CN104161738A - Cefradine tablet for treating infection caused by sensitive bacteria and preparation method thereof - Google Patents
Cefradine tablet for treating infection caused by sensitive bacteria and preparation method thereof Download PDFInfo
- Publication number
- CN104161738A CN104161738A CN201410317953.0A CN201410317953A CN104161738A CN 104161738 A CN104161738 A CN 104161738A CN 201410317953 A CN201410317953 A CN 201410317953A CN 104161738 A CN104161738 A CN 104161738A
- Authority
- CN
- China
- Prior art keywords
- cefradine
- magnesium stearate
- infection caused
- tablet
- sensitive bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a cefradine tablet for treating infection caused by sensitive bacteria, which comprises the main components of cefradine of 250g and auxiliary materials of: 30-80g of microcrystalline cellulose, 10-30g of lactose, 10-20g of carboxymethyl starch sodium, 2-8g of magnesium stearate, 1-5g of silicon dioxide, 05-2g of potassium hydrogen tartrate, 2-5g of hydroxypropyl methylcellulose, 2-8g of polyacrylic resin IV, 1-5g of magnesium stearate, 1-5g of titanium dioxide, 1-5g of talcum powder, 0.01-0.1g of lemon yellow and 100-150g of 95% ethanol. The cephalosporin-cephradine tablets for treating the infection caused by the sensitive bacteria have obvious curative effect on the infection caused by the sensitive bacteria, have strong pertinence, obvious drug effect, short treatment time and definite and obvious curative effect, and can enrich the market drug varieties so as to better meet and guarantee the drug requirements of people. The cefradine tablet of the invention has simple production process, convenient manufacture and low price.
Description
Technical field
The present invention relates to a kind of cefradine sheet, particularly a kind of cefradine sheet and preparation method infecting due to sensitive organism for the treatment of.
Background technology
In life, often run into, as sprain, damage, the situation such as common fracture, when there is above-mentioned situation, its cardinal symptom is that local hemorrhage causes swelling, part open wound also can cause wound inflammation infection, or the acute pharyngitis due to sensitive organism, tonsillitis, otitis media, bronchitis, pneumonia, respiratory tract infection, urogenital infections, skin soft-tissue infection etc.This para-infectious medicine for the treatment of is very many at present, and in existing cefradine sheet, what have cures the symptoms, not the disease, the expensive composition of some uses causes drug price high, some processing technology very complicateds, existing cefradine sheet curative effect is too broad, cause the composition of formula various in a jumble, specific aim to the real cause of disease is low, and uncertain therapeutic efficacy is cut, and takes effect slow, these cefradine sheets have certain curative effect to slight infection, but when running into the heavier situation of the state of an illness, its effect just and not obvious, takes effect slow, and therapeutic effect is poor.
Therefore, how to realize a kind of drug effect obvious, with strong points, instant effect, determined curative effect and significantly, easy to make, the cefradine sheet infecting due to cheap treatment sensitive organism is technical problem urgently to be resolved hurrily in the industry.
Summary of the invention
Main purpose of the present invention is to provide a kind of cefradine sheet and preparation method infecting due to sensitive organism for the treatment of, and is intended to realize a kind of drug effect obvious, with strong points, instant effect, determined curative effect and significantly, easy to make, the cefradine sheet infecting due to cheap treatment sensitive organism.
The present invention proposes a kind of cefradine sheet infecting due to sensitive organism for the treatment of, the main component of this formula is cefradine 250g, and adjuvant is: microcrystalline Cellulose 30-80g, lactose 10-30g, carboxymethylstach sodium 10-20g, magnesium stearate 2-8g, silica 1-5g, potassium hydrogen tartrate 05-2g, hypromellose 2-5g, polyacrylate resin 2-8g, magnesium stearate 1-5g, titanium dioxide 1-5g, Pulvis Talci 1-5g, lemon yellow 0.01-0.1g, 95% ethanol 100-150g.
The present invention proposes a kind of preparation method for the treatment of the cefradine sheet infecting due to sensitive organism, comprises the following steps:
(1) cefradine is pulverized, potassium hydrogen tartrate, microcrystalline Cellulose, lactose, carboxymethylstach sodium, magnesium stearate, silicon dioxide are sieved respectively;
(2) in cefradine, microcrystalline Cellulose, lactose, carboxymethylstach sodium (inside adding), potassium hydrogen tartrate, add 8% hypromellose to carry out wet granulation, rear dry granulate;
(3) dry granule and additional mixing of materials are even, and described additional material is carboxymethylstach sodium, magnesium stearate, silicon dioxide;
(4) tabletting;
(5) polyacrylate resin of getting recipe quantity, in stainless steel cask, to dissolving completely, soaks more than 6 hours by 95% soak with ethanol, after adding titanium dioxide, Pulvis Talci, magnesium stearate, lemon yellow to stir, sieve, the ethanol that adds again remaining recipe quantity, stirs, coating and get final product.
Cephalosporin-cefradine the sheet infecting due to treatment sensitive organism of the present invention, for sensitive organism, infect and there is significant curative effect, with strong points, drug effect is obvious, treatment time is short, determined curative effect and significantly, the cefradine sheet infecting due to treatment sensitive organism of the present invention can enrich market medicine variety, to meet and to ensure better people's medication demand.And cefradine sheet production process of the present invention is simple, easy to make, cheap.It is obvious that the present invention has really realized a kind of drug effect, with strong points, instant effect, and determined curative effect and significantly, easy to make, the cephalosporin-cefradine sheet infecting due to cheap treatment sensitive organism.
The specific embodiment
Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
A kind of cefradine sheet that infects due to sensitive organism and embodiment of preparation method for the treatment of of the present invention now proposed, the main component of the formula of this cefradine sheet is cefradine 250g, and adjuvant is: microcrystalline Cellulose 30-80g, lactose 10-30g, carboxymethylstach sodium 10-20g, magnesium stearate 2-8g, silica 1-5g, potassium hydrogen tartrate 05-2g, hypromellose 2-5g, polyacrylate resin 2-8g, magnesium stearate 1-5g, titanium dioxide 1-5g, Pulvis Talci 1-5g, lemon yellow 0.01-0.1g, 95% ethanol 100-150g.
The preparation method of this cefradine sheet, comprises the following steps:
(1) cefradine is pulverized, potassium hydrogen tartrate, microcrystalline Cellulose, lactose, carboxymethylstach sodium, magnesium stearate, silicon dioxide are sieved respectively;
(2) in cefradine, microcrystalline Cellulose, lactose, carboxymethylstach sodium (inside adding), potassium hydrogen tartrate, add 8% hypromellose to carry out wet granulation, rear dry granulate;
(3) dry granule and additional mixing of materials are even, and described additional material is carboxymethylstach sodium, magnesium stearate, silicon dioxide;
(4) tabletting;
(5) polyacrylate resin of getting recipe quantity, in stainless steel cask, to dissolving completely, soaks more than 6 hours by 95% soak with ethanol, after adding titanium dioxide, Pulvis Talci, magnesium stearate, lemon yellow to stir, sieve, the ethanol that adds again remaining recipe quantity, stirs, coating and get final product.
Through above-mentioned 5 steps, can be made into the cephalosporin-cefradine sheet infecting due to treatment of the present invention sensitive organism, operation is easy, makes simple, with low cost.
Cefradine sheet of the present invention in use, oral, adult's usual amounts: a 0.25～0.5g, every 6 hours 1 time, infect more severe case and once can increase to 1g, but a daily amount is no more than 4g; Children's's usual amounts: by 6.25～12.5mg/kg of body weight, every 6 hours 1 time.
The pharmacology of cefradine sheet of the present invention is as follows: cefradine sheet of the present invention is first generation cephalosporin, to not producing the part bacterial strain of the gram positive coccus such as penicillinase and product penicillinase staphylococcus aureus, coagulase negative staphylococcus, A group Hemolytic streptococcus, streptococcus pneumoniae, Streptococcus viridans, has good antibacterial action.Anaerobism gram positive bacteria is responsive to this product, and bacteroides fragilis presents drug resistance to this product.Methicillin-resistant Staphylococcus belongs to, Enterococcus presents drug resistance to this product.This product is similar to cefalexin to the effect of gram-negative bacteria to gram positive bacteria.This product has certain effect to Diplococcus gonorrhoeae, and to producing enzyme Diplococcus gonorrhoeae, also tool is active, poor to the activity of hemophilus influenza.Mechanism of action is identical with other cephalosporins, and mechanism of action is the synthetic of anti-bacteria cell wall.Above-mentioned various effective ingredient has significant curative effect for the infection due to sensitive organism, and patient is taken effect very soon, and drug effect is obvious, and treatment time is short, evident in efficacy.
In order to verify the curative effect of cefradine sheet of the present invention, done case test, curative effect judging standard: cure as symptom disappears completely, take effect for cardinal symptom disappears substantially, invalid is not change with treatment is front.Test situation is in 80 patients, male 50 examples, and female's 30 examples, maximum 65 years old, minimum 16 years old, result was to cure 55 examples, 24 examples that take effect, invalid 1 example, patient mostly uses in 12 hours and takes effect, and within 5-15 days, can cure, and effective percentage is more than 99%.Wherein 4 example test cases are as follows:
Case 1: Chen, man, 28 years old, suffer from acute pharyngitis, tonsillitis, with after the cephalosporin-cefradine sheet infecting due to treatment sensitive organism of the present invention, after 4 hours, take effect, recovery from illness afterwards in 5 days.
Case 2: appoint certain, female, 39 years old, suffer from urogenital infections, with after the cephalosporin-cefradine sheet infecting due to treatment sensitive organism of the present invention, after 4 hours, take effect, recovery from illness afterwards in 7 days.
Case 3: week certain, man, 16 years old, suffer from skin soft-tissue infection, with after the cephalosporin-cefradine sheet infecting due to treatment sensitive organism of the present invention, after 4 hours, take effect, within 7 days, fully recover afterwards.
Case 4: Zhang, man, 46 years old, suffer from otitis media, with after the cephalosporin-cefradine sheet infecting due to treatment sensitive organism of the present invention, after 4 hours, take effect, recovery from illness afterwards in 15 days.
Cephalosporin-cefradine the sheet infecting due to treatment sensitive organism of the present invention, for sensitive organism, infect and there is significant curative effect, with strong points, drug effect is obvious, treatment time is short, determined curative effect and significantly, the cefradine sheet infecting due to treatment sensitive organism of the present invention can enrich market medicine variety, to meet and to ensure better people's medication demand.And cefradine sheet production process of the present invention is simple, easy to make, cheap.It is obvious that the present invention has really realized a kind of drug effect, with strong points, instant effect, and determined curative effect and significantly, easy to make, the cephalosporin-cefradine sheet infecting due to cheap treatment sensitive organism.
The foregoing is only the preferred embodiments of the present invention; not thereby limit the scope of the claims of the present invention; every equivalent structure transformation that utilizes description of the present invention to do, or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410317953.0A CN104161738A (en) | 2014-07-07 | 2014-07-07 | Cefradine tablet for treating infection caused by sensitive bacteria and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410317953.0A CN104161738A (en) | 2014-07-07 | 2014-07-07 | Cefradine tablet for treating infection caused by sensitive bacteria and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104161738A true CN104161738A (en) | 2014-11-26 |
Family
ID=51905868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410317953.0A Pending CN104161738A (en) | 2014-07-07 | 2014-07-07 | Cefradine tablet for treating infection caused by sensitive bacteria and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104161738A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2210591A2 (en) * | 2009-01-26 | 2010-07-28 | Shin-Etsu Chemical Co., Ltd. | Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose |
| CN102106810A (en) * | 2010-11-25 | 2011-06-29 | 浙江震元制药有限公司 | Medicinal solid composition containing cephalosporin antibiotics and preparation method thereof |
-
2014
- 2014-07-07 CN CN201410317953.0A patent/CN104161738A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2210591A2 (en) * | 2009-01-26 | 2010-07-28 | Shin-Etsu Chemical Co., Ltd. | Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose |
| CN102106810A (en) * | 2010-11-25 | 2011-06-29 | 浙江震元制药有限公司 | Medicinal solid composition containing cephalosporin antibiotics and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典 2010年版 二部》", 31 January 2010, 中国医药科技出版社 * |
| 崔福德: "《药剂学》", 31 August 2007, 人民卫生出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101390837B (en) | Amoxicillin granule and production method thereof | |
| CN102008445B (en) | Amoxicillin soluble powder as well as preparation method and application thereof | |
| EP2114406B1 (en) | Thioxanthene derivates as sole anti-infective agents for use in the treatment of infectious diseases | |
| CN105920016B (en) | A kind of cefalexin tablet composition | |
| CN103520124A (en) | Levofloxacin hydrochloride tablet and preparation method thereof | |
| CN110075079A (en) | A kind of appropriate logical sequence pivoxil plain piece of spore, the appropriate logical sequence pivoxil piece of spore and preparation method | |
| CN104161738A (en) | Cefradine tablet for treating infection caused by sensitive bacteria and preparation method thereof | |
| CN103191114A (en) | Moxifloxacin-containing oral drug solid preparation and preparation method thereof | |
| CN102525949B (en) | Cefaclor composition particles and preparation method thereof | |
| CN103961351A (en) | Preparation method of amoxicillin and clavulanate potassium tablets | |
| CN102525948A (en) | Dry suspension of cefpodoxime proxetil composition and preparation method thereof | |
| CN104173303B (en) | Linezolid-containing composition and preparation method thereof | |
| CN104758941A (en) | Oral tablet capable of achieving rapid dissolution by using hydroxy propyl cellulose as adhesion agent | |
| CN101669943A (en) | Oral solid preparation of faropenem and salt derivative thereof | |
| CN102743388B (en) | Composition used for inhibiting bacteria generating novel beta lactamase | |
| CN102358749B (en) | Roxithromycin ambroxol tablet composite and preparing method thereof | |
| CN101502496A (en) | Method for preparing norfloxacin capsule | |
| CN111557897B (en) | Pharmaceutical composition containing nifuratel and preparation method thereof | |
| CN105769883A (en) | Compound sulfamethoxazole dispersible tablet and preparation method thereof | |
| CN104173310A (en) | Stable amoxicillin tablet composition, as well as preparation method and application thereof | |
| CN101305986A (en) | Lafutidine Tablet and its preparation method | |
| CN102861015B (en) | Stable amoxicillin and clavulanate potassium sustained release preparation and preparation technology | |
| CN102525982A (en) | Stable moxifloxacin hydrochloride medicinal composition | |
| CN110075078A (en) | A kind of Cefditoren pivoxil Cephalosporins composition and Cefditoren pivoxil Cephalosporins piece | |
| CN101502495A (en) | Pemirolast Potassium and technique for producing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141126 |