CN103977158B - Repairing solution for treating soft tissue trauma of animals and preparation method thereof - Google Patents
Repairing solution for treating soft tissue trauma of animals and preparation method thereof Download PDFInfo
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The invention relates to the field of medical treatment, and particularly relates to a repairing solution for treating soft tissue trauma of animals and a preparation method thereof. The repairing solution is prepared from the following raw material components in parts by weight: 5-15 parts of camphor oil, 45-60 parts of yolk oil, 5-15 parts of tetrastigma hemsleyanum diels et gilg and 10-20 parts of eugenol. The repairing solution can be used for repelling parasites in animal hairs, is suitable for treating symptoms of lipsotrichia, pruritus, erythema, incrustation, pustule and other skin diseases of animals, has excellent antibacterial and anti-inflammatory effects, can be used for effectively solving the infection problems of virus, fungi, bacteria and the like on animal local skin, and has the effect of promoting an injured part to actively heal, thus shortening the time of wound healing in the process of treating the wound. Furthermore, the components of the repairing solution are safe and do not have toxic or side effect, so that no adverse influence is generated when the animal licks the repairing solution after the repairing solution is applied to the wound surface of an animal.
Description
Technical field
The present invention relates to medical field, the reparation liquid in particular to treatment animal soft tissue wound and its preparation side
Method.
Background technology
When various different force act on animal body, the destruction of animal organism soft tissue structure is caused to be referred to as wound,
This kind of wound is often accompanied by different degrees of locally and systemically reaction.Traumatogenic common cause has sharp property object (as steel wire, tree
Wooden fork) piercing, the cutting of sheet glass, iron plate etc., club hit, bait mutually wound etc..In addition, the flesh that animal self-disease is formed
Body ulcer falls within wound category.
In the related, the medicine with regard to treating animal cuticle wound has multiple in the market, and these products are mostly
It is based on anti-inflammation, such as, the tincture of iodine, alcohol, bromogeramine, physiological saline, antibiotic liquid, sulfa powder, wide spectrum resist common medicine
The medicines such as raw element, adrenocortical hormone, aspirin and phenylbutazone.The mechanism of its treatment wounds in animals is for wound face
One antibacterial local environment preventing from infecting is provided, so that the surface of a wound is healed spontaneously, it does not have makes wound site active reparation heal
The effect closed.Therefore, make the time needed for wound healing all long using these traditional medicines.
Content of the invention
It is an object of the invention to provide a kind of reparation liquid treating animal soft tissue wound, above-mentioned to solve the problems, such as.
Further object is that providing a kind of preparation side of the reparation liquid of above-mentioned treatment animal soft tissue wound
Method.
Provide the reparation liquid for the treatment of animal soft tissue wound in an embodiment of the present invention, in parts by weight, its
Material component includes：Camphorated oil 5-15 part, egg oil 45-60 part, tetratigma hemsleyanum 5-15 part, eugenol 10-20 part.
The reparation liquid of this treatment animal soft tissue wound that the present invention provides, by theory of traditional Chinese medical science compatibility, each plant of drawing materials
Extract and configure.Its mechanism is as follows：Camphor, pungent, hot, there are dehumidifying desinsection, warming and odynolysis, have one's ideas straightened out and ward off dirty effect.《This grass product
Converging essence will》Cloud " the main desinsection of camphor except mange, is treated sore due to scald and burn, opposed oxious gas ".《Surgery great achievement》Record " if with alumen, calomel mercurous chloride being altogether
Smalls, wet, dry mix, dry then oil dresses, and can control ulcer on the shank " (as perfume (or spice) dissipates in vain)；《Surgery raw collection entirely》Then cloud is " if be divided into realgar
End, the used time first washes affected part with schizonepeta decoct soup, then adjusts painting with sesame oil, can control scrofula and fester, and such as male brain dissipates ".Camphorated oil is by camphor tree
Dry and leaf extracts through steam distillation, has the function of whole camphors.The odor property of camphor, expelling parasite sterilizing (animal skin
Interior parasite is the key factor its wound being caused infect), the skin injury of house pet is had special treatment with
Prevention effect.Tetratigma hemsleyanum is the exclusive swag Wild Medicinal of China.Cool in nature, sweet, have no toxic side effect (China people
Between often outer be used for controlling venomous snake bite, skin cellulitis, traumatic injury), there is clearing heat and detoxicating antimicrobial and anti-inflammation efficacy.Egg oil contains
There are the Multiple components such as rich in protein, vitamin A, riboflavin, lecithin, oleic acid, linoleic acid, fat, zinc, iron, can promote
The growth of mucosal epithelium, increases the anti-infectious ability of body, the healing of acceleration of wound tissue.As《Compendium of Materia Medica》Cloud " chicken
Ovum is fried and is taken oil, and powder applies head sore ".Cloves is cool in nature, bitter and puckery flavor, nontoxic, enters lung, spleen, stomach, kidney four warp.《Quanzhou book on Chinese herbal medicine》Cloud " cloves
Clearing heat and detoxicating, promoting diuresis for stranguria；Control oedema, blood strangury, ulcer, furunculosis, nameless sores or boils ".Eugenol is the main active of cloves,
Its pharmacological action is extremely extensive, is mainly shown as and can reach antioxidation by scavenging activated oxygen, to malignant bacteria and fungi tool
There is inhibitory action, to fish, there is anesthetic effect, Drug Percutaneous Absorption can be promoted, by affecting PO/AH (preop- tic area-hypothalamus
Anterior) Thermosensitive Neurons reach refrigeration function, have mosquito effect etc. of dispelling, the application prospect in Animal husbandry production is very wide
Wealthy.
This reparation liquid provided in an embodiment of the present invention, the parasite in its energy animal repelling hair；It is suitable for treatment animal
Depilation, itch, erythema, incrustation, the dermatological conditions such as purulence born of the same parents；There are good antibacterial and anti-inflammation functions, can effectively treat dynamic
The infection problems such as thing local skin virus, fungi and bacterium；Compared with wound medicine common in the art, it not only has
The effect of sterilization, in addition, it is also equipped with the effect making wound site actively heal, can be effectively facilitated the life of surface of a wound cell tissue
Long, repair epidermis, mucosal tissue wound and ulcer；So, it shortens needed for wound healing during controlling treatment trauma
Time, have broad application prospects.
In addition, this reparation liquid that the present invention provides, the equal safe without toxic side effect of its component, so be applied to animal when it
The surface of a wound when, animal licks to lick and has no adverse effects.Overcome and lick, when animal licks, the surface of a wound scribbling anti-inflammation drugs common in the art
When, animal may be caused with the defect of various toxic and side effects.
Optionally, described tetratigma hemsleyanum is powder between 110-130 mesh for the particle diameter.
The embodiment of the present invention additionally provides a kind of preparation method of the reparation liquid according to above-mentioned treatment animal soft tissue wound,
Comprise the following steps：
Tetratigma hemsleyanum is crushed to powder；
The egg oil of set parts by weight is heated to after 60-80 DEG C, adds the powder of set parts by weight wherein
Tetratigma hemsleyanum, obtains solidliquid mixture；
Described solidliquid mixture is naturally cooled to room temperature, adds camphorated oil and the cloves of set parts by weight wherein
Phenol, stirs, and obtains repairing liquid.
Optionally, after the egg oil of set parts by weight is heated to 60-80 DEG C by described step, add set wherein
The powder tetratigma hemsleyanum of parts by weight, obtains in solidliquid mixture：
When adding the powder tetratigma hemsleyanum of set parts by weight, it is stirred, and be incubated 50-70 at 60-80 DEG C
Minute.
Optionally, after the described egg oil by set parts by weight is heated to 60-80 DEG C, add set weight wherein
The powder tetratigma hemsleyanum of number, obtains in the step of solidliquid mixture, and described heating is specially and carries out adding using electric food warmer
Heat.
Brief description
In order to be illustrated more clearly that the specific embodiment of the invention or technical scheme of the prior art, below will be to concrete
In embodiment or description of the prior art the accompanying drawing of required use be briefly described it should be apparent that, below describe in
Accompanying drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not paying creative work
Put, other accompanying drawings can also be obtained according to these accompanying drawings.
The preparation flow schematic diagram of the reparation liquid of the treatment animal soft tissue wound that Fig. 1 provides for the embodiment of the present invention four.
Specific embodiment
For making the object, technical solutions and advantages of the present invention clearer, technical scheme will be carried out below
Clear, complete description, based on the specific embodiment in the present invention, those of ordinary skill in the art are not making creativeness
On the premise of work, obtained all other embodiment, broadly falls into the scope that the present invention is protected.
The reparation liquid of this treatment animal soft tissue wound that the present invention provides, in parts by weight, its material component
Including：Camphorated oil 5-15 part, egg oil 45-60 part, tetratigma hemsleyanum 5-15 part, eugenol 10-20 part.And it is preferred that institute
Stating tetratigma hemsleyanum is powder between 110-130 mesh for the particle diameter.
Next, the present invention, herein in connection with above-mentioned content, provides to the composition of the reparation liquid for the treatment of animal soft tissue wound
Embodiment in detail below：
Embodiment one
The reparation liquid of the treatment animal soft tissue wound of the present embodiment, in parts by weight, its material component includes：Camphor tree
5 parts of cerebrol, 45 parts of egg oil, 5 parts of tetratigma hemsleyanum, 10 parts of eugenol；The powder that described tetratigma hemsleyanum is 120 mesh for particle diameter
Shape.
Embodiment two
The reparation liquid of the treatment animal soft tissue wound of the present embodiment, in parts by weight, its material component includes：Camphor tree
10 parts of cerebrol, 50 parts of egg oil, 10 parts of tetratigma hemsleyanum, 15 parts of eugenol；Described tetratigma hemsleyanum is the powder in 120 mesh for the particle diameter
Last shape.
Embodiment three
The reparation liquid of the treatment animal soft tissue wound of the present embodiment, in parts by weight, its material component includes：Camphor tree
15 parts of cerebrol, 60 parts of egg oil, 15 parts of tetratigma hemsleyanum, 20 parts of eugenol；The powder that described tetratigma hemsleyanum is 120 mesh for particle diameter
Last shape.
So that the reparation liquid of the treatment animal soft tissue wound of the above embodiment of the present invention is preferably applied, more
Use in Traditional Chinese health field added with effect, the present invention also provides example IV on the basis of above-described embodiment, implement
The preparation method that example four gives the reparation liquid of the treatment animal soft tissue wound of above-described embodiment, is now described in detail reconciliation
Release, refer to Fig. 1：
Example IV
Refer to Fig. 1, in the present embodiment, the preparation method of the reparation liquid for the treatment of animal soft tissue wound includes following step
Suddenly：
Step 101：Tetratigma hemsleyanum is crushed to powder；
In this step, tetratigma hemsleyanum number belongs to a kind of Vitaceae and climbs up by holding on to this, and constant is connected, therefore, make
During, pulverized after needing to be dried, obtain the raw material of powder, then it is mixed with other components.
Step 102：The egg oil of set parts by weight is heated to after 60-80 DEG C, adds set parts by weight wherein
Powder tetratigma hemsleyanum, obtain solidliquid mixture；
In a step 102, in order to reach more preferable drug effect, need to be heated egg oil so as to be reached 60-80 DEG C,
Then add the tetratigma hemsleyanum of powder more wherein, so, the active princlple of tetratigma hemsleyanum and egg oil can fill
Analyze and mix, its drug effect is more significantly.It is preferred that being heated using electric food warmer during heating, electric heating
The mode of heating is more slow and easy to operate, its can effectively prevent partly thermo-labile effective component due to the too fast and quilt of heating up
Destroy.
Additionally, it is preferred that, during adding tetratigma hemsleyanum powder, in order to reach the effect mixed thoroughly in addition it is also necessary to enter
Row stirring, even if adding side stirring, and continues to be incubated 50-70 minute at 60-80 DEG C during adding；So, two medicines
While thing mixes, also fully separate out beneficial to its contained drug effect component.
Step 103：Described solidliquid mixture is naturally cooled to room temperature, adds the camphorated oil of set parts by weight wherein
And eugenol, stir, obtain repairing liquid.
The preparation method of the reparation liquid of this treatment animal soft tissue wound provided in an embodiment of the present invention, its operation letter
Just it is not necessary to complicated huge equipment can achieve the preparation repairing liquid.
In addition, the reparation liquid that the present invention is provided using embodiment two, as test sample, has carried out corresponding experimental study, with
Phase further instruction its there is the repair function of wound healing, specifically refer to herein below：
Animal used as test：SD rat 30, male and female half and half, 200 grams about of body weight, purchased from medical college of University Of Nanchang animal used as test
Research center.30 rats are randomly divided into three groups, every group 10：Experimental group (A group), positive controls (B group), negative control group
(C group).
Experimental drug and reagent：Experimental group (A group)：The use of medicine is " the reparation liquid of the embodiment of the present invention two ".Positive right
According to group (B group)：The use of medicine is jingwanhong soft plaster ointment, is produced by Tianjin Da Rentang pharmaceutcal corporation, Ltd, lot number 211516；Negative right
According to group (C group)：Using common medical saline (0.9% sodium chloride).
Experimental technique：
1st, modeling：Lost hair or feathers to rat rabbit back with 8% vulcanized sodium, expose the skin of about 2cm × 2cm, after 2 days, use 10%
Chloral hydrate anesthesia, and with the tincture of iodine, alcohol disinfecting, left of spine or right side do 1 diameter be about 1cm about circular wound
Face, excision surface of a wound full thickness skin is organized to fascia superficialis.
2nd, it is administered：From operation, the A group animal surface of a wound drips the reparation liquid that 2-3 drips the embodiment of the present invention two, and 3 times a day
Or the surface of a wound do after drip again；The B group surface of a wound is uniformly coated with jingwanhong soft plaster cream, with flap coverage for degree, daily 2-3 time；The C group surface of a wound drips physiology
Salt solution, method and frequency are with A group animal used as test.The administration of all animals is carried out daily, until wound healing.
3rd, wound healing situation is observed：Visually observe the healing state of the surface of a wound, observation index is：The number of exudate amount,
The change of edge of wound skin contraction, incrustation and skin color.
4th, the mensure of Wound healing rate and healing time：After surgery the 3rd, 7,10,14d, using retouch meter weight method measurement
Area, that is, use transparent membrane flap coverage, marks along surface of a wound edge, draws required areal extent and cuts, with scale division value is
The assay balance of 0.1mg claims quality and replaces area, by Wound healing rate=(original surface of a wound area-do not heal the surface of a wound with quality
Area)/original surface of a wound area, calculate Wound healing rate.Standard with 95% Wound healing rate as healing time, records each
The healing time of the surface of a wound.
5th, data processing：One-way analysis of variance is carried out to experimental data using SPSS17.0 statistical software；When variance is neat
Row t checks, row correction t inspection during heterogeneity of variance.P<It is significant difference when 0.05, P<It is difference highly significant when 0.01.
Experimental result：
1st, the healing state of the rat skin surface of a wound：
It is observed visually each group animal 1d after surgery and 2d, the surface of a wound of all animals has been substantially all diffusate,
Wound does not start to heal.
There is the diffusate of 3 substantially to disappear in 10 animals of postoperative 3d, C group, and start to form a scab, remaining edge of wound skin is received
Contracting is inconspicuous, and 2 wounds start a little blush；The diffusate of 6 surface of a wound of B group disappears substantially, and edge of wound skin starts to shrink at,
And start to form a scab, wherein 5 wounds start a little blush；The diffusate of 9 is had substantially to disappear in 10 animals of A group, wound
Edge skin starts to shrink at, and starts to form a scab, and has 8 wounds to start a little blush.
Postoperative 7d, C group still has 4 surface of a wound to moisten, and has exudate, contraction of wounds is inconspicuous, has no on significantly newborn
Skin；B group 7 is dried, no infects with 10 rat surface of a wound of A group, and edge of wound skin contraction is obvious.
Postoperative 14d, C group wound repair is not good enough, still has 5 not heal；B group 2 does not heal；A group all healed.
2nd, Wound healing rate and wound healing time：
The mean value that the Wound healing rate of each group experimental animal is surveyed, the overall average of wound healing time are shown in Table 1.
Table 1. each group wound healing rate x ± s, % and healing time
Note：Compare in C group, * P<0.05, * * P<0.01.
Above-mentioned experimental result points out the reparation liquid of the present invention obvious with repairing effect to the treatment of rat skin wound, simultaneously
There is good anti-infectious function, no matter in terms of the wound healing rate or healing time from the point of view of, it is soft that its effect is better than jingwanhong soft plaster
Cream.Therefore, the reparation liquid of the present invention should have same treatment and repairing effect to other mammalian pets skin traumas；And it is right
In animal pets, typically discuss, when it has the surface of a wound, most animals all exist licks the phenomenon licked, and by some traumatic pains
When antiphlogistic is applied to its surface of a wound, animal licks after licking it may happen that toxic and side effect, there is potential safety hazard.And the embodiment of the present invention carries
For this reparation liquid, substitute traditional Western medicine with pure Chinese medicine material, for animal skin feature, effective restraining and sterilizing bacteria, the nutrition surface of a wound
Epithelial cell tissues, realize the effect of the clearing heat and detoxicating healing accelerating the surface of a wound by strengthening animal its body ability, and animal licks
After licking, there is not potential safety hazard in it.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, made any repair
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (5)
1. a kind of reparation liquid treating animal soft tissue wound is it is characterised in that in parts by weight, its raw material by：
Camphorated oil 5-15 part, egg oil 45-60 part, tetratigma hemsleyanum 5-15 part, eugenol 10-20 part composition.
2. the reparation liquid for the treatment of animal soft tissue wound according to claim 1 is it is characterised in that described tetratigma hemsleyanum
For powder between 110-130 mesh for the particle diameter.
3. a kind of according to claim 1 treatment animal soft tissue wound reparation liquid preparation method it is characterised in that
Comprise the following steps：
Tetratigma hemsleyanum is crushed to powder；
The egg oil of set parts by weight is heated to after 60-80 DEG C, adds powder three leaf of set parts by weight wherein
Rattan is climbed on precipice, obtains solidliquid mixture；
Described solidliquid mixture is naturally cooled to room temperature, adds camphorated oil and the eugenol of set parts by weight wherein, stir
Mix uniformly, obtain repairing liquid.
4. the preparation method of the reparation liquid for the treatment of animal soft tissue wound according to claim 3 is it is characterised in that in institute
State step and the egg oil of set parts by weight is heated to after 60-80 DEG C, add the powder three of set parts by weight wherein
Rattan is climbed on leaf precipice, obtains in solidliquid mixture：
When adding the powder tetratigma hemsleyanum of set parts by weight, it is stirred, and be incubated 50-70 minute at 60-80 DEG C.
5. the preparation method of the reparation liquid for the treatment of animal soft tissue wound according to claim 3 is it is characterised in that in institute
State and the egg oil of set parts by weight is heated to after 60-80 DEG C, add the powder three leaf precipice of set parts by weight wherein
Climb rattan, obtain in the step of solidliquid mixture, described heating is specially is heated using electric food warmer.
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| CN115120535A (en) * | 2022-07-21 | 2022-09-30 | 南京欣腾瑞生物科技有限公司 | Licking external cream for relieving pruritus of cat dermatophytes and preparation method thereof |
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| Title |
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| "蛋黄油治疗家畜外伤";王伟;《黑龙江畜牧兽医》;19860630;第29页左列倒数第2行-右列第1行 * |
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