CN104198745B - The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter - Google Patents

Abstract

The present invention is applicable to medical detecting Instrument technical field, provides the clinical blomelicalbloodgasandelectrolrteanalyzers of a kind of Full automatic multiple parameter, is intended to solve the problem that in prior art, blomelicalbloodgasandelectrolrteanalyzers operation is inconvenient and using state is unstable.This blomelicalbloodgasandelectrolrteanalyzers is used for potassium ion, sodion, chlorion, ionized calcium, pH, lithium ion and TCO in Simultaneously test blood ₂, comprise pack device, liquid separatnig valve, sampling apparatus, electrode sensor assembly, the first peristaltic pump, the second peristaltic pump and reaction cup device; Pack device comprises multiple reagent bag of being arranged side by side and waste fluid bag; Reaction cup device is provided with reaction tank; By arranging multiple reagent bag placed side by side and waste fluid bag in pack device, electrolyte reagent is utilized fully to mix in reaction tank with electrolyte sample, by liquid waste is exported in waste fluid bag automatically, to make the clinical blomelicalbloodgasandelectrolrteanalyzers of this Full automatic multiple parameter easy to operate and simple in whole testing process.

Description

The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter

Technical field

The invention belongs to medical detecting Instrument technical field, particularly relate to the clinical blomelicalbloodgasandelectrolrteanalyzers of a kind of Full automatic multiple parameter.

Background technology

Clinical blomelicalbloodgasandelectrolrteanalyzers is must be obligato in clinical examination, and in clinical, it mainly tests the balance maintaining osmotic pressure in blood of human body, body fluid.Clinical electrolyte analysis instrument is used to the instrument detecting potassium ion, sodion, chlorion, ionized calcium, lithium ion, pH and TCO2 etc. from sample, and sample can be whole blood, serum, blood plasma, urine, dislysate and hydrating fluid.

Potassium, sodium, chlorine, calcium, pH, TCO2 are the electrolytical principal ingredients of blood of human body, and potassium, sodium, calcium are dominant cation, and chlorine, TCO2 are Main Anions.Patient is in operation or the disease generating process such as burn, diarrhoea, acute myocardial infarction, and the concentration of a certain ion or multinomial ion there will be disappearance, causes zwitterion unbalance, entail dangers to life time serious.Clinician needs the blood intermediate ion concentration of monitored patient timely, and which kind of ion this patient that makes a determination accurately, the need of fluid infusion, mends, and mends the amount of ion, has maintained the ionic equilibrium of the blood of this patient.So clinical blomelicalbloodgasandelectrolrteanalyzers is must be obligato in clinical examination.

Because common pack is the design of separate single bottle, or say that 2 kinds or 3 kinds of reagent are integrated into a pack, other reagent still adopt separate single bottle to pack and waste liquid still adopts independent waste liquid bottle splendid attire, like this, due to the limitation of pack design, be integrated in reagent in pack by programmed control automatically from reagent bottle, pack suction operation calibration instrument, and the reagent of separate single bottle packaging all needs user to point out according to instrument or the requirement of supplier, regularly manually carry out sample introduction from sampling needle position, or reagent is poured in sample cup, be positioned over the enterprising sample of advancing of sample injection disc.Like this, user operation is very inconvenient; Simultaneously, due to the instrument reagent can not automatically regularly drawn in separate single bottle packaging carry out correcting, the operation of maintenance aspect, as terminal user does not carry out manual associative operation in time, the using state of instrument can be unstable, goes wrong frequently.

Summary of the invention

The object of the present invention is to provide the clinical blomelicalbloodgasandelectrolrteanalyzers of a kind of Full automatic multiple parameter, be intended to solve the problem that in prior art, clinical blomelicalbloodgasandelectrolrteanalyzers operation is inconvenient and using state is unstable.

The present invention realizes like this, the clinical blomelicalbloodgasandelectrolrteanalyzers of a kind of Full automatic multiple parameter, for the potassium ion in Simultaneously test blood, sodion, chlorion, ionized calcium, pH, lithium ion and TCO2, comprise pack device, liquid separatnig valve, sampling apparatus, electrode sensor assembly, the first peristaltic pump, the second peristaltic pump and reaction cup device; Described pack device comprises and is multiplely arranged side by side to hold different described electrolyte reagent respectively and has the reagent bag of the first connected entrance and be arranged side by side for holding liquid waste and having the waste fluid bag of the second connected entrance with described reagent bag, and is provided with multiple the reagent leadout hole that be communicated with corresponding to described first connected entrance and the waste liquid entrance hole be communicated with described second connected entrance respectively; Described reaction cup device is provided with reaction tank and is positioned at the outage at the bottom of the pond of described reaction tank, and the sample pin comprised in the described reaction tank of insertion and reagent needles; Described in one, reagent leadout hole, described second peristaltic pump are communicated with by flexible pipe successively with the described reagent needles of described reaction cup device, described in other, reagent leadout hole, described liquid separatnig valve, described sampling apparatus, described electrode sensor assembly, described first peristaltic pump are communicated with by flexible pipe successively with the described sample pin of described reaction cup device, and described outage is communicated with successively with described waste liquid entrance hole and described waste fluid bag.

Further, the pack assembly of described reagent bag and described waste fluid bag is provided with in described pack device comprises, described pack assembly comprises the second catheter inserting the first catheter bottom described reagent bag along described first connected entrance and insert along described second connected entrance in described waste fluid bag, each described first catheter is communicated with corresponding described reagent leadout hole, and described second catheter is communicated with described waste liquid entrance hole.

Further, described pack device also comprises and plugs with described pack assembly the adapter be connected, described adapter is provided with arrange and first spliced eye that be interconnected and with described second catheter corresponding arrange and second spliced eye that be interconnected corresponding with described first catheter, each described first spliced eye is interconnected with corresponding described reagent leadout hole, and described second spliced eye and described waste liquid entrance hole are interconnected.

Further, described adapter also comprises and is communicated in transfusion elbow between described first spliced eye and described reagent leadout hole, is communicated in drain elbow between described second spliced eye and described waste liquid entrance hole, and be provided with the storage tank of accommodating described transfusion elbow and described drain elbow, the bottom land of described storage tank comprises and has difference in height and the first plane be parallel to each other and the second plane, and described transfusion elbow and described drain elbow are arranged along described first plane and described second plane respectively.

Further, described reaction tank comprises the first cavity, the second cavity and the 3rd cavity that are interconnected successively, described first cavity is near described Chi Kou, the internal diameter of described first cavity is greater than the internal diameter of described 3rd cavity, and described second cavity is communicated between described first cavity and described 3rd cavity.

Further, described liquid separatnig valve is seven logical liquid separatnig valves, and be provided with and be multiplely positioned at the infusion hole on its valve body and be positioned at the delivery outlet at its top, the corresponding described infusion hole of five described reagent leadout holes and described liquid separatnig valve is by soft pipe connection, and described delivery outlet and described sampling apparatus are interconnected.

Further, described liquid separatnig valve comprises and is arranged in described valve body and has the two-way valve core of liquid-through hole, the optoelectronic switch be installed on described valve body, fixedly mount described optoelectronic switch and the photoelectricity positioning disk being provided with light tank and the drive motor driving described photoelectricity positioning disk to rotate, and described liquid-through hole is connected with described delivery outlet with corresponding described infusion hole.

Further, described sampling apparatus comprise be connected with described delivery outlet connect mouth, by the first driving stepper motor and along the sample injection disc of the multiple circular hole of its circle distribution, be positioned in described circular hole to hold the sample cup of testing sample and to be arranged at and to move up and down with relatively described sample injection disc above described sample injection disc and to be provided with the elevating mechanism of sampling needle, described elevating mechanism is by the second step motor control, sampling needle described in described second step motor control inserts in described sample cup to draw described sample, mouth top is connect to draw corresponding described electrolyte reagent or emptying described in sampling needle described in described second step motor control inserts.

Further, described sampling apparatus also comprises the liquid level optocoupler be communicated with between described sampling needle and described electrode sensor assembly.

Further, described reaction cup device also comprises the first gas circuit pin and the second gas circuit pin, the Valve for compressing tubular liner that the clinical blomelicalbloodgasandelectrolrteanalyzers of described Full automatic multiple parameter also comprises the solenoid valve being communicated in described first gas circuit pin, the pressure transducer being communicated in described second gas circuit pin and is communicated between described outage and described waste liquid entrance hole.

The present invention relative to the technique effect of prior art is: by arranging multiple reagent bag placed side by side and waste fluid bag in pack device, and utilize the reagent leadout hole each described reagent bag of connection and waste liquid entrance hole to be communicated with described waste fluid bag, so that derived by the electrolyte reagent in each reagent bag and the waste liquid of generation is imported described waste fluid bag; Simultaneously, flexible pipe is utilized to be communicated with wherein reagent leadout hole, described second peristaltic pump and described reagent needles described in one successively, so that described electrolyte reagent is imported in described reaction tank, and utilize soft pipe connection other each described reagent leadout hole and described infusion holes, so that being directed into by electrolyte reagent is that liquid separatnig valve is for subsequent use to do, flexible pipe is utilized to be communicated with described delivery outlet, described sampling apparatus, described electrode sensor assembly, described first peristaltic pump and described sample pin successively, so that described electrolyte sample inputed in described reaction tank.Utilize sampling apparatus to be extracted into described electrolyte reagent to record potassium ion, sodion, chlorion, ionized calcium, pH, the lithium ion in blood in described electrode sensor assembly, and utilize described electrolyte reagent and described electrolyte sample in described reaction tank, fully mix the TCO2 recorded in blood.The clinical blomelicalbloodgasandelectrolrteanalyzers of this Full automatic multiple parameter also utilizes flexible pipe to be communicated with described outage, described waste liquid entrance hole and described waste fluid bag successively liquid waste automatically to be exported in described waste fluid bag.

Accompanying drawing explanation

Fig. 1 is a three-dimensional exploded view of the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter that the embodiment of the present invention provides;

Fig. 2 is another three-dimensional exploded view of the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter in Fig. 1;

Fig. 3 is the piping diagram of the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter in Fig. 1;

Fig. 4 is that in Fig. 1, the partial sectional view put packed by reagent;

Fig. 5 is the distribution plan of hollow inserting column in Fig. 4;

Fig. 6 is the structural drawing of reagent bag in Fig. 4;

Fig. 7 is the structural drawing of waste fluid bag in Fig. 4;

Fig. 8 is the stereographic map of adapter in Fig. 4;

Fig. 9 is another stereographic map of adapter in Fig. 4;

Figure 10 is the distribution plan of connecting bend in Fig. 9;

Figure 11 is the partial sectional view of adapter in Fig. 9;

Figure 12 is the cut-open view of reaction cup device in Fig. 1.

Embodiment

In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.

Please refer to Fig. 1 to Fig. 5 and Figure 12, the clinical blomelicalbloodgasandelectrolrteanalyzers of the Full automatic multiple parameter that the embodiment of the present invention provides, for the potassium ion in Simultaneously test blood, sodion, chlorion, ionized calcium, pH, lithium ion and TCO2, comprises pack device 1, liquid separatnig valve 2, sampling apparatus 3, electrode sensor assembly 4, first peristaltic pump 5, second peristaltic pump 6 and reaction cup device 7; Described pack device 1 comprises and is multiplely arranged side by side to hold different described electrolyte reagent respectively and has the reagent bag 11 of the first connected entrance 110 and be arranged side by side for holding liquid waste and having the waste fluid bag 12 of the second connected entrance 120 with described reagent bag 11, and is provided with multiple the reagent leadout hole 150 that be communicated with corresponding to described first connected entrance 110 and the waste liquid entrance hole 151 be communicated with described second connected entrance 120 respectively; Described reaction cup device 7 is provided with reaction tank 710 and is positioned at the outage 712 at the bottom of pond of described reaction tank 710, and the sample pin 730 comprised in the described reaction tank 710 of insertion and reagent needles 732; Described in one, reagent leadout hole 150, described second peristaltic pump 6 are communicated with by flexible pipe 8 successively with the described reagent needles 732 of described reaction cup device 7, described in other, reagent leadout hole 150, described liquid separatnig valve 2, described sampling apparatus 3, described electrode sensor assembly 4, described first peristaltic pump 5 are communicated with by flexible pipe 8 successively with the described sample pin 730 of described reaction cup device 7, and described outage 712 is communicated with successively with described waste liquid entrance hole 151 and described waste fluid bag 12.

In this embodiment, the quantity of described reagent bag 11 can be 2,3,4,5,6,7 and above any number, and the quantity of described reagent leadout hole 150 is corresponding with the quantity of described reagent bag 11.

Preferably, the quantity of described reagent bag 11 is six, hold electrolyte reagent A, electrolyte reagent B, electrolyte reagent C, electrolyte reagent D, electrolyte reagent E and electrolyte reagent F respectively, waste fluid bag 12 is for holding the liquid waste of recovery, each described reagent bag 11 and waste fluid bag 12 placed side by side in accommodating cavity 130, be integrated into a closed pack.The material of described reagent bag 11 and described waste fluid bag 12 is tygon (being called for short PE), nylon, polyethylene terephthalate (being called for short PET) or aluminum foil compound bag, and this aluminum foil compound bag is composited by PET, AL, nylon and PE.

In this embodiment, described electrode sensor assembly 4 adopts tu bular through-flow electrode, comprising potassium, sodium, chlorine, calcium, pH and lithium PVC liquid film ion electrode and 1 pad pasting contrast electrode.The liquid outlet of described electrode sensor assembly 4 is connected to the inlet of described first peristaltic pump 5 by flexible pipe 8.

The liquid outlet of described first peristaltic pump 5 is connected to the sample pin 730 of described reaction cup device 7 by flexible pipe 8.

The liquid outlet of described second peristaltic pump 6 is connected to the reagent needles 732 of described reaction cup device 7 by described flexible pipe 8.

In this embodiment, described distribution valve 2 is for leading to electrolyte reagent A, electrolyte reagent B, electrolyte reagent C, electrolyte reagent D, electrolyte reagent F; Described first peristaltic pump 5 is for providing the power of conveying electrolyte reagent to electrode sensor assembly 4; Reagent sample is extracted in described electrode sensor assembly 4 by described sampling apparatus 3, utilizes described electrode sensor assembly 4 image data and tests potassium ion, sodion, chlorion, calcium ion, pH, lithium.After to be tested, described reagent sample enters in the reaction tank 710 of reaction cup device 7, after described electrolyte reagent E is added reaction tank, carries out hybrid reaction.Preferably, described electrolyte reagent A, electrolyte reagent B, electrolyte reagent C and electrolyte reagent F play calibration function; Meanwhile, electrolyte reagent A is carry out cleanup action to pipeline, the mainly periodic maintenance effect of electrolyte reagent D after each delivery of therapeutic agents sample, and electrolyte reagent F plays the reagent sample reagentia of TCO2 project.

The clinical blomelicalbloodgasandelectrolrteanalyzers of the Full automatic multiple parameter that the embodiment of the present invention provides by arranging multiple reagent bag 11 placed side by side and waste fluid bag 12 in pack device 1, and utilize reagent leadout hole 150 to be communicated with each described reagent bag 11 and waste liquid entrance hole 151 is communicated with described waste fluid bag 12, so that the electrolyte reagent in each reagent bag 11 is derived and the waste liquid of generation is imported described waste fluid bag 12, simultaneously, flexible pipe 8 is utilized to be communicated with wherein reagent leadout hole 150 described in successively, described second peristaltic pump 6 and described reagent needles 732, so that described electrolyte reagent is imported in described reaction tank 710, and utilize flexible pipe 8 to be communicated with other each described reagent leadout hole 150 and described infusion holes 210, so that being directed into by electrolyte reagent is that liquid separatnig valve 2 is for subsequent use to do, flexible pipe 8 is utilized to be communicated with described delivery outlet 212 successively, described sampling apparatus 3, described electrode sensor assembly 4, described first peristaltic pump 5 and described sample pin 730, so that described electrolyte sample is inputed in described electrode sensor assembly 4 and described reaction tank 710.Utilize sampling apparatus 3 to be extracted into described electrolyte reagent to record potassium ion, sodion, chlorion, ionized calcium, pH, the lithium ion in blood in described electrode sensor assembly 4, and utilize described electrolyte reagent and described electrolyte sample in described reaction tank 710, fully mix the TCO2 recorded in blood.The clinical blomelicalbloodgasandelectrolrteanalyzers of this Full automatic multiple parameter also utilizes flexible pipe 8 to be communicated with described outage 712, described waste liquid entrance hole 151 and described waste fluid bag 12 successively liquid waste automatically to be exported in described waste fluid bag 12.

Please refer to Fig. 4 to Fig. 6, further, the pack assembly 10 of described reagent bag 11 and described waste fluid bag 12 is provided with in described pack device 1 comprises, described pack assembly 10 comprises the second catheter 122 inserting the first catheter 112 bottom described reagent bag 11 along described first connected entrance 110 and insert along described second connected entrance 120 in described waste fluid bag 12, each described first catheter 112 is communicated with corresponding described reagent leadout hole 150, and described second catheter 122 is communicated with described waste liquid entrance hole 151.The length of described first catheter 112 is greater than the length of described second catheter 122, and described first catheter 112 and described second catheter 122 are made by PE.Described first catheter 112 inserts bottom described reagent bag 11 so that all derived by the electrolyte reagent in described reagent bag 11 along described first connected entrance 110, described second catheter 122 inserts in described waste fluid bag 12 along described second connected entrance 120, this second catheter 122 need stretch into a bit of distance of described waste fluid bag 12, and without the need to being inserted into bottom it.Described first catheter 112 is connected described flexible pipe 8 (with reference to Fig. 3) with the other end of described second catheter 122, be convenient to other positions described electrolyte reagent being exported to from described reagent bag 11 the clinical blomelicalbloodgasandelectrolrteanalyzers of described Full automatic multiple parameter, or liquid waste be directed in described waste fluid bag 12.Described flexible pipe 8 is utilized to be communicated with described first catheter 112 with described reagent leadout hole 150 to be derived by the electrolyte reagent in each described reagent bag 11, described flexible pipe 8 is utilized to be communicated with described second delivery hole and described waste liquid entrance hole 151, to be poured in described waste fluid bag 12 by described waste gas liquid.

In this embodiment, described first catheter 112 and described first connected entrance 110 are for being tightly connected, prevent electrolyte reagent from flowing out along its junction, described second catheter 122 also for being tightly connected, prevents liquid waste from flowing out along its junction with described second connected entrance 120.

Please refer to Fig. 6, preferably, the top of described waste fluid bag 12 is provided with opening 124, and is pasted with waterproof ventilated membrane 126 in described opening 124 place.The shape of described waterproof ventilated membrane 126 is circular, and pastes double faced adhesive tape in its outer shroud.The material of described waterproof ventilated membrane 126 is poly tetrafluoroethylene (being called for short PTFE) or the eptfe membrane (being called for short ePTFE) of throughput 1000 ~ 10000 ml/min/square centimeter.

Please refer to Fig. 4, further, described pack device 1 also comprises and plugs with described pack assembly 10 adapter 15 be connected, described adapter 15 is provided with arrange and first spliced eye 152 that be interconnected and with described second catheter 122 corresponding arrange and second spliced eye 153 that be interconnected corresponding with described first catheter 112, each described first spliced eye 152 is interconnected with corresponding described reagent leadout hole 150, and described second spliced eye 153 is interconnected with described waste liquid entrance hole 151.Described first spliced eye 152 and described second spliced eye 153 are connected to each described reagent bag 11 and described waste fluid bag 12, also be delivered in the clinical blomelicalbloodgasandelectrolrteanalyzers of described Full automatic multiple parameter thus the electrolyte reagent in each reagent bag 11 is sent in described adapter 15, meanwhile, also the liquid waste produced in clinical for Full automatic multiple parameter blomelicalbloodgasandelectrolrteanalyzers is delivered in waste fluid bag 12 by described adapter 15 and described connectedness.The quantity of described first spliced eye 152 and described reagent leadout hole 150 is six, and be communicated to each described reagent bag 11 and corresponding with described reagent leadout hole 150, namely hold electrolyte reagent A, electrolyte reagent B, electrolyte reagent C, electrolyte reagent D, electrolyte reagent E and the reagent bag 11 of electrolyte reagent F and be communicated with independently the first spliced eye 152 a corresponding independent reagent leadout hole 150 respectively.Described second spliced eye 153 is communicated with described waste fluid bag 12 and described waste liquid entrance hole 151.

Please refer to Fig. 4 and Fig. 5, alternatively, described pack assembly 10 also comprise there is accommodating cavity 130 housing 13, be fixedly installed on described housing 13 and the installing plate 132 with multiple mounting hole 134 and the hollow inserting column 14 be interspersed in described mounting hole 134, described reagent bag 11 and described waste fluid bag 12 are arranged side by side in described accommodating cavity 130, and one end of described hollow inserting column 14 and described first connected entrance 110 are connected with described second connected entrance 120 and the other end is connected with described second spliced eye 153 with described first spliced eye 152.Described mounting hole 134 and the corresponding setting of described hollow inserting column 14, described mounting hole 134 is identical with the number summation of described waste fluid bag 12 with described reagent bag 11 with the number of described hollow inserting column 14, can be 2, 3, 4, 5, 6, 7 and above any number, preferably, the number of described mounting hole 134 and described hollow inserting column 14 is seven, wherein six hollow inserting columns 14 are connected between the first catheter 112 of described reagent bag 11 and described first spliced eye 152, hollow inserting column 14 described in another is connected between the second catheter 122 of described waste fluid bag 12 and described second spliced eye 153, to realize being communicated with of reagent bag 11 and described waste fluid bag 12 and described adapter 15.

In this embodiment, pack device 1 forms a closed reagent bag by multiple reagent bag 11 and waste fluid bag 12 being integrated in described accommodating cavity 130, and utilize adapter 15 to be connected between this closed reagent bag and Electrolytic analyzer, after electrolyte reagent in each reagent bag 11 runs out of after repeatedly testing simultaneously, only described pack assembly 10 need be extracted from adapter 15, and plug new pack assembly 10, replacing can be completed, easy to operate, and in test and Renewal process, human body does not directly contact liquid waste, greatly reduce the possibility of biological pollution.

Please refer to Fig. 4 and Fig. 5, described hollow inserting column 14 comprises the first inserting column 14a being communicated with corresponding described reagent bag 11, second inserting column 14b, 3rd inserting column 14c, 4th inserting column 14d, 5th inserting column 14e and the 6th inserting column 14f and the 7th inserting column 14g being communicated with described waste fluid bag 12, described first inserting column 14a, described second inserting column 14b, described 3rd inserting column 14c and described 4th inserting column 14d is that trapezoidal shape shifts to install, described first inserting column 14a and described 5th inserting column 14e lateral alignment, described 3rd inserting column 14c and described 7th inserting column 14g lateral alignment, described 4th inserting column 14d and described 6th inserting column 14f lateral alignment.The arrangement mode of described mounting hole 134 is identical with the mode of each described hollow inserting column 14, i.e. described first inserting column 14a, described second inserting column 14b, described 3rd inserting column 14c and described 4th inserting column 14d to insert in corresponding mounting hole 134 and respectively in trapezoidal dislocation layout on described housing 13, lay respectively on four angles of same parallelogram in other words, described 5th inserting column 14e, described 6th inserting column 14f and described 7th inserting column 14g lays respectively on leg-of-mutton three angles, and described first inserting column 14a and described 5th inserting column 14e is positioned on same level line, described 3rd inserting column 14c and described 7th inserting column 14g is positioned on same level line, described 4th inserting column 14d and described 6th inserting column 14f is positioned on same level line, above-mentioned three horizontal lines are parallel to each other.

Further, described adapter 15 comprises the first sidepiece 158a and the second sidepiece 158b that are oppositely arranged, be fixed on the outlet end 159 of the end of described first sidepiece 158a and described second sidepiece 158b and be multiplely connected between described first sidepiece 158a and described second sidepiece 158b and extend to the connecting bend 154 of described outlet end 159, each described first spliced eye 152 and described second spliced eye 153 are through described first sidepiece 158a and described second sidepiece 158b, each described reagent leadout hole 150 and described waste liquid entrance hole 151 are arranged at described outlet end 159, corresponding flexible pipe 8 is utilized to be communicated in respectively between each described first spliced eye 152 and corresponding described reagent leadout hole 150 and between described second spliced eye 153 and described waste liquid entrance hole 151 by each described connecting bend 154.Described first sidepiece 158a and described second sidepiece 158b is for be parallel to each other and facing and arrange, and described outlet end 159 is mutually vertical with described second sidepiece 158b with described first sidepiece 158a.Described connecting bend 154 is two-way square elbow, described first spliced eye 152 is inserted with described second spliced eye 153 to be communicated with described second catheter 122 with described first catheter 112 in one end of each described connecting bend 154, the other end is inserted in described reagent leadout hole 150 and described waste liquid entrance hole 151, thus realizes each reagent bag 11 and be communicated with the miscellaneous part of the clinical blomelicalbloodgasandelectrolrteanalyzers of waste fluid bag 12 and Full automatic multiple parameter.

In this embodiment, the material of described connecting bend 154 is PE or polypropylene (being called for short PP).The material of described adapter 15 main body is the silica gel of hardness 30 ~ 80 degree or the Polyurethane Thermoplastic Elastomer rubber (Thermoplasticpolyurethanes is called for short TPU) of hardness 30 ~ 80 degree.

Please refer to Fig. 4, Fig. 7 to Figure 10, preferably, described first spliced eye 152 comprises the first inlet opening 152a corresponding with each described reagent bag 11, second inlet opening 152b, 3rd inlet opening 152c, 4th inlet opening 152d, 5th inlet opening 152e and the 6th inlet opening 152f, described first inlet opening 152a, described second inlet opening 152b, described 3rd inlet opening 152c and described 4th inlet opening 152d is arranged at the side away from described outlet end 159 of described first sidepiece 158a and is dislocatedly distributed in trapezoidal shape, described first inlet opening 152a and described 5th inlet opening 152e lateral alignment, described 3rd inlet opening 152c and described second spliced eye 153 hole lateral alignment, described 4th inlet opening 152d and described 6th inlet opening 152f lateral alignment.The arrangement mode of described first inlet opening 152a, described second inlet opening 152b, described 3rd inlet opening 152c, described 4th inlet opening 152d, described 5th inlet opening 152e, described 6th inlet opening 152f and described second spliced eye 153 and described first inserting column 14a, described second inserting column 14b, described 3rd inserting column 14c, described 4th inserting column 14d, described 5th inserting column 14e, described 6th inserting column 14f are identical with the arrangement mode of described 7th inserting column 14g, and mutually corresponding, with corresponding with each described reagent bag 11 and described waste fluid bag 12.

Preferably, described reagent leadout hole 150 comprises setting in column and is communicated with described first inlet opening 152a by corresponding described connecting bend 154 is corresponding respectively, described second inlet opening 152b, the first fluid hole 150a of described 3rd inlet opening 152c and described 4th inlet opening 152d, second fluid hole 150b, 3rd fluid hole 150c is with the 4th fluid hole 150d and setting in column and be communicated with the 5th fluid hole 150e and the 6th fluid hole 150f of described 5th inlet opening 152e and described 6th inlet opening 152f respectively by corresponding described connecting bend 154, described first fluid hole 150a and described 5th fluid hole 150e lateral alignment, described 3rd fluid hole 150c and described waste liquid entrance hole 151 lateral alignment, described 4th fluid hole 150d and described 6th fluid hole 150f lateral alignment.Each described reagent leadout hole 150 and described waste liquid entrance hole 151 are in two straight line arrangements, wherein said first fluid hole 150a, described second fluid hole 150b, described 3rd fluid hole 150c and described 4th fluid hole 150d is distributed on same straight line successively, described 5th fluid hole 150e, described waste liquid entrance hole 151 and described 6th fluid hole 150f are distributed on another straight line successively, and described first fluid hole 150a and described 5th fluid hole 150e is positioned on same level line, and be parallel to each other with described 3rd fluid hole 150c and described waste liquid entrance hole 151 place straight line and described 4th fluid hole 150d and described 6th fluid hole 150f place straight line.

Please refer to Fig. 7 to Figure 10, further, described switching elbow 154 comprises the drain elbow 156 utilizing corresponding described flexible pipe 8 to be communicated in the transfusion elbow 155 between described first spliced eye 152 and described reagent leadout hole 150 and to be communicated between described second spliced eye 153 and described waste liquid entrance hole 151, and be provided with the storage tank 157 of accommodating described transfusion elbow 155 and described drain elbow 156, the bottom land 1570 of described storage tank 157 comprises and has difference in height and the first plane 1572 and the second plane 1574 be parallel to each other, described transfusion elbow 155 and described drain elbow 156 are arranged along described first plane 1572 and described second plane 1574 respectively.The quantity of described transfusion elbow 155 is identical with the quantity of described reagent bag 11 with described first spliced eye 152.Particularly, described transfusion elbow 155 comprises and utilizes flexible pipe 8 described in be communicated in the first elbow 155a between described first inlet opening 152a and described first fluid hole 150a, flexible pipe 8 described in one is utilized to be communicated in the second elbow 155b between described second inlet opening 152b and described second fluid hole 150b, flexible pipe 8 described in one is utilized to be communicated in triple section arm 155c between described 3rd inlet opening 152c and described 3rd fluid hole 150c, flexible pipe 8 described in one is utilized to be communicated in the 4th elbow 155d between described 4th inlet opening 152d and described 4th fluid hole 150d, utilize flexible pipe 8 described in be communicated in the 5th elbow 155e between described 5th inlet opening 152e and described 5th fluid hole 150e and utilize flexible pipe 8 described in be communicated in the 6th elbow 155f between described 6th inlet opening 152f and described 6th fluid hole 150f, described first elbow 155a, described second elbow 155b, described triple section arm 155c and described 4th elbow 155d is arranged at corresponding described storage tank 157 and is positioned in described first plane 1572, described 5th elbow 155e, described 6th elbow 155f and described drain elbow 156 to be arranged in corresponding described storage tank 157 and to be positioned in described second plane 1574.By the bottom land 1570 of described storage tank 157 being arranged to first plane 1572 and second plane 1574 with difference in height, to play foolproof function.

Described storage tank 157 comprises and communicating respectively and the first guide groove 157a of spaced setting, the second guide groove 157b, the 3rd guide groove 157c and the 4th guide groove 157d with described first fluid hole 150a, described second fluid hole 150b, described 3rd fluid hole 150c and described 4th fluid hole 150d, and described first guide groove 157a, described second guide groove 157b, described 3rd guide groove 157c and described 4th guide groove 157d have along the flow direction of described electrolyte reagent the first plane 1572 and the second plane 1574 be arranged in parallel respectively.Each described connecting bend 154 is contained in corresponding storage tank 157 respectively, particularly, one end of each described reagent leadout hole 150 of connection of described first elbow 155a, described second elbow 155b, described triple section arm 155c and described 4th elbow 155d is placed in described first guide groove 157a, described second guide groove 157b, described 3rd guide groove 157c and described 4th guide groove 157d respectively, and is all positioned in described first plane 1572; The connection described reagent leadout hole 150 of described 5th elbow 155e, described drain elbow 156 and described 6th elbow 155f and one end of described waste liquid entrance hole 151 are placed in described first guide groove 157a, described 3rd guide groove 157c and described 4th guide groove 157d successively, and are all positioned in described second plane 1574.

Please refer to Figure 12, further, described reaction tank 710 comprises the first cavity 7100, second cavity 7102 and the 3rd cavity 7104 that are interconnected successively, described first cavity 7100 is near the pond mouth 7106 of described reaction tank 710, the internal diameter of described first cavity 7100 is greater than the internal diameter of described 3rd cavity 7104, and described second cavity 7102 is communicated between described first cavity 7100 and described 3rd cavity 7104.The xsect of described reaction tank 710 is circular, and described first cavity 7100 is two sections of cavitys that internal diameter size is not identical with described 3rd cavity 7104, and described second cavity 7102 is communicated between described first cavity 7100 and described 3rd cavity 7104.Preferably, the internal diameter of described first cavity 7100 is Φ 20 ~ Φ 30, is highly 5 ~ 20mm, the inwall of described second cavity 7102 is circular conical surface, and the angle of this circular conical surface is 30 ~ 160 degree, is highly 5 ~ 20mm, the internal diameter of described 3rd cavity 7104 is Φ 5 ~ Φ 15, is highly 5 ~ 30mm.By reaction tank 710 being arranged to the first different cavity 7100, second cavity 7102 of internal diameter and the 3rd cavity 7104, also less reaction tank 710 space can be ensured by rational deployment needle tubing 73.The end of described sample pin 730 be angle shape and the mouth of pipe towards the pool wall of described reaction tank 710, the end of described reagent needles 732 is that chamfering is arranged.

Please refer to Figure 12, further, described reaction cup device 7 comprises the reaction cup 71 with described reaction tank 710 and the gland bonnet 72 be fixedly installed in described reaction cup 71, described reaction cup 71 is provided with the accommodating cavity 714 be oppositely arranged with described reaction tank 710, be oppositely arranged at the bottom of the pond of described reaction tank 710 with at the bottom of the chamber of described accommodating cavity 714, described reaction cup device 7 also comprise the stirrer 75 that is arranged at the bottom of described pond and to be arranged at the bottom of described chamber and with the magneton 76 of described stirrer 75 synchronous rotary, described magneton 76 is connected with described stirrer 75 magnetic force.Described magneton 76 is arranged at the bottom of the chamber of described accommodating cavity 714, described stirrer 75 is arranged at the bottom of the pond of described reaction tank 710, and described magneton 76 and the short transverse stacked setting of described stirrer 75 along described reaction tank 710, interactional magnetic force is there is between described magneton 76 and described stirrer 75, described magneton 76 drives described stirrer 75 to rotate at the bottom of the pond of described reaction tank 710, thus the electrolyte reagent be contained in described reaction tank 710 and reagent sample are fully uniformly mixed, to obtain testing result accurately.Preferably, described stirrer 75 is miniature magnetic stirrer 75, and its size is Φ 2 ╳ 4, Φ 2 ╳ 6, Φ 2 ╳ 8, Φ 3 ╳ 4, Φ 3 ╳ 6, Φ 3 ╳ 8, this greatly reduces the size of stirrer 75.The size of described stirrer 75 is less than the internal diameter of described reaction tank 710, reaches maximum to make described stirring rate.

Please refer to Figure 12, preferably, described reaction cup device 7 also comprises and is fixedly installed in described accommodating cavity 714 side and its rotating shaft 770 fixed leg 78 of stretching into the motor 77 in described accommodating cavity 714 and being fixedly installed in described rotating shaft 770, and described magneton 76 is fixedly installed on described fixed leg 78.Magneton 76 in described accommodating cavity 714 is connected with stirrer 75 magnetic force of described reaction tank 710 inside, when described motor 77 starts, the rotating shaft 770 of described motor 77 is rotated and drives described fixed leg 78 to rotate, described stirrer 75 under magneton 76 magneticaction along with the rotation of fixed leg 78 synchronous rotary, play the object of stirring.

Please refer to Figure 12, alternatively, described fixed leg 78 is provided with a pair socket 780, and the opening direction of described socket 780 is at the bottom of described chamber, and the quantity of described magneton 76 is two and symmetrical polarity is installed in described socket 780 on the contrary.By arranging socket 780 on described fixed leg 78, to make described magneton 76 vertically be arranged on described fixed leg 78, magnetic force is strong, stable magnetic field, and adopt two magnetons 76 to be connected with described stirrer 75 magnetic force, in rotary course, there is jumping phenomena to prevent described stirrer 75.

The reaction cup device 7 that the various embodiments described above provide has the advantages such as the high and failure rate is low of high-speed stirred, measured value stability, and overall reaction amount is little, is specially below below reagent sample 150 microlitre and electrolyte reagent 150 microlitre.In high-speed agitating process, such as, without splashing liquid on reaction tank 710 inwall, electrolyte reagent and serum.

Please refer to Fig. 1 to Fig. 3, further, described liquid separatnig valve 2 is seven logical liquid separatnig valves, and be provided with and be multiplely positioned at the infusion hole 210 on its valve body 21 and be positioned at the delivery outlet 212 at its top, the described reagent leadout hole 150 of described adapter 15 is communicated with by flexible pipe 8 to the corresponding described infusion hole 210 of described liquid separatnig valve 2, and described delivery outlet 212 is interconnected with described sampling apparatus 3.

Please refer to Fig. 1 to Fig. 3, further, described liquid separatnig valve 2 comprises and is arranged in described valve body 21 and has the two-way valve core (not shown) of liquid-through hole, the optoelectronic switch (not shown) be installed on described valve body 21, fixedly mount described optoelectronic switch and the photoelectricity positioning disk (not shown) being provided with light tank and the drive motor (not shown) driving described photoelectricity positioning disk to rotate, and described liquid-through hole is connected with described delivery outlet 212 with corresponding described infusion hole 210.The number of described infusion hole 210 is identical with the number of described reagent bag 11, and preferably, the quantity of described infusion hole 210 is six.Two-way valve core described in described infusion hole 210 is connected, and junction O-ring seal (not shown) seals.Described drive motor drives described photoelectricity positioning disk to turn clockwise 60 °, 120 ° and 180 ° and be rotated counterclockwise 60 ° and 120 °, communicate in order respectively with described infusion hole 210 to make the liquid-through hole on described two-way valve core, thus enable electrolyte reagent or air under the effect of described drive motor, transfer in rear class fluid path through described valve body 21 and described spool.Preferably, described drive motor is for being subject to micro-processor controlled stepper motor.

Please refer to Fig. 3, preferably, the infusion hole 210 of described liquid separatnig valve 2 comprises the first infusion hole 210a be connected with described second fluid hole 150b, the second infusion hole 210b be connected with described first fluid hole 150a, the 3rd infusion hole 210c be connected with described 3rd fluid hole 150c, the 4th infusion hole 210d be connected with described 4th fluid hole 150d, the 5th infusion hole 210e be connected with described 6th fluid hole 150f and the air position 210v being in blank state.

Please refer to Fig. 1 to Fig. 3, further, described sampling apparatus 3 comprise be connected with described delivery outlet 212 connect mouth 31, to be driven by the first stepper motor (not shown) and along the sample injection disc 32 of the multiple circular hole 320 of its circle distribution, be positioned in described circular hole 320 to hold the sample cup (not shown) of testing sample and to be arranged at and to move up and down with relatively described sample injection disc 32 above described sample injection disc 32 and to be provided with the elevating mechanism 34 of sampling needle 340, described elevating mechanism 34 is controlled by the second stepper motor (not shown), sampling needle 340 described in described second step motor control inserts in described sample cup to draw described sample, mouth 31 top is connect to draw corresponding described electrolyte reagent or emptying described in sampling needle 340 described in described second step motor control inserts.The described delivery outlet 212 of described liquid separatnig valve 2 is communicated with by described flexible pipe 8.State sample injection disc 32 and be distributed with 36 each circular holes 320 along its even circumferential, wherein 35 is sample position and 1 is cleaning position, and described sample cup is positioned in the circular hole 320 of described sample injection disc 32, and this sample injection disc 32 is by described first driving stepper motor.

In this embodiment, described second stepper motor is straight line penetration type stepper motor 77.

Please refer to Fig. 1 to Fig. 3, described elevating mechanism 34 inserts described sample cup by sampling needle 340 described in described second step motor control, and described first peristaltic pump 5 rotates clockwise, and draws described sample; Described elevating mechanism 34 connects mouth 31 top described in being inserted by sampling needle 340 described in described second step motor control, and described first peristaltic pump 5 rotates clockwise, and draws described electrolyte reagent or emptying.

Please refer to Fig. 1 to Fig. 3, further, described sampling apparatus 3 also comprises the liquid level optocoupler 35 be communicated with between described sampling needle 340 and described electrode sensor assembly 4.Described flexible pipe 8 is communicated with the top of described sampling needle 340, is connected to the inlet of described electrode sensor assembly 4 through described liquid level optocoupler 35.

Please refer to Figure 12, further, described reaction cup device 7 also comprises the first gas circuit pin 734 and the second gas circuit pin 736, the Valve for compressing tubular liner 92 that the clinical blomelicalbloodgasandelectrolrteanalyzers of described Full automatic multiple parameter also comprises the solenoid valve 90 being communicated in described first gas circuit pin 734, the pressure transducer 94 being communicated in described second gas circuit pin 736 and is communicated between described outage 712 and described waste liquid entrance hole 151.Described sample pin 730, described reagent needles 732, described first gas circuit pin 734 and described second gas circuit pin 736 insert in described reaction tank 710 along described gland bonnet 72, reagent sample and electrolyte reagent is communicated to make reaction tank 710, and the gas of described reaction tank 710 is discharged by the first gas circuit pin 734, such as air, described second gas circuit pin 736 connects described pressure transducer 94 with the pressure size in detection reaction pond 710.The end of described sample pin 730 and described reagent needles 732 is all positioned at described 3rd cavity 7104, ensure that described reagent sample enters in reaction tank 710 respectively along described sample pin 730 and described electrolyte reagent along described reagent needles 732 not splash, prevent described reaction tank 710 inwall from adhering to too much reagent sample and electrolyte reagent.Utilize this Valve for compressing tubular liner 92 to control the break-make between described outage 712 and described waste liquid entrance hole 151, be convenient to realize automatically liquid waste being imported in described waste fluid bag 12.

Described sample pin 730, described reagent needles 732, described first gas circuit pin 734 and described second gas circuit pin 736 insert in described reaction tank 710 along described gland bonnet 72, reagent sample and electrolyte reagent is communicated to make reaction tank 710, and discharged the gas of described reaction tank 710 by the first gas circuit pin 734 and described second gas circuit pin 736, such as air.The end of described sample pin 730 and described reagent needles 732 is all positioned at described 3rd cavity 7104, ensure that described reagent sample enters in reaction tank 710 respectively along described sample pin 730 and described electrolyte reagent along described reagent needles 732 not splash, prevent described reaction tank 710 inwall from adhering to too much reagent sample and electrolyte reagent.Preferably, described sample pin 730 and described reagent needles 732 distribute near the center of described gland bonnet 72, and described first gas circuit pin 734 and described second gas circuit pin 736 are distributed in the both sides of described gland bonnet 72.

The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter in various embodiments of the present invention can test potassium, sodium, chlorine, calcium, pH, lithium, TCO2 in blood simultaneously.The mensuration of potassium, sodium, chlorine, calcium, pH, lithium have employed ion-selective electrode method, and the mensuration of TCO2 adopts piezometric method.The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter provided below in conjunction with the embodiment of the present invention illustrates each assay method.

1. ion-selective electrode method (ISE)

Electrolytes determined project is based on ion selective electrode method.Ion-selective electrode is a kind of electrochemical sensor, and it can will treat in solution that the activity change of measured ion converts the change of electrode potential to, and logarithm and the electrode potential of effects of ion activity are linear.

1) ISE (measuring potassium, sodium, chlorine, calcium, pH project)

(1) demarcate

The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter needs regularly to demarcate electrode sensor assembly 4: the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter sucks electrolyte reagent A and electrolyte reagent B automatically successively, measures the current potential E of potassium, sodium, chlorine, calcium, pH _a, E _b, the slope S of potassium, sodium, chlorine, calcium, pH is obtained according to Nernst equation.

$S=\frac{E_B-E_A}{\lg (C_B/C_A)}$ Formula (1)

In formula: C _a, E _arepresent concentration and the current potential of potassium, sodium, chlorine, calcium, pH in electrolyte reagent A; C _b, E _brepresent concentration and the current potential of potassium, sodium, chlorine, calcium, pH in electrolyte reagent B.

(2) measurement of concetration

The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter draws testing sample, measures the response pctential E of potassium, sodium, chlorine, calcium, pH in sample _x, the concentration C X of potassium, sodium, chlorine, calcium, pH in calculation sample:

$C_X=C_A\·{10}^{(E_X-E_A)/S}$ Formula (2)

In formula: C _x, E _xrepresent potassium, sodium, chlorine, calcium, pH concentration and current potential in sample.

2) ISE (lithium project)

(1) Li selectivity factor K _{li, Na}, slope is demarcated

For eliminating the interference of sodion for Li test event, the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter needs regularly to use electrolyte reagent F to Li selectivity factor K _{li, Na}, slope is demarcated:

The clinical blomelicalbloodgasandelectrolrteanalyzers of A, Full automatic multiple parameter sucks electrolyte reagent A, electrolyte reagent B automatically successively, measures the current potential E of lithium _{li, A}, E _{li, B}.This step and 1) in (1) carry out simultaneously.

The clinical blomelicalbloodgasandelectrolrteanalyzers of B, Full automatic multiple parameter sucks electrolyte reagent F, measures the current potential E of the lithium ion in electrolyte reagent F _{li, K}, the concentration Na of sodion ⁺concentration C _{na, K}.

C, successively selection forward K _{li, Na}=0.0080 ~ 0.0150, every 0.0005 gradient, negative sense K _{li, Na}=0.0050 ~ 0.0080, every 0.0005 gradient, substitute into respectively in following formula and calculate different K _{li, Na}the C of value _{li, X}:

$C_{\mathrm{Li},X}=(C_{\mathrm{Li},A}+C_{\mathrm{Na},A}{K}_{\mathrm{Li},\mathrm{Na}})\×{\left(\frac{C_{\mathrm{Li},B}+C_{\mathrm{Na},B}{K}_{\mathrm{Li},\mathrm{Na}}}{C_{\mathrm{Li},A}+C_{\mathrm{Na},A}{K}_{\mathrm{Li},\mathrm{Na}}}\right)}^{\frac{E_{\mathrm{Li},K}-E_{\mathrm{Li},A}}{E_{\mathrm{Li},B}-E_{\mathrm{Li},A}}}-C_{\mathrm{Na},K}\×K_{\mathrm{Li},\mathrm{Na}}$ Formula (3)

In formula: C _{li, A}---the Li in electrolyte reagent A ⁺nominal concentration, mmol/L;

C _{li, B}---the Li in electrolyte reagent B ⁺nominal concentration, mmol/L;

C _{na, A}---the Na in electrolyte reagent A ⁺nominal concentration, mmol/L;

C _{na, B}---the Na in electrolyte reagent B ⁺nominal concentration, mmol/L;

C _{na, K}---the Na in electrolyte reagent F ⁺measured value concentration, mmol/L;

E _{li, A}---the Li in electrolyte reagent A ⁺potential value, mv;

E _{li, B}---the Li in electrolyte reagent B ⁺potential value, mv;

E _{li, K}---the Li in electrolyte reagent F ⁺potential value, mv;

K _{li, Na}---selectivity factor comparison value, the anti-Na of lithium electrode ⁺the leading indicator of interference;

C _{li, X}---the Li of electrolyte reagent F ⁺test comparison value, mmol/L.

D, by different K _{li, Na}the C of value _{li, X}with C _{li, K}compare respectively by following formula, when relative error determines selectivity factor corrected value K ' in ± 3.5% _{li, Na}, the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter is preserved:

Relative error $\mathrm{\δ}=\frac{C_{\mathrm{Li},X}-C_{\mathrm{Li},K}}{C_{\mathrm{Li},K}}\×100\%$ Formula (4)

In formula: C _{li, X}---the Li of electrolyte reagent F ⁺test comparison value, mmol/L;

C _{li, K}---the Li of electrolyte reagent F ⁺nominal value, mmol/L.

E, be calculated as follows the slope S of lithium _li;

$S_{\mathrm{Li}}=\frac{E_{\mathrm{Li},B}-E_{\mathrm{Li},A}}{\lg \left(\frac{C_{\mathrm{Li},B}+C_{\mathrm{Na},B}{K}_{\mathrm{Li},\mathrm{Na}}^{,}}{C_{\mathrm{Li},A}+C_{\mathrm{Na},A}{K}_{\mathrm{Li},\mathrm{Na}}^{,}}\right)}$ Formula (5)

In formula: C _{li, A}---the Li in electrolyte reagent A ⁺nominal concentration, mmol/L;

C _{li, B}---the Li in electrolyte reagent B ⁺nominal concentration, mmol/L;

C _{na, A}---the Na in electrolyte reagent A ⁺nominal concentration, mmol/L;

C _{na, B}---the Na in electrolyte reagent B ⁺nominal concentration, mmol/L;

E _{li, A}---the Li in electrolyte reagent A ⁺potential value, mv;

E _{li, B}---the Li in electrolyte reagent B ⁺potential value, mv;

K ' _{li, Na}---selectivity factor corrected value;

S _li---Li ⁺electrode slope.

(2) measurement of concetration

The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter draws testing sample, measures the potential value of Li in sample, the current potential E of Li+ in calculation sample _{li, sample}, the concentration C of Na+ _{na, sample}, according to the concentration C of the Li+ in formula (6) calculation sample _{li, sample}.This step can be carried out with 1.1 (2) simultaneously.

formula (6)

In formula: C _{li, A}---the Li in electrolyte reagent A ⁺nominal concentration, mmol/L;

C _{na, A}---the Na in electrolyte reagent A ⁺nominal concentration, mmol/L;

C _{na, sample}---the Na in sample ⁺measured value value, mmol/L;

C _{li, sample}---the Li in sample ⁺measured value value, mmol/L;

E _{li, A}---the Li in electrolyte reagent A ⁺potential value, mv;

E _{li, sample}---the Li in sample ⁺potential value, mv;

K ' _{li, Na}---selectivity factor corrected value;

S _li---A, B standard liquid Li ⁺electrode slope;

2, piezometric method (TCO ₂)

Quantitative serum and acidic electrolyte bath reagent E is injected, the HCO in serum in airtight reaction tank 710 ₃-ion and the reaction of acidic electrolyte bath reagent E generate CO ₂gas and discharging, thus cause the pressure in reaction tank 710 to increase.Recorded the variable quantity of pressure by pressure transducer 94, the HCO in serum can be calculated ₃ ^-ion concentration.

(1) demarcate

The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter draws electrolyte reagent C successively, electrolyte reagent E injects reaction tank 710, and after stable, the CO produced tested by pressure transducer 9411 ₂the pressure value P s of gas, according to formula (7) slope calculations S _t.

S _t=P _s/ C _sformula (7)

In formula: P _shCO in-electrolyte reagent C ₃ ^-the force value recorded;

C _shCO in-electrolyte reagent C ₃ ^-concentration.

(2) concentration determination

The clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter successively pipette samples, electrolyte reagent E injects reaction tank 710, and after stable, the CO produced tested by pressure transducer 9411 ₂the pressure value P of gas _x, according to the TCO in formula (8) calculation sample ₂concentration C _x.

C _x=S _tp _xformula (8)

The action sequence of the clinical blomelicalbloodgasandelectrolrteanalyzers of this Full automatic multiple parameter is as follows:

1, ISE calibration:

1) described Valve for compressing tubular liner 92 no power be in open mode, described solenoid valve 90 no power is also in closed condition; By the position of Spool rotating to the first infusion hole 210a of liquid separatnig valve 2; Described first peristaltic pump 5 stops after rotating clockwise to make described sampling needle 340 draw a certain amount of electrolyte reagent A; The valve core reset of liquid separatnig valve 2 is to air position 210v; Described first peristaltic pump 5 continues the electrolyte reagent A rotated clockwise absorption and enters in electrode sensor assembly 4, until liquid level optocoupler 35 detects liquid end, described first peristaltic pump 5 shuts down.After electrode sensor current potential is stable, measure the current potential E of potassium, sodium, chlorine, calcium, pH successively _awith the current potential E of lithium _{li, A}.

2) described Valve for compressing tubular liner 92 no power be in open mode, described solenoid valve 90 no power is also in closed condition; By the position of Spool rotating to the second infusion hole 210b of described liquid separatnig valve 2; Described first peristaltic pump 5 stops after rotating clockwise to make described sampling needle 340 draw a certain amount of electrolyte reagent B; The valve core reset of described liquid separatnig valve 2 is to air position 210v; Described first peristaltic pump 5 continues the electrolyte reagent B rotated clockwise absorption and enters in electrode sensor assembly 4, until liquid level optocoupler 35 detects liquid end, described first peristaltic pump 5 shuts down.After electrode sensor current potential is stable, measure the current potential E of potassium, sodium, chlorine, calcium, pH successively _bwith the current potential E of lithium _{li, B}.The slope S of potassium, sodium, chlorine, calcium, pH is calculated respectively according to formula (1).

2, Li selectivity factor K _{li, Na}slope demarcate:

Described Valve for compressing tubular liner 92 no power is also in open mode, and described solenoid valve 90 no power is also in closed condition; The Spool rotating of described liquid separatnig valve 2 is to the position of the 5th infusion hole 210e; Described first peristaltic pump 5 stops after rotating clockwise and drawing a certain amount of electrolyte reagent F; The valve core reset of described liquid separatnig valve 2 is to air position 210v; Described first peristaltic pump 5 continues the electrolyte reagent F rotated clockwise absorption and enters in electrode sensor assembly 4, until liquid level optocoupler 35 detects liquid end, described first peristaltic pump 5 shuts down.After electrode sensor current potential is stable, measure the current potential E of Li+ in electrolyte reagent F successively _{li, K}, Na ⁺concentration C _{na, K}.Li selectivity factor K is calculated according to formula (3), (4), (5) _{li, Na}and the slope S of Li _li.

3, TCO ₂calibration:

Described solenoid valve 9014 is energized and is in open mode, and described Valve for compressing tubular liner 92 is energized and is in closed condition; The Spool rotating of described liquid separatnig valve 2 is to the position of the 3rd infusion hole 210c; Described first peristaltic pump 5 stops after rotating clockwise to make described sampling needle 340 draw a certain amount of electrolyte reagent C; The valve core reset of described liquid separatnig valve 2 is to air position 210v; Described first peristaltic pump 5 continues to rotate clockwise and enters in the reaction tank 710 of reaction cup device 7 completely by the electrolyte reagent C of absorption; Described second peristaltic pump 6 rotates clockwise and enters in the reaction tank 710 of reaction cup 71 assembly by a certain amount of electrolyte reagent E from described 5th fluid hole 150e; The power-off of described solenoid valve 90 is also in closed condition; Described motor 77 is energized, miniature magnetic stirrer 75 High Rotation Speed, accelerates the chemical reaction of electrolyte reagent C and electrolyte reagent E; The pressure change in reaction tank 710 is monitored by pressure transducer 94; Until pressure is without significant change, preserve corresponding pressure value P _s.S is calculated according to formula (7) _t.

4, ISE test sample:

Described elevating mechanism 34 controls sampling needle 340 and lifts; Described sample injection disc 32 turns to corresponding sample position; Under described elevating mechanism 34 controls the liquid level of the described sample cup of described sampling needle 340 decline insertion; Described first peristaltic pump 5 stops after rotating clockwise and drawing a certain amount of sample; Described solenoid valve 90 is energized and is in open mode, and described Valve for compressing tubular liner 92 is energized and is in closed condition; Described elevating mechanism 34 controls sampling needle 340 and lifts; Described first peristaltic pump 5 continues to rotate clockwise and is entered in electrode sensor assembly 4 by the sample of absorption, until liquid level optocoupler 35 detects liquid end, described first peristaltic pump 5 shuts down.After electrode sensor current potential is stable, measure potassium, sodium, chlorine, calcium, pH successively or/and the current potential E of lithium _x; According to the ISE concentration of formula (2) calculation sample, according to the Li concentration of formula (6) calculation sample.

5, TCO ₂test sample:

Described elevating mechanism 34 controls described sampling needle 340 and lifts; Described sample injection disc 32 turns to corresponding sample position; Under elevating mechanism 34 controls the liquid level of sampling needle 340 decline insertion sample cup; Described first peristaltic pump 5 stops after rotating clockwise and drawing a certain amount of sample; Described solenoid valve 90 is energized and is in open mode, and described Valve for compressing tubular liner 92 is energized and is in closed condition; Described elevating mechanism 34 controls sampling needle 340 and lifts; Described first peristaltic pump 5 continue to rotate clockwise sample is entered completely reaction cup 71 assembly reaction tank 710 in; Described second peristaltic pump 6 rotates clockwise and enters in the reaction tank 710 of reaction cup 71 assembly by a certain amount of electrolyte reagent E; The power-off of described solenoid valve 90 is also in closed condition; Described motor 77 is energized, miniature magnetic stirrer 75 High Rotation Speed, accelerates the chemical reaction of electrolyte reagent C and electrolyte reagent E; The pressure change in reaction tank 710 is monitored by pressure transducer 94; Until pressure is without significant change, preserve corresponding force value E _x.According to the TCO of formula (8) calculation sample ₂concentration.

6, ISE+TCO ₂test sample:

Described elevating mechanism 34 controls sampling needle 340 and lifts; Described sample injection disc 32 turns to corresponding sample position; Under elevating mechanism 34 controls the liquid level of sampling needle 340 decline insertion sample cup; Described first peristaltic pump 5 stops after rotating clockwise and drawing a certain amount of sample; Described solenoid valve 90 is energized and is in open mode, and described Valve for compressing tubular liner 92 is energized and is in closed condition; Elevating mechanism 34 controls sampling needle 340 and lifts; Described first peristaltic pump 5 continues to rotate clockwise and is entered in electrode sensor assembly 4 by the sample of absorption, until liquid level optocoupler 35 detects liquid end, described first peristaltic pump 5 shuts down.After electrode sensor current potential is stable, measure potassium, sodium, chlorine, calcium, pH successively or/and the current potential E of lithium _x; According to the ISE concentration of formula (2) calculation sample, according to the Li concentration of formula (6) calculation sample; Described first peristaltic pump 5 continue to rotate clockwise sample is entered completely reaction cup 71 assembly reaction tank 710 in; Described second peristaltic pump 6 rotates clockwise and enters in the reaction tank 710 of reaction cup 71 assembly by a certain amount of electrolyte reagent E; The power-off of described solenoid valve 90 is also in closed condition; Described motor 77 is energized, miniature magnetic stirrer 75 High Rotation Speed, accelerates the chemical reaction of electrolyte reagent C and electrolyte reagent E; The pressure change in reaction tank 710 is monitored by pressure transducer 94; Until pressure is without significant change, preserve corresponding force value E _x.According to the TCO of formula (8) calculation sample ₂concentration.

7, automatic deproteinized:

When the number of days/number of times testing sample reaches number of days or the number of times of set service intervals, carry out deproteinized.

Described solenoid valve 90 is energized and is in open mode, and described Valve for compressing tubular liner 92 is energized and is in closed condition; Described liquid separatnig valve 2 Spool rotating is to the position of the 4th infusion hole 210d; Described first peristaltic pump 5 stops after rotating clockwise and drawing a certain amount of electrolyte reagent D; The valve core reset of described liquid separatnig valve 2 is to air position 210v; Described first peristaltic pump 5 continues the electrolyte reagent D rotated clockwise absorption and enters in electrode sensor assembly 4, until liquid level optocoupler 357 detects liquid end, described first peristaltic pump 5 shuts down.Soak 5 minutes; Described first peristaltic pump 5 rotates clockwise discharges electrolyte reagent D.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter, it is characterized in that: for the potassium ion in Simultaneously test blood, sodion, chlorion, ionized calcium, pH, lithium ion and TCO2, comprise pack device, liquid separatnig valve, sampling apparatus, electrode sensor assembly, the first peristaltic pump, the second peristaltic pump and reaction cup device, described pack device comprises and is multiplely arranged side by side to hold different described electrolyte reagent respectively and has the reagent bag of the first connected entrance and be arranged side by side for holding liquid waste and having the waste fluid bag of the second connected entrance with described reagent bag, and is provided with multiple the reagent leadout hole that be communicated with corresponding to described first connected entrance and the waste liquid entrance hole be communicated with described second connected entrance respectively, described reaction cup device is provided with reaction tank and is positioned at the outage at the bottom of the pond of described reaction tank, and the sample pin comprised in the described reaction tank of insertion and reagent needles, described in one, reagent leadout hole, described second peristaltic pump are communicated with to import in described reaction tank by described electrolyte reagent with the described reagent needles of described reaction cup device successively by flexible pipe, described in other, reagent leadout hole, described liquid separatnig valve, described sampling apparatus, described electrode sensor assembly, described first peristaltic pump are communicated with by flexible pipe successively with the described sample pin of described reaction cup device, and described outage is communicated with successively with described waste liquid entrance hole and described waste fluid bag, described sampling apparatus extracts electrolyte sample and is sent in described reaction tank by described electrolyte sample through described electrode sensor, and described electrolyte reagent mixes in described reaction tank with described electrolyte sample, described reagent bag is provided with the pack assembly of described waste fluid bag and plug with described pack assembly the adapter be connected in described pack device comprises, described pack assembly comprises the second catheter inserting the first catheter bottom described reagent bag along described first connected entrance and insert along described second connected entrance in described waste fluid bag, each described first catheter is communicated with corresponding described reagent leadout hole, and described second catheter is communicated with described waste liquid entrance hole, described adapter is provided with arrange and first spliced eye that be interconnected corresponding with described first catheter, correspondingly with described second catheter to arrange and the second spliced eye be interconnected, the drain elbow being communicated in the transfusion elbow between described first spliced eye and described reagent leadout hole and being communicated between described second spliced eye and described waste liquid entrance hole, and be provided with the storage tank of accommodating described transfusion elbow and described drain elbow, each described first spliced eye is interconnected with corresponding described reagent leadout hole, described second spliced eye and described waste liquid entrance hole are interconnected, the bottom land that described adapter also comprises described storage tank comprises and has difference in height and the first plane be parallel to each other and the second plane, described transfusion elbow and described drain elbow are arranged along described first plane and described second plane respectively.

2. the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter as claimed in claim 1, it is characterized in that: described reaction tank comprises the first cavity, the second cavity and the 3rd cavity that are interconnected successively, described first cavity is near the Chi Kou of described reaction tank, the internal diameter of described first cavity is greater than the internal diameter of described 3rd cavity, and described second cavity is communicated between described first cavity and described 3rd cavity.

3. the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter as claimed in claim 1, it is characterized in that: described liquid separatnig valve is seven logical liquid separatnig valves, and be provided with and be multiplely positioned at the infusion hole on its valve body and be positioned at the delivery outlet at its top, five described reagent leadout holes pass through soft pipe connection to the corresponding described infusion hole of described liquid separatnig valve, and described delivery outlet and described sampling apparatus are interconnected.

4. the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter as claimed in claim 3, it is characterized in that: described liquid separatnig valve comprises and is arranged in described valve body and has the two-way valve core of liquid-through hole, the optoelectronic switch be installed on described valve body, fixedly mount described optoelectronic switch and the photoelectricity positioning disk being provided with light tank and the drive motor driving described photoelectricity positioning disk to rotate, and described liquid-through hole is connected with described delivery outlet with corresponding described infusion hole.

5. the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter as claimed in claim 1, it is characterized in that: described sampling apparatus comprise be connected with the delivery outlet of described liquid separatnig valve connect mouth, by the first driving stepper motor and along the sample injection disc of the multiple circular hole of its circle distribution, be positioned in described circular hole to hold the sample cup of testing sample and to be arranged at and to move up and down with relatively described sample injection disc above described sample injection disc and to be provided with the elevating mechanism of sampling needle, described elevating mechanism is by the second step motor control, sampling needle described in described second step motor control inserts in described sample cup to draw described sample, mouth top is connect to draw corresponding described electrolyte reagent or emptying described in sampling needle described in described second step motor control inserts.

6. the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter as claimed in claim 5, is characterized in that: described sampling apparatus also comprises the liquid level optocoupler be communicated with between described sampling needle and described electrode sensor assembly.

7. the clinical blomelicalbloodgasandelectrolrteanalyzers of Full automatic multiple parameter as claimed in claim 1, it is characterized in that: described reaction cup device also comprises the first gas circuit pin and the second gas circuit pin, the Valve for compressing tubular liner that the clinical blomelicalbloodgasandelectrolrteanalyzers of described Full automatic multiple parameter also comprises the solenoid valve being communicated in described first gas circuit pin, the pressure transducer being communicated in described second gas circuit pin and is communicated between described outage and described waste liquid entrance hole.