CN104225738A - Airflow guiding type orientation in-situ flash melting electrostatic spraying device and application thereof - Google Patents
Airflow guiding type orientation in-situ flash melting electrostatic spraying device and application thereof Download PDFInfo
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- CN104225738A CN104225738A CN201410520619.5A CN201410520619A CN104225738A CN 104225738 A CN104225738 A CN 104225738A CN 201410520619 A CN201410520619 A CN 201410520619A CN 104225738 A CN104225738 A CN 104225738A
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- Nozzles (AREA)
- Electrostatic Spraying Apparatus (AREA)
Abstract
An airflow guiding type orientation in-situ flash melting electrostatic spraying device comprises a control box, a liquid container, a temperature control system, a pressurization system, an electric stirring system, a liquid inlet pipe, a spray gun handle, a spray head, an airflow guiding pipe and a high-voltage wire, wherein the spray head is arranged at the front end of the spray gun handle, a metal needle connected with the liquid inlet pipe is arranged in the spray head, the high-voltage wire is connected to the pipe wall of the metal needle, an air channel formed between the outer wall of the metal needle and the inner wall of the spray head is communicated with the airflow guiding pipe through the spray gun handle, materials to be sprayed and solvent are added into the liquid container and form a constant-temperature solution under the action of the electric stirring system and the temperature control system, the solution is squeezed into the liquid inlet pipe through the pressurization system and enters the metal needle through the liquid inlet pipe, the voltage and current are controlled through the control box, and then airflow guiding type orientation in-situ electrostatic spraying is achieved. The device can be widely applied to the fields of medical hemostasis, war wound help, tissue engineering, cosmetics and industrial spraying.
Description
Technical field
The present invention relates to medical device technical field, particularly a kind ofly utilize electrostatic spinning technique to guide in conjunction with air-flow to realize medicinal liquid and biomaterial for medical purpose directly at the directed original position electrostatic spraying apparatus of air-flow guiding that target place fixed point, directed, original position accurately spray.
Background technology
Electrostatic spraying a kind ofly makes the directed movement under the effect of high-pressure electrostatic electric field force of the solution to be sprayed of a large amount of electrostatic charge of band, forms electrified jet, thus realize the method that solution applies at target object surface.Electrostatic spraying mainly contains electrostatic spray and electrostatic spinning two kinds of forms.Wherein, electrostatic spray is mainly used in the atomization without ropiness liquid such as water or aqueous solution or paint etc., be mainly used in crops spray pesticide and automobile, household electrical appliances, instrument shell spray paint; Electrostatic spinning is the specific form of polymeric fluid electrostatic atomization, volatile organic solvent is utilized to prepare the solution with certain viscosity, electrostatic field is produced by HV generator, making solution divide in nozzle atomization the material is not fine droplet, but the small jet of polymer, jet through splitting, stretching, solvent volatilization process, is finally solidified into fiber in atmosphere, is deposited on target collection and extremely goes up.
In electrostatic spray process, because the diversity of electric field line distributes, and with the repulsive interaction of a large amount of electrostatic charge atomized drop of the same race or electrospinning fibre, can make atomized drop or fiber on target object, produce very large spraying area, even can be coated to the back side of target object, namely produce ring bag effect.When Electrostatic Spray Technology is used for medical field, ring bag effect can cause applying inaccuracy, medicinal liquid is coated to unwanted region, not only cause the waste of medicine, and when wound surface is positioned at body cavity deep, charged medicine major part can be adsorbed to from spout more close to organ surface on, produce faraday cup effect, effectively cannot apply wound surface.Ring bag effect and faraday cup effect hinder the development of Electrostatic Spray Technology at medical field.
Along with development and the needs of biological dressing, dressing materials and structure must be suitable for the needs that tissue is repaired.Usual bio-medical dressing can be divided into dressing in external dressing and body.Wherein, external dressing mainly comprises burn and scald dressing, hemostasis and anti-inflammation dressing, binder etc.In body, dressing mainly refers to isolating membrane of performing the operation, and is particularly applied to the operation of cardiovascular organ anti isolation.Simple as one, the efficient nanofiber membrane preparation method of electrostatic spinning, is extensively studied development and application.In medical haemostatic; Electrospun nano-fibers film not only has permeability but also can provide effective barrier protection structure; its pore-size distribution can control to enough little of the invasion stopping antibacterial; and evenly can stick in moistening wound surface and prevent dehydration, thus be suitable as very much dressing for skin and artificial skin.In addition, electrospun fiber membrane also has the specific surface area of superelevation, can carry the multiple beneficial composition comprising antibacterials in a large number, is conducive to the healing and the tissue regeneration that promote damaged part.In beauty industry, electrospinning fibre also can be made into facial film, adds in fiber by electrospinning by beneficiating ingredient, and fibrous membrane not only has excellent absorption, cleaning action, beneficial agents stable and uniform human body be can be passed to contact skin simultaneously, absorption and the transport of tissue are beneficial to.
Patent CN 201320741232.3 devises the directed original position electrostatic spraying apparatus of a kind of air-flow guiding, a-cyanoacrylate medical adhesive electrospinning can be become micro nanometer fiber, and accurate uniform deposition forms dense film to wound surface under air-flow guiding, thus in several seconds to tens seconds, realize hemostasis rapidly, allow operation become safer sooner.
Summary of the invention
The object of the invention is to, a kind of air-flow guiding directed original position thermosol electrostatic spraying apparatus is provided, the medical solvent such as water, ethanol or acetone are utilized to carry out thermosol to sprayed on material and complete electrostatic spraying, overcome the shortcoming that existing Electrostatic Spray Technology is applied at medical field, realize soluble agents and biomaterial for medical purpose and directly accurately spray in human body wound surface target place fixed point, directed, original position.
Technical scheme of the present invention is:
A kind of air-flow guiding directed original position thermosol electrostatic spraying apparatus, comprise control chamber, liquid reservoir, temperature control system, compression system, electric stirring system, feed tube, gun handle, shower nozzle, airflow duct and high-voltage conducting wires, high voltage power supply and air pump is provided with in described control chamber, wherein: described shower nozzle is arranged on gun handle front end, in shower nozzle, be provided with metal needle; This metal needle is connected with liquid reservoir by feed tube; The tube wall of this metal needle is then connected by the positive pole of high-voltage conducting wires with the high voltage power supply in control chamber; In shower nozzle, the space formed between the outer wall of metal needle and the inwall of shower nozzle is gas channel, and this gas channel is connected with airflow duct by gun handle, and airflow duct is connected with air pump; Material to be sprayed and solvent join in liquid reservoir, under the stirring of electric stirring system and under the control of temperature control system, material to be sprayed fully dissolves and holding temperature constant homogeneous in liquid reservoir, then by compression system, solution in liquid reservoir is clamp-oned feed tube, metal needle is entered by feed tube, control the voltage of high voltage power supply and the air-flow size of air pump by control chamber, realize the directed original position electrostatic spraying that air-flow guides.
Further, above-mentioned shower nozzle can be provided with integrated sensor-based system, comprise Distance-sensing system, temperature and humidity sensing system and high speed imaging system, possesses the function independently measuring shower nozzle and handling objects distance, surrounding temperature-humidity monitoring, electrostatic spray process high speed imaging respectively, its separately mutual when working do not disturb, unified collect process data by computer.Here computer can monitor duty and the dynamic parameter of electrostatic spraying in real time as aid system, to data collection during spraying and process and in time adjust more favourable technological parameter and have important help.
Further, described temperature control system can comprise temperature sensor and the heating coil coil around resistance to liquid reservoir.Described heating coil coil two ends, by wire connection control case, regulated and controled, and the Current Temperatures of solution in liquid reservoir are monitored in temperature sensor in real time by the temperature adjustment knob on control chamber, realize temperature constant function by feedback and automatic adjustment.
Further, described electric stirring system can be made up of small rotary motor and the stirring-head be attached thereto, and wherein stirring-head is positioned at liquid reservoir, immerses in heating and thermal insulation solution to be sprayed, keeps solution in liquid reservoir to be heated evenly by stirring.
Further, described compression system utilizes pneumatic diaphragm pump, and employing Compressed Gas is power source, provides enough ambient pressures thus solution is extruded from the nozzle of liquid reservoir to liquid reservoir, and spraying rate can carry out active adjustment by the external pressure size provided.Selected Compressed Gas can be nitrogen, argon, carbon dioxide, air etc.
Described control chamber is provided with for grafting airflow duct socket, be used for socket, the temperature adjustment knob that is used for regulating the voltage-regulation knob of high-voltage power voltage size, is used for regulating the gas flow modulation knob of air pump air-flow size, is used for regulating temperature control system temperature height of high-voltage conducting wires of socket connection high-voltage power cathode and shower nozzle.The minus earth of the high voltage power supply in described control chamber.
Above-mentioned thermosol electrostatic spraying apparatus, can comprise a thermal insulation casing further, and described feed tube is sleeved in this thermal insulation casing.
Preferably, described feed tube is polyfluortetraethylene pipe; Described airflow duct is silica gel airflow duct; Described thermal insulation casing is incubated internal layer by polrvinyl chloride skin and asbestos and forms.
Above-mentioned thermosol electrostatic spraying apparatus is applicable to need to dissolve by medical solvent such as water, ethanol or acetone, and then implements the material of electrostatic spraying.In a preferred embodiment of the invention, selectable sprayed on material comprises natural macromolecular material, as gelatin, hyaluronic acid, sodium alginate, chitosan, cellulose ethanoate, fibroin albumen, collagen protein etc.; And other functional materials, as Polyethylene Glycol, polyvinyl alcohol, poly hydroxy ethyl acrylate and water soluble polypeptide (as polylysine, poly-aspartate etc.), and the mixture of two or more above-mentioned materials.
Apparatus of the present invention be used for spray shower nozzle and metal needle between form gas channel, be connected with air pump by airflow duct, air-flow can guide medicinal liquid to be sprayed to move along airflow direction, play orientating function, can also play constraint effect by weakening ring bag effect and faraday cup effect, thus realization fixed point orientation accurately sprays.Thermosol electrostatic spraying apparatus of the present invention compensate for the deficiency of existing spraying technology, such as successful electrospinning multiple under conventional environment cannot or the biomaterial of extremely difficult electrospinning, and use the medical solvent such as water, ethanol or acetone to reduce the risk of environmental pollution, the extensive use made it in each field particularly medical domain becomes a reality.Biomaterial prepared by this device is applicable to multiple use: medical haemostatic aspect, as clinical operation hemostasis, burn and scald dressing, hemostasis and anti-inflammation sterilized dressing, medical bandage, operation suture thread, vascular organs's anti operation isolating membrane; Organizational project aspect, as made organization bracket, tissue filler, artificial skin, wound dressing for skin regeneration, and carries out medicine and to load and oriented control discharges; Cosmetic field, as the making of facial film and the nursing of skin.Especially, the present invention has started the new way of the potential basic research adhering to hemostatic material, can solve operation safety and postoperative rehabilitation controls wound surface bleeding problems; The theory of innovation and the real-time combination of surgical hemostasis technology, carry out application and the treatment of reliable hemostatic technique.Utilize device of the present invention can change the application mode of current conventional medical material simultaneously, fully can ensure adhesion, the safety of biomedical material, realize the reconstruction of parenchymal viscera continued integrity.
Accompanying drawing explanation
Fig. 1 is the structural representation of the air-flow guiding directed original position thermosol electrostatic spraying apparatus of embodiment 1.
Fig. 2 is two kinds of electrostatic spraying view of air-flow guiding of the present invention directed original position thermosol electrostatic spraying apparatus.
Fig. 3 is the directed in-situ deposition principle schematic of air-flow guiding of the present invention directed original position thermosol electrostatic spraying apparatus.
Fig. 4 is different electrospinning fibre optical photographs prepared by embodiment 1, and wherein (a) is gelatin/Polyethylene Glycol electrospinning fibre, and (b) is sodium alginate/polyvinyl alcohol electrospinning fibre.
Wherein: 1: control chamber; 2: on and off switch; 3: voltage-regulation knob; 4: gas flow modulation knob; 5: temperature adjustment knob 6: thermal insulation casing; 7: metal needle; 8: feed tube; 9: gun handle; 10: rotary type shower nozzle; 11: integrated sensor-based system; 12: air-flow guides lower tow; 14: high-voltage conducting wires; 15: airflow line; 16: temperature sensor; 17: electric stirring system; 18: compression system; 19: chamber is filled in; 20: heating coil coil; 21: bracing frame; 22: high temperature resistant liquid reservoir; 23: nozzle; 24: heater coil wire.
Detailed description of the invention
Below in conjunction with accompanying drawing, by embodiment, the present invention is described in further detail.
Embodiment 1
As shown in Figure 1, the thermosol electrostatic spraying apparatus of the present embodiment comprises control chamber 1, thermal insulation casing 6, feed tube 8, gun handle 9, rotary type shower nozzle 10, integrated sensor-based system 11, high-voltage conducting wires 14, airflow duct 15, high temperature resistant liquid reservoir 22 and temperature control system thereof, compression system 18, electric stirring system 17.Described control chamber 1 is built with the air pump regulated and controled by gas flow modulation knob 4 and the high voltage power supply regulated and controled by voltage-regulation knob 3.Rotary type shower nozzle 10 is arranged on gun handle 9 front end; Feed tube 8 is sleeved in thermal insulation casing 6, and is connected with the metal needle 7 be arranged in shower nozzle 10 through gun handle 9; Airflow duct 15 one end connects air pump, and the other end is connected on the end of gun handle 9.Be arranged in shower nozzle 10, and the tube chamber of the metal needle 7 be connected with feed tube 8 is connected with high-voltage conducting wires 14, high-voltage conducting wires 14 other end is connected with the high-voltage power cathode in control chamber 1.The circulating line space formed between described shower nozzle 10 inwall and metal needle 7 outer wall is gas channel, air pump in control chamber 1 is produced the air-flow with certain pressure and is connected with this gas channel by airflow duct 15, and the air-flow in air pump can be sprayed from the gas channel in shower nozzle 10.
Liquid reservoir 22 is fixed on bracing frame 21, and described temperature control system comprises the temperature adjustment knob 5 on temperature sensor 16, heating coil coil 20, heater coil wire 24 and control chamber 1.Described heating coil coil 20 is centered around around high temperature resistant liquid reservoir 22, heating coil coil 20 two ends are connected with control chamber 1 by heater coil wire 24, heating-up temperature needed for temperature adjustment knob 5 scalable, temperature sensor 16 can monitor Current Temperatures in real time, realizes temperature constant function by feedback and automatic adjustment.Described electric stirring system 17 comprises small rotary motor and stirs turbine, and stirring-head immerses in high temperature solution to be sprayed, keeps solution to be heated evenly by stirring.Compression system 18 utilizes pneumatic diaphragm pump, and adopt Compressed Gas to provide enough pressure to liquid reservoir 22 for power source, thus solution is extruded from nozzle 23, spraying rate can be regulated by the air pressure size provided.Selected Compressed Gas can be nitrogen, argon, air, carbon dioxide etc.
The integrated sensor-based system 11 that shower nozzle 10 is arranged comprises Distance-sensing system, temperature and humidity sensing system and high speed imaging system, possesses the function independently measuring shower nozzle 10 and handling objects distance, surrounding temperature-humidity monitoring, electrostatic spray process high speed imaging respectively, its separately mutual when working do not disturb, unified collect process data by computer.
Described control chamber 1 is provided with on and off switch 2, voltage-regulation knob 3, gas flow modulation knob 4, temperature adjustment knob 5 and is positioned at the display screen of display parameters above these knobs.During spraying, first joined in liquid reservoir 22 by solution to be sprayed, turn on the power switch 2, temperature control system and electric stirring system 17 are started working.Successively regulate temperature adjustment knob 5 (controllable temperature scope is about 50-400 degree Celsius), gas flow modulation knob 4 (flow is about 5-20 liter/min), voltage-regulation knob 3 (controllable voltage is up to 30 kilovolts), can be adjusted to different parameters as required respectively; After temperature stabilization, open compression system 18, pistol handle 9, the object that aimed at the mark by shower nozzle 10 starts spraying.According to the difference of SOLUTION PROPERTIES, this device has original position electrostatic spinning spraying (Fig. 2 is left) and electrostatic spray spraying (Fig. 2 is right) two kinds of functions.After spraying terminates, successively regulate compression system 18, temperature adjustment knob 5, voltage-regulation knob 3, gas flow modulation knob 4 to minimum, last powered-down switch 2.
Thermosol electrostatic spraying apparatus of the present invention, under air-flow is auxiliary, can realize the accurate control of range of deposition and deposition station.Its directed in-situ deposition principle as shown in Figure 3, using the water surface in culture dish as collection substrate, after opening air pump, air-flow blows to the water surface by shower nozzle, water to flow towards periphery formation one small holes under air-flow extruding, show that auxiliary not only can the help of air-flow realizes accurately spraying and orientated deposition, can also the surface of effective clean catch substrate.
Illustrate that the process of thermosol electrostatic spinning is as follows for the thermosol electrostatic spinning of gelatin/Polyethylene Glycol:
First take 4g gelatin and 0.5g Polyethylene Glycol mixes with 10g deionized water, first at room temperature leave standstill 30 minutes, then in 60 DEG C of water-baths, heated and stirred 2 is little of transparent and homogeneous state, obtains precursor solution.Get appropriate precursor solution to be injected in liquid reservoir 22, turn on the power switch 2, temperature control system and electric stirring system 17 are started working.Successively regulate temperature adjustment knob 5 (temperature is set as 60 DEG C), gas flow modulation knob 4 (flow is 10 liters/min), voltage-regulation knob 3 (voltage sets is 20 kilovolts); After temperature stabilization, open compression system 18, pistol handle 9, the object that aimed at the mark by shower nozzle 10 starts spraying, and form air-flow and guide lower tow 12, spray time 1 minute, gelatin/Polyethylene Glycol fiber deposits film forming gradually.After spraying terminates, successively regulate compression system 18, temperature adjustment knob 5, voltage-regulation knob 3, gas flow modulation knob 4 to minimum, last powered-down switch 2.
Be illustrated in figure 4 (a) gelatin/Polyethylene Glycol electrospinning fibre and (b) sodium alginate/polyvinyl alcohol electrospinning fibre optical photograph that utilize thermosol electrostatic spraying apparatus to prepare.
Claims (10)
1. the directed original position electrostatic spraying apparatus of air-flow guiding, comprise control chamber, liquid reservoir, temperature control system, compression system, electric stirring system, feed tube, gun handle, shower nozzle, airflow duct and high-voltage conducting wires, high voltage power supply and air pump is provided with in described control chamber, wherein: described shower nozzle is arranged on gun handle front end, in shower nozzle, be provided with metal needle; This metal needle is connected with liquid reservoir by feed tube; The tube wall of this metal needle is then connected by the positive pole of high-voltage conducting wires with the high voltage power supply in control chamber; In shower nozzle, the space formed between the outer wall of metal needle and the inwall of shower nozzle is gas channel, and this gas channel is connected with airflow duct by gun handle, and airflow duct is connected with air pump; Material to be sprayed and solvent join in liquid reservoir, under the stirring of electric stirring system and under the control of temperature control system, material to be sprayed fully dissolves and holding temperature constant homogeneous in liquid reservoir, then by compression system, solution in liquid reservoir is clamp-oned feed tube, metal needle is entered by feed tube, control the voltage of high voltage power supply and the air-flow size of air pump by control chamber, realize the directed original position electrostatic spraying that air-flow guides.
2. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 1, it is characterized in that, described shower nozzle is provided with integrated sensor-based system, this integrated sensor-based system comprises: for measuring the Distance-sensing system of shower nozzle and handling objects distance, for the temperature and humidity sensing system of surrounding being monitored humiture, with, for the high speed imaging system to electrostatic spray process high speed imaging.
3. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 1, is characterized in that, described temperature control system comprises the temperature sensor around solution temperature in the heating coil coil and real-time monitoring liquid reservoir of liquid reservoir; Described heating coil coil two ends are by wire connection control case.
4. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 1, it is characterized in that, described compression system utilizes pneumatic diaphragm pump, adopts Compressed Gas to provide enough pressure to liquid reservoir for power source, thus the solution in liquid reservoir is extruded from liquid reservoir nozzle.
5. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 1, it is characterized in that, described electric stirring system is made up of small rotary motor and the stirring turbine be attached thereto, and wherein stirs turbine and is positioned at liquid reservoir.
6. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 1, is characterized in that, the directed original position electrostatic spraying apparatus of described air-flow guiding also comprises a thermal insulation casing, and described feed tube is sleeved in this thermal insulation casing.
7. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 6, is characterized in that, described thermal insulation casing is incubated internal layer by polrvinyl chloride skin and asbestos and forms.
8. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 1, it is characterized in that, described feed tube is polyfluortetraethylene pipe; Described airflow duct is silica gel airflow duct.
9. the directed original position electrostatic spraying apparatus of air-flow guiding according to claim 1, it is characterized in that, described control chamber is provided with for grafting airflow duct socket, be used for the socket of grafting high-voltage conducting wires, the adjusting knob that is used for regulating the adjusting knob of high-voltage power voltage size, is used for regulating the adjusting knob of air pump air-flow size and is used for regulating temperature control system temperature height.
10. the directed original position electrostatic spraying apparatus of the arbitrary described air-flow guiding of claim 1 ~ 9 is in the application in organizational project and cosmetics field.
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