CN104257918B - 一种用于保肝养颜的中药制剂 - Google Patents
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Abstract
本发明提供了一种用于保肝养颜的中药制剂，是以黄芪、藿香、葛根、枳椇子、葡萄籽为原料药进行组方配伍，共奏益气扶正、升清化浊、除浊解毒、护肝养颜的作用。临床试验显示，本发明药物对于因肝脏问题而引起的脸色晦暗、暗黄以及其它症状都具有很好的调理和保养作用，总有效率达94%。另外，本发明采用药食同源的中药材为原料，具有丰富的营养价值和很好的保健功能，对人体有百利而无一害，是一种比较理想的保健食品。
Description
技术领域
本发明涉及一种用于保肝养颜的中药制剂，属于中药保健品领域。
背景技术
肝脏是人体消化系统中最大的消化腺，也是尿素合成的主要器官，又是新陈代谢的重要器官。肝脏对来自体内和体外的许多非营养性物质如各种药物、毒物以及体内某些代谢产物，具有生物转化作用；通过新陈代谢将它们彻底分解或以原形排出体外。因此，肝脏在人的代谢、消化、解毒、凝血、免疫调节等方面均起着非常重要的作用。
肝脏是人体不可或缺的一个“化工厂”。肝脏是身体重要的排毒器官，肠胃道所吸收的有毒物质，都要在肝脏经过解毒程序变为无毒物质，再经过胆汁或尿液排出体外。如果肝脏长期超负荷工作，太多的身体毒素无法及时排解出去，反映到人的皮肤上就是脸色暗哑、色素沉淀。
中医认为，肝主目主疏泄，肝气疏泄条达则气色红润，神清气爽。女人一生以血为重，肝有“造血”、“储藏”、“调节血量”和向各脏器“输送血液”的功能；还有分解营养、调节激素等功能，肝还是人体最强的解毒排毒系统和营养输送系统，滋养着女人全身的脏器。若肝不能完成这些工作，则会导致分泌失调，气血不和，从而引起各类妇科疾病，如月经失调、乳腺囊肿、子宫肌瘤、卵巢囊肿、性功能异常、不孕等。中医强调，人要经常疏肝气、清肝毒、降肝火、养肝血。疏肝气可使全身气机疏泄通畅，体内不堵则面上无痘；清肝毒可化解消除体内污染，体内无毒则脸无暗色；降肝火可使体内阴阳平衡，体内不则皮肤滋润不燥；养肝血可以滋养全身脏器，肝血充盈则体表光泽有弹性。修复受损肝脏，使全身气机疏泄条达，全身气血顺畅运行，以达到疏肝养颜目的。
发明内容
本发明的目的是提供一种用于保肝养颜的中药制剂。
本发明的中药制剂，是以黄芪、藿香、葛根、枳椇子、葡萄籽为原料药进行组方配伍，共奏益气扶正、升清化浊、除浊解毒、护肝养颜的作用。
黄芪：味甘，性温。归肺、脾经；补气固表，利尿托毒，排脓，敛疮生肌。现代药理研究表明，黄芪具有强大的全面的调节免疫作用；调节血压作用；促进血液循环作用；促进造血作用；提高细胞代谢功能作用；抗肿瘤作用；抗衰老作用；改善肾功能作用；调节血糖作用；保护脑细胞作用；增强记忆功能作用；保护肝细胞免受损伤作用。本发明以黄芪作为君药，不仅从宏观上益气扶正、解毒脱毒，而且从微观上直接修护肝脏功能。
藿香：味辛，微温；归脾、胃、肺经；芳香化浊，和中止呕，发表解暑。现代药理研究表明，藿香具有抗菌作用；杀灭并对抗螺旋体作用；除口臭作用；解暑作用。本发明以藿香作为臣药，力主中焦，升清以养荣、降浊以除毒，分解清浊，排除寒湿，以消除湿热浊气对中焦尤其肝胆脾胃的损伤。
葛根：味甘、辛，性凉；归脾、胃经；解肌退热，生津，透疹，升阳止泻。药理研究表明，葛根具有解热、消炎、抗菌、免疫作用；对心脑血管的调节作用；解痉作用；抗凝血作用；调节血压作用；抑制血小板聚集作用；抗心律失常作用；改善脑血循环作用对平滑肌的调节作用；抗癌作用；抗氧化作用；调节血糖作用；调节免疫功能的作用；解除自由基抗氧化作用。枳椇子： 味甘，性平；入心，脾、肺经；清热利尿，止咳除烦，解酒毒。药理研究表明，枳椇子具有显著的利尿作用；调节血压作用；抗脂质过氧化作用；增强耐寒和耐热功能作用。本发明以葛根与枳椇子同为佐药，直接帮助肝脏升清化浊、清热解毒，缓解肝脏本身的解毒压力，同时还能起到护肝作用。
葡萄籽：主要含多酚类成分（儿茶素、表儿茶素、没食子酸酯、油脂类成分（不饱和脂肪酸、亚油酸）、挥发性成分（醇、酚、萜类物质）、粗蛋白、氨基酸和维生素（A、E、D、K、P）、微量元素（钙、锌、铁、镁、铜、钾、钠、锰、钴等）。药理研究表明，葡萄籽具有降血脂作用；保护皮肤及美容作用；抗过敏作用；保护血管作用；抗辐射作用；保护胃肠功能作用；保护神经系统功能作用及保护眼睛作用。葡萄籽作为使药，不仅对肝脏提供有价值的营养成分，而且有助于其它四味药作用的发挥。
本发明以黄芪、藿香、葛根、枳椇子、葡萄籽为原料药进行配伍，使各药物功效产生协同，共凑益气扶正、升清化浊、除浊解毒、护肝养颜作用，进而切实维护并保护肝脏功能。
本发明药物制剂的各原料按以下重量份进行配比：黄芪25-40份、藿香15-25份、葛根7-15份、枳椇子7-15份、葡萄籽5-10份。
优选配比：黄芪30-40份、藿香16-20份、葛根10-14份、枳椇子10-14份、葡萄籽7-9份。
最佳配比：黄芪32份、藿香16份、葛根12份、枳椇子12份、葡萄籽8份。
本发明的药物制剂可按中药药剂学的常规工艺和辅料制备成各种内服制剂。如胶囊剂、片剂、颗粒剂、散剂、丸剂（包括水丸、蜜丸、糖衣丸、胶丸、肠溶丸或滴丸）或口服液。
下面是本发明中药制剂用于保肝养颜的临床资料。
1、临床观察对象：女性100例。观察对象通过现代仪器和化验全面体检均无阳性指标，无明显的器质性病变者。但经中医确诊为肝脏不好，并有以下症状者：全身倦怠；食欲不振，有恶心感觉；脸色晦暗、失去光泽；皮肤呈暗黄色；头晕或头昏。
2、治疗方法：本发明胶囊剂剂药（掰拜胶囊），规格：350mg/粒，80粒/瓶。早晚各3粒，3个月1周期。经期不停用。
3、判断标准：上述各种症状完全消除者为痊愈；消除60%以上者为显效；消除30%以上者为有效；其它为无效。
4、测定结果：临床治愈46例，显效22例，有效26例，无效6例。总有效率：94 %。
上述临床试验显示，本发明药物对于因肝脏问题而引起的脸色晦暗、暗黄以及其它症状都具有很好的调理和保养作用。另外，本发明采用药食同源的中药材为原料，具有丰富的营养价值和很好的保健功能，对人体有百利而无一害，是一种比较理想的保健食品。
具体实施方式
下面通过具体实施例对本发明药物的组分及其制备作进一步说明。
实施例1、颗粒剂药物的制备
原料配方：黄芪32份、藿香16份、葛根12份、枳椇子12份、葡萄籽8份；
制备工艺：按药剂学制备颗粒剂的常规工艺和辅料制备而成。每袋5g；
使用方法：一日2次，一次服5g，连续服用3个月为一疗程。
实施例2、片剂药物的制备
原料配方：黄芪25份、藿香15份、葛根7份、枳椇子7份、葡萄籽5份；
制备工艺：按药剂学制备片剂的常规工艺和辅料制备而成。每粒1.0g；
使用方法：一日2次，一次服2粒，连续服用90天为一疗程。
实施例3、胶囊剂药物的制备
原料配方：黄芪40份、藿香25份、葛根15份、枳椇子15份、葡萄籽10份；
制备工艺：按药剂学制备胶囊剂的常规工艺和辅料制备而成。350mg/粒；
使用方法：一日2次，一次服3粒，连续服用90天为一疗程。
实施例4、滴丸剂药物的制备
原料配方：黄芪30份、藿香16份、葛根10份、枳椇子10份、葡萄籽7份；
制备工艺：按药剂学制备滴丸剂的常规工艺和辅料制备而成。每粒0.05g；
使用方法：一日2次，一次服18粒，连续服用90天为一疗程。
实施例5、口服液的制备
原料配方：黄芪40份、藿香20份、葛根14份、枳椇子14份、葡萄籽19份；
制备工艺：按药剂学制备口服液的常规工艺和辅料制备而成。每瓶10ml；
使用方法：一日2次，一次服20ml，连续服用30天为一疗程。
上述各实施例中，药物配比均以重量份计。
Claims (4)
1.一种用于保肝养颜的中药制剂，是以黄芪、藿香、葛根、枳椇子、葡萄籽为原料，按药剂学的常规工艺和辅料制备成的内服制剂；所述各原料按以下重量份进行配比：黄芪25-40份、藿香15-25份、葛根7-15份、枳椇子7-15份、葡萄籽5-10份。
2.如权利要求1所述用于保肝养颜的中药制剂，其特征在于：所述各原料按以下重量份进行配比：黄芪30-40份、藿香16-20份、葛根10-14份、枳椇子10-14份、葡萄籽7-9份。
3.如权利要求1所述用于保肝养颜的中药制剂，其特征在于：所述各原料按以下重量份进行配比：黄芪32份、藿香16份、葛根12份、枳椇子12份、葡萄籽8份。
4.如权利要求1所述用于保肝养颜的中药制剂，其特征在于：所述内服制剂为片剂、胶囊剂、丸剂、颗粒剂、口服液。
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