CN104082303A - Bactericidal composition containing cyflufenamid and amides bactericide - Google Patents
Bactericidal composition containing cyflufenamid and amides bactericide Download PDFInfo
- Publication number
- CN104082303A CN104082303A CN201410362664.2A CN201410362664A CN104082303A CN 104082303 A CN104082303 A CN 104082303A CN 201410362664 A CN201410362664 A CN 201410362664A CN 104082303 A CN104082303 A CN 104082303A
- Authority
- CN
- China
- Prior art keywords
- cyflufenamid
- composition
- powdery mildew
- bactericidal
- bactericidal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005755 Cyflufenamid Substances 0.000 title claims abstract description 63
- ACMXQHFNODYQAT-UHFFFAOYSA-N cyflufenamid Chemical compound FC1=CC=C(C(F)(F)F)C(C(NOCC2CC2)=NC(=O)CC=2C=CC=CC=2)=C1F ACMXQHFNODYQAT-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 150000001408 amides Chemical class 0.000 title claims abstract description 49
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 31
- 239000003899 bactericide agent Substances 0.000 title abstract description 6
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- 240000009088 Fragaria x ananassa Species 0.000 claims abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 74
- 241000894006 Bacteria Species 0.000 claims description 73
- 150000001412 amines Chemical class 0.000 claims description 36
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing cyflufenamid and an amides bactericide. The bactericidal composition is prepared from a first active ingredient (cyflufenamid) and a second active ingredient (isopyrazam or fluopyram) with weight ratio of (1:10) to (8:1), and the sum of the contents of the first active ingredient and the second active ingredient is 5-80% of the composition in total weight. The composition can be prepared into a suspending agent, a water dispersible granule, a wettable powder, a dispersed oil suspending agent or an emulsion in water which are allowed agriculturally. The composition has the reasonable formulation and the good bactericidal effect, the activity and the bactericidal effect of the composition are not the easy combination of the activity and the bactericidal effects of all the ingredients, compared with an existing single preparation, the bactericidal composition has the remarkable bactericidal effect and the remarkable synergism and is high in safety to crops, and the bactericidal composition has the remarkable prevention and control effect on powdery mildew of the crops, and has the relatively excellent prevention and control effect on powdery mildew of wheat, cucumbers and strawberries particularly.
Description
Technical field
The invention belongs to technical field of compounded pesticide, relate to a kind of bactericidal composition, this bactericidal composition contains the first active component cyflufenamid and the second active component acid amide fungicides pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides, the powdery mildew that is applicable to prevent and treat crops.
Background technology
Cyflufenamid, English common name cyflufenamid, chemical name: (Z)-N-[α-(ring the third methoxyimino)-2, the fluoro-6-of 3-bis-(trifluoromethyl) benzyl]-2-phenyl acetamide.The phenyl-acetamides series bactericidal agent of cyflufenamid Shi You Tso Tat Co., Ltd., Japan exploitation, there is excellent prevention effect and certain therapeutic activity, also there is blade face infiltration and fumigation action, the feature that resistance of rainwater washing against and lasting period are long, but interior absorption is poor, be mainly used in preventing and treating the powdery mildew in vegetables, fruit tree and various types of grain.Research shows, the mechanism of action of cyflufenamid is to suppress formation and the growth of mitogenetic haustorium on mycelia in the Powdery Mildew history of life (being also pathogenic process), suppresses the growth of secondary hyphae and the formation of hapteron.
Pyrazoles naphthalene bacterium amine, English common name isopyrazam, chemical name: 3-(methyl fluoride)-1-methyl-N-[1,2,3,4-tetrahydrochysene-9-isopropyl-Isosorbide-5-Nitrae-methylene-5-yl]-pyrazole-4-carboxamide.Pyrazoles naphthalene bacterium amine is mitochondrial respiratory inhibitor, and Spores germination, the growth of germ tube and the formation of absorber are had to stronger inhibitory action, fungi is had to the effect that suppresses mycelial growth and sporulation.
Fluorine pyrrole bacterium acid amides, English common name fluopyram, the chloro-5-of chemical name: 2-[3-(trifluoromethyl)-2-pyridine radicals) ethyl]-α, α, the fluoro-O-toluamide of α-tri-.By hindering the electronics transfer of succinate dehydrogenase in respiratory chain, suppress mitochondrial respiratory, by the several stages in inhibition pathogen growth cycle, arrive the object of control pathogen.
Powdery mildew is a kind of worldwide disease of extensive generation.Pathogen is mainly propagated by air-flow, has short incubation period, infects the features such as frequent, popularity is strong, resistance development is fast again, and the crops such as wheat, cucumber, grape, strawberry are caused harm seriously, causes serious economic loss.Prevent and treat at present the medicaments such as the multiplex Tebuconazole of crop powdery mildew, nitrile bacterium azoles, triazolone, Flusilazole, the phonetic phenol of second, kresoxim-methyl, thiophanate-methyl, carbendazim.Because these pesticide active ingredients have been used for many years, germ has produced resistance to these agricultural chemicals, and triazole type medicament is to dicotyledonous crops poor stability, and improper use often causes phytotoxicity accident.Therefore, be badly in need of a kind of agricultural chemicals good, high to crop safety to crop powdery mildew control efficiency of invention.
After cyflufenamid, pyrazoles naphthalene bacterium amine and the listing of fluorine pyrrole bacterium acid amides, there is resistance risk.Actual agricultural chemicals experience shows, alone cyflufenamid, pyrazoles naphthalene bacterium amine and fluorine pyrrole bacterium acid amides control crop powdery mildew, be unfavorable for reducing resistance risk.For reducing Powdery Mildew, cyflufenamid, pyrazoles naphthalene bacterium amine and fluorine pyrrole bacterium acid amides are produced to the danger of resistance, conventionally with the reactive compound of the different mechanisms of action, combine to prevent and treat powdery mildew at present.By literature search, inventor learns that also not having cyflufenamid and pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides to be mixed at present prevents and treats the bibliographical information of crop powdery mildew.
Summary of the invention
The object of the present invention is to provide a kind of bactericidal composition containing cyflufenamid and acid amide fungicides, cyflufenamid is the first active component, and acid amide fungicides is the second active component, and described acid amide fungicides refers to pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides.Inventor finds by test, the different cyflufenamid of the mechanism of action and pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides is composite, there is obvious synergistic effect, can significantly improve control efficiency to crop powdery mildew, reduce dosage, reduce cost accounting, high to crop safety.
Another object of the present invention is to provide the bactericidal composition preparation formulation containing cyflufenamid and pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides.
A further object of the present invention is to provide the application of above-mentioned composition on control crop powdery mildew.
In order to overcome the defect of existing unitary agent, in above-mentioned bactericidal composition, the weight ratio of the first active component cyflufenamid and the second active component pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides is 1:10～8:1.
According to the physicochemical property between component and practical application, the content sum of the first active component and the second active component is 5%～80% of described bactericidal composition gross weight.
Bactericidal composition containing cyflufenamid and acid amide fungicides of the present invention, the preparation formulation that can prepare according to method known in those skilled in the art can be for suspending agent, water dispersible granules, wetting powder, dispersible oil-suspending agent or aqueous emulsion.In preparation during above-mentioned formulation, the different pesticidal preparations auxiliary element (auxiliary agent) of choice for use as required.Described auxiliary element is one or more in dispersion medium, dispersant, emulsifier, wetting agent, thickener, defoamer, antifreezing agent, disintegrant, binding agent, filler.
To suspending agent, spendable auxiliary agent has: dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), TERSPERSE2020 (U.S. Huntsman Corporation produces, alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this dish-60# (common name: Span60), Tween-60 # (common name: polyoxyethylene sorbitan stearate), agriculture breast 1601# (common name: one or more triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), in TERSPERSE4894 (U.S. Huntsman Corporation product) emulsifier is as Nongru-700 # (common name:; Wetting agent as in alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE2500 (U.S. Huntsman Corporation product) one or more; Thickener as in xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate one or more; Preservative as in formaldehyde, benzoic acid, Sodium Benzoate one or more; Stabilizing agent as in epoxidized soybean oil, epoxychloropropane, triphenyl phosphate one or more; Defoamer is as organic silicon defoamer; Antifreezing agent as ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more; Water is deionized water.
For water dispersible granules, those skilled in the art are familiar with the corresponding auxiliary agent of use and complete the present invention very much.Dispersant as in polycarboxylate (TERSPERSE2700, T36, GY-D06 etc.), lignosulfonates, alkylnaphthalene sulfonate one or more; Wetting agent as in alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more; Disintegrant as in ammonium sulfate, sodium sulphate, polyvinylpyrrolidone, starch and derivative thereof, bentonite one or more; Binding agent is as one or more in starch, glucose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, sucrose; Filler as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: dispersant is as polycarboxylic acid salt (TERSPERSE2700, T36, GY-D06 etc.), lignin sulfonate (Ufoxane3A, Borresperse NA, Borresperse CA-SA etc.), naphthalene and Fluhyzon formaldehyde condensation products Sulfonates (NNO, MF, Morwet D-425, Tamol NN, TERSPERSE2020 etc.), Nekal BX (nekal), EO-PO block polyether class, alkylphenol-polyethenoxy base ether phosphate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate (SOPA), in one or more; Wetting agent as in Sulfates (K-12), Sulfonates (ABS-Na, BX, Terwet1004 etc.), compound wetting agent (Morwet EFW) one or more; Filler as diatomite, kaolin, fine particle calcium carbonate, talcum powder, white carbon, attapulgite, potter's clay, ammonium sulfate, urea, sucrose, glucose, corn starch, sodium sulphate, sodium polyphosphate etc. one or more.
To dispersibling oil-suspending agent, spendable auxiliary agent has: dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), TERSPERSE2020 (HUNTSMAN of U.S. Huntsman Corporation produces, alkyl naphthalene sulfonic acid salt) one or more, emulsifier emulsifier (BY-110 as serial in BY (castor oil polyoxyethylene ether), BY-125, BY-140), Nongru-700 # (common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this dish-60# (common name: sorbitan monostearate), Tween-60 # (common name: sorbitan monostearate APEO), agriculture breast 1601# (common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), one or more in TERSPERSE4894 (U.S. Huntsman Corporation product), wetting agent as in alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol polyoxyethylene phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE2500 (U.S. Huntsman Corporation product) one or more, thickener as in white carbon, polyvinyl alcohol, bentonite, aluminium-magnesium silicate one or more, antifreezing agent as ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more, dispersion medium as in soybean oil, rapeseed oil, corn oil, methyl oleate, diesel oil, machine oil, mineral oil one or more.
To aqueous emulsion, spendable auxiliary agent has: emulsifier is as Nonyl pheno (EO=10) ether phosphate, triphen ethyl-phenol polyoxyethylene ether phosphate, Nongru-700 # (common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201#, this dish-60# (common name: Span60), Tween-60 # (common name: polyoxyethylene sorbitan stearate), TX-10 (common name: octyl phenol polyoxy ethene (10) ether), agriculture breast 1601 (common name: triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), agriculture breast 600#, in agriculture breast 400# one or more, solvent as dimethylbenzene, toluene, cyclohexanone, solvent naphtha (trade mark: S-150, S-180, S-200) one or more, stabilizing agent as in triphenyl phosphite, epoxychloropropane, epoxidized soybean oil one or more, antifreezing agent: ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more, thickener as in xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate one or more, preservative as in formaldehyde, benzoic acid, Sodium Benzoate one or more, water is deionized water.
The application of above-mentioned composition on control crop powdery mildew, as preferably, contains the application of the composite composition of cyflufenamid and acid amide fungicides pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides on control wheat powdery mildew, powdery mildew of cucumber, powdery mildew of strawberry.
The first active component cyflufenamid and the second active component pyrazoles naphthalene bacterium amine or the composite synergistic effect that shows as of fluorine pyrrole bacterium acid amides in composition of the present invention, the activity of said composition and bactericidal effect are not the simple superposition of each composition activity, but have significant synergistic effect.In addition, the advantage of described bactericidal composition also shows that component is reasonable, has treatment and protective effect concurrently, and bactericidal effect is good, and drug cost is low, good to crop safety, meets the security requirement of pesticidal preparations.Aspect drug effect, said composition has good control efficiency to crop powdery mildew.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention, all any modifications of making within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
(1) preparation is prepared part
First the first active component cyflufenamid and the second active component pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides complex preparation are described.The processing technology of the various preparations of the present composition is prior art, according to different situations, can change to some extent.It should be noted that, the percentage in following embodiment ownership agent prescription is all weight percentage.
FORMULATION EXAMPLE 1
Take 6% cyflufenamid, 12% pyrazoles naphthalene bacterium amine, 3%TERSPERSE4894 (U.S. Huntsman Corporation product), 3%TERSPERSE2500 (U.S. Huntsman Corporation product), 2%TERSPERSE2020 (U.S. Huntsman Corporation product), 2% aluminium-magnesium silicate, 0.2% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry product company produces), surplus is deionized water.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making active ingredient after sand mill sand milling, is 18% cyflufenamid pyrazoles naphthalene bacterium amine suspending agent.
FORMULATION EXAMPLE 2
Take 10% cyflufenamid, 20% fluorine pyrrole bacterium acid amides, 3%TERSPERSE4894 (U.S. Huntsman Corporation product), 2%TERSPERSE2500 (U.S. Huntsman Corporation product), 2% dispersing agent NNO, 2% bentonite, 0.2% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry product company produces), deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making active ingredient after sand mill sand milling, is 30% cyflufenamid fluorine pyrrole bacterium acid amides suspending agent.
FORMULATION EXAMPLE 3
Take 5% cyflufenamid, 25% pyrazoles naphthalene bacterium amine, 2%TERSPERSE2700 (polycarboxylate, U.S. Huntsman Corporation produces), 3% sodium lignin sulfonate, 1% Nekal BX (nekal), 1%K-12 (lauryl sodium sulfate), 2%PVA (molecular weight 2000), 2% polyvinylpyrrolidone, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule mixes, to produce active ingredient be 30% cyflufenamid pyrazoles naphthalene bacterium amine water dispersible granules for ultra micro air-flow crushing, mixing, granulation step.
FORMULATION EXAMPLE 4
Take 10% cyflufenamid, 70% fluorine pyrrole bacterium acid amides, 2%T36 (polycarboxylate), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), attapulgite and add to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule mixes, to produce active ingredient be 80% cyflufenamid fluorine pyrrole bacterium acid amides water dispersible granules for ultra micro air-flow crushing, mixing, granulation step.
FORMULATION EXAMPLE 5
Take 5% cyflufenamid, 50% pyrazoles naphthalene bacterium amine, 4% calcium lignosulfonate (Ufoxane3A), 4% alkylnaphthalene sulfonate formaldehyde condensation products (Tamol NN), 1% lauryl sodium sulfate, 8% white carbon, kaolin and fill up the weight portion to 100%.It is 55% cyflufenamid pyrazoles naphthalene bacterium amine wetting powder that above-mentioned raw materials is prepared into active ingredient through mixing, ultra micro air-flow crushing, hybrid technique step.
FORMULATION EXAMPLE 6
Take 10% cyflufenamid, 30% fluorine pyrrole bacterium acid amides, 6% calcium lignosulfonate, 4% alkylnaphthalene sulfonate formaldehyde condensation products (Morwet D-425), 2% lauryl sodium sulfate, white carbon and fill up the weight portion to 100%.It is 40% cyflufenamid fluorine pyrrole bacterium acid amides wetting powder that above-mentioned raw materials is prepared into active ingredient through mixing, ultra micro air-flow crushing, hybrid technique step.
FORMULATION EXAMPLE 7
Take 20% cyflufenamid, 10% pyrazoles naphthalene bacterium amine, 3%TERSPERSE2020 (U.S. Huntsman Corporation product), 3% this dish-60#, 4% Tween-60 #, 4% agriculture breast 2201#, 3% Nongru-700 #, 1%TERSPERSE2500 (U.S. Huntsman Corporation product), 2% white carbon, 5% propane diols, methyl oleate adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making active ingredient after sand mill sand milling, is that 30% cyflufenamid pyrazoles naphthalene bacterium amine dispersibles oil-suspending agent.
FORMULATION EXAMPLE 8
Take 24% cyflufenamid, 3% fluorine pyrrole bacterium acid amides, 2% dispersing agent NNO, 3% this dish-60#, 8%BY-110,1%TERSPERSE2500 (U.S. Huntsman Corporation product), 1% aluminium-magnesium silicate, 3% glycerine, soybean oil and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making active ingredient after sand mill sand milling, is that 27% cyflufenamid fluorine pyrrole bacterium acid amides dispersibles oil-suspending agent.
FORMULATION EXAMPLE 9
Take 10% cyflufenamid, 10% pyrazoles naphthalene bacterium amine, 8% agriculture breast 2201#, 2% Nonyl pheno (EO=10) ether phosphate, 4% triphen ethyl-phenol polyoxyethylene ether phosphate, 2% this dish-60#, 1% epoxychloropropane, 2% ethylene glycol, 5% dimethylbenzene, 0.2% xanthans, 0.5% benzoic acid, surplus is deionized water.Above-mentioned raw materials is through mixing, and it is 20% cyflufenamid pyrazoles naphthalene bacterium amine aqueous emulsion that high speed shear emulsification makes active ingredient.
FORMULATION EXAMPLE 10
Take 2% cyflufenamid, 3% fluorine pyrrole bacterium acid amides, 3% agriculture breast 2201#, 2% Nonyl pheno (EO=10) ether phosphate, 2% Tween-60 #, 2% this dish-60#, 5% propane diols, 10% solvent naphtha S-180,5% cyclohexanone, 0.2% xanthans, 0.5% benzoic acid, surplus is deionized water.Above-mentioned raw materials is through mixing, and it is 5% cyflufenamid fluorine pyrrole bacterium acid amides aqueous emulsion that high speed shear emulsification makes active ingredient.
(2) biologicall test part
Biologicall test embodiment 1
The composite test of the toxicity test to wheat powdery mildew of cyflufenamid and pyrazoles naphthalene bacterium amine (or fluorine pyrrole bacterium acid amides).
Subjects is wheat powdery mildew (Erysiphe graminis).Former medicine is mixed with to the test medicine needing, test method is with reference to < < People's Republic of China's agricultural industry criteria NY/T1156.4-2006 farm-chemical indoor determination test rule bactericide the 4th part: control wheat powdery mildew test pot-culture method > >.First single dose and each Mixed Pharmacy are arranged to 5 variable concentrations gradients (preventive effect is set by geometric progression in 5%～90% scope).Select susceptible wheat breed potted plant, treat that seedling grew to for 2 leaf～3 leaf phases standby.The fresh spore of Powdery Mildew producing in 24h on morbidity wheat leaf blade is evenly shaken off to be inoculated on 2 potted plant wheat seedlings of leaf phase～3 leaf phase of processing.Every processing is no less than 3 basins, every basin 10 strains.After inoculation 24h, by spray-on process, medicament is evenly sprayed on standby wheat seedling, then puts under suitable condition and cultivate.When fully fall ill all blades of the every basin wheat seedling of " Invest, Then Investigate " of contrast wheat seedling, adopt following stage division:
0 grade: anosis;
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for 6%～15% of one-piece blade area;
5 grades: lesion area accounts for 16%～25% of one-piece blade area;
7 grades: lesion area accounts for 26%～50% of one-piece blade area;
9 grades: lesion area accounts for the more than 50% of one-piece blade area.
Computational methods:
Disease index=[∑ (the sick number of sheets * relative level numerical value at different levels)/(investigation total leaf number * 9)] * 100
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
By the linear regression analysis between the probit value of preventive effect and the logarithm value of series concentration, obtain the EC50 value of each medicament, by the abundant method of Sun Yun, calculate the co-toxicity coefficient (CTC) of mixture, with this, evaluate the activity of reagent agent to germ.
The co-toxicity coefficient of complex preparation (CTC) >=120 shows as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.
Table 1-1 cyflufenamid and the composite Toxicity Determination to wheat powdery mildew of pyrazoles naphthalene bacterium amine
| Chemicals treatment | Virulence regression equation | Correlation coefficient | EC50 | Co-toxicity coefficient |
| ? | ? | (r) | (mg/L) | (CTC) |
| Cyflufenamid (A) | Y＝5.4317+7.1449X | 0.9961 | 0.87 | - |
| Pyrazoles naphthalene bacterium amine (B) | Y＝2.2782+3.8850X | 0.9948 | 5.02 | - |
| A:B＝1:10 | Y＝3.6485+3.1152X | 0.9982 | 2.72 | 128.9 |
| A:B＝1:5 | Y＝4.0528+3.1005X | 0.9808 | 2.02 | 138.4 |
| A:B＝1:2 | Y＝4.7113+3.0766X | 0.9971 | 1.24 | 156.2 |
| A:B＝1:1 | Y＝5.0057+3.6579X | 0.9840 | 1.00 | 148.8 |
| A:B＝2:1 | Y＝5.2564+3.7203X | 0.9771 | 0.85 | 140.8 |
| A:B＝5:1 | Y＝5.3286+2.9751X | 0.9818 | 0.78 | 130.1 |
| A:B＝8:1 | Y＝3.3864+2.7999X | 0.9965 | 0.73 | 131.6 |
Table 1-2 cyflufenamid and the composite Toxicity Determination to wheat powdery mildew of fluorine pyrrole bacterium acid amides
Toxicity Determination result shows: cyflufenamid be take weight ratio, and ﹕ 10～8 ﹕ 1 are mixed that wheat powdery mildew is had to good virulence as 1 with pyrazoles naphthalene bacterium amine (or fluorine pyrrole bacterium acid amides), all have good synergistic effect.
Biologicall test embodiment 2
The composite test of the toxicity test to powdery mildew of cucumber of cyflufenamid and pyrazoles naphthalene bacterium amine (or fluorine pyrrole bacterium acid amides).
Subjects is powdery mildew of cucumber bacterium sphaerotheca fuliginea.Former medicine is mixed with to the test medicine needing, test method is with reference to < < People's Republic of China's agricultural industry criteria NY/T1156.11-2008 farm-chemical indoor determination test rule bactericide the 11st part: control cucurbits powdery mildew test pot-culture method > >.First single dose and each Mixed Pharmacy are arranged to 5 variable concentrations gradients (preventive effect is set by geometric progression in 5%～90% scope).With the pure water that is added with a small amount of surfactant (Tween 80), wash and get the fresh spore covering with on Powdery Mildew cucumber leaves, with double gauze, filter, make the suspension that spore concentration is 1 * 105 spore/milliliter, standby.Every processing 3 basins, repeat for 4 times, and only establish the processing that does not contain active ingredient containing solvent and surfactant and do not make blank.With spore suspension 24h inoculation before chemicals treatment, liquid is evenly sprayed in blade face to all wetting, standby after liquid natural air drying.Potted plant cucumber natural air drying after inoculation and chemicals treatment, then moves to thermostatic chamber, under the condition of 20 ℃～24 ℃ of temperature, cultivates 7 days～10 days.Until the sick leaf rate of blank, reach 80% when above, classification investigation is managed incidence everywhere, and 30 leaves are at least investigated in every processing, and grade scale is:
0 grade: anosis;
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for 6%～15% of one-piece blade area;
5 grades: lesion area accounts for 16%～25% of one-piece blade area;
7 grades: lesion area accounts for 26%～50% of one-piece blade area;
9 grades: lesion area accounts for 50%～75% of one-piece blade area;
11 grades: lesion area accounts for the more than 75% of one-piece blade area.
Computational methods:
Disease index=[∑ (the sick number of sheets * relative level numerical value at different levels)/(investigation total leaf number * 11)] * 100
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
By the linear regression analysis between the probit value of preventive effect and the logarithm value of series concentration, obtain the EC50 value of each medicament, by the abundant method of Sun Yun, calculate the co-toxicity coefficient (CTC) of mixture, with this, evaluate the activity of reagent agent to germ.
The co-toxicity coefficient of complex preparation (CTC) >=120 shows as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.
Table 2-1 cyflufenamid and the composite Toxicity Determination to powdery mildew of cucumber of pyrazoles naphthalene bacterium amine
Table 2-2 cyflufenamid and the Toxicity Determination of fluorine pyrrole bacterium acid amides combination to powdery mildew of cucumber
Toxicity Determination result shows: cyflufenamid be take weight ratio, and ﹕ 10～8 ﹕ 1 are mixed that powdery mildew of cucumber bacterium is had to good virulence as 1 with pyrazoles naphthalene bacterium amine (or fluorine pyrrole bacterium acid amides), all have good synergistic effect.
Biologicall test embodiment 3
Control powdery mildew of strawberry field trial
2014 Zhouzhi County, Nian Shaanxi Province have carried out FORMULATION EXAMPLE 1 (18% cyflufenamid pyrazoles naphthalene bacterium amine suspending agent), FORMULATION EXAMPLE 2 (30% cyflufenamid fluorine pyrrole bacterium acid amides suspending agent) control powdery mildew of strawberry field trial, verify that this medicament is to the control efficiency of powdery mildew of strawberry, effective dose and the safety to strawberry.Test method is with reference to < < GB/T17980.119-2004 pesticide field efficacy medicine test criterion (two) bactericidal agent for preventing and treating powdery mildew of strawberry test of pesticide effectiveness > >.Trial crops is strawberry, and controlling object is powdery mildew (Sphaerotheca macularis).In the greenhouse strawberry base of planting more than 3 years continuously, carry out.Test medicine and dosage are for referring to table 3.Separately establish blank, every processing repeats for 4 times, every community 20m
2, Gong32Ge community, random district group is arranged.Adopt conventional spray-on process, mu dispenser liquid 45kg, evenly sprays complete stool.The 1st dispenser is at Strawberry Seedlings powdery mildew their early stage, and medication for the second time after 7 days, is total to dispenser 2 times.
Investigation and statistical method:
7 days and 7 days investigation blade incidences after medicine for the second time after medicine for the first time.5 samplings of every community diagonal, every some investigation 3 strains.Whole blades are investigated in every strain.
Stage division:
0 grade: without scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for 6%～15% of whole leaf area;
5 grades: lesion area accounts for 16%～25% of whole leaf area
7 grades: lesion area accounts for 26%～50% of whole leaf area;
9 grades: lesion area accounts for the more than 50% of whole leaf area.
According to disease, refer to calculate preventive effect.After each medicine, after visual observations dispenser, strawberry growth, leaf look etc. are affected to situation, the safety of examination medicament to strawberry.
Disease index=[∑ (the sick number of sheets * relative level numerical value at different levels)/(investigation total leaf number * 9)] * 100
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
Table 3 control powdery mildew of strawberry field test results
Field test results shows: 18% cyflufenamid pyrazoles naphthalene bacterium amine suspending agent, 30% cyflufenamid fluorine pyrrole bacterium acid amides suspending agent has good control efficiency to powdery mildew of strawberry, dilute respectively 1500 times, 2000 times and 2500 times, 3000 times of sprayings, to powdery mildew of strawberry for the first time after medicine the preventive effect of 7 days be 85.05%, 80.30% and 88.45%, 81.92%, after medicine, the preventive effect of 7 days is 93.10% for the second time, 88.36% and 93.24%, 89.34%, obviously be better than 1000 times of 10% cyflufenamid suspending agents, 20% 1000 times of pyrazoles naphthalene bacterium amine suspending agents, the preventive effect of 20% 1000 times of fluorine pyrrole bacterium acid amides suspending agents.
Under this experimental condition, 1 day to 7 days visual observations reagent agent safety to strawberry after each medicine, result shows, these several medicaments all produce without poisoning From Strawberry Leaves, petiole and flowers and fruits, performance safety.
Result of the test shows cyflufenamid and pyrazoles naphthalene bacterium amine (or the fluorine pyrrole bacterium acid amides) use that is mixed by a certain percentage, has obviously improved the control efficiency to powdery mildew of strawberry, has reduced dosage, to strawberry growth safety, is the desirable medicament of control powdery mildew of strawberry.
In sum, composition of the present invention is to adopt two kinds of active components composite, its activity and bactericidal effect are not the simple superposition of each composition activity, compare with existing unitary agent, except having significant bactericidal effect, and have significant synergistic effect, and good to crop safety, meet the security requirement of pesticidal preparations.
Claims (5)
1. the bactericidal composition containing cyflufenamid and acid amide fungicides, it is characterized in that, active ingredient is comprised of the first active component cyflufenamid and the second active component acid amide fungicides pyrazoles naphthalene bacterium amine or fluorine pyrrole bacterium acid amides, and the weight ratio of the first active component and the second active component is 1:10～8:1.
2. according to claim 1 containing the bactericidal composition of cyflufenamid and acid amide fungicides, it is characterized in that, the content sum of described the first active component and the second active component is described composition total weight 5%～80%.
3. according to claim 1 containing the bactericidal composition of cyflufenamid and acid amide fungicides, the formulation of described composition is suspending agent, water dispersible granules, wetting powder, dispersible oil-suspending agent or aqueous emulsion.
4. according to the application on control crop powdery mildew containing the bactericidal composition of cyflufenamid and acid amide fungicides described in any one in claims 1 to 3.
5. contain according to claim 4 the bactericidal composition of cyflufenamid and acid amide fungicides in the application preventing and treating on wheat powdery mildew, powdery mildew of cucumber, powdery mildew of strawberry.
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| CN105746525A (en) * | 2016-04-26 | 2016-07-13 | 南京华洲药业有限公司 | Fungicidal composition containing isopyrazam and mepanipyrim and application thereof |
| CN107258796A (en) * | 2017-06-21 | 2017-10-20 | 天峨县平昌生态农业有限公司 | A kind of bactericidal composition available for controlling powdery mildew |
| CN109566626A (en) * | 2017-09-29 | 2019-04-05 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
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| CN102448307A (en) * | 2009-05-27 | 2012-05-09 | 拜尔农作物科学股份公司 | Use of succinate dehydrogenase inhibitors for increasing the resistance of plants or plant parts to abiotic stress |
| CN103070174A (en) * | 2013-01-22 | 2013-05-01 | 海利尔药业集团股份有限公司 | Bactericidal composition containing fluopicolide and cyflufenamid |
| CN103190421A (en) * | 2013-04-07 | 2013-07-10 | 海南正业中农高科股份有限公司 | Cyflufenamid-containing sterilizing composite |
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| CN102448307A (en) * | 2009-05-27 | 2012-05-09 | 拜尔农作物科学股份公司 | Use of succinate dehydrogenase inhibitors for increasing the resistance of plants or plant parts to abiotic stress |
| CN103070174A (en) * | 2013-01-22 | 2013-05-01 | 海利尔药业集团股份有限公司 | Bactericidal composition containing fluopicolide and cyflufenamid |
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| CN105746525A (en) * | 2016-04-26 | 2016-07-13 | 南京华洲药业有限公司 | Fungicidal composition containing isopyrazam and mepanipyrim and application thereof |
| CN107258796A (en) * | 2017-06-21 | 2017-10-20 | 天峨县平昌生态农业有限公司 | A kind of bactericidal composition available for controlling powdery mildew |
| CN109566626A (en) * | 2017-09-29 | 2019-04-05 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
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