CN104042881B - For regulating the compositions of ovarian function - Google Patents
For regulating the compositions of ovarian function Download PDFInfo
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Abstract
A kind of compositions for regulating ovarian function, with Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be as ministerial drug.In conjunction with the feature in female patient all ages and classes stage, according to the weight of the state of an illness, ovarian hypofunction is divided into deficiency of kidney-QI, deficiency of the kidney yin interior-heat, and the hepatic and renal YIN deficiency, the three phases such as disarmony between the heart and kidney.Clinic can be selected application again according to the weight of the age of patient or the state of an illness to medical material.The various compositionss that the present invention provides are from the viewpoint of " vital experiences ", physiological and pathological feature for all ages and classes women, principle with determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, sum up " woman 30 ", " woman 40 ", the conditioning prescription that " woman 50 " are suitable for, to adjust the ovarian function of these three different age group women, thus improve the ovarian function of patient, improve the quality of living.
Description
Technical field
The present invention relates to a kind of compositions for regulating woman organ function, particularly relate to a kind of its by several kinds of Chinese medicinal materials
By monarch, minister, help, make compatible compositions, it is adaptable to ovarian function is adjusted, thus improves the ovarian function of patient,
Improve fertility and quality of life.
Background technology
Ovarian hypofunction i.e. diminished ovarian reserve function, refers to the reduced capability of ovarian follicular growth, oocyte quality
Decline, thus cause the decline of fertility.By in the traditional Chinese medical science, through theory, " seven years old kidney qi of woman is contained, and dental transition is sent out long: two or seven menses
Extremely, conception vessel leads to, and taichong channel is contained, regular menstrual cycle, therefore has son；Radix Notoginseng kidney qi is the most flat, therefore growth of wisdom tooth and mature development of the body；Four or seven strong muscle and bones,
Tooth length pole, sturdy body；Five or seven yangming meridians decline, the face becoming withered, send out the beginning and fall；673 YANG pulse decline in upper, wrinkly face, send out and begin in vain；Seven
Seven conception vessels are empty, and taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, menopause, therefore senile appearance and loss of fecundity are also." this section of literature record prompting woman 14 years old
Menstrual onset, begins with facial pigmentation for 35 years old, and hair is easy to fall off waits evidence for senescence, menopause in about 49 years old.
Chinese invention patent ZL02110299.6 discloses a kind of health-care nutrient capsule and preparation method thereof and application, belongs to medicine
Compositions, its by 1～5 part of succinum, 1～5 part of Margarita, 0～5 part of Os Draconis or Concha Ostreae, 2～4 parts of Semen Ziziphi Spinosaes, 0～5 part of Semen Platycladi, 2
～4 portions of Ganodermas or Caulis Polygoni Multiflori, 0～4 part of Fructus Lycii, 0～5 part of Radix Astragali, 0～4 part of Radix Codonopsis, 1～5 part of Carapax Trionycis or Carapax et Plastrum Testudinis, 2～4 parts
Radix Salviae Miltiorrhizae, 0～4 part of Rhizoma Chuanxiong, 0～5 part of Semen Persicae or Flos Carthami, 0～5 part of Rhizoma Curcumae, 0～5 part of Radix Curcumae, 1～5 part of Eupolyphaga Seu Steleophaga, 0～5 part of water
Trematodiasis or Tabanus, 0～5 part of Radix Rehmanniae Preparata, 0～5 part of Radix Angelicae Sinensis, 1～5 part of Radix Polygoni Multiflori or Fructus Mori, 1～5 portion of Semen Cassiae, 0～5 portion of Herba Celosiae argenteae
Son, 1～5 part of Concha Haliotidis or Flos Chrysanthemi, 0～5 part of Hippocampus, 1～5 part of Herba Cistanches, 0～5 part of Semen Juglandis or Semen Cuscutae etc. are raw material system
The capsule become, has the auxiliary therapeutic actions such as calcium-tonifying bone-strengthening, health invigorating, balanced nutrients, anti-ageing Fructus Alpiniae Oxyphyllae, toxin expelling and skin care.
Modern study also indicates that under physiological conditions, and women is after 35 years old, under follicle and oocyte quality there will be drastically
Fall, causes reduce fertility.But along with the development of society, living environment and the change of rhythm of life, this rule also occurs
Change.According to clinical observation, the original aging course of women is advanced by about 5 years, within 30 years old, has seen tired out, and face loses light
, even there is pigmentation in pool, and the hormonal readiness of ovary declines accordingly, about 40 years old existing infrequent menstruation or more climacteric disease
Shape.Ovarian hypofunction is in addition to causing occurring infrequent menstruation, amenorrhea in advance, also with infertile and miscarry relevant.And women now
In addition to hard work pressure to be faced, due to the postponement of universal childbearing age, more to face the immense pressure of fertility difficulty.As
What solves this is done sth. in advance aging phenomenon, improves the quality of living and fertility, is the difficult point of current reproductive medicine research.Clinically
The Therapeutic Method of doctor trained in Western medicine many employings complementing estrogen, but prolonged application has again carcinogenic misgivings.For infertile patient Shang Kecai
By the method for Assisted Reproductive Technology ART such as test-tube baby (IVF-ET), but after Ovarian hyperstimulation, the ovum quality obtained is poor, obtain ovum rate and
Transplantation embryo number is decreased obviously, have 9%～26% the startup cycle can because of fail without sufficient amount of follicular development obtain
Transplantable embryo even cancels the cycle, becomes the one of the main reasons that the methods such as test-tube baby are failed.
In order to improve the growth promoter of follicle, improve ovulation rate and the pregnancy rate of patient, carried out much exploring, and shape
All multirows are become and effective treatment technology scheme.As: Chinese invention patent ZL201110226280.4 disclose a kind of for
The Chinese medicine composition of insufficiency of kidney-YANG phlegm retention polycystic ovarian syndrome, it is with the Herba Epimedii of weight portion 12-21 and weight portion 9-24
Bulbus Fritillariae Uninbracteatae is monarch drug, and weight portion is that the Fructus Psoraleae of 12-21, weight portion are the Cornu Cervi tablet of 6-15 and the Hippocampus that weight portion is 0.3-15 is
Ministerial drug, weight portion is that the Carapax et Plastrum Testudinis of 9-21, weight portion are the Spina Gleditsiae of 9-21 and the Rhizoma Acori Graminei that weight portion is 9-21 is that adjuvant drug prepares.
Said composition reduces androgen and the Androgen Receptor Level of PCOS patient, improves sex hormone binding globulin level, reduces trip
From testosterone levels, improve internal estrogen level further, improve the growth promoter of follicle, improve ovulation rate and the gestation of patient
Rate.
For another example: Chinese invention patent ZL201110270264.5 discloses a kind of for deficiency of the kidney yin intermingled phlegm and blood stasis type many capsules ovum
The Chinese medicine composition of nest syndrome, its with the Rhizoma Anemarrhenae of weight portion 9-21, weight portion 9-24 Bulbus Fritillariae Uninbracteatae as monarch drug, weight portion is 9-21
Carapax et Plastrum Testudinis, weight portion be the Radix Polygoni Multiflori Preparata of 12-24, weight portion be the Radix Angelicae Sinensis of 9-21, weight portion be the Radix Ophiopogonis of 9-24 be ministerial drug, weight
Part it is adjuvant drug for the Hippocampus of 0.3-15, and Spina Gleditsiae and Rhizoma Acori Graminei.Said composition can reduce androgen and the hero of PCOS patient
Hormone receptor level, improves sex hormone binding protein level, reduces free testosterone level, improves internal estrogen water further
Flat, improve the growth promoter of follicle, improve ovulation rate and the pregnancy rate of patient.
Additionally, in terms of improving female dimacteric syndrome, such as: Chinese invention patent application 200510031012.1 disclosure
The Chinese medicine composition of a kind for the treatment of women's fatigue in climacteric period, using Chinese crude drug Carapax et Plastrum Testudinis and Herba Epimedii is principal agent, is equipped with other
Chinese medicine Hippocampus, Fructus Lycii, the Radix Polygoni Multiflori and Semen Ziziphi Spinosae, by taking the method for " being decocted first " and " under Hou " to make by medical material quality difference.Should
Chinese medicine composition has kidney-tonifying health-care, and the function that punching is appointed is adjusted in skin care, occurs after treating menopausal women or artificial menopause
Vexed xerostomia, warm sweating, fatiguability and emotion and the climacteric syndrome such as automatic control cannot have good result.
And for example: Chinese invention patent ZL200510079323 discloses a kind of Chinese medicine composition treating climacteric syndrome
Thing, using Chinese medicine Carapax et Plastrum Testudinis and Herba Epimedii is principal agent, is equipped with Anemarrhena asphodeloides Bge, Fructus Lycii, Hippocampus, Radix Polygoni Multiflori, Rhizoma Polygonati, Radix Scutellariae, Rhizoma Coptidis, stone
Cream, Radix Et Rhizoma Rhei, Semen Ziziphi Spinosae and Semen Persicae, the capsule of the climacteric syndrome occurred after making treatment menopausal women or artificial menopause
Agent, powder or tabletted agent medicine.By there is vexed xerostomia, warming sweating, emotion fluctuating to 547 examples in this pharmaceutical composition
Cannot automatic control, forgetful, dizzy, insomnia, melancholy or halitosis, the female patient of climacteric syndrome of toothache constipation symptom try out,
Result display determined curative effect, persistently, without any untoward reaction, safely and effectively.
But these achievements in research stay in climacteric women more concern, and not for all ages and classes women
The physiological and pathological feature of (such as: " woman 30 ", " woman 40 " and " woman 50 " etc.), all can blanket ovarian function regulation side
Case, thus improve the aspects such as the menstruation of women, General Symptoms and energy and have improvement result.
Summary of the invention
It is an object of the present invention to provide a kind of compositions for regulating ovarian function, it is adaptable to ovarian function
It is adjusted, thus improves the ovarian function of patient, improve the quality of living.
A kind of composite preparation for regulating ovarian function of offer is provided, is simultaneously suitable for
Adjust " 30 ", " 40 " and " 50 " these three different age group women, improve the ovarian function of patient, thus improve their menstruation
The aspects such as situation, General Symptoms and energy, improve fertility and quality of life.
The traditional Chinese medical science is thought, " kidney governing reproduction ", and the regulation with female reproduction physiological function has substantial connection.Lead on kidney in brain (" kidney
The raw marrow of main bone " " the brain being the reservoir of the marrow "), lower Lian Chongren, uterus (" kidney is appointed originally for punching " " the collaterals of the uterus connecting with the kidney "), thus constitute
The axis of brain-kidney-punching times-uterus such a regulation female reproduction physiological function, it regulates punching by " menses " and appoints born of the same parents
The function in palace, this is from macroscopically having forgiven modern medicine hypothalamic-pituitary-ovarian axis by various hormones, cytokine
Understanding Deng regulation female reproductive function.For many years in clinic and the laboratory observation that kidney-nourishing tcm drug is treated ovarian hypofunction
It has been found that in premature ovarian failure patient's therapy of combining Chinese and Western medicine, can when gonadotropin releasing hormone (FSH) is not reduced to normal
Become pregnant to obtain normal pregnancy.The kidney tonifying Chinese medicine that relieves inflammation or internal heat can make on the Estrogen Receptor of women and the old rats entered into the climacteric period
Rising, make the FSH increased and lutropin (LH) level decline, immunologic function improves, and the climacteric women having in treatment obtains
Normal pregnancy.This type of clinical picture shows that kidney-nourishing tcm drug can improve estrogen receptor amount and the function of internal aging, has regulation god
Through the effect of endocrine metabolism immunological network, from improving systemic organs, such as: organs such as brain, the heart, spleen, ovary and skins
Function.On the basis of above clinical practice with animal experiment study, from the viewpoint of " vital experiences ", for difference
The physiological and pathological feature of age women, with the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, sums up " woman 30 ", " woman 40 ", and " woman 50 " are suitable for
Conditioning prescription, to adjust the life network function of these three different age group women.
" patient " alleged by the present invention refers to suffer from the people of disease, wild animal and domestic animal (Livestock).Wild animal is
Without the animal of domestication under naturalness.Domestic animal is to provide for the animal of food source and artificial breeding, such as: monkey, ape,
Canis familiaris L., Mus, hamster, pig, rabbit, milch cow, Babalus bubalis L., bull, sheep and goat etc.." experimenter " the prioritizing selection suckling giving diagnosis is moved
Thing, especially people.
Carapax et Plastrum Testudinis, salty sweet is slightly cold into Liver and kidney heart channel, and for the product that flesh and blood is in love, nourishing YIN for benefiting the kidney, with it as monarch drug in the present invention.
Hippocampus, Gan Wen returns Liver and kidney warp, is also the in love product of flesh and blood, the kidney warming qi-restoratives, matches monoyin and monoyang with Carapax et Plastrum Testudinis, asks in sun
The moon, plays the merit of liver and kidney tonifying, altogether with it as ministerial drug in the present invention.
Bulbus Lilii, sweet trembles with fear into cardiopulmonary warp, has the merit of yin nourishing clearing away heart-fire for tranquillization, can asthenic fire clearly, treat restlessness of asrhenia type and insomnia, in the present invention
With it as ministerial drug.
A kind of compositions for regulating ovarian function that the present invention provides, with Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be as minister
Medicine, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21.
Theory of Chinese medical science is thought, the hepatic and renal YIN deficiency, easily causes hyperactivity of the ministerial fire, and fire disturbance heart-fire, causes heart kidney not the most clinically mutually
The clinical symptoms handed over, such as: insomnia and agitation etc..It is therefore believed that women ovarian hypofunction clinic belongs to the hepatic and renal YIN deficiency, the heart more
The disease that kidney is not handed over.Clinical treatment is with enriching yin and nourishing kidney, and double clearing away heart-fire is main.In conjunction with the feature in female patient all ages and classes stage,
According to the weight of the state of an illness, ovarian hypofunction is divided into deficiency of kidney-QI, deficiency of the kidney yin interior-heat, and the hepatic and renal YIN deficiency, disarmony between the heart and kidney etc. three
The individual stage.Clinic can selected application according to the weight of the age of patient or the state of an illness to above-mentioned three kinds of medicines.Additionally, go back root
Physiological characteristics according to different age group, in addition it is also necessary to combining the actual state of an illness increases one or more medicines.
Fructus Lycii, sweet puts down into Liver and kidney spleen lung meridian, has tonifying kidney and nourishing liver, and improving eyesight is calmed the nerves, and can solve face poison, and easy color, the merit such as bleach
Effect.
Herba Epimedii, sweet micro-pungent temperature enters Liver and kidney warp, has effect of Kidney-invigorating and tendon-reinforcing, can control the cloudy absolutely loss of fecundity of woman, and the middle age is forgetful
Deng disease.
The Radix Polygoni Multiflori, bitter sweet tepor enters Liver and kidney warp, has kidney tonifying tonifying liver, can please face by hair color.
The Rhizoma Anemarrhenae, bitter cold enters lung, harmonization of the stomach kidney channel, has nourishing kidney-yin clearind deficient heat, effect that relieving restlessness is allayed excitement.
Rhizoma Polygonati, sweet puts down into lung, spleen stomach function regulating warp, has spleen reinforcing lung moistening and the effect of skin care of promoting the production of body fluid.
Cortex Moutan, works hard and is slightly cold into the heart, liver, kidney and pericardium channel, have and blood removing heat from blood, controls the blood fire second of the three ten-day periods of the hot season, effect of heat clearing away and restlessness relieving.
Gypsum Fibrosum, though entering lung stomach tri-jiao channel pungent sweet Great Cold, a small amount of and yin-nourishing drug shares thanks to fire of can harnessing the river and contains.
Semen Ziziphi Spinosae, sweet acidity is put down into liver heart channel, nourishing the liver mind tranquilizing and the heart calming.
Semen Persicae, hardship is sweet puts down into cardiopulmonary warp, and intestine moistening of invigorating blood circulation is the driest at blood system.
For being main person with syndrome of deficiency of kidney-QI, it also it is the women situation more typically of " 30 " age bracket.The present invention above-mentioned by
It is additionally added Fructus Lycii, Herba Epimedii fleece-flower root in the basic side of Carapax et Plastrum Testudinis, Hippocampus and Bulbus Lilii composition.Full side invigorating kidney qi, it is adaptable to women
Kidney qi just declines, and ovarian function declines, and sees the diseases such as facial pigmentation, deficient in energy, weak, hypomnesis.
The another kind that the present invention provides for regulating the compositions of ovarian function, with Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be
Ministerial drug, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21, is additionally added weight
The amount Fructus Lycii gram of part 3-30, the Herba Epimedii of weight portion 3-21 and the Radix Polygoni Multiflori of weight portion 3-24.
It is main person for heat syndrome in deficiency of the kidney yin, is also the women situation more typically of " 40 " age bracket.The present invention is above-mentioned
It is additionally added Fructus Lycii, Herba Epimedii, the Radix Polygoni Multiflori, the Rhizoma Anemarrhenae, Rhizoma Polygonati and Cortex Moutan in the basic side being made up of Carapax et Plastrum Testudinis, Hippocampus and Bulbus Lilii.Full side is relatively
The prescription of above-mentioned " being main person with syndrome of deficiency of kidney-QI ", Cortex Moutan and Bulbus Lilii two taste medical material use simultaneously, and in side, the strength of clearing away heart-fire is relatively strong,
Its nourishing YIN and clearing away fire strength is heavier.It is applicable to deficiency of the kidney yin, ovarian hypofunction, sees xerostomia, vexed and the hepatic and renal YIN deficiency such as warm, and
Scorching all diseases on the fire of conscience.
The another kind that the present invention provides for regulating the compositions of ovarian function, with Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be
Ministerial drug, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21, is additionally added weight
The amount Fructus Lycii of part 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, weight portion 3-
Herba Epimedii, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram and the weight portion 3-15's of 21
Cortex Moutan.
For the hepatic and renal YIN deficiency, syndrome of disharmony between heart and kidney person, it also it is the women situation more typically of " 50 " age bracket.The present invention is upper
Be additionally added in stating the basic side being made up of Carapax et Plastrum Testudinis, Hippocampus and Bulbus Lilii Fructus Lycii, Herba Epimedii, the Radix Polygoni Multiflori, the Rhizoma Anemarrhenae, Rhizoma Polygonati, Cortex Moutan, Gypsum Fibrosum,
Semen Persicae and Semen Ziziphi Spinosae.
In prescription, Gypsum Fibrosum and the Rhizoma Anemarrhenae share not specially Zhi Yangming qifen fever, to deficiency of YIN fire Sheng person, help the merit of Rhizoma Anemarrhenae heat clearing away
Effect.The addition of Semen Ziziphi Spinosae has the moon of principal drug assistance nourishing the liver and kidney, and has the merit of nourishing YIN for suppressing the hyperactive YANG arresting sweating.Semen Persicae, in this prescription, has
Priming is had to enter the merit of blood.The heart is monarch fire, Liver and kidney be mutually fire, monarch fire recklessly act, fire also can move therewith mutually, be more easy to consumption impairing the liver kidney it
The moon, aggravates disease, and therefore adds Cortex Moutan and the medicine of Bulbus Lilii clearing away heart-fire, can stop this vicious cycle, increases clinical efficacy.
Full side, on the basis of the moon of nourishing the liver and kidney, strengthens the strength of clearing away heart-fire for tranquillization, and with nourishing kidney easing the affected liver, clearing away heart-fire for tranquillization is main.It is suitable for
Ovarian hypofunction patient scorching in the hepatic and renal YIN deficiency, the fire of conscience, see vexed xerostomia, warm sweating, emotion rise and fall cannot from
The inclined severe one of abnormal emotion-thought such as control, forgetful, dizzy, insomnia and melancholy.
The another kind that the present invention provides for regulating the compositions of ovarian function, with Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be
Ministerial drug, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21, is additionally added weight
The amount Fructus Lycii of part 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, weight portion 3-
The Herba Epimedii of 21, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, weight portion 3-15
Cortex Moutan, the Gypsum Fibrosum of weight portion 3-30, the Semen Persicae of weight portion 3-15 and the Semen Ziziphi Spinosae of weight portion 3-20.
The various compositionss for regulating ovarian function that the present invention provides, make decoction by decocting method, or by the traditional Chinese medical science
Traditional method makes unguentum, pill, powder and patch.
The beneficial effect that technical solution of the present invention realizes:
The present invention provide for regulating the compositions of ovarian function, with Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii as ministerial drug, be
From the viewpoint of " vital experiences ", for the physiological and pathological feature of all ages and classes women, with the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, always
Bearing " woman 30 ", " woman 40 ", the conditioning prescription that " woman 50 " are suitable for, to adjust the ovary of these three different age group women
Function, thus improve the ovarian function of patient, improve the quality of living.
Carry out being grouped and distinguishing by patient according to different Western medicine diagnose standards and Standards of Chinese Medical Syndrome Differentiation by these compositionss
Imposing the preparation that the present composition is made, after treatment in 3-6 month, patient's menstruation is obviously improved, General Symptoms (such as:
Xerostomia, vexed, leucorrhea minimizing and the soreness of waist etc.) the best.After treatment, patient's blood FSH, FSH/LH substantially reduce, and blood estradiol
(E2) and LH etc. without significant change (not statistically significant), ovarian functional status is improved, and estrogen usefulness increases.
Detailed description of the invention
Technical scheme described in detail below.The embodiment of the present invention only in order to technical scheme to be described and
Unrestricted, although the present invention being described in detail with reference to preferred embodiment, it will be understood by those within the art that,
The technical scheme of invention can be modified or equivalent, without deviating from the spirit and scope of technical solution of the present invention,
It all should be contained in scope of the presently claimed invention.
Medical material used by the embodiment of the present invention, except as otherwise indicating, all can obtain from Chinese crude drug sales company.The medicine obtained
Material, except as otherwise indicating, is tcm and herbal slice.Decoction pieces both can obtain from sales company, it is also possible to be obtain after through processing
Become.
The preparation of embodiment 1 decoction
According to patient condition, on-demand take the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, the hundred of weight portion 3-21
Conjunction, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, weight
Part Herba Epimedii of 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, weight portion 3-
The Semen Ziziphi Spinosae etc. of Cortex Moutan, the Gypsum Fibrosum of weight portion 3-30, the Semen Persicae of weight portion 3-15 and the weight portion 3-20 of 15 is suited the remedy to the case, and uses water
Soaking in container after flushing more than 2 hours, then use the fried technique of tradition under being decocted first and being rear, normal pressure decocts filter in 20 minutes
Go out medicinal liquid.
The preparation of embodiment 2 unguentum
According to patient condition, on-demand take the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, the hundred of weight portion 3-21
Conjunction, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, weight
Part Herba Epimedii of 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, weight portion 3-
The Semen Ziziphi Spinosae etc. of Cortex Moutan, the Gypsum Fibrosum of weight portion 3-30, the Semen Persicae of weight portion 3-15 and the weight portion 3-20 of 15 is suited the remedy to the case, and uses water
Soaking in container after flushing more than 2 hours, then use the fried technique of tradition under being decocted first and being rear, normal pressure leaches medicine after decocting
Liquid concentrating under reduced pressure medicinal liquid, during concentration of liquid medicine, add the required saccharide such as crystal sugar, maltose and yellow wine and the adjuvant of necessity,
Cream is received in stirring.
Follicular development is improved the observation of situation by embodiment 3
Take the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9 and the Bulbus Lilii of weight portion 3-21, make decoction, day two
Secondary oral, not drug withdrawal in menstrual period.
Monitor Follicles is carried out, method: within the 9th day, proceed by monitoring in menstrual cycle, every other day the inspection of row both transvaginal ultrasonography before and after treatment
Look into, when follicular diameter is more than 15mm, monitor once every day, when follicular diameter is more than 18mm, instructs patient, and it is straight to continue monitoring
Discharge to follicle.
Treating 106 example patients altogether, before treatment, B ultrasonic monitoring is without follicular development person 34 example, and follicular development is abnormal (includes that follicle withers
Contracting, follicle are not discharged) person 55 example, there is ovulation (including that little follicle is ovulated) person 17 example；After treatment, B ultrasonic monitoring is without follicular development (bag
Include follicle atrophy, follicle is not discharged) person 8 example, follicular development exception person 6 example, there is ovulation (including that little follicle is ovulated) person 92 example (ginseng
It is shown in Table 1).
Before and after table 1 treatment two groups of patient's situations of ovulating compare ()
Note: compare before and after treatment, " * " represents P≤0.01.
From table 1, after treatment, patient's follicle maximum gauge significantly increases, and maximum gauge is obvious with minimum diameter difference
Reduce (P≤0.05), illustrate that follicular development quality is improved.
Every hormonal readiness is improved the observation of situation by embodiment 4
Enter to organize patient by following Western medicine diagnose standard:
1) amenorrhea or delayed menstrual cycle amount are few；
2) anovular menstruation, luteal phase defect or relevant infertile, Early recurrent spontaneous abortion history；
3) endocrine detection (the 3rd day cycle) blood FSH >=8IU/L or FSH/LH >=2, E2Level is low.Age was at 40 years old
Below such as FSH ＞ 40IU/L (repeatedly checking more than 3 times), both transvaginal ultrasonography shows ovarian diameter ＜ 2cm, has no the follicle person of existence, diagnosis
For premature ovarian failure.
Take the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9 and the Bulbus Lilii of weight portion 3-21, make decoction, day two
Secondary oral, not drug withdrawal in menstrual period.After lab testing finds treatment, patient blood FSH, FSH/LH substantially reduce (P ＜ 0.01), and blood
Estradiol (E2) without significant change (being shown in Table 2).
Table 2
In table 2, " * * " represent with treatment before compare P ＜ 0.01..
After treatment, patient's blood FSH and FSH/LH is decreased obviously (P ＜ 0.01), and blood estradiol has risen, but without statistics
Meaning (P ＞ 0.05).Illustrating in the case of estrogen level is without significant change in the patient, her ovaries's functional status obtains
Improving, estrogen usefulness increases.
Embodiment 5 clinical observation
Ovarian hypofunction case load 40 example, enters to organize patient as follows by Western medicine diagnose standard:
1) amenorrhea or delayed menstrual cycle amount are few；
2) anovular menstruation, luteal phase defect or relevant infertile, Early recurrent spontaneous abortion history；
3) endocrine detection (the 3rd day cycle) blood FSH >=10IU/L, E2Level is low.Age below 40 years old such as FSH
＞ 40IU/L (checks more than 3 times) repeatedly, and both transvaginal ultrasonography shows ovarian diameter ＜ 2cm, has no the follicle person of existence, is diagnosed as ovary early
Decline.
Enter to organize patient by the Standards of Chinese Medical Syndrome Differentiation hepatic and renal YIN deficiency, syndrome of disharmony between heart and kidney:
Delayed menstrual cycle amount is few or amenorrhea, hectic fever sweating, susceptible to lose temper due to restlessness, feverish sensation in the palms and soles, insomnia and dreamful sleep, xerostomia, the soreness of waist, just
Secret, leucorrhea reduces, or mesh is done, and dry and astringent in the moon, infertile, hypomnesis, the dark red tongue of tongue is few, thready and rapid pulse.
Prescription: the Carapax et Plastrum Testudinis of weight portion 13-45, the Hippocampus of weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, weight portion 3-30
Fructus Lycii, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, the celestial spirit of weight portion 3-21
Spleen, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, the Cortex Moutan of weight portion 3-15, weight
Part Gypsum Fibrosum of 3-30, the Semen Persicae of weight portion 3-15 and the Semen Ziziphi Spinosae of weight portion 3-20.
Above-mentioned prescription is made decoction, and twice-daily is administered orally, not drug withdrawal in menstrual period.After treatment in 3-6 month, patient's menstruation
It is obviously improved, General Symptoms (such as: xerostomia, vexed, leucorrhea minimizing and the soreness of waist etc.) the best (being shown in Table 4).Arranged by controlling patient
9 examples before ovum rate has treatment increase to 36 examples (being shown in Table 3).
Table 3
In table 3, " recovery from illness " refers to that menstruation is monthly risen, occur continuously in half a year 3 ovulations or blood FSH return to 8IU/L with
Under；The General Symptoms such as xerostomia, vexed, leucorrhea minimizing is obviously improved simultaneously；" effective " refers to menstruation 30～rises once in 45 days, half a year
Inside having 2 ovulations, General Symptoms is obviously improved；" effectively " refers to that menstruation 1～February rise once, has 1 ovulation, whole body in half a year
Symptom is improved；Engineering noise refers to that menstruation can be risen, anovulation phenomenon, and General Symptoms improves.
Table 4
Table 5
In table 5, " * " represent with treatment before compare P ＜ 0.05；" * * " represent with treatment before compare P ＜ 0.01.
After treatment, patient's blood FSH and FSH/LH is decreased obviously (P ＜ 0.01 or P ＜ 0.05), and blood estradiol has risen, but
Not statistically significant (P ＞ 0.05).Illustrate in the case of estrogen level is without significant change in the patient, her ovaries's function
State is improved, and estrogen usefulness increases.
Embodiment 6 clinical observation
Ovarian hypofunction case load 36 example, enters to organize patient as follows by Western medicine diagnose standard:
1) amenorrhea or delayed menstrual cycle amount are few；
2) anovular menstruation, luteal phase defect or relevant infertile, Early recurrent spontaneous abortion history；
3) endocrine detection (the 3rd day cycle) blood FSH >=8IU/L, E2 level is low.
Enter to organize patient by heat syndrome in Standards of Chinese Medical Syndrome Differentiation deficiency of the kidney yin:
Delayed menstrual cycle amount is few or amenorrhea, feverish sensation in the palms and soles, flushing in zygomatic region red lip, and xerostomia is vexed, soreness of waist tinnitus, and leucorrhea reduces, or mesh
Dry, the few tongue thready and rapid pulse of red tongue.
Prescription: the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, weight portion 3-30
Fructus Lycii, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21,
The Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram and the Cortex Moutan of weight portion 3-15.
Above-mentioned prescription is made decoction, and twice-daily is administered orally, not drug withdrawal in menstrual period.After treatment in 3-6 month, patient's menstruation
It is obviously improved, General Symptoms (such as: xerostomia, vexed, leucorrhea minimizing and the soreness of waist etc.) the best (being shown in Table 7).Arranged by controlling patient
8 examples before ovum rate has treatment increase to 31 examples (being shown in Table 6).
Table 6
In table 7, " recovery from illness " refers to that menstruation is monthly risen, occur continuously in half a year 3 ovulations or blood FSH return to 8IU/L with
Under, meanwhile, the General Symptoms such as xerostomia, vexed, leucorrhea minimizing is obviously improved；" effective " refers to menstruation 30～rises once in 45 days, half
Having 2 ovulations in Nian, General Symptoms is obviously improved；" effectively " refers to that menstruation 1～February rise once, has 1 ovulation, entirely in half a year
Body symptom is improved；Engineering noise refers to that menstruation can be risen, anovulation phenomenon, and General Symptoms improves.
Table 7
Table 8
In table 8, " * " represent with treatment before compare P ＜ 0.05；" * * " represent with treatment before compare P ＜ 0.01.
After treatment, patient's blood FSH and FSH/LH is decreased obviously (P ＜ 0.01 or P ＜ 0.05), and blood estradiol is without significant change
(P ＞ 0.05).Illustrating in the case of estrogen level is without significant change in the patient, her ovaries's functional status is changed
Kind, estrogen usefulness increases.
Embodiment 7 clinical observation
Ovarian hypofunction case load 30 example, enters group person by Standards of Chinese Medical Syndrome Differentiation syndrome of deficiency of kidney-QI:
Delayed menstrual cycle amount is few or amenorrhea, weak, the soreness of waist, tinnitus, and leukorrhagia reduces, or has infertile, pale tongue with white fur deep-thready pulse.
Prescription: the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, weight portion 3-30
Fructus Lycii gram, the Herba Epimedii of weight portion 3-21 and the Radix Polygoni Multiflori of weight portion 3-24.
Above-mentioned prescription is made decoction, and twice-daily is administered orally, not drug withdrawal in menstrual period.After treatment in 3-6 month, patient's menstruation
It is obviously improved, General Symptoms (such as: weak, leucorrhea minimizing and the soreness of waist etc.) the best (being shown in Table 10).By the ovulation rate controlling patient
10 examples before treatment are had to increase to 25 examples (being shown in Table 9).
Table 9
In table 9, " recovery from illness " refers to that menstruation is monthly risen, occur continuously in half a year 3 ovulations or blood FSH/LH return to 2 with
Under, meanwhile, the General Symptoms such as xerostomia, vexed, leucorrhea minimizing is obviously improved；" effective " refers to menstruation 30～rises once in 45 days, half
Having 2 ovulations in Nian, General Symptoms is obviously improved；" effectively " refers to that menstruation 1～February rise once, has 1 ovulation, entirely in half a year
Body symptom is improved；Engineering noise refers to that menstruation can be risen, anovulation phenomenon, and General Symptoms improves.
Table 10
Table 11
In table 9, " * " represent with treatment before compare P ＜ 0.05.
After treatment, patient's blood FSH and FSH/LH is decreased obviously (P ＜ 0.05), blood estradiol (E2Though) and LH have rising, but
Not statistically significant (P ＞ 0.05).Illustrate in the case of estrogen level is without significant change in the patient, her ovaries's function
State is improved, and estrogen usefulness increases.
Claims (4)
1. the compositions being used for regulating ovarian function, it is characterised in that include
Monarch drug: the Carapax et Plastrum Testudinis of weight portion 5-21；
Ministerial drug: the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21；And
The Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21 and the Radix Polygoni Multiflori of weight portion 3-24.
Compositions for regulating ovarian function the most according to claim 1, it is characterised in that described compositions also adds
Enter the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, the Cortex Moutan of weight portion 3-15, the Gypsum Fibrosum of weight portion 3-30, weight
One or more of the Semen Ziziphi Spinosae of part 3-20 and the Semen Persicae of weight portion 3-15.
3. one kind for regulating the preparation of ovarian function, it is characterised in that include one of claim 1-2 described for regulating
The compositions of ovarian function.
Preparation for regulating ovarian function the most according to claim 3, it is characterised in that described preparation selected from decoction,
One or more of unguentum, pill, powder and patch.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354014A (en) * | 2001-11-29 | 2002-06-19 | 廖干甫 | Gongbu ointment |
| CN1843459A (en) * | 2005-04-06 | 2006-10-11 | 上海绿谷（集团）有限公司 | Chinese medicinal composition for treating climacteric syndrome and its preparation method |
| CN101856471A (en) * | 2010-06-09 | 2010-10-13 | 杨青 | Chinese medicinal composition for tonifying kidney and strengthening body |
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2014
- 2014-07-10 CN CN201410328211.8A patent/CN104042881B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354014A (en) * | 2001-11-29 | 2002-06-19 | 廖干甫 | Gongbu ointment |
| CN1843459A (en) * | 2005-04-06 | 2006-10-11 | 上海绿谷（集团）有限公司 | Chinese medicinal composition for treating climacteric syndrome and its preparation method |
| CN101856471A (en) * | 2010-06-09 | 2010-10-13 | 杨青 | Chinese medicinal composition for tonifying kidney and strengthening body |
Non-Patent Citations (2)
| Title |
|---|
| 更年期综合征的中医药治疗进展;李小花;《陕西中医学院学报》;20100930;第33卷(第5期);103-105 * |
| 龙牡龟板汤治疗更年期综合征36例;窦丽红;《河南中医学院学报》;20060731;第21卷(第125期);50-51 * |
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