CN103977427A - Formula of sugar-coated aerogenic powder, and preparation method of sugar-coated aerogenic powder - Google Patents
Formula of sugar-coated aerogenic powder, and preparation method of sugar-coated aerogenic powder Download PDFInfo
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- CN103977427A CN103977427A CN201410192533.4A CN201410192533A CN103977427A CN 103977427 A CN103977427 A CN 103977427A CN 201410192533 A CN201410192533 A CN 201410192533A CN 103977427 A CN103977427 A CN 103977427A
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- China
- Prior art keywords
- sugar
- powder
- gas producing
- coat
- aerogenic
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- 239000000843 powder Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 244000248349 Citrus limon Species 0.000 claims abstract description 7
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 7
- 229920002472 Starch Polymers 0.000 claims abstract description 7
- 229930006000 Sucrose Natural products 0.000 claims abstract description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 7
- 235000010489 acacia gum Nutrition 0.000 claims abstract description 7
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims abstract description 7
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000012153 distilled water Substances 0.000 claims abstract description 7
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 7
- 239000001923 methylcellulose Substances 0.000 claims abstract description 7
- 239000008107 starch Substances 0.000 claims abstract description 7
- 235000019698 starch Nutrition 0.000 claims abstract description 7
- 239000005720 sucrose Substances 0.000 claims abstract description 7
- 235000020610 powder formula Nutrition 0.000 claims description 13
- 229920002494 Zein Polymers 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 239000008298 dragée Substances 0.000 claims description 6
- 239000007940 sugar coated tablet Substances 0.000 claims description 6
- 239000005019 zein Substances 0.000 claims description 6
- 229940093612 zein Drugs 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000005498 polishing Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000009495 sugar coating Methods 0.000 claims description 3
- 210000000214 mouth Anatomy 0.000 abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012174 chinese wax Substances 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 229910052788 barium Inorganic materials 0.000 description 6
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 6
- 238000007689 inspection Methods 0.000 description 5
- 235000012054 meals Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 210000003238 esophagus Anatomy 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention discloses a formula of sugar-coated aerogenic powder, and a preparation method of the sugar-coated aerogenic powder. The formula of the sugar-coated aerogenic powder comprises 100g of aerogenic powder, and sugar coat, and the sugar coat comprises 35g of starch, 15g of sucrose, 2g of lemon yellow, 1g of Arabic gum, 1g of methyl cellulose, 5g of talcum powder, 5g of a 10% zein-ethanol solution, 2g of glycerin, 15g of distilled water and 5g of Chinese wax powder. The sugar-coated aerogenic powder has the advantages of simple preparation, use convenience, no irritation to the oral cavity, extremely easy digestion in human bodies, and no influences on the examination result, and can be easily accepted by patients especially child patients.
Description
Technical field
The present invention relates to a kind of sugar-coat gas producing powder formula and preparation method thereof.
Background technology
At present, when hospital does digestive canel barium meal contrast examination inspection clinically, generally use gas producing powder to meet the inspection of gas barium double-contrast, patient need directly pour the gas producing powder of doses in mouth and use mixing in water for oral taking, and gas producing powder makes stomach organ expand to facilitate the inspection of instrument after entering in patient body.Because the gas generating agent that checks use is powdery, in the time entering patient oral cavity, oral mucosa is had to stronger stimulation, generally there is cough and choke phenomenon in patient, even dysphagia brings unnecessary trouble and psychic pain to the patient who seeks medical advice, especially cannot check some special patients that suffer from the illness of swallowing, meanwhile, due to the restriction of the water that is subject to taking after mixing it with water, part gas producing powder is trapped in oral cavity, throat and esophagus, cause stomach gas production deficiency, and then affected inspection effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of sugar-coat gas producing powder formula and preparation method thereof.This sugar-coat gas producing powder is filled a prescription to oral cavity nonirritant, in human body, very easily dissolves, and does not affect inspection effect, is easily accepted by patient especially child patient.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: described sugar-coat gas producing powder formula is made up of following raw material: gas producing powder and sugar-coat, the parts by weight of described gas producing powder are: gas producing powder 100g, described sugar-coat component and parts by weight proportioning are: the zein alcoholic solution of 35g starch, 15g sucrose, 2g lemon yellow, 1g arabic gum, 1g methylcellulose, 5g Pulvis Talci, 5g10%, 2g glycerol, 15g distilled water, 5g river wax powder.
Another technical problem to be solved by this invention is to provide a kind of sugar-coat gas producing powder formula and preparation method thereof.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: comprise the following steps:
1) proportioning is extracted 35g starch, 15g sucrose, 2g lemon yellow, 1g arabic gum, 1g methylcellulose and 5g Pulvis Talci grind into powder by weight, for subsequent use;
2) zein alcoholic solution, the 2g glycerol of the 5g10% of proportioning extraction are by weight poured mix homogeneously in 15g distilled water into;
3) by step 1) in powder and step 2) in mixed liquor be together positioned in blender and stir, be stirred to after being paste type object and stop;
4) by step 3) in paste type object be divided into 200 parts, together put into special sugar coating machine with 100g gas producing powder, be rolled into 200 sugar coated tablets;
5) by step 4) in sugar coated tablet with after hot blast drying, cooling, be spilled into the river wax powder that 5g prepared and carry out polishing, get product.
The beneficial effect of a kind of sugar-coat gas producing powder of the present invention formula and preparation method thereof is: the sense of patient's no pain, can disposable clothes under, easy to operate, producing powder amount can all play a role, and all can not produce trapping phenomena in oral cavity, throat and esophagus.
Detailed description of the invention
For further understanding feature of the present invention, technological means and the specific purposes that reach, function, with detailed description of the invention, the present invention is described in further detail below.
Embodiment
A kind of sugar-coat gas producing powder formula of the present invention, described sugar-coat gas producing powder formula is made up of following raw material: gas producing powder and sugar-coat, the parts by weight of described gas producing powder are: gas producing powder 100g, and described sugar-coat component and parts by weight proportioning are: the zein alcoholic solution of 35g starch, 15g sucrose, 2g lemon yellow, 1g arabic gum, 1g methylcellulose, 5g Pulvis Talci, 5g10%, 2g glycerol, 15g distilled water, 5g river wax powder;
The preparation method process of described sugar-coat gas producing powder formula is as follows:
1) proportioning is extracted 35g starch, 15g sucrose, 2g lemon yellow, 1g arabic gum, 1g methylcellulose and 5g Pulvis Talci grind into powder by weight, for subsequent use;
2) zein alcoholic solution, the 2g glycerol of the 5g10% of proportioning extraction are by weight poured mix homogeneously in 15g distilled water into;
3) by step 1) in powder and step 2) in mixed liquor be together positioned in blender and stir, be stirred to after being paste type object and stop;
4) by step 3) in paste type object be divided into 200 parts, together put into special sugar coating machine with 100g gas producing powder, be rolled into 200 sugar coated tablets;
5) by step 4) in sugar coated tablet with after hot blast drying, cooling, be spilled into the river wax powder that 5g prepared and carry out polishing, get product.
Experimental example:
Experimental subject: 8 have just been carried out the patient of canel barium meal contrast examination.
Experimental technique and time: 8 patients first take sugar-coat gas producing powder formula of the present invention and carry out canel barium meal contrast examination, record result 1, then take general gas producing powder and carry out canel barium meal contrast examination, record result 2, and two times result is contrasted.Experimental result:
Remarks: have 5 people to have minimal disease not check out with respect to result 1 result 2.
| ? | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 |
| Mouthfeel (result 1) | Good | Better | Good | Good | Good | Good | Good | Better |
| Mouthfeel (result 2) | Poor | Poor | Poor | Poor | Poor | Poor | Generally | Poor |
After this patient of experimental group has been carried out to health investigation, do not found any side effect.
Experimental result is known thus, and sugar-coat gas producing powder formula of the present invention, to the non-stimulated sense in oral cavity, is easily accepted by patient especially child patient, and be conducive to barium meal examination effect.
Below the present invention is described in detail, the above, be only the present invention's preferred embodiment, when not limiting the scope of the present invention, allly does impartial variation and modification according to the application's scope, all should still belong in covering scope of the present invention.
Claims (2)
1. a sugar-coat gas producing powder formula, it is characterized in that: described sugar-coat gas producing powder formula is made up of following raw material: gas producing powder and sugar-coat, the parts by weight of described gas producing powder are: gas producing powder 100g, described sugar-coat component and parts by weight proportioning are: the zein alcoholic solution of 35g starch, 15g sucrose, 2g lemon yellow, 1g arabic gum, 1g methylcellulose, 5g Pulvis Talci, 5g 10%, 2g glycerol, 15g distilled water, 5g river wax powder.
2. a preparation method for sugar-coat gas producing powder formula as claimed in claim 1, is characterized in that: comprise the following steps:
1) proportioning is extracted 35g starch, 15g sucrose, 2g lemon yellow, 1g arabic gum, 1g methylcellulose and 5g Pulvis Talci grind into powder by weight, for subsequent use;
2) zein alcoholic solution, the 2g glycerol of the 5g 10% of proportioning extraction are by weight poured mix homogeneously in 15g distilled water into;
3) by step 1) in powder and step 2) in mixed liquor be together positioned in blender and stir, be stirred to after being paste type object and stop;
4) by step 3) in paste type object be divided into 200 parts, together put into special sugar coating machine with 100g gas producing powder, be rolled into 200 sugar coated tablets;
5) by step 4) in sugar coated tablet with after hot blast drying, cooling, be spilled into the river wax powder that 5g prepared and carry out polishing, get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410192533.4A CN103977427A (en) | 2014-05-08 | 2014-05-08 | Formula of sugar-coated aerogenic powder, and preparation method of sugar-coated aerogenic powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410192533.4A CN103977427A (en) | 2014-05-08 | 2014-05-08 | Formula of sugar-coated aerogenic powder, and preparation method of sugar-coated aerogenic powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103977427A true CN103977427A (en) | 2014-08-13 |
Family
ID=51269746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410192533.4A Pending CN103977427A (en) | 2014-05-08 | 2014-05-08 | Formula of sugar-coated aerogenic powder, and preparation method of sugar-coated aerogenic powder |
Country Status (1)
| Country | Link |
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| CN (1) | CN103977427A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940961A (en) * | 2015-07-07 | 2015-09-30 | 上海交通大学医学院附属瑞金医院 | A kind of intragastric pH detection micropill and its application |
| CN108187073A (en) * | 2018-01-10 | 2018-06-22 | 东南大学 | A kind of pharmaceutical composition, preparation method and applications for carrying nano particle |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6254888B1 (en) * | 2000-01-28 | 2001-07-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for coating pharmaceutical dosage forms |
| CN2652385Y (en) * | 2003-09-04 | 2004-11-03 | 李富永 | Package capsule for barium meal fluoroscopy gas producing powder |
| CN2744341Y (en) * | 2004-10-25 | 2005-12-07 | 刘恒顺 | Air generation capsule for air-barium double contrast radiography of small intestine |
| CN101084881A (en) * | 2007-06-23 | 2007-12-12 | 淮北市辉克药业有限公司 | Targeted quick-releasing effervescence preparation and preparation method thereof |
| CN101193625A (en) * | 2005-06-10 | 2008-06-04 | 武田药品工业株式会社 | Sugar-coated preparation |
| CN101267809A (en) * | 2004-06-07 | 2008-09-17 | 惠氏公司 | Sugar coatings and methods therefor |
-
2014
- 2014-05-08 CN CN201410192533.4A patent/CN103977427A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6254888B1 (en) * | 2000-01-28 | 2001-07-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for coating pharmaceutical dosage forms |
| CN2652385Y (en) * | 2003-09-04 | 2004-11-03 | 李富永 | Package capsule for barium meal fluoroscopy gas producing powder |
| CN101267809A (en) * | 2004-06-07 | 2008-09-17 | 惠氏公司 | Sugar coatings and methods therefor |
| CN2744341Y (en) * | 2004-10-25 | 2005-12-07 | 刘恒顺 | Air generation capsule for air-barium double contrast radiography of small intestine |
| CN101193625A (en) * | 2005-06-10 | 2008-06-04 | 武田药品工业株式会社 | Sugar-coated preparation |
| CN101084881A (en) * | 2007-06-23 | 2007-12-12 | 淮北市辉克药业有限公司 | Targeted quick-releasing effervescence preparation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 侯惠民: "《药用辅料应用技术》", 30 July 2002, 中国医药科技出版社, article "着色剂", pages: 59 * |
| 梁文权: "《药剂学》", 31 August 2006, 科学技术文献出版社, article "片剂的包衣", pages: 141-142 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940961A (en) * | 2015-07-07 | 2015-09-30 | 上海交通大学医学院附属瑞金医院 | A kind of intragastric pH detection micropill and its application |
| CN104940961B (en) * | 2015-07-07 | 2017-10-17 | 上海交通大学医学院附属瑞金医院 | Intragastric pH detection pellet and application thereof |
| CN108187073A (en) * | 2018-01-10 | 2018-06-22 | 东南大学 | A kind of pharmaceutical composition, preparation method and applications for carrying nano particle |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20140813 |