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CN104287964A - Double-layer medical infusion bottle and manufacturing method thereof - Google Patents

Double-layer medical infusion bottle and manufacturing method thereof Download PDF

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Publication number
CN104287964A
CN104287964A CN201410527056.2A CN201410527056A CN104287964A CN 104287964 A CN104287964 A CN 104287964A CN 201410527056 A CN201410527056 A CN 201410527056A CN 104287964 A CN104287964 A CN 104287964A
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CN
China
Prior art keywords
double
bottle
infusion bottle
blowing
internal layer
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Pending
Application number
CN201410527056.2A
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Chinese (zh)
Inventor
董春浩
曹宗培
吴涛
陈芽
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China Resources Double Crane Pharmaceutical Co Ltd
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China Resources Double Crane Pharmaceutical Co Ltd
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Priority to CN201410527056.2A priority Critical patent/CN104287964A/en
Publication of CN104287964A publication Critical patent/CN104287964A/en
Pending legal-status Critical Current

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  • Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)

Abstract

The invention discloses a double-layer medical infusion bottle and a manufacturing method thereof. The double-layer medical infusion bottle comprises a double-layer flat infusion bottle body, an inner layer made of polypropylene material and used for keeping infusion stability, and an outer layer made of ester type co-polymer material and capable of being directly used for printing labels. The infusion bottle is good in safety, good in barrier property and good in infusion performance. The manufacturing method for the double-layer medical infusion bottle includes that using a double-die head extrusion die to extrude in one die and blow air. The technique is simple and advanced, and the double-layer medical infusion bottle is formed in one die; the manufacturing method is suitable for the double-layer medical infusion bottle production, and the manufactured infusion bottle conforms to infusion requirements.

Description

A kind of double-deck medical infusion bottle and manufacture method thereof
Technical field
The present invention relates to the field of medical plastic packing container, particularly relate to a kind of can the double-deck medical infusion bottle of printed label and manufacture method thereof.
Background technology
At present, medical infusion plastic bottle has Polypropylene bottle and blended transfusion bag two type.Simply introduce content and its weak point of these two kinds of infusion vessels below:
Plain polypropylene plastic bottle, adopt notes stretch blow moulding process more, is applicable to the bottle that bottle wall is thin; This production technology characteristic, for stretch to pipe, causes bottle wall very thin, and especially to the bottle of flat, the large direction that stretches is thinner, and bottle wall thickness is thin seriously uneven.Oxygen and moisture-vapor transmission are comparatively large, can only pack common transfusion; Still there is the defect of vial in infusion model, need to pass into air in bottle, harmful antibacterial and microgranule enter, and thus cause the possibility that bottle inner liquid medicine pollutes, and plain polypropylene infusion bottle adopts the mode of pasting adhesive label simultaneously, adhesive label scribbles adhesive, containing large amount of organic matter on adhesive, the risk of oriented medicinal liquid migration, simultaneously, because the sterilizing after liquid drug and lamp inspection operation are without label, easily there is the risk of mixed medicine.Polypropylene material is direct colour print not easily.Therefore the development of plastic bottle is restricted.
Blend composition infusion bottle, as much adopts note stretch blow moulding process, and this production technology characteristic, for stretch to pipe, causes bottle wall very thin, and especially to the bottle of flat, the large direction that stretches is thinner, and bottle wall thickness is thin seriously uneven.Oxygen and moisture-vapor transmission larger, can only pack limited common transfusion, this infusion bottle, owing to adopting PP and styrene-ethylene/butylene-styrene block copolymer blending technology, makes polypropylene material hardness lower, tool, in use without the need to air inlet, adopts atmospheric pressure transfusion.Co-blend polypropylene infusion bottle adopts the mode of pasting adhesive label simultaneously, adhesive label scribbles adhesive, containing large amount of organic matter on adhesive, the risk of oriented medicinal liquid migration, simultaneously, because the sterilizing after liquid drug and lamp inspection operation are without label, easily there is the risk of mixed medicine, co-blend polypropylene material also not easily direct colour print.
Summary of the invention
The invention provides a kind of double-deck medical infusion bottle and manufacture method thereof, by arranging the infusion bottle of double bottle Rotating fields and providing corresponding production method, overcome PP or PP and the blended shortcoming of styrene-ethylene/butylene-styrene block copolymer, in conjunction with both advantage, and adopt the technique of extrusion blow more can play the performance of material, solve produced problem in background technology.
The object of this invention is to provide a kind of double-deck medical infusion bottle and manufacture method thereof, the transfusion bottle of a kind of medical infusion bottle mainly double-deck flat shape, transfusion bottle shoulder erects; Double-decker mainly polyacrylic internal layer keeps skin that is stable and lipin polymer to be easy to printed label; Be outside equipped with hanging ring in the middle of the bottom of transfusion bottle, the surrounding of the bottom hung ring of transfusion bottle arranges four feets.
Further improvement is: the polypropylene of internal layer and the mass ratio (60 ~ 80) of outer field lipin polymer: (20 ~ 40).
Further improvement is: skin can adopt high barrier material, for packing the oxidizable transfusion of aminoacid, fat milk and so on.
A manufacture method for double-deck medical infusion bottle, comprises the following steps:
Step one: by the barrel making the polypropylene material of internal layer, outer field lipin polymer material is respectively charged into the extrusion die of corresponding internal layer and outer field extruding and blowing machine;
Step 2: preheating is carried out to extruding and blowing machine and blowing mould, by step one material heating and melting respectively, temperature is 220 ~ 260 DEG C, after melting, is extruded respectively form the tubulose embryo that internal layer is polypropylene material, skin is lipin polymer material by two extrusion die heads of extruding and blowing machine;
Step 3: the tubulose embryo of bilayer step 3 formed sends into the interior shape bottle blowing mould identical with tubulose embryo, closes afterwards;
Step 4: remove the unnecessary tubulose embryo of blowing mould upper and lower with heating plate;
Step 5: tubulose embryo passes into compressed air and carries out bottle blowing in blowing mould, air blowing air pressure is 1.0 ~ 1.5MPa, and tubulose embryo cooling and shaping under air pressure after blowing, makes the infusion bottle of required bilayer;
Step 6: carry out punching bottom the infusion bottle of bilayer step 5 obtained, makes link.
Step 7: the infusion bottle of bilayer step 6 obtained carries out printed label.
Further improvement is: the polypropylene of described internal layer and the mass ratio (60 ~ 80) of outer field lipin polymer: (20 ~ 40).
Beneficial effect of the present invention: by arranging totally-enclosed double-decker, internal layer is polypropylene, and its security and stability is good, and skin is lipin polymer layer, and its insulating is good, high temperature resistant, be easy to painted, can carry out printed label to infusion bottle; The design of double-deck soft infusion bottle, makes whole infusion bottle security performance better; Be integrated hanging ring in the bottom of transfusion bottle, without the need to secondary welding link, make transfusion production minimizing one weld-ring operation; Whole transfusion bag body is flat shape, and shoulder erects, such design is convenient to that infusion process is without the need to air inlet, and medicinal liquid more at the uniform velocity can carry out venous transfusion; Four-point supporting foot is arranged at the bottom of bag, so just uprightly can stand and be convenient to dosing in the plane; The technique of this transfusion bag adopts to be extruded, the technique of blowing, this technique employing Double-mold-head extrusion die carries out Integratively and is extruded into embryonic type, technique is simple, require high without the need to complexity as noting the production of stretch blow, overcome the fault of construction of common plastics bottle and PP TYPE leakage, and make infusion bottle meets the requirement of transfusion, more can play the performance of material compared with technique before.
Accompanying drawing explanation
Fig. 1 is front view of the present invention.
Fig. 2 is side view of the present invention.
Fig. 3 is the partial cross section figure that the present invention looks up.
Wherein: 1-infuses bottle, 2-internal layer, 3-is outer, 4-hanging ring, 5-feet.
Detailed description of the invention
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, and this embodiment only for explaining the present invention, does not form limiting the scope of the present invention.
Embodiment one
As shown in Figure 1,2 and 3, the present embodiment provides a kind of double-deck medical infusion bottle and manufacture method thereof, the transfusion bottle 1 of a kind of double-deck medical infusion bottle mainly double-deck flat shape, and transfusion bottle 1 shoulder erects, and bottleneck is trapezoidal; Double-decker is the skin 3 of polyacrylic internal layer 2 and lipid copolymer, is outside equipped with the hanging ring 4 of integral type punching in the middle of the bottom of transfusion bottle 1, and the surrounding of the bottom hung ring 4 of transfusion bottle 1 arranges four feets 5; The polypropylene of internal layer 2 and the mass ratio 60:40 of the lipid copolymer of skin 3, skin can adopt high barrier material, for packing the oxidizable transfusion of aminoacid, fat milk and so on.
A manufacture method for double-deck medical infusion bottle, comprises the following steps:
Step one: by the barrel making the polypropylene material of internal layer, outer field modification lipid copolymer material is respectively charged into the extrusion die of corresponding internal layer and outer field extruding and blowing machine;
Step 2: preheating is carried out to extruding and blowing machine and blowing mould, by step one material heating and melting respectively, temperature is 220 DEG C, after melting, is extruded respectively form the tubulose embryo that internal layer is polypropylene material, skin is modification lipid copolymer material by two extrusion die heads of extruding and blowing machine;
Step 3: the tubulose embryo of bilayer step 3 formed sends into the interior shape blowing mould identical with tubulose embryo, afterwards closed blowing mould;
Step 4: remove the unnecessary tubulose embryo of blowing mould upper and lower with heating plate;
Step 5: tubulose embryo passes into compressed air and carries out bottle blowing in blowing mould, air blowing air pressure is 1.0MPa, and tubulose embryo cooling and shaping under air pressure after blowing, makes the infusion bottle of required bilayer;
Step 6: carry out punching bottom the infusion bottle of bilayer step 5 obtained, makes link.
Step 7: the infusion bottle of bilayer step 6 obtained carries out printed label.
The polypropylene of described internal layer and the mass ratio 60:40 of outer field lipin polymer.
Embodiment two
As shown in Figure 1,2 and 3, the present embodiment provides a kind of double-deck medical infusion bottle and manufacture method thereof, the transfusion bottle 1 of a kind of double-deck medical infusion bottle mainly double-deck flat shape, and transfusion bottle 1 shoulder erects, and bottleneck is trapezoidal; Double-decker is the skin 3 of polyacrylic internal layer 2 and lipid copolymer, is outside equipped with the hanging ring 4 of integral type punching in the middle of the bottom of transfusion bottle 1, and the surrounding of the bottom hung ring 4 of transfusion bottle 1 arranges four feets 5; The polypropylene of internal layer 2 and the mass ratio 70:30 of the lipid copolymer of skin 3, skin can adopt high barrier material, for packing the oxidizable transfusion of aminoacid, fat milk and so on.
A manufacture method for double-deck medical infusion bottle, comprises the following steps:
Step one: by the barrel making the polypropylene material of internal layer, outer field modification lipid copolymer material is respectively charged into the extrusion die of corresponding internal layer and outer field extruding and blowing machine;
Step 2: preheating is carried out to extruding and blowing machine and blowing mould, by step one material heating and melting respectively, temperature is 240 DEG C, after melting, is extruded respectively form the tubulose embryo that internal layer is polypropylene material, skin is modification lipid copolymer material by two extrusion die heads of extruding and blowing machine;
Step 3: the tubulose embryo of bilayer step 3 formed sends into the interior shape blowing mould identical with tubulose embryo, afterwards closed blowing mould;
Step 4: remove the unnecessary tubulose embryo of blowing mould upper and lower with heating plate;
Step 5: tubulose embryo passes into compressed air and carries out bottle blowing in blowing mould, air blowing air pressure is 1.3MPa, and tubulose embryo cooling and shaping under air pressure after blowing, makes the infusion bottle of required bilayer;
Step 6: carry out punching bottom the infusion bottle of bilayer step 5 obtained, makes link.
Step 7: the infusion bottle of bilayer step 6 obtained carries out printed label.
The polypropylene of described internal layer and the mass ratio 70:30 of outer field lipin polymer.
Embodiment three
As shown in Figure 1,2 and 3, the present embodiment provides a kind of double-deck medical infusion bottle and manufacture method thereof, the transfusion bottle 1 of a kind of double-deck medical infusion bottle mainly double-deck flat shape, and transfusion bottle 1 shoulder erects, and bottleneck is trapezoidal; Double-decker is the skin 3 of polyacrylic internal layer 2 and lipid copolymer, is outside equipped with the hanging ring 4 of integral type punching in the middle of the bottom of transfusion bottle 1, and the surrounding of the bottom hung ring 4 of transfusion bottle 1 arranges four feets 5; The polypropylene of internal layer 2 and the mass ratio 80:20 of the lipid copolymer of skin 3, skin can adopt high barrier material, for packing the oxidizable transfusion of aminoacid, fat milk and so on.
A manufacture method for double-deck medical infusion bottle, comprises the following steps:
Step one: by the barrel making the polypropylene material of internal layer, outer field modification lipid copolymer material is respectively charged into the extrusion die of corresponding internal layer and outer field extruding and blowing machine;
Step 2: preheating is carried out to extruding and blowing machine and blowing mould, by step one material heating and melting respectively, temperature is 260 DEG C, after melting, is extruded respectively form the tubulose embryo that internal layer is polypropylene material, skin is modification lipid copolymer material by two extrusion die heads of extruding and blowing machine;
Step 3: the tubulose embryo of bilayer step 3 formed sends into the interior shape blowing mould identical with tubulose embryo, afterwards closed blowing mould;
Step 4: remove the unnecessary tubulose embryo of blowing mould upper and lower with heating plate;
Step 5: tubulose embryo passes into compressed air and carries out bottle blowing in blowing mould, air blowing air pressure is 1.5MPa, and tubulose embryo cooling and shaping under air pressure after blowing, makes the infusion bottle of required bilayer;
Step 6: carry out punching bottom the infusion bottle of bilayer step 5 obtained, makes link.
Step 7: the infusion bottle of bilayer step 6 obtained carries out printed label.
The polypropylene of described internal layer and the mass ratio 80:20 of outer field lipin polymer.
Above three embodiments are by arranging totally-enclosed double-decker, and internal layer 2 is polypropylene layer, and its security and stability is good, and outer 3 is modification resin copolymer layer, good, high temperature resistant, the easy printed label of its insulating; The design of double-deck soft infusion bottle, makes whole infusion bottle security performance better; At the hanging ring 4 that the bottom of transfusion bottle is integral type, without the need to secondary welding link, make transfusion production minimizing one weld-ring operation; Whole transfusion bag body 1 is in flat shape, and shoulder erects, and such design is convenient to that infusion process is without the need to air inlet, and medicinal liquid more at the uniform velocity can carry out venous transfusion; Be convenient to printed label simultaneously.Four-point supporting foot 5 is arranged at the bottom of bag, so just uprightly can stand and be convenient to dosing in the plane; The technique of this transfusion bag adopts to be extruded, the technique of blowing, adopt Double-mold-head extrusion die to carry out Integratively and be extruded into embryonic type, technique is simple, require high without the need to complexity as noting the production of stretch blow and co-extrusion film, overcome the fault of construction of common plastics bottle and PP TYPE leakage, printing label solves the risk may mixing medicine.And make infusion bottle meets the requirement of transfusion, safer.The performance of material more can be played compared with technique before.

Claims (5)

1. a double-deck medical infusion bottle, comprises double-deck transfusion bottle (1), it is characterized in that: described transfusion bottle (1) is flat shape, and shoulder erects; Transfusion bottle (1) comprises the skin (3) of polyacrylic internal layer (2) and lipin polymer; Be outside equipped with integral type suspension ring (4) in the middle of the bottom of transfusion bottle (1), the bottom of transfusion bottle (1) arranges four feets (5).
2. a kind of double-deck medical infusion bottle as claimed in claim 1, is characterized in that: the polypropylene of described internal layer (2) and the lipin polymer copolymer quality ratio (60 ~ 80) of outer (3): (20 ~ 40).
3. a kind of double-deck medical infusion bottle as claimed in claim 1 or 2, is characterized in that: described skin (3) can also adopt high barrier material.
4. a manufacture method for double-deck medical infusion bottle as claimed in claim 1, is characterized in that: comprise the following steps:
Step one: by the barrel making the polypropylene material of internal layer, outer field lipin polymer copolymer material is respectively charged into the extrusion die of corresponding internal layer and outer field extruding and blowing machine;
Step 2: preheating is carried out to extruding and blowing machine and blowing mould, by step one material heating and melting respectively, temperature is 220 ~ 260 DEG C, after melting, is extruded respectively form the tubulose embryo that internal layer is polypropylene material, skin is lipin polymer copolymer material by two extrusion die heads of extruding and blowing machine;
Step 3: the tubulose embryo of bilayer step 3 formed sends into the interior shape blowing mould identical with tubulose embryo, afterwards closed blowing mould;
Step 4: remove the unnecessary tubulose embryo of blowing mould upper and lower with heating plate;
Step 5: tubulose embryo passes into compressed air and carries out bottle blowing in bottle blowing mould, air blowing air pressure is 1.0 ~ 1.5MPa, and tubulose embryo cooling and shaping under air pressure after blowing, makes the infusion bottle of required bilayer;
Step 6: carry out punching bottom the infusion bottle of bilayer step 5 obtained, makes link
Step 7: the skin of the infusion bottle of bilayer step 6 obtained carries out printed label.
5. the manufacture method of a kind of double-deck medical infusion bottle as claimed in claim 4, is characterized in that: the polypropylene of described internal layer and the mass ratio (60 ~ 80) of outer field lipin polymer copolymer: (20 ~ 40).
CN201410527056.2A 2014-10-09 2014-10-09 Double-layer medical infusion bottle and manufacturing method thereof Pending CN104287964A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105362069A (en) * 2015-12-08 2016-03-02 山东齐都药业有限公司 Double-layer plastic infusion bottle and production technology thereof
CN106239872A (en) * 2016-08-31 2016-12-21 安徽环球药业股份有限公司 A kind of bed die guide rod preheating Bidirectional stretch blow moulding machine
CN108891006A (en) * 2018-07-24 2018-11-27 大中塑胶电子礼品(惠州)有限公司 A kind of production technology of double-colored bottle

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1218385A (en) * 1996-04-10 1999-06-02 法玛西雅和厄普约翰公司 Improved containers for parenteral fluids
JP2000142662A (en) * 1998-10-30 2000-05-23 Hanshin Kasei Kogyo Kk Multi layer thin wall container
JP2007075368A (en) * 2005-09-14 2007-03-29 Dainippon Printing Co Ltd Outer packaging bag for infusion solution bag
CN101027178A (en) * 2003-12-10 2007-08-29 纳幕尔杜邦公司 Process for making cosmetic containers having a transparent thermoplastic outer wall
CN101559650A (en) * 2008-04-14 2009-10-21 施金亨 Multi-blank multi-layer co-extruding blow moulding machine
CN201404452Y (en) * 2008-09-12 2010-02-17 四川科伦药业股份有限公司 Plastic infusion bottle with seal cover and bottle body which are directly connected
CN101827570A (en) * 2007-10-16 2010-09-08 中央医疗服务有限公司 Double packing materials for infusion solution
CN102397160A (en) * 2010-09-07 2012-04-04 辽宁九洲龙跃药业有限公司 Polypropylene transfusion soft bag
CN103893012A (en) * 2014-03-25 2014-07-02 安徽双鹤药业有限责任公司 Three-layer medical infusion bag and manufacturing method thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1218385A (en) * 1996-04-10 1999-06-02 法玛西雅和厄普约翰公司 Improved containers for parenteral fluids
JP2000142662A (en) * 1998-10-30 2000-05-23 Hanshin Kasei Kogyo Kk Multi layer thin wall container
CN101027178A (en) * 2003-12-10 2007-08-29 纳幕尔杜邦公司 Process for making cosmetic containers having a transparent thermoplastic outer wall
JP2007075368A (en) * 2005-09-14 2007-03-29 Dainippon Printing Co Ltd Outer packaging bag for infusion solution bag
CN101827570A (en) * 2007-10-16 2010-09-08 中央医疗服务有限公司 Double packing materials for infusion solution
CN101559650A (en) * 2008-04-14 2009-10-21 施金亨 Multi-blank multi-layer co-extruding blow moulding machine
CN201404452Y (en) * 2008-09-12 2010-02-17 四川科伦药业股份有限公司 Plastic infusion bottle with seal cover and bottle body which are directly connected
CN102397160A (en) * 2010-09-07 2012-04-04 辽宁九洲龙跃药业有限公司 Polypropylene transfusion soft bag
CN103893012A (en) * 2014-03-25 2014-07-02 安徽双鹤药业有限责任公司 Three-layer medical infusion bag and manufacturing method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105362069A (en) * 2015-12-08 2016-03-02 山东齐都药业有限公司 Double-layer plastic infusion bottle and production technology thereof
CN106239872A (en) * 2016-08-31 2016-12-21 安徽环球药业股份有限公司 A kind of bed die guide rod preheating Bidirectional stretch blow moulding machine
CN106239872B (en) * 2016-08-31 2018-09-04 安徽环球药业股份有限公司 A kind of bed die guide rod of preheating Bidirectional stretch blow moulding machine
CN108891006A (en) * 2018-07-24 2018-11-27 大中塑胶电子礼品(惠州)有限公司 A kind of production technology of double-colored bottle

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Application publication date: 20150121