CN104004583A - Natural health plant oil containing linoleic acid and linolenic acid as well as preparation method and application of plant oil - Google Patents
Natural health plant oil containing linoleic acid and linolenic acid as well as preparation method and application of plant oil Download PDFInfo
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- CN104004583A CN104004583A CN201410249601.6A CN201410249601A CN104004583A CN 104004583 A CN104004583 A CN 104004583A CN 201410249601 A CN201410249601 A CN 201410249601A CN 104004583 A CN104004583 A CN 104004583A
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- natural health
- vegetables oil
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- oil
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- 230000036541 health Effects 0.000 title claims abstract description 96
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 title claims abstract description 57
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 title claims abstract description 56
- 235000020661 alpha-linolenic acid Nutrition 0.000 title claims abstract description 44
- 229960004488 linolenic acid Drugs 0.000 title claims abstract description 44
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 235000020778 linoleic acid Nutrition 0.000 title claims abstract description 29
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000010773 plant oil Substances 0.000 title abstract 6
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- 239000010779 crude oil Substances 0.000 claims description 38
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 29
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- Cosmetics (AREA)
Abstract
The invention relates to the field of natural health plant oil and in particular relates to natural health plant oil containing linoleic acid and linolenic acid as well as a preparation method and application of the plant oil. The natural health plant oil is prepared from more than any four raw materials of prinsepia utilis royle seeds, elsholtziae, agastache rugosus, purple perilla seeds and safflower seeds, the synergistic effect of the raw materials is enhanced, the mass ratio of linoleic acid to linolenic acid is (4-5):1, and a prepared health product has excellent comprehensive health effects of avoiding atherosclerosis, reducing blood fat, developing intelligence, resisting ageing and tumor, improving immunity and the like; a prepared beauty skin care product is capable of remarkably improving luster and elasticity of the skin, moistening and tenderizing the skin, improving or removing skin wrinkles, keeping moisture, helping the skin absorb nutrients, delaying the skin ageing and disappearing skin redness and erosion of newborn infants. According to the preparation method, effective ingredients in the raw materials are completely remained, a process is simple, and the product quality is good.
Description
Technical field
The present invention relates to natural health vegetables oil field, in particular to natural health vegetables oil containing linoleic acid plus linolenic acid and its preparation method and application.
Background technology
Prinsepia utilis is a kind of evergreen shrubs of Rosaceae Prinsepia Royle, self-sow in Yunnan, the mountain region that cools of the province such as Sichuan, Guizhou.Have a long history Yunnan local is among the people, in kernel, leaf, contain and multiple the necessary constant of human body and trace element are contained to higher crude fat, there is clearing heat and detoxicating, anti-inflammatory, invigorate blood circulation, pain relieving, help digestion, the effect such as stomach invigorating.Prinsepia utilis royle oil has been used for many years among the people as a kind of special edible oil, and this oil is a kind of good green food, often eats and can reduce blood fat, regulates blood pressure, promotes microcirculation, the resistibility of enhancing body.Because this oil is rich in unsaturated fatty acids, form with human body sebum class and approach, so also there is the effect that makes skin regeneration reparation and moisturizing simultaneously.
The red Soviet Union of purple perilla fork name, fragrant Soviet Union etc. are a kind of traditional medicine food dual purpose plants.In China, having long plantation historical, is that first batch of what promulgate is one of 60 kinds of article of food and medicine to health ministry.Perilla oil is the fatty oil that squeezes in purple perilla dry mature fruit or extract and obtain, and in oil, main component is alpha-linolenic acid, linolic acid, oleic acid, palmitinic acid, stearic acid, eicosanoic acid, arachidonic acid etc., and wherein alpha-linolenic acid content is the highest, reaches 50%-70%.Perilla oil has reducing blood-fat to human body, hypotensive, hypoglycemic (shisonin A, c has the oxidasic effect of the aldose of inhibition, and aldose oxidase inhibitor can play an important role in diabetic syndrome treatment), antianaphylaxis inflammation, anticancer, anti-mattress, improves ability of learning and memory and retinal reflex energy, fat-reducing, nourishing function and the medical efficacy of relievining asthma etc.
Elscholtiza is that Labiatae elscholtiza belongs to oilseed plant, China's elscholtiza aboundresources, and only southwest (Yunnan, Guizhou, Sichuan, Tibet) is just distributed with 30 kinds.Elscholtiza is that health ministry announced for 2002 is one of article list of food and medicine.Herba Moslae oil main component is alpha-linolenic acid 56.82%, linolic acid 19.79%, oleic acid, stearic acid, palmitinic acid etc.
Safflower (Yunnan black tea flower) is composite family dicotyledons, contains tryptamine derivatives anti-oxidant and elimination free radical activity, linolic acid, protein, amino acid, the compositions such as vitamins B in its seed oil.Thistle oil has extra high frost resistance, savory stable, and softening cardiovascular and cerebrovascular, reduces cholesterol, and blood pressure, prevents arteriosclerosis, promotes the growth of children's's brains, improves the effects such as intelligence.
Prinsepia utilis and elscholtiza are wild plant in Yunnan Province, aboundresources, and nutritive ingredient and effective active component content are higher than the torrid zone or low altitude area; Purple perilla Flos Carthami plant is planted commerial growing in Yunnan Province, shows very strong adaptability, and nutrient composition content is also very high.
According to statistics, currently contain linolenic acid, linoleic vegetables oil is a lot, but linolenic acid and linoleic ratio is wherein unreasonable, can cause the unbalance of Nutrition and Metabolism, affects HUMAN HEALTH; Prinsepia utilis, elscholtiza, wrinkled giant hyssop, purple perilla Flos Carthami are China's traditional plant, among the people with a long history with clinical application, but majority is independent use, and minority is certain several formula use that is combined into wherein, and its effect neither be very desirable.
Summary of the invention
The object of the present invention is to provide natural health vegetables oil relating to containing linoleic acid plus linolenic acid and its preparation method and application, to solve the above problems.
Natural health vegetables oil containing linoleic acid plus linolenic acid is provided in an embodiment of the present invention, comprise any four kinds of above natural health vegetables oil of making as raw material of usining in Prinsepia utilis seed, perilla seed, elscholtiza, wrinkled giant hyssop Flos Carthami seed, wherein, in described natural health vegetables oil, linolic acid and linolenic mass ratio are 4-5:1.
Preferably, to account for the weight percent of described natural health content of vegetable oil be 40-50% to described linolic acid.
Preparation method containing the natural health vegetables oil of linoleic acid plus linolenic acid is provided in embodiments of the invention, has comprised the following steps:
A, under hydraulic pressure normal temperature, described raw material be take to pressure and under 20-60MPa, squeezes after certain hour, pressure release to pressure makes zero, and obtains squeezing crude oil;
B, the raw material squeezing is carried out to supercritical CO
2extraction is extracted crude oil;
C, described squeezing crude oil and described extraction crude oil are mixed, first through thin film distillation dehydration, degassed and deodorization, activated decoloration then, last freezing dewaxing, obtains described natural health vegetables oil.
Preferably, in described step C, described squeezing crude oil and described extraction crude oil are standing more than 30 minutes at 10 ℃-50 ℃ after mixing.
The application in preparing healthcare products of natural health vegetables oil containing linoleic acid plus linolenic acid is provided in embodiments of the invention.
Preferably, by weight percentage, the addition of described natural health vegetables oil in healthcare products is 1-100%.
Preferably, described healthcare products are pure described natural health vegetables oil;
Or
Consisting of of described healthcare products:
Described natural health vegetables oil 2-95%
Vitamin-E 1-5%
Vitamin A 2-5%
Vitamins B 2-4%
Surplus is healthcare products edible adjuvant;
Preferably, described healthcare products edible adjuvant comprises one or more in commercially available edible flour or starch, Pollen Pini, pectin, lamb's-quarters flour and honey.
The application in preparing cosmetics and skincare product of natural health vegetables oil containing linoleic acid plus linolenic acid is provided in embodiments of the invention.
Preferably, by weight percentage, the addition of described natural health vegetables oil in cosmetics and skincare product is 10-90%.
Preferably, described cosmetics and skincare product comprises following composition: by weight percentage,
Described natural health vegetables oil 10-90%
Asian puccoon 1-10%
Vitamin-E 1-5%
Surplus is cosmetics and skincare product auxiliary material;
Preferably, preferably, described cosmetics and skincare product auxiliary material comprises any one or more in aloe water extract, aloe alcohol extract, aqueous extract from Eucommia ulmoides, ulmoprenol extract, only nail aqueous extract, only nail alcohol extract, Paris polyphylla aqueous extract, rhizoma paridis, Moisture factor and the whitening factor.
The natural health vegetables oil containing linoleic acid plus linolenic acid that the embodiment of the present invention provides, with any four kinds of above raw materials in Prinsepia utilis seed, elscholtiza, wrinkled giant hyssop, perilla seed Flos Carthami seed, make natural health vegetables oil, composition between its each raw material has mutual cooperation enforcement effect, and linolic acid and linolenic mass ratio are 4-5:1, linolic acid and alpha-linolenic acid are competed the same enzyme in metabolism, being competition inhibition relation, keeping balanced proportions between the two, is to maintain healthy basis.Preparation method's efficiency of natural health vegetables oil provided by the invention is good, the effective constituent in complete reservation Prinsepia utilis seed, elscholtiza, perilla seed Flos Carthami seed, and technique is simple, good product quality.The application of natural health vegetables oil in preparing healthcare products and cosmetics and skincare product, the healthcare products that obtain contain linolic acid and alpha-linolenic acid, by being combined with cholesterol in human body, carry out metabolism, thereby eliminate the artery deposition that cholesterol forms in human body, avoid atherosclerosis; Linolic acid and alpha-linolenic acid, as prostaglandin(PG) synthetic raw material in vivo, can suppress the hydrolysis of triglyceride level, reduce blood fat; Alpha-linolenic acid also has brain tonic, and intelligence development is anti-ageing, antitumor, strengthening immunity, and the natural health vegetables oil containing linoleic acid plus linolenic acid obtaining has excellent comprehensive health-care performance; The cosmetics and skincare product making, can obviously increase gloss and the elasticity of skin, moistens, delicate skin, improves or eliminates wrinkle of skin, and moisturizing, helps skin to absorb nutritive ingredient, and delaying skin aging makes newborn baby's skin and red swelling of the skin, rotten to the corn disappearance.The healthcare products that the applicant is contained natural health vegetables oil provided by the invention through several years practical application proof are safe and effective.
Embodiment
Below by specific embodiment, the present invention is described in further detail.
Natural health vegetables oil containing linoleic acid plus linolenic acid provided by the invention, comprise any four kinds of above natural health vegetables oil of making as raw material of usining in Prinsepia utilis seed, perilla seed, elscholtiza, wrinkled giant hyssop Flos Carthami seed, wherein, in described natural health vegetables oil, linolic acid and linolenic mass ratio are 4-5:1.
Linolic acid is ω-6PUFA (polyunsaturated fatty acid, abbreviation PUFA) parent, it in vivo metabolism become gamma-linolenic acid, arachidonic acid (AA), AA generates the biologically active substances such as thromboxane A2 (TXA2), prostacyclin (PGI2), leukotriene B4 (LTB4), prostaglandin E2 (PGE2) under the effect of cyclooxygenase and lipoxidase; Alpha-linolenic acid is the parent of ω-3PUFA, can generate in vivo the materials such as timnodonic acid (EPA) and docosahexenoic acid (DHA).EPA generates the biologically active substances such as LTB5, TXA3, PGI3 under the effect of cyclooxygenase and lipoxidase.Linolic acid and alpha-linolenic acid are competed the same enzyme in metabolism, are competition inhibition relations, keep balanced proportions between the two, are to maintain healthy basis.
Linolic acid and alpha-linolenic acid possess certain proportion in content of vegetable oil, the function of competence exertion excellence.Preferably, to account for the weight percent of described natural health content of vegetable oil be 40-50% to described linolic acid.Linolic acid and alpha-linolenic acid are unsaturated fatty acids, be needed by human and can not lean on the synthetic lipid acid of human body self, its in human body with the solid liquor-saturated combination of courage after, just can carry out normal metabolism, thereby eliminate the artery deposition that cholesterol forms in human body, avoid atherosclerosis; Another important physiological function of linolic acid and alpha-linolenic acid is as prostaglandin(PG) synthetic raw material in vivo, so that suppress the hydrolysis that glycerine three is made, reduces blood fat; Alpha-linolenic acid has brain tonic, and intelligence development is anti-ageing, antitumor, strengthening immunity.
The present invention also provides the preparation method containing the natural health vegetables oil of linoleic acid plus linolenic acid, comprises the following steps:
A, under hydraulic pressure normal temperature, described raw material be take to pressure and under 20-60MPa, squeezes after certain hour, pressure release to pressure makes zero, and obtains squeezing crude oil;
B, the raw material squeezing is carried out to supercritical CO
2extraction is extracted crude oil;
C, described squeezing crude oil and described extraction crude oil are mixed, first through thin film distillation dehydration, degassed and deodorization, activated decoloration then, last freezing dewaxing, obtains described natural health vegetables oil.
In order to reduce impurity, preferably, before squeezing, whole raw materials are carried out to cleaning and process, Prinsepia utilis seed, perilla seed, wrinkled giant hyssop, elscholtiza (complete stool of wrinkled giant hyssop and elscholtiza or seed, leaf, stem) Flos Carthami seed raw material are cleaned up standby.
Squeezing can be squeezed together also and can be squeezed respectively, and each composition raw material squeezes respectively, or squeezing together after mixing in certain proportion; After pressure is 20-60MPa squeezing certain hour, be that the seed pressure break of each raw material is opened; Wherein, wrinkled giant hyssop and elscholtiza complete stool or leaf, stem powder carry out supercritical CO after can squeezing
2extraction; Can not squeeze, the complete stool of wrinkled giant hyssop and elscholtiza or leaf, stem are ground into 60-80 object powder, directly carry out supercritical CO yet
2extraction.If squeezing respectively, surveys the linolenic and linoleic content in each material oil after squeezing, then carry out proportioning, obtain the crude vegetal that linolic acid and linolenic mass ratio are 4-5:1; If squeeze together, before squeezing, need to calculate the usage quantity of each material, then squeezing together.
Preparation method's efficiency of the natural health vegetables oil containing linoleic acid plus linolenic acid provided by the invention is good, the effective constituent in complete reservation Prinsepia utilis seed, elscholtiza, perilla seed Flos Carthami seed, and technique is simple, good product quality.
Preferably, in described step C, described squeezing crude oil and described extraction crude oil are standing more than 30 minutes at 10 ℃-50 ℃ after mixing.
Standing more than 30 minutes at standing 10 ℃-50 ℃ after squeezing crude oil and extraction crude oil mix, be that composition profiles is homogeneous more in order better to merge between the two.More preferably, described squeezing crude oil and described extraction crude oil reach the effect of mutual fusion for standing 30-40 minute after mixing at 40 ℃-50 ℃.After standing through thin film distillation dehydration, degassed and deodorization, activated decoloration then, last freezing dewaxing, obtains natural health vegetables oil, the natural health vegetable oil purity obtaining is high, high purity, and between each composition, amalgamation is good.
The application of natural health vegetables oil containing linoleic acid plus linolenic acid provided by the invention in preparing healthcare products.Natural health vegetables oil containing linoleic acid plus linolenic acid has several functions: avoid atherosclerosis; Reduce blood fat; Brain tonic, intelligence development, anti-ageing, antitumor, strengthening immunity etc., therefore, are the desirable feedstock of healthcare products.
Preferably, by weight percentage, the addition of described natural health vegetables oil in healthcare products is 1-100%.
Healthcare products provided by the invention, by weight percentage, described healthcare products are pure described natural health vegetables oil
Or
Consisting of of described healthcare products:
Described natural health vegetables oil 2-95%
Vitamin-E 1-5%
Vitamin A 2-5%
Vitamins B 2-4%
Surplus is healthcare products edible adjuvant;
Preferably, described healthcare products edible adjuvant comprises one or more in commercially available edible flour or starch, Pollen Pini, pectin, lamb's-quarters flour and honey.
The healthcare products that adopt a certain proportion of natural health vegetables oil and vitamin A, B, E and some auxiliary materials to prepare, the mutual synergy of active substance between each composition, has better over-all properties.
The present invention also provides the application in preparing cosmetics and skincare product of natural health vegetables oil containing linoleic acid plus linolenic acid.Linoleic acid plus linolenic acid is unsaturated fatty acids, participate in vivo the synthetic of phosphatide, and exist in plastosome and cytolemma with phospholipid form, be used in all kinds of cosmetics and skincare products, can obviously increase gloss, the elasticity of skin, moist, delicate skin, improve or elimination wrinkle of skin, moisturizing, help skin to absorb nutritive ingredient, delaying skin aging, makes newborn baby's skin and red swelling of the skin, rotten to the corn disappearance, therefore, the present invention says that the natural health vegetables oil containing linoleic acid plus linolenic acid providing is the desirable feedstock of cosmetics and skincare product.
Particularly, by weight percentage, the addition of described natural health vegetables oil in cosmetics and skincare product is 10-90%.
Cosmetics and skincare product provided by the invention, comprises following composition: by weight percentage,
Described natural health vegetables oil 10-90%
Asian puccoon 1-10%
Vitamin-E 1-5%
Surplus is cosmetics and skincare product auxiliary material;
Preferably, preferably, described cosmetics and skincare product auxiliary material comprises any one or more in aloe water extract, aloe alcohol extract, aqueous extract from Eucommia ulmoides, ulmoprenol extract, only nail aqueous extract, only nail alcohol extract, Paris polyphylla aqueous extract, rhizoma paridis, Moisture factor and the whitening factor.
Asian puccoon is wherein the powder that is ground into cosmetic standard specification, then after fully mixing with other raw materials, then sterilizing bottling, obtains cosmetics and skincare product.
The cosmetics and skincare product that adopts a certain proportion of natural health vegetables oil and vitamin-E, Asian puccoon and some auxiliary materials to prepare, the mutual synergy of active substance between each composition, has better beauty and skin care performance.
Embodiment 1
In weight part, take respectively 15 parts of Prinsepia utilis seeds, 50 parts of perilla seed, 6 parts of elscholtiza seeds, 10 parts of 19 parts of Flos Carthami seeds of wrinkled giant hyssop seed, after cleaning up, dry standby;
Under hydraulic pressure normal temperature, by Prinsepia utilis seed, perilla seed, elscholtiza seed, wrinkled giant hyssop seed Flos Carthami seed, at pressure, be to squeeze after certain hour under 20MPa respectively, pressure release to pressure makes zero, and obtains squeezing crude oil;
Respectively each raw material squeezing is carried out to supercritical CO
2extraction is extracted crude oil;
The squeezing crude oil obtaining and extraction crude oil are mixed, standing more than 5 hours at 10 ℃, first through thin film distillation dehydration, degassed and deodorization, then activated decoloration, last freezing dewaxing, obtains natural health vegetables oil, and in natural health vegetables oil, linolic acid and linolenic mass ratio are 4:1, wherein, to account for the weight percent of natural health content of vegetable oil be 40% to linolic acid.
Embodiment 2
In weight part, take respectively 10 parts of Prinsepia utilis seeds, 70 parts of perilla seed, 12 parts of elscholtizas, 8 parts of Semen Flos Carthamis, dry standbyly after cleaning up, and wherein, elscholtiza is complete stool;
Under hydraulic pressure normal temperature, by Prinsepia utilis seed, perilla seed Flos Carthami seed, at pressure, be to squeeze after certain hour under 40MPa, pressure release to pressure makes zero, and obtains squeezing crude oil;
The complete stool of the elscholtiza cleaning up is ground into 60 object powder;
The powder of the raw material squeezing and elscholtiza is carried out to supercritical CO
2extraction is extracted crude oil;
The squeezing crude oil obtaining and extraction crude oil are mixed, standing more than 2 hours at 30 ℃, first through thin film distillation dehydration, degassed and deodorization, then activated decoloration, last freezing dewaxing, obtains natural health vegetables oil, and in natural health vegetables oil, linolic acid and linolenic mass ratio are 5:1, wherein, to account for the weight percent of natural health content of vegetable oil be 50% to linolic acid.
Embodiment 3
In weight part, take respectively 60 parts of perilla seed, 10 parts, elscholtiza leaf, 20 parts of 10 parts of Flos Carthami seeds of Radix agastaches, after cleaning up, dry standby;
Under hydraulic pressure normal temperature, by perilla seed Flos Carthami seed, at pressure, be to squeeze after certain hour under 60MPa, pressure release to pressure makes zero, and obtains squeezing crude oil;
The Radix agastaches cleaning up and elscholtiza leaf are ground into 50-60 object powder;
The powder of the raw material squeezing and wrinkled giant hyssop and elscholtiza is carried out to supercritical CO
2extraction is extracted crude oil;
The squeezing crude oil obtaining and extraction crude oil are mixed, standing more than 50 minutes at 40 ℃, first through thin film distillation dehydration, degassed and deodorization, then activated decoloration, last freezing dewaxing, obtains natural health vegetables oil, and in natural health vegetables oil, linolic acid and linolenic mass ratio are 4.5:1, wherein, to account for the weight percent of natural health content of vegetable oil be 45% to linolic acid.
Embodiment 4
In weight part, take respectively 20 parts of Prinsepia utilis seeds, 55 parts of perilla seed, 20 parts of 5 parts of Flos Carthami seeds of wrinkled giant hyssop stem, after cleaning up, dry standby;
Under hydraulic pressure normal temperature, by Prinsepia utilis seed, perilla seed, wrinkled giant hyssop stem Flos Carthami seed, at pressure, be to squeeze after certain hour under 40MPa, pressure release to pressure makes zero, and obtains squeezing crude oil;
The raw material squeezing is carried out to supercritical CO
2extraction is extracted crude oil;
The squeezing crude oil obtaining and extraction crude oil are mixed, standing more than 30 minutes at 50 ℃, first through thin film distillation dehydration, degassed and deodorization, then activated decoloration, last freezing dewaxing, obtains natural health vegetables oil, and in natural health vegetables oil, linolic acid and linolenic mass ratio are 4.6:1, wherein, to account for the weight percent of natural health content of vegetable oil be 42% to linolic acid.
Wherein, each raw material in embodiment 1-4 is commercially available dry products.
Test example 1
Select 200 people of age level between 40 years old to 65 years old and be divided into two groups, taking embodiment 1 for one group and produce the natural health vegetables oil obtaining, as test group; Take the fish oil that the U.S. produces for one group, as a control group.
Instructions of taking, observational technique, curative effect judgment criteria are as follows:
1, instructions of taking
Control group is taken the fish oil that the U.S. produces, and takes described in its specification sheets; Test group is taken the embodiment of the present invention 1 natural health vegetables oil is provided, a twice-daily, each 5ml; All by the identical course for the treatment of, take 90 days, and during taking, cut out other related drugs for two groups.
2, observational technique
Have a blood test respectively before and after taking pressure, blood fat, urine, stool routine examination and occult blood, liver, renal function.Within during taking 10 days, observe once, comprise symptom, sign improvement situation, untoward reaction.
3, curative effect judgment criteria
1, criterion of therapeutical effect
Criterion of therapeutical effect according to bureau of drug administration of the Ministry of Health about " guideline of clinical investigations of new drug (Chinese medicine) treatment hypertension, hyperlipidemia " regulation.
Cure: symptom completely dissolve, indices drops to normal value;
Effective: clinical cardinal symptom obviously alleviates, indices drops to and approaches normal value;
Effective: cardinal symptom alleviates, indices has fallen more than 50%;
Invalid: symptom alleviates to some extent, indices does not decline.
Its every improvement situation and the results are shown in Table 1.
Table 1 test group and control group patient body index determining result
During taking, find that test group patient has no adverse reaction, control group patient has the degree symptoms such as dry, scorching, constipation.
Test example 2
Adopt the natural health vegetables oil in embodiment 2 to make healthcare products one, by weight percentage, natural health vegetables oil accounts for 90%, and vitamin-E accounts for 4%, and vitamin A accounts for 2%, and vitamins B accounts for 2%, is processed into oral capsule, and every heavy 0.5g, takes two every day; Adopt the natural health vegetables oil in embodiment 3 to make healthcare products two, by weight percentage, natural health vegetables oil accounts for 95%, and vitamin-E accounts for 1%, and vitamin A accounts for 2%, and vitamins B accounts for 2%, is processed into oral capsule, and every heavy 0.5g, takes two every day; Using healthcare products one and healthcare products two as test group, as a control group, fish oil the results are shown in Table 1 to fish oil; Two test group respectively select 100 people to take; Methods for the treatment of, observational technique, curative effect judgment criteria are with test example 1.Obtain the results are shown in Table 2.
Each test group patient body index determining result of table 2
During edible, find that test group patient has no adverse reaction, control group patient has the degree symptoms such as dry, scorching, constipation.
Test example 3
The natural health vegetables oil that embodiment 4 is obtained is prepared into plurality kinds of health care product three, the composition containing in the healthcare products three of preparation, percentage ratio meter by weight, (1) natural health vegetables oil accounts for 46%, vitamin-E accounts for 2%, vitamin A accounts for 2%, vitamins B accounts for 2%, edible flour accounts for 48%; (2) natural health vegetables oil accounts for 2%, vitamin-E accounts for 5%, vitamin A accounts for 5%, vitamins B accounts for 4%, honey accounts for 30%, Pollen Pini accounts for 56%; (3) natural health vegetables oil accounts for 30%, lamb's-quarters flour 6%, vitamin-E account for 3%, vitamin A accounts for 3%, vitamins B accounts for 3%, starch accounts for 50%, pectin accounts for 5%, by existing working method, it is made respectively to the medicinal granules of every bag of heavy 10g.Respectively select 50 people to take the healthcare products of preparation three, take two bags every day.Methods for the treatment of, observational technique, curative effect judgment criteria are with test example 1.Fish oil is routine in contrast simultaneously, and reference examples result is as test example 1.Efficiently the results are shown in Table 3.
Each test group patient body index determining result of table 3
During edible, find that test group patient has no adverse reaction, control group patient has the degree symptoms such as dry, scorching, constipation.
From test group 1-3, can find out, healthcare products provided by the invention comprise the natural health vegetables oil containing linoleic acid plus linolenic acid, the mutual chemiluminescence of each composition of healthcare products mutually making after collocation, absorbs better, has following effect: can avoid atherosclerosis; Reduce blood fat; Brain tonic, intelligence development, anti-ageing, antitumor, strengthening immunity etc., the healthcare products of the natural health vegetables oil containing linoleic acid plus linolenic acid obtaining have excellent comprehensive health-care performance.
Test example 4
1. by weight percentage, get the natural health vegetables oil 10% making in embodiment 3; Asian puccoon 10%; Vitamin-E 3%; Aloe water extract 28%; Aqueous extract from Eucommia ulmoides 15%; Only nail alcohol extract 24%; The whitening factor 10%, mixes each composition to make cosmetics and skincare product.
2. by weight percentage, get the natural health vegetables oil 50% making in embodiment 3; Asian puccoon 1%; Vitamin-E 5%; Rhizoma paridis 10%, Moisture factor 20%, the whitening factor 14%, mixes each composition to make cosmetics and skincare product.
3. by weight percentage, get the natural health vegetables oil 90% making in embodiment 3; Asian puccoon 5%; Vitamin e1 %; Moisture factor 4%, mixes each composition to make cosmetics and skincare product.
Select 360 people, be divided at random 4 groups, 1 group is control group, and another 3 groups is test group, and test group 1-3 is corresponding 3 kinds of products above use each corresponding cosmetics and skincare product respectively; Control group is used commercially available large precious board skin care product; Each group is all used 20 days by same program, and wherein, skin elasticity increase, the increase of skin delicacy degree and moisturizing effect are by national skin care product standard detection, and effect is also undertaken by national standard; It is as shown in table 4 that its skin quality is improved situation.
Table 4 skin quality is improved situation
Respectively select the baby of 10 routine red swelling of the skin erosions to test at random, smear after the cosmetics and skincare product of 1,2,3 group, red swelling of the skin all disappeared at the 3rd day, and rotten to the corn skin disappeared at 10,7,6 days respectively; And use the baby of the SOD albumen honey of treasured greatly, the rotten to the corn symptom of red swelling of the skin is all invalid.
From test example 4, can find out, the cosmetics and skincare product making containing the natural health vegetables oil of linoleic acid plus linolenic acid provided by the invention, can obviously increase the gloss of skin, moist, delicate skin, elasticity, improves or elimination wrinkle of skin, moisturizing, help skin to absorb nutritive ingredient, delaying skin aging, and there is the newborn baby's of making skin and red swelling of the skin, rotten to the corn disappearance.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. contain the natural health vegetables oil of linoleic acid plus linolenic acid, it is characterized in that, comprise any four kinds of above natural health vegetables oil of making as raw material of usining in Prinsepia utilis seed, perilla seed, elscholtiza, wrinkled giant hyssop Flos Carthami seed, wherein, in described natural health vegetables oil, linolic acid and linolenic mass ratio are 4-5:1.
2. the natural health vegetables oil containing linoleic acid plus linolenic acid according to claim 1, is characterized in that, the weight percent that described linolic acid accounts for described natural health content of vegetable oil is 40-50%.
3. the preparation method of the natural health vegetables oil containing linoleic acid plus linolenic acid described in claim 1 or 2, is characterized in that, comprises the following steps:
A, under hydraulic pressure normal temperature, by described raw material, at pressure, be to squeeze after certain hour under 20-60MPa, pressure release to pressure makes zero, and obtains squeezing crude oil;
B, the raw material squeezing is carried out to supercritical CO
2extraction is extracted crude oil;
C, described squeezing crude oil and described extraction crude oil are mixed, first through thin film distillation dehydration, degassed and deodorization, activated decoloration then, last freezing dewaxing, obtains described natural health vegetables oil.
4. the preparation method of the natural health vegetables oil containing linoleic acid plus linolenic acid according to claim 3, is characterized in that, in described step C, described squeezing crude oil and described extraction crude oil are standing more than 30 minutes at 10 ℃-50 ℃ after mixing.
5. the application of the natural health vegetables oil containing linoleic acid plus linolenic acid described in claim 1-2 any one in preparing healthcare products.
6. application according to claim 5, is characterized in that, by weight percentage, the addition of described natural health vegetables oil in healthcare products is 1-100%.
7. application according to claim 6, is characterized in that, by weight percentage, described healthcare products are pure described natural health vegetables oil
Or
Consisting of of described healthcare products:
Described natural health vegetables oil 2-95%
Vitamin-E 1-5%
Vitamin A 2-5%
Vitamins B 2-4%
Surplus is healthcare products edible adjuvant;
Preferably, described healthcare products edible adjuvant comprises one or more in commercially available edible flour or starch, Pollen Pini, pectin, lamb's-quarters flour and honey.
8. the application of the natural health vegetables oil containing linoleic acid plus linolenic acid described in claim 1-2 any one in preparing cosmetics and skincare product.
9. application according to claim 8, is characterized in that, by weight percentage, the addition of described natural health vegetables oil in cosmetics and skincare product is 10-90%.
10. application according to claim 9, is characterized in that, described cosmetics and skincare product comprises following composition: by weight percentage,
Described natural health vegetables oil 10-90%
Asian puccoon 1-10%
Vitamin-E 1-5%
Surplus is cosmetics and skincare product auxiliary material;
Preferably, described cosmetics and skincare product auxiliary material comprises any one or more in aloe water extract, aloe alcohol extract, aqueous extract from Eucommia ulmoides, ulmoprenol extract, only nail aqueous extract, only nail alcohol extract, Paris polyphylla aqueous extract, rhizoma paridis, Moisture factor and the whitening factor.
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Cited By (8)
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CN104232314A (en) * | 2014-10-16 | 2014-12-24 | 云南省农业科学院高山经济植物研究所 | Preparation method and health product of platycodon grandiflorum seed essential oil |
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CN115261129A (en) * | 2022-09-26 | 2022-11-01 | 云南省农业科学院园艺作物研究所 | Preparation method of high-quality prinsepia utilis royle oil suitable for cosmetic raw materials |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1304757A (en) * | 2000-12-07 | 2001-07-25 | 阮生 | Additive of medicine, food and cosmetics for supplementing oleic acid, linoleic acid and palmic acid |
CN1363649A (en) * | 2001-01-04 | 2002-08-14 | 和承尧 | Process for preparing nutritive oil rich in alpha-linolenic acid from nut of Elshotzia |
CN1566297A (en) * | 2003-06-27 | 2005-01-19 | 李俊霖 | Perilla oil and its preparation process and use |
CN1739368A (en) * | 2005-07-27 | 2006-03-01 | 山东新良油脂有限公司 | Vitamin-rich nutritive vegetable oil and its prepn process |
CN101502322A (en) * | 2009-03-06 | 2009-08-12 | 山东新良油脂有限公司 | Vitamin-rich plant nutrient blend oil and method for producing the same |
WO2009126798A1 (en) * | 2008-04-10 | 2009-10-15 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Seed extract rich in essentially fatty acids derived from salvia hispanica l. seed: composition of matter, manufacturing process and use |
CN101658210A (en) * | 2009-09-08 | 2010-03-03 | 李晓艳 | Perilla sesame oil and preparation method as well as application thereof |
CN102628002A (en) * | 2012-03-31 | 2012-08-08 | 华健 | Preparation process for prinsepia utilis royle grease |
CN103652857A (en) * | 2013-11-01 | 2014-03-26 | 安军 | Healthcare product for regulating blood fat and delaying senescence and preparation method thereof |
-
2014
- 2014-06-06 CN CN201410249601.6A patent/CN104004583B/en active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1304757A (en) * | 2000-12-07 | 2001-07-25 | 阮生 | Additive of medicine, food and cosmetics for supplementing oleic acid, linoleic acid and palmic acid |
CN1363649A (en) * | 2001-01-04 | 2002-08-14 | 和承尧 | Process for preparing nutritive oil rich in alpha-linolenic acid from nut of Elshotzia |
CN1566297A (en) * | 2003-06-27 | 2005-01-19 | 李俊霖 | Perilla oil and its preparation process and use |
CN1739368A (en) * | 2005-07-27 | 2006-03-01 | 山东新良油脂有限公司 | Vitamin-rich nutritive vegetable oil and its prepn process |
WO2009126798A1 (en) * | 2008-04-10 | 2009-10-15 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Seed extract rich in essentially fatty acids derived from salvia hispanica l. seed: composition of matter, manufacturing process and use |
CN101502322A (en) * | 2009-03-06 | 2009-08-12 | 山东新良油脂有限公司 | Vitamin-rich plant nutrient blend oil and method for producing the same |
CN101658210A (en) * | 2009-09-08 | 2010-03-03 | 李晓艳 | Perilla sesame oil and preparation method as well as application thereof |
CN102628002A (en) * | 2012-03-31 | 2012-08-08 | 华健 | Preparation process for prinsepia utilis royle grease |
CN103652857A (en) * | 2013-11-01 | 2014-03-26 | 安军 | Healthcare product for regulating blood fat and delaying senescence and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
程健等: "《天然产物超临界CO2萃取》", 30 June 2009, article "三、油脂的精制工艺", pages: 222 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104232314A (en) * | 2014-10-16 | 2014-12-24 | 云南省农业科学院高山经济植物研究所 | Preparation method and health product of platycodon grandiflorum seed essential oil |
CN104757142A (en) * | 2015-04-15 | 2015-07-08 | 刀玉丹 | Mixture of sacha inchi oil and honey |
CN105994691A (en) * | 2016-05-20 | 2016-10-12 | 洛阳泽达慧康医药科技有限公司 | Method for manufacturing blend oil with peony seed oil and acer truncatum oil |
CN106135466A (en) * | 2016-06-29 | 2016-11-23 | 贵州省油菜研究所 | A kind of perilla oil high efficiency extraction technique |
CN109943611A (en) * | 2019-02-25 | 2019-06-28 | 周国尧 | A kind of preparation method and applications of three seeds peptide and threeway oil |
CN109943611B (en) * | 2019-02-25 | 2021-03-30 | 周国尧 | Preparation method and application of three-seed peptide and three-way oil |
CN114727927A (en) * | 2019-11-11 | 2022-07-08 | 大峰Ls株式会社 | Moisturizing or anti-atopic compositions comprising fatty acids or fatty acid derivatives |
CN110870885A (en) * | 2020-01-19 | 2020-03-10 | 江西中医药大学 | A medicinal liquid with cleaning, sterilizing and moisturizing effects, and its application |
CN110870885B (en) * | 2020-01-19 | 2020-05-26 | 江西中医药大学 | A medicinal liquid with cleaning, sterilizing and moisturizing effects, and its application |
CN115261129A (en) * | 2022-09-26 | 2022-11-01 | 云南省农业科学院园艺作物研究所 | Preparation method of high-quality prinsepia utilis royle oil suitable for cosmetic raw materials |
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