CN104126609B - For cleaning colpomicroscopic thimerosal and preparation method thereof - Google Patents

Abstract

The invention discloses a disinfectant solution for cleaning colposcopes. In terms of components by weight, peracetic acid is 0.5%-1.0%, hydrogen peroxide is 2.0%-5.0%, chlorhexidine hydrochloride is 0.1%-0.5%, and phenol 0.01%‑0.05%, salicylic acid 1.0%‑5.0%, trichloroisocyanuric acid 2.0%‑6.0%, and the balance is water. The colposcope cleaning and disinfecting solution developed by the invention has a colorless and transparent appearance, stable physical and chemical indicators, no crystallization, turbidity, and precipitation during use, and stable performance of various physical and chemical indicators. Compared with the prior art, the production cost of the disinfectant prepared by the invention is low, the preparation process is simple, the process conditions are easy to realize, and the product stability is good.

Description

Disinfectant for cleaning colposcope and preparation method thereof

technical field

The invention relates to a disinfectant, in particular to a disinfectant for cleaning colposcopes and a preparation method thereof.

Background technique

Colposcope is one of gynecological endoscopes and an important method for early diagnosis of male and female diseases. It is suitable for the diagnosis of various cervical diseases and genital lesions. Minor lesions that cannot be detected. With this magnification effect, doctors can clearly see the extremely small details of lesions on the epidermis of the cervix and genitals, which helps to improve the accuracy of judging lesions of the cervix and genitals, and provides a basis for early diagnosis of the disease. Get effective treatment in advance, so that the cure rate of the disease is greatly improved. When performing colposcopy, you only need to use a speculum to expose the vagina, cervix and genitals. At a distance of about 20 cm from the vaginal opening or genitals, align the lens of the colposcope with the upper epidermal tissue of the cervix or genitals. A magnified image of the cervix or epidermis of the genitals is viewed on the screen. The computer can store and playback these images, which is convenient for follow-up observation of treatment effect. During the examination, the patient is painless. Therefore, colposcopy has been widely used in the examination of vaginal and cervical diseases and genital lesions, and is known as the "golden eye" of doctors. Thus deeply loved by the majority of patients and doctors, widely used.

Colposcope classification: 1. Classified by function: (1) Diagnostic colposcope, also known as standard colposcope: This colposcope is only suitable for inspection, and there is no special energy matching for colposcopy surgery. (2) Diagnosis and treatment colposcope: This type of colposcope is a combination of ordinary colposcope and special energy, such as laser combined colposcope, etc. This colposcope can be equipped with a coaxial laser while performing colposcopy. For local laser surgery. 2. Classification by imaging system: (1) Optical colposcope: refers to a colposcope that images through an optical lens system. (2) Electronic colposcope: refers to a colposcope that converts optical information into digital information imaging through CCD. 3. Classified by data storage method: (1) Ordinary colposcope: refers to colposcope accessories that do not contain a computer part, and colposcopy examination data are still stored in traditional handwriting. Image acquisition is mainly based on photography and video recording. (2) Computerized colposcope: refers to the optical or electronic colposcope accessories that include a computer graphic information management system. The colposcope data is stored in the computer in a standard computerized language and real-time image acquisition. 4. According to mechanical classification: colposcope is divided into two series, namely electronic colposcope and photoelectric colposcope. Electronic colposcopy is the first to use, using digital electronic imaging technology to diagnose cervical diseases through the colposcope imaging system; the photoelectric integrated colposcope integrates the advantages of microscope optical system and electronic colposcope imaging system and is designed for a new generation of applications Advanced equipment for clinical diagnosis of cervical lesions.

Colposcope structure: 1. Optical colposcope Optical colposcope mainly consists of four parts: mirror body, bracket, light source and accessories. (1) Mirror body: Located on the top of the bracket, it is equipped with tilt adjustment and left and right adjustment handles to ensure that the mirror body can rotate freely. There are two objective lenses in front, light source outlet and color filter lens. There are binocular eyepieces at the rear end, and the distance between the binoculars is adjusted based on the interpupillary distance of the examiner, so that the images of the two eyepieces overlap to form an optimal stereoscopic image. (2) Bracket: There are two types: land type and suspension type. The choice of stent mainly depends on the conditions of the colposcopy clinic. (3) Light source: There are two kinds of light source inside the mirror and cold light source outside the mirror. (4) Accessories: including camera system (ordinary camera, stereo camera and primary imaging system), video recording system, printing system and computer graphic information management system, etc. 2. Electronic colposcope: Electronic colposcope includes camera part, processor part, light source part, bracket part and software part. The photoelectric integrated colposcope includes a cold light source part, an optical part, a processor part and a software part.

At present, there are few disinfectant solutions for cleaning colposcopes in the existing patents. The patent with publication number 101720760A (application number 200810157978.3) discloses a multifunctional disinfectant solution for hemodialysis machines, which mainly uses peracetic acid and hydrogen peroxide. The raw materials are mixed by adding stabilizer salicylic acid, EDTA disodium salt, and 8-hydroxyquinoline. The specific composition weight percentage is: peracetic acid 4.0%-6.0%, hydrogen peroxide 18.0%-22.0%, salicylic acid 0.3%-1.5%, EDTA disodium salt 0.3%-1.0%, 8-hydroxyquinoline 0.3%-1.0%, the balance is water. Publication No. 103766377A (Application No. 201210416140.8) discloses a citric acid decalcification disinfectant used in dialysis machines and water treatment and its preparation method. The disinfectant includes polyhexamethylene guanidine, citric acid, lactic acid, apple acid, and the balance is deionized water. The composition ratio of the disinfectant is 0.001-5.0% of polyhexamethyleneguanidine, 10-50% of citric acid, 20.0%-40% of lactic acid, 10%-30% of malic acid, and the balance is deionized water. This disinfectant is prepared from citric acid, polyhexamethylene guanidine, lactic acid and malic acid as main raw materials. Publication No. 101664043 (Application No. 200910307991.7) discloses a disinfectant for disinfecting and cleaning the waterways of hemodialysis machines and its preparation method, which is made of citric acid, acid regulator, acid protease, high-purity water and hydrogen peroxide; Among them, the mass concentration of the acid regulator in the disinfectant for disinfecting and cleaning the waterway of the hemodialysis machine is 2%-5%, and the mass concentration of the acidic protease in the disinfectant for disinfecting and cleaning the waterway of the hemodialysis machine is 3000-6000 SAPU/100ml. The mass concentration of hydrogen oxide in the disinfectant solution for disinfecting and cleaning the waterway of hemodialysis machines is 8%-10%, and the mass concentration of citric acid in the disinfectant solution for disinfecting and cleaning the waterway of hemodialysis machines is 40%-50%.

It can be seen that the disinfectant has a good bactericidal effect in cleaning medical equipment, but there are still some deficiencies in the prior art including the above-mentioned patent documents. First of all, the existing related technologies are relatively few, and there is no door Disinfectant solution for cleaning colposcope machines.

Contents of the invention

The technical problem to be solved by the present invention is to overcome the shortcomings of poor stability of colposcope machine cleaning and disinfectant in the prior art. One of the purposes of the present invention is to provide a stable, safe, non-toxic and stable It is a disinfectant solution for cleaning and disinfecting colposcope machines with better performance. Another object is exactly to provide the preparation method of above-mentioned disinfectant.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Disinfectants for cleaning colposcopes, by weight components, peracetic acid 0.5%-1.0%, hydrogen peroxide 2.0%-5.0%, chlorhexidine hydrochloride 0.1%-0.5%, phenol 0.01%-0.05%, Salicylic acid 1.0%-5.0% (preferably, salicylic acid 1.2%-4.5%; more preferably, salicylic acid 3.5%), trichloroisocyanuric acid 2.0%-6.0%, and the balance is water.

According to the aforementioned disinfectant solution for cleaning colposcopes, the preferred scheme is: in terms of weight components: peracetic acid 0.6%-0.9%, hydrogen peroxide 2.5%-4.5%, chlorhexidine hydrochloride 0.2%- 0.4%, phenol 0.02%-0.04%, salicylic acid 2.0%-4.0%, trichloroisocyanuric acid 3.0%-5.0%, and the balance is water.

According to the aforementioned disinfectant solution for cleaning colposcopes, the more preferred solution is, in terms of weight components, peracetic acid 0.8%, hydrogen peroxide 3.0%, chlorhexidine hydrochloride 0.3%, phenol 0.03%, Salicylic acid 3.0%, trichloroisocyanuric acid 4.0%, and the balance is water.

According to any one of the preparation methods for cleaning colposcope disinfectant, comprising the following steps:

(1) Add chlorhexidine hydrochloride, phenol and salicylic acid into the liquid preparation tank, add trichloroisocyanuric acid after 2-6 minutes, add water after standing for 1-3 hours, stir at 40-60°C for 0.5 After -1.5 hours, the buffer solution was obtained, and then the temperature of the buffer solution was lowered to -5-0°C;

(2) Add hydrogen peroxide and peracetic acid dropwise to the buffer solution obtained in step (1), and continue stirring for 0.5-1 hour to obtain a disinfectant;

(3) Filter the disinfectant solution obtained in step (2) through a microporous membrane, and pack it separately.

According to the above-mentioned preparation method, the preferred solution is: step (1) add trichloroisocyanuric acid after 3-5 minutes, add water after standing for 1.5-2.5 hours (preferably add trichloroisocyanuric acid after 4 minutes, Add water after standing for 2 hours).

According to the above-mentioned preparation method, the preferred solution is: step (1) obtain a buffer solution after stirring at 45-55° C. for 0.6-0.8 hours (preferably obtain a buffer solution after stirring at 50° C. for 1 hour).

According to the aforementioned preparation method, the preferred solution is: step (1) lowering the temperature of the buffer solution to -4 to -2°C (preferably lowering the temperature of the buffer solution to -3°C).

According to the above-mentioned preparation method, the preferred solution is: step (2) continue to stir for 0.5-0.8 hours to obtain a disinfectant solution (preferably continue to stir for 0.6 hours to obtain a disinfectant solution).

According to the aforementioned preparation method, the preferred solution is: the pore diameter of the microporous membrane in step (3) is 0.10-0.45 μm (preferably 0.22 μm).

According to the application of the disinfectant solution for cleaning colposcope according to any one of the foregoing when preparing the disinfectant solution for colposcope machine, B-ultrasonic instrument, and CT machine.

The introduction of each raw material is as follows:

Peracetic Acid: It is a colorless liquid with the typical odor of acetic acid. Peracetic acid is a strong oxidizing agent. In the pharmaceutical industry, it is used as a disinfectant for drinking water, food and preventing infectious diseases. Peracetic acid is a strong oxidizing agent and has strong oxidizing properties. When it encounters organic matter, it releases new ecological oxygen to oxidize. It is used as a medical or life disinfection drug together with sodium hypochlorite (also known as 84 disinfectant) and bleaching powder. It is highly effective and quick-acting. , low toxicity, broad-spectrum fungicide, has killing effect on bacterial propagules, spores, viruses and molds. Therefore, it can be used for sterilization and disinfection. In addition, because peracetic acid has strong volatility in the air, it has a good effect on sterilization and disinfection of the air, and it is cheap. At present, the main sterilization and disinfectant we use to prevent SARS is peracetic acid.

Hydrogen peroxide: Commonly known as hydrogen peroxide, it has a faint special smell and can be used as a disinfectant. Pure hydrogen peroxide is a light blue oily liquid. Can be mixed with water, ethanol or ether in any proportion. Hydrogen peroxide is a colorless liquid with a pungent odor. Medically, 3% hydrogen peroxide is commonly used to disinfect wounds or otitis media. When it meets wounds, pus or dirt on the skin, oral cavity and mucous membranes, it immediately decomposes to generate oxygen. This oxygen atom, which has not yet been combined into oxygen molecules, has a strong oxidizing ability. When it comes into contact with bacteria, it can destroy the bacterial cells and kill the bacteria. The remaining substance after killing the bacteria is water without any poison or irritation. No secondary pollution will be formed. Therefore, hydrogen peroxide is an ideal disinfectant for wound disinfection. However, it should be noted that high-concentration hydrogen peroxide cannot be used for wound disinfection to prevent burns to the skin and affected areas.

Chlorhexidine hydrochloride: Chlorhexidine hydrochloride is a disinfectant and preservative. Its antibacterial and bactericidal effects are broad and strong. It has a stronger antibacterial effect on Gram-positive bacteria than negative bacteria, and is stronger than quaternary ammonium cationic surfactants. It is also effective against fungi, but not against acid-fast bacteria, spores and viruses. It is still effective in the presence of serum and blood. Non-irritating to tissues, white or almost white crystalline powder; odorless, bitter taste. Very slightly soluble in water, slightly soluble in ethanol, slightly soluble in propylene glycol.

Phenol: Phenol (Phenol, C6H5OH) is a colorless needle-shaped crystal with a special odor, which is toxic and is an important raw material for the production of certain resins, fungicides, preservatives and drugs (such as aspirin). It can also be used for disinfection of surgical instruments and treatment of excrement, skin sterilization, antipruritic and otitis media. Slightly soluble in water at room temperature, easily soluble in organic solvents; when the temperature is higher than 65°C, it can be miscible with water in any proportion. Phenol is corrosive and will denature local proteins after contact. Its solution can be washed with alcohol when it touches the skin. Phenol turns pink when exposed to air and is oxidized to quinone by oxygen.

Salicylic acid: Salicylic acid is a fat-soluble organic acid, so it can easily disintegrate excess sebum on the skin surface, and at the same time inhibit excessive sebum secretion. It also has a strong dissolution effect on corner plugs and acne caused by sebum blockage , improve the unclean state of the hair follicle wall, help sebum to be removed from the pores smoothly, and at the same time use the antibacterial properties to quickly dry up acne. Salicylic acid can dissolve cells and the substances used for connection between cells, so that aging keratinocytes can be quickly shed from the skin surface, thereby promoting skin metabolism and restoring the delicate touch of the skin. Pigmentation on the surface of the skin usually occurs in the unhealthy keratinocyte layer. The use of salicylic acid can help peel off this layer of aging keratinocytes, just like a mirror that has been wiped clean to restore a clear and clear impression. In addition, salicylic acid can assist the penetration of other acidic whitening ingredients, and salicylic acid is often used as a stabilizer.

Trichloroisocyanuric acid, an organic compound, white crystalline powder or granular solid, has a strong chlorine gas pungent smell. Trichloroisocyanuric acid is a very strong oxidizing agent and chlorinating agent. It has high-efficiency, broad-spectrum and relatively safe disinfection effect. It has a killing effect on bacteria, viruses, fungi, spores, etc. Definitely killing effect. It has a killing effect on almost all fungi, bacteria, and viral spores. It has special effects on killing hepatitis A and hepatitis B viruses. It also has a good disinfection effect on sexual viruses and HIV. It is safe and convenient to use. This product can also be widely used in Food, dairy products, rice seed treatment, fruit preservation, fiber bleaching, wool anti-shrinkage, daily chemical decolorization, wood anti-mold papermaking, rubber oxidation and battery materials, etc.

The colposcope cleaning and disinfecting solution developed by the invention has a colorless and transparent appearance, stable physical and chemical indicators, no crystallization, turbidity, and precipitation during use, and stable performance of various physical and chemical indicators. Compared with the prior art, the production cost of the disinfectant prepared by the invention is low, the preparation process is simple, the process conditions are easy to realize, and the product stability is good.

detailed description

The technical solutions of the present invention will be described in detail below in conjunction with the examples and experimental examples, but the scope of protection is not limited thereto.

Example 1 A disinfectant solution for cleaning colposcopes, by weight components: 0.5% peracetic acid, 2.0% hydrogen peroxide, 0.1% chlorhexidine hydrochloride, 0.01% phenol, 1.0% salicylic acid, three Chloroisocyanuric acid 2.0%, the balance is water.

A kind of preparation step for the disinfectant solution of cleaning colposcope is as follows:

(1) Add chlorhexidine hydrochloride, phenol and salicylic acid into the liquid preparation tank, add trichloroisocyanuric acid after 2 minutes, add water after standing for 1 hour, and stir at 40°C for 0.5 hours to obtain a buffer solution, Then lower the temperature of the buffer solution to -5°C;

(2) Add hydrogen peroxide and peracetic acid dropwise to the buffer solution obtained in step (1), and continue stirring for 0.3 hours to obtain a disinfectant;

(3) Filter the disinfectant solution obtained in step (2) through a microporous membrane, and pack it separately.

Stability test 1: Take the disinfectant solution obtained in Example 1 above for cleaning and disinfection of colposcopes, and conduct a stability test with reference to the 2002 edition of "Technical Specifications for Disinfection". Storage conditions: at 37°C, testing environment: temperature 30°C Humidity 40%-44%. The results are shown in Table 1 below:

Table 1

Prove by 37 ℃ of accelerated tests, the active ingredient peracetic acid and the content of hydrogen peroxide of the disinfectant liquid that embodiment 1 gained is used for cleaning and disinfecting colposcope do not descend substantially, and only a small amount of hydrogen peroxide decomposes; Show that the present invention uses The disinfectant used for cleaning and disinfecting colposcopes has good stability and will not undergo a large amount of decomposition during storage and transportation.

Embodiment 2 A kind of disinfectant for cleaning colposcope, by weight components: peracetic acid 1.0%, hydrogen peroxide 5.0%, chlorhexidine hydrochloride 0.5%, phenol 0.05%, salicylic acid 5.0%, three Chloroisocyanuric acid 6.0%, the balance is water.

A kind of preparation step for the disinfectant solution of cleaning colposcope is as follows:

(1) Add chlorhexidine hydrochloride, phenol and salicylic acid into the liquid preparation tank, add trichloroisocyanuric acid after 6 minutes, add water after standing for 3 hours, and stir at 60°C for 1.5 hours to obtain a buffer solution. Then lower the temperature of the buffer solution to 0°C;

(2) Add hydrogen peroxide and peracetic acid dropwise to the buffer solution obtained in step (1), and continue stirring for 1 hour to obtain a disinfectant;

(3) Filter the disinfectant solution obtained in step (2) through a microporous membrane, and pack it separately.

Stability test 2: Take the disinfectant used for cleaning and disinfecting colposcopes obtained in Example 2 above, and conduct a stability test with reference to the 2002 edition of "Technical Specifications for Disinfection". Storage conditions: place at 37°C. Testing environment: temperature 30°C, relative humidity 40%-44%. The results are shown in Table 2 below:

Table 2

Prove by 37 ℃ of accelerated tests, the content of active ingredient peracetic acid and hydrogen peroxide of the disinfectant liquid that embodiment 2 gained is used for cleaning and disinfecting colposcope does not descend substantially, and only a small amount of hydrogen peroxide decomposes; Show that the present invention uses The disinfectant used for cleaning and disinfecting colposcopes has good stability and will not undergo a large amount of decomposition during storage and transportation.

Example 3 A disinfectant for cleaning colposcopes, in terms of weight components: 0.6% peracetic acid, 2.5% hydrogen peroxide, 0.2% chlorhexidine hydrochloride, 0.02% phenol, 2.0% salicylic acid, three Chloroisocyanuric acid 3.0%, the balance is water.

A kind of preparation step for the disinfectant solution of cleaning colposcope is as follows:

(1) Add chlorhexidine hydrochloride, phenol and salicylic acid into the mixing tank, add trichloroisocyanuric acid after 3 minutes, add water after standing for 1.5 hours, and stir at 45°C for 0.8 hours to obtain a buffer solution. Then lower the temperature of the buffer solution to -4°C;

(2) Add hydrogen peroxide and peracetic acid dropwise to the buffer solution obtained in step (1), and continue stirring for 0.5 hours to obtain a disinfectant;

(3) Filter the disinfectant solution obtained in step (2) through a microporous membrane, and pack it separately.

Stability test 3: Take the disinfectant solution used for cleaning and disinfecting colposcopes prepared in Example 3 above, and conduct a stability test with reference to the 2002 edition of "Technical Specifications for Disinfection". Storage conditions: place at 37°C. Testing environment: temperature 30°C, relative humidity 40%-44%. The results are shown in Table 3 below:

table 3

Prove by 37 ℃ of accelerated tests, the content of active ingredient peracetic acid and hydrogen peroxide of the disinfectant liquid that embodiment 3 gained is used for colposcope cleaning and disinfection does not decline substantially, and only a small amount of hydrogen peroxide decomposes; Show that the present invention uses The disinfectant used for cleaning and disinfecting colposcopes has good stability and will not undergo a large amount of decomposition during storage and transportation.

Example 4 A disinfectant solution for cleaning colposcopes, by weight components: 0.9% peracetic acid, 4.5% hydrogen peroxide, 0.4% chlorhexidine hydrochloride, 0.04% phenol, 4.0% salicylic acid, three Chloroisocyanuric acid 5.0%, the balance is water.

A kind of preparation step for the disinfectant solution of cleaning colposcope is as follows:

(1) Add chlorhexidine hydrochloride, phenol and salicylic acid into the liquid preparation tank, add trichloroisocyanuric acid after 5 minutes, add water after standing for 2.5 hours, and stir at 55°C for 1.3 hours to obtain a buffer solution. Then lower the temperature of the buffer solution to -4°C;

(2) Add hydrogen peroxide and peracetic acid dropwise to the buffer solution obtained in step (1), and continue stirring for 0.8 hours to obtain a disinfectant;

(3) Filter the disinfectant solution obtained in step (2) through a microporous membrane, and pack it separately.

Example 5 A disinfectant for cleaning colposcopes, by weight components, peracetic acid 0.8%, hydrogen peroxide 3.0%, chlorhexidine hydrochloride 0.3%, phenol 0.03%, salicylic acid 3.0%, three Chloroisocyanuric acid 4.0%, the balance is water.

A kind of preparation step for the disinfectant solution of cleaning colposcope is as follows:

(1) Add chlorhexidine hydrochloride, phenol and salicylic acid into the mixing tank, add trichloroisocyanuric acid after 4 minutes, add water after standing for 2 hours, and stir at 50°C for 1 hour to obtain a buffer solution. Then lower the temperature of the buffer solution to -3°C;

(2) Add hydrogen peroxide and peracetic acid dropwise to the buffer solution obtained in step (1), and continue stirring for 0.7 hours to obtain a disinfectant;

(3) Filter the disinfectant solution obtained in step (2) through a microporous membrane, and pack it separately.

Experimental example 1: the disinfectant solution prepared in embodiment 5 is used Candida, mould, Staphylococcus and Neisseria gonorrhoeae to the disinfection simulation field test of medical equipment:

Candida suspension, mold suspension, Staphylococcus suspension and Neisseria gonorrhoeae suspension were drip-stained on the inside of polytetrafluoroethylene tubes, spread evenly, and placed in a 37°C constant temperature incubator to dry to prepare bacteria-contaminated carriers. With the product of the present invention gained as disinfectant, carry out cleaning and disinfection according to colposcope machine instruction manual disinfection procedure, the result is as shown in table 4 below:

Table 4 This disinfectant kills the logarithmic value of bacteria

The results showed that the logarithmic value of this product against Candida, mold, Staphylococcus and Neisseria gonorrhoeae stained on the polytetrafluoroethylene tube was >5.89, indicating that this product has a good sterilization and disinfection effect.

Experimental Example 2: In order to verify the sterilization and disinfection effect of the disinfectant solution obtained in Example 5, the candida suspension, mold suspension, staphylococcus suspension and gonorrhea suspension were respectively drip-stained on the inside of the polytetrafluoroethylene tube and coated evenly , placed in a constant temperature incubator at 37°C and dried to prepare the bacteria-contaminated carrier. The prepared bacteria-infected carrier is divided into two groups, an experimental group and a control group. The experimental group uses the product obtained in the present invention as a disinfectant, and cleans and disinfects according to the disinfection procedures of the colposcopy machine instruction manual. The control group uses other disinfectants to treat the bacteria. The colposcope machine was cleaned and sterilized (such as conventional disinfectants such as citric acid disinfectant, medical alkaline low-foaming detergent), and the results are shown in Table 5 below:

Table 5 is the kill logarithmic value of the disinfectant solution of the present invention to bacteria

Results: Compared the bactericidal efficacy of the two groups, the logarithmic value of this product against Candida, mold, Staphylococcus and Neisseria gonorrhoeae stained on the PTFE tube was >5.89, and the bactericidal effect was obviously better than that of the control group, indicating that this product It has good sterilization and disinfection effect.

The present invention has been described above with reference to the embodiments of the present invention. However, these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. The scope of the invention is defined by the appended claims and their equivalents. Those skilled in the art can make various substitutions and modifications without departing from the scope of the present invention, and these substitutions and modifications should all fall within the scope of the present invention.

Claims (4)

1. for the preparation method of the disinfectant of cleaning colposcope, it is characterized in that: the steps are as follows: (1) Add chlorhexidine hydrochloride, phenol and salicylic acid into the liquid preparation tank, add trichloroisocyanuric acid after 3-5 minutes, add water after standing for 1.5-2.5 hours, stir at 45-55°C for 0.6 After -0.8 hours, the buffer solution was obtained, and then the temperature of the buffer solution was lowered to -4 to -2°C; (2) Add hydrogen peroxide and peracetic acid dropwise to the buffer solution obtained in step (1), and continue stirring for 0.5-0.8 hours to obtain a disinfectant; (3) Filtrate the disinfectant solution obtained in step (2) through a microporous membrane, and pack it separately; the pore size of the microporous membrane is 0.10-0.45 μm; Gained disinfectant solution for cleaning colposcope, by weight components, peracetic acid 0.8%, hydrogen peroxide 3.0%, chlorhexidine hydrochloride 0.3%, phenol 0.03%, salicylic acid 3.0%, trichloroisocyanuric acid 4.0%, the balance is water. 2. The preparation method according to claim 1, characterized in that: step (1): add trichloroisocyanuric acid after 4 minutes, and add water after standing for 2 hours. 3. The preparation method according to claim 1, characterized in that: step (1): lower the temperature of the buffer solution to -3°C. 4. The preparation method according to claim 1, characterized in that: the pore diameter of the microporous membrane in step (3) is 0.22 μm.