CN104173480A - Traditional Chinese medicine composition for treating infantile suppurative tonsillitis - Google Patents
Traditional Chinese medicine composition for treating infantile suppurative tonsillitis Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating infantile suppurative tonsillitis. The composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 10-20 parts of bidens biternata, 5-15 parts of dandelion, 3-7 parts of folium isatidis, 1-3 parts of trollius chinensis bunge, 5-10 parts of platycodon grandiflorum, 1-3 parts of peppermint, 1-3 parts of borneol and 2-8 parts of licorice root. The traditional Chinese medicine composition can be produced into application ointment, avoids using antibiotics, does not need injection or administration, is directly applied to wrists or arches, can be easily accepted by infants, has the advantages of excellent clinical treatment effect, no side effect and long drug acting duration, and is convenient to use.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of the children's's for the treatment of suppurative tonsillitis.
Background technology
Suppurative tonsillitis is usual diseases of childhood, frequently-occurring disease, and it comprises acute follicular tonsillitis and acute lacunar tonsillitis, belongs to the upper respiratory disease of antibacterial due to infecting.Children's's suppurative tonsillitis is treated also certain difficulty, and more early finding to receive treatment effect will be better.The mode of conventional medicament treatment acute tonsillitis is generally to adopt antibiosis anti-inflammatory drug treatment, the shortcoming of this topical therapeutic mode is an antiinflammatory, and can not remove the antibacterial in cryptae tonsillares, once passive protective physical fitness reduces outbreak very easily repeatedly, with the passing of time form chronic lesion.
Suppurative tonsillitis belongs to the traditional Chinese medical science " tonsillitis " category, and its Basic disease cause pathogenesis is exuberant lung-stomach heat.Throat is that department's diet, row are breathed, soniferous organ, the upper oral cavity that connects, and lower logical lung stomach, is again the communications centre of running course of channel.Larynx is, under lung system, to communicate with lung, is the thoroughfare of gas discrepancy; Pharynx, under stomach system, communicates with stomach, is the passage of water paddy.Children's is the body of the young sun of young the moon, gas when susceptible is non-.Clinical take have sore throat, swelling, suppuration is feature.Treatment be take heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, throat pain relieving as main.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition of the children's's for the treatment of suppurative tonsillitis.
A kind of Chinese medicine composition for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
The consumption of composition part of pharmaceutical composition of the present invention is that inventor gets through groping in a large number for a long time to sum up, and each component consumption all has good curative effect at above-mentioned weight portion.
Preferably, a kind of Chinese medicine composition for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae.
Another object of the present invention is to provide a kind of pharmaceutical preparation of Chinese medicine composition of the children's's for the treatment of suppurative tonsillitis.
Chinese medicine composition of the present invention can be made into for oral dosage form.
Chinese medicine composition of the present invention can boil with decocting according to conventional method, makes for oral decoction.
Chinese medicine composition of the present invention adds various conventional adjuvant required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc. is prepared into any conventional oral formulations with conventional method of Chinese medicinal, such as being capsule, tablet, granule etc.
A kind of pharmaceutical preparation for the treatment of the Chinese medicine composition of children's's suppurative tonsillitis provided by the invention, is characterized in that, said preparation is exterior-applied formulation.
The exterior-applied formulation that Chinese medicine composition of the present invention is made is one or more in unguentum, cataplasma, paste, powder, coating unguentum, gel.
Preferably, the exterior-applied formulation that Chinese medicine composition of the present invention is made is coating unguentum.
A kind of Chinese medicine coating unguentum for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, by the Chinese medicine of following weight portion, made: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
Preferably, a kind of Chinese medicine coating unguentum for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, by the Chinese medicine of following weight portion, made: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine coating cream of the children's's for the treatment of suppurative tonsillitis.
A kind of preparation method for the treatment of the Chinese medicine coating cream of children's's suppurative tonsillitis provided by the invention, it is characterized in that, take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part, remove impurity, grind to form fine powder, cross 80 mesh sieves; Then form according to the weight ratio mix of 1:1.0-3.0 with tablet vinegar, obtain coating cream of the present invention.
During use, this can be applied to the position that cream is coated on the easier Transdermal absorption such as wrist or arch of the foot, can further use together with gauze or adhesive tape, prevent pollution clothes simultaneously.
Preferably, a kind of preparation method for the treatment of the middle drug application cream of children's's suppurative tonsillitis provided by the invention, it is characterized in that, take the Chinese medicine of following weight portion: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae, remove impurity, grind to form fine powder, cross 80 mesh sieves; Then form according to the weight ratio mix of 1:1.0-3.0 with tablet vinegar, obtain coating cream of the present invention.
The external application of Chinese medicine is by local application, makes the efficacy of a drug focus of go directly, and effect is concentrated.
Chinese medicine composition of the present invention can be used for the medicine of preparation treatment suppurative tonsillitis.
Chinese medicine composition of the present invention can be used for the medicine of preparation treatment children's suppurative tonsillitis.
The present Research of the related medical material of Chinese medicine of the present invention is as follows:
Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae): for the herb of feverfew bidens pilosa or gold dish silver small cup, sweet, light, flat.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis.For throat pain, acute appendicitis, acute jaundice, vomits and diarrhoea, rheumatic arthritis, malaria, furuncle, venom, treating swelling and pain by traumatic injury.
The effect of Herba Taraxaci is: nature and flavor are sweet, bitter, cold, has heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, antiinflammatory, removing heat from blood, diuresis, function of gallbladder promoting, protects the liver, the several functions such as hypocatharsis, stomach invigorating, anti-cancer.
The curative effect of Folium Isatidis is: heat-clearing and toxic substances removing, and blood cooling and ecchymoses removing, and record the main pyrotoxic dysentery of Folium Isatidis, jaundice, sore throat, erysipelas etc. in < < Compendium of Materia Medica > >.
Flos Trollii: heat-clearing and toxic substances removing.Control sense, tonsillitis, pharyngitis, acute otitis media, acute myringitis, acute conjunctivitis, acute lymphangitis, aphtha, furuncle.
Radix Platycodonis: bitter, pungent, flat.Return lung meridian.Function with cure mainly: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Herba Menthae: pungent, cool.Dispelling wind, heat radiation, ward off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria
Borneolum Syntheticum: acrid in the mouth, hardship, be slightly cold; GUIXIN, liver, lung meridian; Delicate fragrance a surname is loose, has the refreshment of having one's ideas straightened out, the loose poison of heat clearing away, and the effect of improving acuity of vision and removing nebula, cures mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer is hoodwinked key clearly, and sore throat is deaf, and aphtha tooth is swollen, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, harmonizing drug.
Beneficial effect of the present invention:
(1) can avoid antibiotic use,
(2) do not have an injection, do not take medicine, be applied directly to wrist or arch of the foot, be easy to infant and accept,
(3) clinical therapeutic efficacy is excellent, have no side effect,
(4) drug treating time is long, easy to use.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.The present invention's herbal component used all can Cong Ge medium-height grass pharmacy obtain.
Embodiment 1
Take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 15g, Herba Taraxaci 10g, Folium Isatidis 5g, Flos Trollii 2g, Radix Platycodonis 8g, Herba Menthae 2g, Borneolum Syntheticum 2g, Radix Glycyrrhizae 5g, remove impurity, grind to form fine powder, cross 80 mesh sieves, then form according to the weight ratio mix of 1:1.5 with tablet vinegar, obtain coating cream of the present invention.
Embodiment 2
Take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10g, Herba Taraxaci 5g, Folium Isatidis 3g, Flos Trollii 1g, Radix Platycodonis 5g, Herba Menthae 1g, Borneolum Syntheticum 1g, Radix Glycyrrhizae 2g, remove impurity, grinds to form fine powder, crosses 80 mesh sieves, then form according to the weight ratio mix of 1:1.5 with tablet vinegar, obtain coating cream of the present invention.
Embodiment 3
Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20g, Herba Taraxaci 15g, Folium Isatidis 7g, Flos Trollii 3g, Radix Platycodonis 10g, Herba Menthae 3g, Borneolum Syntheticum 3g, Radix Glycyrrhizae 8g, remove impurity, grinds to form fine powder, crosses 80 mesh sieves; Then form according to the weight ratio mix of 1:3.0 with tablet vinegar, obtain coating cream of the present invention.
The irritant experiment of more than 4 coating of embodiment to skin
Experimental technique: select 12 of healthy New Zealand white rabbit, body weight 1.5～2.5kg, is divided into each 6 of normal skin group and skin injury groups, adopts consubstantiality left and right sides self-contrast method, male and female half and half.The test Qian24hDui administration district processing of lose hair or feathers, respectively one of left and right, unhairing scope 3cm * 3cm.Damaged skin group is drawn " well " word at agents area, take and ooze out blood as degree.Every group of left side depilation place is coated with the coating cream 5g left and right (being equivalent to the more than 20 times of human body medication effective dose) of embodiment of the present invention 1-3, and right side is coated with tablet vinegar contrast.Application time 24h, every day 1 time, continuously 7d.Stick after end at every turn, remove test sample and with warm water or nonirritant solvent cleaned medicine-feeding part.Before each coating, examine coating place skin and have or not erythema, edema, after drug withdrawal, continue to observe 3d, by the requirement of new drug toxicity technical specification, carry out skin irritation evaluation.While bark fetching Fu Zuo tissue pathology checking.
Skin irritation is evaluated:
(1) standards of grading: erythema: without erythema 0 minute; Slight erythema (visible reluctantly) 1 minute; The red class of moderate (obviously visible) 2 minutes; Severe erythema 3 minutes; Aubergine erythema forms 4 minutes to slight eschar.Edema: without edema 0 minute; Mild edema (visible reluctantly) 1 minute; Intermediate edema (obviously protuberance) 2 minutes; Severe edema (cutaneous protuberance 1mm, profile is clear) 3 minutes; Serious edema (cutaneous protuberance >lmm also has expansion) 4 minutes.Highest point total value 8 minutes.
(2) skin irritation intensity evaluation standard: 0-0.49 divides nonirritant; 0.50～2.99 minute slight zest; 3.00～5.99 minutes moderate zests; 6.00～8.00 minutes strong and stimulatings.
Result: two groups of rabbit of duration of test are spiritual, sign is good, and appetite activity is normal; Without dead, also have no any untoward reaction; Hematological examination, biochemical investigation are showed no extremely; System becomes celestial and each internal organs histopathology no abnormality seen; Restorative observation has no retardance toxic reaction, detection index normal value with reference to people and rabbit, above result is all within normal range, two groups of more equal nonsignificances (P>0.05), show that rabbit does not produce toxic reaction with the coating cream of embodiment of the present invention 1-3 for a long time.
The allergic experiment of 5 pairs of skins of embodiment
Experimental technique: 50 of Cavia porcelluss, body weight 250-330g, is divided into 30 of the coating cream groups of embodiment of the present invention 1-3, and 10 every group, tablet vinegar matched group 10 only reach 10 of DNFB positive controls, and male and female half and half, shave off skin of back.After 24h, press grouping by medicine 0.5g/cm
2be coated in depilation district, Cavia porcellus left side sensitization, after 3h, repeat coating once, to guarantee medicament contact 6h, within the 7th day and the 14th day, repeat coating sensitization. in last administration 14d, by grouping, medicine is applied to depilation district, Cavia porcellus right side again and excites, after 6h, remove tested material, observe erythema and edema situation, Continuous Observation 3d. marks by skin allergy standard.
Skin irritation is evaluated: with reference to embodiment 4, carry out
Result: experimental result shows all very obvious (erythema 3.23 minutes of positive controls erythema and edema, edema 2.12 minutes), the coating cream group of tablet vinegar matched group and embodiment of the present invention 1-3 skin smooth, without erythema, without edema (being 0 minute), do not show any anaphylaxis.
Embodiment 6 clinical datas
Physical data: select year April in May, 2013 to 2014 in my Out-patient Department and the suppurative tonsillitis infant of being in hospital totally 80 examples, be divided at random treatment group and matched group by medical order.Treatment group 40 examples, male 21 examples wherein, female's 19 examples; 5.08 years old mean age.Matched group 40 examples, male 18 examples wherein, female's 22 examples; 5.82 years old mean age.Two groups of courses of disease are all in 3d.Two groups of infant sexes, age and incidences are learned processing by statistics, and difference no statistical significance (P > 0.05), has comparability.
Diagnostic criteria: with reference to all good fortune Chinese bush cherries of < < practical paidonosology > > diagnostic criteria: heating, pharyngalgia and dysphagia, accompany or do not accompany cough, antiadoncus, there are pus point or pus tongue, two lungs are not heard and rale, and total white blood cells and neutrophilic granulocyte raise, and get rid of lower respiratory infection.
Treatment and care method: treatment group infant is in the coating cream of preparing by each 0.2g/kg coating embodiment of the present invention 1 in two wrists inner sides and two foot arches of the foot, once a day; Matched group adds 10% Glucose Liquid medium-sized vein drop with ceftriaxone, while oral azithromycin 10mg/kg.d, every day 1 time.Two groups of anti symptom treatment are identical.All treat after 7 days for two groups and judge curative effect.
Infant should take in sail, and air keeps certain humidity, to keep sick child's nasopharynx part moistening, keeps room air fresh, reduces pharyngeal stimulation.In acute stage, should eat light polytrophic liquid food easy to digest or half liquid food to infant.Treat that convalescent period eats normal food.During hyperpyrexia, available physical cooling, as forehead cold compress, warm sponge bath, alcohol bath etc.
Criterion of therapeutical effect:
Effective: temperature recovery is normal, pharyngalgia, pharyngeal hyperemia, tonsil purulence thing disappear or substantially disappear.
Take a turn for the better: more first the examining of body temperature decreases, but do not recover normal, symptom, the signs such as pharyngalgia, pharyngeal hyperemia, tonsil purulence thing alleviate.
Invalid: clinical symptoms, sign are without improving or aggravation.
Therapeutic outcome: patient treatment is observe the curative effect after 7 days, treatment group 40 examples, effective 35 examples (87.5%) wherein, 5 examples (12.5%) that take a turn for the better, invalid 0 example (0%), total effective rate 100%; Matched group 40 examples, effective 25 examples (62.5%) wherein, 11 examples (27.5%) that take a turn for the better, invalid 4 examples (10%), total effective rate 90%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.
Claims (8)
1. a Chinese medicine composition for the treatment of children's's suppurative tonsillitis, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
2. the Chinese medicine composition for the treatment of as claimed in claim 1 children's suppurative tonsillitis, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 1 or 2, is characterized in that, the dosage form of this Chinese medicine composition is exterior-applied formulation.
4. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 3, is characterized in that, the exterior-applied formulation of this Chinese medicine composition is one or more in unguentum, cataplasma, paste, powder, coating cream, gel.
5. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 4, is characterized in that, the exterior-applied formulation of this Chinese medicine composition is coating unguentum.
6. a Chinese medicine for the treatment of children's's suppurative tonsillitis applies unguentum, it is characterized in that, this Chinese medicine coating unguentum is made by the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
7. the Chinese medicine of a treatment children's suppurative tonsillitis as claimed in claim 6 applies the preparation method of unguentum, it is characterized in that, take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part, remove impurity, grind to form fine powder, cross 80 mesh sieves; Then form according to the weight ratio mix of 1:1.0-3.0 with tablet vinegar, obtain coating cream of the present invention.
8. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 1 or 2, is characterized in that, the application of this Chinese medicine composition in treatment treatment children's suppurative tonsillitis medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983941A (en) * | 2015-08-10 | 2015-10-21 | 孙霞 | Traditional Chinese medicine for treating child suppurative tonsillitis |
| CN105147971A (en) * | 2015-10-20 | 2015-12-16 | 张军 | Traditional Chinese medicine preparation for treating infantile suppurative tonsillitis |
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| CN103566061A (en) * | 2012-07-26 | 2014-02-12 | 张夏思 | Chinese medicinal composition for treating acute suppurative tonsillitis and preparation thereof |
| CN103585336A (en) * | 2013-11-19 | 2014-02-19 | 钱家美 | Drug composition for treating acute pharyngitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566061A (en) * | 2012-07-26 | 2014-02-12 | 张夏思 | Chinese medicinal composition for treating acute suppurative tonsillitis and preparation thereof |
| CN103585336A (en) * | 2013-11-19 | 2014-02-19 | 钱家美 | Drug composition for treating acute pharyngitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983941A (en) * | 2015-08-10 | 2015-10-21 | 孙霞 | Traditional Chinese medicine for treating child suppurative tonsillitis |
| CN105147971A (en) * | 2015-10-20 | 2015-12-16 | 张军 | Traditional Chinese medicine preparation for treating infantile suppurative tonsillitis |
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Inventor after: Ye Yuling Inventor before: Zhang Qin |
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Effective date of registration: 20161221 Address after: Xinghua City, Jiangsu province 225721 Taizhou City Road No. 31 Nan Zhen Dai health Patentee after: Ye Yuling Address before: Qingdao City, Shandong province 266000 flood ditch cleaning village 106 2 Patentee before: Chen Hong |
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