CN104069127A - 含电解质平衡盐和新洁尔灭的组合物及制备方法 - Google Patents
含电解质平衡盐和新洁尔灭的组合物及制备方法 Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 150000003839 salts Chemical class 0.000 title abstract description 12
- 238000002360 preparation method Methods 0.000 title description 10
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 159000000003 magnesium salts Chemical class 0.000 claims abstract description 5
- 230000018044 dehydration Effects 0.000 claims abstract description 4
- 238000006297 dehydration reaction Methods 0.000 claims abstract description 4
- 239000013589 supplement Substances 0.000 claims abstract description 4
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 27
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 22
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 20
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- 125000001246 bromo group Chemical group Br* 0.000 claims description 19
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 11
- 239000001103 potassium chloride Substances 0.000 claims description 11
- 235000011164 potassium chloride Nutrition 0.000 claims description 11
- 239000001632 sodium acetate Substances 0.000 claims description 11
- 235000017281 sodium acetate Nutrition 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 11
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 10
- 239000001509 sodium citrate Substances 0.000 claims description 7
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 7
- MSXHSNHNTORCAW-GGLLEASOSA-M sodium;(2s,3s,4s,5r,6s)-3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].O[C@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O MSXHSNHNTORCAW-GGLLEASOSA-M 0.000 claims description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 6
- 239000001110 calcium chloride Substances 0.000 claims description 6
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims description 4
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
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- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 2
- 235000019800 disodium phosphate Nutrition 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 239000001540 sodium lactate Substances 0.000 claims description 2
- 235000011088 sodium lactate Nutrition 0.000 claims description 2
- 229940005581 sodium lactate Drugs 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- 235000011008 sodium phosphates Nutrition 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 1
- 239000008151 electrolyte solution Substances 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 abstract description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract description 2
- 239000011575 calcium Substances 0.000 abstract description 2
- 229910052791 calcium Inorganic materials 0.000 abstract description 2
- 239000011591 potassium Substances 0.000 abstract description 2
- 229910052700 potassium Inorganic materials 0.000 abstract description 2
- 239000011734 sodium Substances 0.000 abstract description 2
- 229910052708 sodium Inorganic materials 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000008213 purified water Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
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- 230000002421 anti-septic effect Effects 0.000 description 2
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- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 206010011469 Crying Diseases 0.000 description 1
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- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种含电解质平衡盐和新洁尔灭的消毒液组合物，技术特征在于在新洁尔灭溶液中添加了含有钠、钾、钙、镁盐或以上其中的任意组合的电解质，用于人体局部细菌感染。在消毒抑菌的同时，补充电解质平衡盐，防止脱水，快速恢复正常生理功能。
Description
技术领域
本发明涉及一种含有电解质的平衡盐和新洁尔灭的消毒剂组合物。
背景技术
新洁尔灭又称苯扎溴铵,属季铵盐类阳离子表面活性消毒剂,具有性质稳定、渗透力强、刺激性小、毒性低、具较强的杀菌效力等特性,广泛应用于皮肤、粘膜和术区的消毒。
新洁尔灭溶液为无色或淡黄色的澄明液体；芳香，味极苦。能改变细菌胞浆膜通透性，使菌体胞浆物质外渗，阻碍其代谢而起杀灭作用。对革兰阳性细菌作用较强，新洁尔灭水溶液用于局部皮肤及粘膜消毒；创面及阴道冲洗。低浓度有抑菌作用，高浓度则有杀菌作用。
皮肤损伤后创面组织出现炎性反应，局部毛细血管扩张，管壁渗透性增加，血浆中白细胞及抗体等多种成分渗出，一方面要及时经消毒处理，防止造成创面感染。另一方面由于电解质平衡受到破坏，易造成电解质的丢失以及细胞脱水，严重时可致休克，所以应急需补充电解质平衡盐。
发明内容
本发明提供一种含有电解质的平衡盐和新洁尔灭的消毒剂组合物，以克服现有新洁尔灭溶液的不足，在消毒抑菌的同时，补充电解质平衡盐，防止脱水，快速恢复正常生理功能。
本发明的技术特征在于在新洁尔灭溶液中添加了含有钠、钾、钙、镁盐或以上其中的任意组合的电解质，用于防止电解质的流失。
新洁尔灭可选用新洁尔灭或洁尔灭或以上其中的任意组合，优选新洁尔灭。优选浓度为0.01-3%（W/V）。
电解质钠盐为氯化钠或磷酸钠或磷酸二氢钠或磷酸氢二钠或醋酸钠或乳酸钠或葡萄糖酸钠或枸橼酸钠或以上其中的任意组合。优选氯化钠或醋酸钠或葡萄糖酸钠或枸橼酸钠或以上其中的任意组合。优选浓度为0.1-5%（W/V）。
电解质钾盐为氯化钾或磷酸二氢钾或磷酸氢二钾或以上其中的任意组合。优选氯化钾或磷酸二氢钾或两者的任意组合。优选浓度为0.01-2%（W/V）。
电解质钙盐为氯化钙或碳酸钙或两者的任意组合。优选浓度为0.01-2%（W/V）。
电解质镁盐为氯化镁或硫酸镁或两者的任意组合。优选浓度为0.01-2%（W/V）。
具体实施方式
以下实施例仅对本发明进行进一步的说明，不应理解为对本发明进一步的限制。
实施例1 含有电解质平衡盐和新洁尔灭的消毒剂制备
取纯化水1000ml，加入新洁尔灭0.1g,充分搅拌使溶解，依次加入氯化钠5.26g,醋酸钠3.68g,葡萄糖酸钠5.02g，氯化钾0.37g与氯化镁0.30g, 充分搅拌使溶解。
实施例2 含有电解质平衡盐和洁尔灭的消毒剂制备
取纯化水1000ml，加入洁尔灭0.1g,充分搅拌使溶解，依次加入氯化钠5.26g,醋酸钠3.68g,葡萄糖酸钠5.02g，氯化钾0.37g与氯化镁0.30g, 充分搅拌使溶解。
实施例3 含有电解质平衡盐和新洁尔灭的消毒剂制备
取纯化水1000ml，加入新洁尔灭0.1g，充分搅拌使溶解，依次加入氯化钠6.40g,醋酸钠3.90g,柠檬酸钠1.70g，氯化钾0.75g，氯化钙0.48g与氯化镁0.30g, 充分搅拌使溶解。
实施例4 含有电解质平衡盐和洁尔灭的消毒剂制备
取纯化水1000ml，加入洁尔灭0.1g，充分搅拌使溶解，依次加入氯化钠6.40g,醋酸钠3.90g,柠檬酸钠1.70g，氯化钾0.75g，氯化钙0.48g与氯化镁0.30g, 充分搅拌使溶解。
实施例5 含有电解质平衡盐和新洁尔灭的消毒剂制备
取纯化水1000ml，加入新洁尔灭0.5g，充分搅拌使溶解，依次加入氯化钠6.40g,醋酸钠3.90g,柠檬酸钠1.70g，氯化钾0.75g，氯化钙0.48g与氯化镁0.30g, 充分搅拌使溶解。
实施例6 含有电解质平衡盐和新洁尔灭的消毒剂制备
取纯化水1000ml，加入新洁尔灭0.5g,充分搅拌使溶解，依次加入氯化钠5.26g,醋酸钠3.68g,葡萄糖酸钠5.02g，氯化钾0.37g与氯化镁0.30g, 充分搅拌使溶解。
实施例7 含有电解质平衡盐和洁尔灭的消毒剂制备
取纯化水1000ml，加入洁尔灭0.5g，充分搅拌使溶解，依次加入氯化钠6.40g,醋酸钠3.90g,柠檬酸钠1.70g，氯化钾0.75g，氯化钙0.48g与氯化镁0.30g, 充分搅拌使溶解。
实施例8 含有电解质平衡盐和洁尔灭的消毒剂制备
取纯化水1000ml，加入洁尔灭0.5g,充分搅拌使溶解，依次加入氯化钠5.26g,醋酸钠3.68g,葡萄糖酸钠5.02g，氯化钾0.37g与氯化镁0.30g, 充分搅拌使溶解。
Claims (8)
1.一种消毒液组合物，该组合物含有：
0.01-3%（W/V）新洁尔灭或洁尔灭和
0.01-15%（W/V）电解质溶液。
2.权利要求1所述组合物，该组合物含有：
0.01-1%（W/V）新洁尔灭或洁尔灭和
0.1-5%（W/V）钠盐、
0.01-2%（W/V）钾盐、
0.01-2%（W/V）钙盐、
0.01-2%（W/V）镁盐、
或上述钠盐、钾盐、钙盐、镁盐的任意组合。
3.权利要求1或2所述组合物，该组合物含有新洁尔灭或洁尔灭或两者的任意组合。
4.权利要求1或2所述组合物，该组合物含有氯化钠或磷酸钠或磷酸二氢钠或磷酸氢二钠或醋酸钠或乳酸钠或葡萄糖酸钠或枸橼酸钠或以上其中的任意组合。
5.权利要求1或2所述组合物，该组合物含有氯化钾或磷酸二氢钾或磷酸氢二钾或以上其中的任意组合。
6.权利要求1或2所述组合物，该组合物含有氯化钙或碳酸钙或两者的任意组合。
7.权利要求1或2所述组合物，该组合物含有氯化镁或硫酸镁或两者的任意组合。
8.权利要求1或2所述组合物，可用于创面、皮肤、粘膜、腔道的消毒，在消毒抑菌的同时，补充电解质平衡盐，防止脱水，快速恢复正常生理功能。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860891A (zh) * | 2017-03-01 | 2017-06-20 | 成都正康药业有限公司 | 一种苯扎溴铵氯化钠冲洗液及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001017472A1 (en) * | 1999-09-08 | 2001-03-15 | Watson Pharmaceuticals, Inc. | Using quaternary ammonium salts for transdermal drug delivery |
| CN103202826A (zh) * | 2013-04-18 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | 一种苯扎氯铵与碳酸氢钠复合消毒液 |
-
2014
- 2014-06-24 CN CN201410284959.2A patent/CN104069127A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001017472A1 (en) * | 1999-09-08 | 2001-03-15 | Watson Pharmaceuticals, Inc. | Using quaternary ammonium salts for transdermal drug delivery |
| CN103202826A (zh) * | 2013-04-18 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | 一种苯扎氯铵与碳酸氢钠复合消毒液 |
Non-Patent Citations (1)
| Title |
|---|
| 迟乾钲: "防止0.1%新洁尔灭溶液乳浊的探讨", 《山东医药》, no. 06, 31 December 1983 (1983-12-31) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860891A (zh) * | 2017-03-01 | 2017-06-20 | 成都正康药业有限公司 | 一种苯扎溴铵氯化钠冲洗液及其制备方法 |
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