CN104173815B - Treat neurasthenic Chinese medicine composition and preparation method - Google Patents
Treat neurasthenic Chinese medicine composition and preparation method Download PDFInfo
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Abstract
The invention discloses one kind to treat neurasthenic Chinese medicine composition and preparation method, is prepared by following bulk drugs, is parts by weight：Radix bupleuri 10 25；Raddle 8 18；Wilsonii 6 12；Indigo naturalis 25 45；Keel 25 35；Oyster 22 36；Safflower 6 12；Jehol Ligusticum Rhizome 6 15；Fructus gardeniae 6 15；Caulis bambusae in taenian 6 12；Fry Fructus Aurantii 5 15；The number of people 748；Radix glycyrrhizae 36；Rhizoma cyperi 8 16；Snakegourd Fruit 12 18；Yncaria stem with hooks 9 15；The root of herbaceous peony 10 16；Fushen 9 12；Centella 5 12；Polygala 6 15；Sorghum 25 45, the fleece-flower root 39.The excellent results of the present invention are also manifested by：The neurasthenic Chinese medicine composition for the treatment of provided by the invention, is made of pure Chinese herbal medicine, the mutual compatibility of ladies and gentlemen's medicine, complemented one another completely, plays synergy, without any side effects；This prescription has good effect to prevention and treatment insomnia, agitation, dizziness, dreaminess, absent minded, decrease of memory etc..
Description
Technical field
The present invention relates to traditional Chinese medicine field, and neurasthenic Chinese medicine composition and its preparation are treated more particularly to one kind
Method.
Background technology
Neurasthenia be it is a kind of with brain and somatic function it is weak based on neurosis, to be easy to excited and be easy to fatigue as spy
Sign, it is often accompanied by nervous, worried, the physiological dysfunction disease such as emotional symptoms and muscle tone pain, sleep-disorder such as irritability
Shape.Neurasthenia is mainly shown as the imbalance of brain higher nervous activity, is characterized in often feeling mental and is short of physical strength, easily tired
Labor, operating efficiency is low, but exists without organic disease.Can clinically occur it is various be not suitable with symptom, it is such as dizzy, dizzy
Brain is swollen, has a pain in the back, irritable, difficulty falling asleep, dreaming often and waking easily, insomnia forgetfulness, premature ejaculation impotence, can be with minor depressive or Jiao
Consider.
There are some researches show, work, learn it is overstretched act hurriedly in a messy situation, rest and sleep and be irregular, operating pressure is big, and body is in
Sub-health state and emotional instability etc., it is the main reason for causing neurasthenia.Western medical treatment neurasthenia is main at present
Rely on the hypnotic sedative dose for the treatment of such as stable, but these medicines existing defects in terms of security and dependence, it is easy habituation, resistance to
Medicine, side effect is bigger, unsuitable long-term use of.The traditional Chinese medical science thinks that neurasthenia belongs to " being insomnia ", " palpitaition ", " melancholia ", " void
The category such as damage ", " seminal emission ", " impotence ", hindered more by feelings will, visceral dysfunction institute after spiritual overstretched or serious disease prolonged illness
Cause.Stagnation of liver qi is caused if disgruntled not smooth, depression and stagnation of QI, gas lose catharsis；Work with one's mind ponder over, the liver depression impairment of the spleen, insufficiency of the spleen blood are few, the heart is become homeless
Support or the dysfunction of the spleen in transport, source of generating QI and blood deficiency then cause the insufficiency of heart and spleen；Liver depression with the passing of time, change that burn is cloudy, the deficiency of the kidney yin, water is not contained
Wood, liver disorders are supported and then cause the deficiency of liver-yin and kidney-yin；Damage of kidney-essence or excess of sexual intercourse,indulgence in sexual activities injure kidney yang, and essence, which closes the not solid, Yang-function insufficiency of kidneyzang, can also cause kidney
YANG deficiency.Chinese traditional treatment from Overall View, with nourishing liver and kidney, liver soothing and depression relief, invigorating the spleen qi-regulating, replenishing blood for nourishing heart, sedate calm the nerves for
Principle is treated.
The A of publication number CN 102526474（Application number 201210077129.3）Chinese patent literature disclose a kind of use
In for neurasthenic Chinese medicine composition, the Chinese medicine composition is by 35 parts of the Radix Astragali, 32 parts of the fruit of Chinese wolfberry, 28 parts of Poria cocos, Siberian cocklebur
Son 28 parts, 25 parts of barrenwort, 25 parts of polygala, 23 parts of Radix Angelicae Sinensis, 20 parts of jujube, 20 parts of the fruit of Chinese magnoliavine, 18 parts of the bighead atractylodes rhizome, 18 parts of spina date seed,
15 parts of the tuber of dwarf lilyturf, 15 parts of Chinese yam, 13 parts of the banksia rose, 13 parts of cortex albiziae, 10 parts of radix glycyrrhizae, 8 parts of prepared rhizome of rehmannia, 6 parts of ginseng, 5 parts of the root bark of tree peony, the tuber of pinellia
5 parts of compositions.The A of Authorization Notice No. CN 102552671（Application number 201210008029.5）Chinese patent literature disclose one
Kind treats neurasthenic medicament, and it is made of following ingredients are according to weight proportion：Banksia rose 3-10 parts, matrimony vine 2-6 parts, trailing plants
Cottonrose hibiscus wood 10-2 parts, tuber of dwarf lilyturf 3-10 part, Polygonum multiflower knotweed 3-10 parts, radix glycyrrhizae 1-10 parts, Poria cocos 1-3 parts, selfheal 3-10 parts, root of herbaceous peony 1-20
Part, dried orange peel 1-10 parts, polygala 2-6 parts, Radix Astragali 5-10 parts, tuber of pinellia 3-10 parts, Flos Albiziae 1-5 parts, radix bupleuri 2-6 parts.Publication number CN
103721199 A（Application number 201210381921.8）Chinese patent literature disclose one kind and treat neurasthenic Chinese medicinal decoction
Agent, the raw material that it is matched by following weight are made：Ginseng 15-20 parts, tuber of multiflower knotweed 10-20 parts, Radix Astragali 30-40 parts, Radix Angelicae Sinensis 25-35
Part, honey-fried licorice root 7-12 part fushen 25-35 parts, polygala 15-20 parts, spina date seed 30-40 parts, banksia rose 10-15 parts, bighead atractylodes rhizome 8-12 parts.
In a word, western medical treatment neurasthenia relies primarily on the hypnotic sedative dose of symptomatic treatment such as stable, but these medicines are being pacified
Existing defects in terms of full property and dependence, side effect is bigger, easily forms additive, drug resistance, therefore should not take for a long time.
Clinically being used to treating neurasthenic Chinese patent drug at present has cinnabar to repose ball, nourishing blood and tranquilization piece, ZAOREN ANSHEN YE etc..These
Medicine has the effect of certain to neurasthenia, but there is also some problems, and as some drug effects are slow, flavour of a drug are more, inconvenience
Used in preparing, effect is not fairly obvious, Time of Administration length, and curative effect is unstable etc..
The content of the invention
In view of the shortcomings of the prior art, controlling for simple, convenient to take, easy long term usage is prepared it is an object of the invention to provide a kind of
Treat neurasthenic Chinese medicine composition and preparation method thereof.The Chinese medicine composition is curative for effect and has no toxic side effect.
The technical scheme is that:
Neurasthenic Chinese medicine composition is treated, is prepared by following bulk drugs, is parts by weight：Radix bupleuri 10-25, generation
Ochre 8-18, wilsonii 6-12, indigo naturalis 25-45, keel 25-35, oyster 22-36, safflower 6-12, Jehol Ligusticum Rhizome 6-15, fructus gardeniae 6-
15, caulis bambusae in taenian 6-12, fry Fructus Aurantii 5-15, the number of people seven 4-8, radix glycyrrhizae 3-6, rhizoma cyperi 8-16, Snakegourd Fruit 12-18, yncaria stem with hooks 9-15, root of herbaceous peony 10-
16, fushen 9-12, centella 5-12, polygala 6-15, sorghum 25-45, fleece-flower root 3-9.
In preferable scheme, radix bupleuri 15-20, raddle 11-15, wilsonii 8-10, indigo naturalis 30-40, keel 28-32 is male
Oyster 26-32, safflower 8-10, Jehol Ligusticum Rhizome 9-12, fructus gardeniae 9-12, caulis bambusae in taenian 8-10, Fructus Aurantii 8-12, the number of people seven 5-7, radix glycyrrhizae 4-5 are fried, it is fragrant
Attached 10-14, Snakegourd Fruit 14-16, yncaria stem with hooks 10-14, root of herbaceous peony 12-14, fushen 10-11, centella 7-10, polygala 9-12, sorghum 30-
40, fleece-flower root 4-8.
More preferred, radix bupleuri 18, raddle 13, wilsonii 9, indigo naturalis 35, keel 30, oyster 29, safflower 9, Jehol Ligusticum Rhizome 11,
Fructus gardeniae 11, caulis bambusae in taenian 9, Fructus Aurantii 10 is fried, the number of people 76, radix glycyrrhizae 4.5, rhizoma cyperi 12, Snakegourd Fruit 15, yncaria stem with hooks 12, the root of herbaceous peony 13, fushen 10.5,
Centella 8.5, polygala 10.5, sorghum 35, the fleece-flower root 6.
Present invention also offers the preparation method that foregoing Chinese medicine composition is made to pharmaceutically acceptable decoction or pill.
The preparation method of the decoction is：
（1）By indigo naturalis, keel, oyster, crushing, 140-180 mesh sieves are crossed, obtain fine powder；
（2）Raddle, sorghum are ground, with radix bupleuri, wilsonii, Jehol Ligusticum Rhizome, fructus gardeniae, caulis bambusae in taenian, fry Fructus Aurantii, the number of people seven, sweet
Grass, rhizoma cyperi, Snakegourd Fruit, yncaria stem with hooks, the root of herbaceous peony, fushen, centella, polygala and the fleece-flower root are placed in container, add the distillation of 5 times of material quantities
Water, 4-8 hours are soaked, be heated to reflux 2-5 hours, pressure filtration, reclaiming filtrate；Safflower is added in filter residue, then adds 3 times of originals
The distilled water of doses, it is heated to reflux 1-3 hours, rear waste, merging filtrate；
（3）Above-mentioned filtrate is concentrated into the 1/2-1/3 of original volume, adds step（1）Gained fine powder, stirs, sterile
Encapsulation, is produced.
The preparation method of the above-mentioned neurasthenic traditional Chinese herbal decoction for the treatment of, preferable scheme is step（1）Cross 150-170 mesh
Sieve（It is preferred that cross 160 mesh sieves）.
The preparation method of the above-mentioned neurasthenic traditional Chinese herbal decoction for the treatment of, preferable scheme is step（2）Soak time is 5-
7 hours（It is preferred that soak time is 6 hours）.
The preparation method of the pill is：
（1）Various bulk drugs are weighed by formula rate, first cleans, dries, then are ground, 100-140 mesh sieves is crossed, obtains mixing medicine
Powder；
（2）Match somebody with somebody 60 grams of honey by 100 grams of medicinal powder, first honey is placed in pot, tempered with slow fire, waits honey to endure to sticky
Shape, then medicinal powder is mixed, fully mix into ointment thoroughly；
（3）Pill is made by traditional Chinese medical science tradition pill method in above-mentioned gained ointment, produces pill.
The preparation method of the above-mentioned neurasthenic medicine pill for the treatment of, preferable scheme is step（1）Cross 110-130 mesh
Sieve（It is preferred that cross 120 mesh sieves）.
Present invention also offers described Chinese medicine composition to prepare application when treating neurasthenic medicine.
The pharmacology of main Chinese medicine material is as follows used in the present invention：
The number of people seven：Base：For the band root tuber stem of orchid family Herminium plant musk orchid.The property of medicine：《Shanxi Chinese herbal medicine》：" taste
It is sweet, it is warm-natured." function cures mainly：Kidney and spleen invigorating, promoting blood circulation for regulating menstruation, removing toxic substances.Dizzy insomnia is cured mainly, poliosis, loss of appetite, menstruation is not
Adjust, venomous snake bite.
Oyster：Nature and flavor：It is salty, it is slightly cold.Channel tropism：Return liver, courage, kidney channel.Raw oyster preparation method：Clean, dry, pulverize use.
Effect：It is calming the liver；It is transquilization with heavy material；Softening and resolving hard mass；Restrain astringent or styptic treatment for spontaneous sweating.With enriching yin, blood-nourishing, tonifying five zang organs, invigorate blood circulation, fill the work(such as flesh
Effect.Cure mainly dizziness and tinnitus；Insomnia of palpitating with fear；Scrofula goiter and tumor；Abdominal mass lump in the abdomen；Spontaneous sweating；Seminal emission；Uterine bleeding；Under band.
Fructus gardeniae：Nature and flavor：Hardship, tremble with fear.Channel tropism：The thoughts of returning home, liver, lung, stomach.Chemical composition：Gardenin containing flavonoids, pectin,
Tannin, crocin, crocetin, PEARLITOL 25C, nonacosane, cupreol.Glucoside separately containing a variety of tool smelly formaldehyde structures of ring：Cape jasmine
Sub- glucoside, geniposide pool element -1- glycosides, lattice Tegosept P -1- β-D- gentiobiosides and a small amount of shanzhisides.Effect：
Vexed, irascibility hot eyes, headache, damp and hot yellow infantile malnutrition due to digestive disturbances or intestinalparasites, stranguria, bloody flux hematuria, aphthae, sore swollen toxin, strain swelling and pain.Clearly
Heat, purging intense heat, cool blood.Cure mainly：Pyreticosis restlessness of asrhenia type and insomnia, jaundice, gonorrhoea, quenches one's thirst, hot eyes, pharyngalgia, spits blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria,
Pathopyretic ulcer, sprain swelling and pain.
Caulis bambusae in taenian：Base:This product is the drying intermediate layer of the stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or henon bamboo.Property
Shape：This product is the pockets of irregular strand of curling or elongated flake.Nature and flavor：It is sweet, it is slightly cold.Channel tropism：Attach to the lung and stomach meridians.Work(
Effect：Clearing heat and eliminating phlegm, relieve restlessness and prevent vomiting.Cure mainly：Phlegm, dysphoria with smothery sensation vomiting, insomnia of palpitating with fear, middle wind phlegm fan, tongue are held under the arm for phlegm-heat cough courage fire
By force in silence, gastropyretic vomiting, pernicious vomiting, fetal irritability.
Fructus Aurantii：Base：This product is rutaceae bitter orange and its drying immature fruit of variety.Nature and flavor：Bitter,
It is pungent, sour, temperature.Channel tropism：Returns spleen, stomach.Effect：Regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling of row.Cure mainly：For the chest side of body stagnation of the circulation of vital energy.Turgor pain, food
Product is not changed, and stops in phlegm and retained fluid；Gastroptosis, prolapse of the anus, the prolapse of uterus.Fry the preparation method of Fructus Aurantii：Fructus Aurantii removes impurity.Clean, run through,
Shave.Weeded out after drying it is broken fall flesh core.This product is the regular arcuation bar shaped thin slice of wood.Section exocarp sepia to brown,
Middle pericarp yellow-white is to yellowish-brown.Nearly outer rim has 1-2 row point-like grease chambers, and inner side some has a small amount of puce pulp.Stir-baked FRUCTUS AURANTII in bran
Fructus Aurantii piece is taken, method is fried according to bran and fries to discoloration depth.This product is irregular arcuation bar shaped thin slice, and color is deeper, and some has focal spot.
Radix glycyrrhizae（Licorice）：Base：This product is the dry root of glycyrrhizic legume, swollen fruit Radix or glycyrrhiza glabra.Nature and flavor：
It is sweet, put down.Channel tropism：The thoughts of returning home, lung, spleen, stomach.Major function：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, reconcile
All medicines.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate
It is drug toxicity, strong.Licorice：Radix glycyrrhizae is picked into impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, run through section, dry in the air
It is dry.
Rhizoma cyperi：Base：This product is the dry rhizome of sedge nutgrass flatsedge.Nature and flavor：Pungent, slight bitter, micro-sweet, put down.Channel tropism：Return
Liver, spleen, tri-jiao channel.Effect：Promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.Cure mainly：For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, digestion is not
It is good, chest gastral cavity ruffian, cold hernia stomachache, swollen breasts, irregular menstruation, closed dysmenorrhea.
Snakegourd Fruit：Base：This product is the dry mature fruit of cucurbitaceous plant snakegourd or trichosanthes rosthornii Harms.Nature and flavor：Sweet, slight bitter,
It is cold.Channel tropism：Return lung, stomach, large intestine channel.Major function：Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize laxation.It is turbid for cough with lung heat, phlegm
Yellow thick, chest impediment and cardialgia, accumulation of pathogens in chest feeling of fullness, acute mastitis, lung carbuncle, acute appendicitis swelling and pain, constipation.
Yncaria stem with hooks：Base：For madder wort yncaria stem with hooks or Uncaria sinensis and its belong to the buckle branches of various plants together.Chemistry into
Part：Buckle stem branches and leaves containing rhynchophyllin, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali,
Hirsutine, hirsuteine.Pharmacological action：1. sedation, 2. antihypertensive effect.Nature and flavor：It is sweet, it is cool.Channel tropism：Return
Liver, the heart channel of Hang-Shaoyin." The flat liver of heat-clearing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. major function arresting convulsion.Pediatric epilepsy scared Chi Zong is controlled, adult's slight Hypertension is dizzy, dizzy, married woman
Eclampsia.
Fushen：Base：Naturally to entertain pine stump among Polyporaceae plant poria cocos sclerotium（That is " indian bread hostwood "）White portion
Point.Nature and flavor：It is sweet light, put down.Channel tropism：Enter the heart, the spleen channel.Major function：Calming heart, calm the nerves, Li Shui.Palpitation with fear of having a guilty conscience is controlled, forgetful, insomnia,
Frightened epilepsy, difficult urination.Pharmacological action：Sedation.
Polygala：Base：This product is the dry root of milk wort polygala or ovum leaf polygala.Chemical analysis：Root contains saponin, water
Xie Houke gets two kinds of sapogenin crystallizations, presenegenin A and presenegenin B.Closely and from this plant and belong to seneca-snakeroot together
A kind of saponin Roots of Polygala tenuifolia element, i.e. 2 β, 3- β-glycoside of 27- dihydroxy -23- carboxyl oleanolic acids are isolated in root.Separately
Containing polygalytol, 2-Acetamido-2-deoxy-D-glucose, alkaloid tenuidine, fat oil, resin etc..Nature and flavor：It is bitter, pungent, temperature.Return
Through：The thoughts of returning home, kidney, lung channel.Effect：Tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence.Cure mainly：For insomnia and dreamful sleep caused by breakdown of the normal physiological coordination between the heart and the kidney, forgetful
Palpitate with fear, be wandering, expectoration is not well, sore swollen toxin, mastosis.
The fleece-flower root：Base：This product is the dried root of polygonum multiflorum thunb.Nature and flavor：Bitter, sweet, puckery temperature.Channel tropism：Return
Liver, the heart, kidney channel.Pharmacological action：1. effect for reducing blood fat, 2. hypoglycemic effect, 2. antibacterial action.Effect：Removing toxic substances, disappears de-, ease constipation
Defaecation.Cure mainly：For scrofula sore carbuncle, rubella itch, dry constipation of intestines；High fat of blood.
Wilsonii：Base：For the root, rhizome or cauline leaf of studies on plants of Acanthopanax Miq. in Araliaceae wilsonii.Composition：Root contains eleutheroside
A, B, B1, C, D, E, eleutheroside A are daucosterol, and Syringin is syringin；Root also glucoside containing sinapyladehyde, coniferyl aldehyde
Glucoside etc..The property of medicine：《Shaanxi Chinese medicinal herbal》：" pungent, temperature, enter liver, kidney two warp." function cures mainly：QI invigorating, kidney tonifying, calm the nerves, it is living
Blood.Cure mainly insufficiency of the spleen weak, deficiency of vital energy edema, insomnia and dreamful sleep is forgetful, soreness and weakness of waist and knees, children's retardation of walking, obstruction of qi in the chest pain, chronic cough, rheumatism numbness
Bitterly.
Centella：Base：For the drying herb or whole herb with root of dicotyledon Umbelliferae centella.Composition：Containing a variety of
The Triterpenoid of α-botany bar gum alcohol type, wherein have asiaticosid, thankuniside, isothankuniside, madecassoside, glass hot-die
Glycosides, break hot rice glycosides and Brahmic acid etc., and madasiatic acid.The property of medicine：Bitter, acrid, cold.Return liver, spleen, kidney channel.Function cures mainly：
It is clearing heat and detoxicating, it is inducing diuresis and reducing edema.The long-lived medicine of Asians, can beneficial brain refresh oneself.Research show have nourishing, anti-inflammatory, healing of wound,
Diuresis defaecation and calm effect.It is also effective in cure to leprosy, ulcer, there is activation to blood purification and immunity, because it can
Stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, mitigates mental fatigue；Can also hypotensive, control
Treat hepatopathy etc..
Sorghum：Base：For the benevolence of grass family sorghum sorghum.Composition：This product young shoot, fruit contain to hvdroxymandelate
Nitrile glucoside.The property of medicine：It is sweet, puckery, temperature.Function cures mainly：Invigorating the spleen to arrest diarrhea, resolving sputum are calmed the nerves.Splenasthenic diarrhea is cured mainly, cholera, digestion is not
It is good, productive cough due to phlegm-damp, insomnia and dreamful sleep.Safflower：Base:This product dries flower for feverfew safflower.Character:This product is without ovary
Tubular flower.Surface reddish yellow or red.Tube is elongated, and tip 5 splits, and sliver is in slat shape；Flower pesticide aggregates into tubular, yellowish-white
Color；Column cap elongated cylindrical, top differential fork.Matter is soft.Nature and flavor:It is pungent, temperature.Channel tropism:The thoughts of returning home, Liver Channel.Effect:Invigorate blood circulation,
Blood stasis removing analgesic.Cure mainly:For Amenorrhea, dysmenorrhoea, lochia , abdominal lump of mass in abdomen, injury from falling down, sore swell and ache curative.
Jehol Ligusticum Rhizome：Base:This product is the dry rhizome and root of samphire Jehol Ligusticum Rhizome or Ligusticum jeholense.Character:Jehol Ligusticum Rhizome rhizome
In irregular nodular pattern cylinder, slightly distort, there is branch.Surface sepia or burgundy, it is coarse, there are vertical wrinkle, upside residual
There are the root trace and undesirable root of most spot-like projections in the circular stem foot of several depressions, downside.Body is light, and matter is harder, frangibility, section yellow
Or yellow-white, threadiness.Gas giving off a strong fragrance, acrid flavour, hardship, micro- fiber crops.Jehol Ligusticum Rhizome is smaller in river, and rhizome is in irregular lumps or column,
There is the root of most elongate curveds.Nature and flavor:It is pungent, temperature.Channel tropism:Return bladder warp.Effect:Wind-dispelling, cold dispelling, dehumidify, analgesic.Cure mainly:
For anemofrigid cold, mountain peak top pain, rheumatism podomere numbness pain.
Keel：Base：For ancient times mammal as if the fossil of the skeleton of class, rhinoceros class, Hippocampal cortex etc..Chemical analysis：
Predominantly calcium carbonate, calcium phosphate, still iron content, potassium, sodium, chlorine, sulfate radical etc..Nature and flavor：It is sweet puckery, put down.Channel tropism：It is the thoughts of returning home, liver, kidney, big
Intestines pass through.Major function：Tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, myogenic sore.It is demented to control frightened epilepsy, palpitation is forgetful, and insomnia is more
Dream, spontaneous sweating, stranguria with turbid discharge of passing out semen, hematemesis is had blood in stool, and under uterine bleeding band, rush down dysentery prolapse of the anus, ulcer does not close up long.
Indigo naturalis：Base：This product is the leaf or stem of acanthaceous vegetable acanthaceous indigo, polygonaceae plant indigo plant or cruciferae isatis
The processed obtained dried powder of leaf or agglomerate.Character：This product is navy blue powder, and body is light, easily flies upward；Or in irregular more
The agglomerate of permeability, with hand rubbing twist with the fingers smalls.Nature and flavor:It is salty, tremble with fear.Channel tropism：Return liver warp.Effect：It is clearing heat and detoxicating, cool blood, arresting convulsion.
Cure mainly：For febrile virulent maculae, blood-head tells nosebleed, pectoralgia hemoptysis, aphtha, mumps, larynx numbness, pediatric epilepsy scared.
Radix bupleuri：Nature and flavor：It is bitter, cool.Channel tropism：Return liver, gallbladder channel.Effect：It is soothing the liver in inducing diaphoresis, rising Yang.Control fevers and chills alternate, chest
Full hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp prolapse of the anus, irregular menstruation, metroptosis.
Raddle：Base：For the ore of oxide-based mineral bloodstone.Chemical analysis：Master contains di-iron trioxide, wherein iron
70%, oxygen 30%, impure titanium, magnesium, aluminium, silicon and moisture sometimes.Nature and flavor：It is bitter, sweet, flat.Channel tropism：Return liver, stomach, heart born of the same parents warp.Work(
It can cure mainly：Soothing the liver town is inverse, cooling blood and hemostasis.Control gas to vomit inverse, dysphagia and regurgitation, asthma, frightened epilepsy, spit blood, nosebleed epistaxis, intestines wind, hemorrhoid complicated by anal fistula, collapse
Under leakage band.
The root of herbaceous peony：Base:This product is the dry root of ranunculaceae plant Chinese herbaceous peony.Chemical analysis：Root is containing Paeoniflorin, paeonol, Chinese herbaceous peony
Medicine spends glucoside, benzoic acid about 1.07%, volatile oil, fat oil, resin, tannin, sugar, starch, mucilaginous substance, protein, cupreol
And triterpenes.Nature and flavor:Bitter, acid, is slightly cold.Channel tropism:Return liver, the spleen channel.Effect:Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.It is main
Control:For dizziness of having a headache, hypochondriac pain, stomachache, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.
Chinese medicine composition scientific formula provided by the invention, the preparation method of various formulations is simple, the products obtained therefrom side of taking
Just, it is easy to carry.In addition, excellent results of the invention are also manifested by：
1、The Chinese medicine composition for the treatment of provided by the invention, is made of pure Chinese herbal medicine completely, the mutual compatibility of ladies and gentlemen's medicine
Combination, complements one another, and plays synergy, without any side effects；
2、This prescription complies fully with traditional Chinese medicine principle and neurastheniac's body and mind feature, can on the premise of general principle
Different prescriptions, function difference are had according to different crowd.
3、This prescription has very to prevention and treatment insomnia, agitation, dizziness, dreaminess, absent minded, decrease of memory etc.
Good effect.
Embodiment
Technical scheme, but protection domain not limited to this are described in detail with reference to embodiment and experimental example.
Embodiment 1 treats neurasthenic Chinese medicine composition, is prepared by following bulk drugs：Radix bupleuri 10g, raddle
8g, wilsonii 6g, indigo naturalis 25g, keel 25g, oyster 22g, safflower 6g, Jehol Ligusticum Rhizome 6g, fructus gardeniae 6g, caulis bambusae in taenian 6g, fry Fructus Aurantii 5g, people
First seven 4g, radix glycyrrhizae 3g, rhizoma cyperi 8g, Snakegourd Fruit 12g, yncaria stem with hooks 9g, root of herbaceous peony 10g, fushen 9g, centella 5g, polygala 6g, sorghum 25g, what
Tuber of multiflower knotweed 3g.
The preparation method of the above-mentioned neurasthenic traditional Chinese herbal decoction for the treatment of：
（1）By indigo naturalis, keel, oyster, crushing, 140 mesh sieves are crossed, obtain fine powder；
（2）Raddle, sorghum are ground, with radix bupleuri, wilsonii, Jehol Ligusticum Rhizome, fructus gardeniae, caulis bambusae in taenian, fry Fructus Aurantii, the number of people seven, sweet
Grass, rhizoma cyperi, Snakegourd Fruit, yncaria stem with hooks, the root of herbaceous peony, fushen, centella, polygala and the fleece-flower root are placed in container, add the distillation of 5 times of material quantities
Water, soak 4 hours, be heated to reflux 2-5 hours, pressure filtration, reclaiming filtrate；Safflower is added in filter residue, then adds 3 times of raw materials
The distilled water of amount, it is heated to reflux 1-3 hours, rear waste, merging filtrate；
（3）Above-mentioned filtrate is concentrated into the 1/2-1/3 of original volume, adds step（1）Gained fine powder, stirs, sterile
Encapsulation, is produced.
The instructions of taking of decoction of the present invention:One bag every time（About 70m1）, take daily twice（Warm）, treatment in 15 days
Journey.
Embodiment 2 treats neurasthenic Chinese medicine composition, is prepared by following bulk drugs：Radix bupleuri 25, raddle
18, wilsonii 12, indigo naturalis 45, keel 35, oyster 36, safflower 12, Jehol Ligusticum Rhizome 15, fructus gardeniae 15, caulis bambusae in taenian 12, fry Fructus Aurantii 15, the number of people
78, radix glycyrrhizae 6, rhizoma cyperi 16, Snakegourd Fruit 18, yncaria stem with hooks 15, the root of herbaceous peony 16, fushen 12, centella 12, polygala 15, sorghum 45, the fleece-flower root 9.
The preparation method of the above-mentioned neurasthenic traditional Chinese herbal decoction for the treatment of is：
（1）By indigo naturalis, keel, oyster, crushing, 180 mesh sieves are crossed, obtain fine powder；
（2）Raddle, sorghum are ground, with radix bupleuri, wilsonii, Jehol Ligusticum Rhizome, fructus gardeniae, caulis bambusae in taenian, fry Fructus Aurantii, the number of people seven, sweet
Grass, rhizoma cyperi, Snakegourd Fruit, yncaria stem with hooks, the root of herbaceous peony, fushen, centella, polygala and the fleece-flower root are placed in container, add the distillation of 5 times of material quantities
Water, soak 8 hours, be heated to reflux 2-5 hours, pressure filtration, reclaiming filtrate；Safflower is added in filter residue, then adds 3 times of raw materials
The distilled water of amount, it is heated to reflux 1-3 hours, rear waste, merging filtrate；
（3）Above-mentioned filtrate is concentrated into the 1/2-1/3 of original volume, adds step（1）Gained fine powder, stirs, sterile
Encapsulation, is produced.
The instructions of taking of decoction of the present invention:One bag every time（About 70m1）, take daily twice（Warm）, treatment in 15 days
Journey.
Model case：Relative xx, female, teacher, graduates from university, and is had a sleepless night before 5 years, neurolysis, and patient stated it over 5 years
Work, lack experience due to graduating from university, task weight, pressure is big, always wants there is a good performance in unit, therefore, night with
Worked hard after day, engender insomnia, dreaminess, failure of memory.It is diagnosed as neurasthenia.
Take and neurasthenic traditional Chinese herbal decoction is treated obtained by the present embodiment, one bag every time, 2 times a day, 15 days courses for the treatment of.
After taking 15 days, night, which sleeps, pacifies, happy, hale and hearty；One course for the treatment of of following the service, vexed to remove, hypermnesia, patient's self-induction are fullyed recover from an illness
More.
Embodiment 3 treats neurasthenic Chinese medicine composition, is prepared by following bulk drugs：Radix bupleuri 15g, raddle
11g, wilsonii 8g, indigo naturalis 30g, keel 28g, oyster 26g, safflower 8g, Jehol Ligusticum Rhizome 9g, fructus gardeniae 9g, caulis bambusae in taenian 8g, Fructus Aurantii 8g is fried,
The number of people seven 5g, radix glycyrrhizae 4g, rhizoma cyperi 10g, Snakegourd Fruit 14g, yncaria stem with hooks 10g, root of herbaceous peony 12g, fushen 10g, centella 7g, polygala 9g, sorghum
30g, fleece-flower root 4g.
Treating the preparation method of neurasthenic medicine pill is：
（1）Various bulk drugs are weighed by formula rate, first cleans, dries, then are ground, 100 mesh sieves is crossed, obtains mixed powder；
（2）Match somebody with somebody 60 grams of honey by 100 grams of medicinal powder, first honey is placed in pot, tempered with slow fire, waits honey to endure to sticky
Shape, then medicinal powder is mixed, fully mix into ointment thoroughly；
（3）Pill is made by traditional Chinese medical science tradition pill method in above-mentioned gained ointment, produces pill.
The instructions of taking of pill of the present invention:1 ball every time（Drugloading rate about 0.6g）, it is taken three times a day（Warm water delivery service）,
15 days courses for the treatment of.
Embodiment 4 treats neurasthenic Chinese medicine composition, is prepared by following bulk drugs：Radix bupleuri 20g, raddle
15g, wilsonii 10g, indigo naturalis 40g, keel 32g, oyster 32g, safflower 10g, Jehol Ligusticum Rhizome 12g, fructus gardeniae 12g, caulis bambusae in taenian 10g, fry trifoliate orange
Shell 12g, the number of people seven 7g, radix glycyrrhizae 5g, rhizoma cyperi 14g, Snakegourd Fruit 16g, yncaria stem with hooks 14g, root of herbaceous peony 14g, fushen 11g, centella 10g, polygala
12g, sorghum 40g, fleece-flower root 8g.
Treating the preparation method of neurasthenic medicine pill is：
（1）Various bulk drugs are weighed by formula rate, first cleans, dries, then are ground, 140 mesh sieves is crossed, obtains mixed powder；
（2）Match somebody with somebody 60 grams of honey by 100 grams of medicinal powder, first honey is placed in pot, tempered with slow fire, waits honey to endure to sticky
Shape, then medicinal powder is mixed, fully mix into ointment thoroughly；
（3）Pill is made by traditional Chinese medical science tradition pill method in above-mentioned gained ointment, produces pill.
The instructions of taking of pill of the present invention:1 ball every time（Drugloading rate about 0.6g）, it is taken three times a day（Warm water delivery service）,
15 days courses for the treatment of.
Model case：Xxx, high three schoolgirl, 17 years old, readme：Since rising up into high three, it is lasting tired that she often feels like body and mind
It is exhausted, what does and often feels to have a heart but no strength, or even the heart deficiency and power is more insufficient.Start simply to show-a little important and multiple
In miscellaneous activity, such as take an examination, compete, just almost have influence on all aspects later.Learning time slightly length just yawns incessantly, dizzy
Brain is swollen, diverts one's attention, be dim eyesight, drowsiness, sometimes Sunday sleep a whole day, also feel not recover from fatigue very much, it is listless and aching powerless from head to foot.It is usually frequent
Insomnia.The dose of hypnotic is increasing, initially take once, two can work, eat now three, four regardless of with.She
Feel brain reaction worse and worse, decrease of memory.Although her personality generally speaking belongs to introversive, recent easily anxious
Hot-tempered, impulsion, add and do not know it is what reason.At home, have a meal seemingly in order to complete task, need frequently father and mother remind and
Supervise, or even have a meal and also feel very tired.According to the statement and performance of schoolgirl in above-mentioned case, can tentatively it conclude, she suffers from
There is neurasthenia.
Take and neurasthenic medicine pill is treated obtained by the present embodiment, it is taken three times a day using 1 ball every time（Wen Kai
Water delivery service）, 15 days courses for the treatment of.Take 20 days, any of the above symptom has an alleviation, and night sleeps stable, and appetite is normal, and energy fills
It is abundant, normal studying and living can be recovered.2 courses for the treatment of of following the service, patient's recovery from illness, patient is without any discomfort.
Embodiment 5 treats neurasthenic Chinese medicine composition, is prepared by following bulk drugs：Radix bupleuri 18g, raddle
13g, wilsonii 9g, indigo naturalis 35g, keel 30g, oyster 29g, safflower 9g, Jehol Ligusticum Rhizome 11g, fructus gardeniae 11g, caulis bambusae in taenian 9g, fry Fructus Aurantii
10g, the number of people seven 6g, radix glycyrrhizae 4.5g, rhizoma cyperi 12g, Snakegourd Fruit 15g, yncaria stem with hooks 12g, root of herbaceous peony 13g, fushen 10.5g, centella 8.5g, far
Will 10.5g, sorghum 35g, fleece-flower root 6g.
Treating the preparation method of neurasthenic traditional Chinese herbal decoction is：
（1）By indigo naturalis, keel, oyster, crushing, 160 mesh sieves are crossed, obtain fine powder；
（2）Raddle, sorghum are ground, with radix bupleuri, wilsonii, Jehol Ligusticum Rhizome, fructus gardeniae, caulis bambusae in taenian, fry Fructus Aurantii, the number of people seven, sweet
Grass, rhizoma cyperi, Snakegourd Fruit, yncaria stem with hooks, the root of herbaceous peony, fushen, centella, polygala and the fleece-flower root are placed in container, add the distillation of 5 times of material quantity
Water, soak 6 hours, be heated to reflux 2-5 hours, pressure filtration, reclaiming filtrate；Safflower is added in filter residue, then adds material quantity 3
Distilled water again, is heated to reflux 1-3 hours, rear waste, merging filtrate；
（3）Above-mentioned filtrate is concentrated into the 1/2-1/3 of original volume, adds step（1）Gained fine powder, stirs, sterile
Encapsulation, is produced.
The instructions of taking of decoction of the present invention:One bag every time（About 70m1）, take daily twice（Warm）, treatment in 15 days
Journey.
The gained of 1 embodiment of test example 5 treats the clinical practice of neurasthenic Chinese medicine composition aqua：In September, 2010-
In December, 2012,336 neurastheniacs are screened in 4 hospitals.Screening criteria is：The easy excited and mental appearance of patient mental
It is easily tired, worried and mental hygiene symptom of being often in a bad mood.These symptoms can not be attributed to already present physical disease, brain organic disease
Change or certain specific mental illness, lasting nervous or stress may be present before sick.Course of disease at least three moon, symptom are normal
There is fluctuation, with brain postemphasis, mitigate after rest.All patients are not statistically significant at age, the course of disease, symptom etc..It is all
Women 198 in patient, male 138, wherein oldest 65 years old, minimum 18 years old.All patients are randomly divided into two groups,
The products obtained therefrom of embodiment 5 is taken by treatment group and control group, treatment group, and control group takes other medicines（Oryzanol tabletses, Anshen Bunao
The conventional medications such as liquid, zhusha anshen pills）.Application method is:One bag every time（About 70m1）, take daily twice（Warm）, 15 days
One course for the treatment of.Two courses for the treatment of are treated altogether.Curative effect situation criterion:Cure:2 courses for the treatment of of this product are taken, malaise symptoms disappear, essence
Power and muscle power are remarkably reinforced；Effectively：2 courses for the treatment of of this product are taken, malaise symptoms mitigate or partial disappearance, energy and muscle power enhancing；
It is invalid：2 courses for the treatment of of this product are taken, malaise symptoms are unchanged.As a result it is as shown in table 1.
Table 1:Take 18-65 year neurastheniac's treatment results of 5 product of embodiment
Therapeutic effect：Cure 178（84.8%）, effective 27（12.8%）, invalid 5（2.4%）, total effective rate
97.6%.Positive effect is better than control group.
Self-induction symptom and its muscle power spirit change are as shown in table 2 during taking.
Table 2:
Present invention selection keel, the root of herbaceous peony, Jehol Ligusticum Rhizome, sorghum, yncaria stem with hooks etc. carry out compatibility, each traditional Chinese medicinal components interaction compatibility, have
Drug effect is interweaved, mutually promotes and coordinated efficiency, can more effectively treat neurasthenia.Keel, centella, polygala, Fu
God, yncaria stem with hooks tranquillizing the mind by relieving convulsion, QI invigorating nourshing kidney；The root of herbaceous peony, safflower, Jehol Ligusticum Rhizome smooth liver and relieve pain, nourshing blood and promoting blood circulation, tonifying middle-Jiao and Qi；Reason that sorghum is soothing the liver
Gas is eliminating dampness and eliminating phlegm；Wilsonii benefit spleen is cloudy, essence of reinforcing the kidney.Complete square compatibility 5, heart spleen takes into account, mends without stagnant, embellishes but not dry, plays soothing the liver altogether
The effect of analgesic, strengthening the spleen and replenishing qi, antitoxic heart-soothing and sedative.Take 15 days, more than 67% notice, memory are improved；Take 30
My god, more than 91% insomnia and dreamful sleep improves, anxiety, vexed disappearance, spirit and muscle power enhancing, the recovery from illness of some patientss self-induction.Experimental group
In take 30 days, it is efficient up to 97.6%, and control group is only 81.7%.
It should be pointed out that embodiment is the more representational example of the present invention, it is clear that skill of the invention
Art scheme is not limited to above-described embodiment, can also there is many variations.One of ordinary skill in the art, it is clearly public with institute of the invention
Written description open or according to file is undoubted to be obtained, and is considered as this patent scope of the claimed.
Claims (5)
1. the neurasthenic Chinese medicine composition for the treatment of, it is characterised in that pharmaceutically acceptable soup is made in the Chinese medicine composition
Agent or pill, are prepared by following bulk drugs, are parts by weight：Radix bupleuri 15-20, raddle 11-15, wilsonii 8-10 are blue or green
Black pigment used by women in ancient times to paint their eyebrows 30-40, keel 28-32, oyster 26-32, safflower 8-10, Jehol Ligusticum Rhizome 9-12, fructus gardeniae 9-12, caulis bambusae in taenian 8-10, Fructus Aurantii 8-12 is fried,
The number of people seven 5-7, radix glycyrrhizae 4-5, rhizoma cyperi 10-14, Snakegourd Fruit 14-16, yncaria stem with hooks 10-14, root of herbaceous peony 12-14, fushen 10-11, centella 7-
10, polygala 9-12, sorghum 30-40, fleece-flower root 4-8.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that radix bupleuri 18, raddle 13, wilsonii 9, indigo naturalis 35,
Keel 30, oyster 29, safflower 9, Jehol Ligusticum Rhizome 11, fructus gardeniae 11, caulis bambusae in taenian 9, fry Fructus Aurantii 10, the number of people 76, radix glycyrrhizae 4.5, rhizoma cyperi 12, melon
Beach wormwood 15, yncaria stem with hooks 12, the root of herbaceous peony 13, fushen 10.5, centella 8.5, polygala 10.5, sorghum 35, the fleece-flower root 6.
3. the Chinese medicine composition as described in claim 1-2 is any, it is characterised in that the preparation method of decoction is as follows：
（1）By indigo naturalis, keel, oyster, crushing, 160 mesh sieves are crossed, obtain fine powder,
（2）Raddle, sorghum are ground, with radix bupleuri, wilsonii, Jehol Ligusticum Rhizome, fructus gardeniae, caulis bambusae in taenian, stir-fry Fructus Aurantii, the number of people seven, radix glycyrrhizae, perfume (or spice)
Attached, Snakegourd Fruit, yncaria stem with hooks, the root of herbaceous peony, fushen, centella, polygala and the fleece-flower root are placed in container, add the distilled water of 5 times of material quantities, immersion
6 hours, it is heated to reflux 2-5 hours, pressure filtration, reclaiming filtrate, safflower being added in filter residue, then add the steaming of 3 times of material quantities
Distilled water, is heated to reflux 1-3 hours, rear waste, merging filtrate,
（3）Above-mentioned filtrate is concentrated into the 1/2-1/3 of original volume, adds step（1）Gained fine powder, stirs, sterile packaged,
Produce.
4. the Chinese medicine composition as described in claim 1-2 is any, it is characterised in that the preparation method of pill is as follows：
（1）Various bulk drugs are weighed by formula rate, first cleans, dries, then are ground, 120 mesh sieves is crossed, obtains mixed powder,
（2）Match somebody with somebody 60 grams of honey by 100 grams of medicinal powder, first honey is placed in pot, tempered with slow fire, wait honey to endure to thick, then
Medicinal powder is mixed, fully mixes into ointment thoroughly,
（3）Pill is made by traditional Chinese medical science tradition pill method in above-mentioned gained ointment, produces pill.
5. the Chinese medicine composition as described in claim 1-2 is any is preparing the application in treating neurasthenia medicine.
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| CN101732437A (en) * | 2008-11-26 | 2010-06-16 | 黄建国 | Chinese medicinal preparation for treating neurasthenia |
| CN103800888A (en) * | 2014-03-07 | 2014-05-21 | 许传通 | Traditional Chinese medicine composition for treating neurasthenia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101732437A (en) * | 2008-11-26 | 2010-06-16 | 黄建国 | Chinese medicinal preparation for treating neurasthenia |
| CN103800888A (en) * | 2014-03-07 | 2014-05-21 | 许传通 | Traditional Chinese medicine composition for treating neurasthenia |
Non-Patent Citations (3)
| Title |
|---|
| 加味柴胡疏肝散治疗神经症30例;孙海俊;《临床心身疾病杂志》;20040331;第10卷(第1期);53页左栏第1段，第5、6段， * |
| 王翘楚教授从肝论治失眠症;严晓丽;《北京中医药》;20080131;第27卷(第1期);22-23 * |
| 马云枝教授从肝胆论治失眠经验;王维杰;《中国民间疗法》;20091231;第17卷(第12期);第4页左栏第1段，第4-5段，右栏第2、3段 * |
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