CN103990228B - A kind of can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic - Google Patents
A kind of can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic Download PDFInfo
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Abstract
Can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, belong to oncotherapy medical apparatus and instruments.It comprises radio-frequency electrode, Double RF source, amplifirer, switch board, power supply, computer and therapeutic bed, radio-frequency electrode connects two amplifirers respectively by change-over switch, two amplifirers connect Double RF source respectively by two adapters, Double RF source connection control cabinet, switch board respectively with power supply, computer and therapeutic bed are connected, its technical essential is: the number of electrodes of radio-frequency electrode circumferential array is the odd number between 5-37, the focusing therapy of non-central tumor is convenient in design like this, by means of the effect of the electromagnetic field put on radio-frequency electrode array, realize organizing selective Fast Heating to tumor target, improve the tumor efficiency of heating surface, effectively can destroy the tumors of nutrients blood bed in patient body, the problem that the large area " wave field " can avoiding comprising tumor tissues is irradiated and caused normal structure impaired.
Description
Technical field:
The invention belongs to medical oncology apparatus, be specifically related to a kind of can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic.
Background technology:
Operative treatment tumor is acknowledged as one of optimal treatment method, secondly has x-ray radiotherapy machine, gamma-radiation cutter, laser scalpel etc. for suppressing with the therapeutic device of direct killing tumor cell.But other Therapeutic Method just must be taked for the patient some late periods and physical qualification difference being not suitable for carrying out operative treatment, as methods such as radiotherapy, chemotherapy, thermotherapy, freezing, ethanol thromboembolisms, wherein thermotherapy is another the important tumor therapeuticing method after radiotherapy, chemotherapy, is a kind of to the green Therapeutic Method of human body without any infringement.According to the characteristic of tumor formation mechenism and tumor cell, when tumor cell is subject to higher than will be automatically dead during body temperature certain value, people have invented the various instrument heating to treat tumor for this reason, the medical market thermal therapeutic apparatus of popularization and application kinds of tumors, as microwave principle, radio frequency principle, the thermal therapeutic apparatus etc. of ultrasonic wave principle, these thermal therapeutic apparatus utilize human body at microwave, capacitance field, under getting over the energy of sound wave, ionic agitation is produced and heat-dissipating in human body, and make the unique tissue structure of in-vivo tumour produce hot-spot, and then cause tumor tissues because of the overheated and result of necrosis, thus reach the object for the treatment of tumor.
Medical research shows, not only heats is good for the thermal therapeutic apparatus of employing radiothermics, and penetration power is strong, is a kind of ideal tumor-treatment instrument.Radio-frequency (RF) heat therapy equipment is a kind of intelligent tumor thermotherapy instrument radiofrequency signal being converted into heat energy, mainly pass through the certain unipolar radio-frequency signal generator of frequency, produce, the radiofrequency signal of launching higher-wattage produces a high-frequency alternating magnetic field, tissue around electrode will change by electromagnetic field effects, the ion of tissue (comprising tumor tissues) and polar molecule twist at elect magnetic field generation molecule, friction, produce heat, tissue temperature is raised, to in tumor heating process, normal structure blood flow enriches, smooth and easy, the heat absorbed can be carried away to whole body through blood circulation, without heat storage benefit, and tumor tissues thrombosis, heat cannot be taken away smoothly, produce heat retention, make the projecting normal structure 3-7 DEG C of its temperature, therefore, radio-frequency (RF) thermotherapeutic is the destruction utilizing the blood circulation difference of normal structure and tumor tissues to strengthen cancerous cell.
But radio-frequency therapeutic equipment still comes with some shortcomings, as caused overheated pain because of cooling difficulty, its therapeutic process still difficulty reaches tumor tissues and kills and wounds effect, and therapeutic effect has much room for improvement.And fix due to thermal therapeutic apparatus electrode mode of operation, the large area " wave field " comprising tumor tissues is adopted to irradiate, normal structure can be caused impaired, again because of energy out-focus, cause therapeutic efficiency low, be difficult to the tumors of nutrients blood bed destroyed completely in body, thoroughly kill tumor tissues, its curative effect is also difficult to the requirement meeting current cancer medical field.
Summary of the invention:
The object of this invention is to provide a kind of efficiently can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, the number of electrodes of its radio-frequency electrode circumferential array is the odd number between 5-37, be convenient to the focusing therapy of non-central tumor, effectively can destroy the tumors of nutrients blood bed in patient body, thoroughly kill tumor tissues, its curative effect is remarkable, the large area " wave field " comprising tumor tissues can be avoided to irradiate and the problem that causes normal structure impaired.
The object of the invention is to be achieved through the following technical solutions:
This can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, comprise radio-frequency electrode, Double RF source, amplifirer, switch board, power supply, computer and therapeutic bed, radio-frequency electrode connects two amplifirers respectively by change-over switch, two amplifirers connect Double RF source respectively by two adapters, Double RF source connection control cabinet, switch board is connected with power supply, computer and therapeutic bed respectively, described radio-frequency electrode is made up of the electrode of circumferential array, and the number of electrodes often on circle is the odd number between 5-37.
During work, selected electrode pair is determined according to the position of tumor, so-called electrode pair is that line is carried out on summit corresponding for face relative for the electrode of the diverse location of two in radio-frequency electrode, a cylinder must be formed between its line and two electrodes, and this cylinder region must can cover the tumor being in non-central location, two electrodes like this could form electrode pair, thus realize carrying out focusing therapy to the tumor being in non-central location.Often organize electrode pair can work successively in order or multi-group electrode to work in combination.In addition, thermal therapeutic apparatus of the present invention has bispectrum emission function, according to the kind of tumor and feature, can select different spectrum operation patterns, also can select staggered form mode of operation or combination type mode of operation.
The invention has the beneficial effects as follows: its radio-frequency electrode is arranged into superficial tumor specific region in the mode of circumferential array, the electrode of its circumferential array adds up to the odd number between 5-37, compared with prior art, there is more eccentric electrode pair, be convenient to the focusing therapy carrying out non-central tumor, wherein radio-frequency electrode can be the electrode of two circles coaxial circumferential array above, when radio-frequency electrode circumferential array is multi-turn electrode, according to position or the situation of tumor, wherein one group of electrode can be allowed to carry out work, the electrode of its cocycle quits work, or the work of multi-turn combination of electrodes, when multi-turn combination of electrodes works, electrode not on same circle can be made into electrode pair, three-dimensional focusing can be realized like this, effect can be better.The present invention be applicable to various just, in, the treatment of late tumor, by means of the effect of the electromagnetic field put on radio-frequency electrode array, realize the selective Fast Heating of in-vivo tumour destination organization, improve the tumor efficiency of heating surface, effectively can destroy the tumors of nutrients blood bed in patient body, thoroughly kill tumor tissues, its curative effect is remarkable, the large area " wave field " comprising tumor tissues can be avoided to irradiate and the problem that causes normal structure impaired.Its radio frequency electromagnetic field focus method is the electrode pair that select progressively electromagnetic field covers tumor, according to kind and the feature of tumor, selected electrode pair can sequential working or multi-group electrode to work in combination, along with the increase of radio-frequency electrode matrix number, the heat effect taking sequential working pattern effectively can reduce radio frequency electromagnetic field to produce human epidermal, reduces the hot causalgia of patient bitter.In addition the present invention has bispectrum emission function, according to the kind of tumor and feature, can select different spectrum operation patterns, also can select staggered form mode of operation or combination type mode of operation.
Accompanying drawing illustrates:
Fig. 1 is theory diagram of the present invention.
Fig. 2 is electrode focusing principle schematic diagram in embodiments of the invention one.
Fig. 3 is electrode focusing principle schematic diagram in embodiments of the invention two.
Fig. 4 is that in embodiments of the invention three, radio-frequency electrode circumferential array is the schematic diagram of the electrode of two circles.
Fig. 5 is half electrode focusing principle schematic diagram in embodiments of the invention three.
Fig. 6 is second half electrode focusing principle schematic diagram in embodiments of the invention three.
Fig. 7 is that in embodiments of the invention four, radio-frequency electrode circumferential array is the schematic diagram of the electrode of three circles
Fig. 8 is the half electrode focusing principle schematic diagram that in embodiments of the invention four, first electrode collar and the 3rd electrode collar carry out electrode pair.
Fig. 9 is second half electrode focusing principle schematic diagram that in embodiments of the invention four, first electrode collar and the 3rd electrode collar carry out electrode pair.
Figure 10 is the electrode focusing principle schematic diagram in embodiments of the invention four on second electrode collar.
Detailed description of the invention
Embodiment one
With reference to Fig. 1, of the present invention can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, comprise radio-frequency electrode, Double RF source, amplifirer, switch board, power supply, computer and therapeutic bed, radio-frequency electrode connects two amplifirers respectively by change-over switch, two amplifirers connect 100KHz low radio frequency source and 13.5MHz firing frequency source respectively respectively by two adapters, 100KHz low radio frequency source and 13.56MHz firing frequency source connection control cabinet respectively, switch board respectively with power supply, computer and therapeutic bed are connected, computer also connects power supply, two amplifirers connect two data processors respectively, two data processors connect two controllers respectively, described radio-frequency electrode is made up of the electrode of circumferential array, with reference to Fig. 2, the present embodiment is the electrode of a circle with radio-frequency electrode circumferential array, number of electrodes is 17 is example, suppose knub position human body lie low cross section fourth quadrant a bit on, 1 is have selected in Fig. 2
1-1
9, 1
2-1
10, 1
3-1
10, 1
4-1
11, 1
5-1
12, 1
6-1
13, 1
7-1
14, 1
8-1
16totally 8 groups of electrode pairs, as can be seen from Figure 2, number of electrodes is odd number, suitable electrode pair is selected according to tumor position in a coordinate system, the cylinder region that selected each electrode pair is formed is eccentric region, this eccentric region can cover the position at tumor place in fourth quadrant, is convenient to carry out focusing therapy to non-central tumor.During work, these 8 groups of electrode pairs can work in order successively, or multi-group electrode is to work in combination.
The electrode of the radio-frequency electrode circumferential array in the present embodiment also can be more than two circles, the electrode of a wherein circle is operationally only selected to carry out work, the electrode of its cocycle quits work, choose the electrode pair selected by the electrode on circle with in Fig. 28 groups of electrode pairs selecting identical.
Embodiment two
With reference to Fig. 3, with embodiment one unlike, the present embodiment for radio-frequency electrode circumferential array be the electrode of a circle, number of electrodes is 15, suppose knub position human body lie low cross section first quartile any on, have selected 1 in Fig. 3
1-1
8; 1
2-1
9; 1
3-1
10; 1
4-1
12; 1
5-1
13; 1
6-1
14; 1
7-1
15totally 7 groups of electrode pairs, as can be seen from Figure 3, number of electrodes is odd number, suitable electrode pair is selected according to tumor position in a coordinate system, the cylinder region that selected each electrode pair is formed is eccentric region, this eccentric region can cover the position at tumor place in first quartile, is convenient to carry out focusing therapy to non-central tumor.During work, these 7 groups of electrode pairs can work in order successively, or multi-group electrode is to work in combination.
The electrode of the radio-frequency electrode circumferential array in the present embodiment also can be more than two circles, the electrode of a wherein circle is operationally only selected to carry out work, the electrode of its cocycle quits work, choose the electrode pair selected by the electrode on circle with in Fig. 37 groups of electrode pairs selecting identical.
Embodiment three
With reference to Fig. 4, Fig. 5 and Fig. 6, with embodiment one unlike, the present embodiment is that number of electrodes on the electrode of two circles, each circle is 17 for radio-frequency electrode circumferential array, during work, tumor is between first lap electrode 1 and the second circle electrode 2, and according to tumor position in a coordinate system, the electrode chosen on first lap electrode 1 and the second circle electrode 2 forms electrode pair, suppose knub position human body lie low cross section first quartile a bit on, have selected 1 in Fig. 5 and Fig. 6
1-2
9; 1
2-2
10; 1
3-2
10; 1
4-2
11; 1
5-2
12; 1
6-2
13; 1
7-2
14; 1
8-2
16; 2
1-1
9; 2
2-1
10; 2
3-1
10; 2
4-1
11; 2
5-1
12; 2
6-1
13; 2
7-1
14; 2
8-1
16totally 16 groups of electrode pairs, selected electrode pair selects according to tumor position in a coordinate system, selected electrode pair is the electrode not on same circle, three-dimensional focusing can be realized like this, the cylinder region that each electrode pair is formed is eccentric region, this eccentric region can cover the position at tumor place in fourth quadrant, is convenient to carry out focusing therapy to non-central tumor.During work, these 16 groups of electrode pairs can work in order successively, or multi-group electrode is to work in combination.
Also the first electrode collar 1 can be enabled separately or the second circle electrode 2 carries out work, as the working method of embodiment one or embodiment two in the present embodiment.
Embodiment four
With reference to Fig. 7, Fig. 8, Fig. 9 and Figure 10, with embodiment one unlike, the present embodiment is that number of electrodes on the electrode of three circles, each circle is 15 for radio-frequency electrode circumferential array, during work, tumor is positioned at the second circle electrode 2, according to tumor position in a coordinate system, the electrode chosen on first lap electrode 1 and the 3rd circle electrode 3 forms electrode pair, simultaneously, electrode self on second circle electrode 2 is also carrying out electrode pair pairing, suppose knub position human body lie low cross section first quartile a bit on, have selected 1 in Fig. 8, Fig. 9 and Figure 10
1-3
8; 1
2-3
9; 1
3-3
10; 1
4-3
12; 1
5-3
13; 1
6-3
14; 1
7-3
15; 3
1-1
8; 3
2-1
9; 3
3-1
10; 3
4-1
12; 3
5-1
13; 3-1
14; 3
7-1
15; 2
1-2
8; 2
2-2
9; 2
3-2
10; 2
4-2
12; 2
5-2
13; 2-2
14; 2
7-2
15totally 21 groups of electrode pairs, selected electrode pair selects according to tumor position in a coordinate system, the first electrode collar 1 chosen and the 3rd circle electrode collar 3 top electrode are to being the electrode not on same circle, three-dimensional focusing can be realized like this, electrode pair on the second electrode collar 2 chosen continues to carry out focusing therapy to tumor locus, the cylinder region that each electrode pair is formed is eccentric region, this eccentric region can cover the position at tumor place in first quartile, is convenient to carry out focusing therapy to non-central tumor.These are mixed right electrode and can take turns to operate in order, also can work, or multi-group electrode are to work in combination simultaneously.
Also the first electrode collar 1 can be enabled separately in the present embodiment, or the second circle electrode 2, or the 3rd circle electrode carries out work, as the working method of embodiment one or embodiment two; Or choosing arbitrarily two circle electrodes carries out work, as the working method of embodiment three.
Number of electrodes on often enclosing in each embodiment above can also be other odd number between 5-37, and wherein 11,13,15,17,19,21 is preferred number, and its operation principle is identical with each embodiment.
In addition, the frequency in the Double RF source in the present invention can be adjusted to other suitable frequency values according to the practical situation of tumor, is not limited to the frequency values that embodiment provides.
Claims (8)
1. one kind can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it comprises radio-frequency electrode, Double RF source, amplifirer, switch board, power supply, computer and therapeutic bed, radio-frequency electrode connects two amplifirers respectively by change-over switch, two amplifirers connect Double RF source respectively by two adapters, Double RF source connection control cabinet, switch board is connected with power supply, computer and therapeutic bed respectively, it is characterized in that: described radio-frequency electrode is made up of the electrode of circumferential array, the number of electrodes often on circle is the odd number between 5-37.
2. as claimed in claim 1 can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it is characterized in that: the number of electrodes often on circle is the odd number of 11-21.
3. as claimed in claim 1 can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it is characterized in that: radio-frequency electrode is the electrode of two circles coaxial circumferential array above.
4. as claimed in claim 3 can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it is characterized in that: can match between the electrode not on same circle.
5. as claimed in claim 3 can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it is characterized in that: radio-frequency electrode is the electrodes of the coaxial circumferential array of 2 to 5 circle.
6. as claimed in claim 4 can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it is characterized in that: the electrode number often enclosed in radio-frequency electrode is identical.
7. as claimed in claim 6 can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it is characterized in that: often the electrode number enclosed on electrode is the odd number of 11-21.
8. as described in any one of claim 1-7 can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic, it is characterized in that: described Double RF source is respectively 100KHz and 13.56MHz.
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| EP4382160A3 (en) * | 2017-04-10 | 2024-08-14 | St. Jude Medical, Cardiology Division, Inc. | Electroporation system and method of energizing a catheter |
| CN107320105B (en) * | 2017-07-24 | 2023-11-28 | 北京大学 | A combined MRI and electromagnetic induction and radiofrequency therapy system |
| CN111939479A (en) * | 2020-08-20 | 2020-11-17 | 哈尔滨乔然科技有限公司 | Phased array thermotherapy machine and control method thereof |
| CN114304753B (en) * | 2022-02-24 | 2024-06-28 | 湖北中烟工业有限责任公司 | Multipole point radio frequency heating smoking set |
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| CN102210907A (en) * | 2010-04-06 | 2011-10-12 | Bsd医药公司 | Deep heating hyperthermia using phased arrays and patient positioning |
| CN103200894A (en) * | 2010-09-06 | 2013-07-10 | It`Is基金会 | Electromagnetic field applicator array with integral field sensors for implicit correction of mutual coupling and mismatch |
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| CN102210907A (en) * | 2010-04-06 | 2011-10-12 | Bsd医药公司 | Deep heating hyperthermia using phased arrays and patient positioning |
| CN103200894A (en) * | 2010-09-06 | 2013-07-10 | It`Is基金会 | Electromagnetic field applicator array with integral field sensors for implicit correction of mutual coupling and mismatch |
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