CN104203305B - Treatment solution conveying in extracorporeal blood treatment equipment - Google Patents

Abstract

This document describes haemodialysis equipment and using method thereof, this haemodialysis equipment includes two or more intermediate receptacles between treatment source of solvent and the port utilizing haemodialysis equipment conveying treatment solution.The weight of these intermediate receptacles is measured and for controlling treatment the refilling and emptying of solution in intermediate receptacle.

Description

Treatment solution conveying in extracorporeal blood treatment equipment

Technical field

This document describes equipment and the method for conveying treatment solution in haemodialysis equipment and correlation technique in vitro.

Background technology

Extracorporeal blood treatment means to obtain blood from patient, at patient's external treatment blood, and is returned by the blood after treatment Back to patient.Extracorporeal blood treatment is generally used for extracting undesirable substance or molecule from the blood of patient and/or adding to blood Add benefit materials or molecule.Extracorporeal blood treatment for cannot effectively from its blood eliminating material patient (such as, exist In the case of suffering from the patient of temporarily or permanently renal failure).These and other patients can stand extracorporeal blood treatment with to Its blood substance or from its blood get rid of material, such as to maintain acid-base balance or to eliminate too much body fluid.

Extracorporeal blood treatment the most so performs: gathers the blood of patient with continuous stream, is introduced to partially by blood The main chamber of the filter limited by semipermeable membrane.According to the type for the treatment of, semipermeable membrane optionally makes to be included in blood In harmful substance can arrive secondary chamber from main chamber through film, and optionally make to be included in entrance secondary chamber Benefit materials in liquid can arrive into the blood of main chamber through film.

Multiple extracorporeal blood treatment can be performed by uniform machinery.In ultrafiltration (UF) is treated, by secondary chamber is worn The convection current crossing film to get rid of harmful substance from blood.

In hemofiltration (HF) is treated, as in UF, blood flows through the room limited at least in part by semipermeable membrane, Benefit materials is added blood to (generally by being returned to before or after passing filter at blood and at blood Introduce fluid in blood before patient).

In hemodialysis (HD) is treated, a secondary fluid comprising benefit materials is introduced in the secondary chamber of filter. The harmful substance of blood is by diffusing through semipermeable membrane and penetrating in a secondary fluid, and the benefit materials of a secondary fluid can be worn Cross film and penetrate in blood.

In hemodiafiltration (HDF) is treated, blood exchanges their material with a secondary fluid as in HD, It addition, material is added blood to (generally by being drawn by fluid before being returned to patient at blood as in HF Enter the blood for the treatment of)；Harmful substance is got rid of from blood by convection current and diffusion.

In those treatments using a secondary fluid, a secondary fluid is through the secondary chamber of filter and by the diffusion through film And/or the harmful substance of stream reception blood.Then this liquid is extracted from filter: this liquid is commonly called waste liquid, And it is sent to drainage tube (drain) or container (being then intended to be discharged to drainage tube).

In the external treatment using a secondary fluid, as it is shown in figure 1, a secondary fluid can be supplied in aseptic disposable bags. To this end, a secondary fluid can be included in the dialysis solution in dialyzate bag 11.Dialyzate bag 11 is by export pipeline 9 Dialysis solution is delivered to secondary chamber 4.This bag 11 and the weight meter (gravimetric scale) being linked to control unit 41 21 combinations.Therefore, weight signal is sent to control unit 41, and this control unit 41 can monitor the weight of bag 11 Amount changes and control action is in the pump 31 of export pipeline 9 (that is, carrying the pipeline of dialysis solution from bag 11 to secondary chamber 4).

But, in some embodiments, many days can be continued the course for the treatment of, disposable dialyzate bag 11 terminates it in the course for the treatment of Before will exhaust.This phenomenon can be more notable during intensive treatment.Certainly, people had both wished at HF or HDF Therapy exchanges big quantity of fluid, it is also desirable to perform long-term treatment.

Bag 11 1 reach setting level (or user select another time), act on export pipeline 9 pump (or Other pump as required) can stop temporarily, and blood continues extracorporeal circulation in the main chamber 3 of filter.Once pump 31 stop, and user have to be off and take off the dialyzate bag 11 of sky.Then user is by attached for new full disposable bags 11 Connect and be connected to therapeutic equipment, and restart pump to return to utilize stream by two rooms (3,4) of filter 2 The external treatment of body circulation.

This bag replacement operation has multiple potential defect.This operation is held by the medical personnel that must monitor multiple patient simultaneously (waiting time before personnel's action generally increases treatment time and may need the additional treatment time or cause row Therapeutic efficiency reduces), the periodic replacement of dialyzate bag adds the Financial cost for the treatment of during the course for the treatment of, and bag is heavy Weight and the bad object of relative flimsiness and be difficult to show off, may be pierced potentially when showing off.

Although being delivered into line description herein in connection with dialysis solution, it should be appreciated that, infusing in blood (no matter Before the filter or afterwards or before blood pump) haemodialysis equipment in be likely to run into Similar Problems.For Discussion herein, these fluids any will be referred to as " treatment solution ", and it can include (such as) dialysis solution；Renal function Convection current auxotherpy in displacement liquid；Spendable blood plasma, albumin or glue in therapeutic plasma exchange (TPE) Liquid solution；Or the medical fluid of other known type any for auxotherpy.

Summary of the invention

Haemodialysis equipment as herein described includes being positioned at treatment source of solvent with to utilize the conveying treatment of haemodialysis equipment molten Two or more intermediate receptacles between the port of liquid.The weight of these intermediate receptacles is measured and is used for controlling centre Treatment the refilling and emptying of solution in container.Remaining at treatment source of solvent and haemodialysis equipment as described herein Position between part use two or more intermediate receptacles can reduce or eliminate intermediate receptacle emptying and/or again Conveying treatment solution is stopped changing the needs of intermediate receptacle during filling.As a result, unbroken treatment persistent period can show Write and increase.

It is typically based on the weight (being determined by weight meter as herein described) of the treatment solution being delivered to o controller Control to be delivered to the amount of the treatment solution of the selected part of haemodialysis equipment.In some embodiments, it is possible to extremely The weight change being at least partly based on intermediate receptacle controls the flow velocity of the treatment solution by o controller.

In one aspect, some embodiments of haemodialysis equipment as herein described include: blood circuit, and it includes It is intended to extract the arterial line of blood from patient and be intended to return to blood the venous line of described patient；And control Treating solution delivery system, it is configured in described haemodialysis equipment by treatment solution port conveying treatment molten Liquid.Described treatment solution delivery system comprises the steps that the first weight meter, and it is configured to weigh the first intermediate receptacle； Second weight meter, it is configured to weigh the second intermediate receptacle；Source flux controller, it is configured to from treatment molten Liquid source is to described first intermediate receptacle weighed by described first weight meter and the institute weighed by described second weight meter State the second intermediate receptacle conveying treatment solution；O controller, its be configured to control from described first intermediate receptacle and Described second intermediate receptacle is to the flowing of the treatment solution of described treatment solution port；Container selection control, it is positioned at In treatment solution path between described source flux controller and described o controller；Control unit, it is operationally It is attached to described first weight meter, described second weight meter, described source flux controller, described container selection control With described o controller.Described control unit is configured to: receive weight from described first weight meter and the second weight meter Amount signal；Control described source flux controller, described container selection control and described output in the flrst mode to control Device, wherein treatment solution is fed to described o controller, and treats solution and leave described first intermediate receptacle, and And described second intermediate receptacle treatment solution fill；Control described source flux controller, described appearance under the second mode Device selection control and described o controller, wherein said second intermediate receptacle is to the conveying treatment of described o controller Solution, and described first intermediate receptacle utilizes the treatment solution from described treatment source of solvent to fill.

In some embodiments of haemodialysis equipment as herein described, it is described that described control unit is configured to control Source flux controller, described container selection control and described o controller so that when in described first mode and institute The continuous stream for the treatment of solution is provided to described treatment solution port when stating switching between the second pattern.

In some embodiments of haemodialysis equipment as herein described, described haemodialysis equipment includes filter, This filter has the main chamber and secondary chamber separated by semipermeable membrane, and wherein, described blood circuit is configured to make blood warp Cross described main chamber, and wherein, described treatment solution port is configured to described secondary chamber conveying treatment solution.

In some embodiments of haemodialysis equipment as herein described, described treatment solution port is configured to institute State the blood conveying treatment solution in blood circuit.

In some embodiments of haemodialysis equipment as herein described, described equipment includes air monitor, this sky Gas detector is between described treatment source of solvent and described first intermediate receptacle and the second intermediate receptacle so that from described Treatment source of solvent is delivered to examine through described air with the treatment solution of described first intermediate receptacle and the second intermediate receptacle Survey device.

In some embodiments of haemodialysis equipment as herein described, described equipment includes sterilising filter, and this goes out Bacterium filter is between described treatment source of solvent and described treatment solution port so that be delivered to institute from treatment source of solvent State the treatment solution for the treatment of solution port through described sterilising filter.In some embodiments, described sterilising filtration Device is between described treatment source of solvent and described first intermediate receptacle and the second intermediate receptacle so that from treatment source of solvent It is delivered to the treatment solution of described first intermediate receptacle and the second intermediate receptacle through described sterilising filter.

In some embodiments of haemodialysis equipment as herein described, described equipment includes source flux controller, should Source flux controller is between described treatment source of solvent and described first intermediate receptacle and the second intermediate receptacle so that from Described treatment source of solvent is delivered to the treatment solution of described first intermediate receptacle and described second intermediate receptacle through described Source flux controller.Sterilising filter can be located at source flux controller and the first intermediate receptacle and the second intermediate receptacle it Between so that it is delivered to the treatment solution of the first intermediate receptacle and the second intermediate receptacle through described sterilizing from treatment source of solvent Filter.Sterilising filter (if including) can have the passive pore including hydrophobic membrane.

In some embodiments of haemodialysis equipment as herein described, described treatment source of solvent includes multiple supply storage Storage.

In some embodiments of haemodialysis equipment as herein described, described treatment source of solvent includes fluid supply, controls Treating solution precursors and mixing apparatus, this mixing apparatus is configured to from the liquid of fluid supply and treatment solution precursors group Close to form treatment solution.

In some embodiments of haemodialysis equipment as herein described, described container selection control includes valve, should Valve is configured with open mode and closed mode, in the on-state, it is allowed to flow through the pipe that described valve is acted on Road, in off position under, stop flow through the pipeline that described valve is acted on.

In some embodiments of haemodialysis equipment as herein described, described container selection control includes pump, institute State pump to be configured as during described pump work treating solution by the Pipeline transport at described pump place, when described air pump inoperative Time stop treatment solution to flow through the described pipeline at described pump place.

In some embodiments of haemodialysis equipment as herein described, described container selection control includes multichannel Valve, wherein, in configuring first, the permission of described banked direction control valves flows to described from the treatment solution of described treatment source of solvent In first intermediate receptacle and stop described treatment solution to flow in described second intermediate receptacle, and wherein, join second In putting, described banked direction control valves allows the treatment solution from described treatment source of solvent flow in described second intermediate receptacle and hinder Only described treatment solution flows in described first intermediate receptacle.

In some embodiments of haemodialysis equipment as herein described, the first intermediate receptacle rate of discharge controller and Second intermediate receptacle rate of discharge controller includes banked direction control valves, and wherein, in configuring first, described banked direction control valves allows Flow to described o controller from the treatment solution of described first intermediate receptacle and stop from described second intermediate receptacle Treatment solution flow to described o controller, and wherein, in configuring second, described banked direction control valves allows from institute The treatment solution stating the second intermediate receptacle flows to described o controller and stops controlling from described first intermediate receptacle Treat solution and flow to described o controller.

In some embodiments of haemodialysis equipment as herein described, described control unit is configured to from being received To weight signal calculate from described first intermediate receptacle and described both second intermediate receptacles be delivered to described output control The amount of the treatment solution of device processed.

On the other hand, control in haemodialysis equipment some embodiments of method for the treatment of solution stream can include with Lower step: utilize treatment solution to fill described the by treatment solution is carried the first intermediate receptacle from treatment source of solvent One intermediate receptacle, the amount of the treatment solution being weighed to determine described first intermediate receptacle in described first intermediate receptacle how Time be increased to selected fill level, and when the amount of the treatment solution in described first intermediate receptacle is increased to described selected Stop during fill level to described first intermediate receptacle conveying treatment solution；And filling institute from described treatment source of solvent While stating the first intermediate receptacle, treatment solution is delivered to o controller from the second intermediate receptacle, in described second Between the amount for the treatment of solution that is weighed to determine in described second intermediate receptacle of container when drop to selected refill level, And when the amount of the treatment solution in described second intermediate receptacle drop to described selected refill level time stop to institute State o controller conveying treatment solution.

Can be blood as herein described for putting into practice the haemodialysis equipment of some embodiments of method described herein Any one in the various embodiments of liquid therapeutic equipment.

In some embodiments, described method can comprise the following steps that by treating solution from described treatment solution Source carries described second intermediate receptacle and utilizes treatment solution to fill described second intermediate receptacle, holds in the middle of described second When the amount of the treatment solution that device is weighed to determine in described second intermediate receptacle is increased to selected fill level, and works as The amount of the treatment solution in described second intermediate receptacle is increased to during described selected fill level stop in described second Between container transport treatment solution；And will treatment while filling described second intermediate receptacle from described treatment source of solvent Solution is delivered to described o controller from described first intermediate receptacle, and described first intermediate receptacle is weighed to determine institute When the amount stating the treatment solution in the first intermediate receptacle drops to the selected level that refills, and in the middle of described first The amount of the treatment solution in container drops to described selecting and stops when refilling level controlling to the conveying of described o controller Treat solution.

In some embodiments, method described herein can comprise the following steps that to described first intermediate receptacle or While described second intermediate receptacle conveying treatment solution, change in the multiple supply reservoirs in described treatment source of solvent One or more supply reservoir.

In some embodiments, method described herein can comprise the following steps that to the first intermediate receptacle or second While intermediate receptacle conveying treatment solution, in treatment source of solvent, constitute treatment from treatment solution precursors and fluid supply molten Liquid.

In some embodiments of method described herein, treatment solution is essentially continuously delivered to export control Device.

In some embodiments, method described herein can comprise the following steps that in from treatment source of solvent to first Between container or the second intermediate receptacle conveying treatment solution time, make from treatment source of solvent treatment solution through air detection Device.

In some embodiments, method described herein can comprise the following steps that in from treatment source of solvent to first Between container or the second intermediate receptacle conveying treatment solution time, make from treatment source of solvent treatment solution through sterilising filtration Device.

In some embodiments of method described herein, fill the first intermediate receptacle or the step of the second intermediate receptacle Comprise the following steps: by source flux controller, treatment solution is pumped to the first intermediate receptacle or the from treatment source of solvent Two intermediate receptacles.

In some embodiments of method described herein, based on the first intermediate receptacle and the weight of the second intermediate receptacle Calculate the amount of the treatment solution being delivered to o controller from both the first intermediate receptacle and the second intermediate receptacle.

As used herein and in the appended claims, unless context clearly dictates otherwise, otherwise odd number shape Formula " one " and " described " also include most indicant.It is therefoie, for example, " one " or " described " assembly can include ability Assembly known to field technique personnel and one or more in equivalent thereof.It addition, term "and/or" means one Or all institute's column elements or any two or the combination of more institutes column element.

It should be noted that term " includes " and at these terms, modification occurs that position in the following description does not has Restrictive sense.Additionally, " one ", " described ", " at least one " and " one or more " are the most interchangeable Use.

Above summary of the invention be not intended to describe each embodiment of haemodialysis equipment as herein described or each Implementation.On the contrary, by referring to accompanying drawing with reference to detailed description below and claims, it will understand and recognize Know the more complete understanding to the present invention.

Accompanying drawing explanation

Fig. 1 illustrates known extracorporeal blood treatment equipment.

Fig. 2 illustrates an embodiment of extracorporeal blood treatment equipment as described herein.

Fig. 3 illustrates the first operator scheme of the extracorporeal blood treatment equipment of Fig. 2, wherein will treatment at the second intermediate receptacle While solution is delivered to o controller, fill the first intermediate receptacle from treatment source of solvent.

Fig. 4 illustrates the second operator scheme of the extracorporeal blood treatment equipment of Fig. 2, wherein will treatment at the first intermediate receptacle While solution is delivered to o controller, fill the second intermediate receptacle from treatment source of solvent.

Fig. 5 illustrates another embodiment of extracorporeal blood treatment equipment as described herein.

Fig. 6 illustrates the first operator scheme of the extracorporeal blood treatment equipment of Fig. 5, wherein will treatment at the second intermediate receptacle While solution is delivered to o controller, fill the first intermediate receptacle from treatment source of solvent.

Fig. 7 illustrates the second operator scheme of the extracorporeal blood treatment equipment of Fig. 5, wherein will treatment at the first intermediate receptacle While solution is delivered to o controller, fill the second intermediate receptacle from treatment source of solvent.

Fig. 8 illustrates another embodiment of extracorporeal blood treatment equipment as described herein.

Fig. 9 illustrates the first operator scheme of the extracorporeal blood treatment equipment of Fig. 8, wherein will treatment at the second intermediate receptacle While solution is delivered to o controller, fill the first intermediate receptacle from treatment source of solvent.

Figure 10 illustrates the second operator scheme of the extracorporeal blood treatment equipment of Fig. 8, wherein will control at the first intermediate receptacle While treatment solution is delivered to o controller, fill the second intermediate receptacle.

Figure 11 is shown in the weight change of the intermediate receptacle in the embodiment of haemodialysis equipment operation period Fig. 8.

Detailed description of the invention

In the following description of exemplary embodiment, with reference to forming one part and illustrating specific reality in a schematic way Execute the accompanying drawing of mode.It will be appreciated that other embodiment can be used, and without departing from the scope of the invention Structural change can be carried out.

In the various exemplary embodiment of Fig. 2, Fig. 5 and Fig. 8, it is shown that haemodialysis equipment 1.The blood illustrated Liquid therapy equipment 1 has the operative configuration that can perform hemodialysis.Certainly, in other embodiment Other treatment configuration (ultrafiltration, hemofiltration and hemodiafiltration) previously mentioned is also feasible, described herein Principle, system and method also apply be applicable to those embodiments.

Haemodialysis equipment 1 shown in Fig. 2, Fig. 5 and Fig. 8 includes filter 2, and this filter 2 has by half Main chamber 3 that permeable membrane 5 separates and secondary chamber 4.Blood circuit in haemodialysis equipment 1 includes being intended to from patient's blood drawing Arterial line 7, the main chamber 3 of filter and be intended to return to blood from main chamber 3 venous line 6 of patient.

In each embodiment, treatment solution (such as, dialysis solution etc.) is transported to haemodialysis equipment 1.By Treatment solution in each embodiment shown is dialysis solution, thus utilize o controller 31 by be connected to into Treatment solution is transported to the secondary chamber 4 of filter 2 by the treatment solution port 10 of mouth pipeline 9.By drainage line 8 From secondary chamber 4 liquid removing of filter 2.

Although o controller 31 is shown as the form of peristaltic pump in the embodiment of Fig. 2, Fig. 5 and Fig. 8, But o controller 31 can provide according to the various alternate forms that can be used in controlling the flow for the treatment of solution, bag Include such as other pump (such as, piston pump, membrane pump etc.), other flow control mechanism (such as, valve, clamp etc.) Deng.

Although each embodiment of the haemodialysis equipment shown in Fig. 2, Fig. 5 and Fig. 8 relates to by being connected to entrance Treatment solution (for example, form of dialysis solution) is delivered to the secondary of filter 2 by the treatment solution port 10 of pipeline 9 Room 4, but the most also other treatment solution can be fed directly to arterial line 7 and/or duct of Arantius Blood (or the most in some embodiments, being delivered to reside in the blood in main chamber 3) in road 6.

In other embodiments, haemodialysis equipment as described herein can include two or more different controlling Treat the identical or different position that solution is delivered in haemodialysis equipment.Such as, can be by the treatment solution of dialysis solution form As shown in the embodiment of Fig. 2, Fig. 5 and Fig. 8, be delivered to the secondary chamber 4 of filter, and by one or more of not Same treatment solution is delivered to the blood in such as main chamber 3, arterial line 7 and/or venous line 6.

In haemodialysis equipment as herein described by treatment solution delivery system conveying treatment solution utilize two or More intermediate receptacles are supplied.The weight of intermediate receptacle can treatment that is measured and that can be used for controlling in intermediate receptacle molten The refilling and emptying of liquid.In some embodiments, may also be based at least in part on intermediate receptacle weight and/or Weight change controls to be delivered to the amount of the treatment solution of the selected part of haemodialysis equipment.In the middle of two or more Treatment solution in container is supplied to intermediate receptacle from treatment source of solvent, and this can reduce potentially or eliminate in centre Vessel empty and/or stop conveying treatment solution when refilling to change the needs of intermediate receptacle.

In haemodialysis equipment as herein described, " intermediate receptacle " can take to store any suitable shape of liquid Formula, such as bag, bottle, reservoir etc..

In the embodiment of the haemodialysis equipment 1 shown in Fig. 2, Fig. 5 and Fig. 8, use the first intermediate receptacle 11 With the second intermediate receptacle 12, treatment solution being supplied to o controller 31, o controller 31 then will treatment Solution is supplied to treatment solution port 10 (in the illustrated embodiment, being connected to entrance pipe 9).First weight meter 21 are configured to weigh the first intermediate receptacle 11, and the instruction of described weight is contained in controlling in the first intermediate receptacle 11 Treat the amount of solution.Second weight meter 22 is configured to weigh the second intermediate receptacle 12, and the instruction of described weight is contained in The amount of the treatment solution in the second intermediate receptacle 12.

Another feature that the exemplary embodiment of the haemodialysis equipment shown in Fig. 2, Fig. 5 and Fig. 8 is common is control Unit 41 processed is linked to the first weight meter 21 and the second weight meter 22 and o controller 31.No matter there may be Or how the additional fluid flow may being not present in haemodialysis equipment as herein described controls assembly, control single Unit 41 may link to (beyond first weight meter the 21, second weight meter 22 and o controller 31) various fluids Flow control assembly so that while treating a solution outflow from intermediate receptacle (12,11), molten with treatment Liquid fills another in intermediate receptacle (11,12), and vice versa.

Control unit 41 can provide according to any suitable form, and may for instance comprise memorizer and controller. Described controller can be (such as) one or more microprocessor, special IC (ASIC) state machine Etc. form.Control unit 41 can include the various any suitable input equipment being configured to allow user operation equipment (such as, keyboard, touch screen, mouse, tracking ball etc.) and be configured to pass on the display device of information to user (such as, monitor (can be or can not be touch screen), display lamp etc.).

More particularly, haemodialysis equipment as herein described includes acting in the middle of the first intermediate receptacle 11 and second The o controller 31 in the downstream of container 12.Control unit 41 can be configured to control o controller 31 with in profit With haemodialysis equipment conveying treatment during to treatment solution port 10 provide treatment solution substantially continuous stream.Control Various fluid flows in control equipment control assembly and reservoir to provide treatment solution by treatment solution port 10 Substantially continuous stream (according to constant flow rate and/or according to the variable flow rate according to selected velocity flow profile).

It is supplied to the weight information of control unit 41 for monitoring the weight of the first intermediate receptacle 11 by the first weight meter 21 Amount, to know the amount of the treatment solution flowing out the first intermediate receptacle 11 and to utilize the threshold value (such as, 11.1 of two preliminary elections With 11.2) (can volume based on each intermediate receptacle set) control the first intermediate receptacle 11 and the second intermediate receptacle The filling of 12 and discharge phase.

Second weight meter 22 provides weight information to control unit 41, so that the second intermediate receptacle 12 can be monitored Weight.This weight information can be used for determining the amount of the treatment solution flowing out the second intermediate receptacle 12.This weight information is also Can be used for utilizing one or two threshold value (such as, 12.1 and 12.2) and the one of the first weight meter of the second weight meter Individual or two threshold values (11.1 and 11.2) control circulation filling and emission treatment.If using two threshold values to be enough to control Treatment liquid inventory controls, and the most in some embodiments, four threshold values of two weight meters can be used for other function, Such as relate to the prevention warning purposes etc. of the abnormality of bag.

In some embodiments, control unit 41 be configured to based on the weight signal that receives from weight meter calculate from Treatment source of solvent 60 be delivered to haemodialysis equipment treatment solution amount, described weight meter be configured to for Each intermediate receptacle of o controller 31 conveyance fluid is weighed (in the illustrated embodiment, including the first weight meter With the second weight meter (21 and 22), but if plural intermediate receptacle is for feeding to o controller 31, Then can include more weight meter).

Each exemplary embodiment of haemodialysis equipment shown in Fig. 2, Fig. 5 and Fig. 8 includes treating source of solvent 60, This treatment source of solvent 60 provides treatment solution to intermediate receptacle, and intermediate receptacle is subsequently used in be supplied to o controller 31 Treatment solution.Treatment source of solvent 60 is in fluid communication with container selection control 32, and this container selection control 32 can Which for according to intermediate receptacle needing to refill, treatment solution is held in the middle for the treatment of source of solvent 60 guides to first Device 11 or the second intermediate receptacle.Treatment solution is supplied to container by source flux controller 33 by treatment source of solvent 60 Selection control 32.

Although source flux controller 33 is shown as the form of peristaltic pump in the embodiment of Fig. 2, Fig. 5 and Fig. 8, But source flux controller 33 can provide according to the various alternate forms that can be used in controlling the flow for the treatment of solution, Including such as other pump (such as, piston pump, membrane pump etc.), other flow control mechanism (such as, valve, clamp Deng) etc..

In the embodiment shown in figure 2, treatment source of solvent 60 in treatment solution can include multiple reservoir 61, 62,63, these reservoirs can be separately replaced to guarantee that treating source of solvent 60 can continue to select to control to container Device 32 provides treatment solution.Reservoir 61,62,63 can take any form being suitable for accommodating conveying liquid, example Such as bag, bottle etc..Reservoir 61,62,63 may be adapted to single use (they will be disposed off subsequently), but stores Storage 61,62,63 can be recharged when also can treat solution with conveying in being not attached to treat source of solvent 60.

In some embodiments, all reservoirs 61,62,63 can be in fluid communication with source flux controller 33 simultaneously, But in other embodiments, optionally one or more in reservoir 61,62,63 is set to Be in fluid communication with source flux controller 33, and in reservoir 61,62,63 one or more not with source flux control Device 33 processed is in fluid communication that (they can such as disconnect, or fluid circuit is by valve, clamp or other flow controller And close).

Although the treatment source of solvent 60 shown in Fig. 2 includes three reservoirs 61,62,63, but other embodiment The available reservoir arriving one or two less operates, and other embodiment treating source of solvent can be provided with four Or more accommodate treatment solution reservoir.It addition, in some embodiments, reservoir can all accommodate identical The liquid of volume, or they can accommodate the treatment solution of different volumes.

In some embodiments, treatment source of solvent 60 includes that monitor 66 filled by reservoir, and it is configured to monitoring The occupied state (monitoring or together monitoring respectively) of reservoir 61,62,63.Fill monitor 66 and may utilize any The suitably combination of technology or technology (such as, utilizes weight, utilizes capacitance sensor, optical pickocff or other biography Sensor, utilize fluid pressure (such as, the fluid pressure in pipeline 44) etc.) monitor fluid volume.Fill prison Survey device 66 and can the most operationally link to control unit 41 so that when reservoir 61,62,63 needs by again During filling, haemodialysis equipment 1 can provide warning or instruction (such as, vision, audition etc.), so that can take Suitably action.If monitoring the occupied state of reservoir 61,62,63 together, then when reservoir 61,62,63 In the total amount for the treatment of solution reach the selected lower limit (maximum of the treatment solution that such as, will accommodate in three reservoirs 1/3) time (meaning that at least one in reservoir 61,62,63 may need to be replaced, refill), can Activate any warning or instruction.

Another optional feature in the embodiment of the haemodialysis equipment 1 shown in Fig. 2, Fig. 5 and Fig. 8 is air inspection Surveying device 70, it can be located at from treatment source of solvent 60 to the fluid delivery pipeline 44 of source flux controller 33.Air Detector 70 can be used for the air before it arrives source flux controller 33 in signal piping 44.Now, operation Member can take suitable action to change the reservoir of any sky in treatment source of solvent 60, or takes to find pipeline 44 In air reason needed for other suitable action any.

If air being detected by air monitor 70, the most in some embodiments, control unit 41 is (behaviour Air monitor 70 and source flux controller 33 it is connected on work) reverse operating source flux controller 33 can be configured to, Make the treatment solution in pipeline 44 can refill the fluid circuit being back to treat source of solvent 60.It is being arranged to In the system of this reverse operating, intermediate receptacle (such as, first intermediate receptacle in container selection control 32 downstream 11 and second intermediate receptacle 12) should be from the underfill of intermediate receptacle so that reverse at source flux controller 33 During operation can by for fill the identical pipeline of intermediate receptacle therefrom between the treatment extracted out in intermediate receptacle of container molten Liquid, be adapted to assist in the treatment solvent portions of extraction refill intermediate receptacle (11 or 12) with treatment source of solvent 60 it Between fluid circuit.

Another optional feature in the embodiment of the haemodialysis equipment 1 shown in Fig. 2, Fig. 5 and Fig. 8 is sterilizing Filter 80.Sterilising filter 80 can be located in the fluid delivery path of container selection control 32 upstream.At some In embodiment, sterilising filter 80 can be located at the downstream of source flux controller 33 (that is, between flow controller Between 33 and container selection control 32), but other position is also feasible (such as, flow controller 33 Upstream).It is molten that sterilising filter 80 is provided for reducing the treatment being contaminated to container selection control 32 conveying Liquid thus flow to the probability of the intermediate receptacle for supplying o controller 31.

In some embodiments, sterilising filter 80 can include air vent (such as, the passive row of hydrophobic membrane form QI KOU) to help to remove the air that may become entrained in treatment solution.

In some embodiments, sterilising filter 80 can be located at the downstream of source flux controller 33.By filter 80 downstreams being arranged on flow controller 33 can be avoided generating negative pressure in the pipeline 44 that flow controller 33 feeds And any relevant fluid degassing that can thus cause.

In operation, the control list in the exemplary embodiment of the haemodialysis equipment shown in Fig. 2, Fig. 5 and Fig. 8 Unit 41 can be able to receive that from the first weight meter 21 and/or weight information of the second weight meter 22, calculates and is delivered to control Treat the actual flow velocity of the treatment solution of solution port 10, by this actual flow velocity and selected constant flow rate or with selected Velocity flow profile compare, and utilize fluid flow o controller 31, source flux controller 33 and/or can arrange Other fluid flow control mechanism any (such as, pump, valve, clamp etc.) in haemodialysis equipment as herein described Control the actual flow velocity for the treatment of solution.

Control unit 41 is also configured to during treating solution to treatment solution port 10 conveying, from the first weight Count 21 and/or receive weight information from the second weight meter 22, determining the occupied state of each intermediate receptacle, based on respectively The occupied state of individual intermediate receptacle controls alternately and continuous print intermediate receptacle loads and emission treatment.Such as, control unit 41 can be configured to receive weight information from the first weight meter 21 and/or from the second weight meter 22, detect in the middle of each The upper and lower bound threshold value (such as, 11.2,11.1,12.2,12.1) of container, and based on threshold value according to following process Control intermediate receptacle filling and discharge program: the first intermediate receptacle 11 is loaded into upper limit threshold (such as, 11.1), And the second intermediate receptacle 12 is discharged until the lower threshold (such as, 12.2) of the second intermediate receptacle 12 being detected, Then the first intermediate receptacle 11 is discharged until its lower threshold (such as, 11.2) being detected, and hold in the middle of second Device 12 is filled to its upper limit threshold (such as, 12.1).

In order to carry treatment solution continuously to port 10, should be more than first from the rate of flow of fluid of source flux controller 33 The speed of intermediate receptacle 11 and the discharge of the second intermediate receptacle 12 is (corresponding to defeated by port 10 by o controller 31 The flow velocity of the treatment solution sent).Maintain this flow velocity relation generally it should be ensured that reach it at the intermediate receptacle being just discharged Before lower threshold, the intermediate receptacle being just loaded reaches its upper limit threshold.In some embodiments, if passed through The flow velocity of the treatment solution of source flux controller 33 conveying is less than the flow velocity from o controller 31 to port 10, then Generally stop the flowing by port 10 once in a while by needing, to allow intermediate receptacle to refill.

With reference to the exemplary embodiment of haemodialysis equipment as in Figure 2-4, equipment 1 include as herein described not The assembly that common and in haemodialysis equipment 1 treatment solution conveying is relevant with embodiment.These total assemblies Control including first intermediate receptacle the 11, second intermediate receptacle the 12, first weight meter the 21, second weight meter 22, output Device 31, container selection control 32, source flux controller 33, control unit 41, treatment source of solvent 60, air Detector 70 and sterilising filter 80.

In this embodiment, container selection control 32 includes exporting 51 and entrance 52.Treatment solution is from treatment Source of solvent 60 (through source flux controller 33) is flowed in container selection control 32 by entrance 52.Treat molten Liquid flows in o controller 31 by exporting 51 flow container selection controls 32.Container selection control Various assemblies in 32 allow selectivity filling and the discharge of the first intermediate receptacle 11 and the second intermediate receptacle 12, with Time also provide for maintaining treatment solution by outlet the 51 substantially continuous abilities flowing to o controller 31.

In container selection control 32, the first pipeline 57 holds in the middle of outlet 51 and the first intermediate receptacle and second Each in two delivery outlets (53 and 55) of device (11 and 12) connects.Flow controller (122 and 124) It is arranged to act on the first pipeline 57 between delivery outlet (53 and 55) and outlet 51, to allow or to stop Flow to export 51 by the first pipeline 57.Although being shown schematically as clamp, flow controller (122 and 124) Can be the forms such as (such as) valve, clamp, pump.

Container selection control 32 shown in Fig. 2 also includes making entrance 52 and the first intermediate receptacle and the second intermediate receptacle Second pipeline 58 of each fluid communication in two input ports (54 and 56) of (11 and 12).Flow control Device processed (121 and 123) is arranged to act on the second pipeline 58 between entrance 52 and input port (54 and 56) On, to allow or to stop treatment solution to flow to input port (54 and 56) through the second pipeline 58.Although by schematically Be shown as clamp, flow controller (121 and 123) can be the forms such as (such as) valve, clamp, pump.

In the operation of haemodialysis equipment 1, by controlling the various flow controllers in container selection control 32 The first intermediate receptacle 11 and the second intermediate receptacle 12 is alternately loaded and discharged in (121,122,123,124), So that the substantially continuous stream for the treatment of solution can be provided to the outlet 51 fed for o controller 31.Fig. 3 and Fig. 4 The operation of haemodialysis equipment 1 is shown so that intermediate receptacle (11 and 12) can pass through the first pipeline and the second pipeline (57 and 58) alternately load and discharge.

In figure 3, flow controller 121 is opened, and flow controller 123 cuts out.As a result, treatment solution can be from source Flow controller 33 is flowed in the first intermediate receptacle 11 by the second pipeline 58, but due to the flow controller closed 123 and be prevented from flowing in the second intermediate receptacle 12.Flow in the configuration shown in Fig. 3, on the first pipeline 57 Controller 122 cuts out, and flow controller 124 is opened.As a result, treatment solution can pass through from the second intermediate receptacle 12 First pipeline 57 flows to o controller 31, but is prevented from flow through in first due to the flow controller 122 of closedown Between container 11.Therefore, the configuration shown in Fig. 3 can be described as the first intermediate receptacle 11 and filled out by the second pipeline 58 Fill or load, and the second intermediate receptacle 12 is being emptied or the configuration of discharge by the first pipeline 57.

Fig. 4 illustrates the different configurations of the haemodialysis equipment 1 of Fig. 2, and wherein the first intermediate receptacle 11 is emptying or row Put, and the second intermediate receptacle 12 is filled or loads.Specifically, in the configuration of Fig. 4, flow controller 123 Opening, flow controller 121 cuts out.As a result, treatment solution can be from source flux controller 33 by the second pipeline 58 Flow in the second intermediate receptacle 12, but be prevented from flowing to the first intermediate receptacle due to the flow controller 121 of closedown In 11.In the configuration shown in Fig. 4, flow controller 124 is also switched off, and flow controller 122 is opened.As a result, Treatment solution can flow to o controller 31 from the first intermediate receptacle 11 by the first pipeline 57, but due to closedown Flow controller 124 and be prevented from flow through the second intermediate receptacle 12.

In some embodiments, control unit 41 can be configured to control container selection control 32 so that according to The mode providing the stream continuously for the treatment of solution to o controller 31 (therefore, to port 10) realizes Fig. 3 and Fig. 4 The shown conversion between configuration.Such as, when switching between the configuration shown in Fig. 3 and Fig. 4, in flow-control Before a closedown in device, the flow controller 122 and 124 on the first pipeline 57 is opened the most simultaneously.

In some embodiments of haemodialysis equipment as herein described, flow to the treatment solution of o controller 31 Short interruption (such as, 60 seconds or shorter) can be to allow, and can be considered and " substantially connecting as described herein Continuous " treatment solution conveying definition in.

Control unit 41 can be configured to control o controller 31 according to different configurations.In one configuration, when (and such as, another intermediate receptacle is at quilt in discharge in only first intermediate receptacle 11 or the second intermediate receptacle 12 one Fill) time, control unit 41 controls defeated based on the weight information from the first weight meter 21 or the second weight meter 22 Go out controller 31, container selection control 32 and source flux controller 33 to realize by treatment solution port 10 The selected velocity flow profile for the treatment of solution.In other words, the flow velocity by the treatment solution of o controller 31 is in first Between the function of rate of change for the treatment of amount of solution in container 11 or the second intermediate receptacle 12.Weight meter (21 or 22) Select based on now discharge be which intermediate receptacle (11 or 12).

In another configures, control unit 41 is based on from both the first weight meter and the second weight meter (21,22) Weight information control o controller 31, container selection control 32 and source flux controller 33 to realize passing through The selected velocity flow profile of the treatment solution for the treatment of solution port 10.Such as, all beat when flow controller 122 and 124 Open so that treatment solution can be delivered to the first pipeline 57 from both the first intermediate receptacle 11 and the second intermediate receptacle 12 Time this can be used to configure.

With reference to the exemplary embodiment of haemodialysis equipment as illustrated in figs. 5-7, equipment 1 include as herein described not The assembly that common and in haemodialysis equipment 1 treatment solution conveying is relevant with exemplary embodiment.These are altogether Assembly is had to include first intermediate receptacle the 11, second intermediate receptacle the 12, first weight meter the 21, second weight meter 22, defeated Go out controller 31, container selection control 32, source flux controller 33, control unit 41, treatment source of solvent 60, Air monitor 70 and sterilising filter 80.

In this embodiment, container selection control 32 also includes exporting 51 and entrance 52.Treatment solution contrary treatment Treat source of solvent 60 (through source flux controller 33) to be flowed in container selection control 32 by entrance 52.Treatment Solution flows in o controller 31 by exporting 51 flow container selection controls 32.Container selects to control Various assemblies in device 32 allow selectivity filling and the discharge of the first intermediate receptacle 11 and the second intermediate receptacle 12, Also provide for maintaining treatment solution by the outlet 51 substantially continuous abilities flowing to o controller 31 simultaneously.

In container selection control 32, the first pipeline 57 holds in the middle of outlet 51 and the first intermediate receptacle and second Each in two delivery outlets (53 and 55) of device (11 and 12) connects.Flow controller 125 is arranged to Act on the delivery outlet (53 and 55) on the first intermediate receptacle and the second intermediate receptacle (11 and 12) and outlet 51 Between the first pipeline 57 on, with allow or stop flow to export 51 by the first pipeline 57.Flow controller 125 Can be (such as) multiport flow controller, it can configure between at least two is alternately arranged, and wherein, permits Permitted by outflows from delivery outlet (53 and 55) of first pipeline 57, and prevention by the first pipeline 57 from Another delivery outlet flows out.In some embodiments, multiport flow controller 125 can have the 3rd configuration, wherein, Allow to be flowed out from two delivery outlets (53 and 55) by the first pipeline 57.Multiport flow controller 125 can be according to The form such as banked direction control valves, grip module provides.In some embodiments, multiport flow controller 125 can be such as Fig. 5 Shown in be operationally linked to control unit 41 so that control unit 41 can be used for multiport flow controller 125 Switch between its various configurations.

Container selection control 32 shown in Fig. 5 also includes making entrance 52 and the first intermediate receptacle and the second intermediate receptacle Second pipeline 58 of each fluid communication in two input ports (54 and 56) of (11 and 12).Stream is set Amount controller 126 is to allow or to stop treatment solution to flow through the second pipeline 58.Flow controller 126 can be (example As) form of multiport flow controller, it can configure, wherein between at least two is alternately arranged, it is allowed to logical Cross the second pipeline 58 and flow in input port (54 and 56), and stop and flow to another by the second pipeline 58 Its input port.In some embodiments, multiport flow controller 126 can have the 3rd configuration, wherein, it is allowed to Two input ports (54 and 56) are flowed to by the second pipeline 58.Multiport flow controller 126 can according to banked direction control valves, The forms such as grip module provide.In some embodiments, multiport flow controller 126 can be as shown in Figure 5 behaviour Control unit 41 it is linked to so that control unit 41 can be used for various at it for multiport flow controller 126 on work Switch between configuration.

In the operation of haemodialysis equipment 1, by controlling the flow controller (125 in container selection control 32 With 126) alternately load and discharge the first intermediate receptacle 11 and the second intermediate receptacle 12, so that can be to for defeated The outlet 51 going out controller 31 feeding provides the substantially continuous stream for the treatment of solution.Fig. 6 and Fig. 7 illustrates that haemodialysis sets The operation of standby 1 so that intermediate receptacle (11 and 12) can be replaced by the first pipeline and the second pipeline (57 and 58) Ground filling and discharge.

In figure 6, flow controller 126 is configured to allow treatment solution from source flux controller 33 by second Pipeline 58 flows in the first intermediate receptacle 11, and stops treatment solution to flow in the second intermediate receptacle 12.At Fig. 6 In shown embodiment, flow controller 125 is configured to allow treatment solution to pass through from the second intermediate receptacle 12 First pipeline 57 flows to o controller 31, and stops treatment solution to flow out the first intermediate receptacle 11.Therefore, Fig. 6 Shown configuration can be described as the first intermediate receptacle 11 and be filled by the second pipeline 58 or loaded, and holds in the middle of second Device 12 is being emptied or the configuration of discharge by the first pipeline 57.

Fig. 7 illustrates the different configurations of the haemodialysis equipment 1 of Fig. 5, wherein, the first intermediate receptacle 11 in emptying or Discharge, and the second intermediate receptacle 12 is filled or loads.Specifically, in the configuration of Fig. 7, flow controller 126 are configured such that treatment solution can flow to the second intermediate receptacle from source flux controller 33 by the second pipeline 58 In 12, and treatment solution is stoped to flow in the first intermediate receptacle 11.In the embodiment shown in figure, flow control Device 125 processed is configured to allow treatment solution to flow to o controller from the first intermediate receptacle 11 by the first pipeline 57 31, and stop treatment solution to flow out the second intermediate receptacle 12 by the first pipeline 57.Therefore, the configuration shown in Fig. 7 The first intermediate receptacle 11 can be described as by the first pipeline 57 in emptying or discharge, and the second intermediate receptacle 12 leads to Cross the second pipeline 58 in the configuration being packed or filled with.

In some embodiments, control unit 41 can be configured to control container selection control 32 so that according to Therapy discontinued solution does not flows to the mode of o controller 31 and realizes the conversion between the configuration shown in Fig. 6 and Fig. 7. Such as, in some embodiments, when switching between the configuration shown in Fig. 6 and Fig. 7, flow controller 125 Can allow to treat solution to flow to control by the first pipeline 57 from both the first intermediate receptacle 11 and the second intermediate receptacle 12 Treat solution output flow controller 31.

Control unit 41 can be configured to control o controller 31 according to different configurations.In one configuration, when (and such as, another intermediate receptacle is at quilt in discharge in only first intermediate receptacle 11 or the second intermediate receptacle 12 one Fill) time, control unit 41 controls defeated based on the weight information from the first weight meter 21 or the second weight meter 22 Go out controller 31, container selection control 32 and source flux controller 33 to realize by treatment solution port 10 The selected velocity flow profile for the treatment of solution.In other words, the flow velocity by the treatment solution of o controller 31 is in first Between the function of rate of change for the treatment of amount of solution in container 11 or the second intermediate receptacle 12.Weight meter (21 or 22) Select based on now discharge be which intermediate receptacle (11 or 12).

In another configures, control unit 41 is based on from both the first weight meter and the second weight meter (21,22) Weight information control o controller 31, container selection control 32 and source flux controller 33 to realize passing through The selected velocity flow profile of the treatment solution for the treatment of solution port 10.Such as, if flow controller 125 allows treatment Solution flows through the first pipeline 57 from both the first intermediate receptacle 11 and the second intermediate receptacle 12, then this can be used to configure.

Generally, o controller 31 is configured to treat solution port according to the conveying treatment of dialysis fluid flow velocity Solution；To this end, control unit 41 be configured to receive dialysis fluid flow velocity setting value (such as, from user interface, This user interface is arranged for receiving the setting value of dialysis fluid flow velocity from operator), control o controller subsequently 31 so that treatment solution is according to the dialysis fluid flow rate corresponding with treatment solution port 10.

In other words, by doctor treat time set dialysis fluid flow velocity, and control machine so that output control Device processed (that is, pump) is actuated to tend to the fluid that conveying sets.

More particularly, control unit 41 is configured to based on from the first weight meter 21 and the second weight meter 22 Weight signal controls o controller 31 so that treatment solution is according to dialysis fluid flow rate.

At the first intermediate receptacle 11 to filter and/or directly under the first mode of blood offer fluid, control unit 41 are configured to control o controller 31 based on the weight signal from the first weight meter 21 so that treating solution According to dialysis fluid flow rate.In the flrst mode, the weight signal from another weight meter 22 is used for monitoring logical Cross the new supply treating fluid of source flux controller；Therefore, in the flrst mode, control unit 41 is configured to Do not using control o controller 31 in the case of the weight signal of the second weight meter 22.

At the second intermediate receptacle 12 to filter and/or directly under the second pattern of blood offer fluid, control unit 41 are configured to control o controller 31 based on the weight signal from the second weight meter 22 so that treating solution According to dialysis fluid flow rate.

Under the second mode, the weight signal from another weight meter 21 is used for monitoring by source flux controller 33 The new supply treating fluid；Therefore, under the second mode, control unit 41 is configured to do not using from O controller 31 is controlled in the case of the weight signal of one weight meter 21.

In order to realize treatment prescription, control unit 41 is configured to during treating the course for the treatment of at first mode and the second mould Alternately switch repeatedly between formula.

Additionally, generally, control unit 41 is configured to control source flux controller 33 during treating and is higher than to provide The rate of flow of fluid of the dialysis fluid flow velocity that (or being at most equal to) is provided by o controller 31.

It is treatment source of solvent 60 in conjunction with the another feature shown in the embodiment of the haemodialysis equipment 1 of Fig. 5, not Including the multiple reservoirs treating solution described in embodiment as explained in connection with fig.2, this treatment source of solvent 60 includes Fluid supply 67, treatment solution precursors 68 and mixing apparatus 69, this mixing apparatus 69 is configured to from fluid supply The liquid (such as, water, suitable aqueous solution etc.) of 67 and treatment solution precursors 68 (such as, the concentration of dialysis solution Solution etc.) combine to form treatment solution.Different from the treatment source of solvent 60 of Fig. 2, utilize the treatment solution of Fig. 5 The treatment solution of source 60 conveying is not to provide in reservoir, but on the contrary, forms in treatment source of solvent 60.

With reference to the exemplary embodiment of haemodialysis equipment as seen in figs. 8-10, equipment 1 includes as herein described The assembly that common and in haemodialysis equipment 1 the treatment solution conveying of different exemplary embodiment is relevant.These Total assembly include first intermediate receptacle the 11, second intermediate receptacle the 12, first weight meter the 21, second weight meter 22, O controller 31, container selection control 32, source flux controller 33, control unit 41, treatment source of solvent 60, air monitor 70 and sterilising filter 80.

In the embodiment shown in Fig. 8-10, control in the first intermediate receptacle 11 and second in part with gravity Between the filling of container 12 and discharge.Specifically, control unit is held middle relative to second for the first intermediate receptacle 11 The upright position of device 12 is applied in combination with container selection control 32, o controller 31 and source flux controller 33, Optionally to load and to discharge the first intermediate receptacle 11 and the second intermediate receptacle 12.

Source flux controller 33 is connected to o controller 31 by fluid circuit 157.First intermediate receptacle 11 leads to Crossing fluid circuit 152 to be in fluid communication with fluid circuit 157, this fluid circuit 152 is connected to fluid at joint 153 Pipeline 157.Second intermediate receptacle 12 is in fluid communication with fluid circuit 157 by fluid circuit 154, this fluid hose Road 154 is connected with fluid circuit 157 at joint 155.In the embodiment shown, container selection control 32 position along the fluid circuit 157 between joint 153 and 155.

By the first intermediate receptacle 11 is positioned at than the second intermediate receptacle 12 in the haemodialysis equipment shown in Fig. 8 Higher upright position uses gravity.In some embodiments, the upper limit of the second intermediate receptacle 12 is (such as, 12.1) lower limit (such as, 11.2) of ratio the first intermediate receptacle 11 is low or they are in identical level.At blood In the operation of therapeutic equipment 1, come alternately by controlling container selection control 32 with source flux controller 33 Filling and discharge the first intermediate receptacle 11 and the second intermediate receptacle 12, control so that can provide to o controller 31 Treat the substantially continuous stream of solution.

Fig. 9 and Figure 10 illustrates the operation of the haemodialysis equipment 1 shown in Fig. 8 so that can pass through fluid circuit 152, 154 and 157 alternately load and discharge intermediate receptacle (11 and 12).In fig .9, container selection control 32 Close.As a result, treatment solution flows to hold in the middle of first by fluid circuit 152 and 157 from source flux controller 33 In device 11, and stop treatment solution to flow through container selection control 32 and arrive the second intermediate receptacle 12 or output control Device 31.As a result, in the configuration shown in Fig. 9, the treatment solution from source flux controller 33 is filled or filling the One intermediate receptacle 11.Owing to container selection control 32 is closed in fig .9, so in the second intermediate receptacle 12 Treatment solution flows out the second intermediate receptacle 12 and flows to o controller 31.Therefore, the configuration shown in Fig. 9 can be retouched Stating is that the first intermediate receptacle 11 is filled or loads, and the second intermediate receptacle 12 is in emptying or the configuration of discharge.

Figure 10 illustrates the different configurations of the haemodialysis equipment 1 of Fig. 8, wherein, the first intermediate receptacle 11 in emptying or Discharge, and the second intermediate receptacle 12 utilizes treatment solution to fill or filling.Specifically, in the configuration of Figure 10, Source flux controller 33 stops or cutting out so that does not treat solution and is transported to fluid circuit by flow controller 33 In 157, and container selection control 32 is opened.Owing to the first intermediate receptacle 11 is higher than the second intermediate receptacle 12, So treatment solution will flow to fluid circuit 157 from the first intermediate receptacle 11 with in o controller 31 and second Between both containers 12 conveying treatment solution.Beyond the solution removed from fluid circuit 157 by o controller 31 from First intermediate receptacle 11 introduces the treatment solution of fluid circuit 157 and will flow in the second intermediate receptacle 12.Therefore, figure Configuration shown in 10 can be described as the first intermediate receptacle 11 by fluid circuit 157 in emptying or discharge, and second Intermediate receptacle 12 is in the configuration being packed or filled with.

Continuing to flow through o controller 31 in order to ensure treatment solution, three below flow velocity must is fulfilled for some flow velocity bars Part: from the flow velocity (Q33) of source flux controller 33, by the flow velocity (Q31) of o controller 31 and again Fill the weight-driven flow velocity of the interior treatment solution from the first intermediate receptacle 11 to the second intermediate receptacle 12 of circulation time Average (Q2g) (this flows to exist only in the operation shown in Figure 10 in the second intermediate receptacle 12 by pipeline 154 In configuration).

Continuing to flow through two conditions that o controller 31 should meet is: 1) source stream should be more than output stream, i.e. Q33>Q31；And 2) weight-driven flow velocity Q2g is sufficiently large to fill in time the second intermediate receptacle 12, the most still to O controller 31 feeds, i.e. Q2g > (Q31/ (Q33/ (Q31-1)).

If from the flow velocity of source flux controller 33 higher than by three times of the flow velocity of o controller 31 (i.e., Q33 > (3 × Q31)), then from the weight-driven stream of the treatment solution of first intermediate receptacle the 11 to the second intermediate receptacle 12 Speed (Q2g) should be at least by the half (that is, Q2g > (Q31/2)) of the desired flow rate of o controller 31.

If from the flow velocity of source flux controller 33 higher than by 1.5 times of the flow velocity of o controller 31 (i.e., Q33 > (1.5 × Q31)), then from the weight-driven stream of the treatment solution of the first intermediate receptacle 11 to the second intermediate receptacle 12 Speed (Q2g) should be at least by the twice (that is, Q2g > (2 × Q31)) of the desired flow rate of o controller 31.

Figure 11 represents the embodiment for the haemodialysis equipment shown in Fig. 8-10, according in the first for the treatment of time Between the weight change of container and the second intermediate receptacle, wherein the time (second) represents along X or trunnion axis, weight (gram) Represent along Y or vertical axis.

From the beginning of the particular example of Figure 11, will now describe before the system ready stage, during drainage cycle Continuous two stages or step.When starting the course for the treatment of, record two intermediate receptacles the most empty (such as, about 80 The weight of gram (g)), perform the preproduction phase.

Control unit makes source flux controller 33 preparation, opens container selection control 32, and does not operate output control Device 31 processed so that do not remove treatment solution by fluid o controller 31 from fluid circuit 157.

Source flux controller 33 controls treatment solution and flows to fluid circuit 157 from treatment source of solvent 60.

Second intermediate receptacle 12 relative to the first intermediate receptacle 11 in the downstream of source flux controller 33, but than The position that one intermediate receptacle 11 is low.Owing to the second intermediate receptacle 12 to the first intermediate receptacle 11 is low, so in second Between container 12 utilized before the first intermediate receptacle 11 treatment solution filling.Thus, it can be seen that hold in the middle of second The weight of the first intermediate receptacle 11 that the weight (PE2 on Figure 11) of device 12 is constant relative to holding is (on Figure 11 PE1) preferentially increase regularly.

Along with the second intermediate receptacle 12 reaches selected weight (such as, in the illustrated embodiment, about 280g), Haemodialysis equipment 1 is by according to first stage operation as shown in Figure 9: source flux controller 33 continues conveying treatment Solution, container selection control 32 is closed, and operable o controller 31 is with molten to port 10 conveying treatment Liquid.

Can as can be seen from Figure 9, the second intermediate receptacle 12 will discharge, in fluid circuit 157 in fluid circuit 157 Treatment solution will be transported to o controller 31 to start to treat the course for the treatment of with (such as).It can be seen that in the middle of second The weight of container 12 reduces (such as, from about 280g to about 120g) regularly.

Also can as can be seen from Figure 9, the first intermediate receptacle 11 utilizes the treatment solution from source flux controller 33 to load. It can be seen that the weight of the first intermediate receptacle 11 increases (such as, increasing to about 680g from 80g).

Perform this first stage until reaching the minimum weight threshold value of the second intermediate receptacle 12 (such as, in shown reality Execute in mode, about 120g), or reach the maximum weight threshold value of the first intermediate receptacle (such as, in shown reality Execute in mode, 680g), or reach first threshold value in above-mentioned two threshold value.

When this threshold value being detected, control unit controls to enter the second stage shown in Figure 10.

In second stage, treatment solution flows out the first intermediate receptacle 11 (decline such as the weight of the first intermediate receptacle 11 Indicated), treatment solution flows to the (increase such as the weight of the second intermediate receptacle 12 in the second intermediate receptacle 12 simultaneously Indicated).In this stage, control unit 41 opens container selection control 32, and stops from source flux control Device 33 flows out treatment solution and (in some embodiments, stopped source flux before opening container selection control 32 Controller 33).As a result, during the treatment solution from the first intermediate receptacle 11 flows to the second intermediate receptacle 12 and flow to O controller 31.

This second stage continues, until the first intermediate receptacle 11 reaches selected minimum weight (such as, shown In embodiment, about 100g) or the second intermediate receptacle 12 reach selected maximum weight (such as, shown Embodiment in, about 590g).

At the end of second stage, system switches back into the first stage, wherein source flux controller 33 conveying treatment solution And container selection control 32 is closed, o controller 31 is to port 10 conveying treatment solution simultaneously.

Owing to container selection control 32 is closed, the second intermediate receptacle 12 discharge is transported to controlling of o controller 31 Treat solution with continual cure course for the treatment of.It can be seen that the weight of the second intermediate receptacle 12 reduce regularly (such as, from About 590g is decreased to about 120g).

On the other hand, the first intermediate receptacle 11 utilizes the treatment solution from source flux controller 33 to load.Can see Weight to the first intermediate receptacle 11 increases (such as, increasing to about 680g from 80g).

It should be noted that before second container 12 reaches its selected minimum threshold, the first intermediate receptacle 11 reaches To the max-thresholds (such as, about 680g) that it is selected.As a result, stablizing such as the first intermediate receptacle in Figure 11 Shown in (constant) weight, the conveying of the treatment solution in the first intermediate receptacle 11 stops.Alternatively, can be After one intermediate receptacle 11 reaches max-thresholds that it is selected, (will occur at the second intermediate receptacle, to reach it selected Before little threshold value (such as, in the embodiment shown in Figure 11, about 400g or less)) any time Trigger the operation switching back into second stage.

When reaching the minimum weight threshold value of second container, then system can entrance second stage as described herein operate, Wherein based on the first intermediate receptacle 11 and the minimum threshold of the second intermediate receptacle 12 and max-thresholds in the first stage and Switching between two-stage, terminating the course for the treatment of until treating.

Discuss the exemplary embodiment of haemodialysis equipment and using method thereof, and have references to change.? Without departing from the scope of the invention, to those skilled in the art the present invention these and other change and Amendment will be apparent to, it should be appreciated that the invention is not restricted to exemplary embodiment described in this paper.Therefore, originally Invention will only be limited by claims provided below and equivalents thereof.

Claims (25)

1. a haemodialysis equipment (1), this haemodialysis equipment (1) including:

Blood circuit, it includes being intended to extract the arterial line (7) of blood from patient and be intended to return to blood the venous line (6) of described patient；

Filter (2), it has the main chamber (3) and secondary chamber (4) separated by semipermeable membrane, wherein, described blood circuit is configured to make blood through described main chamber (3), and wherein, described haemodialysis equipment (1) includes that the drainage line (8) leaving described secondary chamber (4) is to remove used dialysis solution from described secondary chamber；And

Treatment solution delivery system, it has treatment solution port (10), and be configured in described haemodialysis equipment (1) carry treatment solution by described treatment solution port (10) to described secondary chamber (4) and/or described blood circuit, wherein, described treatment solution delivery system includes:

First intermediate receptacle (11)；

First weight meter (21), it is configured to weigh described first intermediate receptacle (11)；

Second intermediate receptacle (12)；

Second weight meter (22), it is configured to weigh described second intermediate receptacle (12)；

Treatment source of solvent (60)；

Source flux controller (33), it is configured to from described treatment source of solvent (60) to described first intermediate receptacle (11) weighed by described first weight meter (21) and described second intermediate receptacle (12) the conveying treatment solution weighed by described second weight meter (22)；

Sterilising filter (80), this sterilising filter (80) is positioned between described treatment source of solvent (60) and described treatment solution port (10), make to be delivered to the treatment solution of described treatment solution port (10) through described sterilising filter (80) from described treatment source of solvent (60), wherein, described sterilising filter (80) is positioned at the downstream of described source flux controller (33)；

O controller (31), it is configured to control from described first intermediate receptacle (11) and described second intermediate receptacle (12) to the flowing treating solution of described treatment solution port (10)；

Container selection control (32), it is positioned in the treatment solution path between described source flux controller (33) and described o controller (31)；

Control unit (41), it is operationally attached to described first weight meter (21), described second weight meter (22), described source flux controller (33), described container selection control (32) and described o controller (31), wherein, described control unit (41) is configured to:

Weight signal is received from described first weight meter (21) and described second weight meter (22)；

Control described source flux controller (33), described container selection control (32) and described o controller (31) in the flrst mode, in the first mode, treatment solution is fed to described o controller (31), and treat solution and leave described first intermediate receptacle (11), and described second intermediate receptacle (12) utilizes treatment solution to fill；And

Control described source flux controller (33), described container selection control (32) and described o controller (31) under the second mode, in this second mode, described second intermediate receptacle (12) is to described o controller (31) conveying treatment solution, and described first intermediate receptacle (11) utilizes the treatment solution from described treatment source of solvent to fill.

Equipment the most according to claim 1, this equipment includes the user interface of the setting value for receiving dialysis fluid flow velocity, wherein, described o controller (31) is configured to according to described dialysis fluid flow velocity by described treatment solution port conveying treatment solution, and described control unit (41) is configured to:

-receive the setting value of described dialysis fluid flow velocity；

-control described o controller (31) so that described treatment solution is according to the described dialysis fluid flow rate corresponding with described treatment solution port (10).

Equipment the most according to claim 2, wherein, described control unit (41) is configured to control described o controller (31) so that described treatment solution is according to described dialysis fluid flow rate based on the described weight signal from described first weight meter (21) and described second weight meter (22).

4. according to the equipment described in any one in claim 2 to 3, wherein, described control unit (41) is configured to control described o controller (31) so that described treatment solution is according to described dialysis fluid flow rate based on the described weight signal from described first weight meter (21) in the case of the described weight signal of described second weight meter (22) not using in the first mode.

5. according to the equipment described in any one in claim 2 to 3, wherein, described control unit (41) is configured to control described o controller (31) so that described treatment solution is according to described dialysis fluid flow rate based on the described weight signal from described second weight meter (22) in the case of the described weight signal of described first weight meter (21) not using in the second mode.

6. according to the equipment described in any one in claims 1 to 3, wherein, described control unit (41) is configured to during treating the course for the treatment of switch repeatedly between described first mode and described second pattern.

7. according to the equipment described in any one in claims 1 to 3, wherein, described control unit (41) is configured to the rate of flow of fluid controlling described source flux controller (33) to provide higher than or to be at most equal to the dialysis fluid flow velocity provided by described o controller (31).

8. according to the equipment described in any one in claims 1 to 3, wherein, described control unit (41) is configured to control described source flux controller (33), described container selection control (32) and described o controller (31) so that provide the continuous stream for the treatment of solution to described treatment solution port when switching between described first mode and described second pattern.

9. according to the equipment described in any one in claims 1 to 3, wherein, described secondary chamber (4) includes that entrance pipe (9) treats fluid to receive, and described treatment solution port (10) is configured to carry treatment solution and/or to described blood circuit conveying treatment solution to the described entrance pipe (8) of described secondary chamber (4).

10. according to the equipment described in any one in claims 1 to 3, wherein, relative to treatment fluid flow direction, described first intermediate receptacle (11) and described second intermediate receptacle (12) and described container selection control (32) are arranged on the upstream of described filter (2).

11. according to the equipment described in any one in claims 1 to 3, wherein, described equipment also includes treating source of solvent (60), and this treatment source of solvent (60) and described first intermediate receptacle (11) and described second intermediate receptacle (12) are in fluid communication with to described first intermediate receptacle or described second intermediate receptacle conveying treatment fluid.

12. according to the equipment described in any one in claims 1 to 3, wherein,

In the first mode, while preventing from treating solution described first intermediate receptacle (11) of inflow, treatment solution can flow into described second intermediate receptacle (12) from described source flux controller (33), and while preventing from treating solution described second intermediate receptacle (12) of outflow, treatment solution can flow to described o controller (31) from described first intermediate receptacle (11), and/or

In the second mode, while preventing from treating solution described second intermediate receptacle (12) of inflow, treatment solution can flow into described first intermediate receptacle (11) from described source flux controller (33), and while preventing from treating solution described first intermediate receptacle (11) of outflow, treatment solution can flow to described o controller (31) from described second intermediate receptacle (12).

13. according to the equipment described in any one in claims 1 to 3, wherein, described equipment also includes that sterilising filter (80), this sterilising filter (80) are positioned between described source flux controller (33) and described first intermediate receptacle (11) and/or the second intermediate receptacle (12).

14. according to the equipment described in any one in claims 1 to 3, wherein, described source flux controller (33) is positioned between described treatment source of solvent (60) and described first intermediate receptacle (11) and described second intermediate receptacle (12) so that be delivered to the treatment solution of described first intermediate receptacle (11) and described second intermediate receptacle (12) through described source flux controller (33) from described treatment source of solvent (60).

15. according to the equipment described in any one in claims 1 to 3, wherein, described container selection control (32) includes valve, this valve is configured with open mode and closed mode, in the on-state, allow to flow through the pipeline that described valve is acted on, in off position under, stop and flow through the pipeline that described valve is acted on.

16. according to the equipment described in any one in claims 1 to 3, wherein, described container selection control (32) includes pump, described pump is configured as during described pump work treating solution by the Pipeline transport at described pump place, stops treatment solution to flow through the described pipeline at described pump place when described air pump inoperative.

17. according to the equipment described in any one in claims 1 to 3, wherein, described container selection control (32) includes banked direction control valves, wherein, in configuring first, described banked direction control valves allows the treatment solution from described treatment source of solvent flow in described first intermediate receptacle and stop described treatment solution to flow in described second intermediate receptacle, and wherein, in configuring second, described banked direction control valves allows the treatment solution from described treatment source of solvent flow in described second intermediate receptacle and stop described treatment solution to flow in described first intermediate receptacle.

18. according to the equipment described in any one in claims 1 to 3, wherein, described first intermediate receptacle rate of discharge controller and described second intermediate receptacle rate of discharge controller include banked direction control valves, wherein, in configuring first, described banked direction control valves allows the treatment solution from described first intermediate receptacle flow to described o controller and stop the treatment solution from described second intermediate receptacle to flow to described o controller, and wherein, in configuring second, described banked direction control valves allows the treatment solution from described second intermediate receptacle flow to described o controller and stop the treatment solution from described first intermediate receptacle to flow to described o controller.

19. according to the equipment described in any one in claims 1 to 3, wherein, described control unit (41) is configured to calculate the amount of the treatment solution being delivered to described o controller (31) from both described first intermediate receptacle (11) and described second intermediate receptacle (12) from received weight signal.

20. according to the equipment described in any one in claims 1 to 3, wherein, described equipment also includes air monitor (70), this air monitor (70) is positioned between described treatment source of solvent (60) and described treatment solution port (10) so that be delivered to the treatment solution of described treatment solution port through described air monitor (70) from described treatment source of solvent.

21. according to the equipment described in any one in claims 1 to 3, and wherein, described equipment also includes the air monitor (70) being positioned between described treatment source of solvent (60) and described source flux controller (33).

22. according to the equipment described in any one in claims 1 to 3, wherein, in the first mode, described control unit (41) be configured to based on from described second weight meter (22) described weight signal do not use in the case of the described weight signal of described first weight meter (21), control described source flux controller (33) so that utilize treatment solution fill described second intermediate receptacle (12).

23. according to the equipment described in any one in claims 1 to 3, wherein, in the second mode, described control unit (41) be configured to based on from described first weight meter (21) described weight signal do not use in the case of the described weight signal of described second weight meter (22), control described source flux controller (33) so that utilize treatment solution fill described first intermediate receptacle (11).

24. according to the equipment described in any one in claims 1 to 3, and wherein, described sterilising filter (80) includes air vent, and this air vent is configured to remove the air become entrained in treatment solution.

25. equipment according to claim 24, described air vent includes hydrophobic membrane.