor.

5, need not wrap up after this product coating.

6, skin stain tear must not be used for.

7, infant and child are cautious use of.

8, child must use under adult's monitoring.

9, prohibit the use when this product character changes.

10, as used other medicines, Ref Dr or pharmacist before application this product.

Drug interaction: as used drug interaction may occur with other drug simultaneously, detailed Ref Dr or pharmacist.

Pharmacological action: metronidazole tool wide spectrum anaerobe resistant and protozoacide effect, external has effects such as well treating scabies, tinea pedis, papular urticaria, psoriasis to have great mass of data to report, ketoconazole belongs to imidazoles antifungal agent, bacteriostasis and sterilization effect is had to dermophyte, yeast, dimorphic fungus and Mycophytes, the activity of cytochrome of selectivity interference fungus can be improved, thus the biosynthesis of ergosterol on Antifungi cell membrane; Clobetasol propionate is glucocorticoid, and to chronic eczema, neurodermatitis etc. have powerful antiinflammatory, anti-allergic effects, Borneolum Syntheticum sterilization, antiinflammatory, refrigerant antipruritic.

Various medicine is combined, and both has good curative effect to the dermatosis of fungal infection, has specially good effect again to dermatosiss such as eczema, skin allergy, protozoan infection and bacteriological infection.

By the clinical verification of nearly 30 years, this medicine was efficient, safety, and side effect is few, a kind of external specific drug really.

Detailed description of the invention

Be intended to further illustrate the present invention below in conjunction with embodiment, and unrestricted the present invention.

Embodiment 1

Every 10 grams include: metronidazole 220mg, ketoconazole 110mg, Borneolum Syntheticum 40mg, clobetasol propionate 5mg.Adjuvant is novel medicinal emulsifiable paste matrix.

Embodiment 2

Every 10 grams include: metronidazole 260mg, ketoconazole 100mg, Borneolum Syntheticum 20mg, clobetasol propionate 5mg.Adjuvant is novel medicinal emulsifiable paste matrix.

Embodiment 3

Every 10 grams include: metronidazole 280mg, ketoconazole 100mg, Borneolum Syntheticum 10mg, clobetasol propionate 6mg.Adjuvant is novel medicinal emulsifiable paste matrix.

The therapeutic effect of medicine of the present invention:

One, skin allergy

Timing statistics: on January 1 ,-2014 years on the 1st January in 2013

Clinical data: skin allergy patient 695 example, wherein male 351 example, age 3-75 year, women 344 example, age 3-79 year.

Therapeutic Method: first by affected part wash clean, then be applied to affected part by outside plaster of the present invention, every day 2 times.

Therapeutic outcome: cure 611 examples, treat recovery from illness in 3-5 days.

Effective 79 examples, treat and are almost recovered after 3-5 days, but recur once in a while after drug withdrawal, need continue medication.

Invalid 5 examples.

Effective percentage reaches 99.28%.

Typical case:

Liu so-and-so, man, 50 years old

Main suit: scalp itch plays goose pimples flowing water, very itches 3 days.

History of present illness: patient occurs scalp itch after having hair dyed before 3 days, scratches scalp stream and sticks water, incrustation, time light time heavy, recurrent exerbation, takes antiallergic agent invalid (medicine is not quite clear) certainly.

Check: scalp portion large stretch of erythema, blister, scratch the visible spilling water in place, erosion and blood crusts, yellow crusts, clear along the visible boundary of forehead, slightly infiltration, flushing, spilling water and skin lesion.

Diagnosis: skin allergy.

Treatment: with 0.5% potassium permanganate cleaning head, then use medicine affected part of exterior coating of the present invention, every day 2 times.

Antipruritic after treating 1 time, not flowing water after 2 days, recovery from illness in 3 days.

Two, eczema

Timing statistics: on January 1 ,-2014 years on the 1st January in 2013

Clinical data: eczema patients 329 example, wherein male 155 example, age 2-79 year, women 174 example, age 2-82 year.Therapeutic Method: first by affected part wash clean, then be applied to affected part by outside plaster of the present invention, every day 2 times.

Therapeutic outcome: cure 105 examples, treat each transference cure after 3-7 days, follow up a case by regular visits to half a year and do not send out.

Effective 175 examples, treat symptom after 3-7 days and substantially disappear, but recur once in a while after drug withdrawal, need continue treatment.

Invalid 49 examples.

Effective percentage 85.1%.

Typical case:

Lee, man, 20 years old

Before patient April, mouth and nose surrounding, external auditory meatus, near the eyes, umbilicus week begins to feel pruritus in the place of grade, and broken skin is oozed out then, and sufferings unbearably.Check: near the eyes, external auditory meatus, nostril, umbilicus week and the visible inflammatory maculopapule in external genitalia and anus place, slightly ooze out, rotten to the corn, and part has crocus crust, and sufferings are held concurrently mutually.

Diagnosis: eczema.

Treatment: be applied to affected part with medicine for external use of the present invention, every day 2 times, recovery from illness in a week, does not send out so far.

Three, tinea cruris

Timing statistics: on January 1 ,-2014 years on the 1st January in 2013

Yesterday bed data: tinea cruris patient 11 example, wherein male 9 example, age 14-39 year, women 2 example, age 20-35 year.

Therapeutic Method: affected part is cleaned, then use medicine affected part of exterior coating of the present invention, every day 2 times.

Therapeutic effect: cure 7 examples, medication 7 days healing person 5 examples, 14 days healing person 2 examples, follow up a case by regular visits to half a year and do not send out.

Effective 3 example, medication after 14 days symptom be clearly better, recur once in a while after drug withdrawal.

Invalid 1 example.

Total effective rate 90.9%.

Typical case:

Zhang, man, 19 years old

Main suit: groin, erythema in haunch companion pruritus 3 years, increases the weight of January.

History of present illness: patient saw before 3 years that inside groin, several Semen phaseoli radiati Taegu is examined, and then have vesicle, outwards develop from center, center has spontaneous recovery to be inclined to, pruritus, personal PIYANPING is coated with outward, and effect was fine at that time, but aggravate on the contrary after drug withdrawal, and constantly outwards expansion, delay is so far.

Check: groin inner annular damages, and there is vesicle at edge, the narrow protuberance that pimple is formed, buttocks is shown in small pieces erythema.

Diagnosis: tinea cruris.

Treatment: adopt medicine for external use of the present invention to be applied to affected part, every day 2 times, after 1 week, all diseases disappear, and for consolidate curative effect uses one week again, do not recur so far.

Four, vitamin B1 deficiency

Timing statistics: on January 1 ,-2014 years on the 1st January in 2013

Clinical data: beriberi patient 255 example, wherein male 134 example, age 3-55 year, women 121 example, age 3-49 year.Therapeutic Method: first by affected part wash clean, then be applied to affected part by outside plaster of the present invention, every day 2 times.

Therapeutic outcome: cure 193 examples, cures, follows up a case by regular visits to half a year and do not send out for average 3-7 days.

Effective 41 examples, medication is cured for 7 days afterwards substantially, but recurs once in a while after drug withdrawal.

Invalid 21 examples.

Total effective rate 91.76%.

Typical case:

Zhang, female, 30 years old

Patient's biped general vitamin B1 deficiency is more than 1 year, and at the bottom of biped and each toe seam place pachylosis is dry and cracked, and instep and both sides show dry and cracked desquamation and very itch, and have vesicle, and once use daktarin, econazole, PIYANNING DING class all invalid, symptom as before, do not feel any better by the state of an illness.Advise its his medicine of stopping using, be applied to affected part, every day 2 times with medicine for external use of the present invention, medication one day is antipruritic, and after one week, healing, for consolidate curative effect uses one week again, does not send out so far.

Claims

1. treat a medicine for dermatomycosis and eczema infection, it is characterized in that, every 10 grams include: metronidazole 200-300mg, ketoconazole 100-110mg, Borneolum Syntheticum 10-50mg, clobetasol propionate 5-6mg, and adjuvant is medicinal cream substrate.

2. the preparation method of the medicine for the treatment of dermatomycosis according to claim 1 and eczema infection, is characterized in that, each component mixing is deployed into emulsifiable paste shape.