CN104288286B - A kind of pharmaceutical composition containing Radix Rhei emodi, extract solution and its application - Google Patents
A kind of pharmaceutical composition containing Radix Rhei emodi, extract solution and its application Download PDFInfo
- Publication number
- CN104288286B CN104288286B CN201410484798.1A CN201410484798A CN104288286B CN 104288286 B CN104288286 B CN 104288286B CN 201410484798 A CN201410484798 A CN 201410484798A CN 104288286 B CN104288286 B CN 104288286B
- Authority
- CN
- China
- Prior art keywords
- parts
- extract solution
- radix rhei
- rhei emodi
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 15
- -1 stilbene compound Chemical class 0.000 claims abstract description 13
- 241000219784 Sophora Species 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 7
- 241001165494 Rhodiola Species 0.000 claims abstract description 7
- 241000689249 Saussurea obvallata Species 0.000 claims abstract description 7
- 240000003705 Senecio vulgaris Species 0.000 claims abstract description 7
- 230000009194 climbing Effects 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000001914 filtration Methods 0.000 claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 18
- 239000011265 semifinished product Substances 0.000 claims description 16
- 239000004094 surface-active agent Substances 0.000 claims description 14
- 239000012153 distilled water Substances 0.000 claims description 13
- 238000000605 extraction Methods 0.000 claims description 13
- 238000010438 heat treatment Methods 0.000 claims description 12
- 239000003755 preservative agent Substances 0.000 claims description 12
- 230000002335 preservative effect Effects 0.000 claims description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 239000003599 detergent Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 6
- 238000004440 column chromatography Methods 0.000 claims description 6
- 239000003480 eluent Substances 0.000 claims description 6
- 238000010828 elution Methods 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000006260 foam Substances 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000002453 shampoo Substances 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 208000001840 Dandruff Diseases 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 229940043237 diethanolamine Drugs 0.000 claims description 4
- 235000019197 fats Nutrition 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 claims description 3
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 239000004594 Masterbatch (MB) Substances 0.000 claims description 3
- OTGQIQQTPXJQRG-UHFFFAOYSA-N N-(octadecanoyl)ethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCO OTGQIQQTPXJQRG-UHFFFAOYSA-N 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 239000003463 adsorbent Substances 0.000 claims description 3
- 229960003344 climbazole Drugs 0.000 claims description 3
- 235000019864 coconut oil Nutrition 0.000 claims description 3
- 239000003240 coconut oil Substances 0.000 claims description 3
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 3
- 229910001562 pearlite Inorganic materials 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000002002 slurry Substances 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 230000008719 thickening Effects 0.000 claims description 3
- 238000005491 wire drawing Methods 0.000 claims description 3
- RZRILSWMGXWSJY-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;sulfuric acid Chemical compound OS(O)(=O)=O.OCCN(CCO)CCO RZRILSWMGXWSJY-UHFFFAOYSA-N 0.000 claims description 2
- CGBXSWXZXBQCMR-UHFFFAOYSA-N Glycerol 1-hexadecanoate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O CGBXSWXZXBQCMR-UHFFFAOYSA-N 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000005323 thioketone group Chemical group 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 18
- 239000000126 substance Substances 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 14
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 abstract description 6
- 235000021286 stilbenes Nutrition 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical group C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- HDWLUGYOLUHEMN-UHFFFAOYSA-N Dinobuton Chemical compound CCC(C)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1OC(=O)OC(C)C HDWLUGYOLUHEMN-UHFFFAOYSA-N 0.000 description 2
- 241000425573 Talanes Species 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000003287 bathing Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 150000002169 ethanolamines Chemical class 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 244000089742 Citrus aurantifolia Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 241001573881 Corolla Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- PVNIQBQSYATKKL-UHFFFAOYSA-N Glycerol trihexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 1
- 241000218228 Humulus Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 244000042430 Rhodiola rosea Species 0.000 description 1
- 235000003713 Rhodiola rosea Nutrition 0.000 description 1
- 235000014327 Sedum acre Nutrition 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 241001398492 Sophora moorcroftiana Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000001572 anti-trichomonad Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- PGRLPHKGHMCNGH-UHFFFAOYSA-N dodecanoic acid ethanol Chemical compound CCO.CCO.CCCCCCCCCCCC(O)=O PGRLPHKGHMCNGH-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229940048842 sodium xylenesulfonate Drugs 0.000 description 1
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/83—Mixtures of non-ionic with anionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a kind of pharmaceutical composition containing Radix Rhei emodi, composition extracting method and its extract solution, composition includes 60 parts of Radix Rhei emodi, 15 parts of sandliving sophora seed, 10 parts of Saus-surea obvallata (DC.) Edgew, 8 parts of rhodiola root, 5 parts of oldenlandia diffusa, 2 parts of climbing groundsel；The present invention also provides application said extracted daily chemical product prepared by liquid, preparation method.Pharmaceutical composition containing Radix Rhei emodi of the invention, extract solution and its daily use chemicals sterile products of preparation, the stilbene compound enriched using containing in Radix Rhei emodi, its extensive bioactivity having, good bactericidal effect, a kind of serial daily chemical products of Radix Rhei emodi efficiently, safe are provided for people, other raw materials added further increase effect of Radix Rhei emodi, and with synergistic function, preparation method is simple and easy to do, safe and efficient.
Description
Technical field
The present invention relates to sterilization daily use chemicals cleaning products and preparation method thereof, more particularly to a kind of drug regimen containing Radix Rhei emodi
Thing and its extract solution, and application of the extract solution in the serial daily chemical products such as sterilization, bathing.
Background technology
Radix Rhei emodi system polygonaceae Rheum ripple leaf group plant Radix Rhei emodi RheumemodiWall. root and rhizome, sour,
Hardship, it is cold in nature；The provinces and regions such as the Tibet central and east, Qinghai, Sichuan, Yunnan are mainly distributed on, mostly wild, there is kind Tibet some areas
Plant；Hide, Mongolian medicine is used to treat gastroenteritis, ephritis, external application stops blooding, controls sore, anti-inflammatory, callus mouthful etc..The chemical composition of Radix Rhei emodi
Mainly there are Anthraquinones, diphenylethylene and tannins.Containing abundant stilbene compound in Radix Rhei emodi, there is text at present
Offering report, it has preferable hypoglycemic effect, it has also become study hotspot.Stilbene class (stilbene) is with talan parent nucleus
Or a class material general name of its polymer, it has extensive bioactivity, except the antibacterial action having long been known that, sends out again in recent years
Existing reducing blood lipid, hypoglycemic, liver protection, expansion capillary improve microcirculation, the expansion effect such as coronary vasodilator and decompression.Hide side big
Contain more tannin in Huang, there are a variety of pharmacological effects, renal function, antiviral, anticoagulation can be improved, mental disease can be treated, controlled
Treat the diseases such as gastrorrhagia.
Containing abundant stilbene compound in Radix Rhei emodi, stilbene class (stilbene) is with talan parent nucleus or it is poly-
One class material general name of compound, it has extensive bioactivity, pure with well developing into the effect of good bactericidal
The potential quality of natural daily use chemicals cleaning products.Do not have been reported that at present and apply Radix Rhei emodi in the daily chemical products such as sterilization, bathing.
Sandliving sophora seed (Sophora moorcroftiana) belongs to pulse family Sophora, is short and the shrub of racemosus, close short soft by white
Hair, sprig top is into thorn-like.Odd number winglike compound leaf, leaflet 11~17, ellipse to ovate-elliptic, tip has long puncture tip, two
Face is by white long pubescence；Stipule is harbored, in needle prick shape.Raceme axillary or basidixed, many and scattered, corolla bluish violet, vexil
Bottom white.Sandliving sophora seed soft texture, slightly bitter taste, with heat-clearing, the effect of removing toxic substances.
Saus-surea obvallata (DC.) Edgew (Saussurea obvallata (DC.) Edgew.) is feverfew, distribution Gansu, Qinghai, four
The ground such as river, Yunnan, Tibet.With clearing heat and detoxicating, dispelling wind and eliminating dampness, restore menstrual flow and invigorate blood circulation the effects such as.
Rhodiola root (Rhodiola rosea) is the plant of Crassulaceae rhodiola.It is grown in height above sea level 800 --- 2500 meters
The rare wild plant of high and cold contamination-freely band.Because its growing environment is severe, such as anoxic, low temperature drying, blast, by ultraviolet
Irradiation, day and night temperature are big, thus with very strong vitality and special adaptability.Stop with antibacterial, promoting blood circulation and hemostasis, clearing lung-heat
Cough, change silt detumescence, antipyretic bring down a fever, nourish vigour, treating traumatic injury and the effects such as burn and scald.
Oldenlandia diffusa (Hedyotis diffusa) also known as：Two leaf humulus.It is annual to hang down loosely draft, high 15-50cm.Distribution
The ground such as Yunnan, Guangdong, Guangxi, Fujian, Zhejiang, Jiangsu, Anhui.Because consumption is big, wild resource is reduced, and preferably appropriate development is artificial
Cultivation, meets medication needs.Main product is in provinces and regions such as Fujian, Guangdong, Guangxi, Yunnan, Zhejiang, Jiangsu, Anhui.It is born in the field of humidity
Side, limes marginis, roadside and meadow.With the effect such as anti-inflammation, antitumor
Climbing groundsel, alias nine inner bright, Broomjutre Sida Herb, Kowloon light, nine ridge light.For feverfew climbing groundsel
SenecioscandensBuch ,-Ham. aerial part.Perennial herb, climbs up by holding on to shape woody stems, and high 1~5m has microtriche,
After come off.With the effect such as antibacterial, anti-conveyor screw, anti-trichomonal.
The content of the invention
The present invention discloses a kind of pharmaceutical composition containing Radix Rhei emodi, extract solution according to the deficiencies in the prior art and its answered
With.It is an object of the present invention to provide a kind of pharmaceutical composition containing Radix Rhei emodi, composition extracting method and its extract solution, the present invention is also
Application said extracted daily chemical product prepared by liquid, preparation method are provided, a kind of Radix Rhei emodi system efficiently, safe is provided for people
Row daily chemical products.
The present invention is achieved through the following technical solutions.
Present invention firstly provides a kind of composition containing Radix Rhei emodi：
Pharmaceutical composition containing Radix Rhei emodi, it is characterized in that：Described pharmaceutical composition by following parts by weight raw material group
Into：60 parts of Radix Rhei emodi, 15 parts of sandliving sophora seed, 10 parts of Saus-surea obvallata (DC.) Edgew, 8 parts of rhodiola root, 5 parts of oldenlandia diffusa, 2 parts of climbing groundsel.
Present invention also offers the extract solution and its extracting method of the above-mentioned pharmaceutical composition containing Radix Rhei emodi：
The extract solution of the pharmaceutical composition containing Radix Rhei emodi, it is characterized in that being prepared by following methods：
The raw material of the above-mentioned parts by weight of pharmaceutical composition containing Radix Rhei emodi of the invention is weighed respectively, using following (1) to (5)
It is prepared by any method：
(1) fresh, dry feedstock is added into water or dilute alcohol, heating extraction, extract solution filtration is concentrated, dried, obtain half into
Product；
(2) fresh, dry feedstock is added into water or dilute alcohol, heating extraction, extract solution filtration, filtrate passes through macroporous absorption tree
Fat column chromatography, is washed with water cylinder, discards water lotion, then with 10%~90% ethanol elution, eluent filtration is concentrated, dried,
Obtain semi-finished product；
(3) fresh feed is obtained into pressed liquor and press residue through squeezing, pressed liquor filtration, filtrate concentration is dried, obtain half into
Product；
(4) fresh feed is obtained into pressed liquor and press residue through squeezing, press residue adds water or dilute alcohol, heating extraction, extracted
Liquid and pressed liquor merge, and filter, and concentrate, and dry, obtain semi-finished product；
(5) fresh feed is obtained into pressed liquor and press residue through squeezing, press residue adds water or dilute alcohol, heating extraction, extracted
Liquid and pressed liquor merge, and filtration, filtrate is washed with water cylinder by macroporous adsorbent resin column chromatography, discards water lotion, then use
10%~90% ethanol elution, eluent filtration, is concentrated, and is dried, is obtained semi-finished product；
Semi-finished product weight percent content 50~80% is pressed, takes any of the above-described semi-finished product to be diluted with water, shakes up, stands, takes
Supernatant, filtration adds the Tween 80 of percentage by weight 1% and the glycerine of percentage by weight 1%, shaken up, and packing is combined
Thing extract solution.
Present invention also offers preparation and its application of the said extracted liquid in daily chemical products, including shampoo, hand cleanser,
The preparation and its application of bath foam and liquid detergent.
A kind of shampoo containing above-mentioned Radix Rhei emodi pharmaceutical composition extract solution；
The shampoo is made up of the raw material of following parts by weight：2~4 parts of extract solution, flexible abstergent core master batch 2~
4 parts, 10~20 parts of surfactant, 5~10 parts of anti-dandruff agent, 0.3~1 part of pearlite slurry, 1~3 part of sodium chloride, preservative 0.1~
0.5 part, 0.5~1 part of natural essence, 0.1~0.5 part of wire drawing powder, surplus is distilled water, and each component summation is 100 parts；
The surfactant is ethoxylated dodecyl alcohol mono sulfosuccinates, cocamidopropyl propyl amide beet
Alkali, moon silicic acid Dialvcolovl amine, stearic acid monoethanolamide, the one or more of the ethanol of lauryl alcohol sulfuric acid three；Anti-dandruff agent is
One or more in ZPT, active climbazole, hydroxymethylpyridine ketone ethanolamine salt.
A kind of hand cleanser containing above-mentioned Radix Rhei emodi pharmaceutical composition extract solution；
The hand cleanser is made up of the raw material of following parts by weight：2~8 parts of extract solution, NaCl1~6 part, surfactant
(AES) 20~60 parts, all-round 0.5~2.5 part of emulsifying agent, 0.5~2 part of AES companions thickener, 3~10 parts of NMF, natural perfume
0.1~0.8 part of essence, 3~6 parts of coconut oil diethanol amine, 0.5~1 part of thickening powder, 0.3~0.7 part of preservative, pigment 0.5~1
Part, surplus is distilled water, and each component summation is 100 parts；
The surfactant is a kind in dodecyl sodium sulfate, alkylpolyoxyethylene amine sulfate, NMF
For the one or more in glycerine, ethylene glycol, sorbierite, propane diols.
A kind of bath foam containing above-mentioned Radix Rhei emodi pharmaceutical composition extract solution；
The bath foam is made up of the raw material of following parts by weight：3~5 parts of extract solution, 30~40 parts of surfactant is protected
10~15 parts of humectant, 1~3 part of natural essence, 0.2~0.5 part of preservative, surplus is distilled water, and each component summation is 100 parts；
The surfactant is lauryl alcohol sulfuric acid triethanolamine salt, ether alcohol sulfate, the one of lauroyl diglycollic amide
Plant or several；NMF is glycerine palmitate, glycerine, the one or more of propane diols.
A kind of liquid detergent containing above-mentioned Radix Rhei emodi pharmaceutical composition extract solution；
The liquid detergent is made up of the raw material of following parts by weight：1~5 part of extract solution, surfactant (AES) 20~60
Part, 2~5 parts of sodium chloride, 0.5~1.5 part of essence, all-round 1~3 part of emulsifying agent, 0.5~1 part of AES companions thickener, essence 0.5
~1.5 parts, 0.3~0.7 part of preservative, surplus is distilled water, and each component summation is 100 parts；
The surfactant is neopelex, alkylpolyoxyethylene amine sulfate, xylene monosulfonic acid
The one or more of sodium, fatty diglycollic amide.
Pharmaceutical composition containing Radix Rhei emodi of the invention mainly includes 60 parts of Radix Rhei emodi, 15 parts of sandliving sophora seed, Saus-surea obvallata (DC.) Edgew 10
Part, 8 parts of rhodiola root, 5 parts of oldenlandia diffusa, 2 parts of climbing groundsel, selected crude drug has anti-inflammation, clearing heat and detoxicating work(
Effect, while collaboration, cooperation in Radix Rhei emodi pharmaceutical composition between each medicine so that Radix Rhei emodi pharmaceutical composition is in antibacterial
It is not fully exerted in anti-inflammatory, clearing heat and detoxicating effect.
The extract solution of pharmaceutical composition containing Radix Rhei emodi of the invention has been effectively retained the anti-inflammation, clearing heat and detoxicating of composition
Effect, extraction preparation method is simple and easy to apply, safe and efficient, utilization rate is high.
Using extract solution of the present invention prepare each daily chemical product, after testing its there is good disinfection function, it is stingless
Swash property effect, the natural origin of raw material is that product has no toxic side effect, can effectively kill various pathogenic microorganisms, suppress bacterium life
It is long.
Pharmaceutical composition containing Radix Rhei emodi of the invention, extract solution and its daily use chemicals sterile products of preparation, utilize Radix Rhei emodi
In provide one kind containing abundant stilbene compound, its extensive bioactivity having, good bactericidal effect for people
Efficiently, the serial daily chemical products of safe Radix Rhei emodi, other raw materials of addition further increase effect of Radix Rhei emodi, had
Synergistic function, preparation method is simple and easy to do, safe and efficient.
Embodiment
The present invention is further described below by embodiment, embodiment is served only for carrying out further the present invention
Explanation, but it is not intended that limiting the scope of the invention, those skilled in the art can be according to the invention described above
Content make some nonessential modifications and adaptations and belong to the scope of protection of the invention.
Embodiment 1
It is prepared by the extract solution of the pharmaceutical composition containing Radix Rhei emodi：
Weigh each raw material of following parts by weight respectively, it is 60 parts of Radix Rhei emodi, 15 parts of sandliving sophora seed, 10 parts of Saus-surea obvallata (DC.) Edgew, red
8 parts of red-spotted stonecrop, 5 parts of oldenlandia diffusa, 2 parts of climbing groundsel, are prepared using any method in following (1) to (5)：
(1) fresh, dry feedstock is added into water or dilute alcohol, heating extraction, extract solution filtration is concentrated, dried, obtain half into
Product；
(2) fresh, dry feedstock is added into water or dilute alcohol, heating extraction, extract solution filtration, filtrate passes through macroporous absorption tree
Fat column chromatography, is washed with water cylinder, discards water lotion, then with 10%~90% ethanol elution, eluent filtration is concentrated, dried,
Obtain semi-finished product；
(3) fresh feed is obtained into pressed liquor and press residue through squeezing, pressed liquor filtration, filtrate concentration is dried, obtain half into
Product；
(4) fresh feed is obtained into pressed liquor and press residue through squeezing, press residue adds water or dilute alcohol, heating extraction, extracted
Liquid and pressed liquor merge, and filter, and concentrate, and dry, obtain semi-finished product；
(5) fresh feed is obtained into pressed liquor and press residue through squeezing, press residue adds water or dilute alcohol, heating extraction, extracted
Liquid and pressed liquor merge, and filtration, filtrate is washed with water cylinder by macroporous adsorbent resin column chromatography, discards water lotion, then use
10%~90% ethanol elution, eluent filtration, is concentrated, and is dried, is obtained semi-finished product；
Semi-finished product weight percent content 50~80% is pressed, takes any of the above-described semi-finished product to be diluted with water, shakes up, stands, takes
Supernatant, filtration adds the Tween 80 of percentage by weight 1% and the glycerine of percentage by weight 1%, shaken up, and packing is combined
Thing extract solution.
Embodiment 2
The preparation of shampoo
Each raw material of following parts by weight, 3 parts of the extract solution that embodiment 1 is prepared, flexible abstergent core are weighed respectively
3 parts of heart masterbatch, 4 parts of ethoxylated dodecyl alcohol mono sulfosuccinates, 2 parts of Cocoamidopropyl betaine, the moon silicon
Sour 3 parts of Dialvcolovl, 3 parts of stearic acid monoethanolamide, 3 parts of ZPT, active 2 parts of climbazole, hydroxymethylpyridine ketone
2 parts of ethanolamine salt, 0.5 part of pearlite slurry, 2 parts of sodium chloride, 0.3 part of preservative, 0.7 part of natural essence, 0.3 part of wire drawing powder, other
For distilled water, each component summation is 100 parts.
Preparation method：Distilled water is heated to 45 DEG C, each material is slowly added in water successively, after being uniformly mixed,
Cooling.It is cooled to after normal temperature and dispenses.
Embodiment 3：
The preparation of hand cleanser
Each raw material of following parts by weight, 5 parts of the extract solution that embodiment 1 is prepared, NaCl2 parts, 12 are weighed respectively
20 parts of sodium alkyl sulfonate, all-round 1 part of emulsifying agent, 1 part of AES companions thickener, 2 parts of glycerine, 1 part of ethylene glycol, 1 part of sorbierite, third
1 part of glycol, 0.5 part of natural essence, 4 parts of coconut oil diethanol amine, 0.6 part of thickening powder, 0.5 part of preservative, 0.7 part of pigment, its
He is distilled water, and each component summation is 100 parts.
Preparation method：Each component is added to the water, it is stirring while adding, 45 DEG C are heated to, is stirred.Dispensed after cooling
Into bottle.
Embodiment 4：
The preparation of bath foam
Each raw material of following parts by weight, 4 parts of the extract solution that embodiment 1 is prepared, lauryl alcohol sulfuric acid three are weighed respectively
20 parts of ethanolamine salt, 10 parts of ether alcohol sulfate (dissolving of 30% water), 5 parts of laurate diethanol amine, 2 parts of glycerine palmitin, sheep
3 parts of hair fat (water solubility), 1 part of propane diols, 2 parts of natural essence, 0.4 part of preservative, other are distilled water, and each component summation is
100 parts.
Preparation method：45 DEG C are heated water to, each component is added successively after being well mixed in container, is cooled to after normal temperature
Packing.
Embodiment 5：
The preparation of liquid detergent
Each raw material of following parts by weight, 4 parts of the extract solution that embodiment 1 is prepared, detergent alkylate sulphur are weighed respectively
Sour (60%) 20 part of sodium, 2 parts of fatty diglycollic amide, (40%) 10 part of sodium xylene sulfonate, all-round 2 parts of emulsifying agent, AES companions
1 part of companion's thickener, 4 parts of sodium chloride, 1 part of natural essence, 0.5 part of preservative, other are distilled water, and each component summation is 100 parts.
Preparation method：45 DEG C are heated water to, each component is added successively after being well mixed in container, is cooled to after normal temperature
Packing.
Detect example
Sample obtained by embodiment 2, embodiment 3, embodiment 4, embodiment 5 is subjected to bacterium, mould detection, specifically
Embodiment is as follows：
Inoculum concentration be 1.0ml/100ml samples, bacterial concentration be 6.3 × 108cfu/ml, mold concentrations be 8.8 ×
108cfu/ml。
Through experiment, the measure of strain quantity, measurement result such as following table are carried out in an aseptic environment：
The results showed, there is each daily chemical products in the present invention good bactericidal to act on.
Claims (6)
1. a kind of pharmaceutical composition containing Radix Rhei emodi, it is characterized in that：Described pharmaceutical composition by following parts by weight raw material
Composition：60 parts of Radix Rhei emodi, 15 parts of sandliving sophora seed, 10 parts of Saus-surea obvallata (DC.) Edgew, 8 parts of rhodiola root, 5 parts of oldenlandia diffusa, 2 parts of climbing groundsel.
2. the extract solution of a kind of pharmaceutical composition containing Radix Rhei emodi, it is characterized in that being prepared by following methods：
The raw material of parts by weight described in claim 1 is weighed respectively, is prepared using any method in following (1) to (5)：
(1) fresh, dry feedstock is added into water or dilute alcohol, heating extraction, extract solution filtration concentrates, dries, obtain semi-finished product；
Or, fresh, dry feedstock is added water or dilute alcohol by (2), heating extraction, extract solution filtration, filtrate passes through macroporous absorption tree
Fat column chromatography, is washed with water cylinder, discards water lotion, then with 10%~90% ethanol elution, eluent filtration is concentrated, dried,
Obtain semi-finished product；
Or, fresh feed is obtained pressed liquor and press residue by (3) through squeezing, pressed liquor filtration, filtrate concentration is dried, obtain half into
Product；
Or, fresh feed is obtained pressed liquor and press residue by (4) through squeezing, press residue adds water or dilute alcohol, heating extraction, extract solution
Merge with pressed liquor, filter, concentrate, dry, obtain semi-finished product；
Or, fresh feed is obtained pressed liquor and press residue by (5) through squeezing, press residue adds water or dilute alcohol, heating extraction, extract solution
Merge with pressed liquor, filtration, cylinder is washed with water by macroporous adsorbent resin column chromatography in filtrate, discard water lotion, then with 10%
~90% ethanol elution, eluent filtration, is concentrated, and is dried, is obtained semi-finished product；
Semi-finished product weight percent content 50~80% is pressed, takes any of the above-described semi-finished product to be diluted with water, shakes up, stands, takes supernatant
Liquid, filtration adds the Tween 80 of percentage by weight 1% and the glycerine of percentage by weight 1%, shaken up, and packing obtains composition and carried
Take liquid.
3. a kind of shampoo containing Radix Rhei emodi pharmaceutical composition extract solution described in claim 2, it is characterized in that：
The shampoo is made up of the raw material of following parts by weight：2~4 parts of extract solution, 2~4 parts of flexible abstergent core master batch,
10~20 parts of surfactant, 5~10 parts of anti-dandruff agent, 0.3~1 part of pearlite slurry, 1~3 part of sodium chloride, preservative 0.1~0.5
Part, 0.5~1 part of natural essence, 0.1~0.5 part of wire drawing powder, surplus is distilled water, and each component summation is 100 parts；
The surfactant be ethoxylated dodecyl alcohol mono sulfosuccinates, Cocoamidopropyl betaine,
Month silicic acid Dialvcolovl amine, stearic acid monoethanolamide, the one or more of the ethanol of lauryl alcohol sulfuric acid three；Anti-dandruff agent is pyridine
One or more in thioketones zinc, active climbazole, hydroxymethylpyridine ketone ethanolamine salt.
4. a kind of hand cleanser containing Radix Rhei emodi pharmaceutical composition extract solution described in claim 2, it is characterized in that：
The hand cleanser is made up of the raw material of following parts by weight：2~8 parts of extract solution, NaCl1~6 part, surfactant
AES20~60 part, 0.5~2.5 part of emulsifying agent, 0.5~2 part of AES companions thickener, 3~10 parts of NMF, natural essence 0.1
~0.8 part, 3~6 parts of coconut oil diethanol amine, 0.5~1 part of thickening powder, 0.3~0.7 part of preservative, 0.5~1 part of pigment is remaining
Measure as distilled water, each component summation is 100 parts；
NMF is the one or more in glycerine, ethylene glycol, sorbierite, propane diols.
5. a kind of bath foam containing Radix Rhei emodi pharmaceutical composition extract solution described in claim 2, it is characterized in that：
The bath foam is made up of the raw material of following parts by weight：3~5 parts of extract solution, 30~40 parts of surfactant, NMF
10~15 parts, 1~3 part of natural essence, 0.2~0.5 part of preservative, surplus is distilled water, and each component summation is 100 parts；
The surfactant be lauryl alcohol sulfuric acid triethanolamine salt, ether alcohol sulfate, one kind of lauroyl diglycollic amide or
It is several；NMF is glycerine palmitate, glycerine, the one or more of propane diols.
6. a kind of liquid detergent containing Radix Rhei emodi pharmaceutical composition extract solution described in claim 2, it is characterized in that：
The liquid detergent is made up of the raw material of following parts by weight：1~5 part of extract solution, surfactant A ES20~60 part, chlorine
2~5 parts of sodium of change, 0.5~1.5 part of essence, 1~3 part of emulsifying agent, 0.5~1 part of AES companions thickener, 0.5~1.5 part of essence,
0.3~0.7 part of preservative, surplus is distilled water, and each component summation is 100 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410484798.1A CN104288286B (en) | 2014-09-19 | 2014-09-19 | A kind of pharmaceutical composition containing Radix Rhei emodi, extract solution and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410484798.1A CN104288286B (en) | 2014-09-19 | 2014-09-19 | A kind of pharmaceutical composition containing Radix Rhei emodi, extract solution and its application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104288286A CN104288286A (en) | 2015-01-21 |
| CN104288286B true CN104288286B (en) | 2017-09-12 |
Family
ID=52308398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410484798.1A Active CN104288286B (en) | 2014-09-19 | 2014-09-19 | A kind of pharmaceutical composition containing Radix Rhei emodi, extract solution and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104288286B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055199B (en) * | 2015-06-30 | 2018-03-27 | 广州环亚化妆品科技有限公司 | A kind of gentle desquamation compositions and its preparation method and application |
| DE102016116126A1 (en) * | 2016-08-30 | 2018-03-01 | SjF Hanse Scientific UG (haftungsbeschränkt) | An antibacterial composition comprising a plant extract, a process for obtaining the extract, a pharmaceutical composition and the use thereof |
| CN107308223A (en) * | 2017-07-10 | 2017-11-03 | 西藏月王藏药科技有限公司 | With Tibetan medicinal composition of the bacteriostasis containing highland barley monascus, preparation and its application |
| CN115645451B (en) * | 2022-11-09 | 2024-02-06 | 四川智谷藏御堂生物科技有限责任公司 | Tibet bath composition, tibetan bath medicament, preparation method and use method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788627A (en) * | 2005-12-16 | 2006-06-21 | 吕坤秋 | Highland barley healthcare drink and preparation method thereof |
| CN1799427A (en) * | 2006-01-19 | 2006-07-12 | 拉萨乌孜食品饮料发展有限公司 | Rheumefmodiwdll extract and its application |
| CN1911045A (en) * | 2005-08-10 | 2007-02-14 | 兰州大学 | Bacteriostat and insecticide contg. extraction of silicicole pagoda-tree, and its prepn. method |
| CN102106889A (en) * | 2011-02-21 | 2011-06-29 | 贾正平 | Application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and method for preparing snow saussurea extract |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1506090A (en) * | 2002-12-06 | 2004-06-23 | 李玉峰 | Rheum emodi wall extract and medicine composition with the extract as active component |
| CN1548034A (en) * | 2003-05-21 | 2004-11-24 | 哈药集团三精制药有限公司 | Sahuanglian skin care washing article |
| CN102772501A (en) * | 2011-05-13 | 2012-11-14 | 西藏金哈达药业有限公司 | Rheum emodi Wall. extract and its preparing method |
| CN102525857B (en) * | 2012-01-18 | 2013-04-03 | 李军 | Hand wash for disinfection and sterilization |
| CN103725445A (en) * | 2013-12-10 | 2014-04-16 | 芜湖华海生物工程有限公司 | Allantoin-containing non-residue traditional Chinese medicine washing-up liquid |
-
2014
- 2014-09-19 CN CN201410484798.1A patent/CN104288286B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911045A (en) * | 2005-08-10 | 2007-02-14 | 兰州大学 | Bacteriostat and insecticide contg. extraction of silicicole pagoda-tree, and its prepn. method |
| CN1788627A (en) * | 2005-12-16 | 2006-06-21 | 吕坤秋 | Highland barley healthcare drink and preparation method thereof |
| CN1799427A (en) * | 2006-01-19 | 2006-07-12 | 拉萨乌孜食品饮料发展有限公司 | Rheumefmodiwdll extract and its application |
| CN102106889A (en) * | 2011-02-21 | 2011-06-29 | 贾正平 | Application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and method for preparing snow saussurea extract |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104288286A (en) | 2015-01-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103520053B (en) | Hair and body bathing powder | |
| CN102670443A (en) | Plant whitening skin-changing product and preparation process thereof | |
| CN104288286B (en) | A kind of pharmaceutical composition containing Radix Rhei emodi, extract solution and its application | |
| CN100536825C (en) | A shampoo containing snake gallbladder and Chinese herbal medicine | |
| CN105998195A (en) | Cannabis extract with anti-sensitive and moisture retention functions and application thereof | |
| CN101732224A (en) | Shampoo containing snake gall, olive oil and Chinese herbs | |
| CN108852951A (en) | A kind of moistening and cleaning skin composition and plant body wash | |
| CN107739670A (en) | A kind of Eucommia Oil perfumed soap and preparation method thereof | |
| CN105496830A (en) | Preparation method of alpinia japonica extract and application thereof in personal care products | |
| CN110669598A (en) | Traditional Chinese medicine shampoo soap and preparation method thereof | |
| CN110037958A (en) | A kind of pox-eliminating whitening moisture saver mask of the ingredient containing trollflower and preparation method thereof | |
| CN105919894A (en) | Biological environment-friendly liquid shampoo and preparing method thereof | |
| CN109010193A (en) | A kind of Pudilan shower cream and preparation method thereof | |
| CN106635563A (en) | Weak acid crystal soap for skin health and purification | |
| CN105326689A (en) | Preparing method for traditional Chinese medicine dandruff-removing shampoo | |
| CN104367502A (en) | Plant composition extracting solution as well as extraction method and application thereof | |
| CN104083297A (en) | Preparation method and product thereof of Chinese herbal medicine whitening sunscreen skin cream | |
| CN107213062A (en) | A kind of fair-skinned bright white mildy wash and preparation method thereof | |
| CN106974858A (en) | A kind of acne-removing composition of Sage Extract and its application | |
| CN103284896A (en) | Willow-leaved wintersweet bactericidal hand sanitizer and preparation method thereof | |
| JP2004018492A (en) | Histamine release inhibitor, antiallergic agent and cosmetic composition | |
| CN110755322A (en) | Jindan anti-allergy traditional Chinese medicine extract and preparation method and application thereof | |
| CN108186440A (en) | Can antibiotic skin-care Chinese medicinal plant shower cream and its preparation method and application | |
| CN103284903A (en) | Preparation method of vinyl laurate skincare liquid | |
| CN105326726B (en) | A kind of bamboo juice toner and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |