CN104374929B - Many dynamic exposure units of concentration animal mouth and nose suction - Google Patents
Many dynamic exposure units of concentration animal mouth and nose suction Download PDFInfo
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- CN104374929B CN104374929B CN201310351071.1A CN201310351071A CN104374929B CN 104374929 B CN104374929 B CN 104374929B CN 201310351071 A CN201310351071 A CN 201310351071A CN 104374929 B CN104374929 B CN 104374929B
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- 241001465754 Metazoa Species 0.000 title claims abstract description 43
- 239000000443 aerosol Substances 0.000 claims abstract description 56
- 238000001856 aerosol method Methods 0.000 claims abstract description 15
- 238000010790 dilution Methods 0.000 claims description 45
- 239000012895 dilution Substances 0.000 claims description 45
- 230000006698 induction Effects 0.000 claims description 29
- 230000003068 static effect Effects 0.000 claims description 25
- 238000010171 animal model Methods 0.000 claims description 14
- 230000008676 import Effects 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 239000007789 gas Substances 0.000 description 49
- 238000002474 experimental method Methods 0.000 description 16
- 239000000463 material Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 9
- 239000002904 solvent Substances 0.000 description 6
- 238000011160 research Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000002110 toxicologic effect Effects 0.000 description 4
- 231100000027 toxicology Toxicity 0.000 description 4
- 239000002912 waste gas Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 231100000727 exposure assessment Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
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- 238000004088 simulation Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
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Abstract
The invention discloses a kind of many dynamic exposure units of concentration animal mouth and nose suction, including experimental group exposure chamber (1), wherein, the experimental group exposure chamber (1) includes first segment exposure chamber (11) and second section exposure chamber (12)；The aerosol processing unit being diluted to the aerosol entered by the first segment exposure chamber (11) in the second section exposure chamber (12) is additionally provided between the first segment exposure chamber (11) and the second section exposure chamber (12)；The aerosol processing unit is additionally operable to make to enter uniform concentration distribution of the aerosol in the second section exposure chamber (12) in the second section exposure chamber (12).The aerosol for entering second section exposure chamber by first segment exposure chamber is diluted by aerosol processing unit, makes the aerosol concentration in first segment exposure chamber different with aerosol concentration in second section exposure chamber.
Description
Technical field
The present invention relates to animal suction toxicological experiment field, more particularly to a kind of many concentration animal mouth and nose suction dynamics are sudden and violent
Reveal unit.It is various available for suction toxicity Drug safety assessment, agricultural chemicals acute toxicity suction experimental study, structure animal COPD
Disease model and its curative effect of medication experimental study, atmosphere pollution are to research of animal breath systematic influence etc..
Background technology
At present, it is to suck in the related various scientific researches of toxicity, particularly some are to human health harmful substance
Research, such as PM2.5, due to that can not can not test directly or to the mankind first, so often to use experimental animal to enter
Row suction Exposure Assessment.Therefore, animal exposing device has in industry, agricultural, medical science, environmental pollution and military science research
It is widely applied.EXPERIMENT STUDY ON SUBCHRONIC or the evaluation of a kind of material are completed, the animal exposure for carrying out multiple dosage is generally required
Experiment.Animal exposing device of the prior art is all single concentration, i.e., once experiment can only carry out the animal of a dosage group
Exposure, will carry out the animal exposure test of multiple dosage groups, it is necessary to utilize many set animal exposing devices or passed through with set of device
Many experiments could be completed, it is impossible to realized and carried out many concentration zooperies simultaneously in same set of suction exposing device and compare
Analysis.
Therefore exist following not enough：It can not enter simultaneously in same experimental facilities and at various concentrations in the prior art
Thing of taking action sucks toxicological experiment.
The content of the invention
The purpose of the embodiment of the present invention is to provide a kind of many dynamic exposure units of concentration animal mouth and nose suction, solves existing
The problem of animal suction toxicological experiment can not being carried out in same experimental facilities and at various concentrations simultaneously in technology.
To achieve these goals, the invention provides a kind of many dynamic exposure units of concentration animal mouth and nose suction, including
Experimental group exposure chamber, wherein, the experimental group exposure chamber includes first segment exposure chamber and second section exposure chamber；In the first segment
It is additionally provided with and is exposed to entering the second section by the first segment exposure chamber between exposure chamber and the second section exposure chamber
The aerosol processing unit that indoor aerosol is diluted；The aerosol processing unit is additionally operable to make to enter described second
Save uniform concentration distribution of the aerosol in exposure chamber in the second section exposure chamber.
Preferably, the aerosol processing unit is concentration dilution device, and the concentration dilution device is arranged on the first segment
Between exposure chamber and the second section exposure chamber, the first segment exposure chamber and the second section exposure chamber are dilute by the concentration
Device is released to be connected.
Preferably, the experimental group exposure chamber also includes Section of three exposure chamber, the second section exposure chamber and the described 3rd
The concentration dilution device is provided between section exposure chamber.
Preferably, in addition to exposure unit base, fixing device for experimental animal and control group exposure chamber；The control group exposure
Room is arranged on the top of the experimental group exposure chamber；The fixing device for experimental animal is arranged on the experimental group exposure chamber and control
The periphery of group exposure chamber.
Preferably, the experimental group exposure chamber includes inner cylinder and outer barrel；
The concentration dilution device is arranged in the inner cylinder；
The first end of the inner cylinder is provided with the first aerosol import, in use, the second end seal of the inner cylinder is closed；
The first end closing of the outer barrel, the second end of the outer barrel is provided with passage；
The connecting tube with the intracavity inter-connection of the fixing device for experimental animal, the outer barrel and institute are provided with the inner cylinder
State the intracavity inter-connection of fixing device for experimental animal.
Preferably, the experimental group exposure chamber can rotate relative to the exposure unit base.
Preferably, it is additionally provided with gas inlet pipe on the inner cylinder.
Preferably, the concentration dilution device includes front piece, middle member and back member；
The air inlet of gas first is provided with the front piece, is connected with the gas inlet pipe；
Cylindricality cavity is offered in the rear end of the middle member, the back member includes being used to cover recessed in the cylindricality
Cover plate at the opening of chamber；Cavity formation first gas static pressure chamber between the cover plate and the cylindricality cavity, the cover plate
With the cylindricality cavity opening place plane between have gap, the gap be static pressure chamber outlet；
The back member also includes the gas inlet pipe being vertically set on the surface of the cover plate, the gas inlet
External screw thread is provided with the outer surface of pipe, is provided between the air inlet of gas first and the cylindricality cavity and the outer spiral shell
The internal thread through hole that line is engaged；The end of the gas inlet pipe is evenly arranged with multiple ventholes.
Preferably, there is space between the inwall of the concentration dilution device and the inner cylinder.
Preferably, the concentration dilution device includes second gas static pressure chamber, mixing induction tunnel and hybrid chamber and the second thing
Matter import, the first end of the mixing induction tunnel is the first matter inlet, and the second end of the mixing induction tunnel is mixed with described
Chamber is connected；Second matter inlet is the gap being arranged on the tube wall of the mixing induction tunnel, and the gap is by mutual
Parallel the first face and the second face is formed；The second gas static pressure chamber is annular housing, is arranged on the mixing induction tunnel
Periphery, the second gas static pressure chamber is connected by second matter inlet with the mixing induction tunnel, second gas
Gas feed is provided with body static pressure chamber.
Preferably, first face is circular conical surface, the circular conical surface with described to mix induction tunnel coaxial.
The embodiment of the present invention is molten to the gas for entering second section exposure chamber by first segment exposure chamber by aerosol processing unit
Glue is diluted, and makes the aerosol concentration in first segment exposure chamber different with aerosol concentration in second section exposure chamber.The gas is molten
Glue processing unit makes the aerosol extinction entered in each section exposure chamber evenly, the suction point position in approximately the same plane
Concentration is consistent.
According to the accompanying drawings to the detailed description of the specific embodiment of the invention, those skilled in the art will be brighter
Above-mentioned and other purposes, the advantages and features of the present invention.
Brief description of the drawings
Some specific embodiments of the present invention are described in detail by way of example, and not by way of limitation with reference to the accompanying drawings hereinafter.
Identical reference denotes same or similar part or part in accompanying drawing.It should be appreciated by those skilled in the art that these
What accompanying drawing was not necessarily drawn to scale.In accompanying drawing：
Fig. 1 cuts open for the front of many dynamic exposure unit embodiments one of concentration animal mouth and nose suction provided in an embodiment of the present invention
View；
The structural representation of the concentration dilution device for the embodiment one that Fig. 2 provides for the present invention；
Fig. 3 cuts open for the front of many dynamic exposure unit embodiments two of concentration animal mouth and nose suction provided in an embodiment of the present invention
View；
The structural representation of the concentration dilution device for the embodiment two that Fig. 4 provides for the present invention；
The elevational cross-sectional view of the first segment exposure chamber for the experimental group exposure chamber that Fig. 5 provides for the present invention；
The vertical view cutaway drawing of the first segment exposure chamber for the experimental group exposure chamber that Fig. 6 provides for the present invention.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with accompanying drawing to specific real
Example is applied to be described in detail.
The embodiment of the present invention one provides a kind of many dynamic exposure units of concentration animal mouth and nose suction, such as Fig. 1 and Fig. 2 institutes
Show, many dynamic exposure units of concentration animal mouth and nose suction include experimental group exposure chamber 1, wherein, experimental group exposure chamber 1 includes first
Save exposure chamber 11 and second section exposure chamber 12；It is additionally provided between first segment exposure chamber 11 and second section exposure chamber 12 to by
The aerosol processing unit that the aerosol that one section exposure chamber 11 is entered in second section exposure chamber 12 is diluted；Aerosol processing
Device is additionally operable to make to enter uniform concentration distribution of the aerosol in second section exposure chamber 12 in second section exposure chamber 12.This
Inventive embodiments are diluted by aerosol processing unit to the aerosol for entering second section exposure chamber by first segment exposure chamber,
Make the aerosol concentration in first segment exposure chamber different with aerosol concentration in second section exposure chamber.The aerosol processing unit makes
The aerosol extinction entered in each section exposure chamber is evenly.The gas in each section exposure chamber can be included herein by being uniformly distributed
Collosol concentration is consistent；Also distribution of the concentration including aerosol in the section exposure chamber changes in rule, in the section
The concentration of each layer of same circumferential location in exposure chamber is consistent.
Aerosol processing unit is concentration dilution device 4, and it is sudden and violent with second section that concentration dilution device 4 is arranged on first segment exposure chamber 11
Reveal between room 12, first segment exposure chamber 11 is connected with second section exposure chamber 12 by concentration dilution device 4.In first segment exposure chamber
11 porch can also set concentration dilution device 4.Experimental group exposure chamber 1 also includes Section of three exposure chamber 13, second section exposure
Concentration dilution device 4 is provided between room 12 and Section of three exposure chamber 13.Many dynamic exposure units of concentration animal mouth and nose suction are also wrapped
Include exposure unit base 3, fixing device for experimental animal 6 and control group exposure chamber 5；Control group exposure chamber 5 is arranged on experimental group exposure
The top of room 1；Fixing device for experimental animal 6 is arranged on the periphery of exposure chamber 1.
According to embodiments of the present invention, it is seen then that the aerosol in first segment exposure chamber 11 enters by concentration dilution device 4
Two section exposure chambers 12, are carried out by 4 pairs of aerosols for entering second section exposure chamber 12 by first segment exposure chamber 11 of concentration dilution device
Dilution, makes the aerosol concentration in first segment exposure chamber 11 different with aerosol concentration in second section exposure chamber 12.Pass through concentration
4 pairs of aerosols for entering Section of three exposure chamber 13 by second section exposure chamber 12 of diluter are diluted, and make second section exposure chamber 12
13 aerosol concentrations are different in interior aerosol concentration and Section of three exposure chamber.And then realize in same experimental facilities and many
Plant and animal suction toxicological experiment is carried out under concentration, be easy to the control for the control and experiment tested under various concentrations.
Experimental group exposure chamber 1 includes inner cylinder 101 and outer barrel 102；Concentration dilution device 4 is arranged in inner cylinder 101；Inner cylinder 101
First end be provided with the first aerosol import 111, concentration dilution device 4 can also be set at the first aerosol import 111.With
Aerosol generator connection in experimental facilities, the second end seal of inner cylinder 101 is closed, in order to be easy to cleaning after testing, in inner cylinder
101 the second end bottom is provided with aperture, is blocked during experiment with plug, closes the second end seal of inner cylinder 101；The of outer barrel 102
One end is closed, and the second end of outer barrel 102 is provided with passage, is connected with the aspirating hole in experimental facilities, i.e., with being arranged on cruelly
Stomata 31 is connected in dew unit base 3；The connecting tube 15 being connected with fixing device for experimental animal 6 is provided with inner cylinder 101；Outside
Cylinder 102 is connected with fixing device for experimental animal 6, can by animal mouth and nose setting respiratory siphon be connected, or in connecting tube
15 set gap to be connected with the mouth wall of fixator connector.In experiment, the first aerosol is passed through by aerosol generator
Import 111 inputs aerosol into inner cylinder 101, is absorbed by connecting tube 15 by animal, the waste gas and unnecessary gas of animal exhalation
Colloidal sol is evacuated pumping by passage and stomata 31 and walked, and prevents the exhaust emission aerosol of exhalation.
Gas inlet pipe 2 is additionally provided with inner cylinder 101, gas inlet pipe 2 is used to be passed through air into concentration dilution device 4, to gas
Colloidal sol is diluted.Sampling pipe 7 is additionally provided with inner cylinder 101, sampling pipe 7 is used to gather the dense of the aerosol in each section exposure chamber
Degree.
12 fixing device for experimental animal being disposed on the same plane are provided with above the outer barrel of second section exposure chamber 12
6, it is connected by connecting tube 15 with the inner cylinder of second section exposure chamber 12, at the connecting tube by the inner cylinder of first segment exposure chamber 11
And the concentration dilution device 4 set between the connecting tube of the inner cylinder of second section exposure chamber 12, make to enter second section exposure chamber 12
The concentration even circumferential distribution of aerosol at the connecting tube 15 of inner cylinder, the concentration of aerosol is consistent at the mouth of connecting tube 15,
The concentration of each layer of the same circumferential location i.e. in the section exposure chamber is consistent, it is ensured that each animal is drawn into
Concentration in mouth and nose is consistent；The concentration of aerosol in each section exposure chamber be it is the same, it is only dense before and after concentration dilution device
Degree is different, i.e., the concentration of the aerosol in each section exposure chamber is inconsistent, one in aerosol in such as first segment exposure chamber
Divide aerosol to be absorbed by animal, remaining aerosol continues to flow downward, second section exposure is entered after concentration dilution device
It is indoor.By changing the ratio of aerosol and diluent gas, different diluted concentrations can be obtained.Following table show many concentration
It is dense in every section exposure chamber that the dynamic exposure unit of the animal mouth and nose suction diluting gas flow certain by adjusting is obtained
Degree distribution (unit：Every cubic metre of milligram)：
| Interface | 1 | 2 | 3 | 4 | 5 | 6 |
| First segment | 4950 | 4930 | 4870 | 4860 | 5100 | 5090 |
| Second section | 985 | 993 | 971 | 985 | 1021 | 1012 |
| Section three, | 197 | 201 | 197 | 195 | 196 | 187 |
| Interface | 7 | 8 | 9 | 10 | 11 | 12 |
| First segment | 5060 | 4930 | 4970 | 4780 | 4860 | 4920 |
| Second section | 987 | 1020 | 978 | 975 | 983 | 987 |
| Section three, | 193 | 189 | 205 | 196 | 203 | 207 |
As seen from the above table, the dilution effect of many dynamic exposure units of concentration animal mouth and nose suction is relatively good, after dilution
Often the aerosol concentration in section exposure chamber is convenient for contrast experiment than more uniform.
Concentration dilution device 4 is may also set up at the first aerosol import 111, the gas for diluting aerosol generator generation
The concentration of colloidal sol, to meet the requirement of experiment.
As shown in figure 1, many dynamic exposure units of concentration animal mouth and nose suction also include control group exposure chamber 5, reality is arranged on
Test the top of group exposure chamber 1.Experimental group exposure chamber 1 can rotate relative to exposure unit base 3 and/or control group exposure chamber 5.
Air intlet 51 is provided with control inner cylinder in control group exposure chamber 5, and the waste gas of the waste gas for pumping animal exhalation goes out
Mouth 52.
As shown in Fig. 2 a kind of concentration dilution device 4 includes mixing induction tunnel 406 and hybrid chamber 407, mixing induction tunnel 406
First end is the first matter inlet 401, and the second end of mixing induction tunnel 406 is connected with hybrid chamber 407；Wherein, in addition to
Two matter inlets 403, the second matter inlet 403 is the gap being arranged on the tube wall of mixing induction tunnel 406, and gap is by mutually putting down
Capable the first face and the second face is formed.First face is circular conical surface, and circular conical surface is coaxial with mixing induction tunnel 406.Gap is in the second thing
Tilted on the flow direction of matter towards the direction of hybrid chamber 407.Hybrid chamber 407 includes the be connected with mixing induction tunnel 406
One end cone-shaped cavity, the cylindrical chamber of interlude and the second end toper cavity, the end of the second end toper cavity offers mixing
Matter discharge port 408.First material is aerosol, and the second material is air.The gas-solvent import slot-shaped by setting, makes
Air inlet is evenly, more stable, and dilution effect is more preferable.By setting the direction of the second matter inlet, make the pressure difference at gap two ends
With making gas-solvent enter in hybrid chamber, such a setting can prevent the first material or the second material from flowing backwards, influence dilution efficiency.
The thin hybrid chamber in thick two, forms vortex in hybrid chamber, further makes mixing evenly in the middle of by setting.
The width in gap is adjustable, and the width adjusting scope in gap is 0-6mm.Specifically, mixing induction tunnel 406 is by gap point
Part I and Part II are cut into, is connected through a screw thread between Part I and Part II.By setting gap width
It is adjustable, to adjust the second material inlet, it is easy to be applied to a variety of occasions, a variety of diluted concentrations.Can also be by controlling air
Diluted concentration required for input quantity or the regulation of aerosol input quantity.By substantial amounts of experimental verification and digital simulation point
Analysis, the effect of the width in gap between 0-6mm preferably, if more than 6mm, effect is poor.
Also include being provided with gas feed 402, second gas on second gas static pressure chamber 405, second gas static pressure chamber 405
Static pressure chamber 405 is connected by the second matter inlet 403 with mixing induction tunnel 406.Second gas static pressure chamber 405 is annular chamber
Body, is arranged on the periphery of mixing induction tunnel 406；First matter inlet 401 is tapered opening, and tapered opening is entered towards the first material
Mouth side.By setting second gas static pressure chamber 405, the second material is set to be introduced into second gas static pressure chamber 405, after being uniformly distributed,
The second matter inlet 403 is entered back into, makes the gas-solvent of entrance evenly, then mixed effect is more preferable.Mixing induction tunnel 406 includes
The first paragraph induction tunnel and second segment induction tunnel set gradually along the flow direction of the first material, the section of first paragraph induction tunnel
Product is less than the sectional area of second segment induction tunnel, and gap is arranged on the tube wall of second segment induction tunnel.It can be prevented by such a setting,
When first material flows from the top down, there are some liquid or suspended particulate blocks gap, that is, block the second matter inlet, make
Forming apparatus can not normally be run.
Gas-solvent import is used as in the unremitting gap coniform by setting, and makes air inlet evenly, more stable, dilution
The concentration of effect more preferably, after mixing or dilution is stable, is evenly distributed.By setting the direction of the second matter inlet, make gap two
The differential pressure action at end, makes gas-solvent enter in hybrid chamber, and such a setting can prevent the first material or the second material from flowing backwards, influence
Dilution efficiency.By setting the adjustable of gap width, to adjust the second material inlet, it is easy to be applied to a variety of occasions, it is a variety of
Diluted concentration.The thin hybrid chamber in thick two, forms vortex in hybrid chamber, further makes mixing evenly in the middle of by setting.
By setting gas-static chamber, the second material is set to be introduced into gas-static chamber, gap can make gas produce hydrostatic pressure, so that
After being distributed with even circumferential, the second matter inlet is entered back into, the gas-solvent circle distribution for making entrance evenly, then mixes effect
Fruit is more preferably.
As shown in figure 3, the embodiment of the present invention two provides another many dynamic exposure units of concentration animal mouth and nose suction, such as
Shown in Fig. 4, the concentration dilution device 4 in embodiment two includes front piece 46, middle member 47 and the back member of bullet shape
48；The first air inlet of gas 41 is provided with front piece 46, is connected with gas inlet pipe 2；Concentration dilution device 4 is entered by gas
Pipe 2 is fixed in inner cylinder 101.Cylindricality cavity is offered in the rear end of middle member 47, back member 48 includes being used to cover
Cover plate at the opening of cylindricality cavity；Cavity formation first gas static pressure chamber 44 between cover plate and cylindricality cavity, cover plate with
Cylindricality cavity opening place plane between have gap, gap be static pressure chamber outlet 45；Back member 48 also includes hanging down
It is provided with external screw thread on the straight gas inlet pipe 42 being arranged on the surface of cover plate, the outer surface of gas inlet pipe 42, gas the
The internal thread through hole being engaged with external screw thread is provided between one air inlet 41 and cylindricality cavity；Gas inlet pipe 42 and cylindricality are recessed
Chamber is coaxial, and the end of gas inlet pipe 42 is evenly arranged with multiple ventholes 43.The aperture of static pressure chamber outlet 45 can pass through gas
The screw-in depth of body air inlet pipe 42 is adjusted.
In use, the aerosol in first segment exposure chamber 11 passes through the outer surface of front piece 46 and the inwall of inner cylinder 101
Between space second section exposure chamber 12 is entered by first segment exposure chamber 11, air is entered by air compressor machine, gas inlet pipe 2
Venthole 43 of the first air inlet of gas 41 through being uniformly arranged is entered in first gas static pressure chamber 44, then by the outlet of static pressure chamber
45, second section exposure chamber 12 is entered after at static pressure chamber outlet 45 uniformly mix, to dilute aerosol, makes first segment sudden and violent
The aerosol concentration revealed in room 11 is different with aerosol concentration in second section exposure chamber 12.The outlet of static pressure chamber is quiet to be arranged on gas
The gap for the circumference adjustable size free of discontinuities that cavity wall and the bottom surface of chamber formed is pressed, makes to enter gas at mixing evenly,
More stable, the concentration of mixing or dilution effect more preferably, after mixing or dilution is stable, is evenly distributed.By internally setting
One gas passage, sets the second substance channel in outside, makes structure simpler, and mixing or dilution device volume are smaller, more practical.
Being connected through a screw thread makes the adjustable of gap width, to adjust first gas inlet, is easy to be applied to a variety of occasions, a variety of dilutions
Concentration.
As shown in Figure 5, Figure 6, step, first are provided with the two ends of the barrel of the inner cylinder 101 of first segment exposure chamber 11
The step at end and the step at the second end are used cooperatively, and are easy to large-scale production.First end step it is same with the inwall of inner cylinder
Set fluted on the face of axle, sealing ring is installed thereon, for preventing gas leakage.Equally, in the outer barrel of first segment exposure chamber 11
The two ends of 102 barrel are again provided with step and groove.12 experiments can be installed in the periphery of first segment exposure chamber 11 dynamic
Thing fixator 6.12 animals can be tested simultaneously.
In another embodiment of the presently claimed invention, experimental group exposure chamber 1 also includes Section of four exposure chamber and/or Section five
Exposure chamber.Experimental group exposure chamber includes more piece exposure chamber, is respectively provided with concentration dilution device 4 between every section exposure chamber, can use simultaneously
In multiple experiments, and aerosol can be used continuously, save sample, improve the utilization rate and service efficiency of aerosol.
In another embodiment of the presently claimed invention, concentration dilution device 4 is also equipped with the first aerosol import 111,
Make the uniform concentration distribution in first segment exposure chamber 11, further meet requirement of experiment.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, any improvements and modifications made also should be regarded as the protection of the present invention
Scope.
Claims (10)
1. a kind of many dynamic exposure units of concentration animal mouth and nose suction, including experimental group exposure chamber (1), it is characterised in that described
Experimental group exposure chamber (1) includes first segment exposure chamber (11) and second section exposure chamber (12)；In the first segment exposure chamber (11)
It is additionally provided between the second section exposure chamber (12) sudden and violent to entering the second section by the first segment exposure chamber (11)
The aerosol processing unit that aerosol in dew room (12) is diluted；The aerosol processing unit is additionally operable to make to enter institute
State uniform concentration distribution of the aerosol in the second section exposure chamber (12) in second section exposure chamber (12).
2. many dynamic exposure units of concentration animal mouth and nose suction according to claim 1, it is characterised in that the aerosol
Processing unit is concentration dilution device (4), and the concentration dilution device (4) is arranged on the first segment exposure chamber (11) and described second
Save between exposure chamber (12), the first segment exposure chamber (11) and the second section exposure chamber (12) pass through the concentration dilution device
(4) it is connected.
3. many dynamic exposure units of concentration animal mouth and nose suction according to claim 2, it is characterised in that the experimental group
Exposure chamber (1) also includes Section of three exposure chamber (13), the second section exposure chamber (12) and Section of three exposure chamber (13) it
Between be provided with the concentration dilution device (4).
4. many dynamic exposure units of concentration animal mouth and nose suction according to claim 2, it is characterised in that also including exposure
Unit base (3), fixing device for experimental animal (6) and control group exposure chamber (5)；The control group exposure chamber (5) is arranged on described
The top of experimental group exposure chamber (1)；The fixing device for experimental animal (6) is arranged on the experimental group exposure chamber (1) and control group
The periphery of exposure chamber (5).
5. the dynamic exposure unit of many concentration animal mouth and nose suction according to any one of claim 2-4, it is characterised in that
The experimental group exposure chamber (1) includes inner cylinder (101) and outer barrel (102)；
The concentration dilution device (4) is arranged in the inner cylinder (101)；
The first end of the inner cylinder (101) is provided with the first aerosol import (111), in use, the second of the inner cylinder (101)
End seal is closed；
The first end closing of the outer barrel (102), the second end of the outer barrel (102) is provided with passage；
The connecting tube (15) with the intracavity inter-connection of the fixing device for experimental animal (6) is provided with the inner cylinder (101), it is described
The intracavity inter-connection of outer barrel (102) and the fixing device for experimental animal (6).
6. many dynamic exposure units of concentration animal mouth and nose suction according to claim 4, it is characterised in that the experimental group
Exposure chamber (1) can rotate relative to the exposure unit base (3).
7. many dynamic exposure units of concentration animal mouth and nose suction according to claim 5, it is characterised in that the inner cylinder
(101) gas inlet pipe (2) is also set up on.
8. many dynamic exposure units of concentration animal mouth and nose suction according to claim 7, it is characterised in that the concentration is dilute
Releasing device (4) includes front piece (46), middle member (47) and back member (48)；
The air inlet of gas first (41) is provided with the front piece (46), is connected with the gas inlet pipe (2)；
Cylindricality cavity is offered in the rear end of the middle member (47), the back member (48) includes being used to cover in the post
Cover plate at the opening of shape cavity；Cavity formation first gas static pressure chamber (44) between the cover plate and the cylindricality cavity,
The opening place of the cover plate and the cylindricality cavity plane between there is gap, the gap is the outlet of static pressure chamber
(45)；
The back member (48) also includes the gas inlet pipe (42) being vertically set on the surface of the cover plate, the gas
External screw thread is provided with the outer surface of air inlet pipe (42), is set between the air inlet of gas first (41) and the cylindricality cavity
There is the internal thread through hole being engaged with the external screw thread；The end of the gas inlet pipe (42) is evenly arranged with multiple ventholes
(43)。
9. many dynamic exposure units of concentration animal mouth and nose suction according to claim 7, it is characterised in that the concentration is dilute
Releasing device (4) includes second gas static pressure chamber (405), mixing induction tunnel (406) and hybrid chamber (407) and the second matter inlet
(403), the first end of the mixing induction tunnel (406) is the first matter inlet (401), the of the mixing induction tunnel (406)
Two ends are connected with the hybrid chamber (407)；Second matter inlet (403) is to be arranged on the mixing induction tunnel (406)
Tube wall on gap, the gap is formed by the first face and the second face being parallel to each other；The second gas static pressure chamber (405)
For annular housing, the periphery of the mixing induction tunnel (406) is arranged on, the second gas static pressure chamber (405) passes through described the
Two matter inlets (403) are connected with the mixing induction tunnel (406), and gas is provided with the second gas static pressure chamber (405)
Body import (402).
10. many dynamic exposure units of concentration animal mouth and nose suction according to claim 9, it is characterised in that described first
Face is circular conical surface, the circular conical surface with described to mix induction tunnel (406) coaxial.
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| US5297502A (en) * | 1993-05-05 | 1994-03-29 | Jaeger Rudolf J | Modular reversible-flow-past nasopulmonary respiratory dosing system for laboratory animals |
| US9180263B2 (en) * | 2009-07-01 | 2015-11-10 | Microdose Therapeutx, Inc. | Laboratory animal pulmonary dosing device |
| CN101803962B (en) * | 2010-04-23 | 2011-10-05 | 中国人民解放军军事医学科学院微生物流行病研究所 | A rodent oronasal inhalation dynamic exposure device |
| CN203432980U (en) * | 2013-08-13 | 2014-02-12 | 北京慧荣和科技有限公司 | Multi-concentration animal oral-nasal inhalation dynamic exposure unit |
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