CN104161802A - Fructus psoraleae and salvia miltiorrhiza tablet - Google Patents

Abstract

The invention provides a fructus psoraleae and salvia miltiorrhiza tablet. The tablet is prepared from the following components by weight: 600g of longspur epimedium, 600g of fructus psoraleae, 300g of eucommia ulmoides, 300g of salvia miltiorrhiza, 35g of calcium carbonate, 20g of soy isoflavone, 20g of vitamin C, 10g of starch and 2.5g of magnesium stearate. The raw materials are extracted, filtered, concentrated and dried, and are pressed into tablets.

Description

Bone fat ginseng sheet

Technical field

The invention belongs to field of health care products, be specifically related to a kind of bone fat ginseng sheet.

Background technology

Along with aged tendency of population, osteoporosis is day by day serious, the over-65s old man osteoporosis that mostly occurs, easily fracture.Osteoporosis is more and more subject to people's attention.Bone strength mainly reflects the integrity of bone density and bone mass.Bone mass comprises bone structure, bone conversion, the accumulation damaging and bone mineralising etc.Bone density refers to the bone mineral content of unit volume, and calcium and phosphorus are the main components of bone mineral nitrogen, and they are more in skeleton deposition, and bone density is larger, and skeleton is more solid.The factor that affects at present human bone mineral density mainly contains height, body weight, hormonal readiness, diet nutritional, life style, physiological situation etc.Think in the past, osteoporotic reason is from calcium deficiency, but that pure is replenished the calcium is invalid.Studies confirm that now it is mainly due to estrogen secretion reduces.The present invention, from increasing the physiological characteristics of bone density and middle-aged and elderly people, be take Chinese medicine as main, is aided with calcium preparation, plant estrogen, vitamin, has invented the bone fat ginseng sheet that strengthens bone substance density improving function.

Summary of the invention

Bone fat ginseng sheet provided by the invention, formula for a product is: Herba Epimedii 600g, Fructus Psoraleae 600g, Cortex Eucommiae 300g, Radix Salviae Miltiorrhizae 300g, calcium carbonate 35g, soybean isoflavone 20g, Catergen 0g, starch 10g, magnesium stearate 2.5g.

Bone fat ginseng sheet provided by the invention, preparation process is as follows:

(1), get Herba Epimedii, Fructus Psoraleae, the Cortex Eucommiae, the Radix Salviae Miltiorrhizae of formula consumption, put in multi-function extractor, the water soaking approximately 30 minutes that adds 6 times of medical materials, decocts and extracts three times, each 1.5 hours, filter (filter material is 80 order nylon cloths), collect filtrate, merging filtrate, gets filter press for supernatant (filter material is filter paper), collect filtrate, put in clean container and preserve.

(2), get above-mentioned filtrate, putting and in vacuum concentrator, being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed), obtains thick paste standby; Vacuum concentration process parameter: vacuum is 0.08Mpa, 80 ℃ of temperature.

(3), get above-mentioned thick paste, with vacuum drying oven be heated to 80 ℃ dry, obtain dry extract, dry extract is ground into 100 order powder with universal mill, obtains dry extract; Vacuum drying process parameter: vacuum is 0.08Mpa, 80 ℃ of temperature.

(4), calcium carbonate fine powder, soybean isoflavone fine powder, vitamin C to mixer are mixed, obtain mixed powder A, mixed powder A, dry extract, starch are put to mixer and mix, cross 80 mesh sieves, obtain mixed powder B.

(5), mixed powder B is put in mixer, add 80% appropriate amount of ethanol, make soft material, then soft material is put in oscillating granulator, by 16-18 eye mesh screen, make wet granular.

(6), wet granular that granulator is got off, put 60 ℃ of temperature in hot air circulation drying oven and dry, then by 18 mesh sieve granulate for dry granule, standby.

(7), in dry granule, add the magnesium stearate of sieving through 100 mesh sieves to make lubricant, mix homogeneously, packs in tablet machine hopper tabletting into.

(8), above-mentioned tablet sieve is removed to fine powder, be sub-packed in bottle quality inspection, packing, warehouse-in.

Bone fat ginseng sheet provided by the invention, from increasing the physiological characteristics of bone density and middle-aged and elderly people, take Chinese medicine as main, is aided with calcium preparation, plant estrogen, vitamin, has the bone density of enhancing effect.

Accompanying drawing explanation

Fig. 1 is bone fat ginseng sheet preparation technology flow chart

The specific embodiment

Embodiment, takes respectively Herba Epimedii 600g, Fructus Psoraleae 600g, Cortex Eucommiae 300g, Radix Salviae Miltiorrhizae 300g, calcium carbonate 35g, soybean isoflavone 20g, Catergen 0g, starch 10g, magnesium stearate 2.5g, above-mentioned raw materials, after extracting, filter, concentrate, being dried, is pressed into 1000, every heavy 0.5g.

Adopt 50 of female rats, body weight 240-300g is as experimental animal.Rat is fed after three days with normal feedstuff adaptability, according to body weight, is divided at random following five groups: sham operated rats, 3% pentobarbital sodium intraperitoneal anesthesia, under strict sterile working, gets the fat dorsal part two incision of lumbar vertebra and enters abdominal cavity, extract after a little mesostenium, layer-by-layer suture otch carefully stops blooding.Model control group, anesthesia is the same, in strict sterile working, gets the other dorsal part two incision of lumbar vertebra, enters abdominal cavity dorsal part, and after complete excision bilateral ovaries, layer-by-layer suture otch carefully stops blooding.Three experimental grouies of bone fat ginseng sheet, 250mg/kg group, 500mg/kg group, 1000mg/kg group (be equivalent to respectively human intaking amount 50mg/kg 5,10,20 times), in strict accordance with aforesaid operations program, row bilateral oophorectomy.Every group 10, postoperative three days, three experimental grouies were joined sheet content aqueous solution gavage with the bone fat of corresponding measurement, and sham operated rats and model control group are with distilled water gavage.Experimental period 12 weeks, weighs weekly.Test last femoral artery sacrificed by exsanguination animal, take out right side femur, in 105 ℃ of baking ovens, bake constant weight, weighs and estimates heavily.Adopt DPX-L dual energy X-ray absorptiometry instrument to measure fl bone density (g/cm ²), adopt the right femur calcium content of atomic absorption spectroscopy determination.

Experimental data statistics: use PEMS3.0 statistical package, the component differences of each index is done to variance analysis.

The results are shown in Table 1, table 2.

The impact that table 1 bone fat ginseng sheet weighs rat body weight, bone

From table 1, there was no significant difference (p > 0.05) between the body weight of three experimental grouies of bone fat ginseng sheet and model control group; The right femur of three experimental grouies of model control group and tested material is heavy to be compared without significant difference (p > 0.05) with sham operated rats

The impact of table 2 fat ginseng sheet on rat bone density and calcium content of bone

From table 2, model control group fl bone density is significantly lower than sham operated rats (p < 0.01); The bone density of bone fat ginseng sheet experimental group is significantly higher than model control group (p < 0.05).Right femur calcium content and the model control group of model control group and bone fat ginseng sheet experimental group relatively have reduction trend, but nonsignificance (p > 0.05).

Conclusion: bone fat ginseng sheet has the function that increases bone density.

Claims (2)

1. a bone fat ginseng sheet, is characterized in that: formula for a product is: Herba Epimedii 600g, Fructus Psoraleae 600g, Cortex Eucommiae 300g, Radix Salviae Miltiorrhizae 300g, calcium carbonate 35g, soybean isoflavone 20g, Catergen 0g, starch 10g, magnesium stearate 2.5g.

2. according to the bone fat ginseng sheet described in right 1, it is characterized in that: preparation process is as follows:

(1), get Herba Epimedii, Fructus Psoraleae, the Cortex Eucommiae, the Radix Salviae Miltiorrhizae of formula consumption, put in multi-function extractor, the water soaking approximately 30 minutes that adds 6 times of medical materials, decocts and extracts three times, each 1.5 hours, filter (filter material is 80 order nylon cloths), collect filtrate, merging filtrate, gets filter press for supernatant (filter material is filter paper), collect filtrate, put in clean container and preserve.

(2), get above-mentioned filtrate, putting and in vacuum concentrator, being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed), obtains thick paste standby; Vacuum concentration process parameter: vacuum is 0.08Mpa, 80 ℃ of temperature.

(3), get above-mentioned thick paste, with vacuum drying oven be heated to 80 ℃ dry, obtain dry extract, dry extract is ground into 100 order powder with universal mill, obtains dry extract; Vacuum drying process parameter: vacuum is 0.08Mpa, 80 ℃ of temperature.

(4), calcium carbonate fine powder, soybean isoflavone fine powder, vitamin C to mixer are mixed, obtain mixed powder A, mixed powder A, dry extract, starch are put to mixer and mix, cross 80 mesh sieves, obtain mixed powder B.

(5), mixed powder B is put in mixer, add 80% appropriate amount of ethanol, make soft material, then soft material is put in oscillating granulator, by 16-18 eye mesh screen, make wet granular.

(6), wet granular that granulator is got off, put 60 ℃ of temperature in hot air circulation drying oven and dry, then by 18 mesh sieve granulate for dry granule, standby.

(7), in dry granule, add the magnesium stearate of sieving through 100 mesh sieves to make lubricant, mix homogeneously, packs in tablet machine hopper tabletting into.

(8), above-mentioned tablet sieve is removed to fine powder, be sub-packed in bottle quality inspection, packing, warehouse-in.