CN1041436C - Prescription for stabilizator of rheumatism-traumatic medicinal liquor - Google Patents
Prescription for stabilizator of rheumatism-traumatic medicinal liquor Download PDFInfo
- Publication number
- CN1041436C CN1041436C CN93105506A CN93105506A CN1041436C CN 1041436 C CN1041436 C CN 1041436C CN 93105506 A CN93105506 A CN 93105506A CN 93105506 A CN93105506 A CN 93105506A CN 1041436 C CN1041436 C CN 1041436C
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- CN
- China
- Prior art keywords
- medicinal liquor
- glycerine
- ethylene diamine
- diamine tetraacetate
- disodium ethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Medicines Containing Plant Substances (AREA)
- Alcoholic Beverages (AREA)
Abstract
The present invention discloses a prescription of a stabilizing agent of rheumatism and traumatism medicinal wine, which is composed of glycerin and disodium edta. The stability of the medicinal wine is greatly enhanced by applying the stabilizing agent, and pharmacopoeia specifications and other indexes are all not influenced.
Description
The present invention relates to stablize the method for FENGLIAOXING FENGSHI DIEDA YAOJIU.
FENGLIAOXING FENGSHI DIEDA YAOJIU is a kind of medicinal liquor of classics, and pharmacopeia was collected in 9 years.But this medicinal liquor is after storing for some time (about 3 months) at present, and especially regular meeting becomes turbid under the lower situation of temperature, has influenced the outward appearance and the mouthfeel of this medicine, makes the patient be difficult for accepting.
The object of the present invention is to provide a kind of method of stablizing this medicinal liquor, can improve the clarity of medicinal liquor, prevent the turbidity and precipitation of medicinal liquor, improve the quality of this medicinal liquor by method of the present invention.
The present invention is achieved by adding ethylenediamine tetraacetic acid disodium (EDTA-2Na) and glycerine in medicinal liquor.
Impel the factor of FENGLIAOXING FENGSHI DIEDA YAOJIU turbidity and precipitation to mainly contain: (1) because temperature is low and the alcohol volatilization, so that solute supersaturation and separating out; (2) part is built up sedimentation owing to medicinal liquor filters the particulate of not staying entirely in the solution; (3) metal ion in the wine liquid promotes that particulate is built up sedimentation in the wine liquid.Add stablizer, the adding of (1) glycerine increases the viscosity of wine liquid, suppresses the accumulation sedimentation of particulate in the wine liquid; (2) adding EDTA-2Na makes with metal ion and forms stable complex compound, suppresses metal ion particulate in the solution is built up settled promoter action.
In the medicinal liquor, the amount of EDTA-2Na can be between 0.005～0.15% (g/ml), and the amount of glycerine can be between 0.5～5.0% (g/ml).
The present invention is further illustrated below in conjunction with embodiment.
For being fit to the application of FENGLIAOXING FENGSHI DIEDA YAOJIU suitability for industrialized production, according to the mean value 936g/l of every liter of density of this medicinal liquor, with the concentration of glycerine 2.5% (g/ml), EDTA-2Na 0.075% (g/ml), the ratio that is converted to medicinal liquor and stablizer is:
Medicinal liquor: EDTA-2Na: glycerine=1000: 0.79: 27 (weight ratio)
Glycerine directly adds.EDTA-2Na is mixed with the aqueous solution with warm water and adds as being mixed with 10% solution.Get medicated liquor, earlier the EDTA-2Na aqueous solution is added in the wine liquid, the limit edged stirs, again glycerine is slowly added under stirring state after adding, and mixing, promptly.
The sample that adds stablizer, minimum through the check of Guangdong Province medicine inspecting institute to containing the influence of alcohol amount, adopt version standards of pharmacopoeia check in 90 years, the equal conformance with standard regulation of projects.Stability test shows, even be low to moderate under-17 ℃ the situation, the medicinal liquor that adds stablizer still can keep clarification in 7 days not have precipitation, and the medicinal liquor (reference substance) that does not add stablizer is under 4 ℃ situation, promptly occurs precipitation in 4 days.After showing the adding stablizer, can improve the stability of medicinal liquor greatly.Its test-results sees Table one:
Table one.
| Sample | Dwell temperature | Leave standstill fate | The result |
| Sample 1 reference substance 1 | Room temperature | 300 300 | Liquid is clear, and no precipitated liquid is turbid, and more precipitation is arranged |
| Sample 2 reference substances 2 | 4 | 143 3 | Liquid is clear, and no precipitated liquid is turbid slightly, and precipitation is arranged |
| Sample 3 reference substances 3 | 37 | 210 210 | Liquid is clear, and no precipitated liquid is clear, does not have precipitation |
| Sample 4 reference substances 4 | -17 | 7 7 | Liquid is clear, and upward liquid is clear not have precipitation, and more precipitation is arranged |
Experimental study shows, is the detection by quantitative index with the effective constituent Scopolamine of main ingredient Stem of Obtuseleaf Erycibe, do not compare no change with adding stablizer medicinal liquor, sense of taste no change.
The toxicological experiment that rat gavaged in 30 days shows that toxicity is not had influence.
In a word, the adding of stablizer has improved the stability of medicinal liquor greatly, and every index is not all had influence.
The prescription of stablizer of the present invention can be applicable to other medicinal liquor.
Claims (2)
1. the method for a stable FENGLIAOXING FENGSHI DIEDA YAOJIU is achieved by adding disodium ethylene diamine tetraacetate and glycerine in medicinal liquor; Add-on is the amount meter with respect to medicinal liquor, and disodium ethylene diamine tetraacetate is between 0.005～0.15%g/ml, and the amount of glycerine is between 0.5～5.0%g/ml; Addition sequence is that the limit edged stirs in the aqueous solution adding wine liquid of elder generation with disodium ethylene diamine tetraacetate, again glycerine slowly added under stirring state, and mixing, promptly.
2. the method for stable FENGLIAOXING FENGSHI DIEDA YAOJIU according to claim 1 is characterized in that the amount meter with respect to medicinal liquor, and disodium ethylene diamine tetraacetate is 0.075g/ml, and glycerine is 2.5g/ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93105506A CN1041436C (en) | 1993-05-07 | 1993-05-07 | Prescription for stabilizator of rheumatism-traumatic medicinal liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93105506A CN1041436C (en) | 1993-05-07 | 1993-05-07 | Prescription for stabilizator of rheumatism-traumatic medicinal liquor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1094752A CN1094752A (en) | 1994-11-09 |
| CN1041436C true CN1041436C (en) | 1998-12-30 |
Family
ID=4985754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93105506A Expired - Fee Related CN1041436C (en) | 1993-05-07 | 1993-05-07 | Prescription for stabilizator of rheumatism-traumatic medicinal liquor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1041436C (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031714A (en) * | 1988-06-23 | 1989-03-15 | 刘高明 | The manufacture method of tonic Zhang Zhu liquior |
| CN1051905A (en) * | 1989-11-13 | 1991-06-05 | 美国辉瑞有限公司 | In split and institute's deutero-medicament to the enzymatic of dicyclo [2,2,1] heptan-2-alcohol |
-
1993
- 1993-05-07 CN CN93105506A patent/CN1041436C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031714A (en) * | 1988-06-23 | 1989-03-15 | 刘高明 | The manufacture method of tonic Zhang Zhu liquior |
| CN1051905A (en) * | 1989-11-13 | 1991-06-05 | 美国辉瑞有限公司 | In split and institute's deutero-medicament to the enzymatic of dicyclo [2,2,1] heptan-2-alcohol |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1094752A (en) | 1994-11-09 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |