CN104147688A - Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof - Google Patents
Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof Download PDFInfo
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- CN104147688A CN104147688A CN201410374435.2A CN201410374435A CN104147688A CN 104147688 A CN104147688 A CN 104147688A CN 201410374435 A CN201410374435 A CN 201410374435A CN 104147688 A CN104147688 A CN 104147688A
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- plastic outer
- deionized water
- applicator
- tumor
- alginate material
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 10
- 238000002725 brachytherapy Methods 0.000 title abstract 2
- 239000000463 material Substances 0.000 claims abstract description 33
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229940072056 alginate Drugs 0.000 claims abstract description 24
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 24
- 229920000615 alginic acid Polymers 0.000 claims abstract description 24
- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 238000011282 treatment Methods 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000012528 membrane Substances 0.000 claims abstract 5
- 238000009434 installation Methods 0.000 claims abstract 3
- 239000000843 powder Substances 0.000 claims description 8
- 239000010985 leather Substances 0.000 claims description 6
- 239000007943 implant Substances 0.000 claims description 4
- 238000009826 distribution Methods 0.000 abstract description 3
- 210000002808 connective tissue Anatomy 0.000 description 18
- 238000007493 shaping process Methods 0.000 description 17
- 230000006978 adaptation Effects 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 6
- 238000002513 implantation Methods 0.000 description 6
- 238000001959 radiotherapy Methods 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- -1 deionized water compound Chemical class 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 1
- 208000019065 cervical carcinoma Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
本发明公开了一种快速成型自适应近距离后装施源器及其制作方法。本发明的快速成型自适应近距离后装施源器包括有采用粉状的藻酸盐材料与去离子水混合固化后形成的固化体，以及在固化体内部植入的施源管；所述固化体是将装有粉状藻酸盐材料与去离子水混合料的塑型外膜植入患者肿瘤治疗部位后形成的适合肿瘤形状的结构；所述施源管是在塑型外膜内的混合料固化后取出去掉塑型外膜后植入固化体内部。本发明在肿瘤近距离后装治疗过程中使患者可以得到一个适合自己的个体化施源器，通过该施源器得到一个三维适型的剂量分布，从而同时得到满意的肿瘤控制率和较少并发症发生，具有自适应治疗部位，成型速度快，操作简单、制作成本低等优点。The invention discloses a rapid prototyping self-adaptive short-distance post-installation source applicator and a manufacturing method thereof. The rapid prototyping self-adaptive short-distance post-loading source applicator of the present invention includes a solidified body formed by mixing and curing powdered alginate material and deionized water, and a source tube implanted inside the solidified body; The cured body is a structure suitable for the shape of the tumor formed after the plastic outer membrane containing the mixture of powdered alginate material and deionized water is implanted into the patient's tumor treatment site; the source tube is inside the plastic outer membrane After the mixture is solidified, it is taken out and removed from the plastic outer film, and then implanted into the solidified body. The present invention enables patients to obtain an individualized applicator suitable for themselves in the process of tumor brachytherapy, and obtain a three-dimensional conformal dose distribution through the applicator, thereby simultaneously obtaining satisfactory tumor control rate and less Complications occur, and it has the advantages of adapting to the treatment site, fast forming speed, simple operation, and low production cost.
Description
Technical field
The invention belongs to tumour radiotherapy apparatus field, be specifically related to closely rear source applicator and preparation method thereof of a kind of rapid shaping self adaptation.
Background technology
At present, along with the development of tumour radiotherapy technology, closely fill afterwards radiotherapy and start to be widely used among the treatment of malignant tumor.For some, cannot carry out the patients with terminal of operative treatment especially, radiotherapy is its most effectively treatment means, and closely fill afterwards radiotherapy, is bringing into play very important effect in whole therapeutic process.But present stage, the tumor apparatus for wave-energy source that closely after-loading therapy is used mostly is standardization apparatus for wave-energy source.Standardization apparatus for wave-energy source shape, volume are fixed.Standardization apparatus for wave-energy source adopts rare metal or high strength organic material to make more, expensive.Standardization apparatus for wave-energy source formed dose distribution in therapeutic process is fixed.For tumor patient, due to each patient's tumor shape, volume and to invade the position of profit different, when treating, standardization of application apparatus for wave-energy source cannot reach the accurate close-range treatment of three-dimensional of individuation, may cause the therapeutic dose deficiency or the normal structure excess that give, thus cause tumor control failure or side reaction serious.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, closely rear source applicator and preparation method thereof of a kind of rapid shaping self adaptation is provided.
For achieving the above object, the technical solution used in the present invention is as follows:
Rapid shaping self adaptation is a rear source applicator closely, and include and adopt the alginate material of powdery and the firming body of the mixing cured rear formation of deionized water, and at the inner stock pipe of implanting of firming body; Described firming body is will the structure of the applicable tumor shape forming behind the plastotype adventitia patients with implantation oncotherapy position of powder alginate material and deionized water compound be housed; Described stock pipe is to implant firming body inside after plastotype adventitia is removed in taking-up after the compound in plastotype adventitia solidifies.
Above-mentioned alginate material mixes with the ratio that deionized water adds water 20～25ml according to 10 grams of powder.
The present invention also provides a kind of closely method of rear source applicator of rapid shaping self adaptation of making, and the method is carried out in accordance with the following steps:
Step 1, chooses the alginate material of powdery, and alginate material is mixed by a certain percentage with deionized water, after mixing, adjusts and mixes evenly;
Step 2, mixes uniform material by tune and packs in plastotype adventitia, then will the plastotype adventitia patients with implantation oncotherapy position of step 1 gained compound be housed, and compacting, and itself and tumor area are fitted tightly;
Step 3, keeps the outer film location of plastotype motionless, after the material cured in plastotype adventitia, the plastotype adventitia that firming body is housed is taken out, and removes plastotype adventitia, with clear water, removes the disintegrating slag on firming body;
Step 4, at the inner stock pipe of implanting of firming body, obtains the only rear source applicator of distance of rapid shaping according to clinical requirement.
Further, in step 1, alginate material mixes with the ratio that deionized water adds water 20～25ml in 10 grams of powder.
Further, in step 2, described plastotype adventitia is the rubber film bag that thickness is less than 0.5mm, and its membranous wall is thin, and good toughness, with alginate material adhesion.
Further, in step 1, alginate material and deionized water are put into leather cup and adopt to adjust and mix cutter and adjusts and mix, mixing time, in 30 seconds, is adjusted while mixing with adjusting and is mixed cutter and mix by " 8 " font tune that pressurizes along leather cup wall, and material mixing is evenly distributed.
Rapid shaping self adaptation provided by the invention is rear source applicator closely, in tumor closely in after-loading therapy process, patient can obtain an individuation apparatus for wave-energy source that is applicable to oneself, by this apparatus for wave-energy source, obtain the dose distribution of a suitable type, thereby obtain satisfied tumor control rate and less complication occurs simultaneously, and this apparatus for wave-energy source has self adaptation therapentic part, shaping speed is fast, simple to operate, the advantages such as cost of manufacture is low, source applicator after adopting manufacture method of the present invention to make closely, rapidly and efficiently, cost is low, individual adaptability is good, therapeutic effect is good.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
The rapid shaping self adaptation of the embodiment of the present invention is rear source applicator closely, and include and adopt the alginate material of powdery and the firming body of the mixing cured rear formation of deionized water, and at the inner supply radiator duct of implanting of firming body; Firming body is will the structure of the applicable tumor shape forming behind the plastotype adventitia patients with implantation oncotherapy position of powder alginate material and deionized water compound be housed; Supply radiator duct is to implant firming body inside after plastotype adventitia is removed in taking-up after the compound in plastotype adventitia solidifies.Alginate material mixes with the ratio that deionized water adds water 20～25ml according to 10 grams of powder.
This rapid shaping self adaptation is rear source applicator closely, select alginate material as the material of rapid shaping, before treatment, be made into the firming body of an applicable tumor shape, then in firming body, implant the supply radiator duct road of clinical needs, form body apparatus for wave-energy source one by one.This rapid shaping self adaptation closely rear source applicator is specifically made as follows:
Step 1, choose the alginate material of powdery, the ratio that alginate material is added to water 20～25ml with deionized water in 10 grams of powder is mixed and is put into leather cup and adopt to adjust and to mix cutter and adjust and mix, mixing time is in 30 seconds, when tune is mixed, with tune, mix cutter and adjust and mix by the pressurization of " 8 " font along leather cup wall, material mixing is evenly distributed; Step 2, mixes even compound by tune and packs in the thin-walled plastotype adventitia of being made by quality of rubber materials, then will the plastotype adventitia patients with implantation oncotherapy position of gained compound be housed, and compacting, and itself and tumor area are fitted tightly; Step 3, keeps the outer film location of plastotype motionless, after the material cured in plastotype adventitia, the plastotype adventitia that firming body is housed is taken out, and removes plastotype adventitia, with clear water, removes the disintegrating slag on firming body; Step 4, at the inner supply radiator duct of implanting of firming body, obtains closely rear source applicator of rapid shaping according to clinical requirement.Apparatus for wave-energy source of the present invention, when making, by being equipped with before the plastotype adventitia patients with implantation oncotherapy position of compound, need to fix position to patient, and therapentic part is exposed to sterilization.
Adopt manufacture method of the present invention to make closely rear source applicator of this rapid shaping self adaptation, always make working time 4-10 minute, wherein adjust and mix and only need 2-3 minute hardening time.And closely, suitable type is good, is easy to individualized treatment for made apparatus for wave-energy source and the laminating of oncotherapy district.
The rapid shaping self adaptation that the embodiment of the present invention obtains is rear source applicator closely, draws by experiment, and the deformation recovery value of apparatus for wave-energy source is 95%; Compressive strain value is between 5%～20%; Comprcssive strength is 0.35MPa.
Experimental Comparison: for stump recurrence patient after operation for cervical carcinoma, tumor is invaded profit along postoperative stump to intraperitoneal.Carrying out tumor closely during afterloading irradiation, standardization of application apparatus for wave-energy source can only be treated 1/3 pre-defence area and tumor stump surface on vagina, cannot to Intraabdominal tumor area, carry out plesioradiotherapy to invading profit.
The rapid shaping of the application of the invention is rear source applicator closely, produces the apparatus for wave-energy source that is applicable to this patient, and apparatus for wave-energy source comprises a plurality of supply radiator ducts, can carry out tissue space implantation.Whole apparatus for wave-energy source irradiates when can accomplish to take into account on vagina 1/3 pre-defence area and recurrent tumor district.The manufacturing process of whole apparatus for wave-energy source is 3 minutes, use this rapid shaping closely after source applicator can make whole tumor area can reach 98% prescribed dose.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410374435.2A CN104147688A (en) | 2014-07-31 | 2014-07-31 | Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof |
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| CN201410374435.2A CN104147688A (en) | 2014-07-31 | 2014-07-31 | Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof |
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| CN2426743Y (en) * | 2000-05-16 | 2001-04-18 | 佛山市第一人民医院 | Device for applying media in cavum nasopharyngeum |
| CN2427231Y (en) * | 2000-05-29 | 2001-04-25 | 陈宝明 | Apparatus for post-erection of wave-energy source (or the like) for vagina |
| WO2007134126A2 (en) * | 2006-05-09 | 2007-11-22 | Worldwide Medical Technologies Llc | After-loader devices and kits and methods for their use |
| CN101516432A (en) * | 2006-07-28 | 2009-08-26 | 得克萨斯大学体系董事会 | Adaptive intracavitary brachytherapy applicator |
| CN102798540A (en) * | 2012-07-20 | 2012-11-28 | 同济大学 | Method for quickly and stably picking fragile tissue of animal for experiments |
| CN103736200A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Preparation method of radioactive particle chain |
| CN103957984A (en) * | 2011-09-30 | 2014-07-30 | 纪念斯隆-凯特林癌症中心 | Internal body cavity therapeutic applicator arrangements and methods for using the same |
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2014
- 2014-07-31 CN CN201410374435.2A patent/CN104147688A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084002A (en) * | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
| CN1130133A (en) * | 1994-11-22 | 1996-09-04 | 照明及图象公司 | Scultapture article and its making method |
| CN1177609A (en) * | 1997-06-20 | 1998-04-01 | 张冬青 | Formula for making structural section of children's hand and foot mould, and production process thereof |
| WO1999055386A2 (en) * | 1998-04-10 | 1999-11-04 | Battelle Memorial Institute | Stimulus sensitive gel with radioisotope and methods of making |
| CN2426743Y (en) * | 2000-05-16 | 2001-04-18 | 佛山市第一人民医院 | Device for applying media in cavum nasopharyngeum |
| CN2427231Y (en) * | 2000-05-29 | 2001-04-25 | 陈宝明 | Apparatus for post-erection of wave-energy source (or the like) for vagina |
| WO2007134126A2 (en) * | 2006-05-09 | 2007-11-22 | Worldwide Medical Technologies Llc | After-loader devices and kits and methods for their use |
| CN101516432A (en) * | 2006-07-28 | 2009-08-26 | 得克萨斯大学体系董事会 | Adaptive intracavitary brachytherapy applicator |
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Application publication date: 20141119 |
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